locus-tag class description GYK45_RS00005 ENOG41090B9 response to stress GYK45_RS00030 ENOG4105D5G Transposase GYK45_RS00055 ENOG4105DU0 nucleoside hydrolase GYK45_RS00090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GYK45_RS00095 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS00160 ENOG4105C8Y Acetylornithine aminotransferase GYK45_RS00170 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GYK45_RS00180 ENOG4105JSC dimethylmenaquinone methyltransferase GYK45_RS00195 ENOG4105D2T synthase GYK45_RS00205 ENOG4105BZ1 (ABC) transporter GYK45_RS00210 ENOG4105BZ1 (ABC) transporter GYK45_RS00215 ENOG4105BZ1 (ABC) transporter GYK45_RS00275 ENOG4105C5F glutamine synthetase GYK45_RS00280 ENOG4107D0A Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro GYK45_RS00285 ENOG4105CJP fad dependent oxidoreductase GYK45_RS00350 ENOG4105ZX1 Transposase C GYK45_RS00465 ENOG4105C7H Helicase, RecD TraA family GYK45_RS00470 ENOG4105C7H Helicase, RecD TraA family GYK45_RS00475 ENOG4105C7H Helicase, RecD TraA family GYK45_RS00620 ENOG4105IJJ transcriptional regulator, crp fnr family GYK45_RS00735 ENOG4107VHA regulatoR GYK45_RS00745 ENOG4107RN3 metallophosphoesterase GYK45_RS00750 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS00755 ENOG4105BZU Histidine kinase GYK45_RS00760 ENOG4105EYF MMPL domain protein GYK45_RS00765 ENOG4105CHR reductase GYK45_RS00925 ENOG4107SVN transposase GYK45_RS00930 ENOG4105CIR epoxide hydrolase GYK45_RS00980 ENOG4105BZ1 (ABC) transporter GYK45_RS00985 ENOG4105BZ1 (ABC) transporter GYK45_RS00995 ENOG4105C0W non-ribosomal peptide synthetase GYK45_RS01015 ENOG4105BZ1 (ABC) transporter GYK45_RS01050 ENOG4105DZC cytosine deaminase GYK45_RS01060 ENOG4107VFR oxidoreductase GYK45_RS01075 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GYK45_RS01130 ENOG4107T94 Endo-14-beta-xylanase GYK45_RS01195 ENOG4105FDF Could be involved in DNA repair (By similarity) GYK45_RS01210 ENOG4105CXN decarboxylase GYK45_RS01230 ENOG4105CHR reductase GYK45_RS01280 ENOG4105C5Q Transcriptional regulator GYK45_RS01345 ENOG4108UXE Protein tyrosine phosphatase GYK45_RS01350 ENOG4105C3M thioredoxin reductase GYK45_RS01360 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GYK45_RS01375 ENOG4108YYC ycei family GYK45_RS01395 ENOG4105VMP Transcriptional regulator GYK45_RS01435 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein GYK45_RS01440 ENOG4105C01 Dihydroxy-acid dehydratase GYK45_RS01445 ENOG4105D2S major facilitator superfamily GYK45_RS01455 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYK45_RS01460 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYK45_RS01470 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYK45_RS01505 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS01520 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GYK45_RS01530 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS01545 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS01590 ENOG4105K70 DNA-binding protein GYK45_RS01655 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS01660 ENOG4105KBX Transcriptional regulator, TetR family GYK45_RS01675 ENOG4106R7G Glycoside hydrolase family 5 GYK45_RS01690 ENOG4105C2J ABC transporter GYK45_RS01700 ENOG4105EF1 ribulokinase GYK45_RS01710 ENOG4105CKB glycosidase GYK45_RS01715 ENOG4105DRS transport system, permease GYK45_RS01825 ENOG4105DRS transport system, permease GYK45_RS01835 ENOG410836F Transposase GYK45_RS01860 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS01900 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS01920 ENOG4105C2J ABC transporter GYK45_RS01925 ENOG4105CNN ABC, transporter GYK45_RS01955 ENOG4108VCT Sulfite exporter TauE/SafE GYK45_RS01970 ENOG4108IMY Transcriptional regulator GYK45_RS02000 ENOG4105EJ2 Transcriptional regulator GYK45_RS02010 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS02020 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GYK45_RS02030 ENOG4105ERH Fumarylacetoacetate hydrolase GYK45_RS02035 ENOG4108PVQ transcriptional regulator GYK45_RS02080 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS02130 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS02180 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS02190 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS02195 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GYK45_RS02200 ENOG4105DKQ ROK family GYK45_RS02205 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GYK45_RS02230 ENOG4105D2M Aldolase GYK45_RS02280 ENOG4108FN7 Aldo keto reductase GYK45_RS02390 ENOG4105EX0 alpha-galactosidase GYK45_RS02460 ENOG4107S5I aldo keto reductase GYK45_RS02475 ENOG4108W5M transcriptional regulator GYK45_RS02515 ENOG4105BZU Histidine kinase GYK45_RS02535 ENOG4105CS1 NAD(P)H quinone oxidoreductase GYK45_RS02690 ENOG4107S5I aldo keto reductase GYK45_RS02705 ENOG4105CEP NADH dehydrogenase GYK45_RS02720 ENOG4108KPJ rna polymerase sigma factor GYK45_RS02725 ENOG4105CIS alcohol dehydrogenase GYK45_RS02745 ENOG4105C89 phosphohexose isomerase GYK45_RS02750 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GYK45_RS02755 ENOG4105CV1 Transketolase (EC 2.2.1.1) GYK45_RS02780 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS02785 ENOG4105MWK D-amino acid dehydrogenase, small subunit GYK45_RS02795 ENOG4105E5Q amino acid AbC transporter GYK45_RS02825 ENOG4108RCM Nitroreductase GYK45_RS02830 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS02840 ENOG4105MSB protein, conserved in bacteria GYK45_RS02850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYK45_RS02880 ENOG4105KHM amidohydrolase 2 GYK45_RS02885 ENOG4105JSC dimethylmenaquinone methyltransferase GYK45_RS02900 ENOG4108YZG isomerase GYK45_RS02910 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GYK45_RS02930 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYK45_RS02940 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GYK45_RS02960 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS02985 ENOG4105C6F GntR Family Transcriptional Regulator GYK45_RS02995 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase GYK45_RS03010 ENOG4107QM2 Aldo Keto reductase GYK45_RS03030 ENOG4107EFR Flavocytochrome c GYK45_RS03035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GYK45_RS03050 ENOG4105DG4 malate L-lactate dehydrogenase GYK45_RS03060 ENOG4106HB6 Alpha beta hydrolase GYK45_RS03090 ENOG4105DEN Luciferase family GYK45_RS03100 ENOG4105CPU Monooxygenase GYK45_RS03105 ENOG4105CPU Monooxygenase GYK45_RS03135 ENOG4105CHR reductase GYK45_RS03145 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GYK45_RS03160 ENOG4105D7V transposase GYK45_RS03180 ENOG4105EA8 2-Nitropropane dioxygenase GYK45_RS03185 ENOG4105F2C Acetyl-CoA acetyltransferase GYK45_RS03195 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GYK45_RS03205 ENOG4105CC9 acyl-Coa dehydrogenase GYK45_RS03210 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS03215 ENOG4108KEZ Dehydrogenase GYK45_RS03245 ENOG4105CHR reductase GYK45_RS03290 ENOG4105DU1 integral membrane protein, terc GYK45_RS03295 ENOG4105BZ1 (ABC) transporter GYK45_RS03310 ENOG4105CIS alcohol dehydrogenase GYK45_RS03325 ENOG4105F8D glycoside hydrolase family 4 GYK45_RS03335 ENOG4108MGF sugar kinase GYK45_RS03345 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS03355 ENOG4105CNT hydrolase family 2 GYK45_RS03405 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GYK45_RS03420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS03430 ENOG4107YFT Nadph-dependent fmn reductase GYK45_RS03460 ENOG4105I82 acetyl xylan esterase GYK45_RS03485 ENOG4107VFM Dehydrogenase GYK45_RS03545 ENOG4105E93 esterase GYK45_RS03550 ENOG4105BZ1 (ABC) transporter GYK45_RS03560 ENOG4105BZ1 (ABC) transporter GYK45_RS03565 ENOG4108MES Periplasmic binding protein GYK45_RS03570 ENOG4105E0A ABC, transporter GYK45_RS03575 ENOG4105TVJ transport system, permease GYK45_RS03580 ENOG4105DQ5 transport system permease protein GYK45_RS03600 ENOG4105DDV Transcriptional regulator (LacI family GYK45_RS03615 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GYK45_RS03620 ENOG4105F0H myo-inositol catabolism protein GYK45_RS03625 ENOG4105C8M UPF0272 protein GYK45_RS03630 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase GYK45_RS03645 ENOG4105CSH Transporter GYK45_RS03755 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYK45_RS03760 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS03765 ENOG4106M32 3-dehydroquinate synthase GYK45_RS03770 ENOG41061GT Aldolase GYK45_RS03785 ENOG4108KXM LysR family Transcriptional regulator GYK45_RS03795 ENOG4105ETX regulatoR GYK45_RS03810 ENOG4105CHR reductase GYK45_RS03855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS03860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS03875 ENOG4105DKQ ROK family GYK45_RS03880 ENOG4105CBG Sulfatase GYK45_RS03915 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS03920 ENOG4105F38 ABC transporter, permease GYK45_RS03935 ENOG4107TDE lipolytic protein G-D-S-L family GYK45_RS03945 ENOG4105EX0 alpha-galactosidase GYK45_RS03950 ENOG410836F Transposase GYK45_RS03965 ENOG4107RSM transcriptional regulator GYK45_RS03990 ENOG4105C54 Major Facilitator superfamily GYK45_RS04045 ENOG4108P4C Formaldehyde-activating enzyme GYK45_RS04055 ENOG4105C26 Dehydrogenase GYK45_RS04065 ENOG4105C0A alcohol dehydrogenase GYK45_RS04080 ENOG4105EQ0 Major Facilitator superfamily GYK45_RS04095 ENOG4108RNG Permease of the drug metabolite transporter GYK45_RS04120 ENOG4105EKQ RNA-directed DNA polymerase GYK45_RS04130 ENOG4105CGS Alpha-glucosidase GYK45_RS04145 ENOG4105DCG PHP domain protein GYK45_RS04175 ENOG4105DXB Major Facilitator superfamily GYK45_RS04200 ENOG4105CXK mandelate racemase muconate lactonizing GYK45_RS04205 ENOG4105CPC Aldo Keto reductase GYK45_RS04225 ENOG4105CPC Aldo Keto reductase GYK45_RS04265 ENOG4107R0W ABC transporter GYK45_RS04270 ENOG4105EAD ABC transporter GYK45_RS04290 ENOG4105I82 acetyl xylan esterase GYK45_RS04305 ENOG4105D0M Protease HtpX homolog GYK45_RS04335 ENOG4108IG5 Transcriptional regulator GYK45_RS04360 ENOG4108JIK carboxylase GYK45_RS04375 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS04405 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GYK45_RS04410 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GYK45_RS04455 ENOG4105BZ1 (ABC) transporter GYK45_RS04460 ENOG4105BZ1 (ABC) transporter GYK45_RS04475 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GYK45_RS04485 ENOG4105D2S major facilitator superfamily GYK45_RS04490 ENOG4107258 Transcriptional regulator GYK45_RS04555 ENOG4108IG5 Transcriptional regulator GYK45_RS04590 ENOG4105C85 amino acid GYK45_RS04605 ENOG4105CSH Transporter GYK45_RS04640 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GYK45_RS04660 ENOG4105CHR reductase GYK45_RS04670 ENOG4105CHR reductase GYK45_RS04700 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS04710 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS04715 ENOG4105D2S major facilitator superfamily GYK45_RS04730 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) GYK45_RS04735 ENOG4105DUM transcriptional regulator, lysR family GYK45_RS04755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYK45_RS04765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GYK45_RS04775 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS04780 ENOG4108IND Tetr family transcriptional regulator GYK45_RS04785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GYK45_RS04790 ENOG4107T5V SNARE associated Golgi GYK45_RS04800 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS04835 ENOG4105CFC Transporter GYK45_RS04865 ENOG410829K Lysine exporter protein (Lyse ygga) GYK45_RS04880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GYK45_RS04915 ENOG4105DP7 Protocatechuate 4,5-dioxygenase GYK45_RS04935 ENOG4108M9J MaoC like domain protein GYK45_RS04940 ENOG4105CAY ferredoxin--nadp reductase GYK45_RS04955 ENOG4105E2R ROK family GYK45_RS04975 ENOG4108762 serine threonine protein kinase GYK45_RS04995 ENOG4105CAQ asparagine synthetase GYK45_RS05030 ENOG4105EMU Dehydrogenase GYK45_RS05050 ENOG4108KD5 ADP-ribosylation crystallin J1 GYK45_RS05055 ENOG4105FDP GntR family transcriptional regulator GYK45_RS05065 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GYK45_RS05090 ENOG4107Z6X Transcriptional regulator GYK45_RS05095 ENOG4105CHR reductase GYK45_RS05105 ENOG4105C5I Dehydrogenase GYK45_RS05110 ENOG4108J59 Extracellular solute-binding protein, family 5 GYK45_RS05120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS05130 ENOG4108JQ7 (ABC) transporter GYK45_RS05150 ENOG41060NJ transcriptional regulator GYK45_RS05160 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GYK45_RS05180 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GYK45_RS05185 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GYK45_RS05210 ENOG41086D8 Transcriptional regulator GYK45_RS05215 ENOG4105C85 amino acid GYK45_RS05270 ENOG4105KVH Transcriptional regulator GYK45_RS05280 ENOG4105M4P Tetr family transcriptional regulator GYK45_RS05290 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS05295 ENOG4108JA1 polyketide synthase GYK45_RS05380 ENOG4105BZ1 (ABC) transporter GYK45_RS05395 ENOG4105BZ1 (ABC) transporter GYK45_RS05400 ENOG4105BZ1 (ABC) transporter GYK45_RS05415 ENOG4105C29 acyl-CoA thioesterase GYK45_RS05425 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS05470 ENOG4105C0D helicase GYK45_RS05475 ENOG4107XWB Zinc finger, swim domain protein GYK45_RS05480 ENOG4105NBR Pectinesterase GYK45_RS05490 ENOG4105CMG Carbohydrate kinase GYK45_RS05495 ENOG4105DKQ ROK family GYK45_RS05510 ENOG4105ESN nucleotide-binding protein GYK45_RS05515 ENOG4105ESN nucleotide-binding protein GYK45_RS05530 ENOG4105D2B acyl-CoA dehydrogenase GYK45_RS05535 ENOG4105D2B acyl-CoA dehydrogenase GYK45_RS05540 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GYK45_RS05545 ENOG4105D1K glutamate--cysteine ligase GYK45_RS05550 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GYK45_RS05560 ENOG41067HS methyltransferase GYK45_RS05570 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein GYK45_RS05580 ENOG4108NRW Phospholipase, patatin family GYK45_RS05625 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GYK45_RS05630 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS05640 ENOG4105CUB amino acid GYK45_RS05655 ENOG4105K4I Scp-like extracellular GYK45_RS05665 ENOG4108JPW Aminotransferase GYK45_RS05710 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS05765 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GYK45_RS05770 ENOG4105QAX Iron-sulfur GYK45_RS05825 ENOG4105V75 Transcriptional regulator GYK45_RS05940 ENOG4105DEI Mannitol dehydrogenase GYK45_RS05945 ENOG4105DJB Major Facilitator Superfamily GYK45_RS05950 ENOG4105CPQ Dehydrogenase GYK45_RS05955 ENOG4105K5B UPF0225 protein GYK45_RS05970 ENOG4107T6F Xaa-Pro aminopeptidase GYK45_RS05990 ENOG4105C57 major facilitator superfamily GYK45_RS06005 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GYK45_RS06040 ENOG4107QJT sodium dicarboxylate symporter GYK45_RS06045 ENOG4105CMJ mandelate racemase muconate lactonizing GYK45_RS06060 ENOG4107HP6 Transcriptional regulator GYK45_RS06080 ENOG4105CIS alcohol dehydrogenase GYK45_RS06085 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GYK45_RS06110 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GYK45_RS06125 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GYK45_RS06130 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GYK45_RS06135 ENOG4105C7W Xanthine dehydrogenase GYK45_RS06140 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GYK45_RS06160 ENOG4105CND Glycosyl transferase, family 2 GYK45_RS06225 ENOG4108222 arsenate reductase GYK45_RS06305 ENOG4108XEP Alpha Beta Hydrolase Fold protein GYK45_RS06370 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GYK45_RS06380 ENOG4108KPJ rna polymerase sigma factor GYK45_RS06400 ENOG4107RRN ABC transporter substrate-binding protein GYK45_RS06435 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GYK45_RS06440 ENOG4105DD7 kinase (PfkB family GYK45_RS06445 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GYK45_RS06475 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GYK45_RS06480 ENOG4105R1U AraC Family Transcriptional Regulator GYK45_RS06500 ENOG4105DDC Oxidoreductase domain protein GYK45_RS06515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYK45_RS06525 ENOG4105CIK Amidinotransferase GYK45_RS06530 ENOG4105C8Y Acetylornithine aminotransferase GYK45_RS06535 ENOG4108ZFD Antibiotic biosynthesis monooxygenase GYK45_RS06555 ENOG4107SCK Monooxygenase GYK45_RS06565 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS06585 ENOG4105CSH Transporter GYK45_RS06590 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GYK45_RS06605 ENOG4105CFG Acts as a chaperone (By similarity) GYK45_RS06625 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GYK45_RS06635 ENOG4105F7P transcriptional regulator AsnC family GYK45_RS06650 ENOG4105MXW flavin reductase domain protein, FMN-binding GYK45_RS06670 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GYK45_RS06675 ENOG4105C26 Dehydrogenase GYK45_RS06680 ENOG4105DRR Transcriptional regulator, GntR family GYK45_RS06690 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GYK45_RS06705 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS06745 ENOG4105DCG PHP domain protein GYK45_RS06775 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GYK45_RS06790 ENOG4105E2R ROK family GYK45_RS06795 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS06810 ENOG4105EGE secreted protein GYK45_RS06815 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GYK45_RS06820 ENOG4105E98 transcriptional regulator DeoR family GYK45_RS06825 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GYK45_RS06870 ENOG4108PYU two-component system response regulator GYK45_RS06875 ENOG4108FKE two-component system sensor kinase GYK45_RS06880 ENOG4105BZ4 penicillin-binding protein GYK45_RS06890 ENOG4105BZ9 Cytochrome C oxidase, subunit I GYK45_RS06905 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GYK45_RS06945 ENOG4105F2C Acetyl-CoA acetyltransferase GYK45_RS06950 ENOG4108RZE Tetr family transcriptional regulator GYK45_RS06960 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS06970 ENOG4105CSU acyl-Coa dehydrogenase GYK45_RS06975 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS07015 ENOG4105WKW Pfam:DUF1458 GYK45_RS07030 ENOG4108HHA Transketolase GYK45_RS07065 ENOG4105CPC Aldo Keto reductase GYK45_RS07075 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS07080 ENOG4105BZU Histidine kinase GYK45_RS07140 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GYK45_RS07185 ENOG4105PGM cation diffusion facilitator family transporter GYK45_RS07190 ENOG4105CTK cobaltochelatase, cobn subunit GYK45_RS07205 ENOG41081F0 Precorrin-8x methylmutase GYK45_RS07230 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GYK45_RS07235 ENOG4108UW5 maltose o-acetyltransferase GYK45_RS07295 ENOG4105YVM Phosphoesterase, PA-phosphatase related GYK45_RS07310 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GYK45_RS07315 ENOG4105KVH Transcriptional regulator GYK45_RS07320 ENOG4105CSH Transporter GYK45_RS07350 ENOG4105ETX regulatoR GYK45_RS07355 