locus-tag	class	description
HCX60_RS00020	COG0497	DNA recombination
HCX60_RS00240	COG1733	regulation of RNA biosynthetic process
HCX60_RS00265	COG1053	succinate dehydrogenase
HCX60_RS00295	COG1959	2 iron, 2 sulfur cluster binding
HCX60_RS00320	COG0596	Alpha beta hydrolase
HCX60_RS00340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCX60_RS00355	COG1595	DNA-templated transcription, initiation
HCX60_RS00370	COG1053	succinate dehydrogenase
HCX60_RS00390	COG1404	Belongs to the peptidase S8 family
HCX60_RS00415	COG1595	DNA-templated transcription, initiation
HCX60_RS00425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCX60_RS00475	COG0477	Major facilitator Superfamily
HCX60_RS00490	COG0572	uridine kinase
HCX60_RS00530	COG0488	(ABC) transporter
HCX60_RS00540	COG1309	transcriptional regulator
HCX60_RS00550	COG0483	inositol monophosphate 1-phosphatase activity
HCX60_RS00610	COG0583	DNA-binding transcription factor activity
HCX60_RS00620	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCX60_RS00640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCX60_RS00660	COG2226	methyltransferase
HCX60_RS00665	COG1051	belongs to the nudix hydrolase family
HCX60_RS00685	COG0789	Transcriptional regulator
HCX60_RS00690	COG1819	glycosyl
HCX60_RS00720	COG1476	TRANSCRIPTIONal
HCX60_RS00750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS00770	COG4948	Mandelate Racemase Muconate Lactonizing
HCX60_RS00775	COG2362	D-Aminopeptidase
HCX60_RS00785	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCX60_RS00790	COG0454	-acetyltransferase
HCX60_RS00825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS00840	COG1505	serine-type exopeptidase activity
HCX60_RS00845	COG2508	Transcriptional regulator
HCX60_RS00845	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HCX60_RS00850	COG4948	Mandelate Racemase Muconate Lactonizing
HCX60_RS00885	COG0475	glutathione-regulated potassium exporter activity
HCX60_RS00910	COG0789	Transcriptional regulator
HCX60_RS00920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS00930	COG0640	Transcriptional regulator
HCX60_RS00935	COG2226	methyltransferase
HCX60_RS00975	COG2837	iron assimilation
HCX60_RS00985	COG0542	response to heat
HCX60_RS01015	COG1349	DNA-binding transcription factor activity
HCX60_RS01030	COG1523	belongs to the glycosyl hydrolase 13 family
HCX60_RS01035	COG2409	Drug exporters of the RND superfamily
HCX60_RS01065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCX60_RS01070	COG3268	Saccharopine dehydrogenase
HCX60_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS01095	COG1902	pentaerythritol trinitrate reductase activity
HCX60_RS01095	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCX60_RS01105	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS01110	COG1309	transcriptional regulator
HCX60_RS01155	COG1802	Transcriptional regulator
HCX60_RS01175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCX60_RS01180	COG1116	anion transmembrane transporter activity
HCX60_RS01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCX60_RS01205	COG1309	transcriptional regulator
HCX60_RS01210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCX60_RS01225	COG0747	negative chemotaxis
HCX60_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS01245	COG4172	Belongs to the ABC transporter superfamily
HCX60_RS01255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS01270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCX60_RS01305	COG1309	transcriptional regulator
HCX60_RS01335	COG0667	Aldo Keto reductase
HCX60_RS01340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS01365	COG2814	Major facilitator Superfamily
HCX60_RS01395	COG0473	3-isopropylmalate dehydrogenase activity
HCX60_RS01400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCX60_RS01415	COG3842	ATPase activity
HCX60_RS01440	COG1309	transcriptional regulator
HCX60_RS01445	COG2080	2 iron, 2 sulfur cluster binding
HCX60_RS01450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HCX60_RS01455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCX60_RS01465	COG0667	Aldo Keto reductase
HCX60_RS01485	COG0395	ABC-type sugar transport system, permease component
HCX60_RS01500	COG1349	DNA-binding transcription factor activity
HCX60_RS01505	COG0628	permease
HCX60_RS01525	COG0513	Belongs to the DEAD box helicase family
HCX60_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS01550	COG1132	(ABC) transporter
HCX60_RS01555	COG1132	(ABC) transporter
HCX60_RS01565	COG0515	serine threonine protein kinase
HCX60_RS01595	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCX60_RS01635	COG0477	Major facilitator Superfamily
HCX60_RS01640	COG2130	NADP-dependent
HCX60_RS01655	COG0366	Alpha amylase catalytic
HCX60_RS01660	COG0395	ABC-type sugar transport system, permease component
HCX60_RS01665	COG1175	transmembrane transport
HCX60_RS01690	COG3537	Alpha-1,2-mannosidase
HCX60_RS01720	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS01725	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS01730	COG1129	ABC transporter
HCX60_RS01735	COG1879	ABC-type sugar transport system periplasmic component
HCX60_RS01740	COG1609	Transcriptional regulator
HCX60_RS01745	COG3387	PFAM Glycoside hydrolase 15-related
HCX60_RS01750	COG0477	Major facilitator Superfamily
HCX60_RS01755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCX60_RS01775	COG0515	serine threonine protein kinase
HCX60_RS01785	COG0589	response to stress
HCX60_RS01825	COG1309	transcriptional regulator
HCX60_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS01850	COG0443	Heat shock 70 kDa protein
HCX60_RS01895	COG1063	alcohol dehydrogenase
HCX60_RS01900	COG0517	IMP dehydrogenase activity
HCX60_RS01900	COG0516	GMP reductase activity
HCX60_RS01925	COG3835	regulator
HCX60_RS01935	COG2080	2 iron, 2 sulfur cluster binding
HCX60_RS01935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCX60_RS01955	COG0519	Catalyzes the synthesis of GMP from XMP
HCX60_RS01955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCX60_RS01960	COG4213	ABC transporter substrate-binding protein
HCX60_RS01965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HCX60_RS01980	COG0579	oxidoreductase
HCX60_RS02005	COG2267	carboxylic ester hydrolase activity
HCX60_RS02025	COG0346	lactoylglutathione lyase activity
HCX60_RS02030	COG0583	DNA-binding transcription factor activity
HCX60_RS02035	COG1879	ABC-type sugar transport system periplasmic component
HCX60_RS02040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS02045	COG1129	ABC transporter
HCX60_RS02065	COG1609	Transcriptional regulator
HCX60_RS02075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCX60_RS02080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCX60_RS02090	COG0583	DNA-binding transcription factor activity
HCX60_RS02105	COG0604	alcohol dehydrogenase
HCX60_RS02115	COG2205	protein histidine kinase activity
HCX60_RS02120	COG0745	RESPONSE REGULATOR receiver
HCX60_RS02130	COG1131	(ABC) transporter
HCX60_RS02140	COG0300	oxidoreductase activity
HCX60_RS02160	COG2353	YceI-like domain
HCX60_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS02205	COG1309	transcriptional regulator
HCX60_RS02210	COG1064	alcohol dehydrogenase
HCX60_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS02235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS02240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS02260	COG4214	carbohydrate transport
HCX60_RS02265	COG4213	ABC transporter substrate-binding protein
HCX60_RS02270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCX60_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS02365	COG0509	glycine decarboxylation via glycine cleavage system
HCX60_RS02390	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS02435	COG0395	ABC-type sugar transport system, permease component
HCX60_RS02440	COG1175	transmembrane transport
HCX60_RS02460	COG2340	Cysteine-rich secretory protein family
HCX60_RS02470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS02495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCX60_RS02495	COG0723	plastoquinol--plastocyanin reductase activity
HCX60_RS02505	COG2890	protein-(glutamine-N5) methyltransferase activity
HCX60_RS02530	COG3447	MASE1 domain protein
HCX60_RS02530	COG5001	Diguanylate cyclase
HCX60_RS02530	COG5002	protein histidine kinase activity
HCX60_RS02540	COG0693	protein deglycase activity
HCX60_RS02545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS02565	COG1335	isochorismatase
HCX60_RS02570	COG0028	Belongs to the TPP enzyme family
HCX60_RS02580	COG0516	GMP reductase activity
HCX60_RS02580	COG0517	IMP dehydrogenase activity
HCX60_RS02595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCX60_RS02675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HCX60_RS02680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS02740	COG2124	cytochrome p450
HCX60_RS02750	COG1309	transcriptional regulator
HCX60_RS02755	COG0009	L-threonylcarbamoyladenylate synthase
HCX60_RS02805	COG1793	dna ligase
HCX60_RS02805	COG3285	dna ligase
HCX60_RS02815	COG0181	hydroxymethylbilane synthase activity
HCX60_RS02850	COG0366	Alpha amylase catalytic
HCX60_RS02865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCX60_RS02870	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCX60_RS02955	COG5002	protein histidine kinase activity
HCX60_RS02970	COG3189	MarR family transcriptional regulator
HCX60_RS02990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS03060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS03060	COG0515	serine threonine protein kinase
HCX60_RS03070	COG3647	Membrane
HCX60_RS03080	COG0667	Aldo Keto reductase
HCX60_RS03110	COG0328	RNA-DNA hybrid ribonuclease activity
HCX60_RS03120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCX60_RS03130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCX60_RS03140	COG0740	serine-type endopeptidase activity
HCX60_RS03145	COG0740	serine-type endopeptidase activity
HCX60_RS03150	COG1396	sequence-specific DNA binding
HCX60_RS03155	COG1191	sigma factor activity
HCX60_RS03170	COG1716	ATPase activity
HCX60_RS03170	COG0842	Transport permease protein
HCX60_RS03170	COG1131	(ABC) transporter
HCX60_RS03185	COG0667	Aldo Keto reductase
HCX60_RS03190	COG0583	DNA-binding transcription factor activity
HCX60_RS03200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCX60_RS03205	COG0346	lactoylglutathione lyase activity
HCX60_RS03275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS03285	COG0431	NADPH-dependent FMN reductase
HCX60_RS03295	COG2409	Drug exporters of the RND superfamily
HCX60_RS03300	COG1846	Transcriptional regulator
HCX60_RS03305	COG0702	epimerase
HCX60_RS03370	COG2267	carboxylic ester hydrolase activity
HCX60_RS03380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCX60_RS03380	COG3320	Male sterility
HCX60_RS03390	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS03400	COG0673	inositol 2-dehydrogenase activity
HCX60_RS03460	COG1024	Enoyl-CoA hydratase
HCX60_RS03475	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS03485	COG2070	2-Nitropropane dioxygenase
HCX60_RS03535	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS03560	COG2326	polyphosphate kinase activity
HCX60_RS03565	COG4191	Histidine kinase
HCX60_RS03575	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HCX60_RS03580	COG0698	ribose 5-phosphate isomerase
HCX60_RS03595	COG2197	response regulator
HCX60_RS03605	COG1535	isochorismatase
HCX60_RS03605	COG3433	isochorismatase activity
HCX60_RS03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCX60_RS03620	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HCX60_RS03665	COG1874	Beta-galactosidase
HCX60_RS03665	COG0366	Alpha amylase catalytic
HCX60_RS03675	COG2376	Dihydroxyacetone kinase
HCX60_RS03680	COG1461	Dihydroxyacetone kinase
HCX60_RS03710	COG1902	pentaerythritol trinitrate reductase activity
HCX60_RS03710	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCX60_RS03730	COG2890	protein-(glutamine-N5) methyltransferase activity
HCX60_RS03745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HCX60_RS03750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCX60_RS03765	COG3458	cephalosporin-C deacetylase activity
HCX60_RS03795	COG0675	Transposase, IS605 OrfB family
HCX60_RS03805	COG2124	cytochrome p450
HCX60_RS03820	COG5650	phosphatidylinositol metabolic process
HCX60_RS03835	COG2066	Belongs to the glutaminase family
HCX60_RS03845	COG2186	Transcriptional regulator
HCX60_RS03850	COG1968	undecaprenyl-diphosphatase activity
HCX60_RS03855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCX60_RS03860	COG1993	acr, cog1993
HCX60_RS03865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCX60_RS03875	COG0640	Transcriptional regulator
HCX60_RS03895	COG1175	transmembrane transport
HCX60_RS03900	COG0395	ABC-type sugar transport system, permease component
HCX60_RS03915	COG1846	Transcriptional regulator
HCX60_RS03930	COG1414	Transcriptional regulator
HCX60_RS03945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCX60_RS03990	COG3340	Belongs to the peptidase S51 family
HCX60_RS04000	COG0309	Hydrogenase expression formation protein (HypE)
HCX60_RS04010	COG0298	carbon dioxide binding
HCX60_RS04015	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HCX60_RS04020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCX60_RS04025	COG0375	protein maturation
HCX60_RS04065	COG1024	Enoyl-CoA hydratase
HCX60_RS04065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCX60_RS04080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCX60_RS04090	COG0494	nUDIX hydrolase
HCX60_RS04110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCX60_RS04115	COG1215	transferase activity, transferring glycosyl groups
HCX60_RS04150	COG1349	DNA-binding transcription factor activity
HCX60_RS04185	COG1940	carbohydrate kinase activity
HCX60_RS04190	COG2813	Specifically methylates the guanine in position
HCX60_RS04200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCX60_RS04205	COG2814	Major facilitator Superfamily
HCX60_RS04210	COG0326	Molecular chaperone. Has ATPase activity
HCX60_RS04240	COG2197	response regulator
HCX60_RS04245	COG4585	Histidine kinase
HCX60_RS04265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS04270	COG1660	Displays ATPase and GTPase activities
HCX60_RS04310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCX60_RS04335	COG0204	Acyl-transferase
HCX60_RS04360	COG0584	glycerophosphoryl diester phosphodiesterase
HCX60_RS04400	COG0671	phosphoesterase, PA-phosphatase related
HCX60_RS04415	COG1309	transcriptional regulator
HCX60_RS04455	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS04475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCX60_RS04515	COG5006	permease, DMT superfamily
HCX60_RS04525	COG1278	Cold shock
HCX60_RS04545	COG2318	DinB family
HCX60_RS04555	COG0714	Associated with various cellular activities
HCX60_RS04565	COG3387	PFAM Glycoside hydrolase 15-related
HCX60_RS04580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS04585	COG1129	ABC transporter
HCX60_RS04590	COG2208	phosphoserine phosphatase activity
HCX60_RS04610	COG1116	anion transmembrane transporter activity
HCX60_RS04615	COG2072	flavoprotein involved in K transport
HCX60_RS04625	COG1132	(ABC) transporter
HCX60_RS04645	COG1132	(ABC) transporter
HCX60_RS04655	COG0254	rRNA binding
HCX60_RS04670	COG1946	Acyl-CoA thioesterase
HCX60_RS04680	COG2018	Roadblock/LC7 domain
HCX60_RS04740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCX60_RS04770	COG1940	carbohydrate kinase activity
HCX60_RS04770	COG1846	Transcriptional regulator
HCX60_RS04785	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS04820	COG0546	phosphoglycolate phosphatase activity
HCX60_RS04830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCX60_RS04835	COG2192	nodulation
HCX60_RS04845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCX60_RS04850	COG2226	methyltransferase
HCX60_RS04870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS04880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HCX60_RS05295	COG4106	trans-aconitate 2-methyltransferase activity
HCX60_RS05375	COG1309	transcriptional regulator
HCX60_RS05390	COG0730	response to heat
HCX60_RS05460	COG2226	methyltransferase
HCX60_RS05465	COG1937	Protein conserved in bacteria
HCX60_RS05490	COG2259	Doxx family
HCX60_RS05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS05535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCX60_RS05555	COG0640	Transcriptional regulator
HCX60_RS05575	COG0789	Transcriptional regulator
HCX60_RS05595	COG2072	flavoprotein involved in K transport
HCX60_RS05615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS05645	COG0789	Transcriptional regulator
HCX60_RS05745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCX60_RS05760	COG1535	isochorismatase
HCX60_RS05760	COG3433	isochorismatase activity
HCX60_RS05770	COG0148	phosphopyruvate hydratase activity
HCX60_RS05775	COG1120	ATPase activity
HCX60_RS05780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS05790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS05795	COG1535	isochorismatase
HCX60_RS05795	COG3433	isochorismatase activity
HCX60_RS05855	COG0601	transmembrane transport
HCX60_RS05860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS05865	COG0444	Belongs to the ABC transporter superfamily
HCX60_RS05870	COG4608	Belongs to the ABC transporter superfamily
HCX60_RS05875	COG0589	response to stress
HCX60_RS05885	COG0367	asparagine synthase
HCX60_RS05890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCX60_RS05890	COG2308	Evidence 4 Homologs of previously reported genes of
