locus-tag class description HCX60_RS00020 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HCX60_RS00240 ENOG4105KVH Transcriptional regulator HCX60_RS00265 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HCX60_RS00295 ENOG410847I Transcriptional regulator, BadM Rrf2 family HCX60_RS00340 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HCX60_RS00355 ENOG4108KPJ rna polymerase sigma factor HCX60_RS00415 ENOG4108KPJ rna polymerase sigma factor HCX60_RS00425 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HCX60_RS00490 ENOG4105DBI uridine monophosphokinase HCX60_RS00550 ENOG4105ECY inositol monophosphatase HCX60_RS00610 ENOG4107RSM transcriptional regulator HCX60_RS00620 ENOG4108X0B nad(p)h dehydrogenase (quinone) HCX60_RS00640 ENOG41068WN HCX60_RS00660 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS00665 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HCX60_RS00685 ENOG4107TXC Transcriptional regulator HCX60_RS00750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS00755 ENOG4105C3U ABC transporter HCX60_RS00770 ENOG4105DTQ mandelate racemase muconate lactonizing HCX60_RS00775 ENOG4108ME1 Peptidase M55 D-aminopeptidase HCX60_RS00785 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HCX60_RS00825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS00845 ENOG4108K8K Transcriptional regulator HCX60_RS00850 ENOG4105DTQ mandelate racemase muconate lactonizing HCX60_RS00910 ENOG4107TXC Transcriptional regulator HCX60_RS00925 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HCX60_RS00930 ENOG41082YX Transcriptional regulator, arsr family HCX60_RS00935 ENOG41089UC methyltransferase, type 11 HCX60_RS00975 ENOG4105EZR dyp-type peroxidase family protein HCX60_RS00985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCX60_RS01015 ENOG410804X Transcriptional regulator HCX60_RS01020 ENOG4105CH6 catalase HCX60_RS01030 ENOG4108IUM Glycogen debranching enzyme HCX60_RS01035 ENOG4105EYF MMPL domain protein HCX60_RS01040 ENOG41067SE Tetr family transcriptional regulator HCX60_RS01075 ENOG4105C26 Dehydrogenase HCX60_RS01095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCX60_RS01110 ENOG4105EJ2 Transcriptional regulator HCX60_RS01155 ENOG4105DRR Transcriptional regulator, GntR family HCX60_RS01175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HCX60_RS01185 ENOG4105CUV Homoserine Kinase HCX60_RS01195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HCX60_RS01205 ENOG4105YA8 Transcriptional regulator HCX60_RS01210 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HCX60_RS01235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS01240 ENOG4105C3U ABC transporter HCX60_RS01245 ENOG4108JQ6 ABC transporter HCX60_RS01270 ENOG4107R37 Glutamate dehydrogenase HCX60_RS01300 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HCX60_RS01335 ENOG4107S5I aldo keto reductase HCX60_RS01340 ENOG4105DYW oxidoreductase HCX60_RS01365 ENOG4105F27 Major Facilitator HCX60_RS01380 ENOG4105CSH Transporter HCX60_RS01395 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HCX60_RS01400 ENOG4108JQ1 Dehydrogenase HCX60_RS01440 ENOG41082JN Transcriptional regulator HCX60_RS01445 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HCX60_RS01450 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HCX60_RS01455 ENOG4105C7W Xanthine dehydrogenase HCX60_RS01465 ENOG4105CPC Aldo Keto reductase HCX60_RS01480 ENOG4105CPQ Dehydrogenase HCX60_RS01500 ENOG4105E98 transcriptional regulator DeoR family HCX60_RS01505 ENOG4105C02 permease HCX60_RS01525 ENOG4105C1J atp-dependent rna helicase HCX60_RS01545 ENOG4108R85 Short chain dehydrogenase HCX60_RS01565 ENOG4105CJA serine threonine protein kinase HCX60_RS01595 ENOG4105CVN desaturase HCX60_RS01640 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HCX60_RS01645 ENOG4108Z6Z Transcriptional regulator HCX60_RS01655 ENOG4105CG3 alpha amylase, catalytic region HCX60_RS01660 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HCX60_RS01665 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HCX60_RS01690 ENOG4105CWX Alpha-1,2-mannosidase HCX60_RS01720 ENOG4105CNN ABC, transporter HCX60_RS01725 ENOG4107R9N ABC transporter HCX60_RS01730 ENOG4105C2J ABC transporter HCX60_RS01735 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCX60_RS01740 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS01745 ENOG4105BZP glycoside hydrolase 15-related HCX60_RS01750 ENOG4105C57 major facilitator superfamily HCX60_RS01755 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HCX60_RS01785 ENOG4107YZX Universal stress protein HCX60_RS01825 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HCX60_RS01830 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCX60_RS01850 ENOG4105CFG Acts as a chaperone (By similarity) HCX60_RS01895 ENOG4105E2A Dehydrogenase HCX60_RS01900 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCX60_RS01935 ENOG4105C7W Xanthine dehydrogenase HCX60_RS01955 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HCX60_RS01960 ENOG4105DFW ABC transporter HCX60_RS01965 ENOG4105DG4 malate L-lactate dehydrogenase HCX60_RS01980 ENOG4105D5U fad dependent oxidoreductase HCX60_RS02005 ENOG4107YUH hydrolase HCX60_RS02025 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase HCX60_RS02030 ENOG4105CR8 Transcriptional regulator HCX60_RS02035 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCX60_RS02040 ENOG4105CNN ABC, transporter HCX60_RS02065 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS02075 ENOG4105DAE Methylenetetrahydrofolate reductase HCX60_RS02080 ENOG410800I Aminomethyltransferase HCX60_RS02090 ENOG4105CR8 Transcriptional regulator HCX60_RS02115 ENOG4105BZU Histidine kinase HCX60_RS02120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS02130 ENOG4105CJ1 ABC, transporter HCX60_RS02135 ENOG4105EBR Carboxylesterase HCX60_RS02140 ENOG4108IXY short-chain dehydrogenase reductase HCX60_RS02160 ENOG4108YYC ycei family HCX60_RS02185 ENOG4108RU0 short-chain dehydrogenase reductase HCX60_RS02190 ENOG4105CHR reductase HCX60_RS02210 ENOG4105DQ4 alcohol dehydrogenase HCX60_RS02260 ENOG4108HWW ABC transporter HCX60_RS02265 ENOG4105DFW ABC transporter HCX60_RS02270 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCX60_RS02290 ENOG4108KEZ Dehydrogenase HCX60_RS02365 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HCX60_RS02390 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS02445 ENOG4105BZ7 extracellular solute-binding protein family 1 HCX60_RS02455 ENOG4106T9R serine protease HCX60_RS02460 ENOG4105K4I Scp-like extracellular HCX60_RS02470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCX60_RS02480 ENOG4105EV4 Multidrug resistance protein mdtH HCX60_RS02505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HCX60_RS02530 ENOG4105BZU Histidine kinase HCX60_RS02535 ENOG4105DQE DNA ligase HCX60_RS02540 ENOG4108Z0Z intracellular protease Pfpi family HCX60_RS02545 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HCX60_RS02565 ENOG4105GTG Isochorismatase HCX60_RS02580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCX60_RS02595 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HCX60_RS02675 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS02680 ENOG4105EHG Permease protein HCX60_RS02740 ENOG4106A3M Cytochrome p-450 HCX60_RS02750 ENOG4108IG5 Transcriptional regulator HCX60_RS02755 ENOG4107RTD sua5 ycio yrdc ywlc family protein HCX60_RS02805 ENOG4105DQE DNA ligase HCX60_RS02815 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HCX60_RS02850 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HCX60_RS02865 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCX60_RS02870 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HCX60_RS02955 ENOG4105BZU Histidine kinase HCX60_RS02970 ENOG4105K78 MarR family Transcriptional regulator HCX60_RS02990 ENOG4105C5X domain protein HCX60_RS03060 ENOG4107QPV Serine Threonine protein kinase HCX60_RS03070 ENOG4108R5S membrane HCX60_RS03080 ENOG4105CPC Aldo Keto reductase HCX60_RS03090 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCX60_RS03110 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCX60_RS03120 ENOG4105ESN nucleotide-binding protein HCX60_RS03130 ENOG4108PA7 Methyltransferase HCX60_RS03140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCX60_RS03145 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCX60_RS03150 ENOG4105WBV Transcriptional regulator HCX60_RS03155 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS03170 ENOG4105IDI abc transporter atp-binding protein HCX60_RS03185 ENOG4105CPC Aldo Keto reductase HCX60_RS03190 ENOG4108M0I Transcriptional regulator HCX60_RS03200 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HCX60_RS03205 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HCX60_RS03250 ENOG4105C32 Amino acid ABC transporter (Permease) HCX60_RS03260 ENOG4105C0Z ABC transporter HCX60_RS03265 ENOG4108IV0 ABC, transporter HCX60_RS03275 ENOG4105FBW Monooxygenase HCX60_RS03305 ENOG4105CGD Nad-dependent epimerase dehydratase HCX60_RS03310 ENOG4105CVP deoxyribo-dipyrimidine photolyase HCX60_RS03370 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCX60_RS03380 ENOG4107P5I polyketide synthase HCX60_RS03390 ENOG4107RCI amp-dependent synthetase and ligase HCX60_RS03400 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HCX60_RS03405 ENOG4105KF0 sporulation and cell division protein, SsgA HCX60_RS03460 ENOG4105E39 Enoyl-CoA hydratase HCX60_RS03475 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS03535 ENOG4105X7H acyl-CoA dehydrogenase HCX60_RS03560 ENOG4105CSR polyphosphate kinase 2 HCX60_RS03565 ENOG4105BZU Histidine kinase HCX60_RS03575 ENOG4107QRI Phosphoketolase HCX60_RS03580 ENOG4108YZG isomerase HCX60_RS03595 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS03605 ENOG4105WQI isochorismatase HCX60_RS03610 ENOG4105CAS nag kinase HCX60_RS03625 ENOG4105C3I Nad-dependent epimerase dehydratase HCX60_RS03655 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HCX60_RS03665 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCX60_RS03675 ENOG4105CMT Dihydroxyacetone kinase HCX60_RS03680 ENOG4108UTZ Dihydroxyacetone kinase HCX60_RS03710 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCX60_RS03730 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HCX60_RS03745 ENOG4107QPD alcohol dehydrogenase HCX60_RS03765 ENOG4105I82 acetyl xylan esterase HCX60_RS03795 ENOG4105D7V transposase HCX60_RS03805 ENOG4106A3M Cytochrome p-450 HCX60_RS03820 ENOG4108VJY integral membrane protein HCX60_RS03825 ENOG41090CE integral membrane protein HCX60_RS03835 ENOG4105CSV Glutaminase HCX60_RS03845 ENOG41073TP transcriptional regulator HCX60_RS03850 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HCX60_RS03860 ENOG4105KJJ Uncharacterized ACR, COG1993 HCX60_RS03875 ENOG4105WAB arsR family transcriptional regulator HCX60_RS03895 ENOG4105D56 permease protein HCX60_RS03905 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS03915 ENOG41067TZ transcriptional regulator, MarR family HCX60_RS03930 ENOG4107HP6 Transcriptional regulator HCX60_RS03945 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HCX60_RS03990 ENOG4105EC3 peptidase S51, dipeptidase E HCX60_RS04005 ENOG4105CQS hydrogenase expression formation protein HypD HCX60_RS04025 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HCX60_RS04065 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HCX60_RS04080 ENOG4107QN2 dihydrolipoyl dehydrogenase HCX60_RS04090 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HCX60_RS04110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HCX60_RS04115 ENOG4107R8N Glycosyl transferase, family 2 HCX60_RS04150 ENOG4105MVE transcriptional regulator HCX60_RS04185 ENOG4105DKQ ROK family HCX60_RS04190 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HCX60_RS04200 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HCX60_RS04205 ENOG4107RDB Major Facilitator HCX60_RS04210 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HCX60_RS04240 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS04245 ENOG4105BZU Histidine kinase HCX60_RS04265 ENOG4107PP3 Acetylornithine deacetylase HCX60_RS04270 ENOG4105I1F Resistance protein HCX60_RS04285 ENOG41060NJ transcriptional regulator HCX60_RS04310 ENOG4105C10 Electron transfer flavoprotein HCX60_RS04335 ENOG4105PSQ Acyl-transferase HCX60_RS04360 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HCX60_RS04400 ENOG410841Q phosphoesterase PA-phosphatase related protein HCX60_RS04455 ENOG4105CSU acyl-Coa dehydrogenase HCX60_RS04475 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HCX60_RS04515 ENOG4107AQZ Membrane HCX60_RS04525 ENOG4105VEQ Cold shock protein HCX60_RS04555 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HCX60_RS04565 ENOG4105BZP glycoside hydrolase 15-related HCX60_RS04580 ENOG4105CNN ABC, transporter HCX60_RS04585 ENOG4105C2J ABC transporter HCX60_RS04590 ENOG4108MJI response regulator HCX60_RS04610 ENOG4105E2Y ABC, transporter HCX60_RS04615 ENOG4105H3G oxidoreductase HCX60_RS04625 ENOG4105BZ1 (ABC) transporter HCX60_RS04645 ENOG4105BZ1 (ABC) transporter HCX60_RS04670 ENOG4105C29 acyl-CoA thioesterase HCX60_RS04680 ENOG4105GWZ Roadblock lc7 family protein HCX60_RS04705 ENOG4105BZU Histidine kinase HCX60_RS04740 ENOG4105C0D helicase HCX60_RS04770 ENOG4105E2R ROK family HCX60_RS04780 ENOG4107RR1 TRANSCRIPTIONal HCX60_RS04785 ENOG4105C26 Dehydrogenase HCX60_RS04820 ENOG4107XGZ Hydrolase HCX60_RS04830 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HCX60_RS04845 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HCX60_RS04850 ENOG4105DHI Methyltransferase HCX60_RS04870 ENOG4108IAJ Nad-dependent epimerase dehydratase HCX60_RS04880 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HCX60_RS04905 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS05295 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HCX60_RS05460 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS05465 ENOG4105VPX protein, conserved in bacteria HCX60_RS05490 ENOG4105NQG DoxX HCX60_RS05530 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HCX60_RS05535 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HCX60_RS05555 ENOG41082BM Transcriptional regulator, arsr family HCX60_RS05560 ENOG4105VDT -acetyltransferase HCX60_RS05575 ENOG4108Z6Z Transcriptional regulator HCX60_RS05595 ENOG4105H3G oxidoreductase HCX60_RS05600 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HCX60_RS05620 ENOG4105C3M thioredoxin reductase HCX60_RS05720 ENOG4107R9S Malate synthase HCX60_RS05745 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCX60_RS05760 ENOG4105WQI isochorismatase HCX60_RS05775 ENOG4105E0A ABC, transporter HCX60_RS05780 ENOG4105EHG Permease protein HCX60_RS05790 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS05795 ENOG4105WQI isochorismatase HCX60_RS05860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS05865 ENOG4105C3U ABC transporter HCX60_RS05870 ENOG4108JQ7 (ABC) transporter HCX60_RS05875 ENOG4108YV4 Universal stress protein HCX60_RS05885 ENOG4105CAQ asparagine synthetase HCX60_RS05890 ENOG4105C0I Conserved Protein HCX60_RS05915 ENOG4107SFI Major Facilitator superfamily HCX60_RS05930 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HCX60_RS05950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS05965 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HCX60_RS05990 ENOG4108KB0 deacetylase HCX60_RS06010 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HCX60_RS06025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS06035 ENOG4107QQG Dehydrogenase HCX60_RS06040 ENOG4105DKK Benzoate HCX60_RS06045 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS06055 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HCX60_RS06070 ENOG4105MC2 DSBA oxidoreductase HCX60_RS06085 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HCX60_RS06095 ENOG4105KVH Transcriptional regulator HCX60_RS06100 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HCX60_RS06105 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HCX60_RS06125 ENOG4105C0W non-ribosomal peptide synthetase HCX60_RS06130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS06145 ENOG4105ECP epimerase HCX60_RS06160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS06165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCX60_RS06185 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HCX60_RS06215 