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GYK45_RS07375 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) GYK45_RS07380 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GYK45_RS07410 ENOG4105MWK D-amino acid dehydrogenase, small subunit GYK45_RS07420 ENOG4105C5F glutamine synthetase GYK45_RS07430 ENOG4105EMU Dehydrogenase GYK45_RS07435 ENOG4105CWX Alpha-1,2-mannosidase GYK45_RS07440 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS07445 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) GYK45_RS07450 ENOG4105D4T Citrate transporter GYK45_RS07455 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS07460 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GYK45_RS07465 ENOG4105CI0 Citrate lyase GYK45_RS07485 ENOG4105NAE bifunctional deaminase-reductase domain protein GYK45_RS07490 ENOG4108KPJ rna polymerase sigma factor GYK45_RS07500 ENOG4108V06 Glutathione peroxidase GYK45_RS07590 ENOG4105I1K ABC transporter GYK45_RS07595 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS07605 ENOG4107UEK pfkb domain protein GYK45_RS07615 ENOG4105F8D glycoside hydrolase family 4 GYK45_RS07640 ENOG4105CPQ Dehydrogenase GYK45_RS07665 ENOG4105E98 transcriptional regulator DeoR family GYK45_RS07675 ENOG4105C9U ATP-dependent DNA helicase RecQ GYK45_RS07695 ENOG4106T9R serine protease GYK45_RS07700 ENOG4105C6F GntR Family Transcriptional Regulator GYK45_RS07740 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYK45_RS07770 ENOG4108XNA Gas vesicle GYK45_RS07775 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GYK45_RS07785 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GYK45_RS07805 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GYK45_RS07820 ENOG4105E2A Dehydrogenase GYK45_RS07830 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS07835 ENOG4105QE3 oxidoreductase GYK45_RS07840 ENOG4107QRI Phosphoketolase GYK45_RS07860 ENOG41068KF Universal stress protein GYK45_RS07865 ENOG4105E2A Dehydrogenase GYK45_RS07880 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GYK45_RS07915 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS07935 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GYK45_RS07980 ENOG4105DRS transport system, permease GYK45_RS08060 ENOG41064MX Tetr family transcriptional regulator GYK45_RS08065 ENOG4105CHR reductase GYK45_RS08075 ENOG4105CPC Aldo Keto reductase GYK45_RS08100 ENOG4105DEF Extracellular solute-binding protein, family 5 GYK45_RS08105 ENOG4107S2N Type III effector Hrp-dependent GYK45_RS08115 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GYK45_RS08120 ENOG410804X Transcriptional regulator GYK45_RS08125 ENOG4105BZ1 (ABC) transporter GYK45_RS08130 ENOG4105BZ1 (ABC) transporter GYK45_RS08160 ENOG4105DQE DNA ligase GYK45_RS08165 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS08170 ENOG4107RB3 L-asparaginase GYK45_RS08185 ENOG4108JGH Tetr family transcriptional regulator GYK45_RS08190 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein GYK45_RS08195 ENOG4107S9F NmrA family GYK45_RS08240 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GYK45_RS08255 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GYK45_RS08265 ENOG4105F1K Glutamine amidotransferase GYK45_RS08270 ENOG4105CTQ phosphohexokinase GYK45_RS08335 ENOG4105KI2 Urea amidohydrolase subunit beta GYK45_RS08345 ENOG4105IIU Aminopeptidase GYK45_RS08365 ENOG4105K4H Nlp p60 protein GYK45_RS08390 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GYK45_RS08395 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GYK45_RS08400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GYK45_RS08405 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GYK45_RS08410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GYK45_RS08415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS08420 ENOG4105FBW Monooxygenase GYK45_RS08460 ENOG4108VCA G U mismatch-specific DNA glycosylase GYK45_RS08470 ENOG4105DKQ ROK family GYK45_RS08475 ENOG4105FDP GntR family transcriptional regulator GYK45_RS08480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS08485 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GYK45_RS08530 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GYK45_RS08545 ENOG4105BZU Histidine kinase GYK45_RS08605 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein GYK45_RS08620 ENOG4108Z0R Transferase GYK45_RS08650 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GYK45_RS08660 ENOG4107RGD Major Facilitator superfamily GYK45_RS08665 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GYK45_RS08675 ENOG4107RT4 flavin reductase domain protein GYK45_RS08700 ENOG41068HZ 50S ribosomal protein L32 GYK45_RS08735 ENOG4105SKE transcriptional Regulator LysR family GYK45_RS08775 ENOG4105CHR reductase GYK45_RS08780 ENOG4108IG5 Transcriptional regulator GYK45_RS08800 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS08820 ENOG41080HT Transcriptional regulator, arsr family GYK45_RS08845 ENOG4105D74 hydrolase GYK45_RS08855 ENOG4105C10 Electron transfer flavoprotein GYK45_RS08870 ENOG4105C5X domain protein GYK45_RS08900 ENOG4105F2C Acetyl-CoA acetyltransferase GYK45_RS08905 ENOG4105CGU Enoyl-CoA hydratase GYK45_RS08915 ENOG4105CHR reductase GYK45_RS08945 ENOG41060WC Enoyl-CoA hydratase GYK45_RS08950 ENOG4105D2B acyl-CoA dehydrogenase GYK45_RS08955 ENOG4108KEZ Dehydrogenase GYK45_RS08970 ENOG4105CSH Transporter GYK45_RS08975 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS08990 ENOG4107EFR Flavocytochrome c GYK45_RS08995 ENOG4105CMG Carbohydrate kinase GYK45_RS09015 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GYK45_RS09020 ENOG4108V9W transcriptional regulatory protein GYK45_RS09025 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS09030 ENOG4108YZG isomerase GYK45_RS09095 ENOG4105F8D glycoside hydrolase family 4 GYK45_RS09100 ENOG4105D7K pfkb domain protein GYK45_RS09105 ENOG4105DRS transport system, permease GYK45_RS09130 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS09135 ENOG4105DHQ Histidine kinase GYK45_RS09150 ENOG4107QN1 sodium solute GYK45_RS09245 ENOG4107R13 MMPL domain protein GYK45_RS09260 ENOG4105CPC Aldo Keto reductase GYK45_RS09275 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS09325 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS09340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GYK45_RS09350 ENOG4105CYP glycoside hydrolase, family GYK45_RS09360 ENOG4105C4C beta-galactosidase GYK45_RS09370 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GYK45_RS09375 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS09385 ENOG4105EBR Carboxylesterase GYK45_RS09395 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GYK45_RS09410 ENOG4105CSH Transporter GYK45_RS09420 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GYK45_RS09425 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) GYK45_RS09435 ENOG4108J2P Alpha beta hydrolase fold GYK45_RS09465 ENOG4105TCH Asparagine synthase GYK45_RS09495 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GYK45_RS09520 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS09525 ENOG4107QNK )-transporter GYK45_RS09530 ENOG4105SHT UspA domain-containing protein GYK45_RS09535 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS09540 ENOG41060NJ transcriptional regulator GYK45_RS09560 ENOG4105F5R ABC transporter GYK45_RS09565 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GYK45_RS09570 ENOG4105C2J ABC transporter GYK45_RS09590 ENOG4105DET Rhamnulokinase GYK45_RS09595 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GYK45_RS09620 ENOG4105E2R ROK family GYK45_RS09640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS09670 ENOG4105E2R ROK family GYK45_RS09675 ENOG4105JXB ankyrin repeat-containing protein GYK45_RS09690 ENOG41073TP transcriptional regulator GYK45_RS09695 ENOG4108VW9 Membrane GYK45_RS09700 ENOG4105Q70 GYK45_RS09730 ENOG4105C8S subunit m GYK45_RS09740 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GYK45_RS09755 ENOG4105EW9 transcriptional regulator AsnC family GYK45_RS09775 ENOG4107RR1 TRANSCRIPTIONal GYK45_RS09790 ENOG4108HKT sucrose-6-phosphate hydrolase GYK45_RS09805 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS09820 ENOG4105EG2 ABC transporter, permease GYK45_RS09825 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS09830 ENOG4105XN3 extracellular solute-binding protein family 1 GYK45_RS09845 ENOG4105CPC Aldo Keto reductase GYK45_RS09850 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS09855 ENOG4108J59 Extracellular solute-binding protein, family 5 GYK45_RS09860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS09870 ENOG4105C3U ABC transporter GYK45_RS09875 ENOG4108JQ7 (ABC) transporter GYK45_RS09880 ENOG4108HKT sucrose-6-phosphate hydrolase GYK45_RS09890 ENOG4107R16 Multicopper oxidase GYK45_RS09955 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS09970 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS09975 ENOG4106A3M Cytochrome p-450 GYK45_RS10040 ENOG4105BZU Histidine kinase GYK45_RS10045 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GYK45_RS10080 ENOG4105CHM Aminotransferase GYK45_RS10115 ENOG4105MSB protein, conserved in bacteria GYK45_RS10120 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS10170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYK45_RS10180 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GYK45_RS10185 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GYK45_RS10205 ENOG4105CK5 oxidoreductase GYK45_RS10215 ENOG4105CHR reductase GYK45_RS10270 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GYK45_RS10275 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GYK45_RS10280 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GYK45_RS10285 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GYK45_RS10305 ENOG4105E2R ROK family GYK45_RS10320 ENOG4105C2W permease GYK45_RS10355 ENOG4105CUB amino acid GYK45_RS10375 ENOG4105CXK mandelate racemase muconate lactonizing GYK45_RS10380 ENOG4105DAA L-lactate GYK45_RS10400 ENOG4107258 Transcriptional regulator GYK45_RS10415 ENOG4105DKT Transcriptional regulator GYK45_RS10420 ENOG4105DJV ribulose-phosphate 3-epimerase GYK45_RS10435 ENOG4105BZ1 (ABC) transporter GYK45_RS10440 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GYK45_RS10455 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GYK45_RS10470 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GYK45_RS10480 ENOG4105SKN orotidine 5''-phosphate decarboxylase GYK45_RS10485 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GYK45_RS10490 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GYK45_RS10495 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GYK45_RS10505 ENOG4105CD3 dihydroorotase GYK45_RS10510 ENOG4105CXT aspartate transcarbamylase GYK45_RS10515 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GYK45_RS10525 ENOG410803B Involved in the transcription termination process (By similarity) GYK45_RS10530 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GYK45_RS10535 ENOG4105DC7 peptidase M24 GYK45_RS10545 ENOG4105D49 3-dehydroquinate synthase GYK45_RS10550 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GYK45_RS10555 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GYK45_RS10560 ENOG4107TBS Shikimate dehydrogenase GYK45_RS10570 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GYK45_RS10590 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GYK45_RS10610 ENOG4105CJ1 ABC, transporter GYK45_RS10620 ENOG4105ENE Histidine kinase GYK45_RS10625 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS10630 ENOG4105CUT histidyl-tRNA synthetase GYK45_RS10640 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GYK45_RS10645 ENOG4105C99 atpase involved in dna repair GYK45_RS10650 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GYK45_RS10655 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GYK45_RS10660 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GYK45_RS10665 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GYK45_RS10680 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GYK45_RS10685 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GYK45_RS10690 ENOG4105CDY transcriptional regulatory protein GYK45_RS10700 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GYK45_RS10710 ENOG4105E2K Glycosyl transferase (Group 1 GYK45_RS10715 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GYK45_RS10720 ENOG4108VTU Cdp-alcohol phosphatidyltransferase GYK45_RS10740 ENOG4105C22 threonyL-tRNA synthetase GYK45_RS10755 ENOG4108JDX DNA polymerase iii, epsilon subunit GYK45_RS10775 ENOG4105EKC GYK45_RS10785 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GYK45_RS10790 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS10810 ENOG4105KF0 sporulation and cell division protein, SsgA GYK45_RS10835 ENOG4105F0I Aminotransferase GYK45_RS10885 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GYK45_RS10890 ENOG4107YPT transcriptional regulator GYK45_RS10895 ENOG4105EQ0 Major Facilitator superfamily GYK45_RS10920 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GYK45_RS10925 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GYK45_RS10940 ENOG4105D01 (LipO)protein GYK45_RS10945 ENOG4108UMI ABC transporter, permease GYK45_RS10950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS10985 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS11005 ENOG4105CDH Citrulline--aspartate ligase GYK45_RS11040 ENOG4105CJ2 (LipO)protein GYK45_RS11060 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GYK45_RS11065 ENOG4105C8Y Acetylornithine aminotransferase GYK45_RS11070 ENOG4105CAS nag kinase GYK45_RS11075 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GYK45_RS11080 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GYK45_RS11110 ENOG4105E9K Isocitrate dehydrogenase GYK45_RS11130 ENOG4105T38 integral membrane protein GYK45_RS11140 ENOG4105F32 YngK protein GYK45_RS11165 ENOG4105KT7 mgtC SapB transporter GYK45_RS11175 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GYK45_RS11190 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GYK45_RS11195 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GYK45_RS11200 ENOG4105BZU Histidine kinase GYK45_RS11205 ENOG4108RWN rrna methyltransferase GYK45_RS11210 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GYK45_RS11215 ENOG41084BS 50S ribosomal protein L35 GYK45_RS11220 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GYK45_RS11235 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS11280 ENOG4105C26 Dehydrogenase GYK45_RS11295 ENOG4105CUB amino acid GYK45_RS11300 ENOG4108Z86 Glutamine amidotransferase GYK45_RS11380 ENOG41090WU lipolytic protein G-D-S-L family GYK45_RS11410 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GYK45_RS11425 ENOG4105EWU Squalene--hopene cyclase GYK45_RS11460 ENOG41068W2 Cytochrome p-450 GYK45_RS11465 ENOG4105E1F short-chain dehydrogenase reductase GYK45_RS11490 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GYK45_RS11520 ENOG4105EY8 ABC transporter GYK45_RS11565 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GYK45_RS11575 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS11585 ENOG4105BZM domain protein GYK45_RS11595 ENOG4105C94 Transporter GYK45_RS11620 ENOG4105CNT hydrolase family 2 GYK45_RS11635 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS11640 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS11645 ENOG4105CHU acetyl-coa acetyltransferase GYK45_RS11655 ENOG4105JHE Major Facilitator Superfamily GYK45_RS11660 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYK45_RS11670 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GYK45_RS11720 ENOG4105C26 Dehydrogenase GYK45_RS11725 ENOG4105CUB amino acid GYK45_RS11770 ENOG4108UZX fmn reductase GYK45_RS11780 ENOG4105FBW Monooxygenase GYK45_RS11810 ENOG4105C3U ABC transporter GYK45_RS11815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS11885 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS11920 ENOG4108MP6 LysR family Transcriptional regulator GYK45_RS11930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GYK45_RS11935 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GYK45_RS11940 ENOG4108J5G 6-phosphogluconate dehydrogenase GYK45_RS11950 ENOG4107QN2 dihydrolipoyl dehydrogenase GYK45_RS11960 ENOG4105KVH Transcriptional regulator GYK45_RS11965 ENOG4105ECR NmrA family GYK45_RS11975 ENOG4105DWV Homoserine O-trans-acetylase GYK45_RS11980 ENOG4107S5I aldo keto reductase GYK45_RS11990 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS11995 ENOG4107RSM transcriptional regulator GYK45_RS12000 ENOG4108KTG Membrane protein, drug metabolite transporter GYK45_RS12010 ENOG4105CPN adenine deaminase GYK45_RS12015 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GYK45_RS12025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GYK45_RS12030 ENOG4107TXC Transcriptional regulator GYK45_RS12035 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GYK45_RS12050 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GYK45_RS12055 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GYK45_RS12065 ENOG4107R33 ppx gppa phosphatase GYK45_RS12070 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS12110 ENOG4107QWG 2-Nitropropane dioxygenase GYK45_RS12145 ENOG4105C4R Atp-dependent dna helicase GYK45_RS12155 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 GYK45_RS12200 ENOG4105CVR type I restriction-modification system GYK45_RS12205 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GYK45_RS12210 ENOG4105D9P serine threonine protein kinase GYK45_RS12215 ENOG4105F0K SARP family transcriptional regulator GYK45_RS12255 ENOG4108F3G Type I restriction-modification system, R subunit GYK45_RS12305 ENOG4105UMD exodeoxyribonuclease X GYK45_RS12310 ENOG4107S5I aldo keto reductase GYK45_RS12315 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GYK45_RS12380 ENOG4107T65 Integrase GYK45_RS12405 ENOG4105CMV Succinyl-CoA synthetase subunit beta GYK45_RS12420 ENOG4105CD5 CoA-binding domain protein GYK45_RS12490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GYK45_RS12495 ENOG4105CNN ABC, transporter GYK45_RS12500 ENOG4105C2J ABC transporter GYK45_RS12505 ENOG4105DKQ ROK family GYK45_RS12525 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GYK45_RS12535 ENOG4107QHI -hydrogenase GYK45_RS12540 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GYK45_RS12545 ENOG4108IND Tetr family transcriptional regulator GYK45_RS12555 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS12580 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GYK45_RS12585 ENOG4105DHU Bile acid GYK45_RS12610 ENOG4105CV8 reductase GYK45_RS12620 ENOG4105K6V RNA polymerase GYK45_RS12625 ENOG4105RNG membrane GYK45_RS12630 ENOG4105CVP deoxyribo-dipyrimidine photolyase GYK45_RS12635 ENOG410842T Pterin carbinolamine dehydratase GYK45_RS12650 ENOG4105CSH Transporter GYK45_RS12665 ENOG4105DHU Bile acid GYK45_RS12675 ENOG4105D5Q Arginine ornithine antiporter GYK45_RS12685 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GYK45_RS12690 ENOG4108VEN abc transporter atp-binding protein GYK45_RS12705 ENOG4105C2J ABC transporter GYK45_RS12710 ENOG4105DFW ABC transporter GYK45_RS12720 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GYK45_RS12745 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GYK45_RS12755 