locus-tag	class	description
GYK45_RS00010	COG3896	Chloramphenicol phosphotransferase-like protein
GYK45_RS00055	COG1957	nucleoside hydrolase
GYK45_RS00095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS00160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYK45_RS00170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS00175	COG1091	dTDP-4-dehydrorhamnose reductase activity
GYK45_RS00180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GYK45_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS00195	COG2089	acid synthase
GYK45_RS00205	COG1132	(ABC) transporter
GYK45_RS00210	COG1132	(ABC) transporter
GYK45_RS00215	COG1132	(ABC) transporter
GYK45_RS00275	COG0174	glutamine synthetase
GYK45_RS00280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GYK45_RS00285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYK45_RS00365	COG3629	intracellular signal transduction
GYK45_RS00365	COG3903	Transcriptional regulator
GYK45_RS00405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS00465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYK45_RS00470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYK45_RS00475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYK45_RS00620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS00735	COG3835	regulator
GYK45_RS00745	COG1408	metallophosphoesterase
GYK45_RS00750	COG2197	response regulator
GYK45_RS00755	COG4585	Histidine kinase
GYK45_RS00760	COG2409	Drug exporters of the RND superfamily
GYK45_RS00920	COG4977	sequence-specific DNA binding
GYK45_RS00930	COG0596	Alpha beta hydrolase
GYK45_RS00975	COG3629	intracellular signal transduction
GYK45_RS00975	COG3903	Transcriptional regulator
GYK45_RS00980	COG1132	(ABC) transporter
GYK45_RS00985	COG1132	(ABC) transporter
GYK45_RS00995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS01015	COG1132	(ABC) transporter
GYK45_RS01050	COG0402	S-adenosylhomocysteine deaminase activity
GYK45_RS01060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYK45_RS01065	COG0351	phosphomethylpyrimidine kinase
GYK45_RS01075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GYK45_RS01130	COG0726	polysaccharide deacetylase
GYK45_RS01195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GYK45_RS01210	COG1982	Orn Lys Arg decarboxylase major
GYK45_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS01280	COG0583	DNA-binding transcription factor activity
GYK45_RS01300	COG1846	Transcriptional regulator
GYK45_RS01330	COG0798	PFAM Bile acid sodium symporter
GYK45_RS01345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GYK45_RS01360	COG1846	Transcriptional regulator
GYK45_RS01375	COG2353	YceI-like domain
GYK45_RS01395	COG3655	Transcriptional regulator
GYK45_RS01435	COG3573	Dehydrogenase
GYK45_RS01440	COG0129	dihydroxy-acid dehydratase activity
GYK45_RS01445	COG2271	Major facilitator Superfamily
GYK45_RS01455	COG0066	3-isopropylmalate dehydratase activity
GYK45_RS01460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GYK45_RS01470	COG0066	3-isopropylmalate dehydratase activity
GYK45_RS01475	COG2423	ornithine cyclodeaminase activity
GYK45_RS01485	COG0006	proline dipeptidase activity
GYK45_RS01490	COG2271	Major facilitator Superfamily
GYK45_RS01505	COG2197	response regulator
GYK45_RS01530	COG1175	transmembrane transport
GYK45_RS01545	COG1609	Transcriptional regulator
GYK45_RS01590	COG0776	regulation of translation
GYK45_RS01655	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS01660	COG1309	transcriptional regulator
GYK45_RS01690	COG1129	ABC transporter
GYK45_RS01700	COG1069	ribulokinase activity
GYK45_RS01710	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GYK45_RS01715	COG0395	ABC-type sugar transport system, permease component
GYK45_RS01720	COG1175	transmembrane transport
GYK45_RS01825	COG0395	ABC-type sugar transport system, permease component
GYK45_RS01835	COG3547	Transposase (IS116 IS110 IS902 family)
GYK45_RS01860	COG0583	DNA-binding transcription factor activity
GYK45_RS01905	COG0434	BtpA family
GYK45_RS01920	COG1129	ABC transporter
GYK45_RS01925	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS01955	COG0730	response to heat
GYK45_RS01970	COG1396	sequence-specific DNA binding
GYK45_RS02010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS02020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS02030	COG0179	Fumarylacetoacetate (FAA) hydrolase
GYK45_RS02035	COG1802	Transcriptional regulator
GYK45_RS02130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS02180	COG1609	Transcriptional regulator
GYK45_RS02190	COG1175	transmembrane transport
GYK45_RS02195	COG0395	ABC-type sugar transport system, permease component
GYK45_RS02200	COG1940	carbohydrate kinase activity
GYK45_RS02205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GYK45_RS02280	COG0667	Aldo Keto reductase
GYK45_RS02285	COG1309	transcriptional regulator
GYK45_RS02290	COG1733	regulation of RNA biosynthetic process
GYK45_RS02360	COG3693	PFAM glycoside hydrolase, family 10
GYK45_RS02390	COG3345	alpha-galactosidase
GYK45_RS02395	COG3507	Belongs to the glycosyl hydrolase 43 family
GYK45_RS02460	COG0667	Aldo Keto reductase
GYK45_RS02475	COG0583	DNA-binding transcription factor activity
GYK45_RS02515	COG4585	Histidine kinase
GYK45_RS02535	COG0655	NAD(P)H dehydrogenase (quinone) activity
GYK45_RS02690	COG0667	Aldo Keto reductase
GYK45_RS02705	COG1252	NADH dehydrogenase
GYK45_RS02720	COG1595	DNA-templated transcription, initiation
GYK45_RS02725	COG0604	alcohol dehydrogenase
GYK45_RS02745	COG0166	Belongs to the GPI family
GYK45_RS02750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GYK45_RS02755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GYK45_RS02780	COG1609	Transcriptional regulator
GYK45_RS02795	COG0765	amino acid transport
GYK45_RS02825	COG0778	Nitroreductase
GYK45_RS02830	COG1064	alcohol dehydrogenase
GYK45_RS02840	COG2315	Protein conserved in bacteria
GYK45_RS02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GYK45_RS02860	COG2770	Histidine kinase
GYK45_RS02860	COG2208	phosphoserine phosphatase activity
GYK45_RS02880	COG2159	amidohydrolase
GYK45_RS02885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GYK45_RS02900	COG0698	ribose 5-phosphate isomerase
GYK45_RS02910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GYK45_RS02930	COG0588	phosphoglycerate mutase activity
GYK45_RS02955	COG1178	ABC-type Fe3 transport system permease component
GYK45_RS02960	COG3842	ATPase activity
GYK45_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GYK45_RS02985	COG2186	Transcriptional regulator
GYK45_RS03010	COG4989	oxidoreductase activity
GYK45_RS03030	COG1053	succinate dehydrogenase
GYK45_RS03035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYK45_RS03050	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GYK45_RS03060	COG0596	Alpha beta hydrolase
GYK45_RS03090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03185	COG0183	Belongs to the thiolase family
GYK45_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03200	COG1024	Enoyl-CoA hydratase
GYK45_RS03205	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS03210	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03295	COG1132	(ABC) transporter
GYK45_RS03310	COG0604	alcohol dehydrogenase
GYK45_RS03325	COG1486	melibiose metabolic process
GYK45_RS03335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYK45_RS03345	COG1175	transmembrane transport
GYK45_RS03350	COG0395	ABC-type sugar transport system, permease component
GYK45_RS03355	COG3250	beta-galactosidase activity
GYK45_RS03420	COG0745	RESPONSE REGULATOR receiver
GYK45_RS03430	COG0431	NADPH-dependent FMN reductase
GYK45_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS03445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS03460	COG3458	cephalosporin-C deacetylase activity
GYK45_RS03485	COG1233	COG1233 Phytoene dehydrogenase and related
GYK45_RS03545	COG2382	esterase
GYK45_RS03550	COG1132	(ABC) transporter
GYK45_RS03560	COG1132	(ABC) transporter
GYK45_RS03565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GYK45_RS03570	COG1120	ATPase activity
GYK45_RS03575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS03585	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GYK45_RS03600	COG1609	Transcriptional regulator
GYK45_RS03615	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS03620	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS03625	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GYK45_RS03630	COG1691	(AIR) carboxylase
GYK45_RS03635	COG1606	tRNA processing
GYK45_RS03645	COG0477	Major facilitator Superfamily
GYK45_RS03745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS03760	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS03765	COG1465	3-dehydroquinate synthase
GYK45_RS03770	COG1830	Aldolase
GYK45_RS03785	COG0583	DNA-binding transcription factor activity
GYK45_RS03795	COG0745	RESPONSE REGULATOR receiver
GYK45_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS03860	COG0601	transmembrane transport
GYK45_RS03875	COG1940	carbohydrate kinase activity
GYK45_RS03880	COG3119	arylsulfatase activity
GYK45_RS03910	COG1840	ABC-type Fe3 transport system, periplasmic component
GYK45_RS03915	COG3842	ATPase activity
GYK45_RS03920	COG1176	ABC-type spermidine putrescine transport system, permease component I
GYK45_RS03935	COG2755	lipolytic protein G-D-S-L family
GYK45_RS03935	COG3401	FG-GAP repeat protein
GYK45_RS03945	COG3345	alpha-galactosidase
GYK45_RS03950	COG3547	Transposase (IS116 IS110 IS902 family)
GYK45_RS03965	COG0583	DNA-binding transcription factor activity
GYK45_RS03990	COG0477	Major facilitator Superfamily
GYK45_RS04045	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
GYK45_RS04055	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS04065	COG1454	alcohol dehydrogenase
GYK45_RS04080	COG2814	Major facilitator Superfamily
GYK45_RS04095	COG0697	spore germination
GYK45_RS04130	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS04145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GYK45_RS04145	COG1796	DNA polymerase
GYK45_RS04160	COG0673	inositol 2-dehydrogenase activity
GYK45_RS04175	COG2814	Major facilitator Superfamily
GYK45_RS04200	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS04205	COG0667	Aldo Keto reductase
GYK45_RS04225	COG0667	Aldo Keto reductase
GYK45_RS04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GYK45_RS04270	COG0765	amino acid transport
GYK45_RS04290	COG3458	cephalosporin-C deacetylase activity
GYK45_RS04305	COG0501	Belongs to the peptidase M48B family
GYK45_RS04335	COG1309	transcriptional regulator
GYK45_RS04360	COG4770	biotin carboxylase activity
GYK45_RS04370	COG3173	Aminoglycoside phosphotransferase
GYK45_RS04375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS04400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS04405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GYK45_RS04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GYK45_RS04455	COG1132	(ABC) transporter
GYK45_RS04460	COG1132	(ABC) transporter
GYK45_RS04490	COG1414	Transcriptional regulator
GYK45_RS04500	COG3485	protocatechuate 3,4-dioxygenase
GYK45_RS04555	COG1309	transcriptional regulator
GYK45_RS04590	COG1113	amino acid transport
GYK45_RS04605	COG0477	Major facilitator Superfamily
GYK45_RS04620	COG3395	kinase activity
GYK45_RS04625	COG0235	Class ii aldolase
GYK45_RS04640	COG3622	Belongs to the hyi family
GYK45_RS04670	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS04695	COG0300	oxidoreductase activity
GYK45_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS04710	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS04715	COG2814	Major facilitator Superfamily
GYK45_RS04730	COG0145	ligase activity
GYK45_RS04755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS04775	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS04780	COG1309	transcriptional regulator
GYK45_RS04785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GYK45_RS04790	COG0586	Pfam SNARE associated Golgi protein
GYK45_RS04800	COG2197	response regulator
GYK45_RS04835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GYK45_RS04865	COG1280	lysine exporter protein (LysE YggA)
GYK45_RS04880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GYK45_RS04915	COG3384	dioxygenase
GYK45_RS04935	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GYK45_RS04940	COG0492	ferredoxin-NADP+ reductase activity
GYK45_RS04955	COG1940	carbohydrate kinase activity
GYK45_RS04955	COG1846	Transcriptional regulator
GYK45_RS04975	COG0515	serine threonine protein kinase
GYK45_RS04975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GYK45_RS04995	COG0367	asparagine synthase
GYK45_RS05030	COG4221	oxidoreductase activity
GYK45_RS05050	COG1397	ADP-ribosylglycohydrolase
GYK45_RS05055	COG2188	Transcriptional regulator
GYK45_RS05065	COG2267	carboxylic ester hydrolase activity
GYK45_RS05090	COG1733	regulation of RNA biosynthetic process
GYK45_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS05105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYK45_RS05110	COG4166	transmembrane transport
GYK45_RS05115	COG0601	transmembrane transport
GYK45_RS05130	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS05150	COG1609	Transcriptional regulator
GYK45_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS05165	COG0673	inositol 2-dehydrogenase activity
GYK45_RS05180	COG2080	2 iron, 2 sulfur cluster binding
GYK45_RS05185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GYK45_RS05210	COG3708	Transcriptional regulator
GYK45_RS05210	COG2207	Transcriptional regulator
GYK45_RS05215	COG1113	amino acid transport
GYK45_RS05220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYK45_RS05240	COG2318	DinB family
GYK45_RS05270	COG1733	regulation of RNA biosynthetic process
GYK45_RS05280	COG1309	transcriptional regulator
GYK45_RS05290	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS05295	COG3321	synthase
GYK45_RS05295	COG0604	alcohol dehydrogenase
GYK45_RS05380	COG1132	(ABC) transporter
GYK45_RS05395	COG1132	(ABC) transporter
GYK45_RS05400	COG1132	(ABC) transporter
GYK45_RS05415	COG1946	Acyl-CoA thioesterase
GYK45_RS05425	COG2018	Roadblock/LC7 domain
GYK45_RS05470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GYK45_RS05475	COG4279	zinc finger
GYK45_RS05480	COG4677	pectinesterase activity
GYK45_RS05490	COG1070	Carbohydrate kinase
GYK45_RS05495	COG1940	carbohydrate kinase activity
GYK45_RS05510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS05515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS05530	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS05535	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS05545	COG3572	ergothioneine biosynthetic process
GYK45_RS05550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYK45_RS05560	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GYK45_RS05570	COG3573	Dehydrogenase
GYK45_RS05580	COG4667	esterase of the alpha-beta hydrolase superfamily
GYK45_RS05630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS05640	COG0531	amino acid
GYK45_RS05655	COG2340	Cysteine-rich secretory protein family
GYK45_RS05710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS05765	COG0243	molybdopterin cofactor binding
GYK45_RS05765	COG3383	formate dehydrogenase (NAD+) activity
GYK45_RS05770	COG0437	4 iron, 4 sulfur cluster binding
GYK45_RS05825	COG0789	Transcriptional regulator
GYK45_RS05940	COG0246	Mannitol dehydrogenase
GYK45_RS05945	COG2271	Major facilitator Superfamily
GYK45_RS05950	COG1063	alcohol dehydrogenase
GYK45_RS05955	COG3012	SEC-C Motif Domain Protein
GYK45_RS05970	COG0006	proline dipeptidase activity
GYK45_RS05990	COG0477	Major facilitator Superfamily
GYK45_RS06005	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GYK45_RS06040	COG1301	dicarboxylic acid transport
GYK45_RS06045	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS06060	COG1414	Transcriptional regulator
GYK45_RS06080	COG0604	alcohol dehydrogenase
GYK45_RS06085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS06110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GYK45_RS06125	COG2080	2 iron, 2 sulfur cluster binding
GYK45_RS06130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GYK45_RS06135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS06140	COG1309	transcriptional regulator
GYK45_RS06160	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS06305	COG2945	thiolester hydrolase activity
GYK45_RS06305	COG0596	Alpha beta hydrolase
GYK45_RS06355	COG2936	dipeptidyl-peptidase activity
GYK45_RS06370	COG0542	response to heat
GYK45_RS06380	COG1595	DNA-templated transcription, initiation
GYK45_RS06390	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS06400	COG0747	negative chemotaxis
GYK45_RS06430	COG0384	phenazine biosynthesis protein PhzF
GYK45_RS06435	COG2313	pseudouridylate synthase activity
GYK45_RS06440	COG1522	sequence-specific DNA binding
GYK45_RS06440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYK45_RS06445	COG0189	ligase activity
GYK45_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS06480	COG2207	Transcriptional regulator
GYK45_RS06490	COG3290	protein histidine kinase activity
GYK45_RS06500	COG0673	inositol 2-dehydrogenase activity
GYK45_RS06515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS06525	COG1834	amidinotransferase
GYK45_RS06530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYK45_RS06535	COG3224	Antibiotic biosynthesis monooxygenase
GYK45_RS06555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS06565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS06585	COG0477	Major facilitator Superfamily
GYK45_RS06590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GYK45_RS06605	COG0443	Heat shock 70 kDa protein
GYK45_RS06625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GYK45_RS06635	COG1522	sequence-specific DNA binding
GYK45_RS06650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS06655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS06670	COG0596	Alpha beta hydrolase
GYK45_RS06675	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS06680	COG1802	Transcriptional regulator
GYK45_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS06735	COG3250	beta-galactosidase activity
GYK45_RS06745	COG1796	DNA polymerase
GYK45_RS06745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GYK45_RS06770	COG2723	6-phospho-beta-galactosidase activity
GYK45_RS06775	COG0395	ABC-type sugar transport system, permease component
GYK45_RS06780	COG1175	transmembrane transport
GYK45_RS06790	COG1940	carbohydrate kinase activity
GYK45_RS06815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GYK45_RS06820	COG1349	DNA-binding transcription factor activity
GYK45_RS06825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GYK45_RS06870	COG0745	RESPONSE REGULATOR receiver
GYK45_RS06875	COG2205	protein histidine kinase activity
GYK45_RS06880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYK45_RS06890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GYK45_RS06905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GYK45_RS06945	COG0183	Belongs to the thiolase family
GYK45_RS06950	COG1309	transcriptional regulator
GYK45_RS06970	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS06975	COG1024	Enoyl-CoA hydratase
GYK45_RS07015	COG3360	Dodecin
GYK45_RS07030	COG3959	Transketolase, thiamine diphosphate binding domain
GYK45_RS07065	COG0667	Aldo Keto reductase