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HCX60_RS06250 ENOG4105KTE polyketide synthesis cyclase HCX60_RS06255 ENOG4108Y5I Cyclase dehydrase HCX60_RS06260 ENOG41079R3 acyl carrier protein HCX60_RS06265 ENOG4108PDG Beta-ketoacyl synthase HCX60_RS06305 ENOG4105DFW ABC transporter HCX60_RS06315 ENOG4105DFW ABC transporter HCX60_RS06320 ENOG4105C2J ABC transporter HCX60_RS06325 ENOG4108HWW ABC transporter HCX60_RS06350 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HCX60_RS06380 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HCX60_RS06385 ENOG4105CNN ABC, transporter HCX60_RS06390 ENOG4105C2J ABC transporter HCX60_RS06395 ENOG4105DKQ ROK family HCX60_RS06420 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS06425 ENOG4105D2B acyl-CoA dehydrogenase HCX60_RS06440 ENOG4105C3M thioredoxin reductase HCX60_RS06445 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HCX60_RS06465 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS06475 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCX60_RS06485 ENOG4105F1K Glutamine amidotransferase HCX60_RS06490 ENOG4105CTQ phosphohexokinase HCX60_RS06505 ENOG4108HRK Histidine kinase HCX60_RS06520 ENOG4108NEV two component transcriptional regulator, LytTR family HCX60_RS06530 ENOG4105CIK Amidinotransferase HCX60_RS06535 ENOG4105C8Y Acetylornithine aminotransferase HCX60_RS06550 ENOG4105F6E Acyl-transferase HCX60_RS06565 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HCX60_RS06575 ENOG4105CQM Urea amidohydrolase subunit alpha HCX60_RS06580 ENOG4105KI2 Urea amidohydrolase subunit beta HCX60_RS06585 ENOG4108YZ9 Urea amidohydrolase subunit gamma HCX60_RS06600 ENOG4105K4H Nlp p60 protein HCX60_RS06625 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HCX60_RS06630 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HCX60_RS06635 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HCX60_RS06640 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HCX60_RS06655 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS06660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS06665 ENOG4105FBW Monooxygenase HCX60_RS06670 ENOG4108R6G acetyltransferase HCX60_RS06695 ENOG4105C83 adenylosuccinate lyase HCX60_RS06700 ENOG4108VCA G U mismatch-specific DNA glycosylase HCX60_RS06720 ENOG4105BZU Histidine kinase HCX60_RS06725 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS06730 ENOG4105DKQ ROK family HCX60_RS06735 ENOG4105FDP GntR family transcriptional regulator HCX60_RS06740 ENOG4106HB6 Alpha beta hydrolase HCX60_RS06750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HCX60_RS06785 ENOG4105EYH Exonuclease HCX60_RS06795 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HCX60_RS06810 ENOG4105K4P CoA-binding domain protein HCX60_RS06820 ENOG41082SX arsR family transcriptional regulator HCX60_RS06840 ENOG4108UW5 maltose o-acetyltransferase HCX60_RS06845 ENOG4108Z0R Transferase HCX60_RS06855 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCX60_RS06875 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HCX60_RS06890 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HCX60_RS06910 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS06930 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HCX60_RS06965 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HCX60_RS06970 ENOG4105EP9 oxidoreductase HCX60_RS06990 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HCX60_RS06995 ENOG4108J59 Extracellular solute-binding protein, family 5 HCX60_RS07000 ENOG4105CHR reductase HCX60_RS07035 ENOG4105C5Q Transcriptional regulator HCX60_RS07045 ENOG4105CSW GntR family transcriptional regulator HCX60_RS07080 ENOG4105CHR reductase HCX60_RS07125 ENOG41086KC Transcriptional regulator HCX60_RS07135 ENOG4105JAB phenazine biosynthesis protein, phzf family HCX60_RS07165 ENOG4105F4R Transcriptional regulator mode HCX60_RS07170 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HCX60_RS07185 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCX60_RS07205 ENOG4108UW8 fha domain-containing protein HCX60_RS07255 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HCX60_RS07265 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HCX60_RS07285 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HCX60_RS07290 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HCX60_RS07295 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HCX60_RS07350 ENOG4105CFM UPF0317 protein HCX60_RS07355 ENOG4105E7W lamb ycsf family protein HCX60_RS07360 ENOG4105P4J Allophanate hydrolase, subunit 1 HCX60_RS07365 ENOG4107R7A Allophanate hydrolase subunit 2 HCX60_RS07370 ENOG41090WU lipolytic protein G-D-S-L family HCX60_RS07375 ENOG4108MJN Glycosyl Transferase HCX60_RS07390 ENOG4105JXB ankyrin repeat-containing protein HCX60_RS07410 ENOG4108VW9 Membrane HCX60_RS07420 ENOG4105DEU major facilitator superfamily HCX60_RS07425 ENOG4105Q70 HCX60_RS07435 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HCX60_RS07445 ENOG4105EW9 transcriptional regulator AsnC family HCX60_RS07505 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HCX60_RS07510 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HCX60_RS07515 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HCX60_RS07520 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HCX60_RS07545 ENOG4105E2R ROK family HCX60_RS07550 ENOG4106UW1 Major Facilitator superfamily HCX60_RS07560 ENOG4105C2W permease HCX60_RS07565 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HCX60_RS07610 ENOG4108IJ6 ABC transporter HCX60_RS07620 ENOG4105F38 ABC transporter, permease HCX60_RS07630 ENOG4108TZY GntR Family Transcriptional Regulator HCX60_RS07640 ENOG4105CUB amino acid HCX60_RS07650 ENOG4105DKT Transcriptional regulator HCX60_RS07655 ENOG4105DJV ribulose-phosphate 3-epimerase HCX60_RS07660 ENOG4105EYF MMPL domain protein HCX60_RS07670 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HCX60_RS07685 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HCX60_RS07695 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HCX60_RS07700 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HCX60_RS07710 ENOG4105SKN orotidine 5''-phosphate decarboxylase HCX60_RS07715 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HCX60_RS07720 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HCX60_RS07725 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HCX60_RS07735 ENOG4105CD3 dihydroorotase HCX60_RS07740 ENOG4105CXT aspartate transcarbamylase HCX60_RS07745 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HCX60_RS07755 ENOG410803B Involved in the transcription termination process (By similarity) HCX60_RS07760 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HCX60_RS07765 ENOG4105DC7 peptidase M24 HCX60_RS07775 ENOG4105D49 3-dehydroquinate synthase HCX60_RS07780 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HCX60_RS07785 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HCX60_RS07790 ENOG4105E2X shikimate dehydrogenase HCX60_RS07795 ENOG4105HHA aminodeoxychorismate lyase HCX60_RS07800 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HCX60_RS07805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HCX60_RS07820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HCX60_RS07835 ENOG4105CUT histidyl-tRNA synthetase HCX60_RS07845 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HCX60_RS07850 ENOG4105C99 atpase involved in dna repair HCX60_RS07865 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HCX60_RS07870 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HCX60_RS07875 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HCX60_RS07885 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HCX60_RS07890 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HCX60_RS07895 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HCX60_RS07900 ENOG4105CDY transcriptional regulatory protein HCX60_RS07905 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HCX60_RS07910 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HCX60_RS07920 ENOG4105E2K Glycosyl transferase (Group 1 HCX60_RS07925 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HCX60_RS07950 ENOG4105EYW Ion transport protein HCX60_RS07955 ENOG4105C22 threonyL-tRNA synthetase HCX60_RS07970 ENOG4108IRC dna polymerase iii HCX60_RS07990 ENOG4105EKC HCX60_RS08000 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HCX60_RS08005 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HCX60_RS08025 ENOG4105KF0 sporulation and cell division protein, SsgA HCX60_RS08115 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HCX60_RS08135 ENOG4105D01 (LipO)protein HCX60_RS08140 ENOG4108UMI ABC transporter, permease HCX60_RS08145 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS08175 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HCX60_RS08180 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS08190 ENOG4105BZU Histidine kinase HCX60_RS08195 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS08200 ENOG4105C57 major facilitator superfamily HCX60_RS08215 ENOG4105CH7 arginosuccinase HCX60_RS08225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HCX60_RS08240 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HCX60_RS08245 ENOG4105C8Y Acetylornithine aminotransferase HCX60_RS08250 ENOG4105CAS nag kinase HCX60_RS08255 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HCX60_RS08260 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HCX60_RS08280 ENOG4105T38 integral membrane protein HCX60_RS08290 ENOG4105F32 YngK protein HCX60_RS08315 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HCX60_RS08320 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HCX60_RS08325 ENOG4105BZU Histidine kinase HCX60_RS08330 ENOG4108RWN rrna methyltransferase HCX60_RS08335 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HCX60_RS08340 ENOG41084BS 50S ribosomal protein L35 HCX60_RS08345 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HCX60_RS08395 ENOG4105C5F glutamine synthetase HCX60_RS08405 ENOG4108Z86 Glutamine amidotransferase HCX60_RS08420 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HCX60_RS08430 ENOG4108HQS Glycine betaine HCX60_RS08435 ENOG4108IJ7 Glycine betaine HCX60_RS08440 ENOG4105HFS 5'-3' exonuclease HCX60_RS08455 ENOG4105D3G Pseudouridine synthase HCX60_RS08515 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HCX60_RS08520 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HCX60_RS08565 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HCX60_RS08575 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS08580 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HCX60_RS08585 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HCX60_RS08595 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HCX60_RS08600 ENOG4105E5F proteasome HCX60_RS08605 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HCX60_RS08640 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS08650 ENOG4105DEF Extracellular solute-binding protein, family 5 HCX60_RS08660 ENOG4107URF beta-phospho-glucomutase HCX60_RS08665 ENOG4105C3R Methionine synthase HCX60_RS08670 ENOG4108K8U Glycerol operon regulatory protein HCX60_RS08675 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HCX60_RS08680 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HCX60_RS08685 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HCX60_RS08690 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HCX60_RS08695 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HCX60_RS08700 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HCX60_RS08705 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HCX60_RS08715 ENOG4108JQ9 ABC transporter HCX60_RS08730 ENOG4108I5U Uridine phosphorylase HCX60_RS08735 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HCX60_RS08750 ENOG4105C8N cysteinyl-tRNA synthetase HCX60_RS08765 ENOG4108RH7 phosphoglycerate mutase HCX60_RS08770 ENOG4105D7N magnesium and cobalt transport protein CorA HCX60_RS08780 ENOG4105DYW oxidoreductase HCX60_RS08785 ENOG4105CPC Aldo Keto reductase HCX60_RS08805 ENOG4105S2J secreted protein HCX60_RS08815 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HCX60_RS08845 ENOG4105K5B UPF0225 protein HCX60_RS08850 ENOG4105C6F GntR Family Transcriptional Regulator HCX60_RS08855 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HCX60_RS08860 ENOG4105C6Z Gluconate HCX60_RS08885 ENOG4105PTV Nudix Hydrolase HCX60_RS08890 ENOG4105VG5 Membrane HCX60_RS08895 ENOG4105JP4 Inner membrane protein yidG HCX60_RS08920 ENOG4108IG5 Transcriptional regulator HCX60_RS08930 ENOG4105EHZ conserved protein UCP016719 HCX60_RS08950 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HCX60_RS08955 ENOG4108Z4X TRANSCRIPTIONal HCX60_RS08975 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS09015 ENOG4105D4T Citrate transporter HCX60_RS09020 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCX60_RS09025 ENOG4108SGK Tetr family transcriptional regulator HCX60_RS09035 ENOG4105F1J Homogentisate 1,2-dioxygenase HCX60_RS09050 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F HCX60_RS09060 ENOG4105RNG membrane HCX60_RS09065 ENOG4105K6V RNA polymerase HCX60_RS09080 ENOG41061MD high-affinity nickel-transporter HCX60_RS09085 ENOG4105D9P serine threonine protein kinase HCX60_RS09090 ENOG4108TCJ secreted hydrolase HCX60_RS09095 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS09125 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HCX60_RS09150 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HCX60_RS09155 ENOG4105C0B DNA polymerase III (alpha subunit) HCX60_RS09170 ENOG4106NMR serine protease HCX60_RS09185 ENOG4105CDA abc transporter atp-binding protein HCX60_RS09195 ENOG4108HW4 amino acid AbC transporter HCX60_RS09215 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HCX60_RS09220 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS09225 ENOG4105C57 major facilitator superfamily HCX60_RS09235 ENOG410841Q phosphoesterase PA-phosphatase related protein HCX60_RS09245 ENOG4105BZ9 Cytochrome C oxidase, subunit I HCX60_RS09250 ENOG4105MS9 Resuscitation-promoting factor HCX60_RS09265 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HCX60_RS09275 ENOG4105CAT Cytidine monophosphate kinase HCX60_RS09305 ENOG4105FE9 pseudouridine synthase HCX60_RS09310 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HCX60_RS09315 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HCX60_RS09330 ENOG4105DCF alanine dehydrogenase HCX60_RS09340 ENOG4108YZ4 nudix hydrolase HCX60_RS09345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HCX60_RS09350 ENOG4105BZP glycoside hydrolase 15-related HCX60_RS09360 ENOG4105DNP FAD linked oxidase domain protein HCX60_RS09375 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HCX60_RS09380 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HCX60_RS09400 ENOG4105E0A ABC, transporter HCX60_RS09405 ENOG4105TVJ transport system, permease HCX60_RS09410 ENOG4105DQ5 transport system permease protein HCX60_RS09415 ENOG4105DSU hydrolase HCX60_RS09450 ENOG4108VX5 3-methyladenine DNA glycosylase HCX60_RS09460 ENOG4108V1U phospholipid-binding protein HCX60_RS09480 ENOG4105DKW ABC transporter HCX60_RS09500 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS09505 ENOG4105ENE Histidine kinase HCX60_RS09510 ENOG4105EMU Dehydrogenase HCX60_RS09525 ENOG4105IDI abc transporter atp-binding protein HCX60_RS09535 ENOG4105EAC phosphoserine phosphatase HCX60_RS09540 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCX60_RS09555 ENOG4107YCY Transcriptional regulator HCX60_RS09570 ENOG4105CHR reductase HCX60_RS09575 ENOG4105D1U peptidase U62 modulator of DNA gyrase HCX60_RS09585 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HCX60_RS09605 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HCX60_RS09610 ENOG4107QN1 sodium solute HCX60_RS09625 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HCX60_RS09630 ENOG4105E2A Dehydrogenase HCX60_RS09640 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HCX60_RS09655 ENOG4105BZP glycoside hydrolase 15-related HCX60_RS09685 ENOG4105VBF alkaline shock protein HCX60_RS09705 ENOG4105C5H ABC transporter HCX60_RS09725 ENOG4107W7X Aldolase HCX60_RS09745 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HCX60_RS09755 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HCX60_RS09760 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HCX60_RS09795 ENOG4105EAD ABC transporter HCX60_RS09800 