ENOG4108IGT Dipeptidase GYK45_RS12770 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein GYK45_RS12805 ENOG41079R3 acyl carrier protein GYK45_RS12810 ENOG4108Y5I Cyclase dehydrase GYK45_RS12815 ENOG4105KTE polyketide synthesis cyclase GYK45_RS12875 ENOG4108Z0Z intracellular protease Pfpi family GYK45_RS12880 ENOG4105CH6 catalase GYK45_RS12905 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GYK45_RS12910 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GYK45_RS12945 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GYK45_RS12950 ENOG4108ME1 Peptidase M55 D-aminopeptidase GYK45_RS12995 ENOG4105CGS Alpha-glucosidase GYK45_RS13010 ENOG4105RFZ Methylmalonyl-coA mutase GYK45_RS13015 ENOG4105CI0 Citrate lyase GYK45_RS13025 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS13030 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GYK45_RS13040 ENOG4105BZW Glycerate kinase GYK45_RS13065 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GYK45_RS13100 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GYK45_RS13110 ENOG4105ECY inositol monophosphatase GYK45_RS13135 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GYK45_RS13140 ENOG4105C8Y Acetylornithine aminotransferase GYK45_RS13160 ENOG41080V3 Major Facilitator superfamily GYK45_RS13170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GYK45_RS13205 ENOG4105DRP amino acid AbC transporter GYK45_RS13210 ENOG4105EAD ABC transporter GYK45_RS13215 ENOG4107UBR Extracellular solute-binding protein family 3 GYK45_RS13220 ENOG4105CDA abc transporter atp-binding protein GYK45_RS13245 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GYK45_RS13255 ENOG4105DKQ ROK family GYK45_RS13260 ENOG4105C2J ABC transporter GYK45_RS13265 ENOG41062B0 ABC transporter, permease GYK45_RS13275 ENOG4105FDP GntR family transcriptional regulator GYK45_RS13290 ENOG4105F87 Dehydratase GYK45_RS13295 ENOG4108RTU Aldolase GYK45_RS13370 ENOG4105DHG Allantoate amidinohydrolase GYK45_RS13380 ENOG4107HP6 Transcriptional regulator GYK45_RS13390 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GYK45_RS13395 ENOG4107R9S Malate synthase GYK45_RS13405 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GYK45_RS13415 ENOG4105VT2 5-hydroxyisourate hydrolase GYK45_RS13450 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS13460 ENOG4107QUT magnesium and cobalt transport protein CorA GYK45_RS13470 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GYK45_RS13485 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GYK45_RS13510 ENOG4105DRR Transcriptional regulator, GntR family GYK45_RS13560 ENOG4105C7K acetolactate synthase GYK45_RS13580 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GYK45_RS13605 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GYK45_RS13615 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GYK45_RS13620 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) GYK45_RS13635 ENOG4107UWC ABC, transporter GYK45_RS13640 ENOG4108IY8 ABC, transporter GYK45_RS13645 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GYK45_RS13655 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GYK45_RS13660 ENOG4108KB2 LysR family Transcriptional regulator GYK45_RS13665 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GYK45_RS13700 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYK45_RS13705 ENOG4107WA4 MmpL domain-containing protein GYK45_RS13750 ENOG4105FDP GntR family transcriptional regulator GYK45_RS13755 ENOG4105DKW ABC transporter GYK45_RS13800 ENOG4105E0X reductase GYK45_RS13855 ENOG4105BZU Histidine kinase GYK45_RS13860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS13905 ENOG4105BZ4 penicillin-binding protein GYK45_RS13910 ENOG4105E18 UPF0276 protein GYK45_RS13930 ENOG4107JTW chlorite dismutase GYK45_RS13935 ENOG4105C1Q protoporphyrinogen oxidase GYK45_RS13940 ENOG4107HP6 Transcriptional regulator GYK45_RS13955 ENOG4105DJB Major Facilitator Superfamily GYK45_RS13960 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GYK45_RS13970 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GYK45_RS13985 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GYK45_RS13995 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS14010 ENOG4105CUB amino acid GYK45_RS14015 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GYK45_RS14020 ENOG4107RNG ABC transporter GYK45_RS14025 ENOG4105C2J ABC transporter GYK45_RS14030 ENOG4105DFW ABC transporter GYK45_RS14035 ENOG4105E2R ROK family GYK45_RS14045 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS14065 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GYK45_RS14070 ENOG4105KVH Transcriptional regulator GYK45_RS14095 ENOG4107QM5 aconitate hydratase GYK45_RS14105 ENOG4105EQ2 LysR family Transcriptional regulator GYK45_RS14115 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GYK45_RS14120 ENOG4105RQF LysR family Transcriptional regulator GYK45_RS14125 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GYK45_RS14170 ENOG4105EX0 alpha-galactosidase GYK45_RS14180 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS14185 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GYK45_RS14185 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GYK45_RS14200 ENOG4105JXH GntR family transcriptional regulator GYK45_RS14205 ENOG4105CXK mandelate racemase muconate lactonizing GYK45_RS14215 ENOG4108UHU Aldolase GYK45_RS14220 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GYK45_RS14240 ENOG4105DBV ornithine carbamoyltransferase GYK45_RS14245 ENOG4105CEU Arginine dihydrolase GYK45_RS14270 ENOG4107S1Q Phosphatase GYK45_RS14310 ENOG4105EYF MMPL domain protein GYK45_RS14335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GYK45_RS14340 ENOG4105C0X amino acid GYK45_RS14375 ENOG4107VEG TrkA-N domain protein GYK45_RS14440 ENOG4106F60 Histidine kinase GYK45_RS14445 ENOG4105F44 Two component transcriptional regulator, winged helix family GYK45_RS14455 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GYK45_RS14480 ENOG4105KHC sulfurtransferase GYK45_RS14490 ENOG4107W53 thymidine kinase GYK45_RS14505 ENOG4105CD5 CoA-binding domain protein GYK45_RS14510 ENOG410849S phosphocarrier protein (HPr) GYK45_RS14515 ENOG4105DRR Transcriptional regulator, GntR family GYK45_RS14550 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GYK45_RS14560 ENOG4107QN1 sodium solute GYK45_RS14580 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GYK45_RS14585 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS14590 ENOG4105DRR Transcriptional regulator, GntR family GYK45_RS14610 ENOG4105C9U ATP-dependent DNA helicase RecQ GYK45_RS14625 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GYK45_RS14655 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GYK45_RS14660 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GYK45_RS14665 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GYK45_RS14695 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GYK45_RS14705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GYK45_RS14710 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GYK45_RS14720 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GYK45_RS14735 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GYK45_RS14740 ENOG4107HP6 Transcriptional regulator GYK45_RS14765 ENOG4105CDA abc transporter atp-binding protein GYK45_RS14770 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GYK45_RS14775 ENOG4105EAD ABC transporter GYK45_RS14780 ENOG4105DRP amino acid AbC transporter GYK45_RS14795 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GYK45_RS14845 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GYK45_RS14860 ENOG4105WBV Transcriptional regulator GYK45_RS14865 ENOG4105CEV competence damage-inducible protein GYK45_RS14875 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GYK45_RS14885 ENOG4107QZI cell division protein FtsK GYK45_RS14925 ENOG4105CN5 Metallo-Beta-Lactamase GYK45_RS14930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYK45_RS14955 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GYK45_RS14960 ENOG4105C1V Peptidase, M16 GYK45_RS14965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GYK45_RS14970 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GYK45_RS15110 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GYK45_RS15115 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GYK45_RS15125 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GYK45_RS15140 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GYK45_RS15160 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GYK45_RS15175 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GYK45_RS15180 ENOG4105DZP Membrane-associated zinc metalloprotease GYK45_RS15185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GYK45_RS15210 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GYK45_RS15235 ENOG4105G9B Transcriptional regulator GYK45_RS15255 ENOG4105CJP fad dependent oxidoreductase GYK45_RS15260 ENOG4105D38 putrescine abc transporter GYK45_RS15265 ENOG4105F38 ABC transporter, permease GYK45_RS15270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS15295 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GYK45_RS15310 ENOG4105C26 Dehydrogenase GYK45_RS15335 ENOG4105C7K acetolactate synthase GYK45_RS15340 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GYK45_RS15355 ENOG4108UCS ABC, transporter GYK45_RS15370 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GYK45_RS15375 ENOG4105KNE Phosphatidate cytidylyltransferase GYK45_RS15380 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GYK45_RS15385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GYK45_RS15390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GYK45_RS15395 ENOG4105CE9 30S ribosomal protein S2 GYK45_RS15410 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS15450 ENOG41080R2 UPF0102 protein GYK45_RS15460 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GYK45_RS15465 ENOG4107QYR Signal peptidase i GYK45_RS15470 ENOG4107QYR Signal peptidase i GYK45_RS15480 ENOG4107QYR Signal peptidase i GYK45_RS15485 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GYK45_RS15490 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GYK45_RS15500 ENOG41082KU UPF0109 protein GYK45_RS15505 ENOG4105K5M 30s ribosomal protein S16 GYK45_RS15515 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GYK45_RS15600 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GYK45_RS15610 ENOG4105KVH Transcriptional regulator GYK45_RS15615 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GYK45_RS15620 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GYK45_RS15625 ENOG41084BZ 50S ribosomal protein L32 GYK45_RS15640 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GYK45_RS15645 ENOG4106H78 methyltransferase GYK45_RS15655 ENOG4105DP4 dak2 domain fusion protein ylov GYK45_RS15660 ENOG4105VB9 50S ribosomal protein l28 GYK45_RS15665 ENOG4105DWF phosphomethylpyrimidine kinase GYK45_RS15690 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GYK45_RS15700 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) GYK45_RS15705 ENOG4105K70 DNA-binding protein GYK45_RS15715 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYK45_RS15725 ENOG41069M3 Transcriptional regulator GYK45_RS15765 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GYK45_RS15770 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GYK45_RS15785 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS15805 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS15825 ENOG4105D8K carboxyl transferase GYK45_RS15830 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GYK45_RS15835 ENOG4105CM2 brancheD-chain amino acid aminotransferase GYK45_RS15840 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GYK45_RS15850 ENOG4105C26 Dehydrogenase GYK45_RS15870 ENOG4105C57 major facilitator superfamily GYK45_RS15905 ENOG4108JQ1 Dehydrogenase GYK45_RS15910 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GYK45_RS15915 ENOG4108ZP8 Acetolactate synthase small subunit GYK45_RS15925 ENOG4105BZU Histidine kinase GYK45_RS15935 ENOG4105CPC Aldo Keto reductase GYK45_RS15945 ENOG4107SM8 Adenylate Guanylate cyclase GYK45_RS15955 ENOG4105EYF MMPL domain protein GYK45_RS15975 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS15980 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS15990 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GYK45_RS16000 ENOG4105E0T Short-chain dehydrogenase reductase Sdr GYK45_RS16025 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GYK45_RS16050 ENOG4105EBM Alpha Beta Hydrolase Fold protein GYK45_RS16065 ENOG4105EN6 Membrane GYK45_RS16070 ENOG4108JQ7 (ABC) transporter GYK45_RS16085 ENOG4108J59 Extracellular solute-binding protein, family 5 GYK45_RS16115 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GYK45_RS16120 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GYK45_RS16125 ENOG4105EJQ L-serine dehydratase GYK45_RS16140 ENOG4105CVR type I restriction-modification system GYK45_RS16170 ENOG4105DZR Type I site-specific deoxyribonuclease GYK45_RS16190 ENOG4105T1M mycothiol conjugate amidase mca GYK45_RS16270 ENOG4105BZ1 (ABC) transporter GYK45_RS16275 ENOG4105BZ1 (ABC) transporter GYK45_RS16315 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) GYK45_RS16340 ENOG4105CVA phosphate GYK45_RS16355 ENOG4105CX8 fg-gap repeat protein GYK45_RS16370 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYK45_RS16375 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GYK45_RS16385 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GYK45_RS16390 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GYK45_RS16415 ENOG4108MRH transcriptional regulatory protein GYK45_RS16425 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GYK45_RS16430 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS16435 ENOG4106UDK Cellulose-binding, family II GYK45_RS16485 ENOG4108JGH Tetr family transcriptional regulator GYK45_RS16505 ENOG4107QJZ Glycosyl transferase, family 2 GYK45_RS16510 ENOG4108KGH TRANSCRIPTIONal GYK45_RS16515 ENOG4105EG2 ABC transporter, permease GYK45_RS16545 ENOG4105CTQ phosphohexokinase GYK45_RS16550 ENOG4105C6K Malic enzyme GYK45_RS16555 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GYK45_RS16595 ENOG4105WX6 Membrane GYK45_RS16650 ENOG4105ETX regulatoR GYK45_RS16715 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GYK45_RS16730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS16735 ENOG410630P Transcriptional regulator GYK45_RS16755 ENOG4105IIP Membrane GYK45_RS16760 ENOG4108XG2 Histidine kinase GYK45_RS16765 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS16775 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GYK45_RS16780 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GYK45_RS16785 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GYK45_RS16790 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GYK45_RS16795 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GYK45_RS16800 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GYK45_RS16805 ENOG4105ZA1 atp synthase GYK45_RS16815 ENOG4105Z3P ATP synthase GYK45_RS16825 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GYK45_RS16830 ENOG4107ZF2 Phosphatase GYK45_RS16840 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GYK45_RS16845 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GYK45_RS16850 ENOG4105VFB Binds the 23S rRNA (By similarity) GYK45_RS16855 ENOG4108KGH TRANSCRIPTIONal GYK45_RS16870 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GYK45_RS16875 ENOG4105D6E homoserine dehydrogenase GYK45_RS16880 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GYK45_RS16885 ENOG4105C75 arginyL-tRNA synthetase GYK45_RS16885 ENOG4105C75 arginyL-tRNA synthetase GYK45_RS16980 ENOG4107RTG Major Facilitator superfamily GYK45_RS16985 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS16990 ENOG4105XYF acetyltransferase GYK45_RS17020 ENOG4105K4H Nlp p60 protein GYK45_RS17070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GYK45_RS17075 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GYK45_RS17090 ENOG4108PYU two-component system response regulator GYK45_RS17095 ENOG4105EB3 Histidine kinase GYK45_RS17100 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GYK45_RS17110 ENOG4108Z6Z Transcriptional regulator GYK45_RS17135 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GYK45_RS17150 ENOG4105C0W non-ribosomal peptide synthetase GYK45_RS17175 ENOG4105C6K Malic enzyme GYK45_RS17185 ENOG4108HW4 amino acid AbC transporter GYK45_RS17210 ENOG4108VEQ Superoxide dismutase GYK45_RS17235 ENOG4108KXM LysR family Transcriptional regulator GYK45_RS17265 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GYK45_RS17285 ENOG4105CSV Glutaminase GYK45_RS17325 ENOG4105CBD Diacylglycerol kinase GYK45_RS17340 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GYK45_RS17345 ENOG4105D17 glycoside hydrolase, family 3 domain protein GYK45_RS17355 ENOG4105D56 permease protein GYK45_RS17405 ENOG4107SCK Monooxygenase GYK45_RS17410 ENOG4105EMU Dehydrogenase GYK45_RS17435 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GYK45_RS17440 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GYK45_RS17460 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GYK45_RS17465 ENOG4105WMN AntiSigma factor GYK45_RS17470 ENOG4105EMN RNA polymerase sigma factor GYK45_RS17480 ENOG4108RAV Conserved protein GYK45_RS17490 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GYK45_RS17495 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GYK45_RS17500 ENOG4105KPY Small multidrug resistance protein GYK45_RS17510 ENOG4107TK4 histidinol-phosphate phosphatase GYK45_RS17545 ENOG4105DJZ UPF0182 protein GYK45_RS17555 ENOG41063PX domain protein GYK45_RS17615 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GYK45_RS17640 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GYK45_RS17645 ENOG4105C4R Atp-dependent dna helicase GYK45_RS17740 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GYK45_RS17750 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GYK45_RS17770 ENOG4105D7N magnesium and cobalt transport protein CorA GYK45_RS17810 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GYK45_RS17825 ENOG4105DU6 RNA polymerase GYK45_RS17840 ENOG4105CGU Enoyl-CoA hydratase GYK45_RS17845 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GYK45_RS17855 ENOG4105EEI dihydropteroate synthase GYK45_RS17860 ENOG4108URH decarboxylase GYK45_RS17865 ENOG4107R4C succinyl-diaminopimelate desuccinylase GYK45_RS17885 ENOG4108Z4U Ferredoxin GYK45_RS17900 ENOG4108S01 response regulator GYK45_RS17905 ENOG4105BZU Histidine kinase GYK45_RS17915 ENOG4108M15 ABC transporter GYK45_RS17935 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GYK45_RS17955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS17960 ENOG4105DEF Extracellular solute-binding protein, family 5 GYK45_RS17970 ENOG4105C3U ABC transporter GYK45_RS17975 ENOG4108JQ7 (ABC) transporter GYK45_RS17990 ENOG4108JQ7 (ABC) transporter GYK45_RS18000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS18005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS18010 ENOG4108J59 Extracellular solute-binding protein, family 5 GYK45_RS18040 ENOG4108JQ7 (ABC) transporter