GYK45_RS07075	COG2197	response regulator
GYK45_RS07080	COG3851	Histidine kinase
GYK45_RS07140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GYK45_RS07235	COG0110	maltose O-acetyltransferase activity
GYK45_RS07295	COG0671	phosphoesterase, PA-phosphatase related
GYK45_RS07310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GYK45_RS07315	COG1733	regulation of RNA biosynthetic process
GYK45_RS07320	COG0477	Major facilitator Superfamily
GYK45_RS07350	COG0745	RESPONSE REGULATOR receiver
GYK45_RS07355	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS07375	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GYK45_RS07380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GYK45_RS07400	COG2133	pyrroloquinoline quinone binding
GYK45_RS07420	COG0174	glutamine synthetase
GYK45_RS07430	COG4221	oxidoreductase activity
GYK45_RS07435	COG3537	Alpha-1,2-mannosidase
GYK45_RS07440	COG1064	alcohol dehydrogenase
GYK45_RS07450	COG2851	Citrate transporter
GYK45_RS07455	COG0583	DNA-binding transcription factor activity
GYK45_RS07460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GYK45_RS07485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GYK45_RS07490	COG1595	DNA-templated transcription, initiation
GYK45_RS07500	COG0386	Belongs to the glutathione peroxidase family
GYK45_RS07595	COG1175	transmembrane transport
GYK45_RS07600	COG1653	transport
GYK45_RS07605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYK45_RS07615	COG1486	melibiose metabolic process
GYK45_RS07640	COG1063	alcohol dehydrogenase
GYK45_RS07675	COG0514	ATP-dependent DNA helicase (RecQ)
GYK45_RS07700	COG2186	Transcriptional regulator
GYK45_RS07835	COG0277	FAD linked oxidase domain protein
GYK45_RS07840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GYK45_RS07865	COG1063	alcohol dehydrogenase
GYK45_RS07915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS07935	COG0242	peptide deformylase activity
GYK45_RS07980	COG0395	ABC-type sugar transport system, permease component
GYK45_RS08005	COG3903	Transcriptional regulator
GYK45_RS08005	COG3629	intracellular signal transduction
GYK45_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS08075	COG0667	Aldo Keto reductase
GYK45_RS08080	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS08095	COG0601	transmembrane transport
GYK45_RS08100	COG0747	negative chemotaxis
GYK45_RS08105	COG3395	kinase activity
GYK45_RS08115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GYK45_RS08120	COG1349	DNA-binding transcription factor activity
GYK45_RS08125	COG1132	(ABC) transporter
GYK45_RS08130	COG1132	(ABC) transporter
GYK45_RS08155	COG1793	dna ligase
GYK45_RS08170	COG0252	asparaginase activity
GYK45_RS08185	COG1309	transcriptional regulator
GYK45_RS08190	COG3631	Ketosteroid isomerase-related protein
GYK45_RS08195	COG0702	epimerase
GYK45_RS08240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GYK45_RS08255	COG0242	peptide deformylase activity
GYK45_RS08265	COG3442	glutamine amidotransferase
GYK45_RS08270	COG0205	6-phosphofructokinase activity
GYK45_RS08315	COG0829	nickel cation binding
GYK45_RS08325	COG0830	nickel cation binding
GYK45_RS08335	COG0832	Belongs to the urease beta subunit family
GYK45_RS08345	COG4935	Belongs to the peptidase S8 family
GYK45_RS08345	COG2234	aminopeptidase activity
GYK45_RS08355	COG0740	serine-type endopeptidase activity
GYK45_RS08365	COG0741	lytic transglycosylase activity
GYK45_RS08365	COG0791	NLP P60 protein
GYK45_RS08390	COG0156	8-amino-7-oxononanoate synthase activity
GYK45_RS08395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GYK45_RS08400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GYK45_RS08405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GYK45_RS08410	COG2226	methyltransferase
GYK45_RS08415	COG1136	(ABC) transporter
GYK45_RS08415	COG0577	efflux transmembrane transporter activity
GYK45_RS08470	COG1940	carbohydrate kinase activity
GYK45_RS08475	COG2188	Transcriptional regulator
GYK45_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS08485	COG2267	carboxylic ester hydrolase activity
GYK45_RS08525	COG0420	3'-5' exonuclease activity
GYK45_RS08530	COG1739	Uncharacterized protein family UPF0029
GYK45_RS08545	COG4585	Histidine kinase
GYK45_RS08560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GYK45_RS08570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GYK45_RS08605	COG3336	cytochrome c oxidase
GYK45_RS08650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GYK45_RS08660	COG2814	Major facilitator Superfamily
GYK45_RS08665	COG1968	undecaprenyl-diphosphatase activity
GYK45_RS08675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS08735	COG0583	DNA-binding transcription factor activity
GYK45_RS08745	COG1309	transcriptional regulator
GYK45_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS08780	COG1309	transcriptional regulator
GYK45_RS08790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYK45_RS08795	COG1522	sequence-specific DNA binding
GYK45_RS08800	COG4977	sequence-specific DNA binding
GYK45_RS08820	COG0640	Transcriptional regulator
GYK45_RS08845	COG2267	carboxylic ester hydrolase activity
GYK45_RS08855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GYK45_RS08870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYK45_RS08900	COG0183	Belongs to the thiolase family
GYK45_RS08905	COG1024	Enoyl-CoA hydratase
GYK45_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS08935	COG0183	Belongs to the thiolase family
GYK45_RS08945	COG1024	Enoyl-CoA hydratase
GYK45_RS08950	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS08970	COG0477	Major facilitator Superfamily
GYK45_RS08975	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS08990	COG3976	FMN-binding domain protein
GYK45_RS08990	COG1053	succinate dehydrogenase
GYK45_RS08995	COG1070	Carbohydrate kinase
GYK45_RS09015	COG3290	protein histidine kinase activity
GYK45_RS09020	COG4565	transcriptional regulatory protein
GYK45_RS09025	COG1609	Transcriptional regulator
GYK45_RS09030	COG0698	ribose 5-phosphate isomerase
GYK45_RS09090	COG0583	DNA-binding transcription factor activity
GYK45_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYK45_RS09105	COG0395	ABC-type sugar transport system, permease component
GYK45_RS09130	COG2018	Roadblock/LC7 domain
GYK45_RS09135	COG0642	Histidine kinase
GYK45_RS09150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYK45_RS09225	COG3321	synthase
GYK45_RS09225	COG0604	alcohol dehydrogenase
GYK45_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS09245	COG2409	Drug exporters of the RND superfamily
GYK45_RS09260	COG0667	Aldo Keto reductase
GYK45_RS09275	COG1064	alcohol dehydrogenase
GYK45_RS09325	COG0154	amidase activity
GYK45_RS09340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS09360	COG1874	Beta-galactosidase
GYK45_RS09370	COG0395	ABC-type sugar transport system, permease component
GYK45_RS09375	COG1175	transmembrane transport
GYK45_RS09410	COG0477	Major facilitator Superfamily
GYK45_RS09420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYK45_RS09425	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GYK45_RS09435	COG0596	Alpha beta hydrolase
GYK45_RS09450	COG3903	Transcriptional regulator
GYK45_RS09450	COG3629	intracellular signal transduction
GYK45_RS09495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS09520	COG1609	Transcriptional regulator
GYK45_RS09525	COG2814	Major facilitator Superfamily
GYK45_RS09530	COG0589	response to stress
GYK45_RS09535	COG1609	Transcriptional regulator
GYK45_RS09565	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS09570	COG1129	ABC transporter
GYK45_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS09585	COG3347	Dehydrogenase
GYK45_RS09590	COG1070	Carbohydrate kinase
GYK45_RS09595	COG0247	lactate metabolic process
GYK45_RS09620	COG1940	carbohydrate kinase activity
GYK45_RS09640	COG0154	amidase activity
GYK45_RS09670	COG1940	carbohydrate kinase activity
GYK45_RS09690	COG2186	Transcriptional regulator
GYK45_RS09695	COG2364	Membrane
GYK45_RS09720	COG2111	Na H antiporter
GYK45_RS09725	COG1006	Multisubunit Na H antiporter MnhC subunit
GYK45_RS09730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS09740	COG0463	Glycosyl transferase, family 2
GYK45_RS09790	COG1621	beta-fructofuranosidase activity
GYK45_RS09805	COG1609	Transcriptional regulator
GYK45_RS09820	COG3833	ABC-type maltose transport systems, permease component
GYK45_RS09825	COG1175	transmembrane transport
GYK45_RS09830	COG1653	transport
GYK45_RS09845	COG0667	Aldo Keto reductase
GYK45_RS09855	COG4166	transmembrane transport
GYK45_RS09860	COG0601	transmembrane transport
GYK45_RS09870	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS09875	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS09890	COG2132	Multicopper oxidase
GYK45_RS09955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS09970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS09975	COG2124	cytochrome p450
GYK45_RS09990	COG2175	clavaminate synthase activity
GYK45_RS10045	COG3835	regulator
GYK45_RS10115	COG2315	Protein conserved in bacteria
GYK45_RS10120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS10170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS10180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS10185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GYK45_RS10205	COG0673	inositol 2-dehydrogenase activity
GYK45_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS10270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GYK45_RS10275	COG0140	phosphoribosyl-ATP diphosphatase activity
GYK45_RS10280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GYK45_RS10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GYK45_RS10285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GYK45_RS10305	COG1940	carbohydrate kinase activity
GYK45_RS10305	COG1846	Transcriptional regulator
GYK45_RS10310	COG0738	Major facilitator superfamily
GYK45_RS10320	COG2233	PERMEase
GYK45_RS10345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYK45_RS10355	COG0531	amino acid
GYK45_RS10375	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS10380	COG1620	l-lactate permease
GYK45_RS10400	COG1414	Transcriptional regulator
GYK45_RS10415	COG2390	Transcriptional regulator
GYK45_RS10420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GYK45_RS10435	COG1132	(ABC) transporter
GYK45_RS10440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GYK45_RS10455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GYK45_RS10470	COG0194	GDP metabolic process
GYK45_RS10480	COG0284	orotidine-5'-phosphate decarboxylase activity
GYK45_RS10485	COG0167	dihydroorotate dehydrogenase activity
GYK45_RS10490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GYK45_RS10495	COG0505	Belongs to the CarA family
GYK45_RS10505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYK45_RS10510	COG0540	Belongs to the ATCase OTCase family
GYK45_RS10515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GYK45_RS10525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GYK45_RS10530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GYK45_RS10535	COG0006	proline dipeptidase activity
GYK45_RS10545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GYK45_RS10550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GYK45_RS10555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GYK45_RS10560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GYK45_RS10570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GYK45_RS10590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GYK45_RS10610	COG1131	(ABC) transporter
GYK45_RS10620	COG4585	Histidine kinase
GYK45_RS10625	COG2197	response regulator
GYK45_RS10630	COG0124	histidyl-tRNA synthetase
GYK45_RS10640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GYK45_RS10645	COG1196	nuclear chromosome segregation
GYK45_RS10650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GYK45_RS10655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GYK45_RS10660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GYK45_RS10665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GYK45_RS10680	COG0632	four-way junction helicase activity
GYK45_RS10685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GYK45_RS10690	COG0217	transcriptional regulatory protein
GYK45_RS10700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GYK45_RS10710	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS10715	COG1560	Kdo2-lipid A biosynthetic process
GYK45_RS10740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GYK45_RS10755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GYK45_RS10785	COG0395	ABC-type sugar transport system, permease component
GYK45_RS10790	COG1175	transmembrane transport
GYK45_RS10840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GYK45_RS10840	COG0512	Glutamine amidotransferase of anthranilate synthase
GYK45_RS10885	COG1309	transcriptional regulator
GYK45_RS10890	COG1733	regulation of RNA biosynthetic process
GYK45_RS10895	COG2814	Major facilitator Superfamily
GYK45_RS10920	COG1648	precorrin-2 dehydrogenase activity
GYK45_RS10920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GYK45_RS10925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GYK45_RS10940	COG1464	Belongs to the NlpA lipoprotein family
GYK45_RS10945	COG2011	ABC-type metal ion transport system permease component
GYK45_RS10950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GYK45_RS10985	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS10985	COG0204	Acyl-transferase
GYK45_RS11005	COG0137	argininosuccinate synthase activity
GYK45_RS11040	COG1477	protein flavinylation
GYK45_RS11060	COG1438	arginine binding
GYK45_RS11065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYK45_RS11070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GYK45_RS11075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GYK45_RS11080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GYK45_RS11130	COG0697	spore germination
GYK45_RS11140	COG1649	PFAM Uncharacterised BCR, COG1649
GYK45_RS11165	COG1285	pathogenesis
GYK45_RS11190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GYK45_RS11190	COG0072	phenylalanine-tRNA ligase activity
GYK45_RS11195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GYK45_RS11200	COG5002	protein histidine kinase activity
GYK45_RS11205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GYK45_RS11210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GYK45_RS11215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GYK45_RS11220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GYK45_RS11235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GYK45_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS11295	COG0531	amino acid
GYK45_RS11300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GYK45_RS11380	COG2755	lipolytic protein G-D-S-L family
GYK45_RS11405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYK45_RS11410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GYK45_RS11425	COG1657	PFAM Prenyltransferase squalene oxidase
GYK45_RS11435	COG1233	COG1233 Phytoene dehydrogenase and related
GYK45_RS11460	COG2124	cytochrome p450
GYK45_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS11490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GYK45_RS11520	COG1134	teichoic acid transport
GYK45_RS11565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GYK45_RS11575	COG1024	Enoyl-CoA hydratase
GYK45_RS11585	COG2183	response to ionizing radiation
GYK45_RS11595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GYK45_RS11605	COG2936	dipeptidyl-peptidase activity
GYK45_RS11620	COG3250	beta-galactosidase activity
GYK45_RS11625	COG0789	Transcriptional regulator
GYK45_RS11635	COG0583	DNA-binding transcription factor activity
GYK45_RS11640	COG1024	Enoyl-CoA hydratase
GYK45_RS11640	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS11645	COG0183	Belongs to the thiolase family
GYK45_RS11660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS11670	COG1515	deoxyribonuclease V activity
GYK45_RS11725	COG0531	amino acid
GYK45_RS11770	COG0431	NADPH-dependent FMN reductase
GYK45_RS11780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS11810	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS11875	COG1309	transcriptional regulator
GYK45_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS11930	COG0519	Catalyzes the synthesis of GMP from XMP
GYK45_RS11935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GYK45_RS11940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GYK45_RS11950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GYK45_RS11960	COG1733	regulation of RNA biosynthetic process
GYK45_RS11965	COG0702	epimerase
GYK45_RS11975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYK45_RS11980	COG0667	Aldo Keto reductase
GYK45_RS11990	COG1609	Transcriptional regulator
GYK45_RS11995	COG0583	DNA-binding transcription factor activity
GYK45_RS12000	COG0697	spore germination
GYK45_RS12010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GYK45_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS12025	COG0519	Catalyzes the synthesis of GMP from XMP
GYK45_RS12030	COG0789	Transcriptional regulator
GYK45_RS12035	COG2226	methyltransferase
GYK45_RS12035	COG1073	alpha beta
GYK45_RS12055	COG2890	protein-(glutamine-N5) methyltransferase activity
GYK45_RS12065	COG0248	Ppx GppA phosphatase
GYK45_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS12105	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS12145	COG0210	DNA helicase
GYK45_RS12155	COG1401	restriction endodeoxyribonuclease activity
GYK45_RS12200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GYK45_RS12210	COG0515	serine threonine protein kinase
GYK45_RS12210	COG2815	serine threonine protein kinase
GYK45_RS12305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GYK45_RS12310	COG0667	Aldo Keto reductase
GYK45_RS12315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GYK45_RS12405	COG0045	succinate-CoA ligase (ADP-forming) activity
GYK45_RS12415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GYK45_RS12420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GYK45_RS12420	COG1042	CoA-binding domain protein
GYK45_RS12420	COG0045	succinate-CoA ligase (ADP-forming) activity
GYK45_RS12485	COG0673	inositol 2-dehydrogenase activity
GYK45_RS12490	COG1879	ABC-type sugar transport system periplasmic component
GYK45_RS12495	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS12500	COG1129	ABC transporter
GYK45_RS12505	COG1940	carbohydrate kinase activity
GYK45_RS12525	COG3383	formate dehydrogenase (NAD+) activity
GYK45_RS12540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GYK45_RS12545	COG1309	transcriptional regulator
GYK45_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS12580	COG2226	methyltransferase
GYK45_RS12610	COG0656	L-ascorbic acid biosynthetic process
GYK45_RS12620	COG1595	DNA-templated transcription, initiation
GYK45_RS12635	COG2154	pterin-4-alpha-carbinolamine dehydratase
GYK45_RS12675	COG0531	amino acid
GYK45_RS12685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GYK45_RS12690	COG3842	ATPase activity
GYK45_RS12710	COG4213	ABC transporter substrate-binding protein
GYK45_RS12770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GYK45_RS12805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS12810	COG2867	negative regulation of translational initiation
