locus-tag	class	description
SAM40697_RS00025	COG2815	serine threonine protein kinase
SAM40697_RS00025	COG0515	serine threonine protein kinase
SAM40697_RS00045	COG1793	dna ligase
SAM40697_RS00060	COG2072	flavoprotein involved in K transport
SAM40697_RS00065	COG0640	Transcriptional regulator
SAM40697_RS00100	COG0492	ferredoxin-NADP+ reductase activity
SAM40697_RS00105	COG0798	PFAM Bile acid sodium symporter
SAM40697_RS00115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM40697_RS00120	COG0492	ferredoxin-NADP+ reductase activity
SAM40697_RS00215	COG2814	Major facilitator Superfamily
SAM40697_RS00245	COG4946	Tricorn protease homolog
SAM40697_RS00245	COG1506	peptidase
SAM40697_RS00245	COG0823	Involved in the tonB-independent uptake of proteins
SAM40697_RS00285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM40697_RS00300	COG0702	epimerase
SAM40697_RS00360	COG1278	Cold shock
SAM40697_RS00375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM40697_RS00380	COG1335	isochorismatase
SAM40697_RS00385	COG1131	(ABC) transporter
SAM40697_RS00410	COG0142	geranyltranstransferase activity
SAM40697_RS00420	COG2770	Histidine kinase
SAM40697_RS00420	COG2208	phosphoserine phosphatase activity
SAM40697_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS00495	COG1278	Cold shock
SAM40697_RS00500	COG0513	Belongs to the DEAD box helicase family
SAM40697_RS00525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM40697_RS00570	COG0494	nUDIX hydrolase
SAM40697_RS00680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS00715	COG3629	intracellular signal transduction
SAM40697_RS00715	COG3903	Transcriptional regulator
SAM40697_RS00720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM40697_RS00740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS00760	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS00770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS00780	COG0154	amidase activity
SAM40697_RS00865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS00925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS00930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS00945	COG3629	intracellular signal transduction
SAM40697_RS00960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS00980	COG3226	Transcriptional regulator
SAM40697_RS01000	COG1733	regulation of RNA biosynthetic process
SAM40697_RS01065	COG1115	amino acid carrier protein
SAM40697_RS01070	COG2801	Transposase and inactivated derivatives
SAM40697_RS01075	COG2963	transposase activity
SAM40697_RS01130	COG0657	acetylesterase activity
SAM40697_RS01150	COG2814	Major facilitator Superfamily
SAM40697_RS01170	COG2815	serine threonine protein kinase
SAM40697_RS01170	COG0515	serine threonine protein kinase
SAM40697_RS01175	COG1595	DNA-templated transcription, initiation
SAM40697_RS01185	COG1131	(ABC) transporter
SAM40697_RS01235	COG2814	Major facilitator Superfamily
SAM40697_RS01240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS01245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM40697_RS01260	COG1621	beta-fructofuranosidase activity
SAM40697_RS01265	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS01270	COG1175	transmembrane transport
SAM40697_RS01280	COG1609	Transcriptional regulator
SAM40697_RS01285	COG1621	beta-fructofuranosidase activity
SAM40697_RS01320	COG0604	alcohol dehydrogenase
SAM40697_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS01320	COG3321	synthase
SAM40697_RS01340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SAM40697_RS01350	COG1280	lysine exporter protein (LysE YggA)
SAM40697_RS01365	COG2084	Dehydrogenase
SAM40697_RS01370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAM40697_RS01375	COG1733	regulation of RNA biosynthetic process
SAM40697_RS01390	COG1309	transcriptional regulator
SAM40697_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS01405	COG1595	DNA-templated transcription, initiation
SAM40697_RS01450	COG2197	response regulator
SAM40697_RS01455	COG4585	Histidine kinase
SAM40697_RS01475	COG0667	Aldo Keto reductase
SAM40697_RS01480	COG4221	oxidoreductase activity
SAM40697_RS01495	COG0640	Transcriptional regulator
SAM40697_RS01500	COG0477	Major facilitator Superfamily
SAM40697_RS01615	COG0523	cobalamin synthesis protein
SAM40697_RS01620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM40697_RS01625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAM40697_RS01645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM40697_RS01650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS01665	COG1309	transcriptional regulator
SAM40697_RS01675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM40697_RS01740	COG0702	epimerase
SAM40697_RS01760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM40697_RS01785	COG3844	kynureninase activity
SAM40697_RS01795	COG3483	tryptophan 2,3-dioxygenase activity
SAM40697_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS01805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM40697_RS01810	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM40697_RS01815	COG3396	Phenylacetate-CoA oxygenase
SAM40697_RS01820	COG3460	Phenylacetate-CoA oxygenase
SAM40697_RS01825	COG3396	Phenylacetate-CoA oxygenase
SAM40697_RS01850	COG0604	alcohol dehydrogenase
SAM40697_RS01860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAM40697_RS01920	COG2267	carboxylic ester hydrolase activity
SAM40697_RS01925	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SAM40697_RS01950	COG1278	Cold shock
SAM40697_RS01955	COG0738	Major facilitator superfamily
SAM40697_RS01960	COG3226	Transcriptional regulator
SAM40697_RS02020	COG4977	sequence-specific DNA binding
SAM40697_RS02070	COG0667	Aldo Keto reductase
SAM40697_RS02075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM40697_RS02085	COG1595	DNA-templated transcription, initiation
SAM40697_RS02140	COG0596	Alpha beta hydrolase
SAM40697_RS02150	COG1053	succinate dehydrogenase
SAM40697_RS02155	COG1595	DNA-templated transcription, initiation
SAM40697_RS02165	COG1819	glycosyl
SAM40697_RS02200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAM40697_RS02210	COG1609	Transcriptional regulator
SAM40697_RS02220	COG2814	Major facilitator Superfamily
SAM40697_RS02260	COG1191	sigma factor activity
SAM40697_RS02280	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS02285	COG2208	phosphoserine phosphatase activity
SAM40697_RS02285	COG2770	Histidine kinase
SAM40697_RS02305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAM40697_RS02335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SAM40697_RS02340	COG2329	Antibiotic biosynthesis monooxygenase
SAM40697_RS02360	COG4948	Mandelate Racemase Muconate Lactonizing
SAM40697_RS02365	COG2610	gluconate transmembrane transporter activity
SAM40697_RS02370	COG0583	DNA-binding transcription factor activity
SAM40697_RS02375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM40697_RS02405	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS02415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAM40697_RS02440	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM40697_RS02445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS02460	COG0154	amidase activity
SAM40697_RS02465	COG2045	Belongs to the ComB family
SAM40697_RS02490	COG4221	oxidoreductase activity
SAM40697_RS02495	COG5640	endopeptidase activity
SAM40697_RS02545	COG2124	cytochrome p450
SAM40697_RS02585	COG2353	YceI-like domain
SAM40697_RS02595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAM40697_RS02600	COG0739	heme binding
SAM40697_RS02645	COG1609	Transcriptional regulator
SAM40697_RS02655	COG0402	S-adenosylhomocysteine deaminase activity
SAM40697_RS02660	COG2233	PERMEase
SAM40697_RS02685	COG1595	DNA-templated transcription, initiation
SAM40697_RS02705	COG2375	cellular response to nickel ion
SAM40697_RS02710	COG0346	lactoylglutathione lyase activity
SAM40697_RS02740	COG0584	glycerophosphoryl diester phosphodiesterase
SAM40697_RS02760	COG3795	YCII-related domain
SAM40697_RS02765	COG4941	Belongs to the sigma-70 factor family
SAM40697_RS02780	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS02810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM40697_RS02815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM40697_RS02830	COG0584	glycerophosphoryl diester phosphodiesterase
SAM40697_RS02845	COG0516	GMP reductase activity
SAM40697_RS02845	COG0517	IMP dehydrogenase activity
SAM40697_RS02850	COG4585	Histidine kinase
SAM40697_RS02860	COG1136	(ABC) transporter
SAM40697_RS02880	COG0583	DNA-binding transcription factor activity
SAM40697_RS02890	COG0702	epimerase
SAM40697_RS02895	COG2409	Drug exporters of the RND superfamily
SAM40697_RS02920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM40697_RS02930	COG3226	Transcriptional regulator
SAM40697_RS02935	COG2391	methyltransferase activity
SAM40697_RS02940	COG0326	Molecular chaperone. Has ATPase activity
SAM40697_RS02945	COG2755	lipolytic protein G-D-S-L family
SAM40697_RS02950	COG4977	sequence-specific DNA binding
SAM40697_RS02975	COG2175	clavaminate synthase activity
SAM40697_RS02985	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS02990	COG1175	transmembrane transport
SAM40697_RS03000	COG1609	Transcriptional regulator
SAM40697_RS03005	COG1953	Uracil, thiamine, allantoin
SAM40697_RS03035	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SAM40697_RS03040	COG1082	Xylose isomerase domain protein TIM barrel
SAM40697_RS03045	COG1063	alcohol dehydrogenase
SAM40697_RS03055	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS03060	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS03095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM40697_RS03100	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM40697_RS03105	COG3396	Phenylacetate-CoA oxygenase
SAM40697_RS03110	COG3460	Phenylacetate-CoA oxygenase
SAM40697_RS03115	COG3396	Phenylacetate-CoA oxygenase
SAM40697_RS03120	COG2050	protein possibly involved in aromatic compounds catabolism
SAM40697_RS03170	COG5640	endopeptidase activity
SAM40697_RS03175	COG1119	ATPase activity
SAM40697_RS03180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SAM40697_RS03185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM40697_RS03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS03230	COG1335	isochorismatase
SAM40697_RS03305	COG0583	DNA-binding transcription factor activity
SAM40697_RS03320	COG2814	Major facilitator Superfamily
SAM40697_RS03330	COG0583	DNA-binding transcription factor activity
SAM40697_RS03335	COG5640	endopeptidase activity
SAM40697_RS03355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAM40697_RS03355	COG1017	nitric oxide dioxygenase activity
SAM40697_RS03360	COG1959	2 iron, 2 sulfur cluster binding
SAM40697_RS03420	COG1609	Transcriptional regulator
SAM40697_RS03425	COG4209	transmembrane transport
SAM40697_RS03430	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS03450	COG0110	maltose O-acetyltransferase activity
SAM40697_RS03475	COG1120	ATPase activity
SAM40697_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS03555	COG0475	glutathione-regulated potassium exporter activity
SAM40697_RS03580	COG1131	(ABC) transporter
SAM40697_RS03585	COG0142	geranyltranstransferase activity
SAM40697_RS03595	COG2770	Histidine kinase
SAM40697_RS03595	COG2208	phosphoserine phosphatase activity
SAM40697_RS03620	COG0456	acetyltransferase
SAM40697_RS03660	COG0753	catalase activity
SAM40697_RS03690	COG0009	L-threonylcarbamoyladenylate synthase
SAM40697_RS03725	COG2207	Transcriptional regulator
SAM40697_RS03735	COG2223	nitrite transmembrane transporter activity
SAM40697_RS03755	COG1793	dna ligase
SAM40697_RS03755	COG3285	dna ligase
SAM40697_RS03765	COG0181	hydroxymethylbilane synthase activity
SAM40697_RS03805	COG0366	Alpha amylase catalytic
SAM40697_RS03820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAM40697_RS03825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAM40697_RS03855	COG0784	Response regulator, receiver
SAM40697_RS03855	COG2205	protein histidine kinase activity
SAM40697_RS03855	COG5002	protein histidine kinase activity
SAM40697_RS03870	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS03875	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS03880	COG2172	sigma factor antagonist activity
SAM40697_RS03895	COG1252	NADH dehydrogenase
SAM40697_RS03930	COG1982	Orn Lys Arg decarboxylase major
SAM40697_RS03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAM40697_RS04015	COG2197	response regulator
SAM40697_RS04020	COG2340	Cysteine-rich secretory protein family
SAM40697_RS04035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM40697_RS04035	COG0515	serine threonine protein kinase
SAM40697_RS04060	COG0667	Aldo Keto reductase
SAM40697_RS04070	COG0328	RNA-DNA hybrid ribonuclease activity
SAM40697_RS04085	COG0740	serine-type endopeptidase activity
SAM40697_RS04090	COG0740	serine-type endopeptidase activity
SAM40697_RS04100	COG1191	sigma factor activity
SAM40697_RS04145	COG0667	Aldo Keto reductase
SAM40697_RS04150	COG0583	DNA-binding transcription factor activity
SAM40697_RS04160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM40697_RS04165	COG0346	lactoylglutathione lyase activity
SAM40697_RS04175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM40697_RS04180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM40697_RS04185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAM40697_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS04210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS04215	COG0431	NADPH-dependent FMN reductase
SAM40697_RS04255	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS04295	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS04300	COG2366	antibiotic biosynthetic process
SAM40697_RS04305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM40697_RS04320	COG0515	serine threonine protein kinase
SAM40697_RS04350	COG2205	protein histidine kinase activity
SAM40697_RS04355	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS04385	COG1609	Transcriptional regulator
SAM40697_RS04395	COG1556	Lactate utilization protein
SAM40697_RS04400	COG1139	Iron-sulfur cluster binding protein
SAM40697_RS04405	COG0247	lactate metabolic process
SAM40697_RS04410	COG1070	Carbohydrate kinase
SAM40697_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS04415	COG3347	Dehydrogenase
SAM40697_RS04425	COG1129	ABC transporter
SAM40697_RS04430	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAM40697_RS04450	COG1609	Transcriptional regulator
SAM40697_RS04465	COG1733	regulation of RNA biosynthetic process
SAM40697_RS04480	COG2376	Dihydroxyacetone kinase
SAM40697_RS04485	COG1461	Dihydroxyacetone kinase
SAM40697_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS04525	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAM40697_RS04525	COG1902	pentaerythritol trinitrate reductase activity
SAM40697_RS04545	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM40697_RS04555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM40697_RS04570	COG3458	cephalosporin-C deacetylase activity
SAM40697_RS04575	COG2188	Transcriptional regulator
SAM40697_RS04580	COG2226	methyltransferase
SAM40697_RS04595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SAM40697_RS04600	COG1686	Belongs to the peptidase S11 family
SAM40697_RS04610	COG1968	undecaprenyl-diphosphatase activity
SAM40697_RS04615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAM40697_RS04620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAM40697_RS04625	COG1846	Transcriptional regulator
SAM40697_RS04650	COG0137	argininosuccinate synthase activity
SAM40697_RS04660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAM40697_RS04680	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM40697_RS04690	COG1175	transmembrane transport
SAM40697_RS04695	COG1653	transport
SAM40697_RS04700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM40697_RS04700	COG3291	Pkd domain containing protein
SAM40697_RS04720	COG3250	beta-galactosidase activity
SAM40697_RS04725	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS04735	COG2182	Extracellular solute-binding protein
SAM40697_RS04745	COG1609	Transcriptional regulator
SAM40697_RS04765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS04780	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAM40697_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS04805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS04820	COG1846	Transcriptional regulator
SAM40697_RS04835	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS04855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAM40697_RS04860	COG0463	Glycosyl transferase, family 2
SAM40697_RS04895	COG1349	DNA-binding transcription factor activity
SAM40697_RS04930	COG1940	carbohydrate kinase activity
SAM40697_RS04940	COG2813	Specifically methylates the guanine in position
SAM40697_RS04950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM40697_RS04965	COG2608	mercury ion transmembrane transporter activity
SAM40697_RS05000	COG0783	Belongs to the Dps family
SAM40697_RS05015	COG1501	Belongs to the glycosyl hydrolase 31 family
SAM40697_RS05020	COG2182	Extracellular solute-binding protein
SAM40697_RS05025	COG1175	transmembrane transport
SAM40697_RS05030	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS05035	COG2723	6-phospho-beta-galactosidase activity
SAM40697_RS05060	COG2197	response regulator
SAM40697_RS05065	COG4585	Histidine kinase
SAM40697_RS05080	COG0445	tRNA wobble uridine modification
SAM40697_RS05095	COG1660	Displays ATPase and GTPase activities
SAM40697_RS05125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SAM40697_RS05145	COG0204	Acyl-transferase
SAM40697_RS05170	COG0584	glycerophosphoryl diester phosphodiesterase
SAM40697_RS05210	COG0671	phosphoesterase, PA-phosphatase related
SAM40697_RS05240	COG0640	Transcriptional regulator
SAM40697_RS05245	COG1902	pentaerythritol trinitrate reductase activity
SAM40697_RS05260	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS05270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAM40697_RS05335	COG4221	oxidoreductase activity
SAM40697_RS05345	COG0726	polysaccharide deacetylase
SAM40697_RS05355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM40697_RS05360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAM40697_RS05365	COG2080	2 iron, 2 sulfur cluster binding
SAM40697_RS05375	COG4565	transcriptional regulatory protein
SAM40697_RS05380	COG3290	protein histidine kinase activity
SAM40697_RS05400	COG0432	Pfam Uncharacterised protein family UPF0047
SAM40697_RS05405	COG2072	flavoprotein involved in K transport
SAM40697_RS05415	COG1132	(ABC) transporter