GYK45_RS18050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS18055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS18060 ENOG4105DEF Extracellular solute-binding protein, family 5 GYK45_RS18065 ENOG4105CI3 gtp-binding protein typa GYK45_RS18085 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GYK45_RS18110 ENOG4107QTZ amino acid GYK45_RS18130 ENOG4105KRQ Addiction module toxin, Txe YoeB family GYK45_RS18135 ENOG41084HI prevent-host-death family GYK45_RS18140 ENOG4107RSM transcriptional regulator GYK45_RS18150 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS18155 ENOG4105D2S major facilitator superfamily GYK45_RS18175 ENOG4105EMU Dehydrogenase GYK45_RS18220 ENOG4105C3G gtp-binding protein GYK45_RS18235 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GYK45_RS18240 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GYK45_RS18265 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GYK45_RS18275 ENOG4107GFK fumarate GYK45_RS18280 ENOG4106UDK Cellulose-binding, family II GYK45_RS18295 ENOG4105C9Q fumarate hydratase class II GYK45_RS18315 ENOG4108W9H Tetr family transcriptional regulator GYK45_RS18320 ENOG4107S9B Shikimate dehydrogenase GYK45_RS18335 ENOG4105ESF Peptidoglycan binding domain protein GYK45_RS18365 ENOG4105BZ4 penicillin-binding protein GYK45_RS18385 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GYK45_RS18400 ENOG4105D3R alkyl hydroperoxide reductase GYK45_RS18405 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS18420 ENOG4108IAB Phoh family GYK45_RS18425 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GYK45_RS18440 ENOG4105VEQ Cold shock protein GYK45_RS18445 ENOG4107R5R arsenical pump membrane protein GYK45_RS18450 ENOG4107QKZ Ompa motb domain protein GYK45_RS18550 ENOG4105C6Z Gluconate GYK45_RS18560 ENOG4108FUF Transcriptional regulator, IclR family GYK45_RS18600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS18605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS18640 ENOG4108UT2 hemolysin iii GYK45_RS18650 ENOG4105C7Z Conserved Protein GYK45_RS18670 ENOG4108W5M transcriptional regulator GYK45_RS18695 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GYK45_RS18740 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GYK45_RS18790 ENOG4107X2D transcriptional regulator, merr family GYK45_RS18820 ENOG4105MUA Resistance protein GYK45_RS18850 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GYK45_RS18860 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS18885 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS18930 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS18950 ENOG4107RSM transcriptional regulator GYK45_RS18955 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GYK45_RS18970 ENOG4108KB2 LysR family Transcriptional regulator GYK45_RS18985 ENOG4107QSI ABC, transporter GYK45_RS18995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS19010 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GYK45_RS19105 ENOG4105CPC Aldo Keto reductase GYK45_RS19115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS19155 ENOG4105BZU Histidine kinase GYK45_RS19170 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GYK45_RS19175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GYK45_RS19180 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GYK45_RS19185 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GYK45_RS19195 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GYK45_RS19205 ENOG4108RZE Tetr family transcriptional regulator GYK45_RS19225 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GYK45_RS19235 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS19240 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GYK45_RS19275 ENOG4105C5H ABC transporter GYK45_RS19280 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GYK45_RS19285 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GYK45_RS19290 ENOG41069ER domain protein GYK45_RS19295 ENOG4105F8V Hydrolase, tatD family GYK45_RS19320 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GYK45_RS19385 ENOG4108JJB ABC transporter GYK45_RS19395 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GYK45_RS19400 ENOG4105EYF MMPL domain protein GYK45_RS19425 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GYK45_RS19430 ENOG4105F95 Monooxygenase GYK45_RS19440 ENOG4105CGK Exodeoxyribonuclease III GYK45_RS19455 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GYK45_RS19470 ENOG41082YX Transcriptional regulator, arsr family GYK45_RS19480 ENOG4108Z7F N-acetyltransferase GYK45_RS19515 ENOG4105D9U N-acetyltransferase GYK45_RS19525 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GYK45_RS19535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GYK45_RS19540 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GYK45_RS19550 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GYK45_RS19560 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GYK45_RS19570 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GYK45_RS19580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS19590 ENOG4108JU3 Alkyl hydroperoxide reductase GYK45_RS19595 ENOG4105DM4 PTS System GYK45_RS19600 ENOG4105DE4 1-phosphofructokinase GYK45_RS19605 ENOG410804X Transcriptional regulator GYK45_RS19610 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GYK45_RS19630 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GYK45_RS19655 ENOG4105EJ2 Transcriptional regulator GYK45_RS19695 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GYK45_RS19705 ENOG4105DUU IucA IucC family protein GYK45_RS19740 ENOG4105CMR udp-glucose 4-epimerase GYK45_RS19765 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GYK45_RS19770 ENOG410630P Transcriptional regulator GYK45_RS19810 ENOG4108UGD Serine Threonine protein kinase GYK45_RS19820 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme GYK45_RS19825 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GYK45_RS19845 ENOG4105MHT Transcriptional regulator, ARSR family GYK45_RS19850 ENOG4105K6H D-cysteine desulfhydrase GYK45_RS19865 ENOG4105FDF Could be involved in DNA repair (By similarity) GYK45_RS19875 ENOG4108R86 Transcriptional regulator GYK45_RS19925 ENOG4105EPJ extracellular solute-binding protein family 1 GYK45_RS19935 ENOG4105DZ1 carboxypeptidase GYK45_RS19960 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS19980 ENOG41065RQ ADP-ribosylation crystallin J1 GYK45_RS19990 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GYK45_RS20010 ENOG4105CHR reductase GYK45_RS20045 ENOG4105F0K SARP family transcriptional regulator GYK45_RS20050 ENOG4105F0K SARP family transcriptional regulator GYK45_RS20060 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS20090 ENOG4108762 serine threonine protein kinase GYK45_RS20100 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GYK45_RS20110 ENOG4105D2B acyl-CoA dehydrogenase GYK45_RS20145 ENOG4105CGU Enoyl-CoA hydratase GYK45_RS20150 ENOG4105MXW flavin reductase domain protein, FMN-binding GYK45_RS20160 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS20165 ENOG4107QPD alcohol dehydrogenase GYK45_RS20200 ENOG4105D2B acyl-CoA dehydrogenase GYK45_RS20205 ENOG4105CC9 acyl-Coa dehydrogenase GYK45_RS20210 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS20230 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GYK45_RS20235 ENOG4107QQG Dehydrogenase GYK45_RS20245 ENOG4105DFF Rod shape-determining protein mreb GYK45_RS20260 ENOG4107QVP Dehydrogenase GYK45_RS20270 ENOG4108MMM RNA Polymerase GYK45_RS20275 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS20280 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GYK45_RS20285 ENOG4105DND Transcriptional regulator GYK45_RS20295 ENOG4105EMU Dehydrogenase GYK45_RS20300 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GYK45_RS20305 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GYK45_RS20360 ENOG4106F60 Histidine kinase GYK45_RS20365 ENOG4105F44 Two component transcriptional regulator, winged helix family GYK45_RS20380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS20385 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS20390 ENOG4105EBM Alpha Beta Hydrolase Fold protein GYK45_RS20405 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GYK45_RS20430 ENOG4108097 ATP-binding protein GYK45_RS20435 ENOG4105DWV Homoserine O-trans-acetylase GYK45_RS20440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GYK45_RS20470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GYK45_RS20480 ENOG4105CS9 pantothenic acid kinase GYK45_RS20490 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GYK45_RS20500 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GYK45_RS20515 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GYK45_RS20535 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GYK45_RS20540 ENOG4105FUA antagonist GYK45_RS20545 ENOG4107MMM Anti-sigma-factor antagonist GYK45_RS20550 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GYK45_RS20555 ENOG4108ZT0 50S ribosomal protein l17 GYK45_RS20560 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GYK45_RS20570 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GYK45_RS20575 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GYK45_RS20585 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GYK45_RS20605 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GYK45_RS20615 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GYK45_RS20620 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GYK45_RS20630 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GYK45_RS20640 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GYK45_RS20645 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GYK45_RS20650 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GYK45_RS20655 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GYK45_RS20660 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GYK45_RS20665 ENOG41082SA 50s ribosomal protein l29 GYK45_RS20670 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GYK45_RS20675 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GYK45_RS20680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GYK45_RS20685 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GYK45_RS20690 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GYK45_RS20695 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GYK45_RS20700 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GYK45_RS20705 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GYK45_RS20710 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GYK45_RS20735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GYK45_RS20740 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GYK45_RS20750 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GYK45_RS20775 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GYK45_RS20785 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GYK45_RS20790 ENOG4108VZM 50s ribosomal protein L10 GYK45_RS20800 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GYK45_RS20805 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GYK45_RS20810 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GYK45_RS20835 ENOG4107R4N Cell wall formation (By similarity) GYK45_RS20845 ENOG410900P UPF0336 protein GYK45_RS20850 ENOG4105WDJ 50S ribosomal protein L33 GYK45_RS20890 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GYK45_RS20905 ENOG4108VPT UPF0234 protein GYK45_RS20915 ENOG4105D0M Protease HtpX homolog GYK45_RS20940 ENOG4107YX3 NADH dehydrogenase subunit j GYK45_RS20945 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS20950 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GYK45_RS20955 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GYK45_RS20965 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GYK45_RS20985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GYK45_RS20990 ENOG4105DQU oxidoreductase, subunit beta GYK45_RS20995 ENOG4105C0X amino acid GYK45_RS21000 ENOG4105ECR NmrA family GYK45_RS21060 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS21070 ENOG4105D65 subunit l GYK45_RS21075 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS21090 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GYK45_RS21100 ENOG4107QIZ NADH dehydrogenase GYK45_RS21115 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GYK45_RS21120 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS21150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GYK45_RS21160 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GYK45_RS21175 ENOG4105EV6 Pfam:DUF178 GYK45_RS21180 ENOG4105VEQ Cold shock protein GYK45_RS21200 ENOG4108R86 Transcriptional regulator GYK45_RS21210 ENOG4105KPY Small multidrug resistance protein GYK45_RS21215 ENOG4105CK2 sodium dicarboxylate symporter GYK45_RS21230 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GYK45_RS21235 ENOG4105DVY radical SAM domain protein GYK45_RS21245 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GYK45_RS21250 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GYK45_RS21255 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GYK45_RS21265 ENOG4105CRE cytochrome C GYK45_RS21270 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GYK45_RS21275 ENOG4107QIV Cytochrome c biogenesis protein GYK45_RS21290 ENOG4108RH7 phosphoglycerate mutase GYK45_RS21295 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GYK45_RS21310 ENOG4105KK4 UPF0060 membrane protein GYK45_RS21340 ENOG4105E0Y RtcB Protein GYK45_RS21360 ENOG4105DK7 lysyl-tRNA synthetase GYK45_RS21365 ENOG4105C75 arginyL-tRNA synthetase GYK45_RS21385 ENOG4107Z1W Fructose transport system kinase GYK45_RS21390 ENOG4105D52 delta-aminolevulinic acid dehydratase GYK45_RS21395 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GYK45_RS21400 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GYK45_RS21405 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GYK45_RS21410 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GYK45_RS21420 ENOG4108RXW HAD-superfamily subfamily IB hydrolase GYK45_RS21455 ENOG4108XFF GYK45_RS21470 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GYK45_RS21490 ENOG4105C31 Tryptophanyl-tRNA synthetase GYK45_RS21495 ENOG4105II7 pyrroline-5-carboxylate reductase GYK45_RS21525 ENOG4105C01 Dihydroxy-acid dehydratase GYK45_RS21530 ENOG4105U5Y Transcriptional regulator GYK45_RS21535 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GYK45_RS21540 ENOG4107R33 ppx gppa phosphatase GYK45_RS21545 ENOG4108JWX GYK45_RS21560 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GYK45_RS21580 ENOG4105NTW Transcriptional regulator GYK45_RS21600 ENOG4105CEN a g-specific adenine glycosylase GYK45_RS21605 ENOG4105NAF rna polymerase sigma factor GYK45_RS21610 ENOG41075QH Lipoprotein CseA GYK45_RS21615 ENOG4108PYU two-component system response regulator GYK45_RS21620 ENOG4108FKE two-component system sensor kinase GYK45_RS21625 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GYK45_RS21630 ENOG4105HFT AraC family transcriptional regulator GYK45_RS21640 ENOG4108IG5 Transcriptional regulator GYK45_RS21645 ENOG4105DR5 peptidase GYK45_RS21670 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GYK45_RS21680 ENOG4105VFU Rna-binding protein GYK45_RS21690 ENOG4106F60 Histidine kinase GYK45_RS21695 ENOG4105F44 Two component transcriptional regulator, winged helix family GYK45_RS21710 ENOG4105C19 ABC transporter GYK45_RS21730 ENOG4105ETX regulatoR GYK45_RS21740 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS21745 ENOG4107NHD transcriptional regulator GYK45_RS21780 ENOG4105KHC sulfurtransferase GYK45_RS21785 ENOG4105PKJ carbohydrate binding GYK45_RS21800 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GYK45_RS21805 ENOG41090R7 Ferric uptake GYK45_RS21810 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GYK45_RS21815 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GYK45_RS21830 ENOG4108Z4X TRANSCRIPTIONal GYK45_RS21855 ENOG4108X0B nad(p)h dehydrogenase (quinone) GYK45_RS21870 ENOG4105CHP RNA polymerase GYK45_RS21900 ENOG4108UVJ appr-1-p processing domain protein GYK45_RS21925 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS21930 ENOG4105CJ3 phosphate transporter GYK45_RS21940 ENOG4105VPX protein, conserved in bacteria GYK45_RS21955 ENOG4105DNP FAD linked oxidase domain protein GYK45_RS21960 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GYK45_RS21965 ENOG4105E4C Lytic transglycosylase catalytic GYK45_RS22060 ENOG4105D5U fad dependent oxidoreductase GYK45_RS22065 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GYK45_RS22075 ENOG4105EMN RNA polymerase sigma factor GYK45_RS22090 ENOG4105S7A ErfK ybiS ycfS ynhG family protein GYK45_RS22115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS22145 ENOG4107SET aldo keto reductase GYK45_RS22190 ENOG4105C1J atp-dependent rna helicase GYK45_RS22230 ENOG4108KU3 Integrase GYK45_RS22280 ENOG4105FDP GntR family transcriptional regulator GYK45_RS22310 ENOG4105CSH Transporter GYK45_RS22325 ENOG4105CQ7 ATP-dependent helicase GYK45_RS22345 ENOG4108TAC GYK45_RS22360 ENOG4105CXB phosphoribosylaminoimidazole synthetase GYK45_RS22380 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GYK45_RS22385 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GYK45_RS22390 ENOG410839H phosphoribosylformylglycinamidine synthase GYK45_RS22420 ENOG4105C8V SAICAR synthetase GYK45_RS22445 ENOG4105C12 Phosphoribosylglycinamide synthetase GYK45_RS22460 ENOG4108WYP Transcriptional regulator GYK45_RS22465 ENOG4108JPW Aminotransferase GYK45_RS22480 ENOG4108762 serine threonine protein kinase GYK45_RS22485 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GYK45_RS22500 ENOG4105CIG ABC transporter GYK45_RS22505 ENOG4105DIM ABC transporter GYK45_RS22510 ENOG4106A3M Cytochrome p-450 GYK45_RS22515 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS22530 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GYK45_RS22555 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GYK45_RS22570 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GYK45_RS22640 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GYK45_RS22650 ENOG4105CSH Transporter GYK45_RS22660 ENOG4105KNI merR family transcriptional Regulator GYK45_RS22665 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GYK45_RS22670 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GYK45_RS22675 ENOG4105CFG Acts as a chaperone (By similarity) GYK45_RS22680 ENOG4105DF6 Fe-S oxidoreductase GYK45_RS22685 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GYK45_RS22700 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GYK45_RS22705 ENOG4105DHP deoxycytidine triphosphate deaminase GYK45_RS22715 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A GYK45_RS22810 ENOG4107TXC Transcriptional regulator GYK45_RS22885 ENOG4105CJ1 ABC, transporter GYK45_RS22915 ENOG4108762 serine threonine protein kinase GYK45_RS22950 ENOG4107V2S Transcriptional regulator GYK45_RS22955 ENOG4105JAB phenazine biosynthesis protein, phzf family GYK45_RS22970 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) GYK45_RS23000 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GYK45_RS23005 ENOG4105F4R Transcriptional regulator mode GYK45_RS23025 ENOG4105MWK D-amino acid dehydrogenase, small subunit GYK45_RS23030 ENOG4105CTU Proline racemase GYK45_RS23100 ENOG4105K56 Transcriptional regulator GYK45_RS23140 