GYK45_RS12865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS12870	COG0028	Belongs to the TPP enzyme family
GYK45_RS12875	COG0693	protein deglycase activity
GYK45_RS12905	COG0516	GMP reductase activity
GYK45_RS12905	COG0517	IMP dehydrogenase activity
GYK45_RS12910	COG4106	trans-aconitate 2-methyltransferase activity
GYK45_RS12945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GYK45_RS12950	COG2362	D-Aminopeptidase
GYK45_RS12990	COG1309	transcriptional regulator
GYK45_RS12995	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS13015	COG2301	Belongs to the HpcH HpaI aldolase family
GYK45_RS13025	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS13030	COG0688	phosphatidylethanolamine metabolic process
GYK45_RS13040	COG1929	Belongs to the glycerate kinase type-1 family
GYK45_RS13065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GYK45_RS13100	COG0181	hydroxymethylbilane synthase activity
GYK45_RS13110	COG0483	inositol monophosphate 1-phosphatase activity
GYK45_RS13135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYK45_RS13140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYK45_RS13160	COG0477	Major facilitator Superfamily
GYK45_RS13170	COG0405	Gamma-glutamyltransferase
GYK45_RS13205	COG0765	amino acid transport
GYK45_RS13210	COG0765	amino acid transport
GYK45_RS13215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GYK45_RS13220	COG1126	abc transporter atp-binding protein
GYK45_RS13245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS13255	COG1940	carbohydrate kinase activity
GYK45_RS13295	COG0800	Aldolase
GYK45_RS13370	COG4266	Belongs to the allantoicase family
GYK45_RS13375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYK45_RS13380	COG1414	Transcriptional regulator
GYK45_RS13390	COG0746	molybdenum cofactor guanylyltransferase activity
GYK45_RS13415	COG2351	hydroxyisourate hydrolase activity
GYK45_RS13450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS13455	COG2197	response regulator
GYK45_RS13460	COG0598	Magnesium transport protein CorA
GYK45_RS13485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS13500	COG3835	regulator
GYK45_RS13510	COG1802	Transcriptional regulator
GYK45_RS13560	COG0028	Belongs to the TPP enzyme family
GYK45_RS13570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GYK45_RS13580	COG1162	GTPase activity
GYK45_RS13605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GYK45_RS13615	COG0175	sulfate reduction
GYK45_RS13620	COG0529	Catalyzes the synthesis of activated sulfate
GYK45_RS13635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GYK45_RS13640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GYK45_RS13645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS13705	COG2409	Drug exporters of the RND superfamily
GYK45_RS13710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GYK45_RS13730	COG1175	transmembrane transport
GYK45_RS13750	COG2188	Transcriptional regulator
GYK45_RS13755	COG1119	ATPase activity
GYK45_RS13800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYK45_RS13855	COG5002	protein histidine kinase activity
GYK45_RS13860	COG0745	RESPONSE REGULATOR receiver
GYK45_RS13905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYK45_RS13910	COG3220	belongs to the UPF0276 family
GYK45_RS13940	COG1414	Transcriptional regulator
GYK45_RS13955	COG2271	Major facilitator Superfamily
GYK45_RS13960	COG0446	pyridine nucleotide-disulphide oxidoreductase
GYK45_RS13970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GYK45_RS13985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GYK45_RS13995	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS13995	COG1024	Enoyl-CoA hydratase
GYK45_RS14010	COG0531	amino acid
GYK45_RS14015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYK45_RS14020	COG4214	carbohydrate transport
GYK45_RS14030	COG4213	ABC transporter substrate-binding protein
GYK45_RS14035	COG1940	carbohydrate kinase activity
GYK45_RS14045	COG1175	transmembrane transport
GYK45_RS14065	COG1335	isochorismatase
GYK45_RS14070	COG1733	regulation of RNA biosynthetic process
GYK45_RS14095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GYK45_RS14115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GYK45_RS14120	COG0583	DNA-binding transcription factor activity
GYK45_RS14135	COG1309	transcriptional regulator
GYK45_RS14170	COG3345	alpha-galactosidase
GYK45_RS14180	COG1175	transmembrane transport
GYK45_RS14185	COG0395	ABC-type sugar transport system, permease component
GYK45_RS14185	COG0395	ABC-type sugar transport system, permease component
GYK45_RS14200	COG2186	Transcriptional regulator
GYK45_RS14205	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS14215	COG0800	Aldolase
GYK45_RS14220	COG3386	PFAM SMP-30 Gluconolaconase
GYK45_RS14240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GYK45_RS14270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GYK45_RS14310	COG2409	Drug exporters of the RND superfamily
GYK45_RS14335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GYK45_RS14340	COG0531	amino acid
GYK45_RS14375	COG0569	domain protein
GYK45_RS14440	COG2205	protein histidine kinase activity
GYK45_RS14445	COG0745	RESPONSE REGULATOR receiver
GYK45_RS14490	COG1435	thymidine kinase activity
GYK45_RS14505	COG0045	succinate-CoA ligase (ADP-forming) activity
GYK45_RS14505	COG1042	CoA-binding domain protein
GYK45_RS14505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GYK45_RS14510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GYK45_RS14515	COG1802	Transcriptional regulator
GYK45_RS14530	COG0612	Peptidase, M16
GYK45_RS14550	COG3290	protein histidine kinase activity
GYK45_RS14560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYK45_RS14585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GYK45_RS14590	COG1802	Transcriptional regulator
GYK45_RS14625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GYK45_RS14655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GYK45_RS14660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GYK45_RS14695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GYK45_RS14705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GYK45_RS14710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GYK45_RS14720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GYK45_RS14735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYK45_RS14740	COG1414	Transcriptional regulator
GYK45_RS14765	COG1126	abc transporter atp-binding protein
GYK45_RS14770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GYK45_RS14775	COG0765	amino acid transport
GYK45_RS14780	COG0765	amino acid transport
GYK45_RS14795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GYK45_RS14845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GYK45_RS14860	COG1396	sequence-specific DNA binding
GYK45_RS14865	COG1546	Belongs to the CinA family
GYK45_RS14865	COG1058	Belongs to the CinA family
GYK45_RS14875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GYK45_RS14885	COG1674	ftsk spoiiie
GYK45_RS14895	COG2208	phosphoserine phosphatase activity
GYK45_RS14895	COG2770	Histidine kinase
GYK45_RS14925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GYK45_RS14930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS14935	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GYK45_RS14955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GYK45_RS14960	COG0612	Peptidase, M16
GYK45_RS14965	COG1185	polyribonucleotide nucleotidyltransferase activity
GYK45_RS14970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GYK45_RS15080	COG1404	Belongs to the peptidase S8 family
GYK45_RS15110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GYK45_RS15115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GYK45_RS15125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GYK45_RS15140	COG0779	Required for maturation of 30S ribosomal subunits
GYK45_RS15160	COG0442	prolyl-tRNA aminoacylation
GYK45_RS15175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GYK45_RS15180	COG0750	zinc metalloprotease
GYK45_RS15185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GYK45_RS15210	COG0395	ABC-type sugar transport system, permease component
GYK45_RS15215	COG4209	transmembrane transport
GYK45_RS15230	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS15235	COG2508	Transcriptional regulator
GYK45_RS15255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYK45_RS15260	COG1177	transmembrane transport
GYK45_RS15265	COG1176	ABC-type spermidine putrescine transport system, permease component I
GYK45_RS15270	COG3842	ATPase activity
GYK45_RS15295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GYK45_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS15335	COG0028	Belongs to the TPP enzyme family
GYK45_RS15340	COG1136	(ABC) transporter
GYK45_RS15355	COG3842	ATPase activity
GYK45_RS15370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GYK45_RS15375	COG0575	Belongs to the CDS family
GYK45_RS15380	COG0233	cytoplasmic translational termination
GYK45_RS15385	COG0528	UMP kinase activity
GYK45_RS15390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GYK45_RS15395	COG0052	Belongs to the universal ribosomal protein uS2 family
GYK45_RS15410	COG1191	sigma factor activity
GYK45_RS15450	COG0792	nuclease activity
GYK45_RS15460	COG1051	belongs to the nudix hydrolase family
GYK45_RS15465	COG0681	Belongs to the peptidase S26 family
GYK45_RS15470	COG0681	Belongs to the peptidase S26 family
GYK45_RS15480	COG0681	Belongs to the peptidase S26 family
GYK45_RS15485	COG0335	large ribosomal subunit rRNA binding
GYK45_RS15490	COG0336	Belongs to the RNA methyltransferase TrmD family
GYK45_RS15500	COG1837	Belongs to the UPF0109 family
GYK45_RS15505	COG0228	four-way junction DNA binding
GYK45_RS15515	COG0442	prolyl-tRNA aminoacylation
GYK45_RS15585	COG0477	Major facilitator Superfamily
GYK45_RS15600	COG1254	Belongs to the acylphosphatase family
GYK45_RS15610	COG1733	regulation of RNA biosynthetic process
GYK45_RS15615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GYK45_RS15620	COG0571	ribonuclease III activity
GYK45_RS15625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GYK45_RS15640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GYK45_RS15645	COG0742	ribosomal rna small subunit methyltransferase
GYK45_RS15655	COG1461	Dihydroxyacetone kinase
GYK45_RS15660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GYK45_RS15665	COG0351	phosphomethylpyrimidine kinase
GYK45_RS15690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GYK45_RS15705	COG0776	regulation of translation
GYK45_RS15715	COG0066	3-isopropylmalate dehydratase activity
GYK45_RS15725	COG1414	Transcriptional regulator
GYK45_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GYK45_RS15770	COG0179	Fumarylacetoacetate (FAA) hydrolase
GYK45_RS15780	COG5002	protein histidine kinase activity
GYK45_RS15785	COG2018	Roadblock/LC7 domain
GYK45_RS15805	COG2018	Roadblock/LC7 domain
GYK45_RS15825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYK45_RS15830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYK45_RS15835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GYK45_RS15840	COG0473	3-isopropylmalate dehydrogenase activity
GYK45_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS15855	COG0506	proline dehydrogenase activity
GYK45_RS15870	COG0477	Major facilitator Superfamily
GYK45_RS15905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GYK45_RS15910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GYK45_RS15915	COG0440	acetolactate synthase activity
GYK45_RS15935	COG0667	Aldo Keto reductase
GYK45_RS15945	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GYK45_RS15945	COG1672	PFAM Archaeal ATPase
GYK45_RS15955	COG2409	Drug exporters of the RND superfamily
GYK45_RS15975	COG0154	amidase activity
GYK45_RS15980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GYK45_RS15990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GYK45_RS16000	COG0300	oxidoreductase activity
GYK45_RS16010	COG1819	glycosyl
GYK45_RS16025	COG0482	sulfurtransferase activity
GYK45_RS16050	COG0596	Alpha beta hydrolase
GYK45_RS16065	COG2860	membrane
GYK45_RS16070	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS16075	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS16085	COG4166	transmembrane transport
GYK45_RS16115	COG0509	glycine decarboxylation via glycine cleavage system
GYK45_RS16120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GYK45_RS16125	COG1760	l-serine dehydratase
GYK45_RS16140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GYK45_RS16170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GYK45_RS16190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GYK45_RS16270	COG1132	(ABC) transporter
GYK45_RS16275	COG1132	(ABC) transporter
GYK45_RS16315	COG3340	Belongs to the peptidase S51 family
GYK45_RS16320	COG2318	DinB family
GYK45_RS16340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GYK45_RS16355	COG3401	FG-GAP repeat protein
GYK45_RS16375	COG0366	Alpha amylase catalytic
GYK45_RS16385	COG3281	Trehalose synthase
GYK45_RS16390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GYK45_RS16410	COG3290	protein histidine kinase activity
GYK45_RS16415	COG4565	transcriptional regulatory protein
GYK45_RS16425	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYK45_RS16425	COG0567	Dehydrogenase, E1 component
GYK45_RS16430	COG4977	sequence-specific DNA binding
GYK45_RS16435	COG3469	chitinase activity
GYK45_RS16485	COG1309	transcriptional regulator
GYK45_RS16505	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS16510	COG1316	TRANSCRIPTIONal
GYK45_RS16515	COG3833	ABC-type maltose transport systems, permease component
GYK45_RS16545	COG0205	6-phosphofructokinase activity
GYK45_RS16550	COG0280	phosphate acetyltransferase
GYK45_RS16550	COG0857	belongs to the CobB CobQ family
GYK45_RS16555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GYK45_RS16650	COG0745	RESPONSE REGULATOR receiver
GYK45_RS16715	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GYK45_RS16730	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS16760	COG4585	Histidine kinase
GYK45_RS16765	COG2197	response regulator
GYK45_RS16775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GYK45_RS16780	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GYK45_RS16785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GYK45_RS16790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GYK45_RS16795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GYK45_RS16800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GYK45_RS16805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GYK45_RS16825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GYK45_RS16830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GYK45_RS16840	COG2890	protein-(glutamine-N5) methyltransferase activity
GYK45_RS16845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GYK45_RS16850	COG0254	rRNA binding
GYK45_RS16855	COG1316	TRANSCRIPTIONal
GYK45_RS16870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GYK45_RS16875	COG0460	homoserine dehydrogenase
GYK45_RS16880	COG0019	diaminopimelate decarboxylase activity
GYK45_RS16885	COG0018	arginyl-trna synthetase
GYK45_RS16885	COG0018	arginyl-trna synthetase
GYK45_RS16890	COG0745	RESPONSE REGULATOR receiver
GYK45_RS16900	COG3903	Transcriptional regulator
GYK45_RS16900	COG3629	intracellular signal transduction
GYK45_RS16950	COG3903	Transcriptional regulator
GYK45_RS16950	COG3629	intracellular signal transduction
GYK45_RS16970	COG0477	Major facilitator Superfamily
GYK45_RS16985	COG0583	DNA-binding transcription factor activity
GYK45_RS17020	COG1388	LysM domain
GYK45_RS17020	COG3103	Sh3 type 3 domain protein
GYK45_RS17020	COG0791	NLP P60 protein
GYK45_RS17070	COG2249	NAD(P)H dehydrogenase (quinone) activity
GYK45_RS17075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GYK45_RS17090	COG0745	RESPONSE REGULATOR receiver
GYK45_RS17095	COG2205	protein histidine kinase activity
GYK45_RS17100	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYK45_RS17100	COG0567	Dehydrogenase, E1 component
GYK45_RS17110	COG0789	Transcriptional regulator
GYK45_RS17135	COG0778	Nitroreductase
GYK45_RS17150	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS17150	COG3321	synthase
GYK45_RS17150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS17150	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS17150	COG0300	oxidoreductase activity
GYK45_RS17175	COG0281	malic enzyme
GYK45_RS17185	COG0765	amino acid transport
GYK45_RS17235	COG0583	DNA-binding transcription factor activity
GYK45_RS17265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GYK45_RS17285	COG2066	Belongs to the glutaminase family
GYK45_RS17325	COG1597	lipid kinase activity
GYK45_RS17340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GYK45_RS17345	COG1472	Belongs to the glycosyl hydrolase 3 family
GYK45_RS17355	COG1175	transmembrane transport
GYK45_RS17405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS17410	COG4221	oxidoreductase activity
GYK45_RS17440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GYK45_RS17460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GYK45_RS17460	COG2199	diguanylate cyclase activity
GYK45_RS17465	COG5662	AntiSigma factor
GYK45_RS17470	COG1595	DNA-templated transcription, initiation
GYK45_RS17480	COG2135	peptidase activity
GYK45_RS17490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GYK45_RS17500	COG2076	Multidrug Resistance protein
GYK45_RS17510	COG0483	inositol monophosphate 1-phosphatase activity
GYK45_RS17520	COG0753	catalase activity
GYK45_RS17545	COG1615	UPF0182 protein
GYK45_RS17555	COG3480	Lon protease (S16) C-terminal proteolytic domain
GYK45_RS17640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GYK45_RS17740	COG0596	Alpha beta hydrolase
GYK45_RS17745	COG1432	Conserved Protein
GYK45_RS17750	COG2095	MarC family integral membrane protein
GYK45_RS17770	COG0598	Magnesium transport protein CorA
GYK45_RS17810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GYK45_RS17825	COG1595	DNA-templated transcription, initiation
GYK45_RS17840	COG1024	Enoyl-CoA hydratase
GYK45_RS17845	COG0519	Catalyzes the synthesis of GMP from XMP
GYK45_RS17855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GYK45_RS17860	COG1611	Belongs to the LOG family
GYK45_RS17865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GYK45_RS17900	COG2197	response regulator
GYK45_RS17905	COG4585	Histidine kinase
GYK45_RS17915	COG1131	(ABC) transporter
GYK45_RS17935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GYK45_RS17955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GYK45_RS17960	COG0747	negative chemotaxis
GYK45_RS17970	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS17975	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS17990	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS18005	COG0601	transmembrane transport
GYK45_RS18010	COG4166	transmembrane transport
GYK45_RS18040	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS18045	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS18050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GYK45_RS18055	COG0601	transmembrane transport
GYK45_RS18085	COG1053	succinate dehydrogenase
GYK45_RS18110	COG0531	amino acid
GYK45_RS18130	COG4115	mRNA cleavage
GYK45_RS18135	COG2161	toxin-antitoxin pair type II binding