ENOG4105CT1 (ABC) transporter HCX60_RS09805 ENOG4105C5R Aminotransferase HCX60_RS09810 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HCX60_RS09815 ENOG4108JPW Aminotransferase HCX60_RS09820 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HCX60_RS09825 ENOG4105EV8 ectoine hydroxylase HCX60_RS09830 ENOG4105C9B Cysteine desulfurase HCX60_RS09855 ENOG4107HP6 Transcriptional regulator HCX60_RS09865 ENOG4105CJN penicillin-binding protein HCX60_RS09875 ENOG4105C7N Xanthine uracil vitamin C permease HCX60_RS09880 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HCX60_RS09885 ENOG4105NBR Pectinesterase HCX60_RS09890 ENOG4108J20 pectate lyase HCX60_RS09900 ENOG4105E4I Glycoside hydrolase family 28 HCX60_RS09920 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HCX60_RS09930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCX60_RS09935 ENOG4105DRR Transcriptional regulator, GntR family HCX60_RS09940 ENOG4108RQ5 Beta-lactamase domain-containing protein HCX60_RS09960 ENOG4105E9Z Nad-dependent epimerase dehydratase HCX60_RS09965 ENOG4105E98 transcriptional regulator DeoR family HCX60_RS09985 ENOG4107XBN GntR Family Transcriptional Regulator HCX60_RS10015 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCX60_RS10025 ENOG4105NAF rna polymerase sigma factor HCX60_RS10030 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HCX60_RS10035 ENOG4108RFG Tetr family transcriptional regulator HCX60_RS10040 ENOG410814C multidrug resistance protein HCX60_RS10050 ENOG4105VG1 fes assembly suf system protein HCX60_RS10055 ENOG4108UNV SUF system FeS assembly protein, NifU family HCX60_RS10060 ENOG4105C9B Cysteine desulfurase HCX60_RS10065 ENOG4105C3K feS assembly ATPase SufC HCX60_RS10075 ENOG4105JRK feS assembly protein SufD HCX60_RS10100 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HCX60_RS10120 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HCX60_RS10130 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HCX60_RS10145 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HCX60_RS10150 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HCX60_RS10155 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HCX60_RS10170 ENOG4107T3P ABC, transporter HCX60_RS10180 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HCX60_RS10200 ENOG4107QP8 phosphohexose isomerase HCX60_RS10215 ENOG4105CP7 Triose-phosphate isomerase HCX60_RS10220 ENOG4105BZA Phosphoglycerate kinase HCX60_RS10225 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HCX60_RS10235 ENOG4105CIE May be required for sporulation (By similarity) HCX60_RS10240 ENOG4105CHW UPF0052 protein HCX60_RS10245 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HCX60_RS10250 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HCX60_RS10265 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HCX60_RS10275 ENOG4107VMB Beta-lactamase domain protein HCX60_RS10280 ENOG4107R0W ABC transporter HCX60_RS10285 ENOG4105E5Q amino acid AbC transporter HCX60_RS10295 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HCX60_RS10300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HCX60_RS10305 ENOG4105CSH Transporter HCX60_RS10330 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HCX60_RS10335 ENOG4105BZU Histidine kinase HCX60_RS10340 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HCX60_RS10345 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HCX60_RS10350 ENOG4105DXI Major Facilitator superfamily HCX60_RS10355 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HCX60_RS10370 ENOG4105D7N magnesium and cobalt transport protein CorA HCX60_RS10400 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HCX60_RS10405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HCX60_RS10450 ENOG4105BZ1 (ABC) transporter HCX60_RS10490 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HCX60_RS10500 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HCX60_RS10545 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HCX60_RS10565 ENOG4105C32 Amino acid ABC transporter (Permease) HCX60_RS10570 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HCX60_RS10575 ENOG4105C0Z ABC transporter HCX60_RS10580 ENOG4108IV0 ABC, transporter HCX60_RS10610 ENOG4105CGH 5'-nucleotidase HCX60_RS10630 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HCX60_RS10640 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HCX60_RS10650 ENOG4105E39 Enoyl-CoA hydratase HCX60_RS10665 ENOG4105EA8 2-Nitropropane dioxygenase HCX60_RS10670 ENOG4105F2C Acetyl-CoA acetyltransferase HCX60_RS10675 ENOG4108RZE Tetr family transcriptional regulator HCX60_RS10680 ENOG4105CHR reductase HCX60_RS10685 ENOG4105CC9 acyl-Coa dehydrogenase HCX60_RS10705 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HCX60_RS10710 ENOG4105MUA Resistance protein HCX60_RS10735 ENOG4105CBC glutamate synthase HCX60_RS10765 ENOG4108RVA ribokinase HCX60_RS10775 ENOG4105CI0 Citrate lyase HCX60_RS10780 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HCX60_RS10790 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HCX60_RS10795 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HCX60_RS10805 ENOG4105DK0 Indole-3-glycerol phosphate synthase HCX60_RS10830 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HCX60_RS10840 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HCX60_RS10845 ENOG4108176 endoribonuclease L-psp HCX60_RS10850 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HCX60_RS10855 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HCX60_RS10865 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HCX60_RS10870 ENOG4105CIH Imidazole acetol-phosphate transaminase HCX60_RS10875 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HCX60_RS10925 ENOG4105C0B DNA polymerase III (alpha subunit) HCX60_RS10965 ENOG41082BV acetyltransferase HCX60_RS10975 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HCX60_RS10990 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HCX60_RS10995 ENOG4107VQS DivIVA family HCX60_RS11005 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HCX60_RS11010 ENOG4105DFA alanine racemase domain protein HCX60_RS11015 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HCX60_RS11020 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HCX60_RS11025 ENOG4105ME9 cell division protein FtsQ HCX60_RS11030 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HCX60_RS11040 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HCX60_RS11045 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HCX60_RS11055 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HCX60_RS11060 ENOG4105CJN penicillin-binding protein HCX60_RS11070 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HCX60_RS11080 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCX60_RS11100 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HCX60_RS11110 ENOG4105CDA abc transporter atp-binding protein HCX60_RS11120 ENOG4107Z3H Transcriptional regulator, TetR family HCX60_RS11130 ENOG4105EWK phytoene HCX60_RS11145 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HCX60_RS11175 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HCX60_RS11185 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HCX60_RS11200 ENOG4108UQY Iron-storage protein HCX60_RS11210 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HCX60_RS11225 ENOG4105C5I Dehydrogenase HCX60_RS11230 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS11260 ENOG4105DKQ ROK family HCX60_RS11270 ENOG4105D0U Arsenite-activated ATPase (ArsA) HCX60_RS11285 ENOG4108IQE Amp-dependent synthetase and ligase HCX60_RS11290 ENOG4105JNK Glycosyl transferase (Group 1 HCX60_RS11295 ENOG4105UQX Mate efflux family protein HCX60_RS11345 ENOG4108I0Q anthranilate phosphoribosyltransferase HCX60_RS11350 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HCX60_RS11355 ENOG4107EUI c reductase, iron-sulfur HCX60_RS11360 ENOG4107UDY cytochrome C HCX60_RS11365 ENOG4105CCU oxidase (Subunit III) HCX60_RS11375 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HCX60_RS11380 ENOG4105MCD Part of cytochrome c oxidase, its function is HCX60_RS11385 ENOG4105BZ9 Cytochrome C oxidase, subunit I HCX60_RS11390 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HCX60_RS11400 ENOG4107T4Z adenosine kinase HCX60_RS11420 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HCX60_RS11425 ENOG4108762 serine threonine protein kinase HCX60_RS11435 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS11440 ENOG4105BZU Histidine kinase HCX60_RS11470 ENOG4108YZT Adenosylcobinamide kinase HCX60_RS11480 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HCX60_RS11485 ENOG4105CRK lysyL-tRNA synthetase HCX60_RS11500 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HCX60_RS11505 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HCX60_RS11535 ENOG4105E6M Sulphatase-modifying factor protein HCX60_RS11540 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HCX60_RS11560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS11570 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HCX60_RS11615 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HCX60_RS11620 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HCX60_RS11640 ENOG4105C5F glutamine synthetase HCX60_RS11650 ENOG4105D0M Protease HtpX homolog HCX60_RS11680 ENOG4108222 arsenate reductase HCX60_RS11685 ENOG4106SPC secreted protein HCX60_RS11690 ENOG4107R5B glutamine synthetase HCX60_RS11695 ENOG4107NHD transcriptional regulator HCX60_RS11710 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS11745 ENOG41060BG Tetr family transcriptional regulator HCX60_RS11770 ENOG4105CG3 alpha amylase, catalytic region HCX60_RS11775 ENOG4105EG2 ABC transporter, permease HCX60_RS11790 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS11800 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HCX60_RS11810 ENOG4105C5F glutamine synthetase HCX60_RS11820 ENOG41081JD Transcriptional regulator HCX60_RS11855 ENOG4105F27 Major Facilitator HCX60_RS11870 ENOG4105C57 major facilitator superfamily HCX60_RS11875 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HCX60_RS11895 ENOG4107XZ0 Peptidase M50 HCX60_RS11935 ENOG4105EHG Permease protein HCX60_RS11940 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS11950 ENOG4105DBE peroxidase HCX60_RS11960 ENOG4106A0S HCX60_RS11980 ENOG4105C2C drug resistance transporter, Bcr CflA HCX60_RS11985 ENOG4107S1E Beta-lactamase HCX60_RS11995 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HCX60_RS12005 ENOG4105C19 ABC transporter HCX60_RS12015 ENOG4108VGI doxx family HCX60_RS12030 ENOG4107QRT dEAD DEAH box helicase HCX60_RS12175 ENOG4105EC2 ftsk spoIIIe HCX60_RS12195 ENOG4105E7U AraC family transcriptional regulator HCX60_RS12210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HCX60_RS12215 ENOG4107XFJ UPF0246 protein HCX60_RS12220 ENOG4108UHU Aldolase HCX60_RS12235 ENOG4105EGD dinuclear metal center protein, YbgI family HCX60_RS12245 ENOG4105CHR reductase HCX60_RS12270 ENOG4108S01 response regulator HCX60_RS12300 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase HCX60_RS12310 ENOG4105DYW oxidoreductase HCX60_RS12325 ENOG4107QVI Methyltransferase, type 11 HCX60_RS12330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCX60_RS12335 ENOG4108SGK Tetr family transcriptional regulator HCX60_RS12405 ENOG4105XPP Protein of unknown function (DUF1275) HCX60_RS12415 ENOG4106A3M Cytochrome p-450 HCX60_RS12420 ENOG4105F2C Acetyl-CoA acetyltransferase HCX60_RS12455 ENOG4105CNA YD repeat protein HCX60_RS12510 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HCX60_RS12540 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HCX60_RS12570 ENOG41068SY HCX60_RS12580 ENOG4105BZ4 penicillin-binding protein HCX60_RS12595 ENOG4105DAX Pfam:DUF2983 HCX60_RS12640 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HCX60_RS12670 ENOG4108FN7 Aldo keto reductase HCX60_RS12675 ENOG4105VUF Transcriptional regulator HCX60_RS12710 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HCX60_RS12730 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HCX60_RS12735 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HCX60_RS12740 ENOG4105NGS secreted protein HCX60_RS12745 ENOG4105N14 lysine exporter protein LysE YggA HCX60_RS12760 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HCX60_RS12795 ENOG4105DFW ABC transporter HCX60_RS12800 ENOG4105C2J ABC transporter HCX60_RS12805 ENOG4108HWW ABC transporter HCX60_RS12810 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HCX60_RS12815 ENOG4105CIH Imidazole acetol-phosphate transaminase HCX60_RS12890 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HCX60_RS12895 ENOG4105J4Q Transcriptional regulator HCX60_RS12915 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS12920 ENOG4105D8K carboxyl transferase HCX60_RS12935 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HCX60_RS12960 ENOG4108MRH transcriptional regulatory protein HCX60_RS12965 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HCX60_RS12985 ENOG4105SHT UspA domain-containing protein HCX60_RS13080 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS13085 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HCX60_RS13095 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HCX60_RS13105 ENOG4108UB4 uncharacterized protein ygjQ HCX60_RS13110 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCX60_RS13145 ENOG4107QZF nitrite reductase NADPH large subunit HCX60_RS13165 ENOG4107B2H carbonic anhydrase HCX60_RS13200 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HCX60_RS13210 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HCX60_RS13215 ENOG4105E2R ROK family HCX60_RS13310 ENOG4108FN7 Aldo keto reductase HCX60_RS13315 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HCX60_RS13320 ENOG4105DSE periplasmic solute binding protein HCX60_RS13325 ENOG4105FDK ABC transporter HCX60_RS13330 ENOG4105FAV ABC, transporter HCX60_RS13360 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HCX60_RS13365 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HCX60_RS13415 ENOG4105NAF rna polymerase sigma factor HCX60_RS13430 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HCX60_RS13440 ENOG4105D4Y metalloprotease HCX60_RS13470 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HCX60_RS13495 ENOG4105MSB protein, conserved in bacteria HCX60_RS13505 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HCX60_RS13515 ENOG4107T4Z adenosine kinase HCX60_RS13520 ENOG4105EQX glucarate dehydratase HCX60_RS13525 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HCX60_RS13560 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HCX60_RS13565 ENOG4107YU2 histidine triad (hIT) protein HCX60_RS13570 ENOG4107RE3 peptidase, S41 HCX60_RS13590 ENOG4107QWG 2-Nitropropane dioxygenase HCX60_RS13595 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCX60_RS13600 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HCX60_RS13635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HCX60_RS13640 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HCX60_RS13670 ENOG4105KQC Competence protein HCX60_RS13675 ENOG4105EPR degv family HCX60_RS13685 ENOG4105C8T Leucyl-tRNA synthetase HCX60_RS13695 ENOG4107QIZ NADH dehydrogenase HCX60_RS13720 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCX60_RS13725 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HCX60_RS13735 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HCX60_RS13750 ENOG4105D0M Protease HtpX homolog HCX60_RS13765 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HCX60_RS13775 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HCX60_RS13785 ENOG4105K64 Glycosyl transferase, family 2 HCX60_RS13800 ENOG4105DGI Alkaline phosphatase HCX60_RS13805 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HCX60_RS13810 ENOG4105K46 50S ribosomal protein l27 HCX60_RS13815 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HCX60_RS13840 ENOG4105J5G Transferase hexapeptide repeat containing protein HCX60_RS13855 ENOG4108IJ1 Dehydrogenase HCX60_RS13870 ENOG4105CK5 oxidoreductase HCX60_RS13875 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HCX60_RS13905 ENOG4105CNI cell division protein FtsW HCX60_RS13925 ENOG4105DFF Rod shape-determining protein mreb HCX60_RS13930 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HCX60_RS13940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HCX60_RS13950 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HCX60_RS13960 