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) GYK45_RS23160 ENOG4105DQE DNA ligase GYK45_RS23190 ENOG4105C9M aspartyl-trna synthetase GYK45_RS23230 ENOG4105CSU acyl-Coa dehydrogenase GYK45_RS23245 ENOG4105DFM M18 family aminopeptidase GYK45_RS23250 ENOG4105F0K SARP family transcriptional regulator GYK45_RS23290 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GYK45_RS23295 ENOG4105CPP Dehydrogenase, E1 component GYK45_RS23320 ENOG4107QPV Serine Threonine protein kinase GYK45_RS23325 ENOG4108VC7 Protein of unknown function (DUF2587) GYK45_RS23340 ENOG4107SVH Potassium channel protein GYK45_RS23350 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GYK45_RS23375 ENOG4108IG5 Transcriptional regulator GYK45_RS23380 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS23405 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GYK45_RS23410 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GYK45_RS23415 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GYK45_RS23420 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GYK45_RS23425 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GYK45_RS23435 ENOG4105VFE sira family GYK45_RS23450 ENOG4105KVH Transcriptional regulator GYK45_RS23455 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GYK45_RS23465 ENOG4105TV9 FHA Domain-Containing protein GYK45_RS23470 ENOG4105HZM Fha domain containing protein GYK45_RS23485 ENOG4105CJN penicillin-binding protein GYK45_RS23510 ENOG4108U4N (sortase) family GYK45_RS23520 ENOG4105ZJT Cell division protein CrgA GYK45_RS23540 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GYK45_RS23555 ENOG4108UGD Serine Threonine protein kinase GYK45_RS23580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GYK45_RS23585 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GYK45_RS23590 ENOG4105K7N UPF0232 protein GYK45_RS23595 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GYK45_RS23600 ENOG4108J5G 6-phosphogluconate dehydrogenase GYK45_RS23605 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GYK45_RS23615 ENOG41084CH 50S ribosomal protein l34 GYK45_RS23620 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GYK45_RS23625 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GYK45_RS23630 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GYK45_RS23640 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GYK45_RS23645 ENOG4107QJE Chromosome Partitioning Protein GYK45_RS23665 ENOG4105C3M thioredoxin reductase GYK45_RS23680 ENOG4105D9P serine threonine protein kinase GYK45_RS23695 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GYK45_RS23705 ENOG4105CZA synthase GYK45_RS23715 ENOG4105BZ4 penicillin-binding protein GYK45_RS23740 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GYK45_RS23745 ENOG4107YH6 single-stranded DNA-binding protein GYK45_RS23750 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GYK45_RS23755 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GYK45_RS23785 ENOG4107SET aldo keto reductase GYK45_RS23790 ENOG4105CHR reductase GYK45_RS23800 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GYK45_RS23810 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS23815 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GYK45_RS23885 ENOG4105C28 cystathionine GYK45_RS23890 ENOG4105KJF protein tyrosine phosphatase GYK45_RS23895 ENOG41082T9 Membrane GYK45_RS23900 ENOG4106048 Cupin 2, conserved barrel domain protein GYK45_RS23910 ENOG4105KF0 sporulation and cell division protein, SsgA GYK45_RS23925 ENOG4105FQP Beta-lactamase GYK45_RS23940 ENOG4107P2S Transcriptional regulator GYK45_RS23945 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS23950 ENOG4105C4M (Ubiquinol oxidase) subunit I GYK45_RS23955 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GYK45_RS23975 ENOG4108K4B hydrolase GYK45_RS23985 ENOG4105D0M Protease HtpX homolog GYK45_RS24000 ENOG4105CJ1 ABC, transporter GYK45_RS24025 ENOG4105DJ2 Major Facilitator Superfamily GYK45_RS24050 ENOG410667J hydrolase GYK45_RS24055 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GYK45_RS24060 ENOG4105CQC Prephenate dehydratase GYK45_RS24065 ENOG4105DBE peroxidase GYK45_RS24070 ENOG4105JDN Copper resistance protein GYK45_RS24110 ENOG4107T6F Xaa-Pro aminopeptidase GYK45_RS24125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GYK45_RS24140 ENOG4105C0H protease GYK45_RS24190 ENOG4108YZ4 nudix hydrolase GYK45_RS24250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GYK45_RS24300 ENOG4105NAF rna polymerase sigma factor GYK45_RS24305 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS24310 ENOG4105ES5 Histidine kinase GYK45_RS24360 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GYK45_RS24400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS24405 ENOG4105BZU Histidine kinase GYK45_RS24415 ENOG4105EDW glycosyl transferase, family 39 GYK45_RS24415 ENOG4105EDW glycosyl transferase, family 39 GYK45_RS24420 ENOG4105C57 major facilitator superfamily GYK45_RS24460 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS24465 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS24470 ENOG4105CTQ phosphohexokinase GYK45_RS24490 ENOG4108Z6B deaminase GYK45_RS24500 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GYK45_RS24520 ENOG4106A3M Cytochrome p-450 GYK45_RS24540 ENOG4108TGC Acyltransferase GYK45_RS24545 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GYK45_RS24550 ENOG4105DV0 amidase (EC 3.5.1.4 GYK45_RS24555 ENOG4105MWK D-amino acid dehydrogenase, small subunit GYK45_RS24575 ENOG4107R37 Glutamate dehydrogenase GYK45_RS24580 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS24590 ENOG4108S01 response regulator GYK45_RS24595 ENOG4105BZU Histidine kinase GYK45_RS24610 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS24615 ENOG4105BZU Histidine kinase GYK45_RS24690 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GYK45_RS24695 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GYK45_RS24705 ENOG4105CFH Aspartokinase GYK45_RS24800 ENOG4105BZ4 penicillin-binding protein GYK45_RS24835 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GYK45_RS24850 ENOG4105P8F nudix hydrolase GYK45_RS24865 ENOG4105D74 hydrolase GYK45_RS24875 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GYK45_RS24880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS24885 ENOG4107B2H carbonic anhydrase GYK45_RS24975 ENOG4105WN5 stage II sporulation protein GYK45_RS24980 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GYK45_RS24985 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GYK45_RS25010 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GYK45_RS25045 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS25055 ENOG4105YVS arsR family transcriptional regulator GYK45_RS25065 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS25095 ENOG4105ENE Histidine kinase GYK45_RS25100 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS25105 ENOG410841Q phosphoesterase PA-phosphatase related protein GYK45_RS25155 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS25175 ENOG4105EMN RNA polymerase sigma factor GYK45_RS25195 ENOG4105C2M dna polymerase I GYK45_RS25220 ENOG4105C26 Dehydrogenase GYK45_RS25250 ENOG4105CVK Glutamate decarboxylase GYK45_RS25255 ENOG4108NIW Leucine export protein LeuE GYK45_RS25260 ENOG4107TXC Transcriptional regulator GYK45_RS25275 ENOG4105F0N pyrophosphate phospho-hydrolase GYK45_RS25315 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GYK45_RS25345 ENOG4108IJ8 ABC transporter GYK45_RS25350 ENOG4105E90 ABC transporter GYK45_RS25355 ENOG4105E90 ABC transporter GYK45_RS25370 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS25385 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS25390 ENOG4105YVS arsR family transcriptional regulator GYK45_RS25395 ENOG41082SX arsR family transcriptional regulator GYK45_RS25410 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GYK45_RS25415 ENOG4108IYU L-aspartate oxidase GYK45_RS25425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GYK45_RS25460 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GYK45_RS25505 ENOG4105CGH 5'-nucleotidase GYK45_RS25510 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GYK45_RS25515 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GYK45_RS25530 ENOG4108FN7 Aldo keto reductase GYK45_RS25550 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GYK45_RS25555 ENOG4108YZJ Pfam:DUF2596 GYK45_RS25560 ENOG4105DDI hemolysin-type calcium-binding region GYK45_RS25585 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYK45_RS25600 ENOG4105K64 Glycosyl transferase, family 2 GYK45_RS25605 ENOG4105YVS arsR family transcriptional regulator GYK45_RS25630 ENOG4107SQD Transcriptional regulator, GntR family GYK45_RS25665 ENOG4105BZU Histidine kinase GYK45_RS25685 ENOG4108VJ1 Transcriptional regulator (CarD family GYK45_RS25690 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GYK45_RS25695 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GYK45_RS25700 ENOG4105C8N cysteinyl-tRNA synthetase GYK45_RS25705 ENOG4105C2N RNA methyltransferase TrmH family group 3 GYK45_RS25725 ENOG4108IJ9 (ABC) transporter GYK45_RS25740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS25760 ENOG4105CJA serine threonine protein kinase GYK45_RS25765 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS25835 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYK45_RS25870 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GYK45_RS25875 ENOG4105CHR reductase GYK45_RS25930 ENOG4106A3M Cytochrome p-450 GYK45_RS25955 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS25970 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS25975 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS25980 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS25995 ENOG4105MXW flavin reductase domain protein, FMN-binding GYK45_RS26000 ENOG4105C5X domain protein GYK45_RS26015 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS26035 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GYK45_RS26045 ENOG4105BZU Histidine kinase GYK45_RS26060 ENOG4105CE4 GlcNAc 6-P deacetylase GYK45_RS26090 ENOG4105C3Q Glycosyl transferase, family 2 GYK45_RS26105 ENOG4105VEQ Cold shock protein GYK45_RS26110 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GYK45_RS26115 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GYK45_RS26120 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GYK45_RS26155 ENOG4106N3A copper homeostasis protein cutc GYK45_RS26165 ENOG4105EEM helicase GYK45_RS26175 ENOG4105CFI type iii restriction protein res subunit GYK45_RS26195 ENOG4105E0A ABC, transporter GYK45_RS26200 ENOG4105TVJ transport system, permease GYK45_RS26205 ENOG4105DQ5 transport system permease protein GYK45_RS26220 ENOG4105VEQ Cold shock protein GYK45_RS26225 ENOG4105E63 Pfam:DUF178 GYK45_RS26230 ENOG4108UIH futalosine nucleosidase GYK45_RS26265 ENOG4105C7N Xanthine uracil vitamin C permease GYK45_RS26285 ENOG4105CPC Aldo Keto reductase GYK45_RS26300 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GYK45_RS26305 ENOG4105CQB FAD linked oxidase domain protein GYK45_RS26320 ENOG4107QX3 carboxylase GYK45_RS26335 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS26340 ENOG41060WC Enoyl-CoA hydratase GYK45_RS26345 ENOG4108IG5 Transcriptional regulator GYK45_RS26355 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GYK45_RS26365 ENOG4108SU4 UPF0309 protein GYK45_RS26375 ENOG4108XEP Alpha Beta Hydrolase Fold protein GYK45_RS26385 ENOG4105DMF Dehydrogenase GYK45_RS26455 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS26505 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GYK45_RS26530 ENOG4107TPY serine threonine protein kinase GYK45_RS26620 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GYK45_RS26645 ENOG4105CMV Succinyl-CoA synthetase subunit beta GYK45_RS26670 ENOG4105DC1 bifunctional purine biosynthesis protein purh GYK45_RS26675 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GYK45_RS26690 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GYK45_RS26715 ENOG4105C26 Dehydrogenase GYK45_RS26725 ENOG4108IJ7 Glycine betaine GYK45_RS26730 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component GYK45_RS26745 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS26750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYK45_RS26760 ENOG4106032 Glutathionylspermidine synthase GYK45_RS26765 ENOG4105C8Y Acetylornithine aminotransferase GYK45_RS26770 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GYK45_RS26780 ENOG4105C31 Tryptophanyl-tRNA synthetase GYK45_RS26795 ENOG4107H3J ribonuclease GYK45_RS26840 ENOG4105E2D ec 3.2.1.52 GYK45_RS26850 ENOG4108MMM RNA Polymerase GYK45_RS26900 ENOG4107QJZ Glycosyl transferase, family 2 GYK45_RS26905 ENOG4108KGH TRANSCRIPTIONal GYK45_RS26935 ENOG4108M8W Monooxygenase GYK45_RS26940 ENOG4105FDP GntR family transcriptional regulator GYK45_RS26945 ENOG41067V3 Antibiotic biosynthesis monooxygenase GYK45_RS26950 ENOG4107RGD Major Facilitator superfamily GYK45_RS26975 ENOG4105C6F GntR Family Transcriptional Regulator GYK45_RS26980 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GYK45_RS26985 ENOG4105C6Z Gluconate GYK45_RS26990 ENOG4105CHR reductase GYK45_RS26995 ENOG4105CPQ Dehydrogenase GYK45_RS27010 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GYK45_RS27020 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYK45_RS27030 ENOG4108XFH Transcriptional regulator GYK45_RS27035 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GYK45_RS27050 ENOG4107QRS glycosyltransferase group 2 family protein GYK45_RS27060 ENOG4105F0R Cytidylyltransferase GYK45_RS27065 ENOG4105D2T synthase GYK45_RS27075 ENOG4107RM1 amidohydrolase GYK45_RS27080 ENOG4105DIH basic membrane GYK45_RS27085 ENOG4108JQ9 ABC transporter GYK45_RS27090 ENOG4105UIB (ABC) transporter GYK45_RS27110 ENOG4107RSM transcriptional regulator GYK45_RS27115 ENOG4105D94 Major Facilitator Superfamily GYK45_RS27125 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GYK45_RS27150 ENOG41065SU Two-component system sensor kinase GYK45_RS27155 ENOG4108KXV response regulator GYK45_RS27160 ENOG4105NAF rna polymerase sigma factor GYK45_RS27175 ENOG4105GAK amidohydrolase 2 GYK45_RS27180 ENOG4105KHM amidohydrolase 2 GYK45_RS27185 ENOG4105C26 Dehydrogenase GYK45_RS27190 ENOG4105C26 Dehydrogenase GYK45_RS27240 ENOG4108JIK carboxylase GYK45_RS27250 ENOG4107WR6 Maf-like protein GYK45_RS27260 ENOG4105D8K carboxyl transferase GYK45_RS27270 ENOG4108QER Adenylate cyclase GYK45_RS27280 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS27285 ENOG4105KDM Diguanylate cyclase with gaf sensor GYK45_RS27290 ENOG4105C84 Histidine ammonia-lyase GYK45_RS27340 ENOG4105C0F tryptophanase EC 4.1.99.1 GYK45_RS27375 ENOG4106A3M Cytochrome p-450 GYK45_RS27390 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GYK45_RS27410 ENOG4105CEP NADH dehydrogenase GYK45_RS27415 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GYK45_RS27420 ENOG4107RBB ABC transporter, permease GYK45_RS27425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS27455 ENOG4105CHU acetyl-coa acetyltransferase GYK45_RS27470 ENOG4108J2R molybdopterin oxidoreductase GYK45_RS27480 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS27485 ENOG4105ETS cytosine purines uracil thiamine allantoin GYK45_RS27495 ENOG4105E90 ABC transporter GYK45_RS27500 ENOG4105E90 ABC transporter GYK45_RS27505 ENOG4108IJ8 ABC transporter GYK45_RS27510 ENOG4105C84 Histidine ammonia-lyase GYK45_RS27580 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GYK45_RS27585 ENOG41082AN stage II sporulation protein GYK45_RS27620 ENOG4105DUX Transporter GYK45_RS27625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS27630 ENOG41065SU Two-component system sensor kinase GYK45_RS27655 ENOG4105C6Y Udp-glucose 6-dehydrogenase GYK45_RS27665 ENOG4108KGH TRANSCRIPTIONal GYK45_RS27670 ENOG4108S4H thioesterase Superfamily protein GYK45_RS27675 ENOG4108KGH TRANSCRIPTIONal GYK45_RS27690 ENOG4108KGH TRANSCRIPTIONal GYK45_RS27695 ENOG4107TB5 TRANSCRIPTIONal GYK45_RS27720 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) GYK45_RS27725 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase GYK45_RS27730 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GYK45_RS27735 ENOG4107RGC Glycosyl transferase, family 2 GYK45_RS27755 ENOG4105DAA L-lactate GYK45_RS27760 ENOG4107QKV phosphomannomutase GYK45_RS27765 ENOG4105W49 UPF0434 protein GYK45_RS27775 ENOG4105EIP mannose-6-phosphate isomerase GYK45_RS27785 ENOG4105DM4 PTS System GYK45_RS27820 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GYK45_RS27825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS27830 ENOG4105BZU Histidine kinase GYK45_RS27835 ENOG4105G3P Lipoprotein lpqB GYK45_RS27845 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GYK45_RS27855 ENOG4105T0Z Conserved Protein GYK45_RS27865 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GYK45_RS27880 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GYK45_RS27885 ENOG4107RKG DJ-1/PfpI family GYK45_RS27890 ENOG4105C7I Dehydrogenase GYK45_RS27895 ENOG4107SJB teichoic acid biosynthesis GYK45_RS27940 ENOG4107SJB teichoic acid biosynthesis GYK45_RS27995 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GYK45_RS28020 ENOG4108UGD Serine Threonine protein kinase GYK45_RS28025 ENOG4108QVN serine threonine protein kinase GYK45_RS28030 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GYK45_RS28045 ENOG4105CAK Cell division ATP-binding protein ftsE GYK45_RS28055 ENOG4105CN1 protease GYK45_RS28060 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GYK45_RS28095 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GYK45_RS28100 ENOG4105CJQ hydrolase, family 31 GYK45_RS28105 ENOG4105I1K ABC transporter GYK45_RS28120 ENOG4107RSM transcriptional regulator GYK45_RS28135 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS28150 ENOG4105DQQ Major facilitator superfamily MFS_1 GYK45_RS28175 ENOG4105EEM helicase GYK45_RS28180 ENOG4105VEQ Cold shock protein GYK45_RS28190 ENOG4108426 dNA-binding protein GYK45_RS28195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GYK45_RS28220 ENOG4105D56 permease protein GYK45_RS28225 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GYK45_RS28230 ENOG4105E2D ec 3.2.1.52 GYK45_RS28245 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GYK45_RS28250 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS28265 ENOG4105NI8 Cytosine-specific methyltransferase GYK45_RS28280 ENOG4105NI8 Cytosine-specific methyltransferase GYK45_RS28285 ENOG4108X79 transcriptional regulator GYK45_RS28370 ENOG4106CY5 excisionase GYK45_RS28375 ENOG4107T65 Integrase GYK45_RS28405 ENOG4107ZR7 Membrane GYK45_RS28420 ENOG41086VY Fic/DOC family GYK45_RS28460 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GYK45_RS28475 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS28505 ENOG4107G87 m6 family metalloprotease domain protein GYK45_RS28515 ENOG4108RWI nicotinamidase GYK45_RS28525 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GYK45_RS28565 ENOG4105CI1 PTS System GYK45_RS28570 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GYK45_RS28580 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GYK45_RS28600 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GYK45_RS28635 ENOG4106BRA Membrane GYK45_RS28640 ENOG4108U4N (sortase) family GYK45_RS28650 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GYK45_RS28660 ENOG41090KN UPF0303 protein GYK45_RS28665 ENOG4105D9R oxidoreductase GYK45_RS28705 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GYK45_RS28715 ENOG4105JXH GntR family transcriptional regulator GYK45_RS28735 ENOG4105ESF Peptidoglycan binding domain protein GYK45_RS28750 ENOG4105CHR reductase GYK45_RS28755 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GYK45_RS28790 ENOG4108M1A Chitin-binding protein GYK45_RS28825 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component GYK45_RS28830 ENOG4107XKF NMT1 THI5 Like Domain Protein GYK45_RS28845 ENOG4105CPQ Dehydrogenase GYK45_RS28850 ENOG4105C57 major facilitator superfamily GYK45_RS28865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYK45_RS28870 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYK45_RS28895 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GYK45_RS28920 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GYK45_RS28935 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GYK45_RS28940 ENOG4105CHR reductase GYK45_RS28955 ENOG4108JIK carboxylase GYK45_RS29030 ENOG4105RE0 Asp Glu hydantoin racemase GYK45_RS29040 ENOG4105DBE peroxidase GYK45_RS29045 ENOG4105HSS phospholipase C GYK45_RS29050 ENOG4105DEN Luciferase family GYK45_RS29055 ENOG4105BZU Histidine kinase GYK45_RS29075 ENOG4105BZU Histidine kinase GYK45_RS29100 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS29150 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYK45_RS29175 ENOG4108RQS Two component transcriptional regulator (Winged helix family GYK45_RS29180 ENOG410804D Sensor Signal Transduction Histidine Kinase GYK45_RS29190 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GYK45_RS29215 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS29220 ENOG41065HY 1,4-beta-cellobiosidase GYK45_RS29230 ENOG4105CYP glycoside hydrolase, family GYK45_RS29255 ENOG4108Z6Z Transcriptional regulator GYK45_RS29280 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS29295 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GYK45_RS29310 ENOG4105E2D ec 3.2.1.52 GYK45_RS29315 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS29320 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GYK45_RS29335 ENOG4107QX3 carboxylase GYK45_RS29350 ENOG4105C29 acyl-CoA thioesterase GYK45_RS29355 ENOG4108XFF GYK45_RS29365 ENOG4105VEQ Cold shock protein GYK45_RS29390 ENOG4108FKE two-component system sensor kinase GYK45_RS29395 ENOG4108PYU two-component system response regulator GYK45_RS29415 ENOG4105BZU Histidine kinase GYK45_RS29420 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS29470 ENOG4108594 Permease of the drug metabolite transporter GYK45_RS29485 ENOG4108FN7 Aldo keto reductase GYK45_RS29495 ENOG410645S MarR family Transcriptional regulator GYK45_RS29510 ENOG41060NJ transcriptional regulator GYK45_RS29535 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS29540 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GYK45_RS29605 ENOG4105NAF rna polymerase sigma factor GYK45_RS29615 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GYK45_RS29625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GYK45_RS29630 ENOG4105C2J ABC transporter GYK45_RS29640 ENOG4105C7H Helicase, RecD TraA family GYK45_RS29665 ENOG4107R13 MMPL domain protein GYK45_RS29675 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYK45_RS29685 ENOG4105C2J ABC transporter GYK45_RS29700 ENOG4105EDK PfkB domain protein GYK45_RS29710 ENOG4105DH8 myo-inositol catabolism GYK45_RS29715 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GYK45_RS29720 ENOG4105C26 Dehydrogenase GYK45_RS29750 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS29755 ENOG4105ENE Histidine kinase GYK45_RS29765 ENOG410905X membrane-flanked domain protein GYK45_RS29835 ENOG4105CJ1 ABC, transporter GYK45_RS29845 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS29875 ENOG4105KJJ Uncharacterized ACR, COG1993 GYK45_RS29885 ENOG4105EAH synthase GYK45_RS29890 ENOG4105WQT MbtH domain protein GYK45_RS29900 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GYK45_RS29955 ENOG4105VHU single-stranded DNA-binding protein GYK45_RS29990 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GYK45_RS30020 ENOG4105CT1 (ABC) transporter GYK45_RS30055 ENOG4105E2R ROK family GYK45_RS30065 ENOG4105D8X mechanosensitive ion channel GYK45_RS30135 ENOG4105MC2 DSBA oxidoreductase GYK45_RS30145 ENOG4105C85 amino acid GYK45_RS30150 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GYK45_RS30185 ENOG4105C85 amino acid GYK45_RS30220 ENOG4108TGC Acyltransferase GYK45_RS30240 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GYK45_RS30245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GYK45_RS30250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GYK45_RS30255 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GYK45_RS30280 ENOG4105CJN penicillin-binding protein GYK45_RS30285 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GYK45_RS30295 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GYK45_RS30320 ENOG4105CNI cell division protein FtsW GYK45_RS30345 ENOG4105C03 ribonuclease GYK45_RS30350 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GYK45_RS30355 ENOG4105K46 50S ribosomal protein l27 GYK45_RS30360 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GYK45_RS30370 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GYK45_RS30395 ENOG4105D0M Protease HtpX homolog GYK45_RS30400 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GYK45_RS30415 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYK45_RS30445 ENOG4105C8T Leucyl-tRNA synthetase GYK45_RS30455 ENOG4105EPR degv family GYK45_RS30460 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GYK45_RS30530 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GYK45_RS30535 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GYK45_RS30540 ENOG4108IQE Amp-dependent synthetase and ligase GYK45_RS30565 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GYK45_RS30570 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GYK45_RS30575 ENOG4107QWG 2-Nitropropane dioxygenase GYK45_RS30590 ENOG4107YU2 histidine triad (hIT) protein GYK45_RS30595 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GYK45_RS30610 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GYK45_RS30635 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GYK45_RS30650 ENOG4105D4Y metalloprotease GYK45_RS30655 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GYK45_RS30665 ENOG4105EYF MMPL domain protein GYK45_RS30670 ENOG4105BZU Histidine kinase GYK45_RS30675 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS30700 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GYK45_RS30715 ENOG4105MSB protein, conserved in bacteria GYK45_RS30770 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GYK45_RS30775 ENOG4105CPC Aldo Keto reductase GYK45_RS30855 ENOG4105FDK ABC transporter GYK45_RS30865 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GYK45_RS30880 ENOG4108FN7 Aldo keto reductase GYK45_RS30925 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GYK45_RS30955 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS30960 ENOG4105BZU Histidine kinase GYK45_RS30975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GYK45_RS30985 ENOG4105DRS transport system, permease GYK45_RS31000 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GYK45_RS31005 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GYK45_RS31020 ENOG4105CHU acetyl-coa acetyltransferase GYK45_RS31035 ENOG41067TZ transcriptional regulator, MarR family GYK45_RS31040 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GYK45_RS31055 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GYK45_RS31065 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS31075 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS31095 ENOG4107QZF nitrite reductase NADPH large subunit GYK45_RS31100 ENOG4107QZF nitrite reductase NADPH large subunit GYK45_RS31140 ENOG4105BZU Histidine kinase GYK45_RS31145 ENOG4105ETX regulatoR GYK45_RS31195 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GYK45_RS31205 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GYK45_RS31280 ENOG4105EQK -acetyltransferase GYK45_RS31295 ENOG41080RH Thioredoxin GYK45_RS31300 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GYK45_RS31315 ENOG4107HP6 Transcriptional regulator GYK45_RS31320 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GYK45_RS31390 ENOG4105YVS arsR family transcriptional regulator GYK45_RS31410 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GYK45_RS31435 ENOG4105NGS secreted protein GYK45_RS31440 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GYK45_RS31445 ENOG4108HWW ABC transporter GYK45_RS31450 ENOG4105C2J ABC transporter GYK45_RS31495 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GYK45_RS31515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GYK45_RS31520 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYK45_RS31525 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GYK45_RS31550 ENOG4105VUF Transcriptional regulator GYK45_RS31555 ENOG4105CPC Aldo Keto reductase GYK45_RS31565 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS31570 ENOG4108ZGX Histidine kinase GYK45_RS31600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GYK45_RS31680 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GYK45_RS31725 ENOG4105BZU Histidine kinase GYK45_RS31730 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS31785 ENOG41090MY MarR family Transcriptional regulator GYK45_RS31790 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GYK45_RS31800 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GYK45_RS31810 ENOG4105DNP FAD linked oxidase domain protein GYK45_RS31815 ENOG4108IXY short-chain dehydrogenase reductase GYK45_RS31835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GYK45_RS31840 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GYK45_RS31855 ENOG4105WBV Transcriptional regulator GYK45_RS31870 ENOG4105EGE secreted protein GYK45_RS31955 ENOG4107S1E Beta-lactamase GYK45_RS31960 ENOG4105C22 threonyL-tRNA synthetase GYK45_RS31980 ENOG4105BZU Histidine kinase GYK45_RS31985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS32005 ENOG4105CIR epoxide hydrolase GYK45_RS32030 ENOG41075H3 AraC family transcriptional regulator GYK45_RS32055 ENOG4105F2C Acetyl-CoA acetyltransferase GYK45_RS32065 ENOG4105BZ1 (ABC) transporter GYK45_RS32120 ENOG4108SGK Tetr family transcriptional regulator GYK45_RS32125 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GYK45_RS32130 ENOG4107QVI Methyltransferase, type 11 GYK45_RS32145 ENOG4105DYW oxidoreductase GYK45_RS32155 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase GYK45_RS32170 ENOG4105BZU Histidine kinase GYK45_RS32180 ENOG4107QPD alcohol dehydrogenase GYK45_RS32185 ENOG4105CHR reductase GYK45_RS32200 ENOG4108MES Periplasmic binding protein GYK45_RS32205 ENOG4105EGD dinuclear metal center protein, YbgI family GYK45_RS32215 ENOG4105CVJ phosphoglycerate mutase GYK45_RS32220 ENOG4108UHU Aldolase GYK45_RS32225 ENOG4107XFJ UPF0246 protein GYK45_RS32245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GYK45_RS32250 ENOG4105DND Transcriptional regulator GYK45_RS32255 ENOG4105EBM Alpha Beta Hydrolase Fold protein GYK45_RS32270 ENOG4107258 Transcriptional regulator GYK45_RS32320 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS32325 ENOG4105DGI Alkaline phosphatase GYK45_RS32335 ENOG4105C2C drug resistance transporter, Bcr CflA GYK45_RS32340 ENOG4107S1E Beta-lactamase GYK45_RS32360 ENOG4106A0S GYK45_RS32370 ENOG4105DBE peroxidase GYK45_RS32375 ENOG410650H (LipO)protein GYK45_RS32410 ENOG4108478 ec 3.2.1.18 GYK45_RS32420 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component GYK45_RS32440 ENOG4107XZ0 Peptidase M50 GYK45_RS32460 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GYK45_RS32465 ENOG4105C57 major facilitator superfamily GYK45_RS32470 ENOG4108JGH Tetr family transcriptional regulator GYK45_RS32480 ENOG4105F27 Major Facilitator GYK45_RS32485 ENOG4107S9D Alpha beta hydrolase GYK45_RS32490 ENOG4105C4K Nad synthetase GYK45_RS32495 ENOG4107R16 Multicopper oxidase GYK45_RS32500 ENOG4105C5F glutamine synthetase GYK45_RS32505 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GYK45_RS32545 ENOG4108SGR YheO domain-containing protein GYK45_RS32555 ENOG4105DQF Hydrolase GYK45_RS32565 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS32575 ENOG4107FKK extracellular solute-binding protein family 1 GYK45_RS32580 ENOG4105D56 permease protein GYK45_RS32585 ENOG4105EG2 ABC transporter, permease GYK45_RS32600 ENOG4105CPQ Dehydrogenase GYK45_RS32650 ENOG4107NHD transcriptional regulator GYK45_RS32670 ENOG4105CSH Transporter GYK45_RS32700 ENOG4105F0N pyrophosphate phospho-hydrolase GYK45_RS32710 ENOG410829K Lysine exporter protein (Lyse ygga) GYK45_RS32750 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GYK45_RS32765 ENOG4108ZHR arsR family transcriptional regulator GYK45_RS32795 ENOG4105CHR reductase GYK45_RS32805 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GYK45_RS32825 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GYK45_RS32830 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GYK45_RS32835 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GYK45_RS32875 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS32880 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GYK45_RS32905 ENOG4105C3J Cysteine desulfurase GYK45_RS32910 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GYK45_RS32915 ENOG4105BZ9 Cytochrome C oxidase, subunit I GYK45_RS32920 ENOG4105MCD Part of cytochrome c oxidase, its function is GYK45_RS32935 ENOG4105CCU oxidase (Subunit III) GYK45_RS32940 ENOG4107UDY cytochrome C GYK45_RS32945 ENOG4107EUI c reductase, iron-sulfur GYK45_RS32950 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GYK45_RS32955 ENOG4108I0Q anthranilate phosphoribosyltransferase GYK45_RS33030 ENOG4105DKQ ROK family GYK45_RS33060 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS33065 ENOG4105CTQ phosphohexokinase GYK45_RS33085 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GYK45_RS33095 ENOG4108UQY Iron-storage protein GYK45_RS33110 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GYK45_RS33130 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GYK45_RS33145 ENOG4107QZF nitrite reductase NADPH large subunit GYK45_RS33155 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GYK45_RS33175 ENOG4107Z3H Transcriptional regulator, TetR family GYK45_RS33185 ENOG4105C2J ABC transporter GYK45_RS33215 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GYK45_RS33235 ENOG4105CJN penicillin-binding protein GYK45_RS33240 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GYK45_RS33250 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GYK45_RS33275 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GYK45_RS33280 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GYK45_RS33285 ENOG4105DFA alanine racemase domain protein GYK45_RS33290 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GYK45_RS33305 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GYK45_RS33310 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GYK45_RS33365 ENOG4105C0B DNA polymerase III (alpha subunit) GYK45_RS33405 ENOG4108Z66 YbaK ebsC protein GYK45_RS33410 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GYK45_RS33425 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS33430 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GYK45_RS33440 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GYK45_RS33445 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GYK45_RS33450 ENOG4108176 endoribonuclease L-psp GYK45_RS33455 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GYK45_RS33465 ENOG4105EMN RNA polymerase sigma factor GYK45_RS33470 ENOG4108Z6Z Transcriptional regulator GYK45_RS33475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS33505 ENOG4107SVN transposase GYK45_RS33510 ENOG4105EMU Dehydrogenase GYK45_RS33530 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GYK45_RS33535 ENOG4105CRQ synthase (Component I) GYK45_RS33555 ENOG4105DK0 Indole-3-glycerol phosphate synthase GYK45_RS33560 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GYK45_RS33565 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GYK45_RS33575 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GYK45_RS33585 ENOG4105CBC glutamate synthase GYK45_RS33595 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GYK45_RS33600 ENOG4105CZV ABC transporter GYK45_RS33620 ENOG410905P Pyridoxamine 5-phosphate GYK45_RS33640 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GYK45_RS33655 ENOG4105DY8 decarboxylase GYK45_RS33665 ENOG4105CGH 5'-nucleotidase GYK45_RS33695 ENOG4108IV0 ABC, transporter GYK45_RS33700 ENOG4105C0Z ABC transporter GYK45_RS33705 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GYK45_RS33710 ENOG4105C32 Amino acid ABC transporter (Permease) GYK45_RS33725 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GYK45_RS33770 ENOG4105CQ7 ATP-dependent helicase GYK45_RS33795 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GYK45_RS33850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GYK45_RS33860 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GYK45_RS33880 ENOG4105CSH Transporter GYK45_RS33895 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GYK45_RS33915 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GYK45_RS33920 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GYK45_RS33925 ENOG4105CHW UPF0052 protein GYK45_RS33940 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GYK45_RS33945 ENOG4105BZA Phosphoglycerate kinase GYK45_RS33950 ENOG4105CP7 Triose-phosphate isomerase GYK45_RS33970 ENOG4107QP8 phosphohexose isomerase GYK45_RS33975 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GYK45_RS33990 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GYK45_RS34000 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GYK45_RS34015 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GYK45_RS34040 ENOG4105JRK feS assembly protein SufD GYK45_RS34050 ENOG4105C3K feS assembly ATPase SufC GYK45_RS34060 ENOG4108UNV SUF system FeS assembly protein, NifU family GYK45_RS34065 ENOG4105VG1 fes assembly suf system protein GYK45_RS34070 ENOG410814C multidrug resistance protein GYK45_RS34135 ENOG41080V3 Major Facilitator superfamily GYK45_RS34140 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GYK45_RS34145 ENOG41061H0 Monooxygenase GYK45_RS34155 ENOG4105E9Z Nad-dependent epimerase dehydratase GYK45_RS34185 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GYK45_RS34220 ENOG4108ZJ4 polysaccharide deacetylase GYK45_RS34250 ENOG4107HP6 Transcriptional regulator GYK45_RS34260 ENOG4105C9B Cysteine desulfurase GYK45_RS34265 ENOG4105EV8 ectoine hydroxylase GYK45_RS34270 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GYK45_RS34280 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GYK45_RS34290 ENOG4105I6B RNA polymerase GYK45_RS34310 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GYK45_RS34325 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GYK45_RS34340 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GYK45_RS34350 