GYK45_RS18140	COG0583	DNA-binding transcription factor activity
GYK45_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS18155	COG2814	Major facilitator Superfamily
GYK45_RS18175	COG4221	oxidoreductase activity
GYK45_RS18180	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GYK45_RS18220	COG0012	GTP binding
GYK45_RS18235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GYK45_RS18240	COG1570	exodeoxyribonuclease VII activity
GYK45_RS18275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GYK45_RS18275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GYK45_RS18280	COG3469	chitinase activity
GYK45_RS18295	COG0114	fumarate hydratase activity
GYK45_RS18315	COG1309	transcriptional regulator
GYK45_RS18320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GYK45_RS18335	COG3409	Peptidoglycan-binding domain 1 protein
GYK45_RS18365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYK45_RS18385	COG1136	(ABC) transporter
GYK45_RS18400	COG0450	alkyl hydroperoxide reductase
GYK45_RS18405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS18420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GYK45_RS18425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GYK45_RS18440	COG1278	Cold shock
GYK45_RS18445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GYK45_RS18450	COG2885	chlorophyll binding
GYK45_RS18550	COG2610	gluconate transmembrane transporter activity
GYK45_RS18560	COG1414	Transcriptional regulator
GYK45_RS18575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GYK45_RS18605	COG0601	transmembrane transport
GYK45_RS18640	COG1272	protein, Hemolysin III
GYK45_RS18650	COG1331	Highly conserved protein containing a thioredoxin domain
GYK45_RS18670	COG0583	DNA-binding transcription factor activity
GYK45_RS18675	COG3629	intracellular signal transduction
GYK45_RS18675	COG3903	Transcriptional regulator
GYK45_RS18695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GYK45_RS18740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYK45_RS18785	COG2770	Histidine kinase
GYK45_RS18785	COG2208	phosphoserine phosphatase activity
GYK45_RS18820	COG2304	oxidoreductase activity
GYK45_RS18850	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS18860	COG0583	DNA-binding transcription factor activity
GYK45_RS18885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS18930	COG2018	Roadblock/LC7 domain
GYK45_RS18935	COG5002	protein histidine kinase activity
GYK45_RS18950	COG0583	DNA-binding transcription factor activity
GYK45_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS18970	COG0583	DNA-binding transcription factor activity
GYK45_RS19000	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS19005	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS19105	COG0667	Aldo Keto reductase
GYK45_RS19110	COG0577	efflux transmembrane transporter activity
GYK45_RS19110	COG1136	(ABC) transporter
GYK45_RS19115	COG1136	(ABC) transporter
GYK45_RS19120	COG2814	Major facilitator Superfamily
GYK45_RS19155	COG4585	Histidine kinase
GYK45_RS19170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GYK45_RS19175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GYK45_RS19180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GYK45_RS19185	COG0193	aminoacyl-tRNA hydrolase activity
GYK45_RS19195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GYK45_RS19205	COG1309	transcriptional regulator
GYK45_RS19225	COG4106	trans-aconitate 2-methyltransferase activity
GYK45_RS19235	COG2197	response regulator
GYK45_RS19240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GYK45_RS19275	COG0488	(ABC) transporter
GYK45_RS19280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GYK45_RS19285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GYK45_RS19290	COG3584	3D domain protein
GYK45_RS19290	COG3583	domain protein
GYK45_RS19295	COG0084	hydrolase, TatD family'
GYK45_RS19385	COG1122	ATPase activity
GYK45_RS19395	COG0310	cobalt ion transport
GYK45_RS19400	COG2409	Drug exporters of the RND superfamily
GYK45_RS19425	COG2267	carboxylic ester hydrolase activity
GYK45_RS19430	COG2072	flavoprotein involved in K transport
GYK45_RS19440	COG0708	Exodeoxyribonuclease III
GYK45_RS19455	COG0783	Belongs to the Dps family
GYK45_RS19470	COG0640	Transcriptional regulator
GYK45_RS19515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GYK45_RS19525	COG0315	cyclic pyranopterin monophosphate synthase activity
GYK45_RS19535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GYK45_RS19540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GYK45_RS19550	COG3263	regulation of cellular component size
GYK45_RS19560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GYK45_RS19570	COG1970	mechanosensitive ion channel activity
GYK45_RS19580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS19590	COG3634	alkyl hydroperoxide reductase activity
GYK45_RS19600	COG1105	Belongs to the carbohydrate kinase PfkB family
GYK45_RS19605	COG1349	DNA-binding transcription factor activity
GYK45_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS19630	COG3384	dioxygenase
GYK45_RS19635	COG1846	Transcriptional regulator
GYK45_RS19655	COG1309	transcriptional regulator
GYK45_RS19695	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GYK45_RS19740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GYK45_RS19810	COG0515	serine threonine protein kinase
GYK45_RS19815	COG1309	transcriptional regulator
GYK45_RS19820	COG3246	L-lysine catabolic process to acetate
GYK45_RS19825	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS19830	COG0824	Thioesterase
GYK45_RS19830	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS19845	COG0640	Transcriptional regulator
GYK45_RS19850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GYK45_RS19855	COG1793	dna ligase
GYK45_RS19865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GYK45_RS19875	COG1309	transcriptional regulator
GYK45_RS19925	COG1653	transport
GYK45_RS19935	COG1686	Belongs to the peptidase S11 family
GYK45_RS19960	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS19990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GYK45_RS20010	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS20015	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GYK45_RS20075	COG1024	Enoyl-CoA hydratase
GYK45_RS20090	COG0515	serine threonine protein kinase
GYK45_RS20090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GYK45_RS20100	COG1309	transcriptional regulator
GYK45_RS20110	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS20145	COG1024	Enoyl-CoA hydratase
GYK45_RS20150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS20160	COG4977	sequence-specific DNA binding
GYK45_RS20185	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS20200	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS20205	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS20210	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS20230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GYK45_RS20245	COG1077	Cell shape determining protein MreB Mrl
GYK45_RS20260	COG0516	GMP reductase activity
GYK45_RS20270	COG1595	DNA-templated transcription, initiation
GYK45_RS20285	COG0583	DNA-binding transcription factor activity
GYK45_RS20295	COG4221	oxidoreductase activity
GYK45_RS20300	COG0459	protein refolding
GYK45_RS20305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GYK45_RS20310	COG0726	polysaccharide deacetylase
GYK45_RS20360	COG2205	protein histidine kinase activity
GYK45_RS20365	COG0745	RESPONSE REGULATOR receiver
GYK45_RS20380	COG1136	(ABC) transporter
GYK45_RS20380	COG0577	efflux transmembrane transporter activity
GYK45_RS20385	COG0577	efflux transmembrane transporter activity
GYK45_RS20385	COG1136	(ABC) transporter
GYK45_RS20390	COG0596	Alpha beta hydrolase
GYK45_RS20395	COG3903	Transcriptional regulator
GYK45_RS20395	COG3629	intracellular signal transduction
GYK45_RS20405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GYK45_RS20430	COG0802	atpase or kinase
GYK45_RS20435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYK45_RS20440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GYK45_RS20470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GYK45_RS20480	COG1072	(Pantothenic acid kinase))
GYK45_RS20490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GYK45_RS20500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GYK45_RS20515	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS20525	COG2770	Histidine kinase
GYK45_RS20525	COG2208	phosphoserine phosphatase activity
GYK45_RS20535	COG2172	sigma factor antagonist activity
GYK45_RS20540	COG1366	Belongs to the anti-sigma-factor antagonist family
GYK45_RS20545	COG1366	Belongs to the anti-sigma-factor antagonist family
GYK45_RS20550	COG0101	tRNA pseudouridine synthase activity
GYK45_RS20555	COG0203	ribosomal protein L17
GYK45_RS20560	COG0202	RNA polymerase activity
GYK45_RS20570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GYK45_RS20575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GYK45_RS20580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GYK45_RS20585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GYK45_RS20605	COG0200	Binds to the 23S rRNA
GYK45_RS20615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GYK45_RS20620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GYK45_RS20630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GYK45_RS20640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GYK45_RS20645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GYK45_RS20650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GYK45_RS20655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GYK45_RS20660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GYK45_RS20665	COG0255	Belongs to the universal ribosomal protein uL29 family
GYK45_RS20670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GYK45_RS20675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GYK45_RS20680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GYK45_RS20685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GYK45_RS20690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GYK45_RS20695	COG0089	rRNA binding
GYK45_RS20700	COG0088	Forms part of the polypeptide exit tunnel
GYK45_RS20705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GYK45_RS20710	COG0051	transcription antitermination factor activity, RNA binding
GYK45_RS20735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GYK45_RS20740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GYK45_RS20750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GYK45_RS20775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GYK45_RS20785	COG0222	ribosome binding
GYK45_RS20790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GYK45_RS20800	COG0081	regulation of translation
GYK45_RS20805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GYK45_RS20825	COG0436	Aminotransferase
GYK45_RS20830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GYK45_RS20835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GYK45_RS20845	COG2030	dehydratase
GYK45_RS20850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GYK45_RS20870	COG0702	epimerase
GYK45_RS20890	COG1970	mechanosensitive ion channel activity
GYK45_RS20905	COG1666	GTP binding
GYK45_RS20915	COG0501	Belongs to the peptidase M48B family
GYK45_RS20940	COG0839	Belongs to the complex I subunit 6 family
GYK45_RS20945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS20950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GYK45_RS20955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS20965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS20970	COG4585	Histidine kinase
GYK45_RS20975	COG4585	Histidine kinase
GYK45_RS20985	COG0674	pyruvate-flavodoxin oxidoreductase activity
GYK45_RS20985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GYK45_RS20990	COG1013	pyruvate-flavodoxin oxidoreductase activity
GYK45_RS20995	COG0531	amino acid
GYK45_RS21000	COG0702	epimerase
GYK45_RS21060	COG1007	ATP synthesis coupled electron transport
GYK45_RS21070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GYK45_RS21075	COG0713	ATP synthesis coupled electron transport
GYK45_RS21090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GYK45_RS21100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GYK45_RS21115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS21120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GYK45_RS21130	COG1388	LysM domain
GYK45_RS21130	COG3103	Sh3 type 3 domain protein
GYK45_RS21130	COG0791	NLP P60 protein
GYK45_RS21150	COG2226	methyltransferase
GYK45_RS21160	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GYK45_RS21175	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GYK45_RS21200	COG1309	transcriptional regulator
GYK45_RS21210	COG2076	Multidrug Resistance protein
GYK45_RS21215	COG1301	dicarboxylic acid transport
GYK45_RS21230	COG1573	uracil-dna glycosylase
GYK45_RS21235	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GYK45_RS21245	COG0163	prenyltransferase activity
GYK45_RS21250	COG0109	protoheme IX farnesyltransferase activity
GYK45_RS21255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GYK45_RS21265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GYK45_RS21270	COG1333	cytochrome c biogenesis protein
GYK45_RS21275	COG0785	Cytochrome C biogenesis protein
GYK45_RS21290	COG0406	alpha-ribazole phosphatase activity
GYK45_RS21295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GYK45_RS21310	COG1742	UPF0060 membrane protein
GYK45_RS21340	COG1690	Belongs to the RtcB family
GYK45_RS21360	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GYK45_RS21365	COG0018	arginyl-trna synthetase
GYK45_RS21385	COG1072	(Pantothenic acid kinase))
GYK45_RS21390	COG0113	porphobilinogen synthase activity
GYK45_RS21395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GYK45_RS21395	COG1648	precorrin-2 dehydrogenase activity
GYK45_RS21400	COG0181	hydroxymethylbilane synthase activity
GYK45_RS21405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GYK45_RS21410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GYK45_RS21420	COG0560	Phosphoserine phosphatase
GYK45_RS21470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS21490	COG0180	Tryptophanyl-tRNA synthetase
GYK45_RS21495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GYK45_RS21525	COG0129	dihydroxy-acid dehydratase activity
GYK45_RS21530	COG1309	transcriptional regulator
GYK45_RS21535	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS21540	COG0248	Ppx GppA phosphatase
GYK45_RS21560	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GYK45_RS21580	COG1695	Transcriptional regulator
GYK45_RS21600	COG1194	a g-specific adenine glycosylase
GYK45_RS21605	COG1595	DNA-templated transcription, initiation
GYK45_RS21615	COG0745	RESPONSE REGULATOR receiver
GYK45_RS21620	COG2205	protein histidine kinase activity
GYK45_RS21625	COG0346	lactoylglutathione lyase activity
GYK45_RS21645	COG0739	heme binding
GYK45_RS21670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GYK45_RS21680	COG0724	RNA recognition motif
GYK45_RS21690	COG2205	protein histidine kinase activity
GYK45_RS21695	COG0745	RESPONSE REGULATOR receiver
GYK45_RS21710	COG1136	(ABC) transporter
GYK45_RS21740	COG1609	Transcriptional regulator
GYK45_RS21745	COG0745	RESPONSE REGULATOR receiver
GYK45_RS21780	COG2897	thiosulfate sulfurtransferase activity
GYK45_RS21800	COG3485	protocatechuate 3,4-dioxygenase
GYK45_RS21805	COG0735	belongs to the Fur family
GYK45_RS21810	COG0354	folic acid binding
GYK45_RS21815	COG1490	D-aminoacyl-tRNA deacylase activity
GYK45_RS21855	COG2249	NAD(P)H dehydrogenase (quinone) activity
GYK45_RS21870	COG4941	Belongs to the sigma-70 factor family
GYK45_RS21900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GYK45_RS21925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GYK45_RS21930	COG0306	phosphate transporter
GYK45_RS21940	COG1937	Protein conserved in bacteria
GYK45_RS21955	COG0277	FAD linked oxidase domain protein
GYK45_RS21960	COG0671	phosphoesterase, PA-phosphatase related
GYK45_RS21965	COG0741	lytic transglycosylase activity
GYK45_RS21965	COG1196	nuclear chromosome segregation
GYK45_RS21965	COG0739	heme binding
GYK45_RS22020	COG1846	Transcriptional regulator
GYK45_RS22060	COG0579	oxidoreductase
GYK45_RS22065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GYK45_RS22075	COG1595	DNA-templated transcription, initiation
GYK45_RS22090	COG1376	ErfK ybiS ycfS ynhG family protein
GYK45_RS22115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GYK45_RS22145	COG0667	Aldo Keto reductase
GYK45_RS22190	COG0513	Belongs to the DEAD box helicase family
GYK45_RS22230	COG0582	viral genome integration into host DNA
GYK45_RS22310	COG0477	Major facilitator Superfamily
GYK45_RS22325	COG1643	Atp-dependent helicase
GYK45_RS22350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYK45_RS22360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GYK45_RS22380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GYK45_RS22385	COG0047	phosphoribosylformylglycinamidine synthase activity
GYK45_RS22390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GYK45_RS22420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GYK45_RS22445	COG0151	Belongs to the GarS family
GYK45_RS22460	COG1802	Transcriptional regulator
GYK45_RS22480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GYK45_RS22480	COG0515	serine threonine protein kinase
GYK45_RS22485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GYK45_RS22500	COG1131	(ABC) transporter
GYK45_RS22505	COG3559	Exporter of polyketide antibiotics
GYK45_RS22510	COG2124	cytochrome p450
GYK45_RS22515	COG2197	response regulator
GYK45_RS22530	COG3844	kynureninase activity
GYK45_RS22545	COG0477	Major facilitator Superfamily
GYK45_RS22555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GYK45_RS22570	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GYK45_RS22640	COG0542	response to heat
GYK45_RS22660	COG0789	Transcriptional regulator
GYK45_RS22665	COG0484	heat shock protein binding
GYK45_RS22670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GYK45_RS22675	COG0443	Heat shock 70 kDa protein
GYK45_RS22680	COG0247	lactate metabolic process
GYK45_RS22680	COG2181	nitrate reductase activity
GYK45_RS22685	COG3290	protein histidine kinase activity
GYK45_RS22700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GYK45_RS22705	COG0717	Belongs to the dCTP deaminase family
GYK45_RS22715	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
GYK45_RS22810	COG0789	Transcriptional regulator
GYK45_RS22885	COG1131	(ABC) transporter
GYK45_RS22915	COG0515	serine threonine protein kinase
GYK45_RS22915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GYK45_RS22950	COG0583	DNA-binding transcription factor activity
GYK45_RS22955	COG0384	phenazine biosynthesis protein PhzF
GYK45_RS22970	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GYK45_RS23000	COG0725	ABC transporter, periplasmic molybdate-binding protein
GYK45_RS23030	COG3938	Belongs to the proline racemase family
GYK45_RS23100	COG1846	Transcriptional regulator
GYK45_RS23140	COG1793	dna ligase
GYK45_RS23190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GYK45_RS23230	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS23245	COG1362	aminopeptidase activity
GYK45_RS23290	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYK45_RS23295	COG0022	dehydrogenase e1 component