HCX60_RS05915	COG2814	Major facilitator Superfamily
HCX60_RS05930	COG0714	Associated with various cellular activities
HCX60_RS05950	COG2226	methyltransferase
HCX60_RS05965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCX60_RS05990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS06010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCX60_RS06025	COG2226	methyltransferase
HCX60_RS06040	COG3135	benzoate transporter
HCX60_RS06045	COG2197	response regulator
HCX60_RS06055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCX60_RS06065	COG0477	Major facilitator Superfamily
HCX60_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCX60_RS06085	COG0604	alcohol dehydrogenase
HCX60_RS06095	COG1733	regulation of RNA biosynthetic process
HCX60_RS06100	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HCX60_RS06105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCX60_RS06125	COG0300	oxidoreductase activity
HCX60_RS06125	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS06125	COG3321	synthase
HCX60_RS06125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS06130	COG0745	RESPONSE REGULATOR receiver
HCX60_RS06145	COG1090	epimerase
HCX60_RS06185	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS06215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCX60_RS06255	COG2867	negative regulation of translational initiation
HCX60_RS06260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCX60_RS06265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCX60_RS06305	COG4213	ABC transporter substrate-binding protein
HCX60_RS06315	COG4213	ABC transporter substrate-binding protein
HCX60_RS06325	COG4214	carbohydrate transport
HCX60_RS06350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCX60_RS06375	COG0673	inositol 2-dehydrogenase activity
HCX60_RS06385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS06390	COG1129	ABC transporter
HCX60_RS06395	COG1940	carbohydrate kinase activity
HCX60_RS06420	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS06425	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS06440	COG0492	ferredoxin-NADP+ reductase activity
HCX60_RS06445	COG1793	dna ligase
HCX60_RS06465	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS06475	COG0242	peptide deformylase activity
HCX60_RS06485	COG3442	glutamine amidotransferase
HCX60_RS06490	COG0205	6-phosphofructokinase activity
HCX60_RS06505	COG3275	phosphorelay sensor kinase activity
HCX60_RS06520	COG3279	Response regulator of the LytR AlgR family
HCX60_RS06525	COG1522	sequence-specific DNA binding
HCX60_RS06530	COG1834	amidinotransferase
HCX60_RS06535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCX60_RS06550	COG0204	Acyl-transferase
HCX60_RS06560	COG0829	nickel cation binding
HCX60_RS06565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCX60_RS06575	COG0804	urea catabolic process
HCX60_RS06580	COG0832	Belongs to the urease beta subunit family
HCX60_RS06585	COG0831	urea catabolic process
HCX60_RS06600	COG0791	NLP P60 protein
HCX60_RS06600	COG0741	lytic transglycosylase activity
HCX60_RS06625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCX60_RS06630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCX60_RS06635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCX60_RS06640	COG2226	methyltransferase
HCX60_RS06655	COG1136	(ABC) transporter
HCX60_RS06660	COG0577	efflux transmembrane transporter activity
HCX60_RS06660	COG1136	(ABC) transporter
HCX60_RS06695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCX60_RS06700	COG3663	DNA glycosylase
HCX60_RS06720	COG4585	Histidine kinase
HCX60_RS06725	COG2197	response regulator
HCX60_RS06730	COG1940	carbohydrate kinase activity
HCX60_RS06735	COG2188	Transcriptional regulator
HCX60_RS06740	COG0596	Alpha beta hydrolase
HCX60_RS06750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCX60_RS06760	COG0626	cystathionine gamma-synthase activity
HCX60_RS06780	COG1522	sequence-specific DNA binding
HCX60_RS06785	COG0419	ATPase involved in DNA repair
HCX60_RS06790	COG0420	3'-5' exonuclease activity
HCX60_RS06795	COG1739	Uncharacterized protein family UPF0029
HCX60_RS06810	COG1832	CoA-binding protein
HCX60_RS06820	COG0640	Transcriptional regulator
HCX60_RS06840	COG0110	maltose O-acetyltransferase activity
HCX60_RS06855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCX60_RS06875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCX60_RS06890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCX60_RS06910	COG0183	Belongs to the thiolase family
HCX60_RS06930	COG1968	undecaprenyl-diphosphatase activity
HCX60_RS06965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCX60_RS06975	COG2318	DinB family
HCX60_RS06990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCX60_RS06995	COG4166	transmembrane transport
HCX60_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS07170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCX60_RS07170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCX60_RS07185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCX60_RS07205	COG1716	ATPase activity
HCX60_RS07225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCX60_RS07255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCX60_RS07265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCX60_RS07285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCX60_RS07290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCX60_RS07295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCX60_RS07345	COG2814	Major facilitator Superfamily
HCX60_RS07350	COG4336	lyase activity
HCX60_RS07355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCX60_RS07360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCX60_RS07365	COG1984	allophanate hydrolase subunit 2
HCX60_RS07370	COG2755	lipolytic protein G-D-S-L family
HCX60_RS07375	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS07410	COG2364	Membrane
HCX60_RS07420	COG2270	Major facilitator Superfamily
HCX60_RS07435	COG1216	Glycosyl transferase, family 2
HCX60_RS07505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCX60_RS07510	COG0140	phosphoribosyl-ATP diphosphatase activity
HCX60_RS07515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCX60_RS07520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCX60_RS07520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCX60_RS07525	COG3201	nicotinamide mononucleotide transporter
HCX60_RS07545	COG1940	carbohydrate kinase activity
HCX60_RS07545	COG1846	Transcriptional regulator
HCX60_RS07550	COG2223	nitrite transmembrane transporter activity
HCX60_RS07560	COG2233	PERMEase
HCX60_RS07580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCX60_RS07610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HCX60_RS07620	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCX60_RS07630	COG2188	Transcriptional regulator
HCX60_RS07640	COG0531	amino acid
HCX60_RS07650	COG2390	Transcriptional regulator
HCX60_RS07655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCX60_RS07660	COG2409	Drug exporters of the RND superfamily
HCX60_RS07670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCX60_RS07685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCX60_RS07695	COG1758	RNA polymerase activity
HCX60_RS07700	COG0194	GDP metabolic process
HCX60_RS07710	COG0284	orotidine-5'-phosphate decarboxylase activity
HCX60_RS07715	COG0167	dihydroorotate dehydrogenase activity
HCX60_RS07720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCX60_RS07725	COG0505	Belongs to the CarA family
HCX60_RS07735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCX60_RS07740	COG0540	Belongs to the ATCase OTCase family
HCX60_RS07745	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCX60_RS07755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCX60_RS07760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCX60_RS07765	COG0006	proline dipeptidase activity
HCX60_RS07775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCX60_RS07780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCX60_RS07785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCX60_RS07790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCX60_RS07795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCX60_RS07800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCX60_RS07805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCX60_RS07820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCX60_RS07835	COG0124	histidyl-tRNA synthetase
HCX60_RS07845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCX60_RS07850	COG1196	nuclear chromosome segregation
HCX60_RS07865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCX60_RS07870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCX60_RS07875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCX60_RS07885	COG2255	four-way junction helicase activity
HCX60_RS07890	COG0632	four-way junction helicase activity
HCX60_RS07895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCX60_RS07900	COG0217	transcriptional regulatory protein
HCX60_RS07905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HCX60_RS07910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HCX60_RS07920	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS07925	COG1560	Kdo2-lipid A biosynthetic process
HCX60_RS07930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCX60_RS07950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCX60_RS07955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCX60_RS07970	COG2176	DNA-directed DNA polymerase activity
HCX60_RS07970	COG5002	protein histidine kinase activity
HCX60_RS08000	COG0395	ABC-type sugar transport system, permease component
HCX60_RS08005	COG1175	transmembrane transport
HCX60_RS08060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCX60_RS08060	COG0512	Glutamine amidotransferase of anthranilate synthase
HCX60_RS08115	COG1648	precorrin-2 dehydrogenase activity
HCX60_RS08115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCX60_RS08135	COG1464	Belongs to the NlpA lipoprotein family
HCX60_RS08140	COG2011	ABC-type metal ion transport system permease component
HCX60_RS08145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCX60_RS08175	COG0584	glycerophosphoryl diester phosphodiesterase
HCX60_RS08180	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS08180	COG0204	Acyl-transferase
HCX60_RS08190	COG4585	Histidine kinase
HCX60_RS08195	COG2197	response regulator
HCX60_RS08200	COG0477	Major facilitator Superfamily
HCX60_RS08215	COG0165	Argininosuccinate lyase
HCX60_RS08225	COG1017	nitric oxide dioxygenase activity
HCX60_RS08225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCX60_RS08240	COG1438	arginine binding
HCX60_RS08245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCX60_RS08250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCX60_RS08255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCX60_RS08260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCX60_RS08280	COG0697	spore germination
HCX60_RS08290	COG1649	PFAM Uncharacterised BCR, COG1649
HCX60_RS08315	COG0072	phenylalanine-tRNA ligase activity
HCX60_RS08315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCX60_RS08320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCX60_RS08325	COG5002	protein histidine kinase activity
HCX60_RS08330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCX60_RS08335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCX60_RS08340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCX60_RS08345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCX60_RS08395	COG0174	glutamine synthetase
HCX60_RS08405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCX60_RS08420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCX60_RS08430	COG4176	ABC-type proline glycine betaine transport system permease component
HCX60_RS08435	COG4175	Glycine betaine
HCX60_RS08435	COG0517	IMP dehydrogenase activity
HCX60_RS08440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCX60_RS08455	COG0564	pseudouridine synthase activity
HCX60_RS08515	COG0805	protein transport
HCX60_RS08520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCX60_RS08565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HCX60_RS08575	COG1609	Transcriptional regulator
HCX60_RS08580	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HCX60_RS08585	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HCX60_RS08600	COG4122	O-methyltransferase activity
HCX60_RS08605	COG1222	aaa ATPase
HCX60_RS08630	COG0517	IMP dehydrogenase activity
HCX60_RS08630	COG1994	Peptidase M50
HCX60_RS08640	COG2197	response regulator
HCX60_RS08650	COG0747	negative chemotaxis
HCX60_RS08660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCX60_RS08665	COG1410	methionine synthase
HCX60_RS08665	COG0646	methionine synthase
HCX60_RS08670	COG1414	Transcriptional regulator
HCX60_RS08675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCX60_RS08680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCX60_RS08685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCX60_RS08690	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCX60_RS08695	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HCX60_RS08700	COG0235	Class ii aldolase
HCX60_RS08705	COG0235	Class ii aldolase
HCX60_RS08705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCX60_RS08730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HCX60_RS08735	COG0402	S-adenosylhomocysteine deaminase activity
HCX60_RS08750	COG0215	cysteine-tRNA ligase activity
HCX60_RS08765	COG0406	alpha-ribazole phosphatase activity
HCX60_RS08770	COG0598	Magnesium transport protein CorA
HCX60_RS08780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS08785	COG0667	Aldo Keto reductase
HCX60_RS08815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS08845	COG3012	SEC-C Motif Domain Protein
HCX60_RS08850	COG2186	Transcriptional regulator
HCX60_RS08855	COG3265	gluconokinase activity
HCX60_RS08885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCX60_RS08890	COG2149	membrane
HCX60_RS08930	COG3876	Protein conserved in bacteria
HCX60_RS08950	COG0072	phenylalanine-tRNA ligase activity
HCX60_RS08950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCX60_RS08955	COG0789	Transcriptional regulator
HCX60_RS08975	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS09015	COG2851	Citrate transporter
HCX60_RS09020	COG0243	molybdopterin cofactor binding
HCX60_RS09025	COG1309	transcriptional regulator
HCX60_RS09035	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HCX60_RS09040	COG2188	Transcriptional regulator
HCX60_RS09050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCX60_RS09065	COG1595	DNA-templated transcription, initiation
HCX60_RS09085	COG2815	serine threonine protein kinase
HCX60_RS09085	COG0515	serine threonine protein kinase
HCX60_RS09090	COG2755	lipolytic protein G-D-S-L family
HCX60_RS09125	COG1725	Transcriptional regulator
HCX60_RS09150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCX60_RS09155	COG0587	DNA-directed DNA polymerase activity
HCX60_RS09185	COG1126	abc transporter atp-binding protein
HCX60_RS09195	COG0765	amino acid transport
HCX60_RS09215	COG1799	cell septum assembly
HCX60_RS09220	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS09225	COG0477	Major facilitator Superfamily
HCX60_RS09235	COG0671	phosphoesterase, PA-phosphatase related
HCX60_RS09245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCX60_RS09250	COG1652	LysM domain
HCX60_RS09265	COG1160	GTP binding
HCX60_RS09275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCX60_RS09305	COG1187	pseudouridine synthase activity
HCX60_RS09310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HCX60_RS09315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HCX60_RS09330	COG0686	Belongs to the AlaDH PNT family
HCX60_RS09340	COG0494	nUDIX hydrolase
HCX60_RS09345	COG0504	CTP synthase activity
HCX60_RS09350	COG3387	PFAM Glycoside hydrolase 15-related
HCX60_RS09360	COG0277	FAD linked oxidase domain protein
HCX60_RS09375	COG0497	DNA recombination
HCX60_RS09380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCX60_RS09400	COG1120	ATPase activity
HCX60_RS09405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS09410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS09415	COG0647	UMP catabolic process
HCX60_RS09450	COG2094	Belongs to the DNA glycosylase MPG family
HCX60_RS09460	COG1881	PFAM PEBP family protein
HCX60_RS09480	COG1119	ATPase activity
HCX60_RS09500	COG2197	response regulator
HCX60_RS09510	COG4221	oxidoreductase activity
HCX60_RS09525	COG0842	Transport permease protein
HCX60_RS09525	COG1131	(ABC) transporter
HCX60_RS09525	COG1716	ATPase activity
HCX60_RS09535	COG0560	Phosphoserine phosphatase
HCX60_RS09535	COG3830	Belongs to the UPF0237 family
HCX60_RS09540	COG0588	phosphoglycerate mutase activity
HCX60_RS09555	COG2186	Transcriptional regulator
HCX60_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS09575	COG0312	modulator of DNA gyrase
HCX60_RS09585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCX60_RS09605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCX60_RS09610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCX60_RS09625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCX60_RS09630	COG1063	alcohol dehydrogenase
HCX60_RS09640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCX60_RS09655	COG3387	PFAM Glycoside hydrolase 15-related
HCX60_RS09705	COG0488	(ABC) transporter
HCX60_RS09725	COG0235	Class ii aldolase
HCX60_RS09745	COG1492	cobalamin metabolic process
HCX60_RS09760	COG1797	cobyrinic acid a,c-diamide synthase activity
HCX60_RS09795	COG0765	amino acid transport