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HCX60_RS13965 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCX60_RS13970 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HCX60_RS13975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HCX60_RS13995 ENOG4108TGC Acyltransferase HCX60_RS14025 ENOG4105C85 amino acid HCX60_RS14050 ENOG4105E2R ROK family HCX60_RS14060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HCX60_RS14065 ENOG4105E2Y ABC, transporter HCX60_RS14080 ENOG4105MC2 DSBA oxidoreductase HCX60_RS14130 ENOG4107RTG Major Facilitator superfamily HCX60_RS14140 ENOG4108KTG Membrane protein, drug metabolite transporter HCX60_RS14145 ENOG4108ZT1 Transcriptional regulator HCX60_RS14150 ENOG4107SCK Monooxygenase HCX60_RS14200 ENOG4105CJ1 ABC, transporter HCX60_RS14220 ENOG4105D8X mechanosensitive ion channel HCX60_RS14235 ENOG4105E2R ROK family HCX60_RS14250 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HCX60_RS14255 ENOG4105F8D glycoside hydrolase family 4 HCX60_RS14270 ENOG4105CT1 (ABC) transporter HCX60_RS14330 ENOG4107R16 Multicopper oxidase HCX60_RS14340 ENOG4105VHU single-stranded DNA-binding protein HCX60_RS14365 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HCX60_RS14425 ENOG4105JNK Glycosyl transferase (Group 1 HCX60_RS14430 ENOG4105D3Q Sugar transferase HCX60_RS14440 ENOG4105CJR Integral membrane protein (MviN HCX60_RS14475 ENOG4105S2J secreted protein HCX60_RS14475 ENOG4105S2J secreted protein HCX60_RS14510 ENOG4105CJ1 ABC, transporter HCX60_RS14520 ENOG4105C26 Dehydrogenase HCX60_RS14525 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HCX60_RS14530 ENOG4105DH8 myo-inositol catabolism HCX60_RS14540 ENOG4105EDK PfkB domain protein HCX60_RS14545 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HCX60_RS14560 ENOG4107R13 MMPL domain protein HCX60_RS14585 ENOG4105C7H Helicase, RecD TraA family HCX60_RS14650 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HCX60_RS14660 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HCX60_RS14675 ENOG4105D17 glycoside hydrolase, family 3 domain protein HCX60_RS14705 ENOG4108K8S endonuclease I HCX60_RS14725 ENOG4108XFF HCX60_RS14730 ENOG4105C29 acyl-CoA thioesterase HCX60_RS14745 ENOG4107QX3 carboxylase HCX60_RS14755 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HCX60_RS14760 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS14775 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HCX60_RS14785 ENOG4105DUU IucA IucC family protein HCX60_RS14805 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HCX60_RS14825 ENOG4105ECQ AraC Family Transcriptional Regulator HCX60_RS14830 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HCX60_RS14850 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS14865 ENOG4105DRS transport system, permease HCX60_RS14905 ENOG4108NNZ chitinase HCX60_RS14910 ENOG410804D Sensor Signal Transduction Histidine Kinase HCX60_RS14940 ENOG4105CVJ phosphoglycerate mutase HCX60_RS15005 ENOG4105BZU Histidine kinase HCX60_RS15010 ENOG4105DEN Luciferase family HCX60_RS15060 ENOG4108M1A Chitin-binding protein HCX60_RS15105 ENOG4105D9R oxidoreductase HCX60_RS15110 ENOG41090KN UPF0303 protein HCX60_RS15130 ENOG4105NX3 Membrane HCX60_RS15135 ENOG4108U4N (sortase) family HCX60_RS15225 ENOG4105D2S major facilitator superfamily HCX60_RS15230 ENOG4106BRA Membrane HCX60_RS15245 ENOG4108IUW ABC transporter HCX60_RS15260 ENOG4105BZ4 penicillin-binding protein HCX60_RS15265 ENOG4105KPY Small multidrug resistance protein HCX60_RS15290 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HCX60_RS15300 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HCX60_RS15345 ENOG4105C85 amino acid HCX60_RS15355 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HCX60_RS15365 ENOG4108RWI nicotinamidase HCX60_RS15395 ENOG4105KF0 sporulation and cell division protein, SsgA HCX60_RS15400 ENOG4105CQB FAD linked oxidase domain protein HCX60_RS15410 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HCX60_RS15420 ENOG4105E90 ABC transporter HCX60_RS15425 ENOG4108IJ8 ABC transporter HCX60_RS15430 ENOG4105E90 ABC transporter HCX60_RS15440 ENOG41063PX domain protein HCX60_RS15515 ENOG4108C33 Resolvase HCX60_RS15525 ENOG4106JDR secreted HCX60_RS15540 ENOG4107S5I aldo keto reductase HCX60_RS15545 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HCX60_RS15560 ENOG4105E2D ec 3.2.1.52 HCX60_RS15585 ENOG4108UJU UPF0301 protein HCX60_RS15590 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HCX60_RS15595 ENOG4108426 dNA-binding protein HCX60_RS15605 ENOG4105EEM helicase HCX60_RS15630 ENOG4105DQQ Major facilitator superfamily MFS_1 HCX60_RS15660 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HCX60_RS15665 ENOG4105CN1 protease HCX60_RS15675 ENOG4105CAK Cell division ATP-binding protein ftsE HCX60_RS15690 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HCX60_RS15695 ENOG4108QVN serine threonine protein kinase HCX60_RS15720 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HCX60_RS15725 ENOG4107SJB teichoic acid biosynthesis HCX60_RS15730 ENOG4107SJB teichoic acid biosynthesis HCX60_RS15735 ENOG4107SJB teichoic acid biosynthesis HCX60_RS15750 ENOG4108ZHJ Organic hydroperoxide resistance protein HCX60_RS15755 ENOG4105K56 Transcriptional regulator HCX60_RS15785 ENOG4105EY8 ABC transporter HCX60_RS15790 ENOG4105C7I Dehydrogenase HCX60_RS15815 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HCX60_RS15825 ENOG4105T0Z Conserved Protein HCX60_RS15830 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS15835 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HCX60_RS15845 ENOG4105G3P Lipoprotein lpqB HCX60_RS15850 ENOG4105BZU Histidine kinase HCX60_RS15855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS15860 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HCX60_RS15875 ENOG4108WQ6 secreted protein HCX60_RS15880 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HCX60_RS15920 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HCX60_RS15930 ENOG4105EIP mannose-6-phosphate isomerase HCX60_RS15940 ENOG4105W49 UPF0434 protein HCX60_RS15945 ENOG4107QKV phosphomannomutase HCX60_RS15965 ENOG4107RGC Glycosyl transferase, family 2 HCX60_RS15970 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS15985 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HCX60_RS15995 ENOG4108S0S Nucleotidyl transferase HCX60_RS16010 ENOG4108KGH TRANSCRIPTIONal HCX60_RS16015 ENOG4108KGH TRANSCRIPTIONal HCX60_RS16025 ENOG4105K64 Glycosyl transferase, family 2 HCX60_RS16045 ENOG4108KGH TRANSCRIPTIONal HCX60_RS16055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCX60_RS16060 ENOG4108Z6Z Transcriptional regulator HCX60_RS16110 ENOG4105C6Y Udp-glucose 6-dehydrogenase HCX60_RS16140 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HCX60_RS16155 ENOG41065SU Two-component system sensor kinase HCX60_RS16160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS16165 ENOG4105DUX Transporter HCX60_RS16195 ENOG41082AN stage II sporulation protein HCX60_RS16200 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS16205 ENOG4105CI2 imidazolone-5-propionate hydrolase HCX60_RS16210 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HCX60_RS16220 ENOG4105CGP Urocanate hydratase HCX60_RS16270 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS16305 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS16310 ENOG4107RBB ABC transporter, permease HCX60_RS16315 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HCX60_RS16320 ENOG4105CEP NADH dehydrogenase HCX60_RS16350 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HCX60_RS16415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS16420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS16435 ENOG4107QN1 sodium solute HCX60_RS16465 ENOG4105BZU Histidine kinase HCX60_RS16475 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HCX60_RS16480 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HCX60_RS16485 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HCX60_RS16490 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HCX60_RS16500 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HCX60_RS16510 ENOG41067SE Tetr family transcriptional regulator HCX60_RS16525 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HCX60_RS16530 ENOG4108ZT1 Transcriptional regulator HCX60_RS16535 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS16555 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HCX60_RS16620 ENOG4105C5H ABC transporter HCX60_RS16625 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HCX60_RS16630 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HCX60_RS16635 ENOG41069ER domain protein HCX60_RS16640 ENOG4105F8V Hydrolase, tatD family HCX60_RS16665 ENOG4105GFG DUF218 domain HCX60_RS16715 ENOG4105DVF Cytosine-specific methyltransferase HCX60_RS16735 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HCX60_RS16750 ENOG4107XRG penicillin-binding protein HCX60_RS16755 ENOG4105KF0 sporulation and cell division protein, SsgA HCX60_RS16760 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HCX60_RS16770 ENOG4108JJB ABC transporter HCX60_RS16775 ENOG4105K56 Transcriptional regulator HCX60_RS16780 ENOG4108ZHJ Organic hydroperoxide resistance protein HCX60_RS16805 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HCX60_RS16810 ENOG4105BZU Histidine kinase HCX60_RS16820 ENOG4105EYF MMPL domain protein HCX60_RS16840 ENOG4108BAS reductase HCX60_RS16845 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HCX60_RS16850 ENOG4105F95 Monooxygenase HCX60_RS16860 ENOG4105CGK Exodeoxyribonuclease III HCX60_RS16885 ENOG4108Z9I -acetyltransferase HCX60_RS16890 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HCX60_RS16895 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HCX60_RS16905 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HCX60_RS16910 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HCX60_RS16940 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HCX60_RS16965 ENOG4105KXX peptidase s58 dmpa HCX60_RS16970 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HCX60_RS16985 ENOG4105DM4 PTS System HCX60_RS16995 ENOG410804X Transcriptional regulator HCX60_RS17020 ENOG4108Z7F N-acetyltransferase HCX60_RS17025 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HCX60_RS17060 ENOG4105CMD Transcriptional regulator, GntR family HCX60_RS17145 ENOG4107S91 Sodium hydrogen exchanger HCX60_RS17165 ENOG4105BZU Histidine kinase HCX60_RS17170 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS17180 ENOG4105DZ6 Band 7 protein HCX60_RS17205 ENOG4108V06 Glutathione peroxidase HCX60_RS17275 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HCX60_RS17285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCX60_RS17295 ENOG4105CAQ asparagine synthetase HCX60_RS17375 ENOG4105CZS beta-ketoacyl synthase HCX60_RS17385 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein HCX60_RS17395 ENOG4105DUX Transporter HCX60_RS17400 ENOG4105CHR reductase HCX60_RS17415 ENOG4105D8K carboxyl transferase HCX60_RS17505 ENOG4105CDH Citrulline--aspartate ligase HCX60_RS17510 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS17545 ENOG4105G3V Inherit from COG: Protein of unknown function (DUF433) HCX60_RS17550 ENOG4108762 serine threonine protein kinase HCX60_RS17560 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HCX60_RS17565 ENOG4108ZRZ Transcriptional regulator (AsnC family) HCX60_RS17570 ENOG4105N14 lysine exporter protein LysE YggA HCX60_RS17580 ENOG4105D2B acyl-CoA dehydrogenase HCX60_RS17595 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HCX60_RS17635 ENOG4105H3G oxidoreductase HCX60_RS17670 ENOG4105D2S major facilitator superfamily HCX60_RS17685 ENOG4105CC9 acyl-Coa dehydrogenase HCX60_RS17690 ENOG4105CHR reductase HCX60_RS17705 ENOG4105D2B acyl-CoA dehydrogenase HCX60_RS17710 ENOG4105CC9 acyl-Coa dehydrogenase HCX60_RS17730 ENOG41082AN stage II sporulation protein HCX60_RS17785 ENOG4108XEP Alpha Beta Hydrolase Fold protein HCX60_RS17795 ENOG4108SU4 UPF0309 protein HCX60_RS17820 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HCX60_RS17840 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS17855 ENOG4107QX3 carboxylase HCX60_RS17885 ENOG4105CQB FAD linked oxidase domain protein HCX60_RS17890 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HCX60_RS17935 ENOG4106R7G Glycoside hydrolase family 5 HCX60_RS17955 ENOG4105CPC Aldo Keto reductase HCX60_RS17980 ENOG4105C7N Xanthine uracil vitamin C permease HCX60_RS17990 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HCX60_RS18020 ENOG4108N0W Major Facilitator superfamily HCX60_RS18030 ENOG4108UIH futalosine nucleosidase HCX60_RS18035 ENOG4105E63 Pfam:DUF178 HCX60_RS18040 ENOG4105VEQ Cold shock protein HCX60_RS18070 ENOG4105CFI type iii restriction protein res subunit HCX60_RS18085 ENOG4105EEM helicase HCX60_RS18110 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HCX60_RS18150 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HCX60_RS18160 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HCX60_RS18180 ENOG4105C3Q Glycosyl transferase, family 2 HCX60_RS18210 ENOG4105CE4 GlcNAc 6-P deacetylase HCX60_RS18225 ENOG4105BZU Histidine kinase HCX60_RS18275 ENOG4105PTV Nudix Hydrolase HCX60_RS18300 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HCX60_RS18380 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HCX60_RS18390 ENOG4105C2N RNA methyltransferase TrmH family group 3 HCX60_RS18395 ENOG4105C8N cysteinyl-tRNA synthetase HCX60_RS18400 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HCX60_RS18405 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HCX60_RS18410 ENOG4108VJ1 Transcriptional regulator (CarD family HCX60_RS18430 ENOG4105BZU Histidine kinase HCX60_RS18455 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCX60_RS18500 ENOG4105TT9 Protein of unknown function (DUF2516) HCX60_RS18535 ENOG4105KK4 UPF0060 membrane protein HCX60_RS18570 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HCX60_RS18575 ENOG41073TP transcriptional regulator HCX60_RS18590 ENOG4105HHS UPF0256 protein HCX60_RS18600 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HCX60_RS18605 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HCX60_RS18610 ENOG41090R7 Ferric uptake HCX60_RS18615 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HCX60_RS18650 ENOG4105PKJ carbohydrate binding HCX60_RS18655 ENOG4105KHC sulfurtransferase HCX60_RS18680 ENOG4107NHD transcriptional regulator HCX60_RS18685 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS18690 ENOG4105C0H protease HCX60_RS18700 ENOG4105ETX regulatoR HCX60_RS18710 ENOG4105CGH 5'-nucleotidase HCX60_RS18715 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HCX60_RS18730 ENOG4105CJ1 ABC, transporter HCX60_RS18745 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HCX60_RS18750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS18765 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HCX60_RS18795 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS18800 ENOG4105CJ3 phosphate transporter HCX60_RS18810 ENOG4105VPX protein, conserved in bacteria HCX60_RS18830 ENOG4105DNP FAD linked oxidase domain protein HCX60_RS18835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HCX60_RS18840 ENOG4105E4C Lytic transglycosylase catalytic HCX60_RS18915 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS18955 ENOG4105D5U fad dependent oxidoreductase HCX60_RS18960 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HCX60_RS18970 ENOG4105CPC Aldo Keto reductase HCX60_RS18995 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HCX60_RS19060 ENOG4105C1J atp-dependent rna helicase HCX60_RS19095 ENOG4105CQ7 ATP-dependent helicase HCX60_RS19115 ENOG4108TAC HCX60_RS19120 ENOG4107RDP Dehydrogenase HCX60_RS19130 ENOG4105CXB phosphoribosylaminoimidazole synthetase HCX60_RS19145 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HCX60_RS19150 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HCX60_RS19155 ENOG410839H phosphoribosylformylglycinamidine synthase HCX60_RS19200 ENOG4105C8V SAICAR synthetase HCX60_RS19215 ENOG4105C12 Phosphoribosylglycinamide synthetase HCX60_RS19250 ENOG4107ZT5 Thiol disulfide interchange protein HCX60_RS19285 ENOG4105CHR reductase HCX60_RS19325 ENOG4105D7A ATP-binding protein HCX60_RS19340 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HCX60_RS19355 ENOG4108Z6B deaminase