GYK45_RS23315	COG0515	serine threonine protein kinase
GYK45_RS23320	COG0515	serine threonine protein kinase
GYK45_RS23340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GYK45_RS23350	COG0746	molybdenum cofactor guanylyltransferase activity
GYK45_RS23370	COG1522	sequence-specific DNA binding
GYK45_RS23380	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS23405	COG3396	Phenylacetate-CoA oxygenase
GYK45_RS23410	COG3460	Phenylacetate-CoA oxygenase
GYK45_RS23415	COG3396	Phenylacetate-CoA oxygenase
GYK45_RS23420	COG2151	metal-sulfur cluster biosynthetic enzyme
GYK45_RS23425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GYK45_RS23435	COG0425	Belongs to the sulfur carrier protein TusA family
GYK45_RS23435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GYK45_RS23450	COG1733	regulation of RNA biosynthetic process
GYK45_RS23455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GYK45_RS23465	COG1716	ATPase activity
GYK45_RS23470	COG1716	ATPase activity
GYK45_RS23485	COG0768	penicillin binding
GYK45_RS23510	COG3764	Sortase (surface protein transpeptidase)
GYK45_RS23525	COG0705	Rhomboid family
GYK45_RS23555	COG0515	serine threonine protein kinase
GYK45_RS23580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GYK45_RS23585	COG0187	DNA topoisomerase II activity
GYK45_RS23590	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GYK45_RS23595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GYK45_RS23600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GYK45_RS23605	COG0592	DNA-directed DNA polymerase activity
GYK45_RS23615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GYK45_RS23620	COG0594	ribonuclease P activity
GYK45_RS23625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GYK45_RS23630	COG0706	membrane insertase activity
GYK45_RS23640	COG0357	Ribosomal RNA small subunit methyltransferase G
GYK45_RS23645	COG1192	Involved in chromosome partitioning
GYK45_RS23675	COG1595	DNA-templated transcription, initiation
GYK45_RS23680	COG0515	serine threonine protein kinase
GYK45_RS23680	COG2815	serine threonine protein kinase
GYK45_RS23695	COG0617	tRNA 3'-terminal CCA addition
GYK45_RS23705	COG1260	myo-inositol-1-phosphate synthase
GYK45_RS23715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYK45_RS23740	COG0360	Binds together with S18 to 16S ribosomal RNA
GYK45_RS23745	COG0629	single-stranded DNA binding
GYK45_RS23750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GYK45_RS23755	COG0359	binds to the 23S rRNA
GYK45_RS23785	COG0667	Aldo Keto reductase
GYK45_RS23810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS23815	COG0242	peptide deformylase activity
GYK45_RS23885	COG0626	cystathionine gamma-synthase activity
GYK45_RS23890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GYK45_RS23895	COG1950	PFAM Membrane protein of
GYK45_RS23900	COG0662	Cupin 2, conserved barrel domain protein
GYK45_RS23925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GYK45_RS23940	COG1609	Transcriptional regulator
GYK45_RS23945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS23950	COG1271	oxidase subunit
GYK45_RS23955	COG1294	oxidase, subunit
GYK45_RS23975	COG0561	phosphatase activity
GYK45_RS23985	COG0501	Belongs to the peptidase M48B family
GYK45_RS24000	COG1131	(ABC) transporter
GYK45_RS24025	COG2807	transmembrane transport
GYK45_RS24050	COG0561	phosphatase activity
GYK45_RS24055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GYK45_RS24065	COG2837	iron assimilation
GYK45_RS24070	COG2372	response to copper ion
GYK45_RS24080	COG1999	signal sequence binding
GYK45_RS24110	COG0006	proline dipeptidase activity
GYK45_RS24125	COG0653	protein targeting
GYK45_RS24140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GYK45_RS24190	COG0494	nUDIX hydrolase
GYK45_RS24300	COG1595	DNA-templated transcription, initiation
GYK45_RS24305	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS24310	COG5000	phosphorelay sensor kinase activity
GYK45_RS24360	COG0024	Methionine aminopeptidase
GYK45_RS24370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS24400	COG0745	RESPONSE REGULATOR receiver
GYK45_RS24405	COG2205	protein histidine kinase activity
GYK45_RS24415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GYK45_RS24415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GYK45_RS24420	COG0477	Major facilitator Superfamily
GYK45_RS24460	COG1191	sigma factor activity
GYK45_RS24465	COG1191	sigma factor activity
GYK45_RS24470	COG0205	6-phosphofructokinase activity
GYK45_RS24500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GYK45_RS24520	COG2124	cytochrome p450
GYK45_RS24540	COG3594	Acyltransferase
GYK45_RS24575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYK45_RS24580	COG0577	efflux transmembrane transporter activity
GYK45_RS24580	COG1136	(ABC) transporter
GYK45_RS24590	COG2197	response regulator
GYK45_RS24595	COG4585	Histidine kinase
GYK45_RS24605	COG1309	transcriptional regulator
GYK45_RS24610	COG2197	response regulator
GYK45_RS24615	COG4585	Histidine kinase
GYK45_RS24620	COG1131	(ABC) transporter
GYK45_RS24630	COG0604	alcohol dehydrogenase
GYK45_RS24630	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS24630	COG3321	synthase
GYK45_RS24690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GYK45_RS24695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GYK45_RS24740	COG2124	cytochrome p450
GYK45_RS24790	COG1408	metallophosphoesterase
GYK45_RS24800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GYK45_RS24810	COG0003	Pfam Anion-transporting ATPase
GYK45_RS24835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYK45_RS24865	COG2267	carboxylic ester hydrolase activity
GYK45_RS24875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GYK45_RS24880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS24975	COG1366	Belongs to the anti-sigma-factor antagonist family
GYK45_RS24980	COG2172	sigma factor antagonist activity
GYK45_RS24985	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GYK45_RS25010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GYK45_RS25045	COG2197	response regulator
GYK45_RS25055	COG0640	Transcriptional regulator
GYK45_RS25065	COG1191	sigma factor activity
GYK45_RS25095	COG4585	Histidine kinase
GYK45_RS25100	COG2197	response regulator
GYK45_RS25105	COG0671	phosphoesterase, PA-phosphatase related
GYK45_RS25155	COG2197	response regulator
GYK45_RS25175	COG1595	DNA-templated transcription, initiation
GYK45_RS25190	COG1077	Cell shape determining protein MreB Mrl
GYK45_RS25195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GYK45_RS25195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GYK45_RS25220	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS25225	COG2318	DinB family
GYK45_RS25250	COG0076	glutamate decarboxylase activity
GYK45_RS25260	COG0789	Transcriptional regulator
GYK45_RS25275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GYK45_RS25315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GYK45_RS25320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GYK45_RS25345	COG1125	glycine betaine transport
GYK45_RS25345	COG0517	IMP dehydrogenase activity
GYK45_RS25350	COG1174	glycine betaine transport
GYK45_RS25355	COG1174	glycine betaine transport
GYK45_RS25370	COG0649	NAD binding
GYK45_RS25385	COG2197	response regulator
GYK45_RS25390	COG0640	Transcriptional regulator
GYK45_RS25395	COG0640	Transcriptional regulator
GYK45_RS25410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GYK45_RS25415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GYK45_RS25425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GYK45_RS25445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GYK45_RS25460	COG0542	response to heat
GYK45_RS25505	COG0737	Belongs to the 5'-nucleotidase family
GYK45_RS25510	COG0456	acetyltransferase
GYK45_RS25510	COG0454	-acetyltransferase
GYK45_RS25515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GYK45_RS25530	COG0667	Aldo Keto reductase
GYK45_RS25550	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS25585	COG0588	phosphoglycerate mutase activity
GYK45_RS25600	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS25605	COG0640	Transcriptional regulator
GYK45_RS25630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GYK45_RS25635	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS25665	COG5002	protein histidine kinase activity
GYK45_RS25685	COG1329	Transcriptional regulator
GYK45_RS25690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GYK45_RS25695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GYK45_RS25700	COG0215	cysteine-tRNA ligase activity
GYK45_RS25725	COG3842	ATPase activity
GYK45_RS25740	COG1136	(ABC) transporter
GYK45_RS25740	COG0577	efflux transmembrane transporter activity
GYK45_RS25760	COG0515	serine threonine protein kinase
GYK45_RS25765	COG2197	response regulator
GYK45_RS25815	COG3903	Transcriptional regulator
GYK45_RS25815	COG3629	intracellular signal transduction
GYK45_RS25830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS25835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS25870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GYK45_RS25875	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS25890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GYK45_RS25930	COG2124	cytochrome p450
GYK45_RS25955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS25970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS25975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS25980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS25995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS26000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GYK45_RS26015	COG1064	alcohol dehydrogenase
GYK45_RS26020	COG1309	transcriptional regulator
GYK45_RS26035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GYK45_RS26080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS26080	COG1877	trehalose-phosphatase activity
GYK45_RS26090	COG0463	Glycosyl transferase, family 2
GYK45_RS26105	COG1278	Cold shock
GYK45_RS26110	COG0459	protein refolding
GYK45_RS26115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GYK45_RS26120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GYK45_RS26165	COG3973	AAA domain
GYK45_RS26175	COG1061	Type III restriction enzyme res subunit
GYK45_RS26195	COG1120	ATPase activity
GYK45_RS26200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS26205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS26220	COG1278	Cold shock
GYK45_RS26225	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GYK45_RS26230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GYK45_RS26265	COG2252	PERMEase
GYK45_RS26285	COG0667	Aldo Keto reductase
GYK45_RS26300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GYK45_RS26305	COG0277	FAD linked oxidase domain protein
GYK45_RS26305	COG0247	lactate metabolic process
GYK45_RS26320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYK45_RS26335	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS26340	COG1024	Enoyl-CoA hydratase
GYK45_RS26345	COG1309	transcriptional regulator
GYK45_RS26355	COG0259	pyridoxamine-phosphate oxidase activity
GYK45_RS26365	COG4821	SIS domain
GYK45_RS26375	COG2945	thiolester hydrolase activity
GYK45_RS26375	COG0596	Alpha beta hydrolase
GYK45_RS26455	COG2197	response regulator
GYK45_RS26505	COG0519	Catalyzes the synthesis of GMP from XMP
GYK45_RS26505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GYK45_RS26530	COG0515	serine threonine protein kinase
GYK45_RS26605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYK45_RS26620	COG0714	Associated with various cellular activities
GYK45_RS26645	COG0045	succinate-CoA ligase (ADP-forming) activity
GYK45_RS26670	COG0138	bifunctional purine biosynthesis protein purh
GYK45_RS26675	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GYK45_RS26690	COG0039	L-malate dehydrogenase activity
GYK45_RS26725	COG0517	IMP dehydrogenase activity
GYK45_RS26725	COG4175	Glycine betaine
GYK45_RS26730	COG4176	ABC-type proline glycine betaine transport system permease component
GYK45_RS26745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS26750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GYK45_RS26760	COG0754	glutathionylspermidine amidase activity
GYK45_RS26765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GYK45_RS26770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GYK45_RS26780	COG0180	Tryptophanyl-tRNA synthetase
GYK45_RS26795	COG1295	ribonuclease BN
GYK45_RS26815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GYK45_RS26830	COG2009	succinate dehydrogenase
GYK45_RS26850	COG1595	DNA-templated transcription, initiation
GYK45_RS26900	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS26905	COG1316	TRANSCRIPTIONal
GYK45_RS26935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS26940	COG2188	Transcriptional regulator
GYK45_RS26945	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GYK45_RS26950	COG2814	Major facilitator Superfamily
GYK45_RS26975	COG2186	Transcriptional regulator
GYK45_RS26980	COG3265	gluconokinase activity
GYK45_RS26990	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS26995	COG1063	alcohol dehydrogenase
GYK45_RS27010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GYK45_RS27020	COG0673	inositol 2-dehydrogenase activity
GYK45_RS27030	COG1309	transcriptional regulator
GYK45_RS27040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GYK45_RS27050	COG1216	Glycosyl transferase, family 2
GYK45_RS27060	COG1083	cytidylyl-transferase
GYK45_RS27065	COG2089	acid synthase
GYK45_RS27075	COG1473	amidohydrolase
GYK45_RS27075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GYK45_RS27110	COG0583	DNA-binding transcription factor activity
GYK45_RS27115	COG2814	Major facilitator Superfamily
GYK45_RS27125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GYK45_RS27150	COG2205	protein histidine kinase activity
GYK45_RS27155	COG0745	RESPONSE REGULATOR receiver
GYK45_RS27160	COG1595	DNA-templated transcription, initiation
GYK45_RS27170	COG2814	Major facilitator Superfamily
GYK45_RS27170	COG0477	Major facilitator Superfamily
GYK45_RS27180	COG2159	amidohydrolase
GYK45_RS27185	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS27190	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS27240	COG4770	biotin carboxylase activity
GYK45_RS27250	COG0424	maF-like protein
GYK45_RS27260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYK45_RS27270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GYK45_RS27280	COG1024	Enoyl-CoA hydratase
GYK45_RS27290	COG2986	histidine ammonia-lyase
GYK45_RS27340	COG3033	Beta-eliminating lyase
GYK45_RS27375	COG2124	cytochrome p450
GYK45_RS27390	COG0148	phosphopyruvate hydratase activity
GYK45_RS27410	COG1252	NADH dehydrogenase
GYK45_RS27415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GYK45_RS27420	COG0577	efflux transmembrane transporter activity
GYK45_RS27425	COG1136	(ABC) transporter
GYK45_RS27425	COG0577	efflux transmembrane transporter activity
GYK45_RS27455	COG0183	Belongs to the thiolase family
GYK45_RS27480	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS27485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GYK45_RS27495	COG1174	glycine betaine transport
GYK45_RS27500	COG1174	glycine betaine transport
GYK45_RS27510	COG2986	histidine ammonia-lyase
GYK45_RS27580	COG1191	sigma factor activity
GYK45_RS27585	COG1366	Belongs to the anti-sigma-factor antagonist family
GYK45_RS27620	COG3104	oligopeptide transport
GYK45_RS27625	COG0745	RESPONSE REGULATOR receiver
GYK45_RS27630	COG2205	protein histidine kinase activity
GYK45_RS27655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GYK45_RS27665	COG1316	TRANSCRIPTIONal
GYK45_RS27670	COG1607	acyl-coa hydrolase
GYK45_RS27675	COG1316	TRANSCRIPTIONal
GYK45_RS27690	COG1316	TRANSCRIPTIONal
GYK45_RS27695	COG1316	TRANSCRIPTIONal
GYK45_RS27720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GYK45_RS27720	COG0778	Nitroreductase
GYK45_RS27755	COG1620	l-lactate permease
GYK45_RS27760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GYK45_RS27765	COG2835	tetraacyldisaccharide 4'-kinase activity
GYK45_RS27775	COG1482	cell wall glycoprotein biosynthetic process
GYK45_RS27785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GYK45_RS27785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GYK45_RS27785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GYK45_RS27820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GYK45_RS27825	COG0745	RESPONSE REGULATOR receiver
GYK45_RS27830	COG5002	protein histidine kinase activity
GYK45_RS27830	COG5000	phosphorelay sensor kinase activity
GYK45_RS27835	COG0823	Involved in the tonB-independent uptake of proteins
GYK45_RS27845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GYK45_RS27855	COG3214	Protein conserved in bacteria
GYK45_RS27865	COG0653	protein targeting
GYK45_RS27880	COG0546	phosphoglycolate phosphatase activity
GYK45_RS27885	COG0693	protein deglycase activity
GYK45_RS27890	COG2902	Dehydrogenase
GYK45_RS27895	COG0463	Glycosyl transferase, family 2
GYK45_RS27895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GYK45_RS27940	COG0463	Glycosyl transferase, family 2
GYK45_RS27940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GYK45_RS27995	COG0395	ABC-type sugar transport system, permease component
GYK45_RS28020	COG0515	serine threonine protein kinase
GYK45_RS28025	COG0515	serine threonine protein kinase
GYK45_RS28030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GYK45_RS28045	COG2884	Cell division ATP-binding protein ftsE
GYK45_RS28055	COG0793	Belongs to the peptidase S41A family
GYK45_RS28060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GYK45_RS28095	COG2027	D-alanyl-D-alanine carboxypeptidase
GYK45_RS28100	COG1501	Belongs to the glycosyl hydrolase 31 family
GYK45_RS28120	COG0583	DNA-binding transcription factor activity
GYK45_RS28135	COG0583	DNA-binding transcription factor activity
GYK45_RS28150	COG2223	nitrite transmembrane transporter activity
GYK45_RS28175	COG3973	AAA domain
GYK45_RS28180	COG1278	Cold shock
GYK45_RS28190	COG0776	regulation of translation
GYK45_RS28195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GYK45_RS28220	COG1175	transmembrane transport
GYK45_RS28225	COG0395	ABC-type sugar transport system, permease component
GYK45_RS28230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GYK45_RS28245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS28250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS28265	COG0270	DNA (cytosine-5-)-methyltransferase activity
GYK45_RS28405	COG2855	membrane
GYK45_RS28420	COG3654	unkown
GYK45_RS28460	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GYK45_RS28475	COG1064	alcohol dehydrogenase
GYK45_RS28505	COG3291	Pkd domain containing protein
GYK45_RS28505	COG4412	M6 family metalloprotease domain protein
GYK45_RS28515	COG1335	isochorismatase
GYK45_RS28525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GYK45_RS28565	COG1263	PTS System
GYK45_RS28565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GYK45_RS28570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GYK45_RS28580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GYK45_RS28600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GYK45_RS28635	COG2733	membrane
GYK45_RS28640	COG3764	Sortase (surface protein transpeptidase)