HCX60_RS09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCX60_RS09805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCX60_RS09810	COG0456	acetyltransferase
HCX60_RS09815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCX60_RS09820	COG1917	Cupin 2, conserved barrel domain protein
HCX60_RS09825	COG5285	phytanoyl-CoA dioxygenase
HCX60_RS09830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCX60_RS09855	COG1414	Transcriptional regulator
HCX60_RS09865	COG0768	penicillin binding
HCX60_RS09875	COG2252	PERMEase
HCX60_RS09880	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HCX60_RS09885	COG4677	pectinesterase activity
HCX60_RS09890	COG3866	Pectate lyase
HCX60_RS09915	COG0395	ABC-type sugar transport system, permease component
HCX60_RS09920	COG1175	transmembrane transport
HCX60_RS09930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS09935	COG1802	Transcriptional regulator
HCX60_RS09940	COG1234	tRNA 3'-trailer cleavage
HCX60_RS09955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS09960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS09965	COG1349	DNA-binding transcription factor activity
HCX60_RS09985	COG1802	Transcriptional regulator
HCX60_RS10015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS10025	COG1595	DNA-templated transcription, initiation
HCX60_RS10030	COG2171	N-acyltransferase activity
HCX60_RS10035	COG3226	Transcriptional regulator
HCX60_RS10040	COG2076	Multidrug Resistance protein
HCX60_RS10050	COG2151	metal-sulfur cluster biosynthetic enzyme
HCX60_RS10055	COG0822	iron-sulfur transferase activity
HCX60_RS10060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCX60_RS10065	COG0396	ATPase activity
HCX60_RS10075	COG0719	Fe-S assembly protein
HCX60_RS10100	COG1612	heme a metabolic process
HCX60_RS10120	COG0109	protoheme IX farnesyltransferase activity
HCX60_RS10130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCX60_RS10145	COG0363	glucosamine-6-phosphate deaminase activity
HCX60_RS10150	COG0395	ABC-type sugar transport system, permease component
HCX60_RS10155	COG1175	transmembrane transport
HCX60_RS10165	COG0366	Alpha amylase catalytic
HCX60_RS10170	COG1653	transport
HCX60_RS10180	COG1136	(ABC) transporter
HCX60_RS10200	COG0166	Belongs to the GPI family
HCX60_RS10210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCX60_RS10215	COG0149	triose-phosphate isomerase activity
HCX60_RS10220	COG0126	phosphoglycerate kinase activity
HCX60_RS10225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCX60_RS10235	COG1481	regulation of sporulation
HCX60_RS10240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCX60_RS10245	COG1660	Displays ATPase and GTPase activities
HCX60_RS10250	COG0322	excinuclease ABC activity
HCX60_RS10265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCX60_RS10275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS10280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCX60_RS10285	COG0765	amino acid transport
HCX60_RS10295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCX60_RS10300	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCX60_RS10305	COG0477	Major facilitator Superfamily
HCX60_RS10310	COG0387	Pfam Sodium calcium exchanger
HCX60_RS10330	COG0556	nucleotide-excision repair
HCX60_RS10340	COG0584	glycerophosphoryl diester phosphodiesterase
HCX60_RS10345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCX60_RS10350	COG0477	Major facilitator Superfamily
HCX60_RS10355	COG2313	pseudouridylate synthase activity
HCX60_RS10370	COG0598	Magnesium transport protein CorA
HCX60_RS10400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS10405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCX60_RS10450	COG1132	(ABC) transporter
HCX60_RS10490	COG0237	dephospho-CoA kinase activity
HCX60_RS10500	COG0539	negative regulation of cytoplasmic translation
HCX60_RS10545	COG2050	protein possibly involved in aromatic compounds catabolism
HCX60_RS10610	COG0737	Belongs to the 5'-nucleotidase family
HCX60_RS10630	COG1605	Chorismate mutase
HCX60_RS10630	COG0287	Prephenate dehydrogenase
HCX60_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS10650	COG1024	Enoyl-CoA hydratase
HCX60_RS10670	COG0183	Belongs to the thiolase family
HCX60_RS10675	COG1309	transcriptional regulator
HCX60_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS10685	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS10705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCX60_RS10710	COG2304	oxidoreductase activity
HCX60_RS10715	COG0705	Rhomboid family
HCX60_RS10735	COG0067	glutamate synthase
HCX60_RS10735	COG0070	glutamate synthase
HCX60_RS10735	COG0069	glutamate synthase activity
HCX60_RS10765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCX60_RS10775	COG2301	Belongs to the HpcH HpaI aldolase family
HCX60_RS10780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCX60_RS10790	COG0159	tryptophan synthase activity
HCX60_RS10795	COG0133	tryptophan synthase activity
HCX60_RS10805	COG0134	indole-3-glycerol-phosphate synthase activity
HCX60_RS10830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCX60_RS10840	COG0107	imidazoleglycerol-phosphate synthase activity
HCX60_RS10845	COG0251	oxidation-reduction process
HCX60_RS10850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCX60_RS10855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCX60_RS10865	COG0131	Imidazoleglycerol-phosphate dehydratase
HCX60_RS10870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCX60_RS10875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCX60_RS10915	COG1432	Conserved Protein
HCX60_RS10925	COG0587	DNA-directed DNA polymerase activity
HCX60_RS10965	COG2153	protein acetylation
HCX60_RS10975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCX60_RS10990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCX60_RS10995	COG3599	regulation of cell shape
HCX60_RS11005	COG1799	cell septum assembly
HCX60_RS11010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCX60_RS11020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCX60_RS11025	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCX60_RS11030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCX60_RS11040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCX60_RS11045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCX60_RS11055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCX60_RS11060	COG0768	penicillin binding
HCX60_RS11070	COG0275	rRNA processing
HCX60_RS11080	COG0714	Associated with various cellular activities
HCX60_RS11100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCX60_RS11120	COG1309	transcriptional regulator
HCX60_RS11145	COG0352	thiamine-phosphate diphosphorylase activity
HCX60_RS11165	COG2022	thiamine diphosphate biosynthetic process
HCX60_RS11165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCX60_RS11175	COG2022	thiamine diphosphate biosynthetic process
HCX60_RS11180	COG0515	serine threonine protein kinase
HCX60_RS11180	COG2815	serine threonine protein kinase
HCX60_RS11185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HCX60_RS11195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCX60_RS11200	COG2193	ferroxidase activity
HCX60_RS11205	COG0243	molybdopterin cofactor binding
HCX60_RS11210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HCX60_RS11225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCX60_RS11230	COG2197	response regulator
HCX60_RS11260	COG1940	carbohydrate kinase activity
HCX60_RS11270	COG0003	Pfam Anion-transporting ATPase
HCX60_RS11285	COG1022	Amp-dependent synthetase and ligase
HCX60_RS11290	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS11295	COG0534	Mate efflux family protein
HCX60_RS11315	COG3103	Sh3 type 3 domain protein
HCX60_RS11315	COG1388	LysM domain
HCX60_RS11315	COG0791	NLP P60 protein
HCX60_RS11345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCX60_RS11350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCX60_RS11355	COG0723	plastoquinol--plastocyanin reductase activity
HCX60_RS11360	COG2010	Cytochrome c
HCX60_RS11365	COG1845	cytochrome c oxidase, subunit III
HCX60_RS11375	COG1376	ErfK ybiS ycfS ynhG family protein
HCX60_RS11385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCX60_RS11390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCX60_RS11400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCX60_RS11420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCX60_RS11425	COG0515	serine threonine protein kinase
HCX60_RS11425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS11430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCX60_RS11435	COG2197	response regulator
HCX60_RS11440	COG4585	Histidine kinase
HCX60_RS11480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HCX60_RS11485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCX60_RS11485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCX60_RS11500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HCX60_RS11505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCX60_RS11510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCX60_RS11535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCX60_RS11560	COG0745	RESPONSE REGULATOR receiver
HCX60_RS11570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCX60_RS11615	COG0321	lipoyl(octanoyl) transferase activity
HCX60_RS11620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCX60_RS11640	COG0174	glutamine synthetase
HCX60_RS11650	COG0501	Belongs to the peptidase M48B family
HCX60_RS11695	COG0745	RESPONSE REGULATOR receiver
HCX60_RS11710	COG2197	response regulator
HCX60_RS11745	COG1309	transcriptional regulator
HCX60_RS11770	COG0366	Alpha amylase catalytic
HCX60_RS11775	COG3833	ABC-type maltose transport systems, permease component
HCX60_RS11780	COG1175	transmembrane transport
HCX60_RS11790	COG1609	Transcriptional regulator
HCX60_RS11800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HCX60_RS11810	COG0174	glutamine synthetase
HCX60_RS11820	COG1959	2 iron, 2 sulfur cluster binding
HCX60_RS11855	COG2814	Major facilitator Superfamily
HCX60_RS11870	COG0477	Major facilitator Superfamily
HCX60_RS11875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCX60_RS11895	COG1994	Peptidase M50
HCX60_RS11935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS11940	COG1120	ATPase activity
HCX60_RS11950	COG2837	iron assimilation
HCX60_RS11955	COG0672	)-iron permease
HCX60_RS11980	COG2814	Major facilitator Superfamily
HCX60_RS11985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCX60_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS12005	COG1136	(ABC) transporter
HCX60_RS12015	COG2259	Doxx family
HCX60_RS12030	COG1201	RNA secondary structure unwinding
HCX60_RS12175	COG1674	ftsk spoiiie
HCX60_RS12200	COG0789	Transcriptional regulator
HCX60_RS12210	COG0557	exoribonuclease II activity
HCX60_RS12215	COG3022	response to hydroperoxide
HCX60_RS12220	COG0800	Aldolase
HCX60_RS12235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCX60_RS12255	COG2030	dehydratase
HCX60_RS12270	COG2197	response regulator
HCX60_RS12300	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCX60_RS12310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS12330	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS12335	COG1309	transcriptional regulator
HCX60_RS12405	COG3619	membrane
HCX60_RS12415	COG2124	cytochrome p450
HCX60_RS12420	COG0183	Belongs to the thiolase family
HCX60_RS12455	COG3209	COG3209 Rhs family protein
HCX60_RS12470	COG4122	O-methyltransferase activity
HCX60_RS12510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCX60_RS12540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCX60_RS12580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCX60_RS12595	COG1358	cellular component organization or biogenesis
HCX60_RS12640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HCX60_RS12650	COG0477	Major facilitator Superfamily
HCX60_RS12655	COG1309	transcriptional regulator
HCX60_RS12670	COG0667	Aldo Keto reductase
HCX60_RS12675	COG0789	Transcriptional regulator
HCX60_RS12705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCX60_RS12710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCX60_RS12715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCX60_RS12745	COG1280	lysine exporter protein (LysE YggA)
HCX60_RS12760	COG2130	NADP-dependent
HCX60_RS12800	COG1129	ABC transporter
HCX60_RS12805	COG4214	carbohydrate transport
HCX60_RS12815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCX60_RS12890	COG3386	PFAM SMP-30 Gluconolaconase
HCX60_RS12895	COG1414	Transcriptional regulator
HCX60_RS12915	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS12920	COG0825	malonyl-CoA metabolic process
HCX60_RS12920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCX60_RS12935	COG2255	four-way junction helicase activity
HCX60_RS12945	COG1077	Cell shape determining protein MreB Mrl
HCX60_RS12960	COG4565	transcriptional regulatory protein
HCX60_RS12965	COG3290	protein histidine kinase activity
HCX60_RS12985	COG0589	response to stress
HCX60_RS13065	COG1070	Carbohydrate kinase
HCX60_RS13080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCX60_RS13085	COG0358	DNA primase activity
HCX60_RS13095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HCX60_RS13105	COG2949	membrane
HCX60_RS13110	COG0243	molybdopterin cofactor binding
HCX60_RS13140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCX60_RS13145	COG2146	nitrite reductase [NAD(P)H] activity
HCX60_RS13145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCX60_RS13155	COG2205	protein histidine kinase activity
HCX60_RS13200	COG1136	(ABC) transporter
HCX60_RS13210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCX60_RS13210	COG0574	Belongs to the PEP-utilizing enzyme family
HCX60_RS13215	COG1846	Transcriptional regulator
HCX60_RS13215	COG1940	carbohydrate kinase activity
HCX60_RS13310	COG0667	Aldo Keto reductase
HCX60_RS13315	COG0423	glycine-tRNA ligase activity
HCX60_RS13320	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCX60_RS13320	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCX60_RS13325	COG1121	(ABC) transporter
HCX60_RS13330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCX60_RS13360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCX60_RS13365	COG1381	Involved in DNA repair and RecF pathway recombination
HCX60_RS13405	COG0456	acetyltransferase
HCX60_RS13405	COG1214	PFAM Peptidase M22, glycoprotease
HCX60_RS13415	COG1595	DNA-templated transcription, initiation
HCX60_RS13430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCX60_RS13450	COG2723	6-phospho-beta-galactosidase activity
HCX60_RS13470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCX60_RS13495	COG2315	Protein conserved in bacteria
HCX60_RS13505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCX60_RS13515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCX60_RS13520	COG4948	Mandelate Racemase Muconate Lactonizing
HCX60_RS13525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS13555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCX60_RS13560	COG1234	tRNA 3'-trailer cleavage
HCX60_RS13565	COG0537	adenosine 5'-monophosphoramidase activity
HCX60_RS13570	COG0793	Belongs to the peptidase S41A family
HCX60_RS13570	COG4946	Tricorn protease homolog
HCX60_RS13595	COG0484	heat shock protein binding
HCX60_RS13600	COG1420	regulation of RNA biosynthetic process
HCX60_RS13635	COG0481	GTPase activity
HCX60_RS13640	COG0268	Binds directly to 16S ribosomal RNA
HCX60_RS13670	COG1596	polysaccharide export
HCX60_RS13670	COG1555	photosystem II stabilization
HCX60_RS13675	COG1307	EDD domain protein, DegV family
HCX60_RS13685	COG0495	leucyl-tRNA aminoacylation
HCX60_RS13695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HCX60_RS13720	COG0588	phosphoglycerate mutase activity
HCX60_RS13725	COG0799	negative regulation of ribosome biogenesis
HCX60_RS13735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCX60_RS13750	COG0501	Belongs to the peptidase M48B family
HCX60_RS13765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCX60_RS13775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCX60_RS13785	COG1216	Glycosyl transferase, family 2
HCX60_RS13800	COG3540	Alkaline phosphatase
HCX60_RS13805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCX60_RS13810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCX60_RS13815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCX60_RS13870	COG0673	inositol 2-dehydrogenase activity
HCX60_RS13875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCX60_RS13905	COG0772	Belongs to the SEDS family
HCX60_RS13925	COG1077	Cell shape determining protein MreB Mrl
HCX60_RS13930	COG0105	UTP biosynthetic process
HCX60_RS13940	COG0285	dihydrofolate synthase activity
HCX60_RS13950	COG0525	valine-tRNA ligase activity
HCX60_RS13960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCX60_RS13965	COG0740	serine-type endopeptidase activity
HCX60_RS13970	COG0740	serine-type endopeptidase activity
HCX60_RS13975	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCX60_RS13995	COG3594	Acyltransferase
HCX60_RS14010	COG4552	Acetyltransferase involved in intracellular survival and related
HCX60_RS14025	COG1113	amino acid transport
HCX60_RS14050	COG1940	carbohydrate kinase activity
HCX60_RS14060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCX60_RS14065	COG1116	anion transmembrane transporter activity
HCX60_RS14070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS14080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCX60_RS14140	COG0697	spore germination
HCX60_RS14145	COG1846	Transcriptional regulator
HCX60_RS14150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCX60_RS14165	COG2188	Transcriptional regulator