SAM40697_RS05435	COG1132	(ABC) transporter
SAM40697_RS05445	COG0254	rRNA binding
SAM40697_RS05460	COG1946	Acyl-CoA thioesterase
SAM40697_RS05470	COG2018	Roadblock/LC7 domain
SAM40697_RS05545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM40697_RS05555	COG2115	Belongs to the xylose isomerase family
SAM40697_RS05560	COG1070	Carbohydrate kinase
SAM40697_RS05565	COG1940	carbohydrate kinase activity
SAM40697_RS05565	COG1846	Transcriptional regulator
SAM40697_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS05590	COG0592	DNA-directed DNA polymerase activity
SAM40697_RS05620	COG0477	Major facilitator Superfamily
SAM40697_RS05645	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS05650	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS05660	COG1396	sequence-specific DNA binding
SAM40697_RS05660	COG3800	Transcriptional regulator
SAM40697_RS05670	COG1793	dna ligase
SAM40697_RS05680	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS05690	COG2124	cytochrome p450
SAM40697_RS05695	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS05705	COG0242	peptide deformylase activity
SAM40697_RS05715	COG3442	glutamine amidotransferase
SAM40697_RS05720	COG0205	6-phosphofructokinase activity
SAM40697_RS05730	COG3275	phosphorelay sensor kinase activity
SAM40697_RS05735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM40697_RS05745	COG3279	Response regulator of the LytR AlgR family
SAM40697_RS05750	COG1522	sequence-specific DNA binding
SAM40697_RS05755	COG1834	amidinotransferase
SAM40697_RS05760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM40697_RS05795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS05800	COG3629	intracellular signal transduction
SAM40697_RS05800	COG3903	Transcriptional regulator
SAM40697_RS05825	COG0829	nickel cation binding
SAM40697_RS05830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAM40697_RS05840	COG0804	urea catabolic process
SAM40697_RS05845	COG0832	Belongs to the urease beta subunit family
SAM40697_RS05850	COG0831	urea catabolic process
SAM40697_RS05855	COG1309	transcriptional regulator
SAM40697_RS05875	COG0740	serine-type endopeptidase activity
SAM40697_RS05910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SAM40697_RS05915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAM40697_RS05920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SAM40697_RS05925	COG2226	methyltransferase
SAM40697_RS05930	COG0456	acetyltransferase
SAM40697_RS05950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS05955	COG3663	DNA glycosylase
SAM40697_RS05975	COG4585	Histidine kinase
SAM40697_RS05980	COG2197	response regulator
SAM40697_RS05985	COG1940	carbohydrate kinase activity
SAM40697_RS05990	COG2188	Transcriptional regulator
SAM40697_RS05995	COG1595	DNA-templated transcription, initiation
SAM40697_RS06030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAM40697_RS06035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SAM40697_RS06045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SAM40697_RS06045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM40697_RS06085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM40697_RS06100	COG0626	cystathionine gamma-synthase activity
SAM40697_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS06130	COG1522	sequence-specific DNA binding
SAM40697_RS06135	COG0419	ATPase involved in DNA repair
SAM40697_RS06140	COG0420	3'-5' exonuclease activity
SAM40697_RS06145	COG1739	Uncharacterized protein family UPF0029
SAM40697_RS06150	COG0215	cysteine-tRNA ligase activity
SAM40697_RS06155	COG1832	CoA-binding protein
SAM40697_RS06170	COG0110	maltose O-acetyltransferase activity
SAM40697_RS06200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAM40697_RS06215	COG1968	undecaprenyl-diphosphatase activity
SAM40697_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS06225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SAM40697_RS06245	COG2318	DinB family
SAM40697_RS06260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAM40697_RS06295	COG0723	plastoquinol--plastocyanin reductase activity
SAM40697_RS06310	COG0697	spore germination
SAM40697_RS06345	COG0384	phenazine biosynthesis protein PhzF
SAM40697_RS06375	COG0725	ABC transporter, periplasmic molybdate-binding protein
SAM40697_RS06395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAM40697_RS06395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAM40697_RS06405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAM40697_RS06425	COG1716	ATPase activity
SAM40697_RS06445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAM40697_RS06475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAM40697_RS06485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM40697_RS06500	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SAM40697_RS06510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAM40697_RS06515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM40697_RS06530	COG2018	Roadblock/LC7 domain
SAM40697_RS06565	COG2814	Major facilitator Superfamily
SAM40697_RS06570	COG4336	lyase activity
SAM40697_RS06575	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS06580	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS06610	COG2364	Membrane
SAM40697_RS06620	COG2270	Major facilitator Superfamily
SAM40697_RS06630	COG3030	protein affecting phage T7 exclusion by the F plasmid
SAM40697_RS06635	COG1216	Glycosyl transferase, family 2
SAM40697_RS06660	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS06705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAM40697_RS06710	COG0140	phosphoribosyl-ATP diphosphatase activity
SAM40697_RS06715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAM40697_RS06720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM40697_RS06720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM40697_RS06725	COG3201	nicotinamide mononucleotide transporter
SAM40697_RS06755	COG2223	nitrite transmembrane transporter activity
SAM40697_RS06765	COG2233	PERMEase
SAM40697_RS06790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAM40697_RS06805	COG0531	amino acid
SAM40697_RS06820	COG2390	Transcriptional regulator
SAM40697_RS06825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAM40697_RS06835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAM40697_RS06850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAM40697_RS06860	COG1758	RNA polymerase activity
SAM40697_RS06865	COG0194	GDP metabolic process
SAM40697_RS06875	COG0284	orotidine-5'-phosphate decarboxylase activity
SAM40697_RS06880	COG0167	dihydroorotate dehydrogenase activity
SAM40697_RS06885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAM40697_RS06890	COG0505	Belongs to the CarA family
SAM40697_RS06900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM40697_RS06905	COG0540	Belongs to the ATCase OTCase family
SAM40697_RS06910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAM40697_RS06920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAM40697_RS06925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAM40697_RS06930	COG0006	proline dipeptidase activity
SAM40697_RS06940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAM40697_RS06945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAM40697_RS06950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAM40697_RS06955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAM40697_RS06960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAM40697_RS06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAM40697_RS06970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAM40697_RS06990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAM40697_RS07005	COG0124	histidyl-tRNA synthetase
SAM40697_RS07015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAM40697_RS07020	COG1196	nuclear chromosome segregation
SAM40697_RS07025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAM40697_RS07030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAM40697_RS07035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM40697_RS07040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM40697_RS07050	COG2255	four-way junction helicase activity
SAM40697_RS07055	COG0632	four-way junction helicase activity
SAM40697_RS07060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SAM40697_RS07065	COG0217	transcriptional regulatory protein
SAM40697_RS07070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SAM40697_RS07075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SAM40697_RS07085	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS07090	COG1560	Kdo2-lipid A biosynthetic process
SAM40697_RS07095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAM40697_RS07115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAM40697_RS07130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAM40697_RS07155	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS07160	COG1175	transmembrane transport
SAM40697_RS07215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAM40697_RS07270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAM40697_RS07270	COG1648	precorrin-2 dehydrogenase activity
SAM40697_RS07275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAM40697_RS07295	COG2011	ABC-type metal ion transport system permease component
SAM40697_RS07300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAM40697_RS07330	COG0584	glycerophosphoryl diester phosphodiesterase
SAM40697_RS07335	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS07335	COG0204	Acyl-transferase
SAM40697_RS07340	COG0477	Major facilitator Superfamily
SAM40697_RS07355	COG0165	Argininosuccinate lyase
SAM40697_RS07385	COG1438	arginine binding
SAM40697_RS07390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM40697_RS07395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAM40697_RS07400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAM40697_RS07405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAM40697_RS07440	COG0697	spore germination
SAM40697_RS07450	COG1649	PFAM Uncharacterised BCR, COG1649
SAM40697_RS07475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAM40697_RS07475	COG0072	phenylalanine-tRNA ligase activity
SAM40697_RS07480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAM40697_RS07485	COG5002	protein histidine kinase activity
SAM40697_RS07490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAM40697_RS07495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAM40697_RS07500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAM40697_RS07505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAM40697_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS07560	COG0174	glutamine synthetase
SAM40697_RS07570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM40697_RS07595	COG4176	ABC-type proline glycine betaine transport system permease component
SAM40697_RS07600	COG4175	Glycine betaine
SAM40697_RS07600	COG0517	IMP dehydrogenase activity
SAM40697_RS07605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM40697_RS07620	COG0564	pseudouridine synthase activity
SAM40697_RS07655	COG0805	protein transport
SAM40697_RS07660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM40697_RS07690	COG0545	Peptidyl-prolyl cis-trans isomerase
SAM40697_RS07695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM40697_RS07705	COG1609	Transcriptional regulator
SAM40697_RS07710	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM40697_RS07715	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAM40697_RS07725	COG4122	O-methyltransferase activity
SAM40697_RS07730	COG1222	aaa ATPase
SAM40697_RS07750	COG0517	IMP dehydrogenase activity
SAM40697_RS07750	COG1994	Peptidase M50
SAM40697_RS07760	COG2197	response regulator
SAM40697_RS07765	COG4166	transmembrane transport
SAM40697_RS07775	COG1410	methionine synthase
SAM40697_RS07775	COG0646	methionine synthase
SAM40697_RS07780	COG1414	Transcriptional regulator
SAM40697_RS07785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAM40697_RS07790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM40697_RS07795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAM40697_RS07800	COG2186	Transcriptional regulator
SAM40697_RS07810	COG0215	cysteine-tRNA ligase activity
SAM40697_RS07825	COG0406	alpha-ribazole phosphatase activity
SAM40697_RS07830	COG0598	Magnesium transport protein CorA
SAM40697_RS07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS07845	COG0667	Aldo Keto reductase
SAM40697_RS07885	COG3012	SEC-C Motif Domain Protein
SAM40697_RS07890	COG2186	Transcriptional regulator
SAM40697_RS07895	COG3265	gluconokinase activity
SAM40697_RS07920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAM40697_RS07925	COG2149	membrane
SAM40697_RS07960	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS07970	COG3876	Protein conserved in bacteria
SAM40697_RS08010	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS08020	COG0640	Transcriptional regulator
SAM40697_RS08040	COG3842	ATPase activity
SAM40697_RS08050	COG2851	Citrate transporter
SAM40697_RS08055	COG0243	molybdopterin cofactor binding
SAM40697_RS08060	COG1309	transcriptional regulator
SAM40697_RS08070	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SAM40697_RS08075	COG2188	Transcriptional regulator
SAM40697_RS08095	COG1595	DNA-templated transcription, initiation
SAM40697_RS08115	COG0515	serine threonine protein kinase
SAM40697_RS08115	COG2815	serine threonine protein kinase
SAM40697_RS08120	COG2755	lipolytic protein G-D-S-L family
SAM40697_RS08125	COG0463	Glycosyl transferase, family 2
SAM40697_RS08150	COG1725	Transcriptional regulator
SAM40697_RS08165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAM40697_RS08165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAM40697_RS08185	COG0662	Cupin 2, conserved barrel domain protein
SAM40697_RS08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAM40697_RS08195	COG0587	DNA-directed DNA polymerase activity
SAM40697_RS08225	COG1799	cell septum assembly
SAM40697_RS08230	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS08235	COG0477	Major facilitator Superfamily
SAM40697_RS08245	COG0671	phosphoesterase, PA-phosphatase related
SAM40697_RS08270	COG1160	GTP binding
SAM40697_RS08280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAM40697_RS08320	COG1187	pseudouridine synthase activity
SAM40697_RS08325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAM40697_RS08345	COG0686	Belongs to the AlaDH PNT family
SAM40697_RS08355	COG0494	nUDIX hydrolase
SAM40697_RS08360	COG0504	CTP synthase activity
SAM40697_RS08365	COG3387	PFAM Glycoside hydrolase 15-related
SAM40697_RS08425	COG2208	phosphoserine phosphatase activity
SAM40697_RS08425	COG2770	Histidine kinase
SAM40697_RS08440	COG0497	DNA recombination
SAM40697_RS08445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAM40697_RS08465	COG1120	ATPase activity
SAM40697_RS08470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS08475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS08480	COG0647	UMP catabolic process
SAM40697_RS08515	COG2094	Belongs to the DNA glycosylase MPG family
SAM40697_RS08525	COG1881	PFAM PEBP family protein
SAM40697_RS08545	COG1119	ATPase activity
SAM40697_RS08560	COG2197	response regulator
SAM40697_RS08565	COG4585	Histidine kinase
SAM40697_RS08570	COG4221	oxidoreductase activity
SAM40697_RS08585	COG1716	ATPase activity
SAM40697_RS08585	COG0842	Transport permease protein
SAM40697_RS08585	COG1131	(ABC) transporter
SAM40697_RS08595	COG3830	Belongs to the UPF0237 family
SAM40697_RS08595	COG0560	Phosphoserine phosphatase
SAM40697_RS08600	COG0588	phosphoglycerate mutase activity
SAM40697_RS08615	COG2186	Transcriptional regulator
SAM40697_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS08645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAM40697_RS08665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAM40697_RS08670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM40697_RS08685	COG1404	Belongs to the peptidase S8 family
SAM40697_RS08690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM40697_RS08700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM40697_RS08715	COG3387	PFAM Glycoside hydrolase 15-related
SAM40697_RS08755	COG1024	Enoyl-CoA hydratase
SAM40697_RS08765	COG0488	(ABC) transporter
SAM40697_RS08785	COG0235	Class ii aldolase
SAM40697_RS08800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SAM40697_RS08805	COG1492	cobalamin metabolic process
SAM40697_RS08825	COG1797	cobyrinic acid a,c-diamide synthase activity
SAM40697_RS08860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SAM40697_RS08885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAM40697_RS08890	COG0456	acetyltransferase
SAM40697_RS08895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAM40697_RS08900	COG1917	Cupin 2, conserved barrel domain protein
SAM40697_RS08905	COG5285	phytanoyl-CoA dioxygenase
SAM40697_RS08935	COG1414	Transcriptional regulator
SAM40697_RS08950	COG1595	DNA-templated transcription, initiation
SAM40697_RS08965	COG4677	pectinesterase activity
SAM40697_RS08970	COG3866	Pectate lyase
SAM40697_RS08975	COG2755	lipolytic protein G-D-S-L family
SAM40697_RS08990	COG3507	Belongs to the glycosyl hydrolase 43 family
SAM40697_RS09005	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS09025	COG1802	Transcriptional regulator
SAM40697_RS09045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM40697_RS09050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM40697_RS09055	COG1349	DNA-binding transcription factor activity
SAM40697_RS09070	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS09075	COG1063	alcohol dehydrogenase
SAM40697_RS09085	COG1309	transcriptional regulator
SAM40697_RS09125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM40697_RS09135	COG2171	N-acyltransferase activity
SAM40697_RS09140	COG3226	Transcriptional regulator
SAM40697_RS09145	COG2076	Multidrug Resistance protein
SAM40697_RS09150	COG2151	metal-sulfur cluster biosynthetic enzyme
SAM40697_RS09155	COG0822	iron-sulfur transferase activity
SAM40697_RS09160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM40697_RS09165	COG0396	ATPase activity
SAM40697_RS09175	COG0719	Fe-S assembly protein
SAM40697_RS09190	COG2746	aminoglycoside 3-N-acetyltransferase activity
SAM40697_RS09205	COG1612	heme a metabolic process
SAM40697_RS09220	COG0109	protoheme IX farnesyltransferase activity
SAM40697_RS09230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAM40697_RS09245	COG0363	glucosamine-6-phosphate deaminase activity
SAM40697_RS09250	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS09255	COG1175	transmembrane transport
SAM40697_RS09260	COG1653	transport