HCX60_RS19385 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein HCX60_RS19390 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS19395 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS19410 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HCX60_RS19420 ENOG410905P Pyridoxamine 5-phosphate HCX60_RS19425 ENOG4105EDW glycosyl transferase, family 39 HCX60_RS19435 ENOG4105BZU Histidine kinase HCX60_RS19440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS19510 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS19515 ENOG4105NAF rna polymerase sigma factor HCX60_RS19600 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HCX60_RS19620 ENOG4107T6F Xaa-Pro aminopeptidase HCX60_RS19655 ENOG4105DBE peroxidase HCX60_RS19660 ENOG4105CQC Prephenate dehydratase HCX60_RS19665 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HCX60_RS19670 ENOG410667J hydrolase HCX60_RS19720 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HCX60_RS19735 ENOG410667J hydrolase HCX60_RS19745 ENOG4108JJ9 ABC, transporter HCX60_RS19750 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HCX60_RS19755 ENOG4105C4M (Ubiquinol oxidase) subunit I HCX60_RS19760 ENOG4105CIH Imidazole acetol-phosphate transaminase HCX60_RS19765 ENOG4107P2S Transcriptional regulator HCX60_RS19785 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HCX60_RS19810 ENOG4106048 Cupin 2, conserved barrel domain protein HCX60_RS19815 ENOG41082T9 Membrane HCX60_RS19820 ENOG4105KJF protein tyrosine phosphatase HCX60_RS19825 ENOG4105C28 cystathionine HCX60_RS19855 ENOG4105F27 Major Facilitator HCX60_RS19875 ENOG4108XEP Alpha Beta Hydrolase Fold protein HCX60_RS19880 ENOG4105NAE bifunctional deaminase-reductase domain protein HCX60_RS19885 ENOG4105CDU Replicative dna helicase HCX60_RS19895 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HCX60_RS19900 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HCX60_RS19905 ENOG4107YH6 single-stranded DNA-binding protein HCX60_RS19910 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HCX60_RS19935 ENOG4105BZ4 penicillin-binding protein HCX60_RS19960 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HCX60_RS19975 ENOG4105D9P serine threonine protein kinase HCX60_RS19990 ENOG4105C3M thioredoxin reductase HCX60_RS19995 ENOG4105K63 Thioredoxin HCX60_RS20010 ENOG4107QJE Chromosome Partitioning Protein HCX60_RS20015 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HCX60_RS20025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HCX60_RS20030 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HCX60_RS20035 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HCX60_RS20045 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HCX60_RS20050 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HCX60_RS20055 ENOG4108J5G 6-phosphogluconate dehydrogenase HCX60_RS20060 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HCX60_RS20065 ENOG4105K7N UPF0232 protein HCX60_RS20070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCX60_RS20075 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCX60_RS20145 ENOG4108UGD Serine Threonine protein kinase HCX60_RS20175 ENOG4105ZJT Cell division protein CrgA HCX60_RS20185 ENOG4108U4N (sortase) family HCX60_RS20200 ENOG4108U4N (sortase) family HCX60_RS20205 ENOG4108RN7 integral membrane protein HCX60_RS20215 ENOG4105CJN penicillin-binding protein HCX60_RS20230 ENOG4105HZM Fha domain containing protein HCX60_RS20265 ENOG4107SCK Monooxygenase HCX60_RS20345 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HCX60_RS20375 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCX60_RS20380 ENOG4108IG5 Transcriptional regulator HCX60_RS20400 ENOG4107QSN dihydrolipoamide acetyltransferase HCX60_RS20405 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HCX60_RS20415 ENOG4107SVH Potassium channel protein HCX60_RS20445 ENOG4108VC7 Protein of unknown function (DUF2587) HCX60_RS20450 ENOG4107QPV Serine Threonine protein kinase HCX60_RS20465 ENOG4105CPP Dehydrogenase, E1 component HCX60_RS20470 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HCX60_RS20505 ENOG4105ECQ AraC Family Transcriptional Regulator HCX60_RS20525 ENOG4105DFM M18 family aminopeptidase HCX60_RS20530 ENOG4105CSU acyl-Coa dehydrogenase HCX60_RS20545 ENOG4105EUB pirin domain protein HCX60_RS20565 ENOG4105C9M aspartyl-trna synthetase HCX60_RS20575 ENOG4105KWG Pfam:DUF1696 HCX60_RS20610 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HCX60_RS20635 ENOG4107SQD Transcriptional regulator, GntR family HCX60_RS20675 ENOG4108PJD permease HCX60_RS20690 ENOG4105DU0 nucleoside hydrolase HCX60_RS20700 ENOG4105CG3 alpha amylase, catalytic region HCX60_RS20725 ENOG4105E5D amino acid HCX60_RS20810 ENOG4105CHP RNA polymerase HCX60_RS20815 ENOG4105GRZ Ycii-related protein HCX60_RS20825 ENOG4108KGH TRANSCRIPTIONal HCX60_RS20855 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HCX60_RS20880 ENOG4105ECY inositol monophosphatase HCX60_RS20910 ENOG4105C1J atp-dependent rna helicase HCX60_RS20915 ENOG4105VEQ Cold shock protein HCX60_RS21000 ENOG4105FDP GntR family transcriptional regulator HCX60_RS21015 ENOG4105DHP deoxycytidine triphosphate deaminase HCX60_RS21020 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HCX60_RS21065 ENOG4105DF6 Fe-S oxidoreductase HCX60_RS21075 ENOG4105CFG Acts as a chaperone (By similarity) HCX60_RS21080 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HCX60_RS21085 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HCX60_RS21090 ENOG4105KNI merR family transcriptional Regulator HCX60_RS21095 ENOG4105DFW ABC transporter HCX60_RS21145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCX60_RS21170 ENOG4105DA5 (ABC) transporter HCX60_RS21175 ENOG4105DA5 (ABC) transporter HCX60_RS21215 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HCX60_RS21220 ENOG4107RCW fructose-bisphosphate aldolase HCX60_RS21240 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HCX60_RS21260 ENOG4105BZU Histidine kinase HCX60_RS21265 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS21270 ENOG4105BZU Histidine kinase HCX60_RS21275 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS21285 ENOG4105DIM ABC transporter HCX60_RS21290 ENOG4105CIG ABC transporter HCX60_RS21305 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HCX60_RS21335 ENOG4108WYP Transcriptional regulator HCX60_RS21340 ENOG4108JPW Aminotransferase HCX60_RS21345 ENOG4108V4B ThiJ pfpI HCX60_RS21365 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HCX60_RS21370 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HCX60_RS21385 ENOG4105CFH Aspartokinase HCX60_RS21395 ENOG4105NAF rna polymerase sigma factor HCX60_RS21420 ENOG4108PJD permease HCX60_RS21525 ENOG4108JQC penicillin-binding protein 1A HCX60_RS21560 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HCX60_RS21580 ENOG4105P8F nudix hydrolase HCX60_RS21595 ENOG4105D74 hydrolase HCX60_RS21610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HCX60_RS21615 ENOG4107B2H carbonic anhydrase HCX60_RS21675 ENOG4108I5C dEAD DEAH box helicase HCX60_RS21680 ENOG4105WN5 stage II sporulation protein HCX60_RS21685 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HCX60_RS21690 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HCX60_RS21710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HCX60_RS21720 ENOG4105C6E dna polymerase iii HCX60_RS21725 ENOG4106JDR secreted HCX60_RS21830 ENOG4105C2M dna polymerase I HCX60_RS21855 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HCX60_RS21860 ENOG4105KDC 50s ribosomal protein l28 HCX60_RS21865 ENOG4105W0E 50S ribosomal protein L33 HCX60_RS21870 ENOG4105NRA 50s ribosomal protein l31 type b HCX60_RS21880 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HCX60_RS21900 ENOG4105C26 Dehydrogenase HCX60_RS21910 ENOG4105CVK Glutamate decarboxylase HCX60_RS21920 ENOG4107TXC Transcriptional regulator HCX60_RS21925 ENOG41082VC UPF0145 protein HCX60_RS21930 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HCX60_RS21940 ENOG4105F0N pyrophosphate phospho-hydrolase HCX60_RS21955 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HCX60_RS21960 ENOG4108UGV hypoxanthine phosphoribosyltransferase HCX60_RS21970 ENOG4105EUJ GTP cyclohydrolase i HCX60_RS21980 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HCX60_RS22000 ENOG4105CRK lysyL-tRNA synthetase HCX60_RS22025 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22040 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS22045 ENOG41082SX arsR family transcriptional regulator HCX60_RS22060 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HCX60_RS22065 ENOG4108IYU L-aspartate oxidase HCX60_RS22075 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HCX60_RS22125 ENOG4105DR5 peptidase HCX60_RS22130 ENOG4108IG5 Transcriptional regulator HCX60_RS22140 ENOG4108FKE two-component system sensor kinase HCX60_RS22145 ENOG4108PYU two-component system response regulator HCX60_RS22150 ENOG41075QH Lipoprotein CseA HCX60_RS22160 ENOG4105CEN a g-specific adenine glycosylase HCX60_RS22170 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HCX60_RS22190 ENOG4108JWX HCX60_RS22195 ENOG4107R33 ppx gppa phosphatase HCX60_RS22200 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HCX60_RS22205 ENOG4105PF9 Transcriptional regulator HCX60_RS22210 ENOG4105C01 Dihydroxy-acid dehydratase HCX60_RS22220 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HCX60_RS22235 ENOG4105CJ1 ABC, transporter HCX60_RS22245 ENOG4105II7 pyrroline-5-carboxylate reductase HCX60_RS22255 ENOG4105ECQ AraC Family Transcriptional Regulator HCX60_RS22260 ENOG4105C31 Tryptophanyl-tRNA synthetase HCX60_RS22280 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HCX60_RS22295 ENOG4105DGU Histone deacetylase HCX60_RS22300 ENOG4108XFF HCX60_RS22345 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HCX60_RS22350 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HCX60_RS22355 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HCX60_RS22360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HCX60_RS22370 ENOG4105D52 delta-aminolevulinic acid dehydratase HCX60_RS22395 ENOG4105C75 arginyL-tRNA synthetase HCX60_RS22400 ENOG4105DK7 lysyl-tRNA synthetase HCX60_RS22420 ENOG4105E0Y RtcB Protein HCX60_RS22450 ENOG4108PJD permease HCX60_RS22460 ENOG4105KVH Transcriptional regulator HCX60_RS22470 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HCX60_RS22475 ENOG4108UZX fmn reductase HCX60_RS22485 ENOG41062D9 Histidine kinase HCX60_RS22490 ENOG4107S4Y M20 DapE family protein YgeY HCX60_RS22510 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS22575 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HCX60_RS22580 ENOG4108RH7 phosphoglycerate mutase HCX60_RS22590 ENOG4107ZT5 Thiol disulfide interchange protein HCX60_RS22595 ENOG4107QIV Cytochrome c biogenesis protein HCX60_RS22600 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HCX60_RS22605 ENOG4105CRE cytochrome C HCX60_RS22630 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HCX60_RS22635 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HCX60_RS22640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HCX60_RS22650 ENOG4105DVY radical SAM domain protein HCX60_RS22665 ENOG4108R86 Transcriptional regulator HCX60_RS22675 ENOG4105CHR reductase HCX60_RS22680 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS22755 ENOG4105ZXU NLP P60 protein HCX60_RS22825 ENOG4105DXX methyltransferase HCX60_RS22845 ENOG4105VEQ Cold shock protein HCX60_RS22850 ENOG4105EV6 Pfam:DUF178 HCX60_RS22855 ENOG4108762 serine threonine protein kinase HCX60_RS22865 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HCX60_RS22895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS22915 ENOG41068JE domain protein HCX60_RS22925 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22930 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HCX60_RS22935 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22945 ENOG4107QIZ NADH dehydrogenase HCX60_RS22950 ENOG4108IEH NADH dehydrogenase subunit g HCX60_RS22955 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HCX60_RS22960 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22965 ENOG41087XN oxidoreductase HCX60_RS22970 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22975 ENOG4105D65 subunit l HCX60_RS22985 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS22990 ENOG4105C9U ATP-dependent DNA helicase RecQ HCX60_RS22995 ENOG4108IYU L-aspartate oxidase HCX60_RS23005 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HCX60_RS23020 ENOG4105FDP GntR family transcriptional regulator HCX60_RS23030 ENOG4105ERH Fumarylacetoacetate hydrolase HCX60_RS23060 ENOG4107BJW polysaccharide deacetylase HCX60_RS23075 ENOG410667J hydrolase HCX60_RS23095 ENOG4105CJ1 ABC, transporter HCX60_RS23135 ENOG4105ECR NmrA family HCX60_RS23140 ENOG4105KVH Transcriptional regulator HCX60_RS23145 ENOG4105DQU oxidoreductase, subunit beta HCX60_RS23150 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HCX60_RS23170 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HCX60_RS23175 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS23180 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HCX60_RS23185 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HCX60_RS23190 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS23195 ENOG4107YX3 NADH dehydrogenase subunit j HCX60_RS23200 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS23210 ENOG4105C8S subunit m HCX60_RS23215 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HCX60_RS23220 ENOG4105D0M Protease HtpX homolog HCX60_RS23225 ENOG410901E Membrane HCX60_RS23240 ENOG4105Y3U Transglycosylase-associated protein HCX60_RS23245 ENOG4108VPT UPF0234 protein HCX60_RS23275 ENOG4107RHI Cytosine-specific methyltransferase HCX60_RS23305 ENOG4105CNU cell division protein FtsK HCX60_RS23380 ENOG4105DZC cytosine deaminase HCX60_RS23395 ENOG4105WDJ 50S ribosomal protein L33 HCX60_RS23400 ENOG410900P UPF0336 protein HCX60_RS23420 ENOG4107R4N Cell wall formation (By similarity) HCX60_RS23425 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HCX60_RS23445 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HCX60_RS23455 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HCX60_RS23465 ENOG4108VZM 50s ribosomal protein L10 HCX60_RS23470 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HCX60_RS23475 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCX60_RS23480 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCX60_RS23500 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HCX60_RS23505 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HCX60_RS23510 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HCX60_RS23545 ENOG4105D82 Glutamate dehydrogenase HCX60_RS23555 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HCX60_RS23560 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HCX60_RS23565 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HCX60_RS23570 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HCX60_RS23575 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HCX60_RS23580 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HCX60_RS23585 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HCX60_RS23590 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HCX60_RS23595 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HCX60_RS23600 ENOG41082SA 50s ribosomal protein l29 HCX60_RS23605 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HCX60_RS23610 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HCX60_RS23615 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HCX60_RS23620 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HCX60_RS23625 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HCX60_RS23630 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HCX60_RS23635 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HCX60_RS23640 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HCX60_RS23645 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HCX60_RS23650 ENOG410849U 50S ribosomal protein L30 HCX60_RS23655 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HCX60_RS23660 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HCX60_RS23665 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HCX60_RS23680 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HCX60_RS23685 ENOG41067V7 50S ribosomal protein L36 HCX60_RS23690 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HCX60_RS23695 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HCX60_RS23700 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HCX60_RS23705 ENOG4108ZT0 50S ribosomal protein l17 HCX60_RS23710 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HCX60_RS23725 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HCX60_RS23730 ENOG4108UJD 30S ribosomal protein S9 HCX60_RS23735 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HCX60_RS23740 ENOG4105CS9 pantothenic acid kinase HCX60_RS23745 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HCX60_RS23760 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HCX60_RS23770 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HCX60_RS23775 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS23780 ENOG4108097 ATP-binding protein HCX60_RS23805 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HCX60_RS23825 ENOG4108KGH TRANSCRIPTIONal HCX60_RS23835 ENOG4105CHP RNA polymerase HCX60_RS23855 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HCX60_RS23860 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HCX60_RS23880 ENOG4105EMU Dehydrogenase HCX60_RS23890 ENOG4105DND Transcriptional regulator HCX60_RS23895 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS23905 ENOG4108MMM RNA Polymerase HCX60_RS23915 ENOG4107QVP Dehydrogenase HCX60_RS23925 ENOG4107QQG Dehydrogenase HCX60_RS23930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HCX60_RS23955 ENOG4107TPY serine threonine protein kinase HCX60_RS23960 ENOG4108UGD Serine Threonine protein kinase HCX60_RS23965 ENOG4107TPY serine threonine protein kinase HCX60_RS23970 ENOG4105C26 Dehydrogenase HCX60_RS23985 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HCX60_RS24045 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS24095 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HCX60_RS24105 ENOG4105DEG Vwa containing coxe family protein HCX60_RS24110 ENOG4105CMV Succinyl-CoA synthetase subunit beta HCX60_RS24130 ENOG4108KPJ rna polymerase sigma factor HCX60_RS24145 ENOG4105DC1 bifunctional purine biosynthesis protein purh HCX60_RS24170 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HCX60_RS24185 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HCX60_RS24190 ENOG4105C57 major facilitator superfamily HCX60_RS24210 ENOG4108IJ7 Glycine betaine HCX60_RS24215 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component HCX60_RS24225 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HCX60_RS24240 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HCX60_RS24245 ENOG4105C31 Tryptophanyl-tRNA synthetase HCX60_RS24280 ENOG4107H3J ribonuclease HCX60_RS24295 ENOG4107RN3 metallophosphoesterase HCX60_RS24300 ENOG41067SE Tetr family transcriptional regulator HCX60_RS24340 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HCX60_RS24360 ENOG4105E2D ec 3.2.1.52 HCX60_RS24370 ENOG4108MMM RNA Polymerase HCX60_RS24400 ENOG4108NIW Leucine export protein LeuE HCX60_RS24445 ENOG4105CKK Glycosyl transferase, family 2 HCX60_RS24455 ENOG4105K64 Glycosyl transferase, family 2 HCX60_RS24465 ENOG4105F0R Cytidylyltransferase HCX60_RS24470 ENOG4105D2T synthase HCX60_RS24500 ENOG4107RM1 amidohydrolase HCX60_RS24505 ENOG4105DIH basic membrane HCX60_RS24510 ENOG4105DIH basic membrane HCX60_RS24515 ENOG4108JQ9 ABC transporter HCX60_RS24555 ENOG4105D94 Major Facilitator Superfamily HCX60_RS24560 ENOG4107RSM transcriptional regulator HCX60_RS24570 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HCX60_RS24595 ENOG41065SU Two-component system sensor kinase HCX60_RS24600 ENOG4108KXV response regulator HCX60_RS24605 ENOG4105NAF rna polymerase sigma factor HCX60_RS24620 ENOG4105C26 Dehydrogenase HCX60_RS24625 ENOG4105C26 Dehydrogenase HCX60_RS24645 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HCX60_RS24675 ENOG4108JIK carboxylase HCX60_RS24685 ENOG4107WR6 Maf-like protein HCX60_RS24695 ENOG4105D8K carboxyl transferase HCX60_RS24705 ENOG4108QER Adenylate cyclase HCX60_RS24715 ENOG4105E39 Enoyl-CoA hydratase HCX60_RS24720 ENOG4105KDM Diguanylate cyclase with gaf sensor HCX60_RS24725 ENOG4105C84 Histidine ammonia-lyase HCX60_RS24755 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HCX60_RS24765 ENOG4105DQ4 alcohol dehydrogenase HCX60_RS24795 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HCX60_RS24815 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HCX60_RS24820 ENOG4105C7B Threonine dehydratase HCX60_RS24835 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HCX60_RS24845 ENOG4105T1M mycothiol conjugate amidase mca HCX60_RS24860 ENOG4105C7Z Conserved Protein HCX60_RS24895 ENOG4105C57 major facilitator superfamily HCX60_RS24905 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HCX60_RS24920 ENOG4105CHM Aminotransferase HCX60_RS24945 ENOG4108FUF Transcriptional regulator, IclR family HCX60_RS24950 ENOG4105KME endoribonuclease L-psp HCX60_RS25060 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS25080 ENOG4107QKZ Ompa motb domain protein HCX60_RS25095 ENOG4105NAE bifunctional deaminase-reductase domain protein HCX60_RS25125 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HCX60_RS25130 ENOG4108IAB Phoh family HCX60_RS25135 ENOG4106770 Is able to cleave peptidoglycan (By similarity) HCX60_RS25150 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HCX60_RS25155 ENOG4105D3R alkyl hydroperoxide reductase HCX60_RS25185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HCX60_RS25205 ENOG4105BZ4 penicillin-binding protein HCX60_RS25220 ENOG4105C9Q fumarate hydratase class II HCX60_RS25225 ENOG4107GFK fumarate HCX60_RS25235 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS25250 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HCX60_RS25255 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCX60_RS25260 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HCX60_RS25265 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HCX60_RS25280 ENOG4105C3G gtp-binding protein HCX60_RS25310 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HCX60_RS25315 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS25320 ENOG4105BZU Histidine kinase HCX60_RS25325 ENOG4108JGH Tetr family transcriptional regulator HCX60_RS25330 ENOG4105EYF MMPL domain protein HCX60_RS25340 ENOG4105C4M (Ubiquinol oxidase) subunit I HCX60_RS25400 ENOG4105E33 succinate dehydrogenase HCX60_RS25405 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HCX60_RS25425 ENOG4105CI3 gtp-binding protein typa HCX60_RS25430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS25450 ENOG4108JQ7 (ABC) transporter HCX60_RS25455 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCX60_RS25465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCX60_RS25470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS25475 ENOG4105C3U ABC transporter HCX60_RS25480 ENOG4108JQ7 (ABC) transporter HCX60_RS25510 ENOG4108M15 ABC transporter HCX60_RS25520 ENOG4108ZGX Histidine kinase HCX60_RS25525 ENOG4108S01 response regulator HCX60_RS25540 ENOG4108Z4U Ferredoxin HCX60_RS25560 ENOG4107R4C succinyl-diaminopimelate desuccinylase HCX60_RS25565 ENOG4108URH decarboxylase HCX60_RS25570 ENOG4105EEI dihydropteroate synthase HCX60_RS25580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HCX60_RS25585 ENOG4105CGU Enoyl-CoA hydratase HCX60_RS25600 ENOG4105DU6 RNA polymerase HCX60_RS25610 ENOG4105C0H protease HCX60_RS25615 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HCX60_RS25650 ENOG4105D7N magnesium and cobalt transport protein CorA HCX60_RS25660 ENOG4105DXB Major Facilitator superfamily HCX60_RS25675 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HCX60_RS25695 ENOG4105C1J atp-dependent rna helicase HCX60_RS25765 ENOG4106JDR secreted HCX60_RS25770 ENOG4106JDR secreted HCX60_RS25795 ENOG4105C4R Atp-dependent dna helicase HCX60_RS25800 ENOG4107QSE Dipeptidase HCX60_RS25805 ENOG4105E09 nadh pyrophosphatase HCX60_RS25825 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS25895 ENOG41063PX domain protein HCX60_RS25905 ENOG4105DJZ UPF0182 protein HCX60_RS25935 ENOG4107TK4 histidinol-phosphate phosphatase HCX60_RS25950 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HCX60_RS25955 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HCX60_RS25965 ENOG4108RAV Conserved protein HCX60_RS25975 ENOG4105EMN RNA polymerase sigma factor HCX60_RS25980 ENOG4105WMN AntiSigma factor HCX60_RS25985 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCX60_RS26000 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCX60_RS26010 ENOG41068W2 Cytochrome p-450 HCX60_RS26025 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCX60_RS26030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCX60_RS26045 ENOG4105FDP GntR family transcriptional regulator HCX60_RS26065 ENOG4105D17 glycoside hydrolase, family 3 domain protein HCX60_RS26070 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HCX60_RS26085 ENOG4105CBD Diacylglycerol kinase HCX60_RS26115 ENOG4105K6H D-cysteine desulfhydrase HCX60_RS26120 ENOG4105ESN nucleotide-binding protein HCX60_RS26140 ENOG4108VEQ Superoxide dismutase HCX60_RS26155 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCX60_RS26160 ENOG4105CDA abc transporter atp-binding protein HCX60_RS26175 ENOG4105C6K Malic enzyme HCX60_RS26180 ENOG4105CB2 alcohol dehydrogenase HCX60_RS26220 ENOG4105EB3 Histidine kinase HCX60_RS26225 ENOG4108PYU two-component system response regulator HCX60_RS26235 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HCX60_RS26275 ENOG4105ZXU NLP P60 protein HCX60_RS26285 ENOG41060BG Tetr family transcriptional regulator HCX60_RS26310 ENOG4105CJN penicillin-binding protein HCX60_RS26325 ENOG4108FKE two-component system sensor kinase HCX60_RS26345 ENOG4105DQE DNA ligase HCX60_RS26350 ENOG4105FDF Could be involved in DNA repair (By similarity) HCX60_RS26360 ENOG4105C26 Dehydrogenase HCX60_RS26375 ENOG4105D0M Protease HtpX homolog HCX60_RS26385 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HCX60_RS26390 ENOG4105CIH Imidazole acetol-phosphate transaminase HCX60_RS26395 ENOG4105WBD 4-oxalocrotonate tautomerase HCX60_RS26420 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS26425 ENOG4105MC2 DSBA oxidoreductase HCX60_RS26475 ENOG4105CPF Cell wall formation (By similarity) HCX60_RS26485 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HCX60_RS26490 ENOG4105CR4 methylisocitrate lyase HCX60_RS26555 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HCX60_RS26685 ENOG4105C75 arginyL-tRNA synthetase HCX60_RS26685 ENOG4105C75 arginyL-tRNA synthetase HCX60_RS26690 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HCX60_RS26695 ENOG4105D6E homoserine dehydrogenase HCX60_RS26700 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HCX60_RS26705 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HCX60_RS26715 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HCX60_RS26725 ENOG4105VFB Binds the 23S rRNA (By similarity) HCX60_RS26730 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HCX60_RS26735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HCX60_RS26745 ENOG4107ZF2 Phosphatase HCX60_RS26750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HCX60_RS26755 ENOG4105ESV Glycosyl transferase, family 4 HCX60_RS26765 ENOG4105Z3P ATP synthase HCX60_RS26775 ENOG4105ZA1 atp synthase HCX60_RS26780 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HCX60_RS26785 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HCX60_RS26790 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HCX60_RS26795 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HCX60_RS26800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HCX60_RS26805 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HCX60_RS26820 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS26830 ENOG4105IIP Membrane HCX60_RS26850 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HCX60_RS26885 ENOG4105CJ1 ABC, transporter HCX60_RS26900 ENOG4108ZVT methylmalonyl-coA epimerase HCX60_RS26905 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS26925 ENOG41062D9 Histidine kinase HCX60_RS26990 ENOG4105WX6 Membrane HCX60_RS27035 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HCX60_RS27040 ENOG4105C6K Malic enzyme HCX60_RS27045 ENOG4105CTQ phosphohexokinase HCX60_RS27055 ENOG4108MRH transcriptional regulatory protein HCX60_RS27060 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HCX60_RS27065 ENOG4107QJT sodium dicarboxylate symporter HCX60_RS27070 ENOG4107S5I aldo keto reductase HCX60_RS27090 ENOG4105K63 Thioredoxin HCX60_RS27100 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HCX60_RS27105 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HCX60_RS27110 ENOG4105CG3 alpha amylase, catalytic region HCX60_RS27115 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HCX60_RS27120 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS27125 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HCX60_RS27150 ENOG4105BZ1 (ABC) transporter HCX60_RS27155 ENOG4105BZ1 (ABC) transporter HCX60_RS27165 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HCX60_RS27170 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HCX60_RS27205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HCX60_RS27210 ENOG4105E6M Sulphatase-modifying factor protein HCX60_RS27220 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HCX60_RS27225 ENOG4105EJQ L-serine dehydratase HCX60_RS27230 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HCX60_RS27235 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HCX60_RS27240 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HCX60_RS27280 ENOG4108JQ7 (ABC) transporter HCX60_RS27285 ENOG4105EN6 Membrane HCX60_RS27315 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HCX60_RS27320 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HCX60_RS27340 ENOG4105EMU Dehydrogenase HCX60_RS27350 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HCX60_RS27360 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HCX60_RS27365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HCX60_RS27375 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HCX60_RS27385 ENOG4105EYF MMPL domain protein HCX60_RS27390 ENOG4105D9U N-acetyltransferase HCX60_RS27405 ENOG4107SM8 Adenylate Guanylate cyclase HCX60_RS27415 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HCX60_RS27420 ENOG4106F59 XRE family Transcriptional regulator HCX60_RS27425 ENOG4108FN7 Aldo keto reductase HCX60_RS27450 ENOG4108ZP8 Acetolactate synthase small subunit HCX60_RS27455 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HCX60_RS27465 ENOG4105C57 major facilitator superfamily HCX60_RS27480 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HCX60_RS27490 ENOG4105C26 Dehydrogenase HCX60_RS27495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HCX60_RS27500 ENOG4105CM2 brancheD-chain amino acid aminotransferase HCX60_RS27515 ENOG4105CQM Urea amidohydrolase subunit alpha HCX60_RS27520 ENOG4105DWY Agmatine deiminase HCX60_RS27530 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HCX60_RS27570 ENOG4105D8K carboxyl transferase HCX60_RS27590 ENOG4105GWZ Roadblock lc7 family protein HCX60_RS27610 ENOG4105GWZ Roadblock lc7 family protein HCX60_RS27625 ENOG4105ERH Fumarylacetoacetate hydrolase HCX60_RS27630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HCX60_RS27675 ENOG41069M3 Transcriptional regulator HCX60_RS27680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HCX60_RS27685 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HCX60_RS27695 ENOG4105K70 DNA-binding protein HCX60_RS27715 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HCX60_RS27720 ENOG4105CPF Cell wall formation (By similarity) HCX60_RS27740 ENOG4105DWF phosphomethylpyrimidine kinase HCX60_RS27745 ENOG4105VB9 50S ribosomal protein l28 HCX60_RS27750 ENOG4105DP4 dak2 domain fusion protein ylov HCX60_RS27765 ENOG4105CB5 ATP-dependent DNA helicase recG HCX60_RS27770 ENOG4106H78 methyltransferase HCX60_RS27775 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HCX60_RS27790 ENOG41084BZ 50S ribosomal protein L32 HCX60_RS27795 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HCX60_RS27800 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HCX60_RS27805 ENOG4105KVH Transcriptional regulator HCX60_RS27810 ENOG4105K4I Scp-like extracellular HCX60_RS27815 