HCX60_RS14190	COG1595	DNA-templated transcription, initiation
HCX60_RS14200	COG1131	(ABC) transporter
HCX60_RS14220	COG0668	transmembrane transport
HCX60_RS14235	COG1940	carbohydrate kinase activity
HCX60_RS14240	COG1653	transport
HCX60_RS14245	COG1175	transmembrane transport
HCX60_RS14250	COG0395	ABC-type sugar transport system, permease component
HCX60_RS14255	COG1486	melibiose metabolic process
HCX60_RS14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCX60_RS14330	COG2132	Multicopper oxidase
HCX60_RS14340	COG0629	single-stranded DNA binding
HCX60_RS14365	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCX60_RS14390	COG2304	oxidoreductase activity
HCX60_RS14425	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS14430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCX60_RS14510	COG1131	(ABC) transporter
HCX60_RS14525	COG3962	Belongs to the TPP enzyme family
HCX60_RS14530	COG3718	enzyme involved in inositol metabolism
HCX60_RS14540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCX60_RS14560	COG2409	Drug exporters of the RND superfamily
HCX60_RS14585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCX60_RS14610	COG0673	inositol 2-dehydrogenase activity
HCX60_RS14630	COG2211	Major facilitator Superfamily
HCX60_RS14650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCX60_RS14660	COG0596	Alpha beta hydrolase
HCX60_RS14675	COG1472	Belongs to the glycosyl hydrolase 3 family
HCX60_RS14705	COG2356	endonuclease I
HCX60_RS14730	COG1946	Acyl-CoA thioesterase
HCX60_RS14740	COG1309	transcriptional regulator
HCX60_RS14745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCX60_RS14760	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS14775	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HCX60_RS14805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCX60_RS14815	COG0589	response to stress
HCX60_RS14825	COG4977	sequence-specific DNA binding
HCX60_RS14830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HCX60_RS14865	COG0395	ABC-type sugar transport system, permease component
HCX60_RS14905	COG3979	chitinase
HCX60_RS14915	COG0745	RESPONSE REGULATOR receiver
HCX60_RS14940	COG0406	alpha-ribazole phosphatase activity
HCX60_RS15010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS15020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCX60_RS15025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCX60_RS15030	COG0765	amino acid transport
HCX60_RS15035	COG0765	amino acid transport
HCX60_RS15040	COG1126	abc transporter atp-binding protein
HCX60_RS15060	COG3397	chitin binding
HCX60_RS15105	COG0673	inositol 2-dehydrogenase activity
HCX60_RS15110	COG4702	Belongs to the UPF0303 family
HCX60_RS15130	COG3739	integral membrane protein
HCX60_RS15135	COG3764	Sortase (surface protein transpeptidase)
HCX60_RS15225	COG2271	Major facilitator Superfamily
HCX60_RS15230	COG2733	membrane
HCX60_RS15245	COG4555	ABC transporter
HCX60_RS15260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCX60_RS15265	COG2076	Multidrug Resistance protein
HCX60_RS15290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCX60_RS15300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCX60_RS15305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCX60_RS15310	COG1263	PTS System
HCX60_RS15315	COG1263	PTS System
HCX60_RS15345	COG1113	amino acid transport
HCX60_RS15355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCX60_RS15365	COG1335	isochorismatase
HCX60_RS15400	COG0277	FAD linked oxidase domain protein
HCX60_RS15410	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCX60_RS15420	COG1174	glycine betaine transport
HCX60_RS15425	COG1125	glycine betaine transport
HCX60_RS15425	COG0517	IMP dehydrogenase activity
HCX60_RS15430	COG1174	glycine betaine transport
HCX60_RS15440	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCX60_RS15515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCX60_RS15525	COG0596	Alpha beta hydrolase
HCX60_RS15540	COG0667	Aldo Keto reductase
HCX60_RS15545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCX60_RS15560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCX60_RS15565	COG0395	ABC-type sugar transport system, permease component
HCX60_RS15570	COG1175	transmembrane transport
HCX60_RS15585	COG1678	Uncharacterized ACR, COG1678
HCX60_RS15590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCX60_RS15595	COG0776	regulation of translation
HCX60_RS15605	COG3973	AAA domain
HCX60_RS15630	COG2223	nitrite transmembrane transporter activity
HCX60_RS15660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCX60_RS15665	COG0793	Belongs to the peptidase S41A family
HCX60_RS15675	COG2884	Cell division ATP-binding protein ftsE
HCX60_RS15690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCX60_RS15695	COG0515	serine threonine protein kinase
HCX60_RS15720	COG0395	ABC-type sugar transport system, permease component
HCX60_RS15725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCX60_RS15730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCX60_RS15730	COG0463	Glycosyl transferase, family 2
HCX60_RS15735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCX60_RS15750	COG1764	response to oxidative stress
HCX60_RS15755	COG1846	Transcriptional regulator
HCX60_RS15785	COG1134	teichoic acid transport
HCX60_RS15790	COG2902	Dehydrogenase
HCX60_RS15815	COG0653	protein targeting
HCX60_RS15825	COG3214	Protein conserved in bacteria
HCX60_RS15830	COG2197	response regulator
HCX60_RS15835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCX60_RS15845	COG0823	Involved in the tonB-independent uptake of proteins
HCX60_RS15850	COG5002	protein histidine kinase activity
HCX60_RS15855	COG0745	RESPONSE REGULATOR receiver
HCX60_RS15860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCX60_RS15880	COG0714	Associated with various cellular activities
HCX60_RS15920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCX60_RS15930	COG1482	cell wall glycoprotein biosynthetic process
HCX60_RS15940	COG2835	tetraacyldisaccharide 4'-kinase activity
HCX60_RS15945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCX60_RS15980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCX60_RS15985	COG0778	Nitroreductase
HCX60_RS15985	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HCX60_RS15995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCX60_RS16010	COG1316	TRANSCRIPTIONal
HCX60_RS16015	COG1316	TRANSCRIPTIONal
HCX60_RS16025	COG0463	Glycosyl transferase, family 2
HCX60_RS16045	COG1316	TRANSCRIPTIONal
HCX60_RS16055	COG1902	pentaerythritol trinitrate reductase activity
HCX60_RS16110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCX60_RS16140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCX60_RS16155	COG2205	protein histidine kinase activity
HCX60_RS16160	COG0745	RESPONSE REGULATOR receiver
HCX60_RS16165	COG3104	oligopeptide transport
HCX60_RS16195	COG1366	Belongs to the anti-sigma-factor antagonist family
HCX60_RS16200	COG1191	sigma factor activity
HCX60_RS16205	COG1228	amidohydrolase
HCX60_RS16210	COG0402	S-adenosylhomocysteine deaminase activity
HCX60_RS16215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS16220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCX60_RS16270	COG0183	Belongs to the thiolase family
HCX60_RS16305	COG1136	(ABC) transporter
HCX60_RS16305	COG0577	efflux transmembrane transporter activity
HCX60_RS16310	COG0577	efflux transmembrane transporter activity
HCX60_RS16315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCX60_RS16320	COG1252	NADH dehydrogenase
HCX60_RS16350	COG0148	phosphopyruvate hydratase activity
HCX60_RS16415	COG1136	(ABC) transporter
HCX60_RS16415	COG0577	efflux transmembrane transporter activity
HCX60_RS16420	COG1136	(ABC) transporter
HCX60_RS16435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCX60_RS16465	COG4585	Histidine kinase
HCX60_RS16475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCX60_RS16480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCX60_RS16485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCX60_RS16490	COG0193	aminoacyl-tRNA hydrolase activity
HCX60_RS16500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCX60_RS16510	COG1309	transcriptional regulator
HCX60_RS16525	COG4106	trans-aconitate 2-methyltransferase activity
HCX60_RS16530	COG1846	Transcriptional regulator
HCX60_RS16535	COG2197	response regulator
HCX60_RS16555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCX60_RS16620	COG0488	(ABC) transporter
HCX60_RS16625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCX60_RS16630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCX60_RS16635	COG3584	3D domain protein
HCX60_RS16635	COG3583	domain protein
HCX60_RS16640	COG0084	hydrolase, TatD family'
HCX60_RS16665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCX60_RS16670	COG2188	Transcriptional regulator
HCX60_RS16735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HCX60_RS16750	COG0768	penicillin binding
HCX60_RS16760	COG0310	cobalt ion transport
HCX60_RS16770	COG1122	ATPase activity
HCX60_RS16775	COG1846	Transcriptional regulator
HCX60_RS16780	COG1764	response to oxidative stress
HCX60_RS16805	COG0442	prolyl-tRNA aminoacylation
HCX60_RS16820	COG2409	Drug exporters of the RND superfamily
HCX60_RS16830	COG4946	Tricorn protease homolog
HCX60_RS16830	COG0793	Belongs to the peptidase S41A family
HCX60_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS16845	COG2267	carboxylic ester hydrolase activity
HCX60_RS16850	COG2072	flavoprotein involved in K transport
HCX60_RS16860	COG0708	Exodeoxyribonuclease III
HCX60_RS16885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCX60_RS16890	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCX60_RS16890	COG0315	cyclic pyranopterin monophosphate synthase activity
HCX60_RS16895	COG0315	cyclic pyranopterin monophosphate synthase activity
HCX60_RS16905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCX60_RS16910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCX60_RS16940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCX60_RS16950	COG1970	mechanosensitive ion channel activity
HCX60_RS16965	COG3191	aminopeptidase activity
HCX60_RS16970	COG1376	ErfK ybiS ycfS ynhG family protein
HCX60_RS16985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCX60_RS16985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCX60_RS16985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCX60_RS16995	COG1349	DNA-binding transcription factor activity
HCX60_RS17000	COG0477	Major facilitator Superfamily
HCX60_RS17020	COG1247	-acetyltransferase
HCX60_RS17025	COG3384	dioxygenase
HCX60_RS17030	COG1846	Transcriptional regulator
HCX60_RS17060	COG1609	Transcriptional regulator
HCX60_RS17145	COG0475	glutathione-regulated potassium exporter activity
HCX60_RS17170	COG2197	response regulator
HCX60_RS17180	COG2268	Band 7 protein
HCX60_RS17185	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCX60_RS17205	COG0386	Belongs to the glutathione peroxidase family
HCX60_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS17275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCX60_RS17285	COG0477	Major facilitator Superfamily
HCX60_RS17295	COG0367	asparagine synthase
HCX60_RS17315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCX60_RS17330	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS17335	COG2867	negative regulation of translational initiation
HCX60_RS17335	COG2226	methyltransferase
HCX60_RS17365	COG2226	methyltransferase
HCX60_RS17365	COG2867	negative regulation of translational initiation
HCX60_RS17375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCX60_RS17380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCX60_RS17385	COG0662	Cupin 2, conserved barrel domain protein
HCX60_RS17395	COG3104	oligopeptide transport
HCX60_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS17415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCX60_RS17465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HCX60_RS17490	COG3903	Transcriptional regulator
HCX60_RS17490	COG3629	intracellular signal transduction
HCX60_RS17505	COG0137	argininosuccinate synthase activity
HCX60_RS17510	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS17520	COG1024	Enoyl-CoA hydratase
HCX60_RS17545	COG2442	InterPro IPR007367
HCX60_RS17550	COG0515	serine threonine protein kinase
HCX60_RS17550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS17560	COG1309	transcriptional regulator
HCX60_RS17565	COG1522	sequence-specific DNA binding
HCX60_RS17570	COG1280	lysine exporter protein (LysE YggA)
HCX60_RS17580	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS17595	COG0259	pyridoxamine-phosphate oxidase activity
HCX60_RS17635	COG2072	flavoprotein involved in K transport
HCX60_RS17685	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS17690	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS17705	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS17710	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS17730	COG1366	Belongs to the anti-sigma-factor antagonist family
HCX60_RS17785	COG2945	thiolester hydrolase activity
HCX60_RS17785	COG0596	Alpha beta hydrolase
HCX60_RS17795	COG4821	SIS domain
HCX60_RS17820	COG0259	pyridoxamine-phosphate oxidase activity
HCX60_RS17840	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS17855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCX60_RS17885	COG0277	FAD linked oxidase domain protein
HCX60_RS17885	COG0247	lactate metabolic process
HCX60_RS17890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCX60_RS17935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HCX60_RS17955	COG0667	Aldo Keto reductase
HCX60_RS17980	COG2252	PERMEase
HCX60_RS17990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCX60_RS18020	COG2814	Major facilitator Superfamily
HCX60_RS18030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCX60_RS18035	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HCX60_RS18040	COG1278	Cold shock
HCX60_RS18070	COG1061	Type III restriction enzyme res subunit
HCX60_RS18085	COG3973	AAA domain
HCX60_RS18110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCX60_RS18150	COG0584	glycerophosphoryl diester phosphodiesterase
HCX60_RS18160	COG0459	protein refolding
HCX60_RS18180	COG0463	Glycosyl transferase, family 2
HCX60_RS18185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HCX60_RS18225	COG5001	Diguanylate cyclase
HCX60_RS18225	COG3300	MHYT domain
HCX60_RS18300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCX60_RS18320	COG0723	plastoquinol--plastocyanin reductase activity
HCX60_RS18320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCX60_RS18355	COG3903	Transcriptional regulator
HCX60_RS18355	COG3629	intracellular signal transduction
HCX60_RS18370	COG3842	ATPase activity
HCX60_RS18380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCX60_RS18390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCX60_RS18395	COG0215	cysteine-tRNA ligase activity
HCX60_RS18400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCX60_RS18405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCX60_RS18410	COG1329	Transcriptional regulator
HCX60_RS18430	COG5002	protein histidine kinase activity
HCX60_RS18455	COG0588	phosphoglycerate mutase activity
HCX60_RS18535	COG1742	UPF0060 membrane protein
HCX60_RS18540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCX60_RS18550	COG0604	alcohol dehydrogenase
HCX60_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS18550	COG3321	synthase
HCX60_RS18575	COG2186	Transcriptional regulator
HCX60_RS18590	COG4552	Acetyltransferase involved in intracellular survival and related
HCX60_RS18600	COG1490	D-aminoacyl-tRNA deacylase activity
HCX60_RS18605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCX60_RS18615	COG3485	protocatechuate 3,4-dioxygenase
HCX60_RS18655	COG2897	thiosulfate sulfurtransferase activity
HCX60_RS18680	COG0745	RESPONSE REGULATOR receiver
HCX60_RS18685	COG1609	Transcriptional regulator
HCX60_RS18690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCX60_RS18700	COG0745	RESPONSE REGULATOR receiver
HCX60_RS18710	COG0737	Belongs to the 5'-nucleotidase family
HCX60_RS18715	COG0456	acetyltransferase
HCX60_RS18730	COG1131	(ABC) transporter
HCX60_RS18745	COG1725	Transcriptional regulator
HCX60_RS18750	COG3842	ATPase activity
HCX60_RS18765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCX60_RS18795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCX60_RS18800	COG0306	phosphate transporter
HCX60_RS18810	COG1937	Protein conserved in bacteria
HCX60_RS18830	COG0277	FAD linked oxidase domain protein
HCX60_RS18835	COG0671	phosphoesterase, PA-phosphatase related
HCX60_RS18840	COG0741	lytic transglycosylase activity
HCX60_RS18840	COG1196	nuclear chromosome segregation
HCX60_RS18840	COG0739	heme binding
HCX60_RS18915	COG2226	methyltransferase
HCX60_RS18925	COG1252	NADH dehydrogenase
HCX60_RS18955	COG0579	oxidoreductase
HCX60_RS18960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCX60_RS18970	COG0667	Aldo Keto reductase
HCX60_RS18985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCX60_RS18985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCX60_RS18995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCX60_RS19060	COG0513	Belongs to the DEAD box helicase family
HCX60_RS19095	COG1643	Atp-dependent helicase
HCX60_RS19120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCX60_RS19130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCX60_RS19145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCX60_RS19150	COG0047	phosphoribosylformylglycinamidine synthase activity