SAM40697_RS09265	COG0366	Alpha amylase catalytic
SAM40697_RS09270	COG1653	transport
SAM40697_RS09275	COG1695	Transcriptional regulator
SAM40697_RS09280	COG1136	(ABC) transporter
SAM40697_RS09290	COG0166	Belongs to the GPI family
SAM40697_RS09300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAM40697_RS09305	COG0149	triose-phosphate isomerase activity
SAM40697_RS09310	COG0126	phosphoglycerate kinase activity
SAM40697_RS09315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAM40697_RS09325	COG1481	regulation of sporulation
SAM40697_RS09330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAM40697_RS09335	COG1660	Displays ATPase and GTPase activities
SAM40697_RS09340	COG0322	excinuclease ABC activity
SAM40697_RS09355	COG1609	Transcriptional regulator
SAM40697_RS09375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM40697_RS09390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SAM40697_RS09395	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAM40697_RS09400	COG0387	Pfam Sodium calcium exchanger
SAM40697_RS09420	COG0556	nucleotide-excision repair
SAM40697_RS09430	COG0584	glycerophosphoryl diester phosphodiesterase
SAM40697_RS09445	COG2313	pseudouridylate synthase activity
SAM40697_RS09450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAM40697_RS09450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAM40697_RS09455	COG2226	methyltransferase
SAM40697_RS09460	COG0598	Magnesium transport protein CorA
SAM40697_RS09520	COG0402	S-adenosylhomocysteine deaminase activity
SAM40697_RS09565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM40697_RS09585	COG0237	dephospho-CoA kinase activity
SAM40697_RS09600	COG2226	methyltransferase
SAM40697_RS09605	COG1643	Atp-dependent helicase
SAM40697_RS09635	COG2050	protein possibly involved in aromatic compounds catabolism
SAM40697_RS09695	COG0737	Belongs to the 5'-nucleotidase family
SAM40697_RS09715	COG0287	Prephenate dehydrogenase
SAM40697_RS09715	COG1605	Chorismate mutase
SAM40697_RS09735	COG2304	oxidoreductase activity
SAM40697_RS09755	COG0067	glutamate synthase
SAM40697_RS09755	COG0070	glutamate synthase
SAM40697_RS09755	COG0069	glutamate synthase activity
SAM40697_RS09785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM40697_RS09790	COG2301	Belongs to the HpcH HpaI aldolase family
SAM40697_RS09795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAM40697_RS09805	COG0159	tryptophan synthase activity
SAM40697_RS09810	COG0133	tryptophan synthase activity
SAM40697_RS09815	COG0134	indole-3-glycerol-phosphate synthase activity
SAM40697_RS09840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SAM40697_RS09855	COG0107	imidazoleglycerol-phosphate synthase activity
SAM40697_RS09860	COG0251	oxidation-reduction process
SAM40697_RS09865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAM40697_RS09870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAM40697_RS09875	COG0131	Imidazoleglycerol-phosphate dehydratase
SAM40697_RS09880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM40697_RS09885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAM40697_RS09905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAM40697_RS09925	COG1432	Conserved Protein
SAM40697_RS09930	COG0587	DNA-directed DNA polymerase activity
SAM40697_RS09970	COG2153	protein acetylation
SAM40697_RS09990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAM40697_RS10000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAM40697_RS10005	COG3599	regulation of cell shape
SAM40697_RS10015	COG1799	cell septum assembly
SAM40697_RS10025	COG1496	oxidoreductase activity
SAM40697_RS10030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAM40697_RS10035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAM40697_RS10040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAM40697_RS10050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAM40697_RS10055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAM40697_RS10065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAM40697_RS10070	COG0768	penicillin binding
SAM40697_RS10080	COG0275	rRNA processing
SAM40697_RS10090	COG0714	Associated with various cellular activities
SAM40697_RS10110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM40697_RS10120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM40697_RS10130	COG1309	transcriptional regulator
SAM40697_RS10150	COG0352	thiamine-phosphate diphosphorylase activity
SAM40697_RS10170	COG2022	thiamine diphosphate biosynthetic process
SAM40697_RS10170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM40697_RS10180	COG2022	thiamine diphosphate biosynthetic process
SAM40697_RS10185	COG2815	serine threonine protein kinase
SAM40697_RS10185	COG0515	serine threonine protein kinase
SAM40697_RS10190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAM40697_RS10195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAM40697_RS10200	COG2193	ferroxidase activity
SAM40697_RS10210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SAM40697_RS10225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAM40697_RS10230	COG0205	6-phosphofructokinase activity
SAM40697_RS10235	COG2197	response regulator
SAM40697_RS10240	COG4585	Histidine kinase
SAM40697_RS10265	COG1940	carbohydrate kinase activity
SAM40697_RS10275	COG0003	Pfam Anion-transporting ATPase
SAM40697_RS10345	COG2205	protein histidine kinase activity
SAM40697_RS10350	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS10360	COG1929	Belongs to the glycerate kinase type-1 family
SAM40697_RS10365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAM40697_RS10370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAM40697_RS10375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SAM40697_RS10380	COG0723	plastoquinol--plastocyanin reductase activity
SAM40697_RS10385	COG2010	Cytochrome c
SAM40697_RS10390	COG1845	cytochrome c oxidase, subunit III
SAM40697_RS10400	COG1376	ErfK ybiS ycfS ynhG family protein
SAM40697_RS10410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAM40697_RS10415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAM40697_RS10425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM40697_RS10445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAM40697_RS10450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SAM40697_RS10455	COG2197	response regulator
SAM40697_RS10460	COG4585	Histidine kinase
SAM40697_RS10485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM40697_RS10505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAM40697_RS10515	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SAM40697_RS10525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAM40697_RS10530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAM40697_RS10535	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM40697_RS10545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM40697_RS10565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM40697_RS10575	COG1090	epimerase
SAM40697_RS10590	COG0321	lipoyl(octanoyl) transferase activity
SAM40697_RS10595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAM40697_RS10615	COG0174	glutamine synthetase
SAM40697_RS10660	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS10675	COG2197	response regulator
SAM40697_RS10700	COG1309	transcriptional regulator
SAM40697_RS10725	COG0366	Alpha amylase catalytic
SAM40697_RS10730	COG3833	ABC-type maltose transport systems, permease component
SAM40697_RS10735	COG1175	transmembrane transport
SAM40697_RS10745	COG1609	Transcriptional regulator
SAM40697_RS10755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAM40697_RS10760	COG2161	toxin-antitoxin pair type II binding
SAM40697_RS10765	COG4115	mRNA cleavage
SAM40697_RS10775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAM40697_RS10775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAM40697_RS10790	COG0174	glutamine synthetase
SAM40697_RS10800	COG2814	Major facilitator Superfamily
SAM40697_RS10810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAM40697_RS10830	COG1994	Peptidase M50
SAM40697_RS10890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS10895	COG1120	ATPase activity
SAM40697_RS10925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM40697_RS10930	COG2814	Major facilitator Superfamily
SAM40697_RS10940	COG3540	Alkaline phosphatase
SAM40697_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS10980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SAM40697_RS11015	COG0515	serine threonine protein kinase
SAM40697_RS11015	COG2815	serine threonine protein kinase
SAM40697_RS11050	COG3022	response to hydroperoxide
SAM40697_RS11055	COG0800	Aldolase
SAM40697_RS11070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAM40697_RS11080	COG2030	dehydratase
SAM40697_RS11085	COG4585	Histidine kinase
SAM40697_RS11095	COG2197	response regulator
SAM40697_RS11105	COG0477	Major facilitator Superfamily
SAM40697_RS11115	COG2247	cell wall binding repeat
SAM40697_RS11115	COG0860	N-Acetylmuramoyl-L-alanine amidase
SAM40697_RS11145	COG1309	transcriptional regulator
SAM40697_RS11150	COG1657	PFAM Prenyltransferase squalene oxidase
SAM40697_RS11165	COG3845	ABC transporter
SAM40697_RS11190	COG1335	isochorismatase
SAM40697_RS11255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM40697_RS11275	COG2259	Doxx family
SAM40697_RS11320	COG0586	Pfam SNARE associated Golgi protein
SAM40697_RS11330	COG1358	cellular component organization or biogenesis
SAM40697_RS11375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAM40697_RS11380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM40697_RS11390	COG0477	Major facilitator Superfamily
SAM40697_RS11395	COG1309	transcriptional regulator
SAM40697_RS11410	COG0667	Aldo Keto reductase
SAM40697_RS11415	COG0789	Transcriptional regulator
SAM40697_RS11460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM40697_RS11465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM40697_RS11470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS11510	COG1764	response to oxidative stress
SAM40697_RS11515	COG2130	NADP-dependent
SAM40697_RS11550	COG1129	ABC transporter
SAM40697_RS11555	COG4214	carbohydrate transport
SAM40697_RS11565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM40697_RS11570	COG3507	Belongs to the glycosyl hydrolase 43 family
SAM40697_RS11575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SAM40697_RS11600	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS11605	COG1175	transmembrane transport
SAM40697_RS11635	COG3386	PFAM SMP-30 Gluconolaconase
SAM40697_RS11640	COG1414	Transcriptional regulator
SAM40697_RS11655	COG2186	Transcriptional regulator
SAM40697_RS11665	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS11670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAM40697_RS11670	COG0825	malonyl-CoA metabolic process
SAM40697_RS11695	COG0515	serine threonine protein kinase
SAM40697_RS11695	COG2815	serine threonine protein kinase
SAM40697_RS11700	COG1077	Cell shape determining protein MreB Mrl
SAM40697_RS11735	COG1070	Carbohydrate kinase
SAM40697_RS11760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM40697_RS11765	COG0358	DNA primase activity
SAM40697_RS11775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SAM40697_RS11785	COG2949	membrane
SAM40697_RS11790	COG0243	molybdopterin cofactor binding
SAM40697_RS11820	COG1733	regulation of RNA biosynthetic process
SAM40697_RS11845	COG2146	nitrite reductase [NAD(P)H] activity
SAM40697_RS11845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAM40697_RS11870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SAM40697_RS11875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAM40697_RS11875	COG0574	Belongs to the PEP-utilizing enzyme family
SAM40697_RS11895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAM40697_RS11915	COG0423	glycine-tRNA ligase activity
SAM40697_RS11920	COG3443	Belongs to the bacterial solute-binding protein 9 family
SAM40697_RS11920	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAM40697_RS11925	COG1121	(ABC) transporter
SAM40697_RS11930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAM40697_RS11940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM40697_RS11945	COG1381	Involved in DNA repair and RecF pathway recombination
SAM40697_RS11965	COG2197	response regulator
SAM40697_RS11970	COG4585	Histidine kinase
SAM40697_RS11975	COG2409	Drug exporters of the RND superfamily
SAM40697_RS12020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAM40697_RS12045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAM40697_RS12055	COG2315	Protein conserved in bacteria
SAM40697_RS12065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAM40697_RS12070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM40697_RS12080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM40697_RS12085	COG1234	tRNA 3'-trailer cleavage
SAM40697_RS12090	COG0537	adenosine 5'-monophosphoramidase activity
SAM40697_RS12095	COG0793	Belongs to the peptidase S41A family
SAM40697_RS12095	COG4946	Tricorn protease homolog
SAM40697_RS12120	COG0484	heat shock protein binding
SAM40697_RS12125	COG1420	regulation of RNA biosynthetic process
SAM40697_RS12155	COG0481	GTPase activity
SAM40697_RS12160	COG0268	Binds directly to 16S ribosomal RNA
SAM40697_RS12175	COG2353	YceI-like domain
SAM40697_RS12180	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SAM40697_RS12185	COG1234	tRNA 3'-trailer cleavage
SAM40697_RS12190	COG1555	photosystem II stabilization
SAM40697_RS12195	COG1307	EDD domain protein, DegV family
SAM40697_RS12205	COG0495	leucyl-tRNA aminoacylation
SAM40697_RS12215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAM40697_RS12235	COG0588	phosphoglycerate mutase activity
SAM40697_RS12240	COG0799	negative regulation of ribosome biogenesis
SAM40697_RS12250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAM40697_RS12255	COG0501	Belongs to the peptidase M48B family
SAM40697_RS12270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SAM40697_RS12280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SAM40697_RS12295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS12300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS12305	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS12310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAM40697_RS12315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAM40697_RS12320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAM40697_RS12325	COG0371	Dehydrogenase
SAM40697_RS12330	COG1530	ribonuclease E activity
SAM40697_RS12355	COG0772	Belongs to the SEDS family
SAM40697_RS12360	COG0768	penicillin binding
SAM40697_RS12375	COG1077	Cell shape determining protein MreB Mrl
SAM40697_RS12380	COG0105	UTP biosynthetic process
SAM40697_RS12390	COG0285	dihydrofolate synthase activity
SAM40697_RS12395	COG0525	valine-tRNA ligase activity
SAM40697_RS12405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAM40697_RS12410	COG0740	serine-type endopeptidase activity
SAM40697_RS12415	COG0740	serine-type endopeptidase activity
SAM40697_RS12420	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAM40697_RS12440	COG3594	Acyltransferase
SAM40697_RS12455	COG4552	Acetyltransferase involved in intracellular survival and related
SAM40697_RS12470	COG1113	amino acid transport
SAM40697_RS12475	COG1268	BioY protein
SAM40697_RS12480	COG1113	amino acid transport
SAM40697_RS12485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAM40697_RS12500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAM40697_RS12555	COG0697	spore germination
SAM40697_RS12560	COG1846	Transcriptional regulator
SAM40697_RS12580	COG3291	Pkd domain containing protein
SAM40697_RS12580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM40697_RS12590	COG1136	(ABC) transporter
SAM40697_RS12610	COG0668	transmembrane transport
SAM40697_RS12620	COG1486	melibiose metabolic process
SAM40697_RS12635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM40697_RS12665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAM40697_RS12670	COG2346	COG2346, Truncated hemoglobins
SAM40697_RS12700	COG0629	single-stranded DNA binding
SAM40697_RS12720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM40697_RS12735	COG2304	oxidoreductase activity
SAM40697_RS12765	COG0297	glycogen (starch) synthase activity
SAM40697_RS12770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAM40697_RS12875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM40697_RS12900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAM40697_RS12910	COG1595	DNA-templated transcription, initiation
SAM40697_RS12925	COG1129	ABC transporter
SAM40697_RS12930	COG1879	ABC-type sugar transport system periplasmic component
SAM40697_RS12935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM40697_RS12940	COG1869	D-ribose catabolic process
SAM40697_RS12955	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS12960	COG1609	Transcriptional regulator
SAM40697_RS12985	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM40697_RS13035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM40697_RS13035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM40697_RS13040	COG2356	endonuclease I
SAM40697_RS13045	COG0028	Belongs to the TPP enzyme family
SAM40697_RS13055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM40697_RS13075	COG1946	Acyl-CoA thioesterase
SAM40697_RS13085	COG1309	transcriptional regulator
SAM40697_RS13090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS13105	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS13125	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAM40697_RS13155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM40697_RS13160	COG0589	response to stress
SAM40697_RS13170	COG4977	sequence-specific DNA binding
SAM40697_RS13175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SAM40697_RS13200	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS13210	COG3469	chitinase activity
SAM40697_RS13220	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS13230	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM40697_RS13245	COG0406	alpha-ribazole phosphatase activity
SAM40697_RS13270	COG1846	Transcriptional regulator
SAM40697_RS13290	COG0028	Belongs to the TPP enzyme family
SAM40697_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS13310	COG2267	carboxylic ester hydrolase activity
SAM40697_RS13315	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
SAM40697_RS13325	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS13330	COG0477	Major facilitator Superfamily
SAM40697_RS13350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS13410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM40697_RS13415	COG0765	amino acid transport