GYK45_RS28650	COG0706	membrane insertase activity
GYK45_RS28660	COG4702	Belongs to the UPF0303 family
GYK45_RS28665	COG0673	inositol 2-dehydrogenase activity
GYK45_RS28715	COG2186	Transcriptional regulator
GYK45_RS28735	COG3409	Peptidoglycan-binding domain 1 protein
GYK45_RS28750	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS28755	COG0300	oxidoreductase activity
GYK45_RS28790	COG3397	chitin binding
GYK45_RS28825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS28830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GYK45_RS28845	COG1063	alcohol dehydrogenase
GYK45_RS28850	COG0477	Major facilitator Superfamily
GYK45_RS28860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS28865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS28870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS28895	COG0300	oxidoreductase activity
GYK45_RS28920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GYK45_RS28925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS28935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GYK45_RS28940	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS28955	COG4770	biotin carboxylase activity
GYK45_RS28990	COG1126	abc transporter atp-binding protein
GYK45_RS28995	COG0765	amino acid transport
GYK45_RS29000	COG0765	amino acid transport
GYK45_RS29005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GYK45_RS29030	COG3473	Maleate cis-trans isomerase
GYK45_RS29050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS29070	COG2197	response regulator
GYK45_RS29075	COG4585	Histidine kinase
GYK45_RS29175	COG0745	RESPONSE REGULATOR receiver
GYK45_RS29190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GYK45_RS29220	COG5297	Belongs to the glycosyl hydrolase family 6
GYK45_RS29230	COG5297	Belongs to the glycosyl hydrolase family 6
GYK45_RS29230	COG4733	cellulase activity
GYK45_RS29255	COG0789	Transcriptional regulator
GYK45_RS29280	COG4977	sequence-specific DNA binding
GYK45_RS29290	COG0589	response to stress
GYK45_RS29295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GYK45_RS29315	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS29335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GYK45_RS29350	COG1946	Acyl-CoA thioesterase
GYK45_RS29365	COG1278	Cold shock
GYK45_RS29390	COG2205	protein histidine kinase activity
GYK45_RS29395	COG0745	RESPONSE REGULATOR receiver
GYK45_RS29415	COG4585	Histidine kinase
GYK45_RS29420	COG2197	response regulator
GYK45_RS29485	COG0667	Aldo Keto reductase
GYK45_RS29495	COG1846	Transcriptional regulator
GYK45_RS29495	COG0456	acetyltransferase
GYK45_RS29510	COG1609	Transcriptional regulator
GYK45_RS29535	COG1175	transmembrane transport
GYK45_RS29540	COG0395	ABC-type sugar transport system, permease component
GYK45_RS29555	COG0673	inositol 2-dehydrogenase activity
GYK45_RS29605	COG1595	DNA-templated transcription, initiation
GYK45_RS29615	COG1869	D-ribose catabolic process
GYK45_RS29625	COG1879	ABC-type sugar transport system periplasmic component
GYK45_RS29630	COG1129	ABC transporter
GYK45_RS29640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GYK45_RS29665	COG2409	Drug exporters of the RND superfamily
GYK45_RS29675	COG0673	inositol 2-dehydrogenase activity
GYK45_RS29690	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS29700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GYK45_RS29710	COG3718	enzyme involved in inositol metabolism
GYK45_RS29715	COG3962	Belongs to the TPP enzyme family
GYK45_RS29750	COG2197	response regulator
GYK45_RS29755	COG4585	Histidine kinase
GYK45_RS29765	COG3402	PFAM membrane-flanked domain
GYK45_RS29835	COG1131	(ABC) transporter
GYK45_RS29845	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS29870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GYK45_RS29875	COG1993	acr, cog1993
GYK45_RS29880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GYK45_RS29885	COG0142	geranyltranstransferase activity
GYK45_RS29890	COG3251	PFAM MbtH domain protein
GYK45_RS29900	COG0346	lactoylglutathione lyase activity
GYK45_RS29955	COG0629	single-stranded DNA binding
GYK45_RS30020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GYK45_RS30045	COG1175	transmembrane transport
GYK45_RS30055	COG1846	Transcriptional regulator
GYK45_RS30055	COG1940	carbohydrate kinase activity
GYK45_RS30065	COG0668	transmembrane transport
GYK45_RS30135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GYK45_RS30145	COG1113	amino acid transport
GYK45_RS30150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GYK45_RS30185	COG1113	amino acid transport
GYK45_RS30200	COG4552	Acetyltransferase involved in intracellular survival and related
GYK45_RS30220	COG3594	Acyltransferase
GYK45_RS30240	COG0544	peptidyl-prolyl cis-trans isomerase activity
GYK45_RS30245	COG0740	serine-type endopeptidase activity
GYK45_RS30250	COG0740	serine-type endopeptidase activity
GYK45_RS30255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GYK45_RS30280	COG0768	penicillin binding
GYK45_RS30285	COG0285	dihydrofolate synthase activity
GYK45_RS30295	COG0105	UTP biosynthetic process
GYK45_RS30320	COG0772	Belongs to the SEDS family
GYK45_RS30345	COG1530	ribonuclease E activity
GYK45_RS30350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GYK45_RS30355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GYK45_RS30360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GYK45_RS30370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GYK45_RS30395	COG0501	Belongs to the peptidase M48B family
GYK45_RS30400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GYK45_RS30410	COG0799	negative regulation of ribosome biogenesis
GYK45_RS30415	COG0588	phosphoglycerate mutase activity
GYK45_RS30445	COG0495	leucyl-tRNA aminoacylation
GYK45_RS30455	COG1307	EDD domain protein, DegV family
GYK45_RS30460	COG1555	photosystem II stabilization
GYK45_RS30530	COG0268	Binds directly to 16S ribosomal RNA
GYK45_RS30535	COG0481	GTPase activity
GYK45_RS30540	COG1022	Amp-dependent synthetase and ligase
GYK45_RS30565	COG1420	regulation of RNA biosynthetic process
GYK45_RS30570	COG0484	heat shock protein binding
GYK45_RS30590	COG0537	adenosine 5'-monophosphoramidase activity
GYK45_RS30595	COG1234	tRNA 3'-trailer cleavage
GYK45_RS30610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GYK45_RS30635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GYK45_RS30655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYK45_RS30665	COG2409	Drug exporters of the RND superfamily
GYK45_RS30670	COG4585	Histidine kinase
GYK45_RS30675	COG2197	response regulator
GYK45_RS30700	COG0456	acetyltransferase
GYK45_RS30700	COG0454	-acetyltransferase
GYK45_RS30715	COG2315	Protein conserved in bacteria
GYK45_RS30770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GYK45_RS30775	COG0667	Aldo Keto reductase
GYK45_RS30855	COG1121	(ABC) transporter
GYK45_RS30865	COG0423	glycine-tRNA ligase activity
GYK45_RS30880	COG0667	Aldo Keto reductase
GYK45_RS30885	COG0477	Major facilitator Superfamily
GYK45_RS30925	COG0574	Belongs to the PEP-utilizing enzyme family
GYK45_RS30925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GYK45_RS30955	COG2197	response regulator
GYK45_RS30960	COG4585	Histidine kinase
GYK45_RS30975	COG0156	8-amino-7-oxononanoate synthase activity
GYK45_RS30985	COG0395	ABC-type sugar transport system, permease component
GYK45_RS31000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS31015	COG3485	protocatechuate 3,4-dioxygenase
GYK45_RS31020	COG0183	Belongs to the thiolase family
GYK45_RS31030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GYK45_RS31035	COG1846	Transcriptional regulator
GYK45_RS31040	COG2890	protein-(glutamine-N5) methyltransferase activity
GYK45_RS31065	COG1175	transmembrane transport
GYK45_RS31075	COG1609	Transcriptional regulator
GYK45_RS31095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GYK45_RS31095	COG2146	nitrite reductase [NAD(P)H] activity
GYK45_RS31100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GYK45_RS31100	COG2146	nitrite reductase [NAD(P)H] activity
GYK45_RS31115	COG2124	cytochrome p450
GYK45_RS31140	COG5002	protein histidine kinase activity
GYK45_RS31145	COG0745	RESPONSE REGULATOR receiver
GYK45_RS31190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GYK45_RS31195	COG0243	molybdopterin cofactor binding
GYK45_RS31205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GYK45_RS31225	COG1070	Carbohydrate kinase
GYK45_RS31295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GYK45_RS31300	COG0588	phosphoglycerate mutase activity
GYK45_RS31315	COG1414	Transcriptional regulator
GYK45_RS31320	COG3386	PFAM SMP-30 Gluconolaconase
GYK45_RS31390	COG0640	Transcriptional regulator
GYK45_RS31410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GYK45_RS31445	COG4214	carbohydrate transport
GYK45_RS31450	COG1129	ABC transporter
GYK45_RS31515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GYK45_RS31520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS31525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GYK45_RS31550	COG0789	Transcriptional regulator
GYK45_RS31555	COG0667	Aldo Keto reductase
GYK45_RS31565	COG2197	response regulator
GYK45_RS31570	COG4585	Histidine kinase
GYK45_RS31585	COG1309	transcriptional regulator
GYK45_RS31590	COG0477	Major facilitator Superfamily
GYK45_RS31600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GYK45_RS31680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GYK45_RS31725	COG4585	Histidine kinase
GYK45_RS31730	COG2197	response regulator
GYK45_RS31785	COG1846	Transcriptional regulator
GYK45_RS31790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GYK45_RS31800	COG1959	2 iron, 2 sulfur cluster binding
GYK45_RS31810	COG0277	FAD linked oxidase domain protein
GYK45_RS31815	COG0300	oxidoreductase activity
GYK45_RS31835	COG0740	serine-type endopeptidase activity
GYK45_RS31840	COG0740	serine-type endopeptidase activity
GYK45_RS31855	COG1396	sequence-specific DNA binding
GYK45_RS31960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GYK45_RS31980	COG5002	protein histidine kinase activity
GYK45_RS31985	COG0745	RESPONSE REGULATOR receiver
GYK45_RS32005	COG0596	Alpha beta hydrolase
GYK45_RS32030	COG2207	Transcriptional regulator
GYK45_RS32055	COG0183	Belongs to the thiolase family
GYK45_RS32065	COG3845	ABC transporter
GYK45_RS32115	COG2197	response regulator
GYK45_RS32120	COG1309	transcriptional regulator
GYK45_RS32125	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS32145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS32155	COG0860	N-Acetylmuramoyl-L-alanine amidase
GYK45_RS32165	COG2197	response regulator
GYK45_RS32170	COG4585	Histidine kinase
GYK45_RS32180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GYK45_RS32185	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS32200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GYK45_RS32205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GYK45_RS32215	COG0328	RNA-DNA hybrid ribonuclease activity
GYK45_RS32215	COG0406	alpha-ribazole phosphatase activity
GYK45_RS32220	COG0800	Aldolase
GYK45_RS32225	COG3022	response to hydroperoxide
GYK45_RS32245	COG0473	3-isopropylmalate dehydrogenase activity
GYK45_RS32250	COG0583	DNA-binding transcription factor activity
GYK45_RS32255	COG0596	Alpha beta hydrolase
GYK45_RS32270	COG1414	Transcriptional regulator
GYK45_RS32320	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS32325	COG3540	Alkaline phosphatase
GYK45_RS32335	COG2814	Major facilitator Superfamily
GYK45_RS32340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GYK45_RS32365	COG0672	)-iron permease
GYK45_RS32370	COG2837	iron assimilation
GYK45_RS32375	COG2822	iron ion transport
GYK45_RS32420	COG1175	transmembrane transport
GYK45_RS32425	COG0395	ABC-type sugar transport system, permease component
GYK45_RS32440	COG1994	Peptidase M50
GYK45_RS32460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GYK45_RS32465	COG0477	Major facilitator Superfamily
GYK45_RS32470	COG1309	transcriptional regulator
GYK45_RS32480	COG2814	Major facilitator Superfamily
GYK45_RS32485	COG2267	carboxylic ester hydrolase activity
GYK45_RS32490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GYK45_RS32490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYK45_RS32495	COG2132	Multicopper oxidase
GYK45_RS32500	COG0174	glutamine synthetase
GYK45_RS32505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GYK45_RS32555	COG0561	phosphatase activity
GYK45_RS32565	COG1609	Transcriptional regulator
GYK45_RS32575	COG2182	Extracellular solute-binding protein
GYK45_RS32585	COG3833	ABC-type maltose transport systems, permease component
GYK45_RS32600	COG1063	alcohol dehydrogenase
GYK45_RS32650	COG0745	RESPONSE REGULATOR receiver
GYK45_RS32670	COG0477	Major facilitator Superfamily
GYK45_RS32700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GYK45_RS32710	COG1280	lysine exporter protein (LysE YggA)
GYK45_RS32750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GYK45_RS32765	COG0640	Transcriptional regulator
GYK45_RS32795	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS32805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GYK45_RS32815	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYK45_RS32820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GYK45_RS32825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GYK45_RS32830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GYK45_RS32835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GYK45_RS32875	COG2197	response regulator
GYK45_RS32880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GYK45_RS32910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GYK45_RS32915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GYK45_RS32935	COG1845	cytochrome c oxidase, subunit III
GYK45_RS32940	COG2010	Cytochrome c
GYK45_RS32945	COG0723	plastoquinol--plastocyanin reductase activity
GYK45_RS32950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GYK45_RS32955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GYK45_RS33030	COG1940	carbohydrate kinase activity
GYK45_RS33060	COG2197	response regulator
GYK45_RS33065	COG0205	6-phosphofructokinase activity
GYK45_RS33085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GYK45_RS33090	COG0243	molybdopterin cofactor binding
GYK45_RS33095	COG2193	ferroxidase activity
GYK45_RS33100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GYK45_RS33110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GYK45_RS33120	COG2815	serine threonine protein kinase
GYK45_RS33120	COG0515	serine threonine protein kinase
GYK45_RS33130	COG2022	thiamine diphosphate biosynthetic process
GYK45_RS33145	COG0446	pyridine nucleotide-disulphide oxidoreductase
GYK45_RS33155	COG0352	thiamine-phosphate diphosphorylase activity
GYK45_RS33175	COG1309	transcriptional regulator
GYK45_RS33185	COG1129	ABC transporter
GYK45_RS33215	COG0714	Associated with various cellular activities
GYK45_RS33240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GYK45_RS33250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GYK45_RS33275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GYK45_RS33290	COG1799	cell septum assembly
GYK45_RS33305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GYK45_RS33310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GYK45_RS33365	COG0587	DNA-directed DNA polymerase activity
GYK45_RS33405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GYK45_RS33410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GYK45_RS33425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS33430	COG0131	Imidazoleglycerol-phosphate dehydratase
GYK45_RS33440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GYK45_RS33445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GYK45_RS33450	COG0251	oxidation-reduction process
GYK45_RS33455	COG0107	imidazoleglycerol-phosphate synthase activity
GYK45_RS33470	COG0789	Transcriptional regulator
GYK45_RS33475	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS33510	COG4221	oxidoreductase activity
GYK45_RS33530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GYK45_RS33535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GYK45_RS33555	COG0134	indole-3-glycerol-phosphate synthase activity
GYK45_RS33560	COG0133	tryptophan synthase activity
GYK45_RS33565	COG0159	tryptophan synthase activity
GYK45_RS33575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GYK45_RS33585	COG0069	glutamate synthase activity
GYK45_RS33585	COG0070	glutamate synthase
GYK45_RS33585	COG0067	glutamate synthase
GYK45_RS33595	COG1725	Transcriptional regulator
GYK45_RS33600	COG1131	(ABC) transporter
GYK45_RS33620	COG3467	pyridoxamine 5'-phosphate
GYK45_RS33640	COG0287	Prephenate dehydrogenase
GYK45_RS33640	COG1605	Chorismate mutase
GYK45_RS33655	COG0076	glutamate decarboxylase activity
GYK45_RS33665	COG0737	Belongs to the 5'-nucleotidase family
GYK45_RS33695	COG0410	ABC transporter
GYK45_RS33700	COG0411	ABC transporter
GYK45_RS33725	COG2050	protein possibly involved in aromatic compounds catabolism
GYK45_RS33770	COG1643	Atp-dependent helicase
GYK45_RS33795	COG0237	dephospho-CoA kinase activity
GYK45_RS33850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GYK45_RS33860	COG0556	nucleotide-excision repair
GYK45_RS33875	COG0861	Integral membrane protein TerC family
GYK45_RS33880	COG0477	Major facilitator Superfamily
GYK45_RS33895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GYK45_RS33915	COG0322	excinuclease ABC activity
GYK45_RS33920	COG1660	Displays ATPase and GTPase activities
GYK45_RS33925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GYK45_RS33940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GYK45_RS33945	COG0126	phosphoglycerate kinase activity
GYK45_RS33950	COG0149	triose-phosphate isomerase activity
GYK45_RS33955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GYK45_RS33970	COG0166	Belongs to the GPI family
GYK45_RS33975	COG0363	glucosamine-6-phosphate deaminase activity
GYK45_RS33990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GYK45_RS34000	COG0109	protoheme IX farnesyltransferase activity
GYK45_RS34015	COG1612	heme a metabolic process
GYK45_RS34040	COG0719	Fe-S assembly protein
GYK45_RS34050	COG0396	ATPase activity
GYK45_RS34060	COG0822	iron-sulfur transferase activity
GYK45_RS34065	COG2151	metal-sulfur cluster biosynthetic enzyme
GYK45_RS34070	COG2076	Multidrug Resistance protein
GYK45_RS34135	COG0477	Major facilitator Superfamily
GYK45_RS34140	COG1335	isochorismatase
GYK45_RS34145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS34155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYK45_RS34160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS34185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS34220	COG0726	polysaccharide deacetylase
GYK45_RS34250	COG1414	Transcriptional regulator
GYK45_RS34260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GYK45_RS34265	COG5285	phytanoyl-CoA dioxygenase
GYK45_RS34270	COG1917	Cupin 2, conserved barrel domain protein
GYK45_RS34280	COG0456	acetyltransferase
GYK45_RS34340	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GYK45_RS34350	COG0235	Class ii aldolase
GYK45_RS34365	COG0488	(ABC) transporter
GYK45_RS34385	COG2205	protein histidine kinase activity
GYK45_RS34385	COG4999	Histidine kinase
GYK45_RS34385	COG3850	Histidine kinase
GYK45_RS34385	COG3437	response regulator, receiver