HCX60_RS19155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCX60_RS19185	COG4585	Histidine kinase
HCX60_RS19200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCX60_RS19215	COG0151	Belongs to the GarS family
HCX60_RS19250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCX60_RS19285	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS19325	COG0433	COG0433 Predicted ATPase
HCX60_RS19340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCX60_RS19370	COG4691	Plasmid stability protein
HCX60_RS19390	COG1191	sigma factor activity
HCX60_RS19395	COG1191	sigma factor activity
HCX60_RS19420	COG3467	pyridoxamine 5'-phosphate
HCX60_RS19425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCX60_RS19435	COG2205	protein histidine kinase activity
HCX60_RS19440	COG0745	RESPONSE REGULATOR receiver
HCX60_RS19455	COG1846	Transcriptional regulator
HCX60_RS19500	COG1309	transcriptional regulator
HCX60_RS19505	COG2814	Major facilitator Superfamily
HCX60_RS19510	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS19515	COG1595	DNA-templated transcription, initiation
HCX60_RS19600	COG0653	protein targeting
HCX60_RS19620	COG0006	proline dipeptidase activity
HCX60_RS19640	COG1999	signal sequence binding
HCX60_RS19655	COG2837	iron assimilation
HCX60_RS19660	COG0077	Prephenate dehydratase
HCX60_RS19665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCX60_RS19670	COG0561	phosphatase activity
HCX60_RS19720	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HCX60_RS19735	COG0561	phosphatase activity
HCX60_RS19745	COG4988	ABC transporter
HCX60_RS19750	COG1294	oxidase, subunit
HCX60_RS19755	COG1271	oxidase subunit
HCX60_RS19760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCX60_RS19765	COG1609	Transcriptional regulator
HCX60_RS19785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCX60_RS19810	COG0662	Cupin 2, conserved barrel domain protein
HCX60_RS19815	COG1950	PFAM Membrane protein of
HCX60_RS19820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS19825	COG0626	cystathionine gamma-synthase activity
HCX60_RS19855	COG2814	Major facilitator Superfamily
HCX60_RS19875	COG2945	thiolester hydrolase activity
HCX60_RS19875	COG0596	Alpha beta hydrolase
HCX60_RS19880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCX60_RS19885	COG0305	Participates in initiation and elongation during chromosome replication
HCX60_RS19895	COG0359	binds to the 23S rRNA
HCX60_RS19900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCX60_RS19905	COG0629	single-stranded DNA binding
HCX60_RS19910	COG0360	Binds together with S18 to 16S ribosomal RNA
HCX60_RS19935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCX60_RS19960	COG0617	tRNA 3'-terminal CCA addition
HCX60_RS19975	COG0515	serine threonine protein kinase
HCX60_RS19975	COG2815	serine threonine protein kinase
HCX60_RS19980	COG1595	DNA-templated transcription, initiation
HCX60_RS19990	COG0492	ferredoxin-NADP+ reductase activity
HCX60_RS19995	COG3118	belongs to the thioredoxin family
HCX60_RS20010	COG1192	Involved in chromosome partitioning
HCX60_RS20015	COG0357	Ribosomal RNA small subunit methyltransferase G
HCX60_RS20025	COG0706	membrane insertase activity
HCX60_RS20030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCX60_RS20035	COG0594	ribonuclease P activity
HCX60_RS20045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCX60_RS20050	COG0592	DNA-directed DNA polymerase activity
HCX60_RS20055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HCX60_RS20060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCX60_RS20065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HCX60_RS20070	COG0187	DNA topoisomerase II activity
HCX60_RS20075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCX60_RS20145	COG0515	serine threonine protein kinase
HCX60_RS20170	COG0705	Rhomboid family
HCX60_RS20185	COG3764	Sortase (surface protein transpeptidase)
HCX60_RS20200	COG3764	Sortase (surface protein transpeptidase)
HCX60_RS20205	COG3764	Sortase (surface protein transpeptidase)
HCX60_RS20210	COG0515	serine threonine protein kinase
HCX60_RS20215	COG0768	penicillin binding
HCX60_RS20230	COG1716	ATPase activity
HCX60_RS20265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCX60_RS20345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCX60_RS20375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCX60_RS20380	COG1309	transcriptional regulator
HCX60_RS20385	COG1522	sequence-specific DNA binding
HCX60_RS20405	COG0746	molybdenum cofactor guanylyltransferase activity
HCX60_RS20415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCX60_RS20450	COG0515	serine threonine protein kinase
HCX60_RS20455	COG0515	serine threonine protein kinase
HCX60_RS20465	COG0022	dehydrogenase e1 component
HCX60_RS20470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCX60_RS20525	COG1362	aminopeptidase activity
HCX60_RS20530	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS20545	COG1741	Belongs to the pirin family
HCX60_RS20565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCX60_RS20610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCX60_RS20635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCX60_RS20675	COG0701	Predicted permease
HCX60_RS20690	COG1957	nucleoside hydrolase
HCX60_RS20700	COG0366	Alpha amylase catalytic
HCX60_RS20725	COG0531	amino acid
HCX60_RS20810	COG4941	Belongs to the sigma-70 factor family
HCX60_RS20815	COG3795	YCII-related domain
HCX60_RS20825	COG1316	TRANSCRIPTIONal
HCX60_RS20855	COG0135	phosphoribosylanthranilate isomerase activity
HCX60_RS20910	COG0513	Belongs to the DEAD box helicase family
HCX60_RS20915	COG1278	Cold shock
HCX60_RS20970	COG3629	intracellular signal transduction
HCX60_RS20970	COG3903	Transcriptional regulator
HCX60_RS21000	COG2188	Transcriptional regulator
HCX60_RS21015	COG0717	Belongs to the dCTP deaminase family
HCX60_RS21020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HCX60_RS21065	COG0247	lactate metabolic process
HCX60_RS21065	COG2181	nitrate reductase activity
HCX60_RS21070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCX60_RS21075	COG0443	Heat shock 70 kDa protein
HCX60_RS21080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCX60_RS21085	COG0484	heat shock protein binding
HCX60_RS21090	COG0789	Transcriptional regulator
HCX60_RS21095	COG4213	ABC transporter substrate-binding protein
HCX60_RS21100	COG1305	Transglutaminase-like
HCX60_RS21110	COG2308	Evidence 4 Homologs of previously reported genes of
HCX60_RS21145	COG0542	response to heat
HCX60_RS21170	COG1131	(ABC) transporter
HCX60_RS21175	COG1131	(ABC) transporter
HCX60_RS21215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCX60_RS21220	COG0191	fructose-bisphosphate aldolase activity
HCX60_RS21225	COG0477	Major facilitator Superfamily
HCX60_RS21240	COG3844	kynureninase activity
HCX60_RS21260	COG4585	Histidine kinase
HCX60_RS21265	COG2197	response regulator
HCX60_RS21270	COG4585	Histidine kinase
HCX60_RS21275	COG2197	response regulator
HCX60_RS21285	COG3559	Exporter of polyketide antibiotics
HCX60_RS21290	COG1131	(ABC) transporter
HCX60_RS21305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCX60_RS21335	COG1802	Transcriptional regulator
HCX60_RS21345	COG0693	protein deglycase activity
HCX60_RS21365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCX60_RS21370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCX60_RS21395	COG1595	DNA-templated transcription, initiation
HCX60_RS21420	COG0701	Predicted permease
HCX60_RS21515	COG1408	metallophosphoesterase
HCX60_RS21535	COG0003	Pfam Anion-transporting ATPase
HCX60_RS21560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS21595	COG2267	carboxylic ester hydrolase activity
HCX60_RS21610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCX60_RS21615	COG0288	reversible hydration of carbon dioxide
HCX60_RS21675	COG1111	helicase
HCX60_RS21675	COG1205	dead DEAH box helicase
HCX60_RS21680	COG1366	Belongs to the anti-sigma-factor antagonist family
HCX60_RS21685	COG2172	sigma factor antagonist activity
HCX60_RS21690	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HCX60_RS21710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCX60_RS21710	COG1754	DNA topoisomerase type I activity
HCX60_RS21720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCX60_RS21725	COG0596	Alpha beta hydrolase
HCX60_RS21765	COG3629	intracellular signal transduction
HCX60_RS21765	COG3903	Transcriptional regulator
HCX60_RS21830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCX60_RS21830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCX60_RS21855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCX60_RS21860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCX60_RS21865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCX60_RS21870	COG0254	rRNA binding
HCX60_RS21880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCX60_RS21900	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS21910	COG0076	glutamate decarboxylase activity
HCX60_RS21920	COG0789	Transcriptional regulator
HCX60_RS21925	COG0393	Putative heavy-metal-binding
HCX60_RS21930	COG0586	Pfam SNARE associated Golgi protein
HCX60_RS21940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCX60_RS21945	COG2027	D-alanyl-D-alanine carboxypeptidase
HCX60_RS21955	COG0037	tRNA processing
HCX60_RS21970	COG0302	gtp cyclohydrolase
HCX60_RS21985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCX60_RS22000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCX60_RS22000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCX60_RS22025	COG0649	NAD binding
HCX60_RS22040	COG2197	response regulator
HCX60_RS22045	COG0640	Transcriptional regulator
HCX60_RS22060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCX60_RS22065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCX60_RS22075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCX60_RS22095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCX60_RS22125	COG0739	heme binding
HCX60_RS22140	COG2205	protein histidine kinase activity
HCX60_RS22145	COG0745	RESPONSE REGULATOR receiver
HCX60_RS22160	COG1194	a g-specific adenine glycosylase
HCX60_RS22170	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HCX60_RS22195	COG0248	Ppx GppA phosphatase
HCX60_RS22200	COG1082	Xylose isomerase domain protein TIM barrel
HCX60_RS22205	COG1309	transcriptional regulator
HCX60_RS22210	COG0129	dihydroxy-acid dehydratase activity
HCX60_RS22220	COG4991	sh3 domain protein
HCX60_RS22235	COG0842	Transport permease protein
HCX60_RS22235	COG1129	ABC transporter
HCX60_RS22245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCX60_RS22250	COG1335	isochorismatase
HCX60_RS22260	COG0180	Tryptophanyl-tRNA synthetase
HCX60_RS22280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCX60_RS22295	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCX60_RS22345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HCX60_RS22350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCX60_RS22355	COG0181	hydroxymethylbilane synthase activity
HCX60_RS22360	COG1648	precorrin-2 dehydrogenase activity
HCX60_RS22360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCX60_RS22370	COG0113	porphobilinogen synthase activity
HCX60_RS22395	COG0018	arginyl-trna synthetase
HCX60_RS22400	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HCX60_RS22420	COG1690	Belongs to the RtcB family
HCX60_RS22450	COG0701	Predicted permease
HCX60_RS22460	COG1733	regulation of RNA biosynthetic process
HCX60_RS22465	COG0604	alcohol dehydrogenase
HCX60_RS22470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS22485	COG2205	protein histidine kinase activity
HCX60_RS22490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS22510	COG2197	response regulator
HCX60_RS22575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCX60_RS22580	COG0406	alpha-ribazole phosphatase activity
HCX60_RS22590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCX60_RS22595	COG0785	Cytochrome C biogenesis protein
HCX60_RS22600	COG1333	cytochrome c biogenesis protein
HCX60_RS22605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCX60_RS22630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCX60_RS22635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HCX60_RS22640	COG0163	prenyltransferase activity
HCX60_RS22650	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCX60_RS22665	COG1309	transcriptional regulator
HCX60_RS22680	COG0183	Belongs to the thiolase family
HCX60_RS22755	COG3883	PFAM NLP P60 protein
HCX60_RS22755	COG0791	NLP P60 protein
HCX60_RS22775	COG3629	intracellular signal transduction
HCX60_RS22775	COG3903	Transcriptional regulator
HCX60_RS22825	COG2226	methyltransferase
HCX60_RS22850	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HCX60_RS22855	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS22855	COG0515	serine threonine protein kinase
HCX60_RS22865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCX60_RS22895	COG2226	methyltransferase
HCX60_RS22925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS22930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS22935	COG0649	NAD binding
HCX60_RS22945	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HCX60_RS22950	COG1034	ATP synthesis coupled electron transport
HCX60_RS22955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCX60_RS22960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS22965	COG0839	Belongs to the complex I subunit 6 family
HCX60_RS22970	COG0713	ATP synthesis coupled electron transport
HCX60_RS22975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCX60_RS22985	COG1007	ATP synthesis coupled electron transport
HCX60_RS22990	COG0514	ATP-dependent DNA helicase (RecQ)
HCX60_RS22995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCX60_RS23005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCX60_RS23020	COG2188	Transcriptional regulator
HCX60_RS23030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCX60_RS23060	COG0726	polysaccharide deacetylase
HCX60_RS23075	COG0561	phosphatase activity
HCX60_RS23095	COG1131	(ABC) transporter
HCX60_RS23135	COG0702	epimerase
HCX60_RS23140	COG1733	regulation of RNA biosynthetic process
HCX60_RS23145	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCX60_RS23150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCX60_RS23150	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCX60_RS23170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS23175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS23180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS23185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCX60_RS23190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCX60_RS23195	COG0839	Belongs to the complex I subunit 6 family
HCX60_RS23200	COG0713	ATP synthesis coupled electron transport
HCX60_RS23215	COG1007	ATP synthesis coupled electron transport
HCX60_RS23220	COG0501	Belongs to the peptidase M48B family
HCX60_RS23225	COG3304	Inner membrane component domain
HCX60_RS23240	COG2261	transglycosylase associated protein
HCX60_RS23245	COG1666	GTP binding
HCX60_RS23275	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCX60_RS23305	COG1674	ftsk spoiiie
HCX60_RS23350	COG0546	phosphoglycolate phosphatase activity
HCX60_RS23380	COG0402	S-adenosylhomocysteine deaminase activity
HCX60_RS23395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCX60_RS23400	COG2030	dehydratase
HCX60_RS23415	COG0477	Major facilitator Superfamily
HCX60_RS23420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCX60_RS23425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCX60_RS23430	COG0436	Aminotransferase
HCX60_RS23455	COG0081	regulation of translation
HCX60_RS23465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCX60_RS23470	COG0222	ribosome binding
HCX60_RS23475	COG0085	RNA polymerase activity
HCX60_RS23480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCX60_RS23495	COG0463	Glycosyl transferase, family 2
HCX60_RS23500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCX60_RS23505	COG0049	tRNA binding
HCX60_RS23510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCX60_RS23545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCX60_RS23555	COG0051	transcription antitermination factor activity, RNA binding
HCX60_RS23560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCX60_RS23565	COG0088	Forms part of the polypeptide exit tunnel
HCX60_RS23570	COG0089	rRNA binding
HCX60_RS23575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCX60_RS23580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCX60_RS23585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCX60_RS23590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCX60_RS23595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCX60_RS23600	COG0255	Belongs to the universal ribosomal protein uL29 family
HCX60_RS23605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCX60_RS23610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCX60_RS23615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCX60_RS23620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCX60_RS23625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCX60_RS23630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCX60_RS23635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCX60_RS23640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCX60_RS23645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCX60_RS23650	COG1841	ribosomal large subunit assembly
HCX60_RS23655	COG0200	Binds to the 23S rRNA
HCX60_RS23660	COG0201	protein transport
HCX60_RS23665	COG0563	adenylate kinase activity