SAM40697_RS13420	COG0765	amino acid transport
SAM40697_RS13425	COG1126	abc transporter atp-binding protein
SAM40697_RS13495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM40697_RS13500	COG2188	Transcriptional regulator
SAM40697_RS13520	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS13525	COG4702	Belongs to the UPF0303 family
SAM40697_RS13540	COG0706	membrane insertase activity
SAM40697_RS13615	COG2814	Major facilitator Superfamily
SAM40697_RS13620	COG2733	membrane
SAM40697_RS13650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM40697_RS13685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAM40697_RS13695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SAM40697_RS13700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAM40697_RS13705	COG1263	PTS System
SAM40697_RS13710	COG1263	PTS System
SAM40697_RS13715	COG1234	tRNA 3'-trailer cleavage
SAM40697_RS13740	COG1113	amino acid transport
SAM40697_RS13750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SAM40697_RS13760	COG1335	isochorismatase
SAM40697_RS13780	COG1714	RDD family
SAM40697_RS13800	COG0277	FAD linked oxidase domain protein
SAM40697_RS13810	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAM40697_RS13820	COG1174	glycine betaine transport
SAM40697_RS13830	COG1174	glycine betaine transport
SAM40697_RS13840	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAM40697_RS13860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM40697_RS13875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAM40697_RS13880	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS13885	COG1175	transmembrane transport
SAM40697_RS13900	COG1678	Uncharacterized ACR, COG1678
SAM40697_RS13905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAM40697_RS13910	COG0776	regulation of translation
SAM40697_RS13920	COG3973	AAA domain
SAM40697_RS13950	COG2223	nitrite transmembrane transporter activity
SAM40697_RS13985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAM40697_RS13990	COG0793	Belongs to the peptidase S41A family
SAM40697_RS14000	COG2884	Cell division ATP-binding protein ftsE
SAM40697_RS14015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAM40697_RS14020	COG0515	serine threonine protein kinase
SAM40697_RS14025	COG0515	serine threonine protein kinase
SAM40697_RS14040	COG1175	transmembrane transport
SAM40697_RS14045	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS14050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS14055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS14060	COG1216	Glycosyl transferase, family 2
SAM40697_RS14075	COG1764	response to oxidative stress
SAM40697_RS14080	COG1846	Transcriptional regulator
SAM40697_RS14105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS14110	COG1216	Glycosyl transferase, family 2
SAM40697_RS14140	COG2902	Dehydrogenase
SAM40697_RS14160	COG0653	protein targeting
SAM40697_RS14170	COG3214	Protein conserved in bacteria
SAM40697_RS14175	COG2197	response regulator
SAM40697_RS14180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SAM40697_RS14190	COG0823	Involved in the tonB-independent uptake of proteins
SAM40697_RS14195	COG5002	protein histidine kinase activity
SAM40697_RS14200	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS14205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SAM40697_RS14225	COG0714	Associated with various cellular activities
SAM40697_RS14265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SAM40697_RS14275	COG1482	cell wall glycoprotein biosynthetic process
SAM40697_RS14285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM40697_RS14290	COG1620	l-lactate permease
SAM40697_RS14330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAM40697_RS14335	COG0778	Nitroreductase
SAM40697_RS14335	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SAM40697_RS14360	COG1316	TRANSCRIPTIONal
SAM40697_RS14365	COG1316	TRANSCRIPTIONal
SAM40697_RS14370	COG1316	TRANSCRIPTIONal
SAM40697_RS14375	COG1316	TRANSCRIPTIONal
SAM40697_RS14380	COG1316	TRANSCRIPTIONal
SAM40697_RS14390	COG1316	TRANSCRIPTIONal
SAM40697_RS14395	COG1316	TRANSCRIPTIONal
SAM40697_RS14410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAM40697_RS14435	COG0789	Transcriptional regulator
SAM40697_RS14440	COG1902	pentaerythritol trinitrate reductase activity
SAM40697_RS14465	COG2205	protein histidine kinase activity
SAM40697_RS14470	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS14475	COG3104	oligopeptide transport
SAM40697_RS14485	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS14490	COG1191	sigma factor activity
SAM40697_RS14500	COG1228	amidohydrolase
SAM40697_RS14515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SAM40697_RS14545	COG2755	lipolytic protein G-D-S-L family
SAM40697_RS14550	COG0183	Belongs to the thiolase family
SAM40697_RS14585	COG1136	(ABC) transporter
SAM40697_RS14590	COG0577	efflux transmembrane transporter activity
SAM40697_RS14590	COG1136	(ABC) transporter
SAM40697_RS14595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAM40697_RS14600	COG1252	NADH dehydrogenase
SAM40697_RS14620	COG0148	phosphopyruvate hydratase activity
SAM40697_RS14680	COG0577	efflux transmembrane transporter activity
SAM40697_RS14685	COG1136	(ABC) transporter
SAM40697_RS14690	COG2814	Major facilitator Superfamily
SAM40697_RS14700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM40697_RS14730	COG4585	Histidine kinase
SAM40697_RS14735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAM40697_RS14740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAM40697_RS14745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SAM40697_RS14750	COG0193	aminoacyl-tRNA hydrolase activity
SAM40697_RS14760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SAM40697_RS14770	COG1309	transcriptional regulator
SAM40697_RS14780	COG4106	trans-aconitate 2-methyltransferase activity
SAM40697_RS14790	COG2197	response regulator
SAM40697_RS14800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAM40697_RS14840	COG0488	(ABC) transporter
SAM40697_RS14845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAM40697_RS14850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAM40697_RS14860	COG0084	hydrolase, TatD family'
SAM40697_RS14895	COG0310	cobalt ion transport
SAM40697_RS14905	COG1122	ATPase activity
SAM40697_RS14910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAM40697_RS14925	COG0442	prolyl-tRNA aminoacylation
SAM40697_RS14935	COG1595	DNA-templated transcription, initiation
SAM40697_RS14940	COG2409	Drug exporters of the RND superfamily
SAM40697_RS14950	COG0793	Belongs to the peptidase S41A family
SAM40697_RS14950	COG4946	Tricorn protease homolog
SAM40697_RS14965	COG2267	carboxylic ester hydrolase activity
SAM40697_RS14970	COG2072	flavoprotein involved in K transport
SAM40697_RS14975	COG0789	Transcriptional regulator
SAM40697_RS14980	COG0708	Exodeoxyribonuclease III
SAM40697_RS15000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM40697_RS15005	COG0315	cyclic pyranopterin monophosphate synthase activity
SAM40697_RS15005	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAM40697_RS15010	COG0315	cyclic pyranopterin monophosphate synthase activity
SAM40697_RS15020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAM40697_RS15025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAM40697_RS15035	COG3263	regulation of cellular component size
SAM40697_RS15045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SAM40697_RS15055	COG1970	mechanosensitive ion channel activity
SAM40697_RS15070	COG3191	aminopeptidase activity
SAM40697_RS15085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAM40697_RS15085	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SAM40697_RS15085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAM40697_RS15095	COG1349	DNA-binding transcription factor activity
SAM40697_RS15115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM40697_RS15120	COG3384	dioxygenase
SAM40697_RS15125	COG1846	Transcriptional regulator
SAM40697_RS15145	COG1414	Transcriptional regulator
SAM40697_RS15185	COG1309	transcriptional regulator
SAM40697_RS15190	COG4257	antibiotic catabolic process
SAM40697_RS15195	COG0110	maltose O-acetyltransferase activity
SAM40697_RS15215	COG0386	Belongs to the glutathione peroxidase family
SAM40697_RS15240	COG1686	Belongs to the peptidase S11 family
SAM40697_RS15295	COG2365	Tyrosine phosphatase family
SAM40697_RS15310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM40697_RS15330	COG3629	intracellular signal transduction
SAM40697_RS15330	COG3903	Transcriptional regulator
SAM40697_RS15340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM40697_RS15340	COG0515	serine threonine protein kinase
SAM40697_RS15350	COG1309	transcriptional regulator
SAM40697_RS15355	COG1522	sequence-specific DNA binding
SAM40697_RS15360	COG1280	lysine exporter protein (LysE YggA)
SAM40697_RS15370	COG0259	pyridoxamine-phosphate oxidase activity
SAM40697_RS15380	COG2072	flavoprotein involved in K transport
SAM40697_RS15385	COG2271	Major facilitator Superfamily
SAM40697_RS15405	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS15410	COG1595	DNA-templated transcription, initiation
SAM40697_RS15455	COG0596	Alpha beta hydrolase
SAM40697_RS15455	COG2945	thiolester hydrolase activity
SAM40697_RS15465	COG4821	SIS domain
SAM40697_RS15480	COG0259	pyridoxamine-phosphate oxidase activity
SAM40697_RS15495	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS15510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS15525	COG5006	permease, DMT superfamily
SAM40697_RS15540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAM40697_RS15545	COG0277	FAD linked oxidase domain protein
SAM40697_RS15545	COG0247	lactate metabolic process
SAM40697_RS15550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SAM40697_RS15580	COG0667	Aldo Keto reductase
SAM40697_RS15605	COG2252	PERMEase
SAM40697_RS15615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAM40697_RS15630	COG2814	Major facilitator Superfamily
SAM40697_RS15640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAM40697_RS15645	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAM40697_RS15650	COG1278	Cold shock
SAM40697_RS15680	COG1061	Type III restriction enzyme res subunit
SAM40697_RS15690	COG3973	AAA domain
SAM40697_RS15695	COG3142	Participates in the control of copper homeostasis
SAM40697_RS15725	COG1737	Transcriptional regulator
SAM40697_RS15730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAM40697_RS15755	COG0459	protein refolding
SAM40697_RS15760	COG1278	Cold shock
SAM40697_RS15775	COG0463	Glycosyl transferase, family 2
SAM40697_RS15800	COG1940	carbohydrate kinase activity
SAM40697_RS15835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAM40697_RS15845	COG2197	response regulator
SAM40697_RS15865	COG0494	nUDIX hydrolase
SAM40697_RS15900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAM40697_RS15900	COG1672	PFAM Archaeal ATPase
SAM40697_RS15915	COG0464	growth
SAM40697_RS16000	COG3842	ATPase activity
SAM40697_RS16020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAM40697_RS16025	COG0215	cysteine-tRNA ligase activity
SAM40697_RS16030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SAM40697_RS16035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAM40697_RS16040	COG1329	Transcriptional regulator
SAM40697_RS16055	COG5002	protein histidine kinase activity
SAM40697_RS16125	COG0588	phosphoglycerate mutase activity
SAM40697_RS16150	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS16185	COG1733	regulation of RNA biosynthetic process
SAM40697_RS16200	COG0546	phosphoglycolate phosphatase activity
SAM40697_RS16205	COG2188	Transcriptional regulator
SAM40697_RS16225	COG4552	Acetyltransferase involved in intracellular survival and related
SAM40697_RS16240	COG1490	D-aminoacyl-tRNA deacylase activity
SAM40697_RS16250	COG0735	belongs to the Fur family
SAM40697_RS16255	COG3485	protocatechuate 3,4-dioxygenase
SAM40697_RS16275	COG2897	thiosulfate sulfurtransferase activity
SAM40697_RS16300	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS16305	COG1609	Transcriptional regulator
SAM40697_RS16310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM40697_RS16315	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS16345	COG0737	Belongs to the 5'-nucleotidase family
SAM40697_RS16350	COG0456	acetyltransferase
SAM40697_RS16380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAM40697_RS16390	COG0494	nUDIX hydrolase
SAM40697_RS16390	COG0406	alpha-ribazole phosphatase activity
SAM40697_RS16410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAM40697_RS16415	COG0306	phosphate transporter
SAM40697_RS16425	COG1937	Protein conserved in bacteria
SAM40697_RS16435	COG0277	FAD linked oxidase domain protein
SAM40697_RS16440	COG0671	phosphoesterase, PA-phosphatase related
SAM40697_RS16445	COG1196	nuclear chromosome segregation
SAM40697_RS16445	COG0739	heme binding
SAM40697_RS16445	COG0741	lytic transglycosylase activity
SAM40697_RS16485	COG4585	Histidine kinase
SAM40697_RS16490	COG2197	response regulator
SAM40697_RS16525	COG1252	NADH dehydrogenase
SAM40697_RS16550	COG0579	oxidoreductase
SAM40697_RS16555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAM40697_RS16565	COG0667	Aldo Keto reductase
SAM40697_RS16585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAM40697_RS16585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAM40697_RS16590	COG2208	phosphoserine phosphatase activity
SAM40697_RS16590	COG2770	Histidine kinase
SAM40697_RS16595	COG0596	Alpha beta hydrolase
SAM40697_RS16650	COG1643	Atp-dependent helicase
SAM40697_RS16685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAM40697_RS16720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAM40697_RS16725	COG0047	phosphoribosylformylglycinamidine synthase activity
SAM40697_RS16730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAM40697_RS16760	COG3851	Histidine kinase
SAM40697_RS16765	COG2197	response regulator
SAM40697_RS16775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAM40697_RS16790	COG0151	Belongs to the GarS family
SAM40697_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS16865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAM40697_RS16895	COG1191	sigma factor activity
SAM40697_RS16900	COG1191	sigma factor activity
SAM40697_RS16915	COG0477	Major facilitator Superfamily
SAM40697_RS16920	COG2353	YceI-like domain
SAM40697_RS16950	COG0477	Major facilitator Superfamily
SAM40697_RS16955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAM40697_RS16965	COG2205	protein histidine kinase activity
SAM40697_RS16970	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS16990	COG1733	regulation of RNA biosynthetic process
SAM40697_RS16995	COG0768	penicillin binding
SAM40697_RS17015	COG0784	Response regulator, receiver
SAM40697_RS17020	COG1309	transcriptional regulator
SAM40697_RS17025	COG2814	Major facilitator Superfamily
SAM40697_RS17030	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS17035	COG1595	DNA-templated transcription, initiation
SAM40697_RS17085	COG0494	nUDIX hydrolase
SAM40697_RS17100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM40697_RS17115	COG0653	protein targeting
SAM40697_RS17135	COG0006	proline dipeptidase activity
SAM40697_RS17155	COG1999	signal sequence binding
SAM40697_RS17170	COG2837	iron assimilation
SAM40697_RS17175	COG0077	Prephenate dehydratase
SAM40697_RS17180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAM40697_RS17185	COG0561	phosphatase activity
SAM40697_RS17220	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SAM40697_RS17230	COG0561	phosphatase activity
SAM40697_RS17235	COG0739	heme binding
SAM40697_RS17245	COG4988	ABC transporter
SAM40697_RS17250	COG1294	oxidase, subunit
SAM40697_RS17255	COG1271	oxidase subunit
SAM40697_RS17265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAM40697_RS17270	COG1609	Transcriptional regulator
SAM40697_RS17275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAM40697_RS17290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SAM40697_RS17315	COG0662	Cupin 2, conserved barrel domain protein
SAM40697_RS17320	COG1950	PFAM Membrane protein of
SAM40697_RS17325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM40697_RS17330	COG0626	cystathionine gamma-synthase activity
SAM40697_RS17355	COG2814	Major facilitator Superfamily
SAM40697_RS17375	COG0305	Participates in initiation and elongation during chromosome replication
SAM40697_RS17385	COG0359	binds to the 23S rRNA
SAM40697_RS17390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAM40697_RS17395	COG0629	single-stranded DNA binding
SAM40697_RS17400	COG0360	Binds together with S18 to 16S ribosomal RNA
SAM40697_RS17425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM40697_RS17435	COG1260	myo-inositol-1-phosphate synthase
SAM40697_RS17450	COG0617	tRNA 3'-terminal CCA addition
SAM40697_RS17465	COG2815	serine threonine protein kinase
SAM40697_RS17465	COG0515	serine threonine protein kinase
SAM40697_RS17470	COG1595	DNA-templated transcription, initiation
SAM40697_RS17480	COG0492	ferredoxin-NADP+ reductase activity
SAM40697_RS17485	COG3118	belongs to the thioredoxin family
SAM40697_RS17500	COG1192	Involved in chromosome partitioning
SAM40697_RS17505	COG0357	Ribosomal RNA small subunit methyltransferase G
SAM40697_RS17515	COG0706	membrane insertase activity
SAM40697_RS17520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAM40697_RS17530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAM40697_RS17535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAM40697_RS17540	COG0592	DNA-directed DNA polymerase activity
SAM40697_RS17545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAM40697_RS17550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAM40697_RS17555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SAM40697_RS17560	COG0187	DNA topoisomerase II activity
SAM40697_RS17565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAM40697_RS17585	COG2319	Wd-40 repeat
SAM40697_RS17585	COG4249	Peptidase C14 caspase catalytic subunit p20
SAM40697_RS17615	COG0515	serine threonine protein kinase
SAM40697_RS17630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM40697_RS17645	COG0705	Rhomboid family
SAM40697_RS17665	COG3764	Sortase (surface protein transpeptidase)
SAM40697_RS17670	COG3764	Sortase (surface protein transpeptidase)
SAM40697_RS17675	COG0515	serine threonine protein kinase
SAM40697_RS17680	COG0768	penicillin binding
SAM40697_RS17695	COG1716	ATPase activity
SAM40697_RS17700	COG1716	ATPase activity