ENOG4107W7X Aldolase GYK45_RS34365 ENOG4105C5H ABC transporter GYK45_RS34385 ENOG4105BZU Histidine kinase GYK45_RS34390 ENOG4105BZU Histidine kinase GYK45_RS34430 ENOG4105BZP glycoside hydrolase 15-related GYK45_RS34445 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GYK45_RS34470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GYK45_RS34480 ENOG4107QN1 sodium solute GYK45_RS34485 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GYK45_RS34505 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GYK45_RS34560 ENOG4105CHR reductase GYK45_RS34565 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GYK45_RS34575 ENOG4107YCY Transcriptional regulator GYK45_RS34580 ENOG4105DJ2 Major Facilitator Superfamily GYK45_RS34600 ENOG4105EAC phosphoserine phosphatase GYK45_RS34610 ENOG4105IDI abc transporter atp-binding protein GYK45_RS34625 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS34635 ENOG4108UF8 GYK45_RS34640 ENOG4105DKW ABC transporter GYK45_RS34660 ENOG4108V1U phospholipid-binding protein GYK45_RS34675 ENOG4108VX5 3-methyladenine DNA glycosylase GYK45_RS34710 ENOG4105DQ5 transport system permease protein GYK45_RS34745 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GYK45_RS34750 ENOG4107QPH glycogen) synthase GYK45_RS34765 ENOG4105BZP glycoside hydrolase 15-related GYK45_RS34775 ENOG4108YZ4 nudix hydrolase GYK45_RS34785 ENOG4105DCF alanine dehydrogenase GYK45_RS34800 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GYK45_RS34805 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GYK45_RS34810 ENOG4105FE9 pseudouridine synthase GYK45_RS34825 ENOG4105CAT Cytidine monophosphate kinase GYK45_RS34835 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GYK45_RS34850 ENOG4108I69 Glycosyl transferases group 1 GYK45_RS34865 ENOG4105BZ9 Cytochrome C oxidase, subunit I GYK45_RS34875 ENOG4107ETC gas vesicle protein GYK45_RS34885 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) GYK45_RS34900 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth GYK45_RS34915 ENOG410841Q phosphoesterase PA-phosphatase related protein GYK45_RS34925 ENOG4105C57 major facilitator superfamily GYK45_RS34930 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS34935 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GYK45_RS34955 ENOG4105CDA abc transporter atp-binding protein GYK45_RS34960 ENOG4105EAB amino acid AbC transporter GYK45_RS34965 ENOG4105CPU Monooxygenase GYK45_RS34970 ENOG4105CPU Monooxygenase GYK45_RS34975 ENOG4106NMR serine protease GYK45_RS34995 ENOG410905P Pyridoxamine 5-phosphate GYK45_RS35005 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GYK45_RS35025 ENOG4108ZHJ Organic hydroperoxide resistance protein GYK45_RS35030 ENOG4105K56 Transcriptional regulator GYK45_RS35060 ENOG4105DBM Siderophore biosynthesis protein GYK45_RS35065 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GYK45_RS35075 ENOG41063TF transcriptional regulator (AraC GYK45_RS35095 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GYK45_RS35120 ENOG4105CHR reductase GYK45_RS35135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS35170 ENOG4105EYF MMPL domain protein GYK45_RS35175 ENOG4105BZU Histidine kinase GYK45_RS35190 ENOG4105D94 Major Facilitator Superfamily GYK45_RS35225 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GYK45_RS35230 ENOG4106V2I dimethylaminohydrolase GYK45_RS35260 ENOG4108TCJ secreted hydrolase GYK45_RS35265 ENOG41061MD high-affinity nickel-transporter GYK45_RS35290 ENOG4105FDP GntR family transcriptional regulator GYK45_RS35295 ENOG4105F1J Homogentisate 1,2-dioxygenase GYK45_RS35300 ENOG4108SGK Tetr family transcriptional regulator GYK45_RS35305 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GYK45_RS35310 ENOG4105D4T Citrate transporter GYK45_RS35335 ENOG4107R13 MMPL domain protein GYK45_RS35345 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS35365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GYK45_RS35375 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GYK45_RS35425 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS35465 ENOG4105JP4 Inner membrane protein yidG GYK45_RS35470 ENOG4105VG5 Membrane GYK45_RS35475 ENOG4105PTV Nudix Hydrolase GYK45_RS35500 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GYK45_RS35510 ENOG4107TYR Glycosyl Transferase GYK45_RS35530 ENOG4107S9F NmrA family GYK45_RS35550 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GYK45_RS35555 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GYK45_RS35560 ENOG4107QJN gtp cyclohydrolase ii GYK45_RS35580 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GYK45_RS35600 ENOG4105EMU Dehydrogenase GYK45_RS35645 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GYK45_RS35650 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GYK45_RS35655 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GYK45_RS35695 ENOG4105CPC Aldo Keto reductase GYK45_RS35700 ENOG4105DYW oxidoreductase GYK45_RS35715 ENOG4105D7N magnesium and cobalt transport protein CorA GYK45_RS35735 ENOG4105C8N cysteinyl-tRNA synthetase GYK45_RS35760 ENOG4105C2J ABC transporter GYK45_RS35765 ENOG4108HWV )-transporter GYK45_RS35780 ENOG4105JXH GntR family transcriptional regulator GYK45_RS35790 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GYK45_RS35795 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS35800 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS35805 ENOG4108K8U Glycerol operon regulatory protein GYK45_RS35810 ENOG4105C3R Methionine synthase GYK45_RS35815 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GYK45_RS35860 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GYK45_RS35865 ENOG4105E5F proteasome GYK45_RS35870 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GYK45_RS35875 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GYK45_RS35880 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GYK45_RS35885 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS35895 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GYK45_RS35900 ENOG4108V1T peptidylprolyl cis-trans isomerase GYK45_RS35910 ENOG4108FFZ Transcriptional regulator GYK45_RS35930 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GYK45_RS35935 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GYK45_RS35960 ENOG4105HFS 5'-3' exonuclease GYK45_RS35965 ENOG4108IJ7 Glycine betaine GYK45_RS35990 ENOG4105CI2 imidazolone-5-propionate hydrolase GYK45_RS35995 ENOG4105E5G Alpha beta hydrolase fold GYK45_RS36040 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GYK45_RS36095 ENOG4105BZU Histidine kinase GYK45_RS36100 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS36105 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GYK45_RS36125 ENOG4105VEQ Cold shock protein GYK45_RS36130 ENOG4105C1J atp-dependent rna helicase GYK45_RS36155 ENOG4105CUB amino acid GYK45_RS36160 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) GYK45_RS36165 ENOG4105DND Transcriptional regulator GYK45_RS36250 ENOG41089UC methyltransferase, type 11 GYK45_RS36260 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS36270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GYK45_RS36300 ENOG4108IUS Transketolase GYK45_RS36305 ENOG4108HHA Transketolase GYK45_RS36310 ENOG4105CM2 brancheD-chain amino acid aminotransferase GYK45_RS36340 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GYK45_RS36345 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYK45_RS36375 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS36390 ENOG4107SGM protein serine threonine phosphatase GYK45_RS36400 ENOG4105E2A Dehydrogenase GYK45_RS36405 ENOG4105CFG Acts as a chaperone (By similarity) GYK45_RS36410 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GYK45_RS36425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GYK45_RS36445 ENOG4105VN1 Heat shock protein GYK45_RS36460 ENOG4105C0X amino acid GYK45_RS36510 ENOG4108RCM Nitroreductase GYK45_RS36550 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GYK45_RS36560 ENOG4105CQB FAD linked oxidase domain protein GYK45_RS36595 ENOG4105MXW flavin reductase domain protein, FMN-binding GYK45_RS36600 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS36630 ENOG4105CSH Transporter GYK45_RS36645 ENOG4105MXW flavin reductase domain protein, FMN-binding GYK45_RS36675 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GYK45_RS36685 ENOG4105DJ2 Major Facilitator Superfamily GYK45_RS36690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GYK45_RS36730 ENOG4107RSM transcriptional regulator GYK45_RS36735 ENOG4105DTD Dehydrogenase GYK45_RS36750 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS36765 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GYK45_RS36775 ENOG4105W87 Cbs domain GYK45_RS36790 ENOG4105EYW Ion transport protein GYK45_RS36805 ENOG4108KB2 LysR family Transcriptional regulator GYK45_RS36870 ENOG4107RN3 metallophosphoesterase GYK45_RS36885 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR GYK45_RS36895 ENOG4105D9P serine threonine protein kinase GYK45_RS36915 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GYK45_RS36920 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GYK45_RS36940 ENOG4105EQQ protein containing aminopeptidase domain GYK45_RS36955 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GYK45_RS36985 ENOG4107RRD Dehydrogenase GYK45_RS37015 ENOG4105D3Q Sugar transferase GYK45_RS37020 ENOG4105KVH Transcriptional regulator GYK45_RS37055 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GYK45_RS37060 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS37090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GYK45_RS37105 ENOG4105DXX methyltransferase GYK45_RS37110 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS37115 ENOG4105D5P Methylmalonyl-coA mutase GYK45_RS37185 ENOG4108IAJ Nad-dependent epimerase dehydratase GYK45_RS37200 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GYK45_RS37215 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GYK45_RS37220 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GYK45_RS37230 ENOG4105DKP glycosyl transferase, family 9 GYK45_RS37270 ENOG4105CHR reductase GYK45_RS37275 ENOG4105CSH Transporter GYK45_RS37310 ENOG4108Z6Z Transcriptional regulator GYK45_RS37315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS37325 ENOG4108WUH Transcriptional regulator, TetR family GYK45_RS37330 ENOG4105ETS cytosine purines uracil thiamine allantoin GYK45_RS37365 ENOG4105CHR reductase GYK45_RS37375 ENOG4105R1U AraC Family Transcriptional Regulator GYK45_RS37390 ENOG4105CHR reductase GYK45_RS37495 ENOG4106IPI cyclase, family GYK45_RS37505 ENOG4105CPC Aldo Keto reductase GYK45_RS37510 ENOG4107R37 Glutamate dehydrogenase GYK45_RS37570 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GYK45_RS37575 ENOG4108IND Tetr family transcriptional regulator GYK45_RS37590 ENOG4107RTD sua5 ycio yrdc ywlc family protein GYK45_RS37605 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS37655 ENOG4105EMU Dehydrogenase GYK45_RS37670 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GYK45_RS37735 ENOG4105E2R ROK family GYK45_RS37740 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GYK45_RS37755 ENOG4105CPQ Dehydrogenase GYK45_RS37760 ENOG4107TYA transient receptor potential locus GYK45_RS37780 ENOG4105EE1 crotonyl-CoA reductase GYK45_RS37785 ENOG4108UZX fmn reductase GYK45_RS37795 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GYK45_RS37815 ENOG4105D9P serine threonine protein kinase GYK45_RS37850 ENOG4105CMT Dihydroxyacetone kinase GYK45_RS37890 ENOG4105CHM Aminotransferase GYK45_RS37920 ENOG4105FQP Beta-lactamase GYK45_RS37930 ENOG4106UDK Cellulose-binding, family II GYK45_RS37940 ENOG4105DIA mandelate racemase muconate lactonizing GYK45_RS37945 ENOG41062B0 ABC transporter, permease GYK45_RS37975 ENOG4105CF7 AraC family transcriptional regulator GYK45_RS37980 ENOG4105CHR reductase GYK45_RS37985 ENOG4108VQT Alpha beta hydrolase fold protein GYK45_RS37990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS38020 ENOG4106UDK Cellulose-binding, family II GYK45_RS38035 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GYK45_RS38085 ENOG4105CHR reductase GYK45_RS38130 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS38175 ENOG41061H0 Monooxygenase GYK45_RS38185 ENOG4105BZU Histidine kinase GYK45_RS38190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GYK45_RS38235 ENOG4105CSH Transporter GYK45_RS38260 ENOG4105IKQ hydratase GYK45_RS38270 ENOG4108SGK Tetr family transcriptional regulator GYK45_RS38275 ENOG41069M3 Transcriptional regulator GYK45_RS38280 ENOG4107S5I aldo keto reductase GYK45_RS38330 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS38335 ENOG4108KPJ rna polymerase sigma factor GYK45_RS38345 ENOG4105EHG Permease protein GYK45_RS38365 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GYK45_RS38375 ENOG4105CIR epoxide hydrolase GYK45_RS38400 ENOG4105KME endoribonuclease L-psp GYK45_RS38410 ENOG4108R0M Aminoglycoside GYK45_RS38425 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GYK45_RS38435 ENOG4107RA9 decarboxylase GYK45_RS38455 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS38465 ENOG4105F27 Major Facilitator GYK45_RS38475 ENOG4105CV8 reductase GYK45_RS38490 ENOG4105CNN ABC, transporter GYK45_RS38495 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS38500 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS38520 ENOG4105CMG Carbohydrate kinase GYK45_RS38525 ENOG4108X79 transcriptional regulator GYK45_RS38530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GYK45_RS38535 ENOG4105CPQ Dehydrogenase GYK45_RS38540 ENOG4105CPQ Dehydrogenase GYK45_RS38545 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS38550 ENOG4108R85 Short chain dehydrogenase GYK45_RS38555 ENOG4105CSH Transporter GYK45_RS38560 ENOG4105CPQ Dehydrogenase GYK45_RS38565 ENOG4108HHA Transketolase GYK45_RS38570 ENOG4108IUS Transketolase GYK45_RS38575 ENOG4107258 Transcriptional regulator GYK45_RS38585 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator GYK45_RS38590 ENOG4105CNN ABC, transporter GYK45_RS38595 ENOG4105C2J ABC transporter GYK45_RS38605 ENOG4108UHU Aldolase GYK45_RS38610 ENOG4108R85 Short chain dehydrogenase GYK45_RS38620 ENOG4105CPQ Dehydrogenase GYK45_RS38625 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS38635 ENOG4108Y83 glucose-6-phosphate isomerase GYK45_RS38640 ENOG4108JQ1 Dehydrogenase GYK45_RS38645 ENOG4106KNT transcriptional regulator GYK45_RS38665 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS38675 ENOG4108RU0 short-chain dehydrogenase reductase GYK45_RS38690 ENOG4107MII Sugar-specific transcriptional regulator TrmB GYK45_RS38695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS38705 ENOG4105CIR epoxide hydrolase GYK45_RS38725 ENOG4105CB2 alcohol dehydrogenase GYK45_RS38740 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GYK45_RS38765 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GYK45_RS38790 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GYK45_RS38810 ENOG4105C26 Dehydrogenase GYK45_RS38815 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS38865 ENOG4108ZXC Two component transcriptional regulator, luxr family GYK45_RS38875 ENOG4105C26 Dehydrogenase GYK45_RS38880 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GYK45_RS38930 ENOG4105DRS transport system, permease GYK45_RS38950 ENOG4107HP6 Transcriptional regulator GYK45_RS38960 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GYK45_RS39000 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GYK45_RS39005 ENOG4105MWK D-amino acid dehydrogenase, small subunit GYK45_RS39010 ENOG41080U6 GntR family transcriptional regulator GYK45_RS39015 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) GYK45_RS39025 ENOG4105ERH Fumarylacetoacetate hydrolase GYK45_RS39040 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GYK45_RS39045 ENOG4105C5F glutamine synthetase GYK45_RS39070 ENOG4107QWP ABC-2 type transporter GYK45_RS39075 ENOG4105BZU Histidine kinase GYK45_RS39085 ENOG4108YIQ Alpha beta hydrolase GYK45_RS39095 ENOG4105S7S phosphonate abc transporter GYK45_RS39105 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GYK45_RS39110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GYK45_RS39120 ENOG4105CBG Sulfatase GYK45_RS39125 ENOG4105DEN Luciferase family GYK45_RS39205 ENOG4105E2Y ABC, transporter GYK45_RS39210 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GYK45_RS39250 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GYK45_RS39270 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GYK45_RS39280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS39285 ENOG4105YVS arsR family transcriptional regulator GYK45_RS39290 ENOG4105C2W permease GYK45_RS39320 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase GYK45_RS39345 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GYK45_RS39355 ENOG410829K Lysine exporter protein (Lyse ygga) GYK45_RS39360 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GYK45_RS39405 ENOG4108SGK Tetr family transcriptional regulator GYK45_RS39420 ENOG4105EHG Permease protein GYK45_RS39425 ENOG4105E0A ABC, transporter GYK45_RS39430 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYK45_RS39435 ENOG4105CAQ asparagine synthetase GYK45_RS39470 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GYK45_RS39475 ENOG4105EUB pirin domain protein GYK45_RS39480 ENOG410841Q phosphoesterase PA-phosphatase related protein GYK45_RS39515 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GYK45_RS39530 ENOG4105C5W Aldolase GYK45_RS39535 ENOG4105E9Q Acyl-transferase GYK45_RS39555 ENOG4105C10 Electron transfer flavoprotein GYK45_RS39585 ENOG41060NJ transcriptional regulator GYK45_RS39590 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) GYK45_RS39595 ENOG4108DT4 serine threonine protein kinase GYK45_RS39600 ENOG4105EX0 alpha-galactosidase GYK45_RS39610 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GYK45_RS39615 ENOG4105I1K ABC transporter GYK45_RS39620 ENOG4105I1F Resistance protein GYK45_RS39630 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GYK45_RS39635 ENOG4105BZU Histidine kinase GYK45_RS39640 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS39670 ENOG4105E2R ROK family GYK45_RS39705 ENOG4105MVE transcriptional regulator GYK45_RS39715 ENOG4106F1P AAA ATPase, central domain protein GYK45_RS39780 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GYK45_RS39805 ENOG4105JZI cytochrome P450 GYK45_RS39810 ENOG4105JZI cytochrome P450 GYK45_RS39820 ENOG4105EAH synthase GYK45_RS39825 ENOG4105VDH Dihydroxyacetone kinase GYK45_RS39830 ENOG4108UTZ Dihydroxyacetone kinase GYK45_RS39835 ENOG4105CMT Dihydroxyacetone kinase GYK45_RS39845 ENOG4105X7H acyl-CoA dehydrogenase GYK45_RS39860 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GYK45_RS39870 ENOG4108HMN Caspase domain GYK45_RS39880 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GYK45_RS39940 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS39970 ENOG4108X7A Terpene synthase metal-binding domain-containing protein GYK45_RS40015 ENOG4108MJN Glycosyl Transferase GYK45_RS40035 ENOG4107R7A Allophanate hydrolase subunit 2 GYK45_RS40040 ENOG4105P4J Allophanate hydrolase, subunit 1 GYK45_RS40045 ENOG4105E7W lamb ycsf family protein