HCX60_RS23680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCX60_RS23685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCX60_RS23690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCX60_RS23695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCX60_RS23700	COG0202	RNA polymerase activity
HCX60_RS23705	COG0203	ribosomal protein L17
HCX60_RS23710	COG0101	tRNA pseudouridine synthase activity
HCX60_RS23725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCX60_RS23730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCX60_RS23735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCX60_RS23740	COG1072	(Pantothenic acid kinase))
HCX60_RS23745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCX60_RS23760	COG0736	holo-[acyl-carrier-protein] synthase activity
HCX60_RS23770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCX60_RS23775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS23780	COG0802	atpase or kinase
HCX60_RS23805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCX60_RS23825	COG1316	TRANSCRIPTIONal
HCX60_RS23835	COG4941	Belongs to the sigma-70 factor family
HCX60_RS23845	COG0726	polysaccharide deacetylase
HCX60_RS23850	COG0726	polysaccharide deacetylase
HCX60_RS23855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCX60_RS23860	COG0459	protein refolding
HCX60_RS23880	COG4221	oxidoreductase activity
HCX60_RS23890	COG0583	DNA-binding transcription factor activity
HCX60_RS23905	COG1595	DNA-templated transcription, initiation
HCX60_RS23915	COG0516	GMP reductase activity
HCX60_RS23930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCX60_RS23955	COG0515	serine threonine protein kinase
HCX60_RS23960	COG0515	serine threonine protein kinase
HCX60_RS23965	COG0515	serine threonine protein kinase
HCX60_RS23970	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS23985	COG0519	Catalyzes the synthesis of GMP from XMP
HCX60_RS23985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCX60_RS24045	COG2197	response regulator
HCX60_RS24080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS24080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS24095	COG0714	Associated with various cellular activities
HCX60_RS24105	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HCX60_RS24110	COG0045	succinate-CoA ligase (ADP-forming) activity
HCX60_RS24130	COG1595	DNA-templated transcription, initiation
HCX60_RS24145	COG0138	bifunctional purine biosynthesis protein purh
HCX60_RS24160	COG2815	serine threonine protein kinase
HCX60_RS24160	COG0515	serine threonine protein kinase
HCX60_RS24170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCX60_RS24185	COG0039	L-malate dehydrogenase activity
HCX60_RS24190	COG0477	Major facilitator Superfamily
HCX60_RS24200	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS24210	COG4175	Glycine betaine
HCX60_RS24210	COG0517	IMP dehydrogenase activity
HCX60_RS24215	COG4176	ABC-type proline glycine betaine transport system permease component
HCX60_RS24225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS24240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCX60_RS24245	COG0180	Tryptophanyl-tRNA synthetase
HCX60_RS24265	COG0671	phosphoesterase, PA-phosphatase related
HCX60_RS24280	COG1295	ribonuclease BN
HCX60_RS24295	COG1408	metallophosphoesterase
HCX60_RS24300	COG1309	transcriptional regulator
HCX60_RS24350	COG2009	succinate dehydrogenase
HCX60_RS24360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCX60_RS24370	COG1595	DNA-templated transcription, initiation
HCX60_RS24390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS24390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS24415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCX60_RS24445	COG0463	Glycosyl transferase, family 2
HCX60_RS24455	COG1216	Glycosyl transferase, family 2
HCX60_RS24470	COG2089	acid synthase
HCX60_RS24500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HCX60_RS24500	COG1473	amidohydrolase
HCX60_RS24505	COG1744	ABC transporter substrate-binding protein PnrA-like
HCX60_RS24510	COG1744	ABC transporter substrate-binding protein PnrA-like
HCX60_RS24555	COG2814	Major facilitator Superfamily
HCX60_RS24560	COG0583	DNA-binding transcription factor activity
HCX60_RS24570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCX60_RS24595	COG2205	protein histidine kinase activity
HCX60_RS24600	COG0745	RESPONSE REGULATOR receiver
HCX60_RS24605	COG1595	DNA-templated transcription, initiation
HCX60_RS24620	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS24625	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS24630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCX60_RS24645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCX60_RS24675	COG4770	biotin carboxylase activity
HCX60_RS24685	COG0424	maF-like protein
HCX60_RS24695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCX60_RS24705	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HCX60_RS24715	COG1024	Enoyl-CoA hydratase
HCX60_RS24725	COG2986	histidine ammonia-lyase
HCX60_RS24755	COG1136	(ABC) transporter
HCX60_RS24765	COG1064	alcohol dehydrogenase
HCX60_RS24795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCX60_RS24815	COG2255	four-way junction helicase activity
HCX60_RS24820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCX60_RS24835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCX60_RS24845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCX60_RS24860	COG1331	Highly conserved protein containing a thioredoxin domain
HCX60_RS24890	COG1309	transcriptional regulator
HCX60_RS24895	COG0477	Major facilitator Superfamily
HCX60_RS24905	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HCX60_RS24920	COG0436	Aminotransferase
HCX60_RS24930	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HCX60_RS24945	COG1414	Transcriptional regulator
HCX60_RS24950	COG0251	oxidation-reduction process
HCX60_RS24985	COG1595	DNA-templated transcription, initiation
HCX60_RS25025	COG2894	cell division
HCX60_RS25060	COG2197	response regulator
HCX60_RS25080	COG2885	chlorophyll binding
HCX60_RS25095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCX60_RS25125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCX60_RS25130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCX60_RS25135	COG0741	lytic transglycosylase activity
HCX60_RS25150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS25155	COG0450	alkyl hydroperoxide reductase
HCX60_RS25185	COG1136	(ABC) transporter
HCX60_RS25205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCX60_RS25220	COG0114	fumarate hydratase activity
HCX60_RS25225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HCX60_RS25225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HCX60_RS25250	COG0778	Nitroreductase
HCX60_RS25255	COG1722	exodeoxyribonuclease VII activity
HCX60_RS25260	COG1570	exodeoxyribonuclease VII activity
HCX60_RS25265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCX60_RS25280	COG0012	GTP binding
HCX60_RS25315	COG2197	response regulator
HCX60_RS25320	COG4585	Histidine kinase
HCX60_RS25325	COG1309	transcriptional regulator
HCX60_RS25330	COG2409	Drug exporters of the RND superfamily
HCX60_RS25340	COG1271	oxidase subunit
HCX60_RS25400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCX60_RS25405	COG1053	succinate dehydrogenase
HCX60_RS25440	COG0601	transmembrane transport
HCX60_RS25445	COG0444	Belongs to the ABC transporter superfamily
HCX60_RS25450	COG4608	Belongs to the ABC transporter superfamily
HCX60_RS25465	COG0601	transmembrane transport
HCX60_RS25470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS25480	COG4608	Belongs to the ABC transporter superfamily
HCX60_RS25495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCX60_RS25510	COG1131	(ABC) transporter
HCX60_RS25520	COG4585	Histidine kinase
HCX60_RS25525	COG2197	response regulator
HCX60_RS25560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS25565	COG1611	Belongs to the LOG family
HCX60_RS25570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCX60_RS25580	COG0519	Catalyzes the synthesis of GMP from XMP
HCX60_RS25585	COG1024	Enoyl-CoA hydratase
HCX60_RS25600	COG1595	DNA-templated transcription, initiation
HCX60_RS25610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCX60_RS25615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCX60_RS25650	COG0598	Magnesium transport protein CorA
HCX60_RS25660	COG2814	Major facilitator Superfamily
HCX60_RS25675	COG2095	MarC family integral membrane protein
HCX60_RS25685	COG1432	Conserved Protein
HCX60_RS25695	COG0513	Belongs to the DEAD box helicase family
HCX60_RS25765	COG0596	Alpha beta hydrolase
HCX60_RS25770	COG0596	Alpha beta hydrolase
HCX60_RS25795	COG0210	DNA helicase
HCX60_RS25800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS25805	COG2816	NAD+ diphosphatase activity
HCX60_RS25840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HCX60_RS25895	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCX60_RS25905	COG1615	UPF0182 protein
HCX60_RS25935	COG0483	inositol monophosphate 1-phosphatase activity
HCX60_RS25950	COG1162	GTPase activity
HCX60_RS25955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCX60_RS25965	COG2135	peptidase activity
HCX60_RS25975	COG1595	DNA-templated transcription, initiation
HCX60_RS25980	COG5662	AntiSigma factor
HCX60_RS25985	COG2199	diguanylate cyclase activity
HCX60_RS25985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HCX60_RS26000	COG0242	peptide deformylase activity
HCX60_RS26010	COG2124	cytochrome p450
HCX60_RS26045	COG2188	Transcriptional regulator
HCX60_RS26050	COG2182	Extracellular solute-binding protein
HCX60_RS26055	COG1175	transmembrane transport
HCX60_RS26060	COG0395	ABC-type sugar transport system, permease component
HCX60_RS26065	COG1472	Belongs to the glycosyl hydrolase 3 family
HCX60_RS26070	COG0363	glucosamine-6-phosphate deaminase activity
HCX60_RS26085	COG1597	lipid kinase activity
HCX60_RS26115	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HCX60_RS26120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCX60_RS26155	COG4106	trans-aconitate 2-methyltransferase activity
HCX60_RS26160	COG1126	abc transporter atp-binding protein
HCX60_RS26175	COG0281	malic enzyme
HCX60_RS26180	COG0604	alcohol dehydrogenase
HCX60_RS26220	COG2205	protein histidine kinase activity
HCX60_RS26225	COG0745	RESPONSE REGULATOR receiver
HCX60_RS26235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCX60_RS26275	COG3883	PFAM NLP P60 protein
HCX60_RS26275	COG0791	NLP P60 protein
HCX60_RS26285	COG1309	transcriptional regulator
HCX60_RS26310	COG0768	penicillin binding
HCX60_RS26325	COG2205	protein histidine kinase activity
HCX60_RS26345	COG3285	dna ligase
HCX60_RS26345	COG1793	dna ligase
HCX60_RS26350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HCX60_RS26360	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS26375	COG0501	Belongs to the peptidase M48B family
HCX60_RS26385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCX60_RS26390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCX60_RS26395	COG1942	4-Oxalocrotonate Tautomerase
HCX60_RS26405	COG1605	Chorismate mutase
HCX60_RS26410	COG0512	Glutamine amidotransferase of anthranilate synthase
HCX60_RS26410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCX60_RS26415	COG0287	Prephenate dehydrogenase
HCX60_RS26420	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS26425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCX60_RS26445	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCX60_RS26475	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCX60_RS26485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HCX60_RS26490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCX60_RS26555	COG0556	nucleotide-excision repair
HCX60_RS26685	COG0018	arginyl-trna synthetase
HCX60_RS26685	COG0018	arginyl-trna synthetase
HCX60_RS26690	COG0019	diaminopimelate decarboxylase activity
HCX60_RS26695	COG0460	homoserine dehydrogenase
HCX60_RS26700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCX60_RS26705	COG0083	homoserine kinase activity
HCX60_RS26725	COG0254	rRNA binding
HCX60_RS26730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCX60_RS26735	COG2890	protein-(glutamine-N5) methyltransferase activity
HCX60_RS26745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS26750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCX60_RS26755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCX60_RS26775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCX60_RS26780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCX60_RS26785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCX60_RS26790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCX60_RS26795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCX60_RS26800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCX60_RS26805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCX60_RS26820	COG2197	response regulator
HCX60_RS26850	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HCX60_RS26885	COG1131	(ABC) transporter
HCX60_RS26900	COG0346	lactoylglutathione lyase activity
HCX60_RS26905	COG0183	Belongs to the thiolase family
HCX60_RS26925	COG2205	protein histidine kinase activity
HCX60_RS27000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS27000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS27035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCX60_RS27040	COG0857	belongs to the CobB CobQ family
HCX60_RS27040	COG0280	phosphate acetyltransferase
HCX60_RS27045	COG0205	6-phosphofructokinase activity
HCX60_RS27055	COG4565	transcriptional regulatory protein
HCX60_RS27060	COG3290	protein histidine kinase activity
HCX60_RS27065	COG1301	dicarboxylic acid transport
HCX60_RS27070	COG0667	Aldo Keto reductase
HCX60_RS27080	COG1522	sequence-specific DNA binding
HCX60_RS27100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCX60_RS27105	COG3281	Trehalose synthase
HCX60_RS27110	COG0366	Alpha amylase catalytic
HCX60_RS27115	COG0366	Alpha amylase catalytic
HCX60_RS27125	COG0058	SHG alpha-glucan phosphorylase activity
HCX60_RS27150	COG1132	(ABC) transporter
HCX60_RS27155	COG1132	(ABC) transporter
HCX60_RS27165	COG1376	ErfK ybiS ycfS ynhG family protein
HCX60_RS27170	COG1376	ErfK ybiS ycfS ynhG family protein
HCX60_RS27205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCX60_RS27210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCX60_RS27225	COG1760	l-serine dehydratase
HCX60_RS27230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCX60_RS27235	COG0509	glycine decarboxylation via glycine cleavage system
HCX60_RS27240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCX60_RS27275	COG0444	Belongs to the ABC transporter superfamily
HCX60_RS27280	COG4608	Belongs to the ABC transporter superfamily
HCX60_RS27285	COG2860	membrane
HCX60_RS27315	COG3023	N-Acetylmuramoyl-L-alanine amidase
HCX60_RS27320	COG0482	sulfurtransferase activity
HCX60_RS27340	COG4221	oxidoreductase activity
HCX60_RS27350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCX60_RS27360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCX60_RS27365	COG0154	amidase activity
HCX60_RS27375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCX60_RS27385	COG2409	Drug exporters of the RND superfamily
HCX60_RS27390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCX60_RS27405	COG1672	PFAM Archaeal ATPase
HCX60_RS27405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HCX60_RS27410	COG2133	pyrroloquinoline quinone binding
HCX60_RS27415	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HCX60_RS27420	COG1396	sequence-specific DNA binding
HCX60_RS27425	COG0667	Aldo Keto reductase
HCX60_RS27440	COG5001	Diguanylate cyclase
HCX60_RS27450	COG0440	acetolactate synthase activity
HCX60_RS27455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCX60_RS27465	COG0477	Major facilitator Superfamily
HCX60_RS27480	COG3835	regulator
HCX60_RS27485	COG0506	proline dehydrogenase activity
HCX60_RS27490	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS27495	COG0473	3-isopropylmalate dehydrogenase activity
HCX60_RS27500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCX60_RS27510	COG0832	Belongs to the urease beta subunit family
HCX60_RS27510	COG0831	urea catabolic process
HCX60_RS27515	COG0804	urea catabolic process
HCX60_RS27520	COG2957	Belongs to the agmatine deiminase family
HCX60_RS27530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCX60_RS27540	COG1472	Belongs to the glycosyl hydrolase 3 family
HCX60_RS27570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCX60_RS27590	COG2018	Roadblock/LC7 domain
HCX60_RS27610	COG2018	Roadblock/LC7 domain
HCX60_RS27625	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCX60_RS27630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCX60_RS27675	COG1414	Transcriptional regulator
HCX60_RS27680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCX60_RS27685	COG0066	3-isopropylmalate dehydratase activity
HCX60_RS27695	COG0776	regulation of translation
HCX60_RS27705	COG1920	GTP binding
HCX60_RS27715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCX60_RS27720	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCX60_RS27740	COG0351	phosphomethylpyrimidine kinase
HCX60_RS27745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCX60_RS27750	COG1461	Dihydroxyacetone kinase
HCX60_RS27760	COG0326	Molecular chaperone. Has ATPase activity
HCX60_RS27765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCX60_RS27770	COG0742	ribosomal rna small subunit methyltransferase
HCX60_RS27775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCX60_RS27790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCX60_RS27795	COG0571	ribonuclease III activity