SAM40697_RS17750	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS17755	COG1309	transcriptional regulator
SAM40697_RS17760	COG1522	sequence-specific DNA binding
SAM40697_RS17805	COG3321	synthase
SAM40697_RS17805	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS17805	COG0604	alcohol dehydrogenase
SAM40697_RS17825	COG0515	serine threonine protein kinase
SAM40697_RS17830	COG0515	serine threonine protein kinase
SAM40697_RS17850	COG0022	dehydrogenase e1 component
SAM40697_RS17855	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM40697_RS17875	COG2186	Transcriptional regulator
SAM40697_RS17910	COG1362	aminopeptidase activity
SAM40697_RS17915	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS17925	COG1741	Belongs to the pirin family
SAM40697_RS17940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAM40697_RS17970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAM40697_RS18020	COG1653	transport
SAM40697_RS18045	COG0366	Alpha amylase catalytic
SAM40697_RS18050	COG1957	nucleoside hydrolase
SAM40697_RS18070	COG0583	DNA-binding transcription factor activity
SAM40697_RS18095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM40697_RS18125	COG1278	Cold shock
SAM40697_RS18155	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS18160	COG5002	protein histidine kinase activity
SAM40697_RS18165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAM40697_RS18200	COG0513	Belongs to the DEAD box helicase family
SAM40697_RS18205	COG1278	Cold shock
SAM40697_RS18240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM40697_RS18245	COG0667	Aldo Keto reductase
SAM40697_RS18255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS18285	COG2050	protein possibly involved in aromatic compounds catabolism
SAM40697_RS18290	COG0667	Aldo Keto reductase
SAM40697_RS18305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS18325	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SAM40697_RS18335	COG0717	Belongs to the dCTP deaminase family
SAM40697_RS18340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SAM40697_RS18355	COG2181	nitrate reductase activity
SAM40697_RS18355	COG0247	lactate metabolic process
SAM40697_RS18360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAM40697_RS18365	COG0443	Heat shock 70 kDa protein
SAM40697_RS18370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAM40697_RS18375	COG0484	heat shock protein binding
SAM40697_RS18380	COG0789	Transcriptional regulator
SAM40697_RS18385	COG4213	ABC transporter substrate-binding protein
SAM40697_RS18395	COG1136	(ABC) transporter
SAM40697_RS18435	COG0542	response to heat
SAM40697_RS18460	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM40697_RS18475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAM40697_RS18480	COG0191	fructose-bisphosphate aldolase activity
SAM40697_RS18485	COG0477	Major facilitator Superfamily
SAM40697_RS18500	COG3844	kynureninase activity
SAM40697_RS18525	COG4585	Histidine kinase
SAM40697_RS18530	COG2197	response regulator
SAM40697_RS18535	COG4585	Histidine kinase
SAM40697_RS18540	COG2197	response regulator
SAM40697_RS18545	COG2124	cytochrome p450
SAM40697_RS18550	COG3559	Exporter of polyketide antibiotics
SAM40697_RS18555	COG1131	(ABC) transporter
SAM40697_RS18570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAM40697_RS18585	COG1595	DNA-templated transcription, initiation
SAM40697_RS18600	COG1802	Transcriptional regulator
SAM40697_RS18610	COG0693	protein deglycase activity
SAM40697_RS18630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAM40697_RS18635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAM40697_RS18655	COG1595	DNA-templated transcription, initiation
SAM40697_RS18680	COG1585	Membrane protein implicated in regulation of membrane protease activity
SAM40697_RS18685	COG2268	Band 7 protein
SAM40697_RS18700	COG3655	Transcriptional regulator
SAM40697_RS18710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM40697_RS18725	COG1408	metallophosphoesterase
SAM40697_RS18730	COG1610	YqeY-like protein
SAM40697_RS18735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM40697_RS18745	COG0003	Pfam Anion-transporting ATPase
SAM40697_RS18760	COG0596	Alpha beta hydrolase
SAM40697_RS18770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAM40697_RS18795	COG2267	carboxylic ester hydrolase activity
SAM40697_RS18805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAM40697_RS18810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM40697_RS18865	COG1205	dead DEAH box helicase
SAM40697_RS18865	COG1111	helicase
SAM40697_RS18870	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS18875	COG2172	sigma factor antagonist activity
SAM40697_RS18880	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SAM40697_RS18900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAM40697_RS18900	COG1754	DNA topoisomerase type I activity
SAM40697_RS18905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAM40697_RS18935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM40697_RS18935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAM40697_RS18945	COG1280	lysine exporter protein (LysE YggA)
SAM40697_RS18970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAM40697_RS18975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAM40697_RS18980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM40697_RS18985	COG0254	rRNA binding
SAM40697_RS18995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAM40697_RS19015	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS19020	COG2318	DinB family
SAM40697_RS19040	COG0076	glutamate decarboxylase activity
SAM40697_RS19045	COG0789	Transcriptional regulator
SAM40697_RS19050	COG0393	Putative heavy-metal-binding
SAM40697_RS19065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SAM40697_RS19070	COG2027	D-alanyl-D-alanine carboxypeptidase
SAM40697_RS19080	COG0037	tRNA processing
SAM40697_RS19095	COG0302	gtp cyclohydrolase
SAM40697_RS19105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SAM40697_RS19110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SAM40697_RS19150	COG0649	NAD binding
SAM40697_RS19165	COG2197	response regulator
SAM40697_RS19170	COG0640	Transcriptional regulator
SAM40697_RS19190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SAM40697_RS19195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAM40697_RS19205	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SAM40697_RS19225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAM40697_RS19255	COG0739	heme binding
SAM40697_RS19270	COG2205	protein histidine kinase activity
SAM40697_RS19275	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS19285	COG1595	DNA-templated transcription, initiation
SAM40697_RS19290	COG1194	a g-specific adenine glycosylase
SAM40697_RS19295	COG4585	Histidine kinase
SAM40697_RS19305	COG0671	phosphoesterase, PA-phosphatase related
SAM40697_RS19315	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SAM40697_RS19335	COG0248	Ppx GppA phosphatase
SAM40697_RS19340	COG1082	Xylose isomerase domain protein TIM barrel
SAM40697_RS19345	COG1309	transcriptional regulator
SAM40697_RS19350	COG0129	dihydroxy-acid dehydratase activity
SAM40697_RS19355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAM40697_RS19355	COG0515	serine threonine protein kinase
SAM40697_RS19375	COG0842	Transport permease protein
SAM40697_RS19375	COG1129	ABC transporter
SAM40697_RS19385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAM40697_RS19390	COG0180	Tryptophanyl-tRNA synthetase
SAM40697_RS19410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM40697_RS19420	COG2223	nitrite transmembrane transporter activity
SAM40697_RS19425	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAM40697_RS19470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAM40697_RS19475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SAM40697_RS19480	COG0181	hydroxymethylbilane synthase activity
SAM40697_RS19485	COG1648	precorrin-2 dehydrogenase activity
SAM40697_RS19485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAM40697_RS19500	COG0113	porphobilinogen synthase activity
SAM40697_RS19515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM40697_RS19530	COG0018	arginyl-trna synthetase
SAM40697_RS19535	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SAM40697_RS19555	COG1690	Belongs to the RtcB family
SAM40697_RS19565	COG1742	UPF0060 membrane protein
SAM40697_RS19575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS19580	COG0431	NADPH-dependent FMN reductase
SAM40697_RS19585	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS19590	COG2205	protein histidine kinase activity
SAM40697_RS19635	COG0513	Belongs to the DEAD box helicase family
SAM40697_RS19640	COG1278	Cold shock
SAM40697_RS19670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAM40697_RS19695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SAM40697_RS19710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAM40697_RS19715	COG0406	alpha-ribazole phosphatase activity
SAM40697_RS19725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAM40697_RS19730	COG0785	Cytochrome C biogenesis protein
SAM40697_RS19735	COG1333	cytochrome c biogenesis protein
SAM40697_RS19740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAM40697_RS19790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SAM40697_RS19795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SAM40697_RS19800	COG0163	prenyltransferase activity
SAM40697_RS19810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM40697_RS19815	COG1573	uracil-dna glycosylase
SAM40697_RS19830	COG1301	dicarboxylic acid transport
SAM40697_RS19835	COG1309	transcriptional regulator
SAM40697_RS19850	COG0183	Belongs to the thiolase family
SAM40697_RS19860	COG2226	methyltransferase
SAM40697_RS19875	COG1396	sequence-specific DNA binding
SAM40697_RS19880	COG1278	Cold shock
SAM40697_RS19885	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAM40697_RS19895	COG1674	ftsk spoiiie
SAM40697_RS19915	COG4842	Belongs to the WXG100 family
SAM40697_RS20040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SAM40697_RS20095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAM40697_RS20110	COG2226	methyltransferase
SAM40697_RS20125	COG0242	peptide deformylase activity
SAM40697_RS20140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20150	COG0649	NAD binding
SAM40697_RS20160	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAM40697_RS20165	COG1034	ATP synthesis coupled electron transport
SAM40697_RS20170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAM40697_RS20175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20180	COG0839	Belongs to the complex I subunit 6 family
SAM40697_RS20185	COG0713	ATP synthesis coupled electron transport
SAM40697_RS20190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM40697_RS20200	COG1007	ATP synthesis coupled electron transport
SAM40697_RS20210	COG0514	ATP-dependent DNA helicase (RecQ)
SAM40697_RS20220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAM40697_RS20240	COG2188	Transcriptional regulator
SAM40697_RS20255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM40697_RS20280	COG0726	polysaccharide deacetylase
SAM40697_RS20295	COG0561	phosphatase activity
SAM40697_RS20305	COG0142	geranyltranstransferase activity
SAM40697_RS20315	COG1131	(ABC) transporter
SAM40697_RS20325	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAM40697_RS20355	COG0702	epimerase
SAM40697_RS20360	COG1013	pyruvate-flavodoxin oxidoreductase activity
SAM40697_RS20365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SAM40697_RS20365	COG0674	pyruvate-flavodoxin oxidoreductase activity
SAM40697_RS20385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAM40697_RS20405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAM40697_RS20415	COG0713	ATP synthesis coupled electron transport
SAM40697_RS20420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM40697_RS20430	COG1007	ATP synthesis coupled electron transport
SAM40697_RS20435	COG0501	Belongs to the peptidase M48B family
SAM40697_RS20440	COG3304	Inner membrane component domain
SAM40697_RS20455	COG2261	transglycosylase associated protein
SAM40697_RS20460	COG1666	GTP binding
SAM40697_RS20470	COG0702	epimerase
SAM40697_RS20475	COG0402	S-adenosylhomocysteine deaminase activity
SAM40697_RS20490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM40697_RS20495	COG2030	dehydratase
SAM40697_RS20510	COG0477	Major facilitator Superfamily
SAM40697_RS20520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAM40697_RS20530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM40697_RS20535	COG0436	Aminotransferase
SAM40697_RS20545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAM40697_RS20550	COG0250	Participates in transcription elongation, termination and antitermination
SAM40697_RS20555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAM40697_RS20560	COG0081	regulation of translation
SAM40697_RS20575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAM40697_RS20580	COG0222	ribosome binding
SAM40697_RS20585	COG0085	RNA polymerase activity
SAM40697_RS20590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAM40697_RS20600	COG0463	Glycosyl transferase, family 2
SAM40697_RS20605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAM40697_RS20610	COG0049	tRNA binding
SAM40697_RS20615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAM40697_RS20620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAM40697_RS20630	COG0577	efflux transmembrane transporter activity
SAM40697_RS20635	COG1136	(ABC) transporter
SAM40697_RS20645	COG2197	response regulator
SAM40697_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS20690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAM40697_RS20695	COG0051	transcription antitermination factor activity, RNA binding
SAM40697_RS20700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAM40697_RS20705	COG0088	Forms part of the polypeptide exit tunnel
SAM40697_RS20710	COG0089	rRNA binding
SAM40697_RS20715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAM40697_RS20720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAM40697_RS20725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAM40697_RS20730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAM40697_RS20735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAM40697_RS20740	COG0255	Belongs to the universal ribosomal protein uL29 family
SAM40697_RS20745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAM40697_RS20750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAM40697_RS20755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAM40697_RS20760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAM40697_RS20765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAM40697_RS20770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAM40697_RS20775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAM40697_RS20780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAM40697_RS20785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAM40697_RS20790	COG1841	ribosomal large subunit assembly
SAM40697_RS20795	COG0200	Binds to the 23S rRNA
SAM40697_RS20800	COG0201	protein transport
SAM40697_RS20805	COG0563	adenylate kinase activity
SAM40697_RS20815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAM40697_RS20820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAM40697_RS20825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAM40697_RS20830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAM40697_RS20835	COG0202	RNA polymerase activity
SAM40697_RS20840	COG0203	ribosomal protein L17
SAM40697_RS20845	COG0101	tRNA pseudouridine synthase activity
SAM40697_RS20860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAM40697_RS20865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAM40697_RS20870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM40697_RS20875	COG1072	(Pantothenic acid kinase))
SAM40697_RS20885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAM40697_RS20905	COG0736	holo-[acyl-carrier-protein] synthase activity
SAM40697_RS20910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAM40697_RS20920	COG0802	atpase or kinase
SAM40697_RS20930	COG0456	acetyltransferase
SAM40697_RS20930	COG1214	PFAM Peptidase M22, glycoprotease
SAM40697_RS20940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAM40697_RS20955	COG1316	TRANSCRIPTIONal
SAM40697_RS20965	COG4941	Belongs to the sigma-70 factor family
SAM40697_RS20975	COG0726	polysaccharide deacetylase
SAM40697_RS20980	COG0726	polysaccharide deacetylase
SAM40697_RS20985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAM40697_RS20990	COG0459	protein refolding
SAM40697_RS21000	COG4221	oxidoreductase activity
SAM40697_RS21010	COG0583	DNA-binding transcription factor activity
SAM40697_RS21025	COG1595	DNA-templated transcription, initiation
SAM40697_RS21035	COG0516	GMP reductase activity
SAM40697_RS21045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAM40697_RS21055	COG0515	serine threonine protein kinase
SAM40697_RS21055	COG2815	serine threonine protein kinase
SAM40697_RS21060	COG0515	serine threonine protein kinase
SAM40697_RS21070	COG0515	serine threonine protein kinase
SAM40697_RS21075	COG0515	serine threonine protein kinase
SAM40697_RS21080	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS21100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAM40697_RS21100	COG0519	Catalyzes the synthesis of GMP from XMP
SAM40697_RS21145	COG2197	response regulator
SAM40697_RS21150	COG0791	NLP P60 protein
SAM40697_RS21175	COG0739	heme binding
SAM40697_RS21185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS21185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS21200	COG0714	Associated with various cellular activities
SAM40697_RS21205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SAM40697_RS21210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAM40697_RS21225	COG0045	succinate-CoA ligase (ADP-forming) activity
SAM40697_RS21255	COG0138	bifunctional purine biosynthesis protein purh
SAM40697_RS21265	COG0515	serine threonine protein kinase
SAM40697_RS21280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAM40697_RS21295	COG0039	L-malate dehydrogenase activity
SAM40697_RS21315	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS21325	COG0517	IMP dehydrogenase activity
SAM40697_RS21325	COG4175	Glycine betaine
SAM40697_RS21345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS21350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAM40697_RS21360	COG0754	glutathionylspermidine amidase activity
SAM40697_RS21365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM40697_RS21370	COG0180	Tryptophanyl-tRNA synthetase
SAM40697_RS21390	COG0671	phosphoesterase, PA-phosphatase related
SAM40697_RS21405	COG1295	ribonuclease BN
SAM40697_RS21410	COG1686	Belongs to the peptidase S11 family
SAM40697_RS21420	COG1408	metallophosphoesterase
SAM40697_RS21425	COG1309	transcriptional regulator
SAM40697_RS21465	COG1053	succinate dehydrogenase
SAM40697_RS21475	COG2009	succinate dehydrogenase
SAM40697_RS21505	COG1595	DNA-templated transcription, initiation
SAM40697_RS21515	COG1595	DNA-templated transcription, initiation
SAM40697_RS21530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS21530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS21570	COG1216	Glycosyl transferase, family 2
SAM40697_RS21590	COG1216	Glycosyl transferase, family 2
SAM40697_RS21605	COG2089	acid synthase
SAM40697_RS21620	COG1473	amidohydrolase
SAM40697_RS21620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAM40697_RS21625	COG1744	ABC transporter substrate-binding protein PnrA-like
SAM40697_RS21630	COG1744	ABC transporter substrate-binding protein PnrA-like
SAM40697_RS21635	COG3845	ABC transporter
SAM40697_RS21645	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAM40697_RS21660	COG3344	reverse transcriptase
SAM40697_RS21680	COG2814	Major facilitator Superfamily
SAM40697_RS21685	COG0583	DNA-binding transcription factor activity
SAM40697_RS21695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM40697_RS21720	COG2205	protein histidine kinase activity
SAM40697_RS21725	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS21730	COG1595	DNA-templated transcription, initiation
SAM40697_RS21745	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS21750	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS21770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAM40697_RS21795	COG4770	biotin carboxylase activity
SAM40697_RS21805	COG0424	maF-like protein
SAM40697_RS21815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS21825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAM40697_RS21835	COG1024	Enoyl-CoA hydratase
SAM40697_RS21845	COG2986	histidine ammonia-lyase
SAM40697_RS21865	COG1404	Belongs to the peptidase S8 family
SAM40697_RS21900	COG1064	alcohol dehydrogenase
SAM40697_RS21905	COG1090	epimerase
SAM40697_RS21925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAM40697_RS21950	COG2255	four-way junction helicase activity
SAM40697_RS21955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAM40697_RS21970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAM40697_RS21980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM40697_RS21995	COG1331	Highly conserved protein containing a thioredoxin domain
SAM40697_RS22025	COG1309	transcriptional regulator
SAM40697_RS22035	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SAM40697_RS22050	COG0436	Aminotransferase
SAM40697_RS22055	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SAM40697_RS22070	COG1414	Transcriptional regulator
SAM40697_RS22075	COG0251	oxidation-reduction process
SAM40697_RS22080	COG2610	gluconate transmembrane transporter activity
SAM40697_RS22125	COG2894	cell division
SAM40697_RS22205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SAM40697_RS22210	COG0741	lytic transglycosylase activity
SAM40697_RS22220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS22225	COG0450	alkyl hydroperoxide reductase
SAM40697_RS22240	COG1136	(ABC) transporter
SAM40697_RS22260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAM40697_RS22275	COG0114	fumarate hydratase activity
SAM40697_RS22280	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SAM40697_RS22280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SAM40697_RS22305	COG0778	Nitroreductase
SAM40697_RS22330	COG1722	exodeoxyribonuclease VII activity
SAM40697_RS22335	COG1570	exodeoxyribonuclease VII activity
SAM40697_RS22345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SAM40697_RS22360	COG0012	GTP binding
SAM40697_RS22375	COG2197	response regulator
SAM40697_RS22380	COG4585	Histidine kinase
SAM40697_RS22385	COG2409	Drug exporters of the RND superfamily
SAM40697_RS22390	COG3833	ABC-type maltose transport systems, permease component
SAM40697_RS22395	COG1175	transmembrane transport
SAM40697_RS22405	COG3250	beta-galactosidase activity
SAM40697_RS22410	COG1609	Transcriptional regulator
SAM40697_RS22425	COG0583	DNA-binding transcription factor activity
SAM40697_RS22475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAM40697_RS22480	COG1053	succinate dehydrogenase
SAM40697_RS22500	COG1217	gtp-binding protein TYPA
SAM40697_RS22505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS22510	COG4166	transmembrane transport
SAM40697_RS22515	COG0601	transmembrane transport
SAM40697_RS22520	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS22525	COG4608	Belongs to the ABC transporter superfamily
SAM40697_RS22530	COG4608	Belongs to the ABC transporter superfamily
SAM40697_RS22535	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS22545	COG0747	negative chemotaxis
SAM40697_RS22550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS22560	COG0601	transmembrane transport
SAM40697_RS22565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS22570	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS22575	COG4608	Belongs to the ABC transporter superfamily
SAM40697_RS22590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAM40697_RS22635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAM40697_RS22645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SAM40697_RS22655	COG2818	Glycosylase
SAM40697_RS22660	COG1024	Enoyl-CoA hydratase
SAM40697_RS22670	COG1595	DNA-templated transcription, initiation
SAM40697_RS22680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAM40697_RS22685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAM40697_RS22710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAM40697_RS22720	COG0598	Magnesium transport protein CorA
SAM40697_RS22730	COG2814	Major facilitator Superfamily
SAM40697_RS22745	COG2095	MarC family integral membrane protein
SAM40697_RS22750	COG1432	Conserved Protein
SAM40697_RS22825	COG0596	Alpha beta hydrolase
SAM40697_RS22850	COG0210	DNA helicase
SAM40697_RS22860	COG2816	NAD+ diphosphatase activity
SAM40697_RS22885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAM40697_RS22935	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAM40697_RS22945	COG1615	UPF0182 protein
SAM40697_RS22970	COG0753	catalase activity
SAM40697_RS22980	COG0483	inositol monophosphate 1-phosphatase activity
SAM40697_RS23000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAM40697_RS23010	COG2135	peptidase activity
SAM40697_RS23020	COG1595	DNA-templated transcription, initiation
SAM40697_RS23025	COG5662	AntiSigma factor
SAM40697_RS23045	COG0242	peptide deformylase activity
SAM40697_RS23055	COG2124	cytochrome p450
SAM40697_RS23095	COG2188	Transcriptional regulator
SAM40697_RS23100	COG2182	Extracellular solute-binding protein
SAM40697_RS23105	COG1175	transmembrane transport
SAM40697_RS23110	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS23115	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM40697_RS23120	COG0363	glucosamine-6-phosphate deaminase activity
SAM40697_RS23125	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS23145	COG1597	lipid kinase activity
SAM40697_RS23155	COG1191	sigma factor activity
SAM40697_RS23185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAM40697_RS23190	COG0142	geranyltranstransferase activity
SAM40697_RS23215	COG4106	trans-aconitate 2-methyltransferase activity
SAM40697_RS23220	COG1126	abc transporter atp-binding protein
SAM40697_RS23235	COG0281	malic enzyme
SAM40697_RS23240	COG0604	alcohol dehydrogenase
SAM40697_RS23275	COG0567	Dehydrogenase, E1 component
SAM40697_RS23275	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAM40697_RS23280	COG2205	protein histidine kinase activity
SAM40697_RS23285	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS23295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAM40697_RS23340	COG3883	PFAM NLP P60 protein
SAM40697_RS23340	COG0791	NLP P60 protein
SAM40697_RS23350	COG1309	transcriptional regulator
SAM40697_RS23380	COG2205	protein histidine kinase activity
SAM40697_RS23395	COG3285	dna ligase
SAM40697_RS23395	COG1793	dna ligase
SAM40697_RS23400	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM40697_RS23415	COG3467	pyridoxamine 5'-phosphate
SAM40697_RS23425	COG2867	negative regulation of translational initiation
SAM40697_RS23430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM40697_RS23435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS23440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS23445	COG0662	Cupin 2, conserved barrel domain protein
SAM40697_RS23450	COG2329	Antibiotic biosynthesis monooxygenase
SAM40697_RS23455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS23545	COG0018	arginyl-trna synthetase
SAM40697_RS23550	COG0019	diaminopimelate decarboxylase activity
SAM40697_RS23555	COG0460	homoserine dehydrogenase
SAM40697_RS23560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAM40697_RS23565	COG0083	homoserine kinase activity
SAM40697_RS23585	COG0254	rRNA binding
SAM40697_RS23590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAM40697_RS23595	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM40697_RS23605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM40697_RS23610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM40697_RS23630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAM40697_RS23635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAM40697_RS23640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAM40697_RS23645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAM40697_RS23650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAM40697_RS23655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAM40697_RS23660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAM40697_RS23675	COG2197	response regulator
SAM40697_RS23680	COG4585	Histidine kinase
SAM40697_RS23715	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS23730	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SAM40697_RS23765	COG1131	(ABC) transporter
SAM40697_RS23785	COG0183	Belongs to the thiolase family
SAM40697_RS23805	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS23810	COG2205	protein histidine kinase activity
SAM40697_RS23855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS23855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS23890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAM40697_RS23895	COG0280	phosphate acetyltransferase
SAM40697_RS23895	COG0857	belongs to the CobB CobQ family
SAM40697_RS23900	COG0205	6-phosphofructokinase activity
SAM40697_RS23910	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS23925	COG4565	transcriptional regulatory protein
SAM40697_RS23930	COG4191	Histidine kinase
SAM40697_RS23935	COG1301	dicarboxylic acid transport
SAM40697_RS23960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAM40697_RS23965	COG3281	Trehalose synthase
SAM40697_RS23970	COG0366	Alpha amylase catalytic
SAM40697_RS23975	COG0366	Alpha amylase catalytic
SAM40697_RS23980	COG0058	SHG alpha-glucan phosphorylase activity
SAM40697_RS24000	COG1132	(ABC) transporter
SAM40697_RS24005	COG1132	(ABC) transporter
SAM40697_RS24010	COG1132	(ABC) transporter
SAM40697_RS24015	COG1132	(ABC) transporter
SAM40697_RS24020	COG3119	arylsulfatase activity
SAM40697_RS24035	COG1376	ErfK ybiS ycfS ynhG family protein
SAM40697_RS24065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM40697_RS24070	COG3409	Peptidoglycan-binding domain 1 protein
SAM40697_RS24070	COG3757	hydrolase, family 25
SAM40697_RS24075	COG0477	Major facilitator Superfamily
SAM40697_RS24080	COG1760	l-serine dehydratase
SAM40697_RS24085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAM40697_RS24090	COG0509	glycine decarboxylation via glycine cleavage system
SAM40697_RS24095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAM40697_RS24115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS24130	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS24135	COG4608	Belongs to the ABC transporter superfamily
SAM40697_RS24140	COG2860	membrane
SAM40697_RS24150	COG0789	Transcriptional regulator
SAM40697_RS24180	COG0482	sulfurtransferase activity
SAM40697_RS24195	COG1611	Belongs to the LOG family
SAM40697_RS24200	COG4221	oxidoreductase activity
SAM40697_RS24210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAM40697_RS24220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAM40697_RS24225	COG0154	amidase activity
SAM40697_RS24235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAM40697_RS24240	COG2409	Drug exporters of the RND superfamily
SAM40697_RS24245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM40697_RS24260	COG2197	response regulator
SAM40697_RS24270	COG2133	pyrroloquinoline quinone binding
SAM40697_RS24275	COG0667	Aldo Keto reductase
SAM40697_RS24285	COG5001	Diguanylate cyclase
SAM40697_RS24295	COG0440	acetolactate synthase activity
SAM40697_RS24300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAM40697_RS24305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAM40697_RS24310	COG0477	Major facilitator Superfamily
SAM40697_RS24325	COG0506	proline dehydrogenase activity
SAM40697_RS24330	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS24340	COG0473	3-isopropylmalate dehydrogenase activity
SAM40697_RS24345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAM40697_RS24355	COG0832	Belongs to the urease beta subunit family
SAM40697_RS24355	COG0831	urea catabolic process
SAM40697_RS24360	COG0804	urea catabolic process
SAM40697_RS24365	COG2957	Belongs to the agmatine deiminase family
SAM40697_RS24375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAM40697_RS24400	COG2353	YceI-like domain
SAM40697_RS24405	COG5492	domain, Protein
SAM40697_RS24410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS24430	COG2018	Roadblock/LC7 domain
SAM40697_RS24450	COG2018	Roadblock/LC7 domain
SAM40697_RS24455	COG5002	protein histidine kinase activity
SAM40697_RS24460	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAM40697_RS24465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAM40697_RS24500	COG1414	Transcriptional regulator
SAM40697_RS24505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAM40697_RS24510	COG0066	3-isopropylmalate dehydratase activity
SAM40697_RS24520	COG0776	regulation of translation
SAM40697_RS24530	COG1920	GTP binding
SAM40697_RS24540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAM40697_RS24545	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAM40697_RS24560	COG0351	phosphomethylpyrimidine kinase
SAM40697_RS24570	COG1461	Dihydroxyacetone kinase
SAM40697_RS24580	COG0742	ribosomal rna small subunit methyltransferase
SAM40697_RS24585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAM40697_RS24600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAM40697_RS24605	COG0571	ribonuclease III activity
SAM40697_RS24610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM40697_RS24615	COG1733	regulation of RNA biosynthetic process
SAM40697_RS24625	COG2340	Cysteine-rich secretory protein family
SAM40697_RS24630	COG1254	Belongs to the acylphosphatase family
SAM40697_RS24645	COG0477	Major facilitator Superfamily
SAM40697_RS24680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SAM40697_RS24690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAM40697_RS24710	COG0228	four-way junction DNA binding
SAM40697_RS24715	COG1837	Belongs to the UPF0109 family
SAM40697_RS24720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAM40697_RS24725	COG0336	Belongs to the RNA methyltransferase TrmD family
SAM40697_RS24730	COG0335	large ribosomal subunit rRNA binding
SAM40697_RS24745	COG0681	Belongs to the peptidase S26 family
SAM40697_RS24750	COG0681	Belongs to the peptidase S26 family
SAM40697_RS24755	COG1051	belongs to the nudix hydrolase family
SAM40697_RS24765	COG0792	nuclease activity
SAM40697_RS24780	COG1191	sigma factor activity
SAM40697_RS24795	COG0052	Belongs to the universal ribosomal protein uS2 family
SAM40697_RS24800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAM40697_RS24805	COG0528	UMP kinase activity
SAM40697_RS24810	COG0233	cytoplasmic translational termination
SAM40697_RS24815	COG0575	Belongs to the CDS family
SAM40697_RS24820	COG1247	-acetyltransferase
SAM40697_RS24825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM40697_RS24830	COG0798	PFAM Bile acid sodium symporter
SAM40697_RS24835	COG0640	Transcriptional regulator
SAM40697_RS24845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAM40697_RS24855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SAM40697_RS24860	COG3842	ATPase activity
SAM40697_RS24895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAM40697_RS24905	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS24920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAM40697_RS24945	COG3842	ATPase activity
SAM40697_RS24950	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAM40697_RS24955	COG1177	transmembrane transport
SAM40697_RS24960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM40697_RS24990	COG2508	Transcriptional regulator
SAM40697_RS24995	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS25000	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS25015	COG4209	transmembrane transport
SAM40697_RS25020	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS25050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SAM40697_RS25055	COG0750	zinc metalloprotease
SAM40697_RS25060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAM40697_RS25075	COG0442	prolyl-tRNA aminoacylation
SAM40697_RS25095	COG0779	Required for maturation of 30S ribosomal subunits
SAM40697_RS25105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAM40697_RS25115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAM40697_RS25120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAM40697_RS25135	COG0455	bacterial-type flagellum organization
SAM40697_RS25150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAM40697_RS25155	COG1185	polyribonucleotide nucleotidyltransferase activity
SAM40697_RS25160	COG0612	Peptidase, M16
SAM40697_RS25165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAM40697_RS25185	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SAM40697_RS25190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAM40697_RS25195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAM40697_RS25225	COG2208	phosphoserine phosphatase activity
SAM40697_RS25225	COG2770	Histidine kinase
SAM40697_RS25230	COG2205	protein histidine kinase activity
SAM40697_RS25230	COG0784	Response regulator, receiver
SAM40697_RS25240	COG1674	ftsk spoiiie
SAM40697_RS25250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAM40697_RS25260	COG1058	Belongs to the CinA family
SAM40697_RS25260	COG1546	Belongs to the CinA family
SAM40697_RS25265	COG1396	sequence-specific DNA binding
SAM40697_RS25270	COG0783	Belongs to the Dps family
SAM40697_RS25280	COG0640	Transcriptional regulator
SAM40697_RS25290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM40697_RS25295	COG1201	RNA secondary structure unwinding
SAM40697_RS25300	COG2207	Transcriptional regulator
SAM40697_RS25300	COG1917	Cupin 2, conserved barrel domain protein
SAM40697_RS25325	COG0628	permease
SAM40697_RS25360	COG0765	amino acid transport
SAM40697_RS25365	COG0765	amino acid transport
SAM40697_RS25370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM40697_RS25375	COG1126	abc transporter atp-binding protein
SAM40697_RS25380	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS25385	COG2205	protein histidine kinase activity
SAM40697_RS25415	COG2197	response regulator
SAM40697_RS25420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAM40697_RS25440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAM40697_RS25450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAM40697_RS25455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAM40697_RS25465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAM40697_RS25500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAM40697_RS25505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAM40697_RS25510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAM40697_RS25525	COG0588	phosphoglycerate mutase activity
SAM40697_RS25545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAM40697_RS25580	COG3842	ATPase activity
SAM40697_RS25585	COG2186	Transcriptional regulator
SAM40697_RS25590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM40697_RS25605	COG0187	DNA topoisomerase II activity
SAM40697_RS25615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAM40697_RS25620	COG4565	transcriptional regulatory protein
SAM40697_RS25625	COG3290	protein histidine kinase activity
SAM40697_RS25650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAM40697_RS25655	COG0612	Peptidase, M16
SAM40697_RS25670	COG1802	Transcriptional regulator
SAM40697_RS25675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAM40697_RS25695	COG1435	thymidine kinase activity
SAM40697_RS25730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAM40697_RS25740	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS25745	COG2205	protein histidine kinase activity
SAM40697_RS25770	COG0756	dUTP diphosphatase activity
SAM40697_RS25805	COG0569	domain protein
SAM40697_RS25810	COG0531	amino acid
SAM40697_RS25815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAM40697_RS25870	COG3654	unkown
SAM40697_RS25920	COG3693	PFAM glycoside hydrolase, family 10
SAM40697_RS25935	COG0667	Aldo Keto reductase
SAM40697_RS25945	COG4124	Belongs to the glycosyl hydrolase 26 family
SAM40697_RS25955	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS25960	COG1309	transcriptional regulator
SAM40697_RS25980	COG1819	glycosyl
SAM40697_RS25985	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS26010	COG0667	Aldo Keto reductase
SAM40697_RS26025	COG1819	glycosyl
SAM40697_RS26030	COG2124	cytochrome p450
SAM40697_RS26045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAM40697_RS26055	COG0488	(ABC) transporter
SAM40697_RS26090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM40697_RS26100	COG2124	cytochrome p450
SAM40697_RS26140	COG2226	methyltransferase
SAM40697_RS26150	COG1819	glycosyl
SAM40697_RS26170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAM40697_RS26190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAM40697_RS26275	COG2197	response regulator
SAM40697_RS26280	COG4585	Histidine kinase
SAM40697_RS26285	COG0531	amino acid
SAM40697_RS26295	COG0477	Major facilitator Superfamily
SAM40697_RS26300	COG1122	ATPase activity
SAM40697_RS26310	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SAM40697_RS26315	COG0310	cobalt ion transport
SAM40697_RS26320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SAM40697_RS26335	COG1799	cell septum assembly
SAM40697_RS26365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAM40697_RS26375	COG2255	four-way junction helicase activity
SAM40697_RS26385	COG0475	glutathione-regulated potassium exporter activity
SAM40697_RS26415	COG2235	arginine
SAM40697_RS26420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAM40697_RS26425	COG0531	amino acid
SAM40697_RS26435	COG1024	Enoyl-CoA hydratase
SAM40697_RS26455	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS26485	COG0659	secondary active sulfate transmembrane transporter activity
SAM40697_RS26510	COG2319	Wd-40 repeat
SAM40697_RS26530	COG0586	Pfam SNARE associated Golgi protein
SAM40697_RS26535	COG4585	Histidine kinase
SAM40697_RS26565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAM40697_RS26570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAM40697_RS26585	COG1653	transport
SAM40697_RS26590	COG1175	transmembrane transport
SAM40697_RS26595	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS26600	COG1940	carbohydrate kinase activity
SAM40697_RS26605	COG4213	ABC transporter substrate-binding protein
SAM40697_RS26615	COG4214	carbohydrate transport
SAM40697_RS26620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAM40697_RS26625	COG0531	amino acid
SAM40697_RS26645	COG1316	TRANSCRIPTIONal
SAM40697_RS26650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAM40697_RS26675	COG1024	Enoyl-CoA hydratase
SAM40697_RS26675	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS26680	COG0183	Belongs to the thiolase family
SAM40697_RS26685	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SAM40697_RS26700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SAM40697_RS26775	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAM40697_RS26785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAM40697_RS26790	COG3253	May function as heme-dependent peroxidase
SAM40697_RS26805	COG3220	belongs to the UPF0276 family
SAM40697_RS26830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAM40697_RS26830	COG0723	plastoquinol--plastocyanin reductase activity
SAM40697_RS26840	COG0330	HflC and HflK could
SAM40697_RS26875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAM40697_RS26880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAM40697_RS26885	COG2205	protein histidine kinase activity
SAM40697_RS26890	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS26900	COG1174	glycine betaine transport
SAM40697_RS26905	COG1174	glycine betaine transport
SAM40697_RS26940	COG1309	transcriptional regulator
SAM40697_RS26965	COG3173	Aminoglycoside phosphotransferase
SAM40697_RS26990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAM40697_RS26995	COG0583	DNA-binding transcription factor activity
SAM40697_RS27030	COG1175	transmembrane transport
SAM40697_RS27045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAM40697_RS27075	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAM40697_RS27095	COG0529	Catalyzes the synthesis of activated sulfate
SAM40697_RS27100	COG0175	sulfate reduction
SAM40697_RS27130	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS27155	COG1917	Cupin 2, conserved barrel domain protein
SAM40697_RS27155	COG4977	sequence-specific DNA binding
SAM40697_RS27190	COG1131	(ABC) transporter
SAM40697_RS27250	COG0714	Associated with various cellular activities
SAM40697_RS27265	COG2040	homocysteine
SAM40697_RS27310	COG0277	FAD linked oxidase domain protein
SAM40697_RS27325	COG1162	GTPase activity
SAM40697_RS27335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAM40697_RS27355	COG0028	Belongs to the TPP enzyme family
SAM40697_RS27375	COG1802	Transcriptional regulator
SAM40697_RS27380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM40697_RS27380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAM40697_RS27390	COG2197	response regulator
SAM40697_RS27395	COG3851	Histidine kinase
SAM40697_RS27425	COG3835	regulator
SAM40697_RS27440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM40697_RS27445	COG2252	PERMEase
SAM40697_RS27465	COG0726	polysaccharide deacetylase
SAM40697_RS27470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM40697_RS27475	COG2192	nodulation
SAM40697_RS27485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SAM40697_RS27490	COG0859	PFAM glycosyl transferase family 9
SAM40697_RS27495	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS27500	COG0297	glycogen (starch) synthase activity
SAM40697_RS27505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SAM40697_RS27510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAM40697_RS27510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAM40697_RS27515	COG0859	PFAM glycosyl transferase family 9
SAM40697_RS27565	COG2197	response regulator
SAM40697_RS27570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAM40697_RS27575	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS27610	COG3960	tartronate-semialdehyde synthase activity
SAM40697_RS27625	COG0753	catalase activity
SAM40697_RS27630	COG2084	Dehydrogenase
SAM40697_RS27635	COG3622	Belongs to the hyi family
SAM40697_RS27655	COG2351	hydroxyisourate hydrolase activity
SAM40697_RS27665	COG2233	PERMEase
SAM40697_RS27685	COG1733	regulation of RNA biosynthetic process
SAM40697_RS27700	COG0406	alpha-ribazole phosphatase activity
SAM40697_RS27705	COG0436	Aminotransferase
SAM40697_RS27725	COG4264	IucA IucC family
SAM40697_RS27740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAM40697_RS27755	COG1414	Transcriptional regulator
SAM40697_RS27760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM40697_RS27765	COG4266	Belongs to the allantoicase family
SAM40697_RS27770	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS27790	COG2197	response regulator
SAM40697_RS27800	COG2188	Transcriptional regulator
SAM40697_RS27820	COG1940	carbohydrate kinase activity
SAM40697_RS27830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM40697_RS27870	COG4948	Mandelate Racemase Muconate Lactonizing
SAM40697_RS27880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SAM40697_RS27885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS27890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAM40697_RS27895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAM40697_RS27905	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAM40697_RS27910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAM40697_RS27940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SAM40697_RS27965	COG0640	Transcriptional regulator
SAM40697_RS27970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS27975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAM40697_RS27995	COG0405	Gamma-glutamyltransferase
SAM40697_RS28000	COG0542	response to heat
SAM40697_RS28020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAM40697_RS28035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAM40697_RS28040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS28045	COG1953	Uracil, thiamine, allantoin
SAM40697_RS28055	COG2226	methyltransferase
SAM40697_RS28070	COG2197	response regulator
SAM40697_RS28095	COG0483	inositol monophosphate 1-phosphatase activity
SAM40697_RS28105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SAM40697_RS28115	COG0601	transmembrane transport
SAM40697_RS28120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS28125	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS28130	COG0444	Belongs to the ABC transporter superfamily
SAM40697_RS28150	COG0640	Transcriptional regulator
SAM40697_RS28155	COG2217	Heavy metal translocating P-type atpase
SAM40697_RS28165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAM40697_RS28175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAM40697_RS28185	COG1929	Belongs to the glycerate kinase type-1 family
SAM40697_RS28195	COG0688	phosphatidylethanolamine metabolic process
SAM40697_RS28200	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS28210	COG2301	Belongs to the HpcH HpaI aldolase family
SAM40697_RS28215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS28215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAM40697_RS28230	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS28275	COG2362	D-Aminopeptidase
SAM40697_RS28280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAM40697_RS28290	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAM40697_RS28320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS28330	COG3959	Transketolase, thiamine diphosphate binding domain
SAM40697_RS28400	COG1597	lipid kinase activity
SAM40697_RS28420	COG0693	protein deglycase activity
SAM40697_RS28425	COG0517	IMP dehydrogenase activity
SAM40697_RS28435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM40697_RS28450	COG0028	Belongs to the TPP enzyme family
SAM40697_RS28495	COG0531	amino acid
SAM40697_RS28515	COG1140	nitrate reductase beta subunit
SAM40697_RS28545	COG2154	pterin-4-alpha-carbinolamine dehydratase
SAM40697_RS28550	COG2226	methyltransferase
SAM40697_RS28555	COG3401	FG-GAP repeat protein
SAM40697_RS28570	COG4733	cellulase activity
SAM40697_RS28570	COG5297	Belongs to the glycosyl hydrolase family 6
SAM40697_RS28575	COG5297	Belongs to the glycosyl hydrolase family 6
SAM40697_RS28580	COG2226	methyltransferase
SAM40697_RS28585	COG0656	L-ascorbic acid biosynthetic process
SAM40697_RS28610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAM40697_RS28620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM40697_RS28635	COG1129	ABC transporter
SAM40697_RS28640	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAM40697_RS28650	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS28715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAM40697_RS28730	COG0714	Associated with various cellular activities
SAM40697_RS28735	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAM40697_RS28810	COG0747	negative chemotaxis
SAM40697_RS28815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS28830	COG1183	phosphatidylcholine synthase activity
SAM40697_RS28845	COG0297	glycogen (starch) synthase activity
SAM40697_RS28865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAM40697_RS28875	COG0477	Major facilitator Superfamily
SAM40697_RS28885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAM40697_RS28890	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAM40697_RS28890	COG1082	Xylose isomerase domain protein TIM barrel
SAM40697_RS28900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAM40697_RS28905	COG0166	Belongs to the GPI family
SAM40697_RS28920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAM40697_RS28935	COG1486	melibiose metabolic process
SAM40697_RS28945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAM40697_RS28990	COG3938	Belongs to the proline racemase family
SAM40697_RS29000	COG1414	Transcriptional regulator
SAM40697_RS29005	COG0515	serine threonine protein kinase
SAM40697_RS29015	COG1132	(ABC) transporter
SAM40697_RS29020	COG1132	(ABC) transporter
SAM40697_RS29025	COG2197	response regulator
SAM40697_RS29030	COG0477	Major facilitator Superfamily
SAM40697_RS29035	COG3511	phospholipase C
SAM40697_RS29065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS29070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS29075	COG3485	protocatechuate 3,4-dioxygenase
SAM40697_RS29080	COG3485	protocatechuate 3,4-dioxygenase
SAM40697_RS29085	COG0183	Belongs to the thiolase family
SAM40697_RS29105	COG1470	cell adhesion involved in biofilm formation
SAM40697_RS29115	COG1793	dna ligase
SAM40697_RS29160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAM40697_RS29165	COG0488	(ABC) transporter
SAM40697_RS29180	COG4447	cellulose binding
SAM40697_RS29195	COG1515	deoxyribonuclease V activity
SAM40697_RS29210	COG3268	Saccharopine dehydrogenase
SAM40697_RS29215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAM40697_RS29220	COG0183	Belongs to the thiolase family
SAM40697_RS29225	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS29225	COG1024	Enoyl-CoA hydratase
SAM40697_RS29235	COG1113	amino acid transport
SAM40697_RS29240	COG2936	dipeptidyl-peptidase activity
SAM40697_RS29250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SAM40697_RS29265	COG0488	(ABC) transporter
SAM40697_RS29270	COG2183	response to ionizing radiation
SAM40697_RS29290	COG1024	Enoyl-CoA hydratase
SAM40697_RS29300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAM40697_RS29340	COG1134	teichoic acid transport
SAM40697_RS29345	COG1562	ergosterol biosynthetic process
SAM40697_RS29355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAM40697_RS29365	COG1657	PFAM Prenyltransferase squalene oxidase
SAM40697_RS29380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAM40697_RS29385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAM40697_RS29405	COG2365	Tyrosine phosphatase family
SAM40697_RS29425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAM40697_RS29440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAM40697_RS29470	COG1063	alcohol dehydrogenase
SAM40697_RS29475	COG0156	8-amino-7-oxononanoate synthase activity
SAM40697_RS29480	COG0583	DNA-binding transcription factor activity
SAM40697_RS29505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAM40697_RS29505	COG2111	Na H antiporter
SAM40697_RS29510	COG1006	Multisubunit Na H antiporter MnhC subunit
SAM40697_RS29515	COG0651	ATP synthesis coupled electron transport
SAM40697_RS29530	COG1320	monovalent cation:proton antiporter activity
SAM40697_RS29545	COG0174	glutamine synthetase
SAM40697_RS29565	COG2267	carboxylic ester hydrolase activity
SAM40697_RS29570	COG0183	Belongs to the thiolase family
SAM40697_RS29575	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS29580	COG0455	bacterial-type flagellum organization
SAM40697_RS29615	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SAM40697_RS29630	COG1192	Involved in chromosome partitioning
SAM40697_RS29760	COG2188	Transcriptional regulator
SAM40697_RS29765	COG3962	Belongs to the TPP enzyme family
SAM40697_RS29770	COG3718	enzyme involved in inositol metabolism
SAM40697_RS29780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM40697_RS29805	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SAM40697_RS29810	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS29815	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS29830	COG0385	Bile acid