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HCX60_RS27875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HCX60_RS27885 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HCX60_RS27895 ENOG4105K5M 30s ribosomal protein S16 HCX60_RS27900 ENOG41082KU UPF0109 protein HCX60_RS27905 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HCX60_RS27910 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HCX60_RS27915 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HCX60_RS27930 ENOG4107QYR Signal peptidase i HCX60_RS27935 ENOG4107QYR Signal peptidase i HCX60_RS27950 ENOG41080R2 UPF0102 protein HCX60_RS27965 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS27980 ENOG4105CE9 30S ribosomal protein S2 HCX60_RS27985 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HCX60_RS27990 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HCX60_RS27995 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HCX60_RS28000 ENOG4105KNE Phosphatidate cytidylyltransferase HCX60_RS28095 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HCX60_RS28105 ENOG4108I5D sulfate abc transporter HCX60_RS28110 ENOG4108UCS ABC, transporter HCX60_RS28130 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HCX60_RS28135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HCX60_RS28145 ENOG4105C26 Dehydrogenase HCX60_RS28205 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HCX60_RS28210 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HCX60_RS28235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HCX60_RS28240 ENOG4105F38 ABC transporter, permease HCX60_RS28245 ENOG4105D38 putrescine abc transporter HCX60_RS28250 ENOG4105CJP fad dependent oxidoreductase HCX60_RS28260 ENOG4105G9B Transcriptional regulator HCX60_RS28280 ENOG4105C26 Dehydrogenase HCX60_RS28285 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HCX60_RS28300 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HCX60_RS28340 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HCX60_RS28345 ENOG4105DZP Membrane-associated zinc metalloprotease HCX60_RS28350 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HCX60_RS28365 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HCX60_RS28400 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HCX60_RS28420 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HCX60_RS28445 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HCX60_RS28450 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HCX60_RS28480 ENOG4108T50 Protein of unknown function (DUF690) HCX60_RS28485 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS28540 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS28570 ENOG4105EC2 ftsk spoIIIe HCX60_RS28590 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HCX60_RS28595 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HCX60_RS28600 ENOG4105C1V Peptidase, M16 HCX60_RS28605 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HCX60_RS28625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCX60_RS28630 ENOG4105CN5 Metallo-Beta-Lactamase HCX60_RS28670 ENOG4105BZU Histidine kinase HCX60_RS28675 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HCX60_RS28690 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HCX60_RS28700 ENOG4105CEV competence damage-inducible protein HCX60_RS28705 ENOG4105WBV Transcriptional regulator HCX60_RS28715 ENOG4105CHR reductase HCX60_RS28720 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HCX60_RS28725 ENOG4107QRT dEAD DEAH box helicase HCX60_RS28730 ENOG4106AXJ AraC family transcriptional regulator HCX60_RS28765 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HCX60_RS28775 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HCX60_RS28785 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HCX60_RS28790 ENOG4105DRP amino acid AbC transporter HCX60_RS28795 ENOG4108Q1T ABC transporter HCX60_RS28800 ENOG4107UBR Extracellular solute-binding protein family 3 HCX60_RS28805 ENOG4105CDA abc transporter atp-binding protein HCX60_RS28810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS28815 ENOG4105EB3 Histidine kinase HCX60_RS28850 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS28855 ENOG4105CHM Aminotransferase HCX60_RS28875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HCX60_RS28895 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HCX60_RS28905 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HCX60_RS28925 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HCX60_RS28955 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HCX60_RS28960 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HCX60_RS28965 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HCX60_RS28980 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HCX60_RS28990 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HCX60_RS29005 ENOG4105C9U ATP-dependent DNA helicase RecQ HCX60_RS29025 ENOG4108M15 ABC transporter HCX60_RS29030 ENOG4105C6F GntR Family Transcriptional Regulator HCX60_RS29035 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HCX60_RS29040 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HCX60_RS29050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCX60_RS29065 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS29075 ENOG4107QN1 sodium solute HCX60_RS29080 ENOG4108V9W transcriptional regulatory protein HCX60_RS29085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HCX60_RS29095 ENOG4105BZN citrate synthase HCX60_RS29110 ENOG4105CKI cobalamin synthesis protein HCX60_RS29115 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HCX60_RS29135 ENOG4105DRR Transcriptional regulator, GntR family HCX60_RS29140 ENOG410849S phosphocarrier protein (HPr) HCX60_RS29150 ENOG4105CD5 CoA-binding domain protein HCX60_RS29170 ENOG4107W53 thymidine kinase HCX60_RS29190 ENOG4105KHC sulfurtransferase HCX60_RS29210 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HCX60_RS29225 ENOG4105F44 Two component transcriptional regulator, winged helix family HCX60_RS29230 ENOG4106F60 Histidine kinase HCX60_RS29255 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HCX60_RS29290 ENOG4107VEG TrkA-N domain protein HCX60_RS29295 ENOG4105C0X amino acid HCX60_RS29300 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HCX60_RS29395 ENOG4108IPT Naphthoate synthase HCX60_RS29445 ENOG4107R11 Transcriptional regulator HCX60_RS29450 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HCX60_RS29455 ENOG4108W6C Dehydrogenase HCX60_RS29470 ENOG4107S1Q Phosphatase HCX60_RS29485 ENOG4105CEU Arginine dihydrolase HCX60_RS29490 ENOG4105DBV ornithine carbamoyltransferase HCX60_RS29500 ENOG4105CGU Enoyl-CoA hydratase HCX60_RS29545 ENOG4105CFG Acts as a chaperone (By similarity) HCX60_RS29610 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HCX60_RS29620 ENOG4107QM5 aconitate hydratase HCX60_RS29640 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HCX60_RS29650 ENOG4105E2R ROK family HCX60_RS29655 ENOG4105DFW ABC transporter HCX60_RS29660 ENOG4105C2J ABC transporter HCX60_RS29665 ENOG4108HWW ABC transporter HCX60_RS29670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HCX60_RS29675 ENOG4105CUB amino acid HCX60_RS29690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCX60_RS29695 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS29700 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HCX60_RS29715 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HCX60_RS29745 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HCX60_RS29760 ENOG4107JTW chlorite dismutase HCX60_RS29780 ENOG4105E18 UPF0276 protein HCX60_RS29815 ENOG4107B2H carbonic anhydrase HCX60_RS29840 ENOG4105DFU Cell wall formation (By similarity) HCX60_RS29845 ENOG4105E0X reductase HCX60_RS29855 ENOG4105BZU Histidine kinase HCX60_RS29860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS29875 ENOG4108IJ8 ABC transporter HCX60_RS29880 ENOG4105E90 ABC transporter HCX60_RS29885 ENOG4105E90 ABC transporter HCX60_RS29900 ENOG4105GWZ Roadblock lc7 family protein HCX60_RS29915 ENOG4105C84 Histidine ammonia-lyase HCX60_RS29930 ENOG4105DHQ Histidine kinase HCX60_RS29965 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS29970 ENOG41064MX Tetr family transcriptional regulator HCX60_RS29980 ENOG4108IND Tetr family transcriptional regulator HCX60_RS29990 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HCX60_RS30000 ENOG4105C0H protease HCX60_RS30115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HCX60_RS30150 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HCX60_RS30175 ENOG4107RR1 TRANSCRIPTIONal HCX60_RS30180 ENOG4105CSU acyl-Coa dehydrogenase HCX60_RS30195 ENOG4105E7U AraC family transcriptional regulator HCX60_RS30255 ENOG4105CR4 methylisocitrate lyase HCX60_RS30260 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS30265 ENOG4108JQ1 Dehydrogenase HCX60_RS30275 ENOG4108J5H Homocysteine s-methyltransferase HCX60_RS30285 ENOG4107TDE lipolytic protein G-D-S-L family HCX60_RS30350 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HCX60_RS30370 ENOG4105QE3 oxidoreductase HCX60_RS30380 ENOG4106R7G Glycoside hydrolase family 5 HCX60_RS30385 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HCX60_RS30395 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HCX60_RS30415 ENOG4105C7K acetolactate synthase HCX60_RS30445 ENOG4105DRR Transcriptional regulator, GntR family HCX60_RS30470 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HCX60_RS30475 ENOG4105C7N Xanthine uracil vitamin C permease HCX60_RS30495 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HCX60_RS30505 ENOG4108JJB ABC transporter HCX60_RS30510 ENOG4108V4M Cobalt abc transporter HCX60_RS30520 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HCX60_RS30525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HCX60_RS30535 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HCX60_RS30555 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS30565 ENOG41060W2 glyoxylate carboligase HCX60_RS30605 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HCX60_RS30610 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HCX60_RS30630 ENOG4105VT2 5-hydroxyisourate hydrolase HCX60_RS30640 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HCX60_RS30650 ENOG4105KVH Transcriptional regulator HCX60_RS30665 ENOG4108ZM9 phosphoglycerate mutase HCX60_RS30670 ENOG4105CHM Aminotransferase HCX60_RS30690 ENOG4105DUU IucA IucC family protein HCX60_RS30715 ENOG4107R9S Malate synthase HCX60_RS30730 ENOG4107HP6 Transcriptional regulator HCX60_RS30765 ENOG4107TPY serine threonine protein kinase HCX60_RS30795 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HCX60_RS30825 ENOG4105CQF Transcriptional regulator HCX60_RS30840 ENOG4105BZU Histidine kinase HCX60_RS30860 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS30865 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HCX60_RS30875 ENOG4105DKQ ROK family HCX60_RS30905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HCX60_RS30965 ENOG4108IUE nitrate reductase beta subunit HCX60_RS30985 ENOG4105CEI nitrite reductase HCX60_RS31020 ENOG4108IUE nitrate reductase beta subunit HCX60_RS31025 ENOG4105R3A Nitrate reductase HCX60_RS31045 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HCX60_RS31050 ENOG4105E8R UPF0173 metal-dependent hydrolase HCX60_RS31075 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HCX60_RS31080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCX60_RS31105 ENOG4105C8Y Acetylornithine aminotransferase HCX60_RS31120 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HCX60_RS31130 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HCX60_RS31140 ENOG4105ECY inositol monophosphatase HCX60_RS31155 ENOG4105EMN RNA polymerase sigma factor HCX60_RS31180 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS31185 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HCX60_RS31190 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HCX60_RS31195 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HCX60_RS31200 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HCX60_RS31205 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HCX60_RS31210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HCX60_RS31215 ENOG4105CHR reductase HCX60_RS31220 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HCX60_RS31230 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HCX60_RS31240 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCX60_RS31275 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HCX60_RS31285 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HCX60_RS31295 ENOG4105BZW Glycerate kinase HCX60_RS31305 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HCX60_RS31310 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS31340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCX60_RS31360 ENOG4106JDR secreted HCX60_RS31400 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HCX60_RS31405 ENOG4108ME1 Peptidase M55 D-aminopeptidase HCX60_RS31410 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HCX60_RS31420 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HCX60_RS31430 ENOG4105D9U N-acetyltransferase HCX60_RS31460 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS31470 ENOG4105C5H ABC transporter HCX60_RS31560 ENOG410842T Pterin carbinolamine dehydratase HCX60_RS31565 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS31580 ENOG4105D29 Helix-turn-helix type 11 domain protein HCX60_RS31585 ENOG41065HY 1,4-beta-cellobiosidase HCX60_RS31595 ENOG4105CV8 reductase HCX60_RS31605 ENOG4105DUM transcriptional regulator, lysR family HCX60_RS31615 ENOG4105D3W isochorismatase HCX60_RS31620 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HCX60_RS31635 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HCX60_RS31640 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HCX60_RS31655 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HCX60_RS31665 ENOG4105FCD Major Facilitator HCX60_RS31685 ENOG4105CMV Succinyl-CoA synthetase subunit beta HCX60_RS31695 ENOG4105C26 Dehydrogenase HCX60_RS31725 ENOG4106A3M Cytochrome p-450 HCX60_RS31735 ENOG4105F95 Monooxygenase HCX60_RS31745 ENOG4105CTU Proline racemase HCX60_RS31750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HCX60_RS31765 ENOG4105MWK D-amino acid dehydrogenase, small subunit HCX60_RS31775 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HCX60_RS31780 ENOG4105EGE secreted protein HCX60_RS31795 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HCX60_RS31805 ENOG4108RZ2 Glycoside hydrolase family 16 HCX60_RS31845 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCX60_RS31860 ENOG4107QJN gtp cyclohydrolase ii HCX60_RS31895 ENOG410905P Pyridoxamine 5-phosphate HCX60_RS31915 ENOG4108J5G 6-phosphogluconate dehydrogenase HCX60_RS31920 ENOG4107QP8 phosphohexose isomerase HCX60_RS31935 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HCX60_RS31955 ENOG4105F8D glycoside hydrolase family 4 HCX60_RS32070 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HCX60_RS32185 ENOG4105CNU cell division protein FtsK HCX60_RS32370 ENOG4105C1B dTDP-glucose 4-6-dehydratase HCX60_RS32405 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HCX60_RS32485 ENOG4106UDK Cellulose-binding, family II HCX60_RS32550 ENOG4105ECR NmrA family HCX60_RS32590 ENOG4108IAJ Nad-dependent epimerase dehydratase HCX60_RS32600 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCX60_RS32650 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HCX60_RS32655 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HCX60_RS32660 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HCX60_RS32685 ENOG41067TZ transcriptional regulator, MarR family HCX60_RS32705 ENOG4105DQE DNA ligase HCX60_RS32720 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HCX60_RS32730 ENOG4106V2I dimethylaminohydrolase HCX60_RS32735 ENOG4105C5H ABC transporter HCX60_RS32760 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HCX60_RS32765 ENOG4105EG6 Saccharopine dehydrogenase HCX60_RS32780 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS32785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCX60_RS32790 ENOG4108Z4X TRANSCRIPTIONal HCX60_RS32795 ENOG4108U3T pfkb domain protein HCX60_RS32815 ENOG4105C5H ABC transporter HCX60_RS32820 ENOG4105BZM domain protein HCX60_RS32825 ENOG4105E39 Enoyl-CoA hydratase HCX60_RS32835 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HCX60_RS32860 ENOG4108MDK Dehydrogenase HCX60_RS32880 ENOG4105EY8 ABC transporter