GYK45_RS34390	COG3706	GGDEF domain
GYK45_RS34390	COG0745	RESPONSE REGULATOR receiver
GYK45_RS34430	COG3387	PFAM Glycoside hydrolase 15-related
GYK45_RS34445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GYK45_RS34480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYK45_RS34485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GYK45_RS34505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GYK45_RS34560	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS34565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GYK45_RS34575	COG2186	Transcriptional regulator
GYK45_RS34580	COG2807	transmembrane transport
GYK45_RS34600	COG0560	Phosphoserine phosphatase
GYK45_RS34600	COG3830	Belongs to the UPF0237 family
GYK45_RS34610	COG0842	Transport permease protein
GYK45_RS34610	COG1131	(ABC) transporter
GYK45_RS34610	COG1716	ATPase activity
GYK45_RS34625	COG2197	response regulator
GYK45_RS34640	COG1119	ATPase activity
GYK45_RS34660	COG1881	PFAM PEBP family protein
GYK45_RS34675	COG2094	Belongs to the DNA glycosylase MPG family
GYK45_RS34710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS34745	COG0497	DNA recombination
GYK45_RS34750	COG0297	glycogen (starch) synthase activity
GYK45_RS34765	COG3387	PFAM Glycoside hydrolase 15-related
GYK45_RS34775	COG0494	nUDIX hydrolase
GYK45_RS34780	COG3903	Transcriptional regulator
GYK45_RS34780	COG3629	intracellular signal transduction
GYK45_RS34785	COG0686	Belongs to the AlaDH PNT family
GYK45_RS34800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GYK45_RS34805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GYK45_RS34810	COG1187	pseudouridine synthase activity
GYK45_RS34825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GYK45_RS34835	COG1160	GTP binding
GYK45_RS34850	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS34865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GYK45_RS34915	COG0671	phosphoesterase, PA-phosphatase related
GYK45_RS34925	COG0477	Major facilitator Superfamily
GYK45_RS34930	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS34935	COG1799	cell septum assembly
GYK45_RS34955	COG1126	abc transporter atp-binding protein
GYK45_RS34995	COG3467	pyridoxamine 5'-phosphate
GYK45_RS35005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GYK45_RS35025	COG1764	response to oxidative stress
GYK45_RS35030	COG1846	Transcriptional regulator
GYK45_RS35060	COG4264	IucA IucC family
GYK45_RS35065	COG0019	diaminopimelate decarboxylase activity
GYK45_RS35075	COG4977	sequence-specific DNA binding
GYK45_RS35095	COG0519	Catalyzes the synthesis of GMP from XMP
GYK45_RS35095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GYK45_RS35120	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS35135	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS35170	COG2409	Drug exporters of the RND superfamily
GYK45_RS35175	COG4585	Histidine kinase
GYK45_RS35190	COG2814	Major facilitator Superfamily
GYK45_RS35225	COG1725	Transcriptional regulator
GYK45_RS35230	COG1834	amidinotransferase
GYK45_RS35260	COG2755	lipolytic protein G-D-S-L family
GYK45_RS35265	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GYK45_RS35295	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GYK45_RS35300	COG1309	transcriptional regulator
GYK45_RS35305	COG3383	formate dehydrogenase (NAD+) activity
GYK45_RS35310	COG2851	Citrate transporter
GYK45_RS35335	COG2409	Drug exporters of the RND superfamily
GYK45_RS35345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS35365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYK45_RS35375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GYK45_RS35425	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS35470	COG2149	membrane
GYK45_RS35475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GYK45_RS35510	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS35530	COG0702	epimerase
GYK45_RS35550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GYK45_RS35555	COG2080	2 iron, 2 sulfur cluster binding
GYK45_RS35560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GYK45_RS35580	COG0297	glycogen (starch) synthase activity
GYK45_RS35600	COG4221	oxidoreductase activity
GYK45_RS35645	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GYK45_RS35650	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GYK45_RS35655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GYK45_RS35695	COG0667	Aldo Keto reductase
GYK45_RS35700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS35715	COG0598	Magnesium transport protein CorA
GYK45_RS35735	COG0215	cysteine-tRNA ligase activity
GYK45_RS35750	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS35760	COG1129	ABC transporter
GYK45_RS35765	COG4211	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS35780	COG2186	Transcriptional regulator
GYK45_RS35790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GYK45_RS35795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS35800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GYK45_RS35805	COG1414	Transcriptional regulator
GYK45_RS35810	COG1410	methionine synthase
GYK45_RS35810	COG0646	methionine synthase
GYK45_RS35815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS35840	COG0517	IMP dehydrogenase activity
GYK45_RS35840	COG1994	Peptidase M50
GYK45_RS35860	COG1222	aaa ATPase
GYK45_RS35865	COG4122	O-methyltransferase activity
GYK45_RS35875	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GYK45_RS35880	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GYK45_RS35885	COG1609	Transcriptional regulator
GYK45_RS35895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GYK45_RS35900	COG0545	Peptidyl-prolyl cis-trans isomerase
GYK45_RS35910	COG2378	regulation of single-species biofilm formation
GYK45_RS35930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GYK45_RS35935	COG0805	protein transport
GYK45_RS35960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GYK45_RS35965	COG4175	Glycine betaine
GYK45_RS35965	COG0517	IMP dehydrogenase activity
GYK45_RS35990	COG1228	amidohydrolase
GYK45_RS35995	COG2267	carboxylic ester hydrolase activity
GYK45_RS36000	COG3958	Transketolase
GYK45_RS36005	COG3959	Transketolase, thiamine diphosphate binding domain
GYK45_RS36040	COG0649	NAD binding
GYK45_RS36095	COG4585	Histidine kinase
GYK45_RS36100	COG2197	response regulator
GYK45_RS36105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GYK45_RS36105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GYK45_RS36125	COG1278	Cold shock
GYK45_RS36130	COG0513	Belongs to the DEAD box helicase family
GYK45_RS36155	COG0531	amino acid
GYK45_RS36160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GYK45_RS36165	COG0583	DNA-binding transcription factor activity
GYK45_RS36240	COG1611	Belongs to the LOG family
GYK45_RS36245	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS36250	COG2226	methyltransferase
GYK45_RS36260	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS36270	COG1250	3-hydroxyacyl-CoA dehydrogenase
GYK45_RS36300	COG3958	Transketolase
GYK45_RS36305	COG3959	Transketolase, thiamine diphosphate binding domain
GYK45_RS36310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GYK45_RS36340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GYK45_RS36345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS36375	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS36390	COG2208	phosphoserine phosphatase activity
GYK45_RS36405	COG0443	Heat shock 70 kDa protein
GYK45_RS36410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GYK45_RS36425	COG0542	response to heat
GYK45_RS36445	COG0071	Belongs to the small heat shock protein (HSP20) family
GYK45_RS36460	COG0531	amino acid
GYK45_RS36510	COG0778	Nitroreductase
GYK45_RS36550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYK45_RS36560	COG0277	FAD linked oxidase domain protein
GYK45_RS36585	COG0583	DNA-binding transcription factor activity
GYK45_RS36595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS36600	COG1024	Enoyl-CoA hydratase
GYK45_RS36605	COG1024	Enoyl-CoA hydratase
GYK45_RS36630	COG0477	Major facilitator Superfamily
GYK45_RS36645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS36675	COG0563	adenylate kinase activity
GYK45_RS36685	COG2807	transmembrane transport
GYK45_RS36690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GYK45_RS36725	COG2318	DinB family
GYK45_RS36730	COG0583	DNA-binding transcription factor activity
GYK45_RS36735	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS36750	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS36765	COG0516	GMP reductase activity
GYK45_RS36765	COG0517	IMP dehydrogenase activity
GYK45_RS36775	COG0517	IMP dehydrogenase activity
GYK45_RS36790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS36805	COG0583	DNA-binding transcription factor activity
GYK45_RS36870	COG1408	metallophosphoesterase
GYK45_RS36885	COG1476	TRANSCRIPTIONal
GYK45_RS36915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GYK45_RS36920	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GYK45_RS36930	COG1215	transferase activity, transferring glycosyl groups
GYK45_RS36940	COG4310	Domain of unknown function (DUF2172)
GYK45_RS36955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GYK45_RS37020	COG1733	regulation of RNA biosynthetic process
GYK45_RS37055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GYK45_RS37060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS37090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GYK45_RS37105	COG2226	methyltransferase
GYK45_RS37110	COG0446	pyridine nucleotide-disulphide oxidoreductase
GYK45_RS37110	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS37115	COG1703	isobutyryl-CoA mutase activity
GYK45_RS37115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYK45_RS37115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GYK45_RS37185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GYK45_RS37190	COG2192	nodulation
GYK45_RS37215	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS37220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GYK45_RS37230	COG0859	PFAM glycosyl transferase family 9
GYK45_RS37255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GYK45_RS37270	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS37275	COG0477	Major facilitator Superfamily
GYK45_RS37315	COG0154	amidase activity
GYK45_RS37325	COG1309	transcriptional regulator
GYK45_RS37330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GYK45_RS37360	COG1309	transcriptional regulator
GYK45_RS37365	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS37375	COG2207	Transcriptional regulator
GYK45_RS37390	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS37415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GYK45_RS37420	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS37495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GYK45_RS37505	COG0667	Aldo Keto reductase
GYK45_RS37510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GYK45_RS37570	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS37575	COG1309	transcriptional regulator
GYK45_RS37590	COG0009	L-threonylcarbamoyladenylate synthase
GYK45_RS37605	COG1609	Transcriptional regulator
GYK45_RS37645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS37655	COG4221	oxidoreductase activity
GYK45_RS37670	COG3848	Pyruvate phosphate dikinase
GYK45_RS37670	COG0574	Belongs to the PEP-utilizing enzyme family
GYK45_RS37735	COG1940	carbohydrate kinase activity
GYK45_RS37735	COG1846	Transcriptional regulator
GYK45_RS37740	COG0395	ABC-type sugar transport system, permease component
GYK45_RS37755	COG1063	alcohol dehydrogenase
GYK45_RS37760	COG1082	Xylose isomerase domain protein TIM barrel
GYK45_RS37790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS37795	COG0473	3-isopropylmalate dehydrogenase activity
GYK45_RS37795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GYK45_RS37850	COG2376	Dihydroxyacetone kinase
GYK45_RS37875	COG2267	carboxylic ester hydrolase activity
GYK45_RS37920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GYK45_RS37930	COG3469	chitinase activity
GYK45_RS37940	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS37945	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS37955	COG1129	ABC transporter
GYK45_RS37965	COG3548	integral membrane protein
GYK45_RS37975	COG2207	Transcriptional regulator
GYK45_RS37980	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS37985	COG0596	Alpha beta hydrolase
GYK45_RS38020	COG3469	chitinase activity
GYK45_RS38035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GYK45_RS38085	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38130	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS38185	COG2205	protein histidine kinase activity
GYK45_RS38190	COG0745	RESPONSE REGULATOR receiver
GYK45_RS38235	COG0477	Major facilitator Superfamily
GYK45_RS38260	COG3971	2-oxopent-4-enoate hydratase activity
GYK45_RS38270	COG1309	transcriptional regulator
GYK45_RS38275	COG1414	Transcriptional regulator
GYK45_RS38280	COG0667	Aldo Keto reductase
GYK45_RS38330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS38335	COG1595	DNA-templated transcription, initiation
GYK45_RS38345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS38365	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38375	COG0596	Alpha beta hydrolase
GYK45_RS38400	COG0251	oxidation-reduction process
GYK45_RS38425	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38435	COG3961	Belongs to the TPP enzyme family
GYK45_RS38440	COG1231	oxidoreductase activity
GYK45_RS38455	COG0583	DNA-binding transcription factor activity
GYK45_RS38465	COG2814	Major facilitator Superfamily
GYK45_RS38475	COG0656	L-ascorbic acid biosynthetic process
GYK45_RS38485	COG1129	ABC transporter
GYK45_RS38490	COG1172	Belongs to the binding-protein-dependent transport system permease family
GYK45_RS38500	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38520	COG1070	Carbohydrate kinase
GYK45_RS38530	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38535	COG1063	alcohol dehydrogenase
GYK45_RS38540	COG1063	alcohol dehydrogenase
GYK45_RS38545	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38550	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38555	COG0477	Major facilitator Superfamily
GYK45_RS38560	COG1063	alcohol dehydrogenase
GYK45_RS38565	COG3959	Transketolase, thiamine diphosphate binding domain
GYK45_RS38570	COG3958	Transketolase
GYK45_RS38575	COG1414	Transcriptional regulator
GYK45_RS38605	COG0800	Aldolase
GYK45_RS38610	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS38620	COG1063	alcohol dehydrogenase
GYK45_RS38625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS38635	COG2140	Oxalate decarboxylase
GYK45_RS38640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYK45_RS38645	COG1737	Transcriptional regulator
GYK45_RS38665	COG0583	DNA-binding transcription factor activity
GYK45_RS38690	COG1846	Transcriptional regulator
GYK45_RS38695	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS38705	COG0596	Alpha beta hydrolase
GYK45_RS38725	COG0604	alcohol dehydrogenase
GYK45_RS38740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GYK45_RS38765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GYK45_RS38785	COG2226	methyltransferase
GYK45_RS38790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS38810	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS38815	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS38865	COG4566	intracellular signal transduction
GYK45_RS38870	COG3629	intracellular signal transduction
GYK45_RS38870	COG3903	Transcriptional regulator
GYK45_RS38875	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS38880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYK45_RS38900	COG2226	methyltransferase
GYK45_RS38930	COG0395	ABC-type sugar transport system, permease component
GYK45_RS38950	COG1414	Transcriptional regulator
GYK45_RS38960	COG0673	inositol 2-dehydrogenase activity
GYK45_RS39000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GYK45_RS39005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYK45_RS39010	COG2188	Transcriptional regulator
GYK45_RS39015	COG4689	acetoacetate decarboxylase
GYK45_RS39025	COG0179	Fumarylacetoacetate (FAA) hydrolase
GYK45_RS39040	COG1846	Transcriptional regulator
GYK45_RS39045	COG0174	glutamine synthetase
GYK45_RS39070	COG0842	Transport permease protein
GYK45_RS39075	COG3850	Histidine kinase
GYK45_RS39085	COG0596	Alpha beta hydrolase
GYK45_RS39095	COG3639	organic phosphonate transmembrane transporter activity
GYK45_RS39105	COG3940	Belongs to the glycosyl hydrolase 43 family
GYK45_RS39110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GYK45_RS39120	COG3119	arylsulfatase activity
GYK45_RS39125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS39205	COG1116	anion transmembrane transporter activity
GYK45_RS39210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS39250	COG2706	6-phosphogluconolactonase activity
GYK45_RS39270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GYK45_RS39280	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS39285	COG0640	Transcriptional regulator
GYK45_RS39290	COG2233	PERMEase
GYK45_RS39345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYK45_RS39360	COG0259	pyridoxamine-phosphate oxidase activity
GYK45_RS39395	COG3293	Transposase
GYK45_RS39405	COG1309	transcriptional regulator
GYK45_RS39420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GYK45_RS39425	COG1120	ATPase activity
GYK45_RS39435	COG0367	asparagine synthase
GYK45_RS39470	COG0456	acetyltransferase
GYK45_RS39480	COG0671	phosphoesterase, PA-phosphatase related
GYK45_RS39515	COG0584	glycerophosphoryl diester phosphodiesterase
GYK45_RS39555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GYK45_RS39590	COG1940	carbohydrate kinase activity
GYK45_RS39595	COG0515	serine threonine protein kinase
GYK45_RS39595	COG2815	serine threonine protein kinase
GYK45_RS39600	COG3345	alpha-galactosidase
GYK45_RS39620	COG1660	Displays ATPase and GTPase activities
GYK45_RS39630	COG0445	tRNA wobble uridine modification
GYK45_RS39635	COG4585	Histidine kinase
GYK45_RS39640	COG2197	response regulator
GYK45_RS39670	COG1940	carbohydrate kinase activity
GYK45_RS39705	COG1349	DNA-binding transcription factor activity
GYK45_RS39715	COG0464	growth
GYK45_RS39780	COG1051	belongs to the nudix hydrolase family
GYK45_RS39785	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS39805	COG2124	cytochrome p450
GYK45_RS39810	COG2124	cytochrome p450
GYK45_RS39820	COG0142	geranyltranstransferase activity
GYK45_RS39825	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GYK45_RS39825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GYK45_RS39825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GYK45_RS39830	COG1461	Dihydroxyacetone kinase
GYK45_RS39835	COG2376	Dihydroxyacetone kinase
GYK45_RS39845	COG1960	acyl-CoA dehydrogenase activity
GYK45_RS39870	COG4249	Peptidase C14 caspase catalytic subunit p20
GYK45_RS39870	COG2319	Wd-40 repeat
GYK45_RS39880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GYK45_RS39905	COG0515	serine threonine protein kinase
GYK45_RS39915	COG2070	2-Nitropropane dioxygenase
GYK45_RS39940	COG1024	Enoyl-CoA hydratase
GYK45_RS39970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS40015	COG0438	transferase activity, transferring glycosyl groups