SAM40697_RS29845	COG2197	response regulator
SAM40697_RS29855	COG1404	Belongs to the peptidase S8 family
SAM40697_RS29875	COG2838	Isocitrate dehydrogenase
SAM40697_RS29880	COG0668	transmembrane transport
SAM40697_RS29890	COG1132	(ABC) transporter
SAM40697_RS29900	COG0366	Alpha amylase catalytic
SAM40697_RS29905	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS29910	COG1175	transmembrane transport
SAM40697_RS29915	COG1653	transport
SAM40697_RS29940	COG2186	Transcriptional regulator
SAM40697_RS29945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAM40697_RS29950	COG0800	Aldolase
SAM40697_RS29955	COG4948	Mandelate Racemase Muconate Lactonizing
SAM40697_RS29960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAM40697_RS29965	COG1231	oxidoreductase activity
SAM40697_RS29975	COG1063	alcohol dehydrogenase
SAM40697_RS29980	COG0477	Major facilitator Superfamily
SAM40697_RS29985	COG0246	Mannitol dehydrogenase
SAM40697_RS30000	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAM40697_RS30005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SAM40697_RS30010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SAM40697_RS30015	COG0583	DNA-binding transcription factor activity
SAM40697_RS30020	COG0183	Belongs to the thiolase family
SAM40697_RS30025	COG0477	Major facilitator Superfamily
SAM40697_RS30060	COG0210	DNA helicase
SAM40697_RS30070	COG1401	restriction endodeoxyribonuclease activity
SAM40697_RS30090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAM40697_RS30100	COG1401	restriction endodeoxyribonuclease activity
SAM40697_RS30140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SAM40697_RS30145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAM40697_RS30180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SAM40697_RS30195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAM40697_RS30215	COG0297	glycogen (starch) synthase activity
SAM40697_RS30220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAM40697_RS30245	COG0154	amidase activity
SAM40697_RS30265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAM40697_RS30295	COG0596	Alpha beta hydrolase
SAM40697_RS30300	COG0531	amino acid
SAM40697_RS30310	COG0726	polysaccharide deacetylase
SAM40697_RS30350	COG0583	DNA-binding transcription factor activity
SAM40697_RS30360	COG1053	succinate dehydrogenase
SAM40697_RS30365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAM40697_RS30390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS30400	COG3360	Dodecin
SAM40697_RS30405	COG2182	Extracellular solute-binding protein
SAM40697_RS30410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SAM40697_RS30415	COG0121	glutamine amidotransferase
SAM40697_RS30420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SAM40697_RS30440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAM40697_RS30470	COG0596	Alpha beta hydrolase
SAM40697_RS30475	COG3903	Transcriptional regulator
SAM40697_RS30475	COG3629	intracellular signal transduction
SAM40697_RS30485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAM40697_RS30510	COG1609	Transcriptional regulator
SAM40697_RS30515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAM40697_RS30525	COG0242	peptide deformylase activity
SAM40697_RS30545	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS30550	COG1132	(ABC) transporter
SAM40697_RS30555	COG1132	(ABC) transporter
SAM40697_RS30560	COG2197	response regulator
SAM40697_RS30570	COG1012	belongs to the aldehyde dehydrogenase family
SAM40697_RS30580	COG0167	dihydroorotate dehydrogenase activity
SAM40697_RS30595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAM40697_RS30600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM40697_RS30615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAM40697_RS30630	COG4106	trans-aconitate 2-methyltransferase activity
SAM40697_RS30660	COG0500	methyltransferase
SAM40697_RS30705	COG1846	Transcriptional regulator
SAM40697_RS30710	COG2409	Drug exporters of the RND superfamily
SAM40697_RS30735	COG0668	transmembrane transport
SAM40697_RS30745	COG0514	ATP-dependent DNA helicase (RecQ)
SAM40697_RS30780	COG3540	Alkaline phosphatase
SAM40697_RS30815	COG0542	response to heat
SAM40697_RS30825	COG1136	(ABC) transporter
SAM40697_RS30825	COG0577	efflux transmembrane transporter activity
SAM40697_RS30830	COG1609	Transcriptional regulator
SAM40697_RS30845	COG1357	PFAM Pentapeptide repeats (8 copies)
SAM40697_RS30855	COG1309	transcriptional regulator
SAM40697_RS30865	COG2706	6-phosphogluconolactonase activity
SAM40697_RS30910	COG1796	DNA polymerase
SAM40697_RS30910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SAM40697_RS30915	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS30945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAM40697_RS30985	COG2124	cytochrome p450
SAM40697_RS31000	COG0435	Glutathione S-transferase
SAM40697_RS31020	COG2124	cytochrome p450
SAM40697_RS31045	COG0667	Aldo Keto reductase
SAM40697_RS31060	COG3250	beta-galactosidase activity
SAM40697_RS31085	COG1304	FMN binding
SAM40697_RS31100	COG2890	protein-(glutamine-N5) methyltransferase activity
SAM40697_RS31115	COG0248	Ppx GppA phosphatase
SAM40697_RS31200	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS31210	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS31250	COG1309	transcriptional regulator
SAM40697_RS31280	COG0572	uridine kinase
SAM40697_RS31335	COG1819	glycosyl
SAM40697_RS31340	COG0789	Transcriptional regulator
SAM40697_RS31365	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS31385	COG2508	Transcriptional regulator
SAM40697_RS31390	COG0410	ABC transporter
SAM40697_RS31395	COG0411	ABC transporter
SAM40697_RS31440	COG1132	(ABC) transporter
SAM40697_RS31485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAM40697_RS31490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAM40697_RS31495	COG2080	2 iron, 2 sulfur cluster binding
SAM40697_RS31510	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS31515	COG1295	ribonuclease BN
SAM40697_RS31530	COG3344	reverse transcriptase
SAM40697_RS31550	COG0477	Major facilitator Superfamily
SAM40697_RS31560	COG3290	protein histidine kinase activity
SAM40697_RS31600	COG0277	FAD linked oxidase domain protein
SAM40697_RS31605	COG1597	lipid kinase activity
SAM40697_RS31625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAM40697_RS31630	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS31635	COG1175	transmembrane transport
SAM40697_RS31705	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS31715	COG3397	chitin binding
SAM40697_RS31735	COG2072	flavoprotein involved in K transport
SAM40697_RS31750	COG0488	(ABC) transporter
SAM40697_RS31775	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SAM40697_RS31795	COG2235	arginine
SAM40697_RS31845	COG0505	Belongs to the CarA family
SAM40697_RS31860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM40697_RS31865	COG1191	sigma factor activity
SAM40697_RS31885	COG0783	Belongs to the Dps family
SAM40697_RS31890	COG0655	NAD(P)H dehydrogenase (quinone) activity
SAM40697_RS31910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAM40697_RS31935	COG1090	epimerase
SAM40697_RS31940	COG2124	cytochrome p450
SAM40697_RS31945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAM40697_RS31950	COG0142	geranyltranstransferase activity
SAM40697_RS31965	COG0142	geranyltranstransferase activity
SAM40697_RS32000	COG2271	Major facilitator Superfamily
SAM40697_RS32015	COG0789	Transcriptional regulator
SAM40697_RS32050	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS32055	COG2205	protein histidine kinase activity
SAM40697_RS32060	COG2340	Cysteine-rich secretory protein family
SAM40697_RS32065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAM40697_RS32070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS32085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SAM40697_RS32110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAM40697_RS32115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAM40697_RS32125	COG0438	transferase activity, transferring glycosyl groups
SAM40697_RS32145	COG0667	Aldo Keto reductase
SAM40697_RS32155	COG2326	polyphosphate kinase activity
SAM40697_RS32165	COG0739	heme binding
SAM40697_RS32165	COG1196	nuclear chromosome segregation
SAM40697_RS32165	COG0741	lytic transglycosylase activity
SAM40697_RS32185	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS32190	COG1175	transmembrane transport
SAM40697_RS32195	COG2182	Extracellular solute-binding protein
SAM40697_RS32200	COG2188	Transcriptional regulator
SAM40697_RS32205	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS32225	COG1278	Cold shock
SAM40697_RS32245	COG3386	PFAM SMP-30 Gluconolaconase
SAM40697_RS32280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAM40697_RS32290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAM40697_RS32300	COG0513	Belongs to the DEAD box helicase family
SAM40697_RS32325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAM40697_RS32330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS32335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAM40697_RS32340	COG1120	ATPase activity
SAM40697_RS32345	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SAM40697_RS32350	COG1132	(ABC) transporter
SAM40697_RS32360	COG1132	(ABC) transporter
SAM40697_RS32370	COG2382	esterase
SAM40697_RS32390	COG1984	allophanate hydrolase subunit 2
SAM40697_RS32395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAM40697_RS32400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAM40697_RS32415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SAM40697_RS32425	COG2267	carboxylic ester hydrolase activity
SAM40697_RS32445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SAM40697_RS32450	COG1263	PTS System
SAM40697_RS32450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAM40697_RS32495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS32505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SAM40697_RS32510	COG0142	geranyltranstransferase activity
SAM40697_RS32525	COG0702	epimerase
SAM40697_RS32535	COG1595	DNA-templated transcription, initiation
SAM40697_RS32575	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS32585	COG1609	Transcriptional regulator
SAM40697_RS32600	COG3250	beta-galactosidase activity
SAM40697_RS32615	COG1278	Cold shock
SAM40697_RS32620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SAM40697_RS32635	COG2197	response regulator
SAM40697_RS32640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS32645	COG0318	PFAM AMP-dependent synthetase and ligase
SAM40697_RS32665	COG2124	cytochrome p450
SAM40697_RS32690	COG0604	alcohol dehydrogenase
SAM40697_RS32690	COG3321	synthase
SAM40697_RS32710	COG1131	(ABC) transporter
SAM40697_RS32720	COG4585	Histidine kinase
SAM40697_RS32725	COG2197	response regulator
SAM40697_RS32735	COG0604	alcohol dehydrogenase
SAM40697_RS32735	COG3321	synthase
SAM40697_RS32775	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS32780	COG4948	Mandelate Racemase Muconate Lactonizing
SAM40697_RS32795	COG1132	(ABC) transporter
SAM40697_RS32800	COG0574	Belongs to the PEP-utilizing enzyme family
SAM40697_RS32800	COG3848	Pyruvate phosphate dikinase
SAM40697_RS32805	COG4709	membrane
SAM40697_RS32830	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS32835	COG0596	Alpha beta hydrolase
SAM40697_RS32855	COG3896	Chloramphenicol phosphotransferase-like protein
SAM40697_RS32860	COG1595	DNA-templated transcription, initiation
SAM40697_RS32865	COG2353	YceI-like domain
SAM40697_RS32875	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAM40697_RS32880	COG3766	membrane
SAM40697_RS32915	COG1127	ABC transporter
SAM40697_RS32925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SAM40697_RS32950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SAM40697_RS32985	COG1960	acyl-CoA dehydrogenase activity
SAM40697_RS33000	COG4106	trans-aconitate 2-methyltransferase activity
SAM40697_RS33030	COG0765	amino acid transport
SAM40697_RS33035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS33050	COG0765	amino acid transport
SAM40697_RS33060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAM40697_RS33065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS33070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS33075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS33080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAM40697_RS33090	COG0431	NADPH-dependent FMN reductase
SAM40697_RS33095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM40697_RS33120	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS33145	COG0456	acetyltransferase
SAM40697_RS33165	COG1121	(ABC) transporter
SAM40697_RS33175	COG1472	Belongs to the glycosyl hydrolase 3 family
SAM40697_RS33195	COG2130	NADP-dependent
SAM40697_RS33210	COG0778	Nitroreductase
SAM40697_RS33240	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS33245	COG3321	synthase
SAM40697_RS33245	COG0604	alcohol dehydrogenase
SAM40697_RS33260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAM40697_RS33290	COG2182	Extracellular solute-binding protein
SAM40697_RS33295	COG1175	transmembrane transport
SAM40697_RS33300	COG3833	ABC-type maltose transport systems, permease component
SAM40697_RS33305	COG2723	6-phospho-beta-galactosidase activity
SAM40697_RS33310	COG1959	2 iron, 2 sulfur cluster binding
SAM40697_RS33495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAM40697_RS33525	COG4521	taurine ABC transporter
SAM40697_RS33530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAM40697_RS33535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAM40697_RS33560	COG2124	cytochrome p450
SAM40697_RS33565	COG0243	molybdopterin cofactor binding
SAM40697_RS33590	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS33610	COG0730	response to heat
SAM40697_RS33635	COG3321	synthase
SAM40697_RS33635	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS33635	COG0604	alcohol dehydrogenase
SAM40697_RS33655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAM40697_RS33665	COG0667	Aldo Keto reductase
SAM40697_RS33675	COG2353	YceI-like domain
SAM40697_RS33710	COG1280	lysine exporter protein (LysE YggA)
SAM40697_RS33725	COG3293	Transposase
SAM40697_RS33750	COG1309	transcriptional regulator
SAM40697_RS33775	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS33780	COG1366	Belongs to the anti-sigma-factor antagonist family
SAM40697_RS33785	COG2172	sigma factor antagonist activity
SAM40697_RS33800	COG4221	oxidoreductase activity
SAM40697_RS33810	COG0667	Aldo Keto reductase
SAM40697_RS33830	COG1802	Transcriptional regulator
SAM40697_RS33840	COG0601	transmembrane transport
SAM40697_RS33845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAM40697_RS33860	COG4948	Mandelate Racemase Muconate Lactonizing
SAM40697_RS33870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SAM40697_RS33880	COG0277	FAD linked oxidase domain protein
SAM40697_RS33885	COG0247	lactate metabolic process
SAM40697_RS33895	COG1609	Transcriptional regulator
SAM40697_RS33895	COG2207	Transcriptional regulator
SAM40697_RS33905	COG0673	inositol 2-dehydrogenase activity
SAM40697_RS33955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAM40697_RS33965	COG1653	transport
SAM40697_RS33970	COG0395	ABC-type sugar transport system, permease component
SAM40697_RS33975	COG4209	transmembrane transport
SAM40697_RS33995	COG2723	6-phospho-beta-galactosidase activity
SAM40697_RS34015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SAM40697_RS34020	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SAM40697_RS34025	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SAM40697_RS34045	COG0598	Magnesium transport protein CorA
SAM40697_RS34050	COG0598	Magnesium transport protein CorA
SAM40697_RS34075	COG0477	Major facilitator Superfamily
SAM40697_RS34080	COG0662	Cupin 2, conserved barrel domain protein
SAM40697_RS34090	COG3293	Transposase
SAM40697_RS34125	COG1309	transcriptional regulator
SAM40697_RS34130	COG0110	maltose O-acetyltransferase activity
SAM40697_RS34145	COG0583	DNA-binding transcription factor activity
SAM40697_RS34165	COG1733	regulation of RNA biosynthetic process
SAM40697_RS34190	COG1278	Cold shock
SAM40697_RS34230	COG1309	transcriptional regulator
SAM40697_RS34285	COG1733	regulation of RNA biosynthetic process
SAM40697_RS34305	COG3226	Transcriptional regulator
SAM40697_RS34325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAM40697_RS34340	COG3629	intracellular signal transduction
SAM40697_RS34355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS34360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS34420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAM40697_RS34505	COG0154	amidase activity
SAM40697_RS34515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS34525	COG0745	RESPONSE REGULATOR receiver
SAM40697_RS34545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAM40697_RS34565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAM40697_RS34570	COG3903	Transcriptional regulator
SAM40697_RS34570	COG3629	intracellular signal transduction
SAM40697_RS34575	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS34605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAM40697_RS34715	COG0494	nUDIX hydrolase
SAM40697_RS34760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAM40697_RS34785	COG0513	Belongs to the DEAD box helicase family
SAM40697_RS34790	COG1278	Cold shock
SAM40697_RS34800	COG1028	Short-chain dehydrogenase reductase Sdr
SAM40697_RS34865	COG2208	phosphoserine phosphatase activity
SAM40697_RS34865	COG2770	Histidine kinase
SAM40697_RS34875	COG0142	geranyltranstransferase activity
SAM40697_RS34900	COG1131	(ABC) transporter
SAM40697_RS34905	COG1335	isochorismatase
SAM40697_RS34910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAM40697_RS34925	COG1278	Cold shock
SAM40697_RS34985	COG0702	epimerase
SAM40697_RS35000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAM40697_RS35040	COG4946	Tricorn protease homolog
SAM40697_RS35040	COG1506	peptidase
SAM40697_RS35040	COG0823	Involved in the tonB-independent uptake of proteins
SAM40697_RS35070	COG2814	Major facilitator Superfamily
SAM40697_RS35165	COG0492	ferredoxin-NADP+ reductase activity
SAM40697_RS35170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAM40697_RS35180	COG0798	PFAM Bile acid sodium symporter
SAM40697_RS35185	COG0492	ferredoxin-NADP+ reductase activity
SAM40697_RS35220	COG0640	Transcriptional regulator
SAM40697_RS35225	COG2072	flavoprotein involved in K transport
SAM40697_RS35240	COG1793	dna ligase
SAM40697_RS35260	COG0515	serine threonine protein kinase
SAM40697_RS35260	COG2815	serine threonine protein kinase