HCX60_RS32885 ENOG4105FBD synthase HCX60_RS32895 ENOG4107S11 squalene-associated FAD-dependent desaturase HCX60_RS32905 ENOG4105EWU Squalene--hopene cyclase HCX60_RS32920 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HCX60_RS32960 ENOG41090WU lipolytic protein G-D-S-L family HCX60_RS33010 ENOG4105CPQ Dehydrogenase HCX60_RS33015 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HCX60_RS33020 ENOG4106NZI LysR family Transcriptional regulator HCX60_RS33065 ENOG4105C5F glutamine synthetase HCX60_RS33070 ENOG4108HCJ Hydrolase HCX60_RS33085 ENOG4105E8V Alpha Beta Hydrolase Fold protein HCX60_RS33095 ENOG4105DAE Methylenetetrahydrofolate reductase HCX60_RS33125 ENOG4105C1G acyl-Coa dehydrogenase HCX60_RS33145 ENOG4105CNN ABC, transporter HCX60_RS33150 ENOG4105C2J ABC transporter HCX60_RS33160 ENOG4105CHR reductase HCX60_RS33170 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS33210 ENOG4107EEY synthase HCX60_RS33235 ENOG4105DE4 1-phosphofructokinase HCX60_RS33250 ENOG4105CDA abc transporter atp-binding protein HCX60_RS33275 ENOG4105DEN Luciferase family HCX60_RS33285 ENOG4106S2D Transcriptional regulator HCX60_RS33295 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HCX60_RS33320 ENOG4105DWV Homoserine O-trans-acetylase HCX60_RS33330 ENOG4105E9K Isocitrate dehydrogenase HCX60_RS33340 ENOG4105D64 Mechanosensitive ion channel HCX60_RS33350 ENOG4105BZ1 (ABC) transporter HCX60_RS33360 ENOG4108UAJ Transcriptional regulator HCX60_RS33370 ENOG4108762 serine threonine protein kinase HCX60_RS33390 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HCX60_RS33395 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HCX60_RS33420 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HCX60_RS33455 ENOG4107RN3 metallophosphoesterase HCX60_RS33490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HCX60_RS33505 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HCX60_RS33525 ENOG4107QPH glycogen) synthase HCX60_RS33530 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HCX60_RS33555 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HCX60_RS33620 ENOG4108ZJ4 polysaccharide deacetylase HCX60_RS33660 ENOG4105BZU Histidine kinase HCX60_RS33665 ENOG4105C5Q Transcriptional regulator HCX60_RS33680 ENOG4105E33 succinate dehydrogenase HCX60_RS33690 ENOG4108Z20 Acyl-transferase HCX60_RS33700 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HCX60_RS33705 ENOG4105DEN Luciferase family HCX60_RS33715 ENOG4105WKW Pfam:DUF1458 HCX60_RS33720 ENOG4105D3Q Sugar transferase HCX60_RS33725 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HCX60_RS33730 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HCX60_RS33740 ENOG4108IAJ Nad-dependent epimerase dehydratase HCX60_RS33780 ENOG4108N5B 2-phosphosulfolactate phosphatase HCX60_RS33785 ENOG41067HS methyltransferase HCX60_RS33790 ENOG4108V75 Glutamine amidotransferase HCX60_RS33795 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HCX60_RS33815 ENOG4105DZ6 Band 7 protein HCX60_RS33845 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCX60_RS33865 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HCX60_RS33880 ENOG41060NJ transcriptional regulator HCX60_RS33890 ENOG41080RH Thioredoxin HCX60_RS33900 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HCX60_RS33915 ENOG4105EUB pirin domain protein HCX60_RS33980 ENOG41080R8 Conserved Protein HCX60_RS33990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HCX60_RS33995 ENOG4105DET Rhamnulokinase HCX60_RS34005 ENOG4105C9F isomerase HCX60_RS34010 ENOG4105C2J ABC transporter HCX60_RS34020 ENOG4105F5R ABC transporter HCX60_RS34025 ENOG4105D4B ABC, transporter HCX60_RS34040 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS34070 ENOG4105DDN Pentapeptide repeat-containing protein HCX60_RS34075 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HCX60_RS34080 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HCX60_RS34090 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HCX60_RS34115 ENOG4105DCG PHP domain protein HCX60_RS34135 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HCX60_RS34155 ENOG4105ECQ AraC Family Transcriptional Regulator HCX60_RS34175 ENOG4105CUB amino acid HCX60_RS34200 ENOG4105CHF Glutathione S-transferase HCX60_RS34215 ENOG4105FQP Beta-lactamase HCX60_RS34225 ENOG4105CPC Aldo Keto reductase HCX60_RS34270 ENOG4105DMF Dehydrogenase HCX60_RS34290 ENOG4108JJA ABC, transporter HCX60_RS34295 ENOG4108JJA ABC, transporter HCX60_RS34325 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HCX60_RS34355 ENOG4105XRQ Xanthine dehydrogenase accessory factor HCX60_RS34395 ENOG4105C5X domain protein HCX60_RS34400 ENOG4105CHR reductase HCX60_RS34460 ENOG4105C5F glutamine synthetase HCX60_RS34475 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) HCX60_RS34495 ENOG4108X07 Tetr family transcriptional regulator HCX60_RS34505 ENOG4105C26 Dehydrogenase HCX60_RS34510 ENOG4108Z86 Glutamine amidotransferase HCX60_RS34515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HCX60_RS34520 ENOG4105GVJ transcriptional regulator HCX60_RS34580 ENOG4105EYF MMPL domain protein HCX60_RS34610 ENOG4105G9B Transcriptional regulator HCX60_RS34615 ENOG4108IV0 ABC, transporter HCX60_RS34620 ENOG4105C0Z ABC transporter HCX60_RS34625 ENOG4105C32 Amino acid ABC transporter (Permease) HCX60_RS34640 ENOG4105BZ1 (ABC) transporter HCX60_RS34675 ENOG4105CF7 AraC family transcriptional regulator HCX60_RS34680 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HCX60_RS34700 ENOG4105D74 hydrolase HCX60_RS34725 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HCX60_RS34755 ENOG4105CBD Diacylglycerol kinase HCX60_RS34765 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HCX60_RS34800 ENOG4105DEG Vwa containing coxe family protein HCX60_RS34805 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HCX60_RS34830 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HCX60_RS34870 ENOG4105CSA Coproporphyrinogen iii oxidase HCX60_RS34880 ENOG4105C4C beta-galactosidase HCX60_RS34890 ENOG4105DRS transport system, permease HCX60_RS35005 ENOG4105E0A ABC, transporter HCX60_RS35010 ENOG4105EHG Permease protein HCX60_RS35015 ENOG4105DQ5 transport system permease protein HCX60_RS35020 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS35030 ENOG4108HUF Transporter HCX60_RS35035 ENOG4105BZ1 (ABC) transporter HCX60_RS35040 ENOG4105BZ1 (ABC) transporter HCX60_RS35050 ENOG4107TPS domain protein HCX60_RS35065 ENOG4108762 serine threonine protein kinase HCX60_RS35125 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HCX60_RS35135 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HCX60_RS35155 ENOG4105E0A ABC, transporter HCX60_RS35160 ENOG4105J76 Periplasmic binding protein HCX60_RS35165 ENOG4105S6R Iron-hydroxamate transporter permease subunit HCX60_RS35185 ENOG4105ECQ AraC Family Transcriptional Regulator HCX60_RS35210 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HCX60_RS35220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS35225 ENOG4105C3U ABC transporter HCX60_RS35230 ENOG4108JQ7 (ABC) transporter HCX60_RS35240 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HCX60_RS35275 ENOG4105RNG membrane HCX60_RS35290 ENOG4106UW1 Major Facilitator superfamily HCX60_RS35335 ENOG4106UDK Cellulose-binding, family II HCX60_RS35340 ENOG4105EGE secreted protein HCX60_RS35345 ENOG4105EEM helicase HCX60_RS35355 ENOG4108ZJI phenylacetic acid degradation protein HCX60_RS35360 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS35365 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HCX60_RS35375 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HCX60_RS35380 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HCX60_RS35385 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HCX60_RS35390 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HCX60_RS35395 ENOG4105NQG DoxX HCX60_RS35410 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HCX60_RS35415 ENOG4105DVW rieske (2Fe-2S) HCX60_RS35425 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HCX60_RS35435 ENOG4108IJ7 Glycine betaine HCX60_RS35440 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component HCX60_RS35515 ENOG4105BZ1 (ABC) transporter HCX60_RS35520 ENOG4105BZ1 (ABC) transporter HCX60_RS35530 ENOG4105E0A ABC, transporter HCX60_RS35535 ENOG4108U1V ABC transporter, permease HCX60_RS35540 ENOG4105DQ5 transport system permease protein HCX60_RS35545 ENOG4105EQD regulatoR HCX60_RS35560 ENOG4105C9B Cysteine desulfurase HCX60_RS35565 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS35580 ENOG4105D9P serine threonine protein kinase HCX60_RS35605 ENOG4105EGE secreted protein HCX60_RS35620 ENOG4105C0R drug resistance transporter emrb qaca subfamily HCX60_RS35625 ENOG4105EEX Two component transcriptional regulator (Winged helix family HCX60_RS35630 ENOG4105BZU Histidine kinase HCX60_RS35640 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HCX60_RS35645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HCX60_RS35655 ENOG4105VEQ Cold shock protein HCX60_RS35675 ENOG4107U9T Pfam:Ribonuclease_BN HCX60_RS35705 ENOG4107TE5 Lipid kinase HCX60_RS35715 ENOG4105BZ9 Cytochrome C oxidase, subunit I HCX60_RS35725 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HCX60_RS35735 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HCX60_RS35750 ENOG41081F0 Precorrin-8x methylmutase HCX60_RS35755 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HCX60_RS35760 ENOG4105CTK cobaltochelatase, cobn subunit HCX60_RS35765 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HCX60_RS35775 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HCX60_RS35780 ENOG4108X07 Tetr family transcriptional regulator HCX60_RS35785 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HCX60_RS35790 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HCX60_RS35805 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HCX60_RS35820 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HCX60_RS35825 ENOG41080UQ Transcriptional regulator HCX60_RS35835 ENOG4105E2D ec 3.2.1.52 HCX60_RS35855 ENOG4105FDP GntR family transcriptional regulator HCX60_RS35875 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HCX60_RS35880 ENOG4105CBC glutamate synthase HCX60_RS35895 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HCX60_RS35905 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS35935 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HCX60_RS35940 ENOG4106FTQ Taurine ABC transporter, periplasmic HCX60_RS35945 ENOG4108IY8 ABC, transporter HCX60_RS35950 ENOG4105E2B Taurine dioxygenase HCX60_RS35960 ENOG4108JQ5 ABC transporter HCX60_RS35965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HCX60_RS35970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HCX60_RS35990 ENOG4107S8C mandelate racemase muconate lactonizing HCX60_RS35995 ENOG410880H cysteine synthase HCX60_RS36010 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HCX60_RS36065 ENOG4105D7W serine acetyltransferase HCX60_RS36085 ENOG4105EAB amino acid AbC transporter HCX60_RS36120 ENOG4107QN1 sodium solute HCX60_RS36160 ENOG41066UM arsR family transcriptional regulator HCX60_RS36190 ENOG4105CHH sulfate transporter HCX60_RS36195 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HCX60_RS36220 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HCX60_RS36225 ENOG4105PGM cation diffusion facilitator family transporter HCX60_RS36235 ENOG4105RTX GreA GreB family elongation factor HCX60_RS36290 ENOG4105EZM VWA-like domain (DUF2201) HCX60_RS36335 ENOG4108KEZ Dehydrogenase HCX60_RS36345 ENOG4105ENE Histidine kinase HCX60_RS36350 ENOG4105WH1 Two component transcriptional regulator luxr family HCX60_RS36365 ENOG4105F95 Monooxygenase HCX60_RS36370 ENOG4107Z3H Transcriptional regulator, TetR family HCX60_RS36500 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HCX60_RS36525 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HCX60_RS36530 ENOG4105CD5 CoA-binding domain protein HCX60_RS36540 ENOG4105E2A Dehydrogenase HCX60_RS36550 ENOG4105CCI Myosin-Cross-Reactive Antigen HCX60_RS36555 ENOG4105C0A alcohol dehydrogenase HCX60_RS36560 ENOG4105W87 Cbs domain HCX60_RS36565 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HCX60_RS36570 ENOG4105CJW magnesium transporter HCX60_RS36600 ENOG4107RIQ Sulfate adenylate transferase HCX60_RS36695 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HCX60_RS36710 ENOG4105CJQ hydrolase, family 31 HCX60_RS36730 ENOG4105CWX Alpha-1,2-mannosidase HCX60_RS36735 ENOG4108BAS reductase HCX60_RS36745 ENOG4105G9B Transcriptional regulator HCX60_RS36820 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS36825 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HCX60_RS36860 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HCX60_RS36870 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HCX60_RS36875 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HCX60_RS36880 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HCX60_RS36910 ENOG4108RNG Permease of the drug metabolite transporter HCX60_RS36925 ENOG4108YYC ycei family HCX60_RS36930 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HCX60_RS36950 ENOG4105D9P serine threonine protein kinase HCX60_RS36955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HCX60_RS36990 ENOG4106A3M Cytochrome p-450 HCX60_RS37005 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HCX60_RS37025 ENOG4105CEY Amp-dependent synthetase and ligase HCX60_RS37040 ENOG4105WQT MbtH domain protein HCX60_RS37060 ENOG41082BE ankyrin repeat-containing protein HCX60_RS37065 ENOG410829K Lysine exporter protein (Lyse ygga) HCX60_RS37085 ENOG4105CHR reductase HCX60_RS37095 ENOG4105VMP Transcriptional regulator HCX60_RS37135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HCX60_RS37140 ENOG4108Z6Z Transcriptional regulator HCX60_RS37150 ENOG4105E1F short-chain dehydrogenase reductase HCX60_RS37165 ENOG4107FW0 short-chain dehydrogenase reductase HCX60_RS37180 ENOG41086D8 Transcriptional regulator HCX60_RS37185 ENOG4105CAQ asparagine synthetase HCX60_RS37190 ENOG4105CHU acetyl-coa acetyltransferase HCX60_RS37230 ENOG4105EF7 Transcriptional regulator HCX60_RS37235 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HCX60_RS37250 ENOG4108Z6Z Transcriptional regulator HCX60_RS37285 ENOG4108VGI doxx family HCX60_RS37415 ENOG4105ETE Transcriptional regulator (LacI family HCX60_RS37425 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HCX60_RS37450 ENOG4105CEU Arginine dihydrolase HCX60_RS37455 ENOG4105D5Q Arginine ornithine antiporter HCX60_RS37470 ENOG4105CI2 imidazolone-5-propionate hydrolase HCX60_RS37475 ENOG4108ZJ4 polysaccharide deacetylase HCX60_RS37485 ENOG4105EB3 Histidine kinase HCX60_RS37490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HCX60_RS37530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HCX60_RS37535 ENOG4107QSI ABC, transporter HCX60_RS37545 ENOG4105C3U ABC transporter HCX60_RS37585 ENOG4105BZ1 (ABC) transporter HCX60_RS37595 ENOG4105C26 Dehydrogenase HCX60_RS37620 ENOG4105CFF transcriptional regulator HCX60_RS37630 ENOG4105CR4 methylisocitrate lyase HCX60_RS37655 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HCX60_RS37680 ENOG4105NPE arsR family transcriptional regulator HCX60_RS37690 ENOG4105CKI cobalamin synthesis protein HCX60_RS37695 ENOG41068HZ 50S ribosomal protein L32 HCX60_RS37765 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HCX60_RS37770 ENOG4105BZG amino acid carrier protein HCX60_RS37805 ENOG4105C26 Dehydrogenase HCX60_RS37820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HCX60_RS37825 ENOG4105X7H acyl-CoA dehydrogenase HCX60_RS37830 ENOG4105E39 Enoyl-CoA hydratase HCX60_RS37840 ENOG4105CHH sulfate transporter HCX60_RS37845 ENOG4107TXC Transcriptional regulator HCX60_RS37855 ENOG4105CPQ Dehydrogenase HCX60_RS37865 ENOG4105J7D transcriptional regulator HCX60_RS37870 ENOG4108IXY short-chain dehydrogenase reductase HCX60_RS37895 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HCX60_RS37970 ENOG4105C57 major facilitator superfamily HCX60_RS38000 ENOG4105KVH Transcriptional regulator HCX60_RS38085 ENOG41082YX Transcriptional regulator, arsr family HCX60_RS38100 ENOG4108UXE Protein tyrosine phosphatase HCX60_RS38140 ENOG4105RNG membrane HCX60_RS38145 ENOG4105K6V RNA polymerase HCX60_RS38160 ENOG4105KVH Transcriptional regulator HCX60_RS38165 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)