GYK45_RS40065 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GYK45_RS40100 ENOG4105C26 Dehydrogenase GYK45_RS40105 ENOG4105DVW rieske (2Fe-2S) GYK45_RS40125 ENOG4105VQD rieske 2fe-2S domain-containing protein GYK45_RS40145 ENOG4105GWZ Roadblock lc7 family protein GYK45_RS40160 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS40165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS40170 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GYK45_RS40180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GYK45_RS40185 ENOG4107TYH extracellular solute-binding protein family 1 GYK45_RS40190 ENOG4105D81 ABC transporter, permease GYK45_RS40195 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GYK45_RS40200 ENOG4108UQS dipeptidase GYK45_RS40215 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GYK45_RS40220 ENOG4107SQD Transcriptional regulator, GntR family GYK45_RS40235 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GYK45_RS40285 ENOG4108UW8 fha domain-containing protein GYK45_RS40340 ENOG4105JAB phenazine biosynthesis protein, phzf family GYK45_RS40375 ENOG4105CSW GntR family transcriptional regulator GYK45_RS40380 ENOG4108Q5Y Membrane GYK45_RS40385 ENOG4106P55 Transcriptional regulator GYK45_RS40405 ENOG4105C5H ABC transporter GYK45_RS40415 ENOG4105CBP Major Facilitator GYK45_RS40425 ENOG4105CHR reductase GYK45_RS40430 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS40440 ENOG4105CHP RNA polymerase GYK45_RS40445 ENOG4105GRZ Ycii-related protein GYK45_RS40450 ENOG410836F Transposase GYK45_RS40480 ENOG4108ZHJ Organic hydroperoxide resistance protein GYK45_RS40485 ENOG4108KPJ rna polymerase sigma factor GYK45_RS40545 ENOG41061ZR Transcriptional regulator GYK45_RS40560 ENOG4105CHR reductase GYK45_RS40575 ENOG41061H0 Monooxygenase GYK45_RS40590 ENOG4108QZR synthase GYK45_RS40595 ENOG4105ESN nucleotide-binding protein GYK45_RS40600 ENOG4105JAB phenazine biosynthesis protein, phzf family GYK45_RS40605 ENOG4105C5W Aldolase GYK45_RS40620 ENOG4105F7P transcriptional regulator AsnC family GYK45_RS40635 ENOG4105H3G oxidoreductase GYK45_RS40640 ENOG4105KME endoribonuclease L-psp GYK45_RS40655 ENOG4105CSH Transporter GYK45_RS40660 ENOG4105DUM transcriptional regulator, lysR family GYK45_RS40685 ENOG4105NAE bifunctional deaminase-reductase domain protein GYK45_RS40700 ENOG4105DQE DNA ligase GYK45_RS40730 ENOG41090B9 response to stress GYK45_RS40745 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GYK45_RS40760 ENOG4105CHU acetyl-coa acetyltransferase GYK45_RS40765 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS40775 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GYK45_RS40780 ENOG4105VMP Transcriptional regulator GYK45_RS40795 ENOG41090WU lipolytic protein G-D-S-L family GYK45_RS40800 ENOG4105CQB FAD linked oxidase domain protein GYK45_RS40810 ENOG4105DIA mandelate racemase muconate lactonizing GYK45_RS40865 ENOG4105CHR reductase GYK45_RS40870 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GYK45_RS40880 ENOG4105D29 Helix-turn-helix type 11 domain protein GYK45_RS40930 ENOG4105EP9 oxidoreductase GYK45_RS40935 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GYK45_RS40945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GYK45_RS40950 ENOG41073TP transcriptional regulator GYK45_RS40965 ENOG4108IJ0 Aspartate ammonia-lyase GYK45_RS40980 ENOG4105QCJ Lipoprotein GYK45_RS41015 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS41020 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GYK45_RS41025 ENOG4105KDC 50s ribosomal protein l28 GYK45_RS41035 ENOG4105NRA 50s ribosomal protein l31 type b GYK45_RS41045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GYK45_RS41065 ENOG41066UM arsR family transcriptional regulator GYK45_RS41090 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GYK45_RS41110 ENOG4107RSM transcriptional regulator GYK45_RS41145 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GYK45_RS41220 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GYK45_RS41225 ENOG4105C6Y Udp-glucose 6-dehydrogenase GYK45_RS41240 ENOG4105DTD Dehydrogenase GYK45_RS41255 ENOG4108KGH TRANSCRIPTIONal GYK45_RS41265 ENOG4105ECY inositol monophosphatase GYK45_RS41295 ENOG4105KPV Transcriptional regulator GYK45_RS41365 ENOG4105CHR reductase GYK45_RS41385 ENOG4105BZU Histidine kinase GYK45_RS41390 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS41395 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GYK45_RS41410 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS41415 ENOG4105BZU Histidine kinase GYK45_RS41425 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GYK45_RS41440 ENOG4105CQB FAD linked oxidase domain protein GYK45_RS41445 ENOG4105C1G acyl-Coa dehydrogenase GYK45_RS41455 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GYK45_RS41460 ENOG4108M9J MaoC like domain protein GYK45_RS41475 ENOG4108YYC ycei family GYK45_RS41495 ENOG4105EQX glucarate dehydratase GYK45_RS41505 ENOG4105CDH Citrulline--aspartate ligase GYK45_RS41515 ENOG4105CG3 alpha amylase, catalytic region GYK45_RS41520 ENOG4105I1K ABC transporter GYK45_RS41540 ENOG4105C0B DNA polymerase III (alpha subunit) GYK45_RS41755 ENOG410905P Pyridoxamine 5-phosphate GYK45_RS41770 ENOG4105EQ2 LysR family Transcriptional regulator GYK45_RS41775 ENOG4107AQZ Membrane GYK45_RS41805 ENOG4105VUF Transcriptional regulator GYK45_RS41835 ENOG4105E4I Glycoside hydrolase family 28 GYK45_RS41860 ENOG4105E33 succinate dehydrogenase GYK45_RS41890 ENOG4105CPQ Dehydrogenase GYK45_RS41895 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GYK45_RS41905 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS41910 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GYK45_RS41940 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GYK45_RS41965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GYK45_RS41975 ENOG4106NMR serine protease GYK45_RS42015 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GYK45_RS42030 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GYK45_RS42040 ENOG4105D49 3-dehydroquinate synthase GYK45_RS42045 ENOG4107TXC Transcriptional regulator GYK45_RS42080 ENOG4107QPV Serine Threonine protein kinase GYK45_RS42090 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GYK45_RS42120 ENOG4105EBR Carboxylesterase GYK45_RS42125 ENOG4105CY0 Metallo-Beta-Lactamase GYK45_RS42135 ENOG4105BZU Histidine kinase GYK45_RS42160 ENOG41090U3 tautomerase GYK45_RS42170 ENOG4105D9U N-acetyltransferase GYK45_RS42205 ENOG4105DIA mandelate racemase muconate lactonizing GYK45_RS42260 ENOG4107R34 abc transporter permease protein GYK45_RS42295 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GYK45_RS42300 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS42305 ENOG4107TTA Xylose isomerase domain protein TIM barrel GYK45_RS42310 ENOG4105CK5 oxidoreductase GYK45_RS42315 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GYK45_RS42340 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS42355 ENOG4105E6M Sulphatase-modifying factor protein GYK45_RS42365 ENOG4105DRS transport system, permease GYK45_RS42370 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS42395 ENOG4105CBG Sulfatase GYK45_RS42400 ENOG4107UWC ABC, transporter GYK45_RS42420 ENOG4105E6M Sulphatase-modifying factor protein GYK45_RS42450 ENOG4107QTZ amino acid GYK45_RS42460 ENOG4108QBF Transcriptional regulator GYK45_RS42465 ENOG4105JSC dimethylmenaquinone methyltransferase GYK45_RS42485 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GYK45_RS42510 ENOG4105WH1 Two component transcriptional regulator luxr family GYK45_RS42520 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GYK45_RS42545 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS42560 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS42620 ENOG4108PSK reductase GYK45_RS42665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GYK45_RS42695 ENOG4105C26 Dehydrogenase GYK45_RS42710 ENOG4107S46 esterase, PHB depolymerase GYK45_RS42740 ENOG4105CV8 reductase GYK45_RS42760 ENOG4105C5H ABC transporter GYK45_RS42860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GYK45_RS42865 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GYK45_RS42905 ENOG4105CHF Glutathione S-transferase GYK45_RS42950 ENOG4105DQ4 alcohol dehydrogenase GYK45_RS42960 ENOG4105DDI hemolysin-type calcium-binding region GYK45_RS42970 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 GYK45_RS42985 ENOG4105MKU Transcriptional regulator GYK45_RS43050 ENOG4105EMU Dehydrogenase GYK45_RS43060 ENOG4105WBV Transcriptional regulator GYK45_RS43070 ENOG4105CSH Transporter GYK45_RS43090 ENOG4105E1F short-chain dehydrogenase reductase GYK45_RS43105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GYK45_RS43110 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GYK45_RS43120 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GYK45_RS43125 ENOG4108K8U Glycerol operon regulatory protein GYK45_RS43150 ENOG4105DIA mandelate racemase muconate lactonizing GYK45_RS43155 ENOG4105C6Z Gluconate GYK45_RS43160 ENOG4105EQX glucarate dehydratase GYK45_RS43190 ENOG4106NZI LysR family Transcriptional regulator GYK45_RS43195 ENOG4108JQ1 Dehydrogenase GYK45_RS43200 ENOG4105DTQ mandelate racemase muconate lactonizing GYK45_RS43210 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS43230 ENOG4105CWX Alpha-1,2-mannosidase GYK45_RS43260 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GYK45_RS43275 ENOG4105BZP glycoside hydrolase 15-related GYK45_RS43305 ENOG4105D64 Mechanosensitive ion channel GYK45_RS43330 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS43355 ENOG4105E2B Taurine dioxygenase GYK45_RS43370 ENOG4105C75 arginyL-tRNA synthetase GYK45_RS43375 ENOG4105G9B Transcriptional regulator GYK45_RS43385 ENOG4107QN1 sodium solute GYK45_RS43400 ENOG4106ETB IIa component GYK45_RS43405 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GYK45_RS43410 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GYK45_RS43455 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GYK45_RS43475 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GYK45_RS43520 ENOG4106NMR serine protease GYK45_RS43565 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GYK45_RS43570 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GYK45_RS43575 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GYK45_RS43580 ENOG4105C7W Xanthine dehydrogenase GYK45_RS43615 ENOG4105DEF Extracellular solute-binding protein, family 5 GYK45_RS43645 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS43650 ENOG4108TGC Acyltransferase GYK45_RS43655 ENOG4105CMT Dihydroxyacetone kinase GYK45_RS43660 ENOG4105CMT Dihydroxyacetone kinase GYK45_RS43665 ENOG4105K6H D-cysteine desulfhydrase GYK45_RS43690 ENOG4108JQ1 Dehydrogenase GYK45_RS43700 ENOG4108MRH transcriptional regulatory protein GYK45_RS43715 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GYK45_RS43720 ENOG4105D2X ABC transporter substrate-binding protein GYK45_RS43740 ENOG4108ZJ4 polysaccharide deacetylase GYK45_RS43745 ENOG4105C9Q fumarate hydratase class II GYK45_RS43775 ENOG4105E2B Taurine dioxygenase GYK45_RS43790 ENOG41061H0 Monooxygenase GYK45_RS43795 ENOG4105CJ3 phosphate transporter GYK45_RS43805 ENOG4105DDN Pentapeptide repeat-containing protein GYK45_RS43855 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GYK45_RS43865 ENOG4108IY8 ABC, transporter GYK45_RS43930 ENOG4108U8T Mannosyltransferase GYK45_RS43935 ENOG41090CE integral membrane protein GYK45_RS43970 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GYK45_RS43975 ENOG4108Z40 Transcriptional regulator GYK45_RS44005 ENOG4108K8S endonuclease I GYK45_RS44050 ENOG4105EJ2 Transcriptional regulator GYK45_RS44060 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GYK45_RS44080 ENOG4107SQU synthase GYK45_RS44090 ENOG4105JZI cytochrome P450 GYK45_RS44105 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GYK45_RS44115 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GYK45_RS44120 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GYK45_RS44150 ENOG4105CXN decarboxylase GYK45_RS44180 ENOG4108SIC Transcriptional regulator GYK45_RS44185 ENOG4105EE1 crotonyl-CoA reductase GYK45_RS44195 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GYK45_RS44230 ENOG41081JD Transcriptional regulator GYK45_RS44260 ENOG4105CPC Aldo Keto reductase GYK45_RS44285 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GYK45_RS44290 ENOG4105CSP Major Facilitator Superfamily GYK45_RS44295 ENOG4105FB2 class II Aldolase GYK45_RS44300 ENOG4105G63 Type III effector Hrp-dependent GYK45_RS44305 ENOG4105ZXK Dehydrogenase GYK45_RS44315 ENOG4105C5I Dehydrogenase GYK45_RS44395 ENOG4105KVH Transcriptional regulator GYK45_RS44425 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GYK45_RS44445 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS44480 ENOG4105C0W non-ribosomal peptide synthetase GYK45_RS44490 ENOG4105CIH Imidazole acetol-phosphate transaminase GYK45_RS44505 ENOG4105KNA -acetyltransferase GYK45_RS44540 ENOG4105PAD Hydrolase GYK45_RS44565 ENOG4108PVU Nucleotidyl transferase GYK45_RS44570 ENOG4108KK4 3-dehydroquinate synthase GYK45_RS44580 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GYK45_RS44605 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GYK45_RS44625 ENOG4105BZP glycoside hydrolase 15-related GYK45_RS44665 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GYK45_RS44675 ENOG4108S01 response regulator GYK45_RS44690 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GYK45_RS44695 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GYK45_RS44710 ENOG4106A3M Cytochrome p-450 GYK45_RS44725 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GYK45_RS44750 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GYK45_RS44765 ENOG4105EMU Dehydrogenase GYK45_RS44835 ENOG4108KPJ rna polymerase sigma factor GYK45_RS44860 ENOG4108Z4U Ferredoxin GYK45_RS44870 ENOG4108KPJ rna polymerase sigma factor GYK45_RS44945 ENOG4107SVN transposase GYK45_RS45010 ENOG4107SVN transposase GYK45_RS45025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GYK45_RS45030 ENOG4105DBE peroxidase GYK45_RS45060 ENOG4105ECQ AraC Family Transcriptional Regulator GYK45_RS45075 ENOG4108JGH Tetr family transcriptional regulator GYK45_RS45090 ENOG4105ETE Transcriptional regulator (LacI family GYK45_RS45095 ENOG4105C2J ABC transporter GYK45_RS45100 ENOG4105CNN ABC, transporter GYK45_RS45105 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator GYK45_RS45120 ENOG4108HKT sucrose-6-phosphate hydrolase GYK45_RS45180 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GYK45_RS45195 ENOG41073TP transcriptional regulator GYK45_RS45205 ENOG4105C0R drug resistance transporter emrb qaca subfamily GYK45_RS45215 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GYK45_RS45315 ENOG4105R0I Feruloyl esterase GYK45_RS45350 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GYK45_RS45395 ENOG41080XS Cobyrinic acid ac-diamide synthase GYK45_RS45420 ENOG4108PJD permease GYK45_RS45430 ENOG4105C1J atp-dependent rna helicase GYK45_RS45530 ENOG410834F Transcriptional regulator GYK45_RS45600 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GYK45_RS45610 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GYK45_RS45615 ENOG4105CI2 imidazolone-5-propionate hydrolase GYK45_RS45660 ENOG4105FD8 phosphonate metabolism protein PhnM GYK45_RS45665 ENOG4105CDA abc transporter atp-binding protein GYK45_RS45670 ENOG4105ENV phosphonate C-P lyase system protein PhnK GYK45_RS45690 ENOG4105ENX hydrolase GYK45_RS45705 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GYK45_RS45710 ENOG4105CY0 Metallo-Beta-Lactamase GYK45_RS45725 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GYK45_RS45745 ENOG41073TP transcriptional regulator GYK45_RS45765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS45770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS45780 ENOG4108JQ7 (ABC) transporter GYK45_RS45790 ENOG4105CHR reductase GYK45_RS45795 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GYK45_RS45805 ENOG41073TP transcriptional regulator GYK45_RS45810 ENOG4105CTB Polyprenyl synthetase GYK45_RS45815 ENOG4105FDK ABC transporter GYK45_RS45830 ENOG4105CS1 NAD(P)H quinone oxidoreductase GYK45_RS45835 ENOG4107RA9 decarboxylase GYK45_RS45840 ENOG4105CD3 dihydroorotase GYK45_RS45860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GYK45_RS45885 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GYK45_RS45900 ENOG4105KME endoribonuclease L-psp GYK45_RS45905 ENOG4105KVH Transcriptional regulator GYK45_RS45915 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GYK45_RS45970 ENOG4107S1E Beta-lactamase GYK45_RS45985 ENOG4105DTQ mandelate racemase muconate lactonizing GYK45_RS46000 ENOG4108JQ7 (ABC) transporter GYK45_RS46010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GYK45_RS46015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GYK45_RS46020 ENOG4105DEF Extracellular solute-binding protein, family 5 GYK45_RS46025 ENOG4105PDP Short chain dehydrogenase GYK45_RS46035 ENOG4107YPT transcriptional regulator GYK45_RS46050 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GYK45_RS46130 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) GYK45_RS46145 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GYK45_RS46150 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GYK45_RS46190 ENOG4105CSP Major Facilitator Superfamily GYK45_RS46195 ENOG41090HR transcriptional regulator GYK45_RS46200 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GYK45_RS46205 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS46215 ENOG4105E39 Enoyl-CoA hydratase GYK45_RS46220 ENOG4105CEY Amp-dependent synthetase and ligase GYK45_RS46225 ENOG4105EA8 2-Nitropropane dioxygenase GYK45_RS46235 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GYK45_RS46285 ENOG4108WUH Transcriptional regulator, TetR family GYK45_RS46345 ENOG4105C54 Major Facilitator superfamily GYK45_RS46370 ENOG4108UAU isochorismatase GYK45_RS46415 ENOG4105C0A alcohol dehydrogenase GYK45_RS46430 ENOG4105E8R UPF0173 metal-dependent hydrolase GYK45_RS46455 ENOG4105E8R UPF0173 metal-dependent hydrolase GYK45_RS46470 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GYK45_RS46475 ENOG4107ZXU DSBA oxidoreductase GYK45_RS46480 ENOG4105KVH Transcriptional regulator GYK45_RS46495 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GYK45_RS46515 ENOG4105DTD Dehydrogenase GYK45_RS46545 ENOG4105CHR reductase GYK45_RS46640 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GYK45_RS46655 ENOG4105C7W Xanthine dehydrogenase GYK45_RS46660 ENOG4105C7W Xanthine dehydrogenase GYK45_RS46670 ENOG4105CPC Aldo Keto reductase GYK45_RS46715 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GYK45_RS46720 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GYK45_RS46735 ENOG4105KI2 Urea amidohydrolase subunit beta GYK45_RS46745 ENOG4105DRS transport system, permease GYK45_RS46750 ENOG4108URH decarboxylase GYK45_RS46760 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GYK45_RS46765 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS46785 ENOG4108KP7 hydrolase GYK45_RS46790 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GYK45_RS46835 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GYK45_RS46905 ENOG4105MP0 transposase