HCX60_RS27800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCX60_RS27805	COG1733	regulation of RNA biosynthetic process
HCX60_RS27810	COG2340	Cysteine-rich secretory protein family
HCX60_RS27815	COG1254	Belongs to the acylphosphatase family
HCX60_RS27830	COG0477	Major facilitator Superfamily
HCX60_RS27875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCX60_RS27885	COG0442	prolyl-tRNA aminoacylation
HCX60_RS27895	COG0228	four-way junction DNA binding
HCX60_RS27900	COG1837	Belongs to the UPF0109 family
HCX60_RS27905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCX60_RS27910	COG0336	Belongs to the RNA methyltransferase TrmD family
HCX60_RS27915	COG0335	large ribosomal subunit rRNA binding
HCX60_RS27930	COG0681	Belongs to the peptidase S26 family
HCX60_RS27935	COG0681	Belongs to the peptidase S26 family
HCX60_RS27950	COG0792	nuclease activity
HCX60_RS27965	COG1191	sigma factor activity
HCX60_RS27980	COG0052	Belongs to the universal ribosomal protein uS2 family
HCX60_RS27985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCX60_RS27990	COG0528	UMP kinase activity
HCX60_RS27995	COG0233	cytoplasmic translational termination
HCX60_RS28000	COG0575	Belongs to the CDS family
HCX60_RS28095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCX60_RS28105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HCX60_RS28110	COG3842	ATPase activity
HCX60_RS28135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCX60_RS28145	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS28205	COG0584	glycerophosphoryl diester phosphodiesterase
HCX60_RS28210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HCX60_RS28235	COG3842	ATPase activity
HCX60_RS28240	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCX60_RS28245	COG1177	transmembrane transport
HCX60_RS28250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCX60_RS28260	COG2508	Transcriptional regulator
HCX60_RS28280	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS28295	COG4209	transmembrane transport
HCX60_RS28300	COG0395	ABC-type sugar transport system, permease component
HCX60_RS28340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCX60_RS28345	COG0750	zinc metalloprotease
HCX60_RS28350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCX60_RS28365	COG0442	prolyl-tRNA aminoacylation
HCX60_RS28420	COG0779	Required for maturation of 30S ribosomal subunits
HCX60_RS28445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCX60_RS28450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCX60_RS28465	COG0455	bacterial-type flagellum organization
HCX60_RS28480	COG3266	domain, Protein
HCX60_RS28485	COG1404	Belongs to the peptidase S8 family
HCX60_RS28540	COG1404	Belongs to the peptidase S8 family
HCX60_RS28570	COG1674	ftsk spoiiie
HCX60_RS28590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCX60_RS28595	COG1185	polyribonucleotide nucleotidyltransferase activity
HCX60_RS28600	COG0612	Peptidase, M16
HCX60_RS28605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCX60_RS28620	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HCX60_RS28625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS28630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCX60_RS28660	COG2208	phosphoserine phosphatase activity
HCX60_RS28660	COG2770	Histidine kinase
HCX60_RS28670	COG4999	Histidine kinase
HCX60_RS28670	COG3850	Histidine kinase
HCX60_RS28670	COG3437	response regulator, receiver
HCX60_RS28670	COG2205	protein histidine kinase activity
HCX60_RS28680	COG1674	ftsk spoiiie
HCX60_RS28690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCX60_RS28700	COG1058	Belongs to the CinA family
HCX60_RS28700	COG1546	Belongs to the CinA family
HCX60_RS28705	COG1396	sequence-specific DNA binding
HCX60_RS28715	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS28720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCX60_RS28725	COG1201	RNA secondary structure unwinding
HCX60_RS28730	COG1917	Cupin 2, conserved barrel domain protein
HCX60_RS28730	COG2207	Transcriptional regulator
HCX60_RS28765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCX60_RS28775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCX60_RS28785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCX60_RS28790	COG0765	amino acid transport
HCX60_RS28795	COG0765	amino acid transport
HCX60_RS28800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCX60_RS28805	COG1126	abc transporter atp-binding protein
HCX60_RS28810	COG0745	RESPONSE REGULATOR receiver
HCX60_RS28815	COG2205	protein histidine kinase activity
HCX60_RS28850	COG2197	response regulator
HCX60_RS28855	COG0436	Aminotransferase
HCX60_RS28875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCX60_RS28895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCX60_RS28905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCX60_RS28925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCX60_RS28955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCX60_RS28960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCX60_RS28965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCX60_RS28980	COG0588	phosphoglycerate mutase activity
HCX60_RS28990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCX60_RS29005	COG0514	ATP-dependent DNA helicase (RecQ)
HCX60_RS29025	COG1131	(ABC) transporter
HCX60_RS29030	COG2186	Transcriptional regulator
HCX60_RS29035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCX60_RS29050	COG0187	DNA topoisomerase II activity
HCX60_RS29065	COG2197	response regulator
HCX60_RS29075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCX60_RS29080	COG4565	transcriptional regulatory protein
HCX60_RS29085	COG3290	protein histidine kinase activity
HCX60_RS29110	COG0523	cobalamin synthesis protein
HCX60_RS29115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCX60_RS29120	COG0612	Peptidase, M16
HCX60_RS29135	COG1802	Transcriptional regulator
HCX60_RS29140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCX60_RS29170	COG1435	thymidine kinase activity
HCX60_RS29225	COG0745	RESPONSE REGULATOR receiver
HCX60_RS29230	COG2205	protein histidine kinase activity
HCX60_RS29255	COG0756	dUTP diphosphatase activity
HCX60_RS29290	COG0569	domain protein
HCX60_RS29295	COG0531	amino acid
HCX60_RS29300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCX60_RS29395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCX60_RS29420	COG1799	cell septum assembly
HCX60_RS29445	COG0583	DNA-binding transcription factor activity
HCX60_RS29450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCX60_RS29455	COG0300	oxidoreductase activity
HCX60_RS29470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCX60_RS29485	COG2235	arginine
HCX60_RS29490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCX60_RS29500	COG1024	Enoyl-CoA hydratase
HCX60_RS29545	COG0443	Heat shock 70 kDa protein
HCX60_RS29590	COG2175	clavaminate synthase activity
HCX60_RS29610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCX60_RS29620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCX60_RS29635	COG1653	transport
HCX60_RS29640	COG1175	transmembrane transport
HCX60_RS29645	COG0395	ABC-type sugar transport system, permease component
HCX60_RS29650	COG1940	carbohydrate kinase activity
HCX60_RS29655	COG4213	ABC transporter substrate-binding protein
HCX60_RS29665	COG4214	carbohydrate transport
HCX60_RS29670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCX60_RS29675	COG0531	amino acid
HCX60_RS29690	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCX60_RS29690	COG1024	Enoyl-CoA hydratase
HCX60_RS29695	COG0183	Belongs to the thiolase family
HCX60_RS29700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HCX60_RS29715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCX60_RS29745	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCX60_RS29780	COG3220	belongs to the UPF0276 family
HCX60_RS29805	COG0330	HflC and HflK could
HCX60_RS29840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCX60_RS29845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCX60_RS29855	COG2205	protein histidine kinase activity
HCX60_RS29860	COG0745	RESPONSE REGULATOR receiver
HCX60_RS29880	COG1174	glycine betaine transport
HCX60_RS29885	COG1174	glycine betaine transport
HCX60_RS29900	COG2018	Roadblock/LC7 domain
HCX60_RS29905	COG5002	protein histidine kinase activity
HCX60_RS29915	COG2986	histidine ammonia-lyase
HCX60_RS29920	COG2755	lipolytic protein G-D-S-L family
HCX60_RS29930	COG0642	Histidine kinase
HCX60_RS29965	COG1404	Belongs to the peptidase S8 family
HCX60_RS29980	COG1309	transcriptional regulator
HCX60_RS30000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCX60_RS30010	COG3173	Aminoglycoside phosphotransferase
HCX60_RS30115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCX60_RS30120	COG1116	anion transmembrane transporter activity
HCX60_RS30145	COG0529	Catalyzes the synthesis of activated sulfate
HCX60_RS30150	COG0175	sulfate reduction
HCX60_RS30180	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS30195	COG1917	Cupin 2, conserved barrel domain protein
HCX60_RS30195	COG4977	sequence-specific DNA binding
HCX60_RS30255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCX60_RS30265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCX60_RS30275	COG2040	homocysteine
HCX60_RS30285	COG2755	lipolytic protein G-D-S-L family
HCX60_RS30350	COG0395	ABC-type sugar transport system, permease component
HCX60_RS30355	COG1175	transmembrane transport
HCX60_RS30370	COG0277	FAD linked oxidase domain protein
HCX60_RS30380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HCX60_RS30385	COG1162	GTPase activity
HCX60_RS30395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCX60_RS30415	COG0028	Belongs to the TPP enzyme family
HCX60_RS30445	COG1802	Transcriptional regulator
HCX60_RS30455	COG3835	regulator
HCX60_RS30470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCX60_RS30475	COG2252	PERMEase
HCX60_RS30495	COG3940	Belongs to the glycosyl hydrolase 43 family
HCX60_RS30505	COG1122	ATPase activity
HCX60_RS30510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCX60_RS30515	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HCX60_RS30520	COG0310	cobalt ion transport
HCX60_RS30525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCX60_RS30545	COG2197	response regulator
HCX60_RS30550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCX60_RS30555	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS30565	COG3960	tartronate-semialdehyde synthase activity
HCX60_RS30605	COG2084	Dehydrogenase
HCX60_RS30610	COG3622	Belongs to the hyi family
HCX60_RS30630	COG2351	hydroxyisourate hydrolase activity
HCX60_RS30650	COG1733	regulation of RNA biosynthetic process
HCX60_RS30665	COG0406	alpha-ribazole phosphatase activity
HCX60_RS30670	COG0436	Aminotransferase
HCX60_RS30675	COG1733	regulation of RNA biosynthetic process
HCX60_RS30690	COG4264	IucA IucC family
HCX60_RS30730	COG1414	Transcriptional regulator
HCX60_RS30735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCX60_RS30740	COG4266	Belongs to the allantoicase family
HCX60_RS30765	COG0515	serine threonine protein kinase
HCX60_RS30770	COG0477	Major facilitator Superfamily
HCX60_RS30795	COG1024	Enoyl-CoA hydratase
HCX60_RS30820	COG0702	epimerase
HCX60_RS30825	COG3903	Transcriptional regulator
HCX60_RS30825	COG2197	response regulator
HCX60_RS30840	COG4251	negative regulation of phosphorylation
HCX60_RS30845	COG0784	Response regulator, receiver
HCX60_RS30860	COG2197	response regulator
HCX60_RS30865	COG0673	inositol 2-dehydrogenase activity
HCX60_RS30870	COG2188	Transcriptional regulator
HCX60_RS30875	COG1940	carbohydrate kinase activity
HCX60_RS30905	COG1017	nitric oxide dioxygenase activity
HCX60_RS30905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCX60_RS30965	COG1140	nitrate reductase beta subunit
HCX60_RS30985	COG2132	Multicopper oxidase
HCX60_RS31020	COG1140	nitrate reductase beta subunit
HCX60_RS31025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCX60_RS31040	COG2273	Hydrolase Family 16
HCX60_RS31045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS31050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCX60_RS31075	COG0405	Gamma-glutamyltransferase
HCX60_RS31080	COG0542	response to heat
HCX60_RS31105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCX60_RS31120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCX60_RS31130	COG1953	Uracil, thiamine, allantoin
HCX60_RS31140	COG0483	inositol monophosphate 1-phosphatase activity
HCX60_RS31175	COG0604	alcohol dehydrogenase
HCX60_RS31180	COG0318	PFAM AMP-dependent synthetase and ligase
HCX60_RS31185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCX60_RS31190	COG3396	Phenylacetate-CoA oxygenase
HCX60_RS31195	COG3460	Phenylacetate-CoA oxygenase
HCX60_RS31200	COG3396	Phenylacetate-CoA oxygenase
HCX60_RS31205	COG2151	metal-sulfur cluster biosynthetic enzyme
HCX60_RS31210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCX60_RS31215	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS31220	COG3483	tryptophan 2,3-dioxygenase activity
HCX60_RS31230	COG3844	kynureninase activity
HCX60_RS31240	COG0243	molybdopterin cofactor binding
HCX60_RS31275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCX60_RS31285	COG0494	nUDIX hydrolase
HCX60_RS31295	COG1929	Belongs to the glycerate kinase type-1 family
HCX60_RS31305	COG0688	phosphatidylethanolamine metabolic process
HCX60_RS31310	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS31325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS31325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCX60_RS31330	COG0604	alcohol dehydrogenase
HCX60_RS31340	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCX60_RS31360	COG0596	Alpha beta hydrolase
HCX60_RS31385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCX60_RS31400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS31405	COG2362	D-Aminopeptidase
HCX60_RS31410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCX60_RS31420	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCX60_RS31430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCX60_RS31460	COG2226	methyltransferase
HCX60_RS31470	COG0488	(ABC) transporter
HCX60_RS31560	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCX60_RS31565	COG2226	methyltransferase
HCX60_RS31580	COG2378	regulation of single-species biofilm formation
HCX60_RS31585	COG5297	Belongs to the glycosyl hydrolase family 6
HCX60_RS31595	COG0656	L-ascorbic acid biosynthetic process
HCX60_RS31615	COG1335	isochorismatase
HCX60_RS31620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCX60_RS31635	COG3383	formate dehydrogenase (NAD+) activity
HCX60_RS31640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCX60_RS31655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCX60_RS31665	COG2223	nitrite transmembrane transporter activity
HCX60_RS31675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HCX60_RS31685	COG0045	succinate-CoA ligase (ADP-forming) activity
HCX60_RS31695	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS31725	COG2124	cytochrome p450
HCX60_RS31735	COG2072	flavoprotein involved in K transport
HCX60_RS31745	COG3938	Belongs to the proline racemase family
HCX60_RS31750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCX60_RS31775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCX60_RS31785	COG2182	Extracellular solute-binding protein
HCX60_RS31790	COG1175	transmembrane transport
HCX60_RS31795	COG0395	ABC-type sugar transport system, permease component
HCX60_RS31800	COG2723	6-phospho-beta-galactosidase activity
HCX60_RS31805	COG2273	Hydrolase Family 16
HCX60_RS31845	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS31860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCX60_RS31885	COG0477	Major facilitator Superfamily
HCX60_RS31895	COG3467	pyridoxamine 5'-phosphate
HCX60_RS31915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HCX60_RS31920	COG0166	Belongs to the GPI family
HCX60_RS31935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCX60_RS31955	COG1486	melibiose metabolic process
HCX60_RS32070	COG0322	excinuclease ABC activity
HCX60_RS32185	COG1674	ftsk spoiiie
HCX60_RS32370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS32405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS32485	COG3469	chitinase activity
HCX60_RS32530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCX60_RS32550	COG0702	epimerase
HCX60_RS32585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCX60_RS32590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS32600	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS32615	COG3511	phospholipase C
HCX60_RS32650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS32655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCX60_RS32660	COG3485	protocatechuate 3,4-dioxygenase
HCX60_RS32665	COG3485	protocatechuate 3,4-dioxygenase
HCX60_RS32670	COG0183	Belongs to the thiolase family
HCX60_RS32685	COG1846	Transcriptional regulator
HCX60_RS32700	COG1793	dna ligase
HCX60_RS32730	COG1834	amidinotransferase
HCX60_RS32735	COG0488	(ABC) transporter
HCX60_RS32760	COG1515	deoxyribonuclease V activity
HCX60_RS32765	COG3268	Saccharopine dehydrogenase
HCX60_RS32780	COG0183	Belongs to the thiolase family
HCX60_RS32785	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCX60_RS32785	COG1024	Enoyl-CoA hydratase
HCX60_RS32795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCX60_RS32805	COG2936	dipeptidyl-peptidase activity
HCX60_RS32815	COG0488	(ABC) transporter
HCX60_RS32820	COG2183	response to ionizing radiation
HCX60_RS32825	COG1024	Enoyl-CoA hydratase
HCX60_RS32835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCX60_RS32880	COG1134	teichoic acid transport
HCX60_RS32885	COG1562	ergosterol biosynthetic process
HCX60_RS32895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HCX60_RS32905	COG1657	PFAM Prenyltransferase squalene oxidase
HCX60_RS32920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCX60_RS32925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCX60_RS32960	COG2755	lipolytic protein G-D-S-L family
HCX60_RS32975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCX60_RS33010	COG1063	alcohol dehydrogenase
HCX60_RS33015	COG0156	8-amino-7-oxononanoate synthase activity
HCX60_RS33020	COG0583	DNA-binding transcription factor activity
HCX60_RS33065	COG0174	glutamine synthetase
HCX60_RS33070	COG0561	phosphatase activity
HCX60_RS33075	COG1473	amidohydrolase
HCX60_RS33085	COG2267	carboxylic ester hydrolase activity
HCX60_RS33095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCX60_RS33125	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS33135	COG2188	Transcriptional regulator
HCX60_RS33155	COG0673	inositol 2-dehydrogenase activity
HCX60_RS33160	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS33170	COG1609	Transcriptional regulator
HCX60_RS33190	COG1819	glycosyl
HCX60_RS33210	COG3321	synthase
HCX60_RS33210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS33260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33285	COG2197	response regulator
HCX60_RS33295	COG1404	Belongs to the peptidase S8 family
HCX60_RS33320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCX60_RS33330	COG2838	Isocitrate dehydrogenase
HCX60_RS33340	COG0668	transmembrane transport
HCX60_RS33350	COG1132	(ABC) transporter
HCX60_RS33370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS33370	COG0515	serine threonine protein kinase
HCX60_RS33380	COG2133	pyrroloquinoline quinone binding
HCX60_RS33390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCX60_RS33420	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCX60_RS33425	COG2318	DinB family
HCX60_RS33455	COG1408	metallophosphoesterase
HCX60_RS33490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCX60_RS33505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCX60_RS33525	COG0297	glycogen (starch) synthase activity
HCX60_RS33530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCX60_RS33555	COG0154	amidase activity
HCX60_RS33575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCX60_RS33620	COG0726	polysaccharide deacetylase
HCX60_RS33665	COG0583	DNA-binding transcription factor activity
HCX60_RS33675	COG1053	succinate dehydrogenase
HCX60_RS33680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCX60_RS33700	COG0542	response to heat
HCX60_RS33705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33715	COG3360	Dodecin
HCX60_RS33720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCX60_RS33725	COG0110	maltose O-acetyltransferase activity
HCX60_RS33730	COG0438	transferase activity, transferring glycosyl groups
HCX60_RS33740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCX60_RS33775	COG5434	Belongs to the glycosyl hydrolase 28 family
HCX60_RS33780	COG2045	Belongs to the ComB family
HCX60_RS33785	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HCX60_RS33790	COG0121	glutamine amidotransferase
HCX60_RS33795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCX60_RS33815	COG2268	Band 7 protein
HCX60_RS33845	COG2814	Major facilitator Superfamily
HCX60_RS33865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS33880	COG1609	Transcriptional regulator
HCX60_RS33890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCX60_RS33900	COG0242	peptide deformylase activity
HCX60_RS33980	COG1556	Lactate utilization protein
HCX60_RS33985	COG1139	Iron-sulfur cluster binding protein
HCX60_RS33990	COG0247	lactate metabolic process
HCX60_RS33995	COG1070	Carbohydrate kinase
HCX60_RS34000	COG3347	Dehydrogenase
HCX60_RS34000	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS34005	COG4952	isomerase
HCX60_RS34010	COG1129	ABC transporter
HCX60_RS34040	COG1609	Transcriptional regulator
HCX60_RS34070	COG1357	PFAM Pentapeptide repeats (8 copies)
HCX60_RS34075	COG2124	cytochrome p450
HCX60_RS34075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCX60_RS34080	COG1309	transcriptional regulator
HCX60_RS34090	COG2706	6-phosphogluconolactonase activity
HCX60_RS34115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCX60_RS34115	COG1796	DNA polymerase
HCX60_RS34135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCX60_RS34175	COG0531	amino acid
HCX60_RS34200	COG0435	Glutathione S-transferase
HCX60_RS34215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCX60_RS34225	COG0667	Aldo Keto reductase
HCX60_RS34290	COG2274	protein secretion by the type I secretion system
HCX60_RS34355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HCX60_RS34395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS34460	COG0174	glutamine synthetase
HCX60_RS34475	COG4689	acetoacetate decarboxylase
HCX60_RS34495	COG1309	transcriptional regulator
HCX60_RS34505	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS34510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCX60_RS34515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCX60_RS34520	COG1846	Transcriptional regulator
HCX60_RS34580	COG2409	Drug exporters of the RND superfamily
HCX60_RS34595	COG0673	inositol 2-dehydrogenase activity
HCX60_RS34605	COG2197	response regulator
HCX60_RS34610	COG2508	Transcriptional regulator
HCX60_RS34615	COG0410	ABC transporter
HCX60_RS34620	COG0411	ABC transporter
HCX60_RS34625	COG0559	Belongs to the binding-protein-dependent transport system permease family
HCX60_RS34640	COG1132	(ABC) transporter
HCX60_RS34675	COG2207	Transcriptional regulator
HCX60_RS34680	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS34700	COG0596	Alpha beta hydrolase
HCX60_RS34725	COG3290	protein histidine kinase activity
HCX60_RS34755	COG1597	lipid kinase activity
HCX60_RS34765	COG2264	protein methyltransferase activity
HCX60_RS34800	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HCX60_RS34805	COG0714	Associated with various cellular activities
HCX60_RS34830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HCX60_RS34870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCX60_RS34890	COG0395	ABC-type sugar transport system, permease component
HCX60_RS35005	COG1120	ATPase activity
HCX60_RS35010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS35015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS35020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS35030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCX60_RS35035	COG1132	(ABC) transporter
HCX60_RS35040	COG1132	(ABC) transporter
HCX60_RS35050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCX60_RS35050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCX60_RS35065	COG0515	serine threonine protein kinase
HCX60_RS35065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCX60_RS35125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCX60_RS35135	COG0243	molybdopterin cofactor binding
HCX60_RS35155	COG1120	ATPase activity
HCX60_RS35185	COG4977	sequence-specific DNA binding
HCX60_RS35210	COG0747	negative chemotaxis
HCX60_RS35220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS35225	COG0444	Belongs to the ABC transporter superfamily
HCX60_RS35230	COG4608	Belongs to the ABC transporter superfamily
HCX60_RS35235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS35240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCX60_RS35250	COG0431	NADPH-dependent FMN reductase
HCX60_RS35290	COG2223	nitrite transmembrane transporter activity
HCX60_RS35320	COG1959	2 iron, 2 sulfur cluster binding
HCX60_RS35335	COG3469	chitinase activity
HCX60_RS35345	COG3973	AAA domain
HCX60_RS35355	COG2050	protein possibly involved in aromatic compounds catabolism
HCX60_RS35360	COG0183	Belongs to the thiolase family
HCX60_RS35365	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCX60_RS35375	COG3460	Phenylacetate-CoA oxygenase
HCX60_RS35380	COG3396	Phenylacetate-CoA oxygenase
HCX60_RS35385	COG2151	metal-sulfur cluster biosynthetic enzyme
HCX60_RS35390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCX60_RS35395	COG2259	Doxx family
HCX60_RS35410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCX60_RS35415	COG4638	Rieske (2fe-2S)
HCX60_RS35425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCX60_RS35430	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS35435	COG0517	IMP dehydrogenase activity
HCX60_RS35435	COG4175	Glycine betaine
HCX60_RS35440	COG4176	ABC-type proline glycine betaine transport system permease component
HCX60_RS35515	COG1132	(ABC) transporter
HCX60_RS35520	COG1132	(ABC) transporter
HCX60_RS35530	COG1120	ATPase activity
HCX60_RS35535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS35540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCX60_RS35545	COG4753	response regulator
HCX60_RS35545	COG2207	Transcriptional regulator
HCX60_RS35620	COG0477	Major facilitator Superfamily
HCX60_RS35625	COG0745	RESPONSE REGULATOR receiver
HCX60_RS35630	COG4251	negative regulation of phosphorylation
HCX60_RS35635	COG0784	Response regulator, receiver
HCX60_RS35640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCX60_RS35645	COG2226	methyltransferase
HCX60_RS35655	COG1278	Cold shock
HCX60_RS35675	COG1295	ribonuclease BN
HCX60_RS35700	COG0277	FAD linked oxidase domain protein
HCX60_RS35705	COG1597	lipid kinase activity
HCX60_RS35715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCX60_RS35735	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HCX60_RS35755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCX60_RS35765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCX60_RS35780	COG1309	transcriptional regulator
HCX60_RS35785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCX60_RS35790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCX60_RS35795	COG1733	regulation of RNA biosynthetic process
HCX60_RS35805	COG0346	lactoylglutathione lyase activity
HCX60_RS35810	COG0726	polysaccharide deacetylase
HCX60_RS35820	COG2130	NADP-dependent
HCX60_RS35825	COG0583	DNA-binding transcription factor activity
HCX60_RS35830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HCX60_RS35840	COG0395	ABC-type sugar transport system, permease component
HCX60_RS35845	COG1175	transmembrane transport
HCX60_RS35850	COG2182	Extracellular solute-binding protein
HCX60_RS35855	COG2188	Transcriptional regulator
HCX60_RS35875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCX60_RS35880	COG0067	glutamate synthase
HCX60_RS35880	COG0070	glutamate synthase
HCX60_RS35880	COG0069	glutamate synthase activity
HCX60_RS35895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCX60_RS35895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCX60_RS35905	COG2197	response regulator
HCX60_RS35935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCX60_RS35940	COG4521	taurine ABC transporter
HCX60_RS35945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HCX60_RS35950	COG2175	clavaminate synthase activity
HCX60_RS35960	COG4172	Belongs to the ABC transporter superfamily
HCX60_RS35965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCX60_RS35990	COG4948	Mandelate Racemase Muconate Lactonizing
HCX60_RS35995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCX60_RS36005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCX60_RS36010	COG2226	methyltransferase
HCX60_RS36030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCX60_RS36065	COG1045	serine acetyltransferase
HCX60_RS36120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCX60_RS36140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCX60_RS36160	COG0640	Transcriptional regulator
HCX60_RS36190	COG0659	secondary active sulfate transmembrane transporter activity
HCX60_RS36195	COG2824	Alkylphosphonate utilization operon protein PhnA
HCX60_RS36220	COG2255	four-way junction helicase activity
HCX60_RS36225	COG1230	cation diffusion facilitator family transporter
HCX60_RS36290	COG3864	Putative metallopeptidase domain
HCX60_RS36295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCX60_RS36305	COG0431	NADPH-dependent FMN reductase
HCX60_RS36335	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS36345	COG4585	Histidine kinase
HCX60_RS36350	COG2197	response regulator
HCX60_RS36365	COG2072	flavoprotein involved in K transport
HCX60_RS36370	COG1309	transcriptional regulator
HCX60_RS36500	COG0517	IMP dehydrogenase activity
HCX60_RS36500	COG0516	GMP reductase activity
HCX60_RS36525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCX60_RS36530	COG1042	CoA-binding domain protein
HCX60_RS36530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCX60_RS36530	COG0045	succinate-CoA ligase (ADP-forming) activity
HCX60_RS36540	COG1063	alcohol dehydrogenase
HCX60_RS36550	COG4716	Myosin-crossreactive antigen
HCX60_RS36555	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS36555	COG1454	alcohol dehydrogenase
HCX60_RS36560	COG0517	IMP dehydrogenase activity
HCX60_RS36565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCX60_RS36565	COG0574	Belongs to the PEP-utilizing enzyme family
HCX60_RS36570	COG2239	Acts as a magnesium transporter
HCX60_RS36600	COG2046	Belongs to the sulfate adenylyltransferase family
HCX60_RS36600	COG0529	Catalyzes the synthesis of activated sulfate
HCX60_RS36695	COG0402	S-adenosylhomocysteine deaminase activity
HCX60_RS36710	COG1501	Belongs to the glycosyl hydrolase 31 family
HCX60_RS36725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCX60_RS36730	COG3537	Alpha-1,2-mannosidase
HCX60_RS36735	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS36745	COG2508	Transcriptional regulator
HCX60_RS36775	COG2318	DinB family
HCX60_RS36825	COG0395	ABC-type sugar transport system, permease component
HCX60_RS36840	COG2723	6-phospho-beta-galactosidase activity
HCX60_RS36870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HCX60_RS36875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HCX60_RS36880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HCX60_RS36910	COG0697	spore germination
HCX60_RS36925	COG2353	YceI-like domain
HCX60_RS36930	COG1028	Short-chain dehydrogenase reductase Sdr
HCX60_RS36955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCX60_RS36990	COG2124	cytochrome p450
HCX60_RS37005	COG3483	tryptophan 2,3-dioxygenase activity
HCX60_RS37025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCX60_RS37040	COG3251	PFAM MbtH domain protein
HCX60_RS37060	COG0666	response to abiotic stimulus
HCX60_RS37065	COG1280	lysine exporter protein (LysE YggA)
HCX60_RS37095	COG3655	Transcriptional regulator
HCX60_RS37130	COG2318	DinB family
HCX60_RS37135	COG2084	Dehydrogenase
HCX60_RS37140	COG0789	Transcriptional regulator
HCX60_RS37150	COG0300	oxidoreductase activity
HCX60_RS37165	COG0300	oxidoreductase activity
HCX60_RS37170	COG1309	transcriptional regulator
HCX60_RS37180	COG2207	Transcriptional regulator
HCX60_RS37180	COG3708	Transcriptional regulator
HCX60_RS37185	COG0367	asparagine synthase
HCX60_RS37190	COG0183	Belongs to the thiolase family
HCX60_RS37230	COG0583	DNA-binding transcription factor activity
HCX60_RS37285	COG2259	Doxx family
HCX60_RS37300	COG1473	amidohydrolase
HCX60_RS37415	COG1609	Transcriptional regulator
HCX60_RS37425	COG1175	transmembrane transport
HCX60_RS37435	COG1472	Belongs to the glycosyl hydrolase 3 family
HCX60_RS37450	COG2235	arginine
HCX60_RS37465	COG3896	Chloramphenicol phosphotransferase-like protein
HCX60_RS37470	COG1228	amidohydrolase
HCX60_RS37475	COG0726	polysaccharide deacetylase
HCX60_RS37485	COG2205	protein histidine kinase activity
HCX60_RS37490	COG0745	RESPONSE REGULATOR receiver
HCX60_RS37530	COG0154	amidase activity
HCX60_RS37535	COG4166	transmembrane transport
HCX60_RS37585	COG3845	ABC transporter
HCX60_RS37620	COG1396	sequence-specific DNA binding
HCX60_RS37620	COG3800	Transcriptional regulator
HCX60_RS37630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCX60_RS37680	COG0640	Transcriptional regulator
HCX60_RS37690	COG0523	cobalamin synthesis protein
HCX60_RS37715	COG0604	alcohol dehydrogenase
HCX60_RS37720	COG2770	Histidine kinase
HCX60_RS37720	COG2208	phosphoserine phosphatase activity
HCX60_RS37765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCX60_RS37770	COG1115	amino acid carrier protein
HCX60_RS37785	COG2770	Histidine kinase
HCX60_RS37785	COG2208	phosphoserine phosphatase activity
HCX60_RS37805	COG1012	belongs to the aldehyde dehydrogenase family
HCX60_RS37820	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCX60_RS37820	COG1902	pentaerythritol trinitrate reductase activity
HCX60_RS37825	COG1960	acyl-CoA dehydrogenase activity
HCX60_RS37830	COG1024	Enoyl-CoA hydratase
HCX60_RS37840	COG0659	secondary active sulfate transmembrane transporter activity
HCX60_RS37845	COG0789	Transcriptional regulator
HCX60_RS37855	COG1063	alcohol dehydrogenase
HCX60_RS37865	COG1309	transcriptional regulator
HCX60_RS37870	COG0300	oxidoreductase activity
HCX60_RS37895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HCX60_RS37970	COG0477	Major facilitator Superfamily
HCX60_RS38000	COG1733	regulation of RNA biosynthetic process
HCX60_RS38085	COG0640	Transcriptional regulator
HCX60_RS38100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS38105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCX60_RS38145	COG1595	DNA-templated transcription, initiation
HCX60_RS38160	COG1733	regulation of RNA biosynthetic process
HCX60_RS38165	COG2226	methyltransferase