GYK45_RS40035	COG1984	allophanate hydrolase subunit 2
GYK45_RS40040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GYK45_RS40045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GYK45_RS40065	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GYK45_RS40105	COG4638	Rieske (2fe-2S)
GYK45_RS40125	COG2146	nitrite reductase [NAD(P)H] activity
GYK45_RS40145	COG2018	Roadblock/LC7 domain
GYK45_RS40160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS40165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GYK45_RS40170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GYK45_RS40180	COG3842	ATPase activity
GYK45_RS40185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GYK45_RS40190	COG1176	ABC-type spermidine putrescine transport system, permease component I
GYK45_RS40195	COG1177	transmembrane transport
GYK45_RS40200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GYK45_RS40215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GYK45_RS40220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GYK45_RS40235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GYK45_RS40285	COG1716	ATPase activity
GYK45_RS40380	COG0697	spore germination
GYK45_RS40385	COG0583	DNA-binding transcription factor activity
GYK45_RS40405	COG0488	(ABC) transporter
GYK45_RS40415	COG0477	Major facilitator Superfamily
GYK45_RS40425	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS40430	COG0583	DNA-binding transcription factor activity
GYK45_RS40440	COG4941	Belongs to the sigma-70 factor family
GYK45_RS40445	COG3795	YCII-related domain
GYK45_RS40450	COG3547	Transposase (IS116 IS110 IS902 family)
GYK45_RS40475	COG1053	succinate dehydrogenase
GYK45_RS40480	COG1764	response to oxidative stress
GYK45_RS40485	COG1595	DNA-templated transcription, initiation
GYK45_RS40500	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS40530	COG3485	protocatechuate 3,4-dioxygenase
GYK45_RS40545	COG2909	trisaccharide binding
GYK45_RS40560	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS40575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS40595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GYK45_RS40600	COG0384	phenazine biosynthesis protein PhzF
GYK45_RS40620	COG1522	sequence-specific DNA binding
GYK45_RS40635	COG2072	flavoprotein involved in K transport
GYK45_RS40660	COG0583	DNA-binding transcription factor activity
GYK45_RS40685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GYK45_RS40745	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS40765	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS40775	COG0494	nUDIX hydrolase
GYK45_RS40780	COG3655	Transcriptional regulator
GYK45_RS40795	COG2755	lipolytic protein G-D-S-L family
GYK45_RS40800	COG0277	FAD linked oxidase domain protein
GYK45_RS40800	COG0247	lactate metabolic process
GYK45_RS40805	COG0028	Belongs to the TPP enzyme family
GYK45_RS40865	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS40870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GYK45_RS40880	COG2378	regulation of single-species biofilm formation
GYK45_RS40915	COG2318	DinB family
GYK45_RS40930	COG0673	inositol 2-dehydrogenase activity
GYK45_RS40935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GYK45_RS40945	COG1879	ABC-type sugar transport system periplasmic component
GYK45_RS40950	COG2186	Transcriptional regulator
GYK45_RS40955	COG1113	amino acid transport
GYK45_RS40990	COG0723	plastoquinol--plastocyanin reductase activity
GYK45_RS40990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GYK45_RS41015	COG1024	Enoyl-CoA hydratase
GYK45_RS41020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GYK45_RS41025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GYK45_RS41030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GYK45_RS41035	COG0254	rRNA binding
GYK45_RS41045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GYK45_RS41065	COG0640	Transcriptional regulator
GYK45_RS41090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GYK45_RS41100	COG2318	DinB family
GYK45_RS41110	COG0583	DNA-binding transcription factor activity
GYK45_RS41145	COG1222	aaa ATPase
GYK45_RS41220	COG1309	transcriptional regulator
GYK45_RS41225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GYK45_RS41230	COG1819	glycosyl
GYK45_RS41240	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS41255	COG1316	TRANSCRIPTIONal
GYK45_RS41295	COG1959	2 iron, 2 sulfur cluster binding
GYK45_RS41335	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS41365	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS41385	COG4585	Histidine kinase
GYK45_RS41390	COG2197	response regulator
GYK45_RS41395	COG0577	efflux transmembrane transporter activity
GYK45_RS41395	COG1136	(ABC) transporter
GYK45_RS41410	COG2197	response regulator
GYK45_RS41415	COG4585	Histidine kinase
GYK45_RS41425	COG3046	protein related to deoxyribodipyrimidine photolyase
GYK45_RS41440	COG0277	FAD linked oxidase domain protein
GYK45_RS41455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GYK45_RS41460	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GYK45_RS41475	COG2353	YceI-like domain
GYK45_RS41495	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS41505	COG0137	argininosuccinate synthase activity
GYK45_RS41515	COG0366	Alpha amylase catalytic
GYK45_RS41540	COG0587	DNA-directed DNA polymerase activity
GYK45_RS41660	COG0604	alcohol dehydrogenase
GYK45_RS41660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS41660	COG3321	synthase
GYK45_RS41660	COG4221	oxidoreductase activity
GYK45_RS41755	COG3467	pyridoxamine 5'-phosphate
GYK45_RS41775	COG5006	permease, DMT superfamily
GYK45_RS41805	COG0789	Transcriptional regulator
GYK45_RS41860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GYK45_RS41890	COG1063	alcohol dehydrogenase
GYK45_RS41895	COG0778	Nitroreductase
GYK45_RS41905	COG2197	response regulator
GYK45_RS41910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS41965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GYK45_RS42005	COG1695	Transcriptional regulator
GYK45_RS42030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GYK45_RS42045	COG0789	Transcriptional regulator
GYK45_RS42080	COG0515	serine threonine protein kinase
GYK45_RS42080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GYK45_RS42090	COG0542	response to heat
GYK45_RS42125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYK45_RS42160	COG1942	4-Oxalocrotonate Tautomerase
GYK45_RS42170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GYK45_RS42205	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS42245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GYK45_RS42260	COG0577	efflux transmembrane transporter activity
GYK45_RS42300	COG1609	Transcriptional regulator
GYK45_RS42310	COG0673	inositol 2-dehydrogenase activity
GYK45_RS42315	COG2226	methyltransferase
GYK45_RS42340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS42355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYK45_RS42365	COG0395	ABC-type sugar transport system, permease component
GYK45_RS42370	COG1175	transmembrane transport
GYK45_RS42395	COG3119	arylsulfatase activity
GYK45_RS42400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GYK45_RS42420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GYK45_RS42450	COG0531	amino acid
GYK45_RS42465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GYK45_RS42470	COG2828	Protein conserved in bacteria
GYK45_RS42485	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GYK45_RS42510	COG2197	response regulator
GYK45_RS42520	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS42560	COG1609	Transcriptional regulator
GYK45_RS42590	COG3842	ATPase activity
GYK45_RS42620	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS42625	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS42665	COG2226	methyltransferase
GYK45_RS42670	COG3835	regulator
GYK45_RS42695	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS42710	COG3509	depolymerase
GYK45_RS42740	COG0656	L-ascorbic acid biosynthetic process
GYK45_RS42760	COG0488	(ABC) transporter
GYK45_RS42785	COG1819	glycosyl
GYK45_RS42860	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS42905	COG0435	Glutathione S-transferase
GYK45_RS42950	COG1064	alcohol dehydrogenase
GYK45_RS42970	COG3291	Pkd domain containing protein
GYK45_RS42970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GYK45_RS42975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GYK45_RS42985	COG1309	transcriptional regulator
GYK45_RS43050	COG4221	oxidoreductase activity
GYK45_RS43060	COG1396	sequence-specific DNA binding
GYK45_RS43070	COG0477	Major facilitator Superfamily
GYK45_RS43090	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS43105	COG1902	pentaerythritol trinitrate reductase activity
GYK45_RS43110	COG1968	undecaprenyl-diphosphatase activity
GYK45_RS43120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GYK45_RS43125	COG1414	Transcriptional regulator
GYK45_RS43155	COG2610	gluconate transmembrane transporter activity
GYK45_RS43160	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS43190	COG0583	DNA-binding transcription factor activity
GYK45_RS43195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYK45_RS43200	COG4948	Mandelate Racemase Muconate Lactonizing
GYK45_RS43210	COG1175	transmembrane transport
GYK45_RS43230	COG3537	Alpha-1,2-mannosidase
GYK45_RS43250	COG0477	Major facilitator Superfamily
GYK45_RS43260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GYK45_RS43275	COG3387	PFAM Glycoside hydrolase 15-related
GYK45_RS43305	COG0668	transmembrane transport
GYK45_RS43330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS43355	COG2175	clavaminate synthase activity
GYK45_RS43365	COG0739	heme binding
GYK45_RS43370	COG0018	arginyl-trna synthetase
GYK45_RS43375	COG2508	Transcriptional regulator
GYK45_RS43385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GYK45_RS43400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GYK45_RS43410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GYK45_RS43455	COG0326	Molecular chaperone. Has ATPase activity
GYK45_RS43475	COG0412	Dienelactone hydrolase
GYK45_RS43565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GYK45_RS43570	COG2080	2 iron, 2 sulfur cluster binding
GYK45_RS43575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GYK45_RS43580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS43615	COG0747	negative chemotaxis
GYK45_RS43645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS43650	COG3594	Acyltransferase
GYK45_RS43655	COG2376	Dihydroxyacetone kinase
GYK45_RS43660	COG2376	Dihydroxyacetone kinase
GYK45_RS43665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GYK45_RS43690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GYK45_RS43700	COG4565	transcriptional regulatory protein
GYK45_RS43715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS43720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GYK45_RS43740	COG0726	polysaccharide deacetylase
GYK45_RS43745	COG0114	fumarate hydratase activity
GYK45_RS43775	COG2175	clavaminate synthase activity
GYK45_RS43795	COG0306	phosphate transporter
GYK45_RS43805	COG1357	PFAM Pentapeptide repeats (8 copies)
GYK45_RS43855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GYK45_RS43865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GYK45_RS43905	COG3511	phospholipase C
GYK45_RS43930	COG1051	belongs to the nudix hydrolase family
GYK45_RS43970	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS43975	COG1959	2 iron, 2 sulfur cluster binding
GYK45_RS44005	COG2356	endonuclease I
GYK45_RS44020	COG3321	synthase
GYK45_RS44020	COG0604	alcohol dehydrogenase
GYK45_RS44020	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS44050	COG1309	transcriptional regulator
GYK45_RS44060	COG0596	Alpha beta hydrolase
GYK45_RS44090	COG2124	cytochrome p450
GYK45_RS44105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GYK45_RS44115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GYK45_RS44120	COG2080	2 iron, 2 sulfur cluster binding
GYK45_RS44150	COG1982	Orn Lys Arg decarboxylase major
GYK45_RS44180	COG1309	transcriptional regulator
GYK45_RS44195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS44205	COG0789	Transcriptional regulator
GYK45_RS44215	COG2345	Transcriptional regulator
GYK45_RS44220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GYK45_RS44225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GYK45_RS44225	COG1017	nitric oxide dioxygenase activity
GYK45_RS44230	COG1959	2 iron, 2 sulfur cluster binding
GYK45_RS44260	COG0667	Aldo Keto reductase
GYK45_RS44265	COG2318	DinB family
GYK45_RS44285	COG3622	Belongs to the hyi family
GYK45_RS44290	COG2271	Major facilitator Superfamily
GYK45_RS44295	COG0235	Class ii aldolase
GYK45_RS44300	COG3395	kinase activity
GYK45_RS44305	COG2084	Dehydrogenase
GYK45_RS44315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GYK45_RS44370	COG0739	heme binding
GYK45_RS44395	COG1733	regulation of RNA biosynthetic process
GYK45_RS44425	COG1846	Transcriptional regulator
GYK45_RS44445	COG4977	sequence-specific DNA binding
GYK45_RS44480	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS44480	COG0300	oxidoreductase activity
GYK45_RS44480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GYK45_RS44480	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS44480	COG3321	synthase
GYK45_RS44490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GYK45_RS44500	COG2192	nodulation
GYK45_RS44540	COG1011	Hydrolase
GYK45_RS44565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GYK45_RS44570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GYK45_RS44580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GYK45_RS44585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GYK45_RS44605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GYK45_RS44625	COG3387	PFAM Glycoside hydrolase 15-related
GYK45_RS44665	COG0395	ABC-type sugar transport system, permease component
GYK45_RS44675	COG2197	response regulator
GYK45_RS44690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GYK45_RS44695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GYK45_RS44710	COG2124	cytochrome p450
GYK45_RS44725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GYK45_RS44750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GYK45_RS44765	COG4221	oxidoreductase activity
GYK45_RS44835	COG1595	DNA-templated transcription, initiation
GYK45_RS44855	COG1053	succinate dehydrogenase
GYK45_RS44870	COG1595	DNA-templated transcription, initiation
GYK45_RS44935	COG0477	Major facilitator Superfamily
GYK45_RS45025	COG0109	protoheme IX farnesyltransferase activity
GYK45_RS45030	COG2837	iron assimilation
GYK45_RS45075	COG1309	transcriptional regulator
GYK45_RS45090	COG1609	Transcriptional regulator
GYK45_RS45120	COG1621	beta-fructofuranosidase activity
GYK45_RS45175	COG0395	ABC-type sugar transport system, permease component
GYK45_RS45180	COG1175	transmembrane transport
GYK45_RS45195	COG2186	Transcriptional regulator
GYK45_RS45205	COG0477	Major facilitator Superfamily
GYK45_RS45215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GYK45_RS45295	COG0488	(ABC) transporter
GYK45_RS45350	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS45420	COG0701	Predicted permease
GYK45_RS45430	COG0513	Belongs to the DEAD box helicase family
GYK45_RS45525	COG0038	chloride channel
GYK45_RS45530	COG1846	Transcriptional regulator
GYK45_RS45600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GYK45_RS45610	COG2226	methyltransferase
GYK45_RS45615	COG1228	amidohydrolase
GYK45_RS45660	COG3454	Phosphonate metabolism
GYK45_RS45665	COG1126	abc transporter atp-binding protein
GYK45_RS45670	COG4107	phosphonate C-P lyase system protein PhnK
GYK45_RS45690	COG1073	alpha beta
GYK45_RS45705	COG4977	sequence-specific DNA binding
GYK45_RS45710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GYK45_RS45720	COG0789	Transcriptional regulator
GYK45_RS45725	COG0508	dehydrogenase complex catalyzes the overall conversion of
GYK45_RS45745	COG2186	Transcriptional regulator
GYK45_RS45765	COG0601	transmembrane transport
GYK45_RS45780	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS45785	COG1012	belongs to the aldehyde dehydrogenase family
GYK45_RS45790	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS45805	COG2186	Transcriptional regulator
GYK45_RS45810	COG0142	geranyltranstransferase activity
GYK45_RS45830	COG0655	NAD(P)H dehydrogenase (quinone) activity
GYK45_RS45835	COG3961	Belongs to the TPP enzyme family
GYK45_RS45840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GYK45_RS45860	COG0154	amidase activity
GYK45_RS45885	COG2130	NADP-dependent
GYK45_RS45905	COG1733	regulation of RNA biosynthetic process
GYK45_RS45915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GYK45_RS46000	COG4608	Belongs to the ABC transporter superfamily
GYK45_RS46005	COG0444	Belongs to the ABC transporter superfamily
GYK45_RS46010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GYK45_RS46015	COG0601	transmembrane transport
GYK45_RS46020	COG0747	negative chemotaxis
GYK45_RS46025	COG4221	oxidoreductase activity
GYK45_RS46035	COG1733	regulation of RNA biosynthetic process
GYK45_RS46050	COG2130	NADP-dependent
GYK45_RS46085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GYK45_RS46110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GYK45_RS46130	COG3661	Belongs to the glycosyl hydrolase 67 family
GYK45_RS46145	COG0395	ABC-type sugar transport system, permease component
GYK45_RS46150	COG1175	transmembrane transport
GYK45_RS46190	COG2271	Major facilitator Superfamily
GYK45_RS46195	COG1846	Transcriptional regulator
GYK45_RS46200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GYK45_RS46205	COG1024	Enoyl-CoA hydratase
GYK45_RS46215	COG1024	Enoyl-CoA hydratase
GYK45_RS46220	COG0318	PFAM AMP-dependent synthetase and ligase
GYK45_RS46225	COG2070	2-Nitropropane dioxygenase
GYK45_RS46235	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS46285	COG1309	transcriptional regulator
GYK45_RS46345	COG0477	Major facilitator Superfamily
GYK45_RS46370	COG1335	isochorismatase
GYK45_RS46375	COG0596	Alpha beta hydrolase
GYK45_RS46415	COG1454	alcohol dehydrogenase
GYK45_RS46430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GYK45_RS46455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GYK45_RS46470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GYK45_RS46475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GYK45_RS46480	COG1733	regulation of RNA biosynthetic process
GYK45_RS46495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GYK45_RS46515	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS46545	COG1028	Short-chain dehydrogenase reductase Sdr
GYK45_RS46640	COG2890	protein-(glutamine-N5) methyltransferase activity
GYK45_RS46655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS46660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GYK45_RS46670	COG0667	Aldo Keto reductase
GYK45_RS46715	COG0829	nickel cation binding
GYK45_RS46720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GYK45_RS46735	COG0832	Belongs to the urease beta subunit family
GYK45_RS46745	COG0395	ABC-type sugar transport system, permease component
GYK45_RS46750	COG1611	Belongs to the LOG family
GYK45_RS46760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GYK45_RS46785	COG0561	phosphatase activity
GYK45_RS46835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan