locus-tag class description EJC51_RS00205 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EJC51_RS00215 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJC51_RS00245 ENOG4105DQE DNA ligase EJC51_RS00325 ENOG4105FDF Could be involved in DNA repair (By similarity) EJC51_RS00365 ENOG4105BZU Histidine kinase EJC51_RS00440 ENOG4105PAD Hydrolase EJC51_RS00575 ENOG41062JF Transcriptional regulator EJC51_RS00585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS00595 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EJC51_RS00605 ENOG4105C5X domain protein EJC51_RS00610 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EJC51_RS00625 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS00630 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS00645 ENOG4105CNN ABC, transporter EJC51_RS00650 ENOG4105CNN ABC, transporter EJC51_RS00655 ENOG4105C2J ABC transporter EJC51_RS00705 ENOG4105BZU Histidine kinase EJC51_RS00710 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS00720 ENOG4108KQ5 Integrase catalytic subunit EJC51_RS00750 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS00805 ENOG4105D4K integrase catalytic EJC51_RS00840 ENOG41080RH Thioredoxin EJC51_RS00845 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) EJC51_RS00850 ENOG4105VPX protein, conserved in bacteria EJC51_RS00855 ENOG4108VCT Sulfite exporter TauE/SafE EJC51_RS00860 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EJC51_RS00865 ENOG4107TPS domain protein EJC51_RS00880 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS00965 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EJC51_RS01035 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EJC51_RS01040 ENOG4105JAB phenazine biosynthesis protein, phzf family EJC51_RS01050 ENOG4105WQI isochorismatase EJC51_RS01060 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EJC51_RS01125 ENOG4105W5Z EJC51_RS01145 ENOG4108PC0 lipolytic protein G-D-S-L family EJC51_RS01165 ENOG4105W1Y Transcriptional regulator EJC51_RS01170 ENOG4105EMU Dehydrogenase EJC51_RS01200 ENOG4106A3M Cytochrome p-450 EJC51_RS01275 ENOG4105NAE bifunctional deaminase-reductase domain protein EJC51_RS01320 ENOG4108RU0 short-chain dehydrogenase reductase EJC51_RS01345 ENOG4105CJ1 ABC, transporter EJC51_RS01385 ENOG4107SM8 Adenylate Guanylate cyclase EJC51_RS01415 ENOG4105CHR reductase EJC51_RS01435 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS01445 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJC51_RS01485 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJC51_RS01500 ENOG4108ZHJ Organic hydroperoxide resistance protein EJC51_RS01505 ENOG4108Z4U Ferredoxin EJC51_RS01600 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJC51_RS01630 ENOG4108KPJ rna polymerase sigma factor EJC51_RS01640 ENOG4108KPJ rna polymerase sigma factor EJC51_RS01695 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EJC51_RS01710 ENOG4108KPJ rna polymerase sigma factor EJC51_RS01790 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EJC51_RS01795 ENOG4105CPC Aldo Keto reductase EJC51_RS01805 ENOG4105EMU Dehydrogenase EJC51_RS01840 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EJC51_RS01875 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJC51_RS01895 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS01915 ENOG4105C7W Xanthine dehydrogenase EJC51_RS01920 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding EJC51_RS01925 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit EJC51_RS01940 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJC51_RS01960 ENOG4105CPQ Dehydrogenase EJC51_RS02000 ENOG4105CS1 NAD(P)H quinone oxidoreductase EJC51_RS02010 ENOG4105CPQ Dehydrogenase EJC51_RS02035 ENOG4105CHR reductase EJC51_RS02065 ENOG4105C57 major facilitator superfamily EJC51_RS02085 ENOG4105CUX Signal transduction histidine kinase EJC51_RS02095 ENOG4105E1F short-chain dehydrogenase reductase EJC51_RS02110 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJC51_RS02135 ENOG4105CPQ Dehydrogenase EJC51_RS02155 ENOG4108MYR Secreted protein EJC51_RS02170 ENOG41086D8 Transcriptional regulator EJC51_RS02225 ENOG4107RGH Aldehyde dehydrogenase EJC51_RS02255 ENOG4105E1F short-chain dehydrogenase reductase EJC51_RS02300 ENOG4107JEE Short-chain dehydrogenase reductase Sdr EJC51_RS02310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJC51_RS02320 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJC51_RS02330 ENOG4108IG5 Transcriptional regulator EJC51_RS02340 ENOG4108IG5 Transcriptional regulator EJC51_RS02345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJC51_RS02350 ENOG4105CHR reductase EJC51_RS02370 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJC51_RS02375 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS02390 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EJC51_RS02395 ENOG41067SE Tetr family transcriptional regulator EJC51_RS02400 ENOG4105DYW oxidoreductase EJC51_RS02415 ENOG4105CHR reductase EJC51_RS02425 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS02435 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS02485 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EJC51_RS02490 ENOG4108IND Tetr family transcriptional regulator EJC51_RS02500 ENOG4105C26 Dehydrogenase EJC51_RS02505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJC51_RS02520 ENOG4105C57 major facilitator superfamily EJC51_RS02625 ENOG4105CIR epoxide hydrolase EJC51_RS02710 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) EJC51_RS02715 ENOG4108W8B Beta-lactamase domain protein EJC51_RS02735 ENOG4105C2C drug resistance transporter, Bcr CflA EJC51_RS02760 ENOG4105DSG hydrolase family 43 EJC51_RS02805 ENOG410829K Lysine exporter protein (Lyse ygga) EJC51_RS02820 ENOG41068W2 Cytochrome p-450 EJC51_RS02825 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EJC51_RS02865 ENOG4108X0B nad(p)h dehydrogenase (quinone) EJC51_RS02870 ENOG4105YVS arsR family transcriptional regulator EJC51_RS02875 ENOG4105BZU Histidine kinase EJC51_RS02920 ENOG4105H3G oxidoreductase EJC51_RS02935 ENOG4107S4Y M20 DapE family protein YgeY EJC51_RS02955 ENOG4105EBR Carboxylesterase EJC51_RS02965 ENOG4105D9P serine threonine protein kinase EJC51_RS02975 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJC51_RS02990 ENOG4105E0A ABC, transporter EJC51_RS02995 ENOG4105EHG Permease protein EJC51_RS03065 ENOG41082SX arsR family transcriptional regulator EJC51_RS03070 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS03075 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS03080 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS03115 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EJC51_RS03120 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJC51_RS03125 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJC51_RS03135 ENOG4105C0X amino acid EJC51_RS03210 ENOG4108W5M transcriptional regulator EJC51_RS03220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS03235 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS03250 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EJC51_RS03255 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS03260 ENOG4105KVH Transcriptional regulator EJC51_RS03285 ENOG4105C57 major facilitator superfamily EJC51_RS03310 ENOG4105KTE polyketide synthesis cyclase EJC51_RS03315 ENOG4108Y5I Cyclase dehydrase EJC51_RS03320 ENOG41079R3 acyl carrier protein EJC51_RS03335 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein EJC51_RS03400 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS03410 ENOG41086KC Transcriptional regulator EJC51_RS03495 ENOG4107U9B transcriptional regulator EJC51_RS03510 ENOG4108UHU Aldolase EJC51_RS03515 ENOG4105CHR reductase EJC51_RS03520 ENOG4105CPQ Dehydrogenase EJC51_RS03535 ENOG4105DIA mandelate racemase muconate lactonizing EJC51_RS03540 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EJC51_RS03545 ENOG4105C2J ABC transporter EJC51_RS03585 ENOG4105C7F AcnD-accessory protein PrpF EJC51_RS03605 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS03620 ENOG4105EX0 alpha-galactosidase EJC51_RS03625 ENOG4106R7G Glycoside hydrolase family 5 EJC51_RS03640 ENOG4107S5I aldo keto reductase EJC51_RS03670 ENOG4105KVH Transcriptional regulator EJC51_RS03680 ENOG4108JDX DNA polymerase iii, epsilon subunit EJC51_RS03700 ENOG4105BZU Histidine kinase EJC51_RS03705 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS03720 ENOG4108MTT Glutamate-rich protein grpB EJC51_RS03745 ENOG4105XEA Tetr family transcriptional regulator EJC51_RS03765 ENOG4106F60 Histidine kinase EJC51_RS03785 ENOG4105CPF Cell wall formation (By similarity) EJC51_RS03790 ENOG4108UQS dipeptidase EJC51_RS03795 ENOG4105C5Q Transcriptional regulator EJC51_RS03820 ENOG4108638 50S ribosomal protein L36 EJC51_RS03825 ENOG4105NRA 50s ribosomal protein l31 type b EJC51_RS03845 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) EJC51_RS03875 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS03885 ENOG4107ZHV Transcriptional regulator EJC51_RS03960 ENOG4105C1J atp-dependent rna helicase EJC51_RS03980 ENOG4105EYF MMPL domain protein EJC51_RS03985 ENOG4105BZU Histidine kinase EJC51_RS03990 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS03995 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS04005 ENOG4105DRS transport system, permease EJC51_RS04015 ENOG4105C4C beta-galactosidase EJC51_RS04040 ENOG4105GRZ Ycii-related protein EJC51_RS04045 ENOG4105CHP RNA polymerase EJC51_RS04055 ENOG4105NAE bifunctional deaminase-reductase domain protein EJC51_RS04065 ENOG4106JUT Streptomycin 3''-adenylyltransferase EJC51_RS04070 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS04080 ENOG4105D8K carboxyl transferase EJC51_RS04085 ENOG4107RCI amp-dependent synthetase and ligase EJC51_RS04090 ENOG4107EEY synthase EJC51_RS04140 ENOG4105F44 Two component transcriptional regulator, winged helix family EJC51_RS04145 ENOG4106F60 Histidine kinase EJC51_RS04160 ENOG4105C7B Threonine dehydratase EJC51_RS04165 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS04195 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EJC51_RS04210 ENOG4105EXW epimerase dehydratase EJC51_RS04220 ENOG4106FGB Beta-lactamase EJC51_RS04270 ENOG4108YIQ Alpha beta hydrolase EJC51_RS04290 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EJC51_RS04315 ENOG4108ZT1 Transcriptional regulator EJC51_RS04320 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EJC51_RS04325 ENOG4108N5B 2-phosphosulfolactate phosphatase EJC51_RS04345 ENOG4108Z4X TRANSCRIPTIONal EJC51_RS04350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJC51_RS04355 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJC51_RS04360 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJC51_RS04385 ENOG41082MF Hydrogenase assembly chaperone hypC hupF EJC51_RS04400 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EJC51_RS04415 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJC51_RS04420 ENOG4105CQS hydrogenase expression formation protein HypD EJC51_RS04480 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) EJC51_RS04500 ENOG4107WUB V-type ATPase 116 kDa subunit EJC51_RS04520 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJC51_RS04525 ENOG4107VEG TrkA-N domain protein EJC51_RS04570 ENOG4105CIG ABC transporter EJC51_RS04575 ENOG4105EIE fructose-bisphosphate aldolase EJC51_RS04585 ENOG41080XP Cbs domain EJC51_RS04600 ENOG4108Z0T Part of a sulfur-relay system (By similarity) EJC51_RS04635 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EJC51_RS04640 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EJC51_RS04645 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EJC51_RS04650 ENOG4105E2A Dehydrogenase EJC51_RS04665 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJC51_RS04670 ENOG4105CD5 CoA-binding domain protein EJC51_RS04725 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJC51_RS04745 ENOG4105CJ1 ABC, transporter EJC51_RS04770 ENOG4107UVD Beta-phosphoglucomutase family hydrolase EJC51_RS04795 ENOG4105CY0 Metallo-Beta-Lactamase EJC51_RS04800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJC51_RS04810 ENOG4105EJ5 oxidoreductase gamma subunit EJC51_RS04815 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EJC51_RS04820 ENOG4105DDK oxidoreductase, beta subunit EJC51_RS04825 ENOG4105BZ8 glutamate synthase EJC51_RS04835 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJC51_RS04855 ENOG4105CHR reductase EJC51_RS04865 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJC51_RS04875 ENOG410880H cysteine synthase EJC51_RS04880 ENOG4107S8C mandelate racemase muconate lactonizing EJC51_RS04900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJC51_RS04905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS04935 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EJC51_RS04960 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands EJC51_RS04985 ENOG4108YYC ycei family EJC51_RS04995 ENOG4105CSR polyphosphate kinase 2 EJC51_RS05010 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJC51_RS05015 ENOG4105BZU Histidine kinase EJC51_RS05060 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJC51_RS05120 ENOG41067TZ transcriptional regulator, MarR family EJC51_RS05130 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EJC51_RS05155 ENOG4105EYF MMPL domain protein EJC51_RS05180 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS05185 ENOG4105BZU Histidine kinase EJC51_RS05190 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS05195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJC51_RS05205 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJC51_RS05235 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS05280 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJC51_RS05305 ENOG4107RTD sua5 ycio yrdc ywlc family protein EJC51_RS05330 ENOG4108IAJ Nad-dependent epimerase dehydratase EJC51_RS05340 ENOG4105BZU Histidine kinase EJC51_RS05360 ENOG4105CAT Cytidine monophosphate kinase EJC51_RS05365 ENOG4108HKT sucrose-6-phosphate hydrolase EJC51_RS05375 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS05380 ENOG4105DRS transport system, permease EJC51_RS05425 ENOG4105R1U AraC Family Transcriptional Regulator EJC51_RS05430 ENOG4105EU0 Major facilitator Superfamily EJC51_RS05455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJC51_RS05460 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) EJC51_RS05475 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EJC51_RS05500 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS05530 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) EJC51_RS05540 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) EJC51_RS05545 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJC51_RS05550 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) EJC51_RS05565 ENOG4105CEP NADH dehydrogenase EJC51_RS05575 ENOG4108TM9 integral membrane protein EJC51_RS05595 ENOG4105CXN decarboxylase EJC51_RS05605 ENOG4105E8G Major facilitator Superfamily EJC51_RS05635 ENOG4105BZU Histidine kinase EJC51_RS05675 ENOG4105C5X domain protein EJC51_RS05695 ENOG4105C3M thioredoxin reductase EJC51_RS05700 ENOG4105CUX Signal transduction histidine kinase EJC51_RS05710 ENOG4107SM8 Adenylate Guanylate cyclase EJC51_RS05725 ENOG4105EX0 alpha-galactosidase EJC51_RS05730 ENOG4105E2R ROK family EJC51_RS05745 ENOG4105K4I Scp-like extracellular EJC51_RS05765 ENOG4105C7B Threonine dehydratase EJC51_RS05770 ENOG4107QPV Serine Threonine protein kinase EJC51_RS05780 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJC51_RS05790 ENOG4105KF0 sporulation and cell division protein, SsgA EJC51_RS05795 ENOG4108R5S membrane EJC51_RS05805 ENOG4105CPC Aldo Keto reductase EJC51_RS05820 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS05840 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJC51_RS05850 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJC51_RS05855 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS05870 ENOG4105BZU Histidine kinase EJC51_RS05885 ENOG4105CIR epoxide hydrolase EJC51_RS05890 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJC51_RS05895 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJC51_RS05910 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS05940 ENOG4105IDI abc transporter atp-binding protein EJC51_RS05960 ENOG4105CPC Aldo Keto reductase EJC51_RS05965 ENOG4108M0I Transcriptional regulator EJC51_RS05980 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJC51_RS05985 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase EJC51_RS05995 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) EJC51_RS06000 ENOG4107S5I aldo keto reductase EJC51_RS06005 ENOG4107QRI Phosphoketolase EJC51_RS06010 ENOG4105C26 Dehydrogenase EJC51_RS06030 ENOG4105C32 Amino acid ABC transporter (Permease) EJC51_RS06040 ENOG4105C0Z ABC transporter EJC51_RS06045 ENOG4108IV0 ABC, transporter EJC51_RS06050 ENOG4105CHP RNA polymerase EJC51_RS06075 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EJC51_RS06095 ENOG4105FBW Monooxygenase EJC51_RS06105 ENOG4105DZ2 Transcriptional regulator EJC51_RS06115 ENOG4105CGD Nad-dependent epimerase dehydratase EJC51_RS06120 ENOG4105CVP deoxyribo-dipyrimidine photolyase EJC51_RS06140 ENOG41082BM Transcriptional regulator, arsr family EJC51_RS06185 ENOG4105BZU Histidine kinase EJC51_RS06215 ENOG4105CEU Arginine dihydrolase EJC51_RS06220 ENOG4105D5Q Arginine ornithine antiporter EJC51_RS06270 ENOG4107SM8 Adenylate Guanylate cyclase EJC51_RS06305 ENOG4105E39 Enoyl-CoA hydratase EJC51_RS06325 ENOG4108J2P Alpha beta hydrolase fold EJC51_RS06340 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS06400 ENOG4107S1E Beta-lactamase EJC51_RS06425 ENOG4105D9P serine threonine protein kinase EJC51_RS06445 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EJC51_RS06450 ENOG4105X7H acyl-CoA dehydrogenase EJC51_RS06485 ENOG4105EBR Carboxylesterase EJC51_RS06490 ENOG4105EGE secreted protein EJC51_RS06495 ENOG4105CMT Dihydroxyacetone kinase EJC51_RS06500 ENOG4108UTZ Dihydroxyacetone kinase EJC51_RS06505 ENOG4105VDH Dihydroxyacetone kinase EJC51_RS06515 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJC51_RS06540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJC51_RS06565 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJC51_RS06605 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS06610 ENOG4105I82 acetyl xylan esterase EJC51_RS06625 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) EJC51_RS06640 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJC51_RS06650 ENOG4105DZ1 carboxypeptidase EJC51_RS06660 ENOG41090CE integral membrane protein EJC51_RS06665 ENOG4105CSV Glutaminase EJC51_RS06670 ENOG4108IJ0 Aspartate ammonia-lyase EJC51_RS06685 ENOG41073TP transcriptional regulator EJC51_RS06690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJC51_RS06700 ENOG4105KJJ Uncharacterized ACR, COG1993 EJC51_RS06735 ENOG4105D56 permease protein EJC51_RS06745 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS06770 ENOG4108KC1 acyl-Coa dehydrogenase EJC51_RS06780 ENOG4105EC3 peptidase S51, dipeptidase E EJC51_RS06800 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EJC51_RS06805 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EJC51_RS06865 ENOG4107QQG Dehydrogenase EJC51_RS06870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJC51_RS06920 ENOG4107QJZ Glycosyl transferase, family 2 EJC51_RS06945 ENOG4105C1B dTDP-glucose 4-6-dehydratase EJC51_RS06955 ENOG4105D3Q Sugar transferase EJC51_RS07080 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EJC51_RS07085 ENOG4107R8N Glycosyl transferase, family 2 EJC51_RS07120 ENOG4105MVE transcriptional regulator EJC51_RS07145 ENOG4105EJQ L-serine dehydratase EJC51_RS07150 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJC51_RS07160 ENOG4105EEI dihydropteroate synthase EJC51_RS07180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJC51_RS07195 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component EJC51_RS07200 ENOG4108IJ7 Glycine betaine EJC51_RS07220 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EJC51_RS07230 ENOG4105DVW rieske (2Fe-2S) EJC51_RS07235 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase EJC51_RS07255 ENOG4107R34 abc transporter permease protein EJC51_RS07260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS07290 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJC51_RS07295 ENOG4105EMY transcriptional regulator EJC51_RS07300 ENOG4108YZG isomerase EJC51_RS07305 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJC51_RS07315 ENOG4105DKQ ROK family EJC51_RS07325 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) EJC51_RS07330 ENOG4105D2N Aldolase EJC51_RS07335 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJC51_RS07340 ENOG4105E98 transcriptional regulator DeoR family EJC51_RS07345 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS07355 ENOG4105E93 esterase EJC51_RS07360 ENOG4105BZ1 (ABC) transporter EJC51_RS07370 ENOG4105BZ1 (ABC) transporter EJC51_RS07375 ENOG4105J76 Periplasmic binding protein EJC51_RS07380 ENOG4105E0A ABC, transporter EJC51_RS07385 ENOG4105TVJ transport system, permease EJC51_RS07390 ENOG4105DQ5 transport system permease protein EJC51_RS07450 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS07455 ENOG4108TGC Acyltransferase EJC51_RS07475 ENOG4106T9R serine protease EJC51_RS07495 ENOG4108YYC ycei family EJC51_RS07505 ENOG4107W6X Transcriptional regulator EJC51_RS07525 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EJC51_RS07560 ENOG4108UYE Lactoylglutathione lyase EJC51_RS07565 ENOG4108I0C methyltransferase EJC51_RS07570 ENOG4106UW1 Major Facilitator superfamily EJC51_RS07590 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS07595 ENOG4105BZU Histidine kinase EJC51_RS07600 ENOG4107R13 MMPL domain protein EJC51_RS07620 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EJC51_RS07625 ENOG4107PP3 Acetylornithine deacetylase EJC51_RS07635 ENOG4105I1F Resistance protein EJC51_RS07645 ENOG4105ECP epimerase EJC51_RS07650 ENOG4105EX0 alpha-galactosidase EJC51_RS07660 ENOG41060NJ transcriptional regulator EJC51_RS07670 ENOG4107TPY serine threonine protein kinase EJC51_RS07685 ENOG4105C10 Electron transfer flavoprotein EJC51_RS07710 ENOG4105E9Q Acyl-transferase EJC51_RS07750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJC51_RS07770 ENOG4105CPC Aldo Keto reductase EJC51_RS07795 ENOG410841Q phosphoesterase PA-phosphatase related protein EJC51_RS07830 ENOG4105C2W permease EJC51_RS07835 ENOG4105YVS arsR family transcriptional regulator EJC51_RS07840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJC51_RS07845 ENOG4107S46 esterase, PHB depolymerase EJC51_RS07860 ENOG4105CSU acyl-Coa dehydrogenase EJC51_RS07880 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EJC51_RS07885 ENOG4105RD7 BadF BadG BcrA BcrD EJC51_RS07895 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJC51_RS07910 ENOG4107VXZ Hydrolase EJC51_RS07920 ENOG4107SM8 Adenylate Guanylate cyclase EJC51_RS07925 ENOG4105CHR reductase EJC51_RS07965 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EJC51_RS07970 ENOG4106A3M Cytochrome p-450 EJC51_RS08000 ENOG4107GJV short-chain dehydrogenase reductase EJC51_RS08005 ENOG4105CSH Transporter EJC51_RS08020 ENOG41065SU Two-component system sensor kinase EJC51_RS08025 ENOG4108KXV response regulator EJC51_RS08040 ENOG4105CHH sulfate transporter EJC51_RS08045 ENOG4106NMR serine protease EJC51_RS08050 ENOG4108RNG Permease of the drug metabolite transporter EJC51_RS08060 ENOG4107ZED Uncharacterised protein family UPF0047 EJC51_RS08065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJC51_RS08070 ENOG4105E2Y ABC, transporter EJC51_RS08080 ENOG4105H3G oxidoreductase EJC51_RS08090 ENOG4105BZ1 (ABC) transporter EJC51_RS08095 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJC51_RS08100 ENOG4105CK2 sodium dicarboxylate symporter EJC51_RS08115 ENOG4105BZ1 (ABC) transporter EJC51_RS08120 ENOG4105BZ1 (ABC) transporter EJC51_RS08160 ENOG4105C29 acyl-CoA thioesterase EJC51_RS08170 ENOG4105GWZ Roadblock lc7 family protein EJC51_RS08195 ENOG4105BZU Histidine kinase EJC51_RS08240 ENOG4105C0D helicase EJC51_RS08260 ENOG4105C93 Xylose Isomerase EJC51_RS08275 ENOG4107SCA Formamidase (EC 3.5.1.49) EJC51_RS08285 ENOG4107RR1 TRANSCRIPTIONal EJC51_RS08290 ENOG4105C26 Dehydrogenase EJC51_RS08320 ENOG4108SC4 )-transporter EJC51_RS08340 ENOG41061H0 Monooxygenase EJC51_RS08355 ENOG4105ERH Fumarylacetoacetate hydrolase EJC51_RS08375 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase EJC51_RS08395 ENOG4105K56 Transcriptional regulator EJC51_RS08425 ENOG4105D2B acyl-CoA dehydrogenase EJC51_RS08430 ENOG4105D2B acyl-CoA dehydrogenase EJC51_RS08435 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJC51_RS08445 ENOG4105C3M thioredoxin reductase EJC51_RS08450 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) EJC51_RS08460 ENOG4105C26 Dehydrogenase EJC51_RS08470 ENOG41065KQ synthase EJC51_RS08475 ENOG4106A3M Cytochrome p-450 EJC51_RS08485 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS08495 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJC51_RS08505 ENOG4105F1K Glutamine amidotransferase EJC51_RS08510 ENOG4105CTQ phosphohexokinase EJC51_RS08535 ENOG4108HRK Histidine kinase EJC51_RS08550 ENOG4108NEV two component transcriptional regulator, LytTR family EJC51_RS08560 ENOG4105CIK Amidinotransferase EJC51_RS08565 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS08590 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) EJC51_RS08600 ENOG4105CQM Urea amidohydrolase subunit alpha EJC51_RS08605 ENOG4105KI2 Urea amidohydrolase subunit beta EJC51_RS08610 ENOG4108YZ9 Urea amidohydrolase subunit gamma EJC51_RS08615 ENOG4108Q5F Tetr family transcriptional regulator EJC51_RS08660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EJC51_RS08665 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EJC51_RS08670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJC51_RS08675 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EJC51_RS08700 ENOG4107SK7 Sarcosine-dimethylglycine methyltransferase EJC51_RS08715 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS08720 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS08730 ENOG4108R6G acetyltransferase EJC51_RS08750 ENOG4105C83 adenylosuccinate lyase EJC51_RS08755 ENOG4108VCA G U mismatch-specific DNA glycosylase EJC51_RS08775 ENOG4105BZU Histidine kinase EJC51_RS08780 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS08785 ENOG4105DKQ ROK family EJC51_RS08790 ENOG4105FDP GntR family transcriptional regulator EJC51_RS08795 ENOG4108KPJ rna polymerase sigma factor EJC51_RS08810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS08850 ENOG4108PSK reductase EJC51_RS08870 ENOG4105EYH Exonuclease EJC51_RS08875 ENOG4107RH8 nuclease SbcCD subunit D EJC51_RS08880 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EJC51_RS08900 ENOG4105K4P CoA-binding domain protein EJC51_RS09005 ENOG41082SX arsR family transcriptional regulator EJC51_RS09030 ENOG4108UW5 maltose o-acetyltransferase EJC51_RS09035 ENOG4108Z0R Transferase EJC51_RS09045 ENOG4105EBR Carboxylesterase EJC51_RS09050 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJC51_RS09080 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EJC51_RS09095 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS09105 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 EJC51_RS09125 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJC51_RS09150 ENOG4105MSY salicylate hydroxylase EJC51_RS09160 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EJC51_RS09165 ENOG4105EP9 oxidoreductase EJC51_RS09185 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EJC51_RS09195 ENOG4105CHR reductase EJC51_RS09230 ENOG4106P55 Transcriptional regulator EJC51_RS09235 ENOG4108Q5Y Membrane EJC51_RS09240 ENOG4105CSW GntR family transcriptional regulator EJC51_RS09290 ENOG4106IPI cyclase, family EJC51_RS09295 ENOG4107TIF Phenazine biosynthesis protein, PhzF family EJC51_RS09325 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS09350 ENOG4105DSG hydrolase family 43 EJC51_RS09360 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EJC51_RS09365 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJC51_RS09370 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EJC51_RS09395 ENOG4105F4R Transcriptional regulator mode EJC51_RS09400 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EJC51_RS09430 ENOG4108UW8 fha domain-containing protein EJC51_RS09480 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EJC51_RS09490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJC51_RS09505 ENOG4108UQS dipeptidase EJC51_RS09515 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJC51_RS09520 ENOG4105BZU Histidine kinase EJC51_RS09525 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJC51_RS09530 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJC51_RS09580 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EJC51_RS09590 ENOG4105CFM UPF0317 protein EJC51_RS09595 ENOG4105E7W lamb ycsf family protein EJC51_RS09600 ENOG4105P4J Allophanate hydrolase, subunit 1 EJC51_RS09610 ENOG41090WU lipolytic protein G-D-S-L family EJC51_RS09615 ENOG4108MJN Glycosyl Transferase EJC51_RS09635 ENOG4105JXB ankyrin repeat-containing protein EJC51_RS09650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS09655 ENOG4108VW9 Membrane EJC51_RS09665 ENOG4105DEU major facilitator superfamily EJC51_RS09670 ENOG4105Q70 EJC51_RS09680 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) EJC51_RS09690 ENOG4105EW9 transcriptional regulator AsnC family EJC51_RS09715 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS09765 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EJC51_RS09770 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase EJC51_RS09775 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EJC51_RS09780 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EJC51_RS09795 ENOG4105E2R ROK family EJC51_RS09810 ENOG4105C2W permease EJC51_RS09850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS09870 ENOG4108TZY GntR Family Transcriptional Regulator EJC51_RS09880 ENOG4105CUB amino acid EJC51_RS09900 ENOG4105DKT Transcriptional regulator EJC51_RS09905 ENOG4105DJV ribulose-phosphate 3-epimerase EJC51_RS09910 ENOG4105EYF MMPL domain protein EJC51_RS09920 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EJC51_RS09935 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EJC51_RS09950 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EJC51_RS09960 ENOG4105SKN orotidine 5''-phosphate decarboxylase EJC51_RS09965 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EJC51_RS09970 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJC51_RS09975 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EJC51_RS09985 ENOG4105CD3 dihydroorotase EJC51_RS09990 ENOG4105CXT aspartate transcarbamylase EJC51_RS09995 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EJC51_RS10005 ENOG410803B Involved in the transcription termination process (By similarity) EJC51_RS10010 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EJC51_RS10015 ENOG4105DC7 peptidase M24 EJC51_RS10025 ENOG4105D49 3-dehydroquinate synthase EJC51_RS10030 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EJC51_RS10035 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EJC51_RS10040 ENOG4105E2X shikimate dehydrogenase EJC51_RS10045 ENOG4105HHA aminodeoxychorismate lyase EJC51_RS10055 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EJC51_RS10060 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EJC51_RS10080 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EJC51_RS10105 ENOG4105CUT histidyl-tRNA synthetase EJC51_RS10115 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) EJC51_RS10120 ENOG4105C99 atpase involved in dna repair EJC51_RS10125 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJC51_RS10135 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EJC51_RS10140 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJC51_RS10145 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EJC51_RS10155 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EJC51_RS10160 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EJC51_RS10165 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EJC51_RS10170 ENOG4105CDY transcriptional regulatory protein EJC51_RS10175 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EJC51_RS10180 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EJC51_RS10190 ENOG4105E2K Glycosyl transferase (Group 1 EJC51_RS10195 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase EJC51_RS10225 ENOG4105C22 threonyL-tRNA synthetase EJC51_RS10240 ENOG4108JDX DNA polymerase iii, epsilon subunit EJC51_RS10260 ENOG4105EKC EJC51_RS10270 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJC51_RS10275 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EJC51_RS10280 ENOG410769Z extracellular solute-binding protein family 1 EJC51_RS10295 ENOG4105KF0 sporulation and cell division protein, SsgA EJC51_RS10320 ENOG4105F0I Aminotransferase EJC51_RS10325 ENOG4105CRQ synthase (Component I) EJC51_RS10385 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJC51_RS10390 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EJC51_RS10405 ENOG4105D01 (LipO)protein EJC51_RS10410 ENOG4105D01 (LipO)protein EJC51_RS10415 ENOG4108UMI ABC transporter, permease EJC51_RS10420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS10425 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 EJC51_RS10455 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS10460 ENOG4105C57 major facilitator superfamily EJC51_RS10465 ENOG4105RJZ Transcriptional regulator EJC51_RS10475 ENOG4105CH7 arginosuccinase EJC51_RS10495 ENOG4105BZU Histidine kinase EJC51_RS10500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS10505 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJC51_RS10530 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EJC51_RS10535 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS10540 ENOG4105CAS nag kinase EJC51_RS10545 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EJC51_RS10550 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EJC51_RS10580 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJC51_RS10590 ENOG4105T38 integral membrane protein EJC51_RS10600 ENOG4105F32 YngK protein EJC51_RS10630 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJC51_RS10635 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EJC51_RS10640 ENOG4105BZU Histidine kinase EJC51_RS10645 ENOG4108RWN rrna methyltransferase EJC51_RS10650 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EJC51_RS10655 ENOG41084BS 50S ribosomal protein L35 EJC51_RS10660 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EJC51_RS10705 ENOG4105C26 Dehydrogenase EJC51_RS10710 ENOG4105C5F glutamine synthetase EJC51_RS10720 ENOG4108Z86 Glutamine amidotransferase EJC51_RS10740 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EJC51_RS10750 ENOG4108HQS Glycine betaine EJC51_RS10755 ENOG4108IJ7 Glycine betaine EJC51_RS10765 ENOG4105HFS 5'-3' exonuclease EJC51_RS10795 ENOG4105D3G Pseudouridine synthase EJC51_RS10800 ENOG4106A3M Cytochrome p-450 EJC51_RS10860 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EJC51_RS10865 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EJC51_RS10895 ENOG4108V1T peptidylprolyl cis-trans isomerase EJC51_RS10900 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) EJC51_RS10910 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS10915 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) EJC51_RS10920 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) EJC51_RS10930 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) EJC51_RS10935 ENOG4105E5F proteasome EJC51_RS10940 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) EJC51_RS10970 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS10975 ENOG4108J59 Extracellular solute-binding protein, family 5 EJC51_RS10980 ENOG4105DEF Extracellular solute-binding protein, family 5 EJC51_RS10985 ENOG4107URF beta-phospho-glucomutase EJC51_RS10990 ENOG4105C3R Methionine synthase EJC51_RS10995 ENOG4108K8U Glycerol operon regulatory protein EJC51_RS11000 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJC51_RS11005 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJC51_RS11010 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJC51_RS11020 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EJC51_RS11030 ENOG4105C2J ABC transporter EJC51_RS11040 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EJC51_RS11045 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) EJC51_RS11055 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EJC51_RS11065 ENOG4108JQ9 ABC transporter EJC51_RS11070 ENOG4105UIB (ABC) transporter EJC51_RS11085 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS11090 ENOG4105JXH GntR family transcriptional regulator EJC51_RS11115 ENOG4105C8N cysteinyl-tRNA synthetase EJC51_RS11130 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJC51_RS11135 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS11145 ENOG4105DYW oxidoreductase EJC51_RS11150 ENOG4105CPC Aldo Keto reductase EJC51_RS11170 ENOG4105S2J secreted protein EJC51_RS11180 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJC51_RS11195 ENOG4105CD8 aminopeptidase N EJC51_RS11200 ENOG4105K5B UPF0225 protein EJC51_RS11205 ENOG4107EJG GntR family transcriptional regulator EJC51_RS11210 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EJC51_RS11215 ENOG4105C6Z Gluconate EJC51_RS11250 ENOG4105PTV Nudix Hydrolase EJC51_RS11260 ENOG4105VG5 Membrane EJC51_RS11270 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJC51_RS11285 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS11290 ENOG4105DUM transcriptional regulator, lysR family EJC51_RS11295 ENOG4108IG5 Transcriptional regulator EJC51_RS11300 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS11310 ENOG4105EHZ conserved protein UCP016719 EJC51_RS11345 ENOG4108Z4X TRANSCRIPTIONal EJC51_RS11365 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS11375 ENOG4108ZHR arsR family transcriptional regulator EJC51_RS11380 ENOG4107Y9U Membrane EJC51_RS11415 ENOG4105D4T Citrate transporter EJC51_RS11420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJC51_RS11425 ENOG4108SGK Tetr family transcriptional regulator EJC51_RS11435 ENOG4105F1J Homogentisate 1,2-dioxygenase EJC51_RS11470 ENOG4105RNG membrane EJC51_RS11475 ENOG4105K6V RNA polymerase EJC51_RS11485 ENOG4105EJG cellulose synthase EJC51_RS11490 ENOG41061MD high-affinity nickel-transporter EJC51_RS11500 ENOG4108TCJ secreted hydrolase EJC51_RS11505 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS11530 ENOG4107BJW polysaccharide deacetylase EJC51_RS11555 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS11580 ENOG4108EKC n-acetylglutamate synthase EJC51_RS11605 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EJC51_RS11610 ENOG4105C0B DNA polymerase III (alpha subunit) EJC51_RS11630 ENOG4106NMR serine protease EJC51_RS11685 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EJC51_RS11690 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS11695 ENOG4105C57 major facilitator superfamily EJC51_RS11705 ENOG410841Q phosphoesterase PA-phosphatase related protein EJC51_RS11745 ENOG4105C0Z ABC transporter EJC51_RS11750 ENOG4108IV0 ABC, transporter EJC51_RS11760 ENOG4105MS9 Resuscitation-promoting factor EJC51_RS11775 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EJC51_RS11785 ENOG4105CAT Cytidine monophosphate kinase EJC51_RS11850 ENOG4105FE9 pseudouridine synthase EJC51_RS11855 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EJC51_RS11860 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EJC51_RS11875 ENOG4105DCF alanine dehydrogenase EJC51_RS11885 ENOG4108YZ4 nudix hydrolase EJC51_RS11890 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJC51_RS11895 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS11910 ENOG4107RJ7 Glycosyl transferase (Group 1 EJC51_RS11915 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EJC51_RS11920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EJC51_RS11940 ENOG4105E0A ABC, transporter EJC51_RS11945 ENOG4105TVJ transport system, permease EJC51_RS11950 ENOG4105DQ5 transport system permease protein EJC51_RS11955 ENOG4105DSU hydrolase EJC51_RS11995 ENOG4108VX5 3-methyladenine DNA glycosylase EJC51_RS12005 ENOG4108V1U phospholipid-binding protein EJC51_RS12025 ENOG4105DKW ABC transporter EJC51_RS12045 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS12055 ENOG4105EMU Dehydrogenase EJC51_RS12070 ENOG4105IDI abc transporter atp-binding protein EJC51_RS12085 ENOG4105EAC phosphoserine phosphatase EJC51_RS12110 ENOG4107YCY Transcriptional regulator EJC51_RS12120 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EJC51_RS12125 ENOG4105CHR reductase EJC51_RS12140 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJC51_RS12160 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJC51_RS12165 ENOG4107QN1 sodium solute EJC51_RS12180 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS12190 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F EJC51_RS12200 ENOG4105E2A Dehydrogenase EJC51_RS12230 ENOG4105E0T Short-chain dehydrogenase reductase Sdr EJC51_RS12250 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJC51_RS12265 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS12295 ENOG4105VBF alkaline shock protein EJC51_RS12305 ENOG41060WC Enoyl-CoA hydratase EJC51_RS12315 ENOG4105C5H ABC transporter EJC51_RS12340 ENOG4107W7X Aldolase EJC51_RS12360 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) EJC51_RS12365 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EJC51_RS12370 ENOG4105CTK cobaltochelatase, cobn subunit EJC51_RS12380 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EJC51_RS12385 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EJC51_RS12400 ENOG4105CIA precorrin-4 C(11)-methyltransferase EJC51_RS12410 ENOG4105E4R Precorrin-3B C17-methyltransferase EJC51_RS12415 ENOG41081F0 Precorrin-8x methylmutase EJC51_RS12420 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJC51_RS12440 ENOG4105CDA abc transporter atp-binding protein EJC51_RS12445 ENOG4105EAD ABC transporter EJC51_RS12450 ENOG4106PMH Extracellular solute-binding protein family 3 EJC51_RS12455 ENOG4105C5R Aminotransferase EJC51_RS12465 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase EJC51_RS12470 ENOG4108JPW Aminotransferase EJC51_RS12475 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) EJC51_RS12480 ENOG4105EV8 ectoine hydroxylase EJC51_RS12485 ENOG4105C9B Cysteine desulfurase EJC51_RS12515 ENOG4107HP6 Transcriptional regulator EJC51_RS12530 ENOG4105C7N Xanthine uracil vitamin C permease EJC51_RS12535 ENOG4105NAF rna polymerase sigma factor EJC51_RS12560 ENOG4105NBR Pectinesterase EJC51_RS12565 ENOG4105NBR Pectinesterase EJC51_RS12570 ENOG4108J20 pectate lyase EJC51_RS12575 ENOG4107TDE lipolytic protein G-D-S-L family EJC51_RS12585 ENOG4105E4I Glycoside hydrolase family 28 EJC51_RS12605 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS12615 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EJC51_RS12620 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS12645 ENOG4105E9Z Nad-dependent epimerase dehydratase EJC51_RS12650 ENOG4105E98 transcriptional regulator DeoR family EJC51_RS12665 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EJC51_RS12670 ENOG4105CPQ Dehydrogenase EJC51_RS12700 ENOG4107XBN GntR Family Transcriptional Regulator EJC51_RS12745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJC51_RS12755 ENOG4105NAF rna polymerase sigma factor EJC51_RS12770 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) EJC51_RS12785 ENOG4108RFG Tetr family transcriptional regulator EJC51_RS12790 ENOG410814C multidrug resistance protein EJC51_RS12800 ENOG4105VG1 fes assembly suf system protein EJC51_RS12805 ENOG4108UNV SUF system FeS assembly protein, NifU family EJC51_RS12810 ENOG4105C9B Cysteine desulfurase EJC51_RS12815 ENOG4105C3K feS assembly ATPase SufC EJC51_RS12825 ENOG4105JRK feS assembly protein SufD EJC51_RS12840 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EJC51_RS12845 ENOG4105CJ1 ABC, transporter EJC51_RS12875 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EJC51_RS12890 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJC51_RS12905 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) EJC51_RS12915 ENOG4107QP8 phosphohexose isomerase EJC51_RS12935 ENOG4105CP7 Triose-phosphate isomerase EJC51_RS12940 ENOG4105BZA Phosphoglycerate kinase EJC51_RS12945 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJC51_RS12955 ENOG4105CIE May be required for sporulation (By similarity) EJC51_RS12960 ENOG4105CHW UPF0052 protein EJC51_RS12965 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EJC51_RS12970 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJC51_RS12990 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS13000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJC51_RS13010 ENOG4107VMB Beta-lactamase domain protein EJC51_RS13015 ENOG4107R0W ABC transporter EJC51_RS13020 ENOG4105E5Q amino acid AbC transporter EJC51_RS13030 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EJC51_RS13035 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJC51_RS13040 ENOG4105CSH Transporter EJC51_RS13070 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EJC51_RS13075 ENOG4105BZU Histidine kinase EJC51_RS13080 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJC51_RS13085 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJC51_RS13090 ENOG4105E2A Dehydrogenase EJC51_RS13100 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EJC51_RS13110 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJC51_RS13115 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS13140 ENOG4108RYK Nad-dependent epimerase dehydratase EJC51_RS13160 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS13165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS13170 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJC51_RS13205 ENOG4105BZ1 (ABC) transporter EJC51_RS13220 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS13240 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS13265 ENOG4108762 serine threonine protein kinase EJC51_RS13270 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EJC51_RS13310 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EJC51_RS13350 ENOG41088T4 Helicase IV EJC51_RS13375 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJC51_RS13385 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EJC51_RS13390 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS13410 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJC51_RS13430 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EJC51_RS13440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EJC51_RS13445 ENOG4108YRB methyltransferase EJC51_RS13455 ENOG4105CQ7 ATP-dependent helicase EJC51_RS13495 ENOG4105KA0 thioesterase Superfamily protein EJC51_RS13515 ENOG4105C32 Amino acid ABC transporter (Permease) EJC51_RS13520 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EJC51_RS13525 ENOG4105C0Z ABC transporter EJC51_RS13530 ENOG4108IV0 ABC, transporter EJC51_RS13560 ENOG4105CGH 5'-nucleotidase EJC51_RS13580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS13585 ENOG4105EHE chorismate mutase- prephenate dehydrogenase EJC51_RS13610 ENOG410834F Transcriptional regulator EJC51_RS13625 ENOG4105E39 Enoyl-CoA hydratase EJC51_RS13640 ENOG4105EA8 2-Nitropropane dioxygenase EJC51_RS13645 ENOG4105F2C Acetyl-CoA acetyltransferase EJC51_RS13650 ENOG4108RZE Tetr family transcriptional regulator EJC51_RS13655 ENOG4105CHR reductase EJC51_RS13660 ENOG4105CC9 acyl-Coa dehydrogenase EJC51_RS13665 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS13670 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJC51_RS13680 ENOG4107S5I aldo keto reductase EJC51_RS13685 ENOG4105MUA Resistance protein EJC51_RS13715 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJC51_RS13730 ENOG4105CBC glutamate synthase EJC51_RS13740 ENOG41065RQ ADP-ribosylation crystallin J1 EJC51_RS13765 ENOG4108RVA ribokinase EJC51_RS13770 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJC51_RS13780 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EJC51_RS13790 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EJC51_RS13795 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EJC51_RS13805 ENOG4105DK0 Indole-3-glycerol phosphate synthase EJC51_RS13825 ENOG4105CRQ synthase (Component I) EJC51_RS13830 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EJC51_RS13850 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EJC51_RS13855 ENOG4108176 endoribonuclease L-psp EJC51_RS13860 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EJC51_RS13865 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EJC51_RS13870 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EJC51_RS13875 ENOG4105CIH Imidazole acetol-phosphate transaminase EJC51_RS13880 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EJC51_RS13900 ENOG4108Z66 YbaK ebsC protein EJC51_RS13925 ENOG4105C0B DNA polymerase III (alpha subunit) EJC51_RS13985 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EJC51_RS14000 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EJC51_RS14005 ENOG4107VQS DivIVA family EJC51_RS14015 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EJC51_RS14020 ENOG4105DFA alanine racemase domain protein EJC51_RS14025 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EJC51_RS14030 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EJC51_RS14035 ENOG4105ME9 cell division protein FtsQ EJC51_RS14040 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJC51_RS14050 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EJC51_RS14055 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EJC51_RS14065 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJC51_RS14070 ENOG4105CJN penicillin-binding protein EJC51_RS14080 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EJC51_RS14090 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJC51_RS14110 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJC51_RS14120 ENOG4105CDA abc transporter atp-binding protein EJC51_RS14130 ENOG4107Z3H Transcriptional regulator, TetR family EJC51_RS14140 ENOG4107VFM Dehydrogenase EJC51_RS14155 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EJC51_RS14185 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EJC51_RS14195 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EJC51_RS14210 ENOG4108UQY Iron-storage protein EJC51_RS14220 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase EJC51_RS14235 ENOG4105C5I Dehydrogenase EJC51_RS14240 ENOG4105CTQ phosphohexokinase EJC51_RS14245 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS14250 ENOG4105ENE Histidine kinase EJC51_RS14275 ENOG4105DKQ ROK family EJC51_RS14285 ENOG4105D0U Arsenite-activated ATPase (ArsA) EJC51_RS14320 ENOG4105UQX Mate efflux family protein EJC51_RS14365 ENOG4108762 serine threonine protein kinase EJC51_RS14370 ENOG4105C9B Cysteine desulfurase EJC51_RS14375 ENOG4108I0Q anthranilate phosphoribosyltransferase EJC51_RS14380 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJC51_RS14385 ENOG4107EUI c reductase, iron-sulfur EJC51_RS14390 ENOG4107UDY cytochrome C EJC51_RS14395 ENOG4105CCU oxidase (Subunit III) EJC51_RS14405 ENOG4107UBC ErfK ybiS ycfS ynhG family protein EJC51_RS14410 ENOG4105MCD Part of cytochrome c oxidase, its function is EJC51_RS14415 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJC51_RS14420 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EJC51_RS14430 ENOG4107T4Z adenosine kinase EJC51_RS14450 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EJC51_RS14455 ENOG4108762 serine threonine protein kinase EJC51_RS14465 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS14470 ENOG4105BZU Histidine kinase EJC51_RS14490 ENOG4105DXX methyltransferase EJC51_RS14495 ENOG4105C0H protease EJC51_RS14505 ENOG4108YZT Adenosylcobinamide kinase EJC51_RS14515 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EJC51_RS14520 ENOG4105CRK lysyL-tRNA synthetase EJC51_RS14555 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS14565 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EJC51_RS14590 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EJC51_RS14635 ENOG4105ECP epimerase EJC51_RS14650 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EJC51_RS14655 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EJC51_RS14675 ENOG4105C5F glutamine synthetase EJC51_RS14690 ENOG4105D0M Protease HtpX homolog EJC51_RS14725 ENOG4108222 arsenate reductase EJC51_RS14735 ENOG4106SPC secreted protein EJC51_RS14750 ENOG4107R5B glutamine synthetase EJC51_RS14760 ENOG4107NHD transcriptional regulator EJC51_RS14770 ENOG4108XG2 Histidine kinase EJC51_RS14775 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS14810 ENOG41060BG Tetr family transcriptional regulator EJC51_RS14840 ENOG4105CG3 alpha amylase, catalytic region EJC51_RS14845 ENOG4105EG2 ABC transporter, permease EJC51_RS14850 ENOG4105D56 permease protein EJC51_RS14860 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS14870 ENOG4107RSM transcriptional regulator EJC51_RS14875 ENOG4105FDR Membrane EJC51_RS14880 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EJC51_RS14895 ENOG4105FBN Acid phosphatase EJC51_RS14910 ENOG4105C5F glutamine synthetase EJC51_RS14935 ENOG4105F27 Major Facilitator EJC51_RS14950 ENOG4105C57 major facilitator superfamily EJC51_RS14955 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EJC51_RS14975 ENOG4107XZ0 Peptidase M50 EJC51_RS15020 ENOG410650H (LipO)protein EJC51_RS15025 ENOG4105DBE peroxidase EJC51_RS15035 ENOG4106A0S EJC51_RS15055 ENOG4107S1E Beta-lactamase EJC51_RS15060 ENOG4105C2C drug resistance transporter, Bcr CflA EJC51_RS15070 ENOG4105DGI Alkaline phosphatase EJC51_RS15085 ENOG4105C19 ABC transporter EJC51_RS15095 ENOG4108VGI doxx family EJC51_RS15130 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EJC51_RS15145 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJC51_RS15160 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EJC51_RS15175 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS15220 ENOG4108JA1 polyketide synthase EJC51_RS15275 ENOG4105E7U AraC family transcriptional regulator EJC51_RS15295 ENOG4107XFJ UPF0246 protein EJC51_RS15300 ENOG4108UHU Aldolase EJC51_RS15315 ENOG4105EGD dinuclear metal center protein, YbgI family EJC51_RS15325 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr EJC51_RS15340 ENOG4105BZU Histidine kinase EJC51_RS15345 ENOG4108S01 response regulator EJC51_RS15355 ENOG4105KVH Transcriptional regulator EJC51_RS15395 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase EJC51_RS15405 ENOG4105DYW oxidoreductase EJC51_RS15425 ENOG4107QVI Methyltransferase, type 11 EJC51_RS15430 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS15435 ENOG4108SGK Tetr family transcriptional regulator EJC51_RS15485 ENOG4108JJB ABC transporter EJC51_RS15500 ENOG4105XPP Protein of unknown function (DUF1275) EJC51_RS15525 ENOG4105F2C Acetyl-CoA acetyltransferase EJC51_RS15530 ENOG4106A3M Cytochrome p-450 EJC51_RS15535 ENOG4105H3G oxidoreductase EJC51_RS15545 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS15610 ENOG4107VXZ Hydrolase EJC51_RS15650 ENOG4105E8R UPF0173 metal-dependent hydrolase EJC51_RS15655 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJC51_RS15695 ENOG4105DAX Pfam:DUF2983 EJC51_RS15740 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EJC51_RS15745 ENOG4105EYW Ion transport protein EJC51_RS15780 ENOG4105CPC Aldo Keto reductase EJC51_RS15785 ENOG4105VUF Transcriptional regulator EJC51_RS15820 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJC51_RS15840 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EJC51_RS15845 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJC51_RS15860 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJC51_RS15865 ENOG4106KR7 LysR family Transcriptional regulator EJC51_RS15870 ENOG4105NGS secreted protein EJC51_RS15875 ENOG4105N14 lysine exporter protein LysE YggA EJC51_RS15880 ENOG4105EXN Sulfate transport protein CysZ EJC51_RS15900 ENOG4108ZHJ Organic hydroperoxide resistance protein EJC51_RS15905 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EJC51_RS15925 ENOG41062B0 ABC transporter, permease EJC51_RS15930 ENOG4107R9N ABC transporter EJC51_RS15935 ENOG4105C2J ABC transporter EJC51_RS15940 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EJC51_RS15945 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS15950 ENOG4105CXK mandelate racemase muconate lactonizing EJC51_RS15965 ENOG4105DFW ABC transporter EJC51_RS15975 ENOG4108HWW ABC transporter EJC51_RS15980 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EJC51_RS15985 ENOG4105CIH Imidazole acetol-phosphate transaminase EJC51_RS16005 ENOG410626B catechol 1,2-dioxygenase EJC51_RS16055 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EJC51_RS16060 ENOG4105J4Q Transcriptional regulator EJC51_RS16095 ENOG41073B4 coagulation factor 5 8 type domain-containing protein EJC51_RS16140 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS16145 ENOG4105D8K carboxyl transferase EJC51_RS16185 ENOG41062D9 Histidine kinase EJC51_RS16190 ENOG4105ETX regulatoR EJC51_RS16220 ENOG4105BZU Histidine kinase EJC51_RS16225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS16265 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS16270 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EJC51_RS16280 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EJC51_RS16290 ENOG4107GZ4 SanA protein EJC51_RS16310 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJC51_RS16340 ENOG4105C57 major facilitator superfamily EJC51_RS16385 ENOG4107QZF nitrite reductase NADPH large subunit EJC51_RS16395 ENOG4108IND Tetr family transcriptional regulator EJC51_RS16400 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJC51_RS16430 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJC51_RS16435 ENOG4105E2R ROK family EJC51_RS16490 ENOG4108FN7 Aldo keto reductase EJC51_RS16495 ENOG410829K Lysine exporter protein (Lyse ygga) EJC51_RS16500 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) EJC51_RS16510 ENOG4105FDK ABC transporter EJC51_RS16515 ENOG4105FAV ABC, transporter EJC51_RS16535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJC51_RS16540 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) EJC51_RS16595 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS16600 ENOG4105BZU Histidine kinase EJC51_RS16605 ENOG4105EYF MMPL domain protein EJC51_RS16615 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EJC51_RS16625 ENOG4105D4Y metalloprotease EJC51_RS16655 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJC51_RS16740 ENOG4105MSB protein, conserved in bacteria EJC51_RS16750 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EJC51_RS16770 ENOG4105EQX glucarate dehydratase EJC51_RS16775 ENOG4107HP6 Transcriptional regulator EJC51_RS16790 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EJC51_RS16795 ENOG4107YU2 histidine triad (hIT) protein EJC51_RS16800 ENOG4107RE3 peptidase, S41 EJC51_RS16820 ENOG4107QWG 2-Nitropropane dioxygenase EJC51_RS16825 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EJC51_RS16830 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EJC51_RS16855 ENOG4105DBE peroxidase EJC51_RS16870 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein EJC51_RS16880 ENOG4105BZU Histidine kinase EJC51_RS16885 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJC51_RS16895 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EJC51_RS16900 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EJC51_RS16925 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EJC51_RS16930 ENOG4105KQC Competence protein EJC51_RS16935 ENOG4105EPR degv family EJC51_RS16945 ENOG4105C8T Leucyl-tRNA synthetase EJC51_RS16960 ENOG4107QIZ NADH dehydrogenase EJC51_RS16995 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJC51_RS17010 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EJC51_RS17015 ENOG4105D0M Protease HtpX homolog EJC51_RS17030 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EJC51_RS17040 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EJC51_RS17075 ENOG4105DGI Alkaline phosphatase EJC51_RS17095 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EJC51_RS17100 ENOG4105K46 50S ribosomal protein l27 EJC51_RS17105 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EJC51_RS17120 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EJC51_RS17130 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EJC51_RS17135 ENOG4105C03 ribonuclease EJC51_RS17190 ENOG4105CNI cell division protein FtsW EJC51_RS17210 ENOG4105DFF Rod shape-determining protein mreb EJC51_RS17215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EJC51_RS17225 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EJC51_RS17230 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EJC51_RS17240 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EJC51_RS17245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJC51_RS17250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJC51_RS17255 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EJC51_RS17290 ENOG4108TGC Acyltransferase EJC51_RS17305 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS17325 ENOG4108YZG isomerase EJC51_RS17330 ENOG4105C85 amino acid EJC51_RS17335 ENOG4108UGD Serine Threonine protein kinase EJC51_RS17355 ENOG4105E2R ROK family EJC51_RS17365 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJC51_RS17370 ENOG4105E2Y ABC, transporter EJC51_RS17385 ENOG4105C85 amino acid EJC51_RS17390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJC51_RS17400 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJC51_RS17405 ENOG4105CMG Carbohydrate kinase EJC51_RS17410 ENOG4105E98 transcriptional regulator DeoR family EJC51_RS17420 ENOG4105CMG Carbohydrate kinase EJC51_RS17430 ENOG4105MC2 DSBA oxidoreductase EJC51_RS17485 ENOG4108UYE Lactoylglutathione lyase EJC51_RS17495 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS17530 ENOG4105EVZ LysR family transcriptional regulator EJC51_RS17540 ENOG4108KTG Membrane protein, drug metabolite transporter EJC51_RS17545 ENOG4108ZT1 Transcriptional regulator EJC51_RS17550 ENOG4107SCK Monooxygenase EJC51_RS17580 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS17595 ENOG4105D8X mechanosensitive ion channel EJC51_RS17620 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component EJC51_RS17625 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJC51_RS17630 ENOG4105F8D glycoside hydrolase family 4 EJC51_RS17645 ENOG4105CT1 (ABC) transporter EJC51_RS17675 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EJC51_RS17695 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS17725 ENOG4105VHU single-stranded DNA-binding protein EJC51_RS17765 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EJC51_RS17790 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EJC51_RS17800 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EJC51_RS17815 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJC51_RS17845 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS17885 ENOG4108R96 Methyltransferase, YaeB family EJC51_RS17895 ENOG4107U2T alpha beta EJC51_RS17915 ENOG4105VJY transcriptional regulator EJC51_RS17950 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EJC51_RS17980 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EJC51_RS18090 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJC51_RS18120 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS18230 ENOG4105C12 Phosphoribosylglycinamide synthetase EJC51_RS18310 ENOG4105Z8B NlpC/P60 family EJC51_RS18415 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJC51_RS18540 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJC51_RS18555 ENOG4105C3J Cysteine desulfurase EJC51_RS18560 ENOG4105CFI type iii restriction protein res subunit EJC51_RS18615 ENOG4105C5S asparaginyl-tRNA synthetase EJC51_RS18710 ENOG4105CJR Integral membrane protein (MviN EJC51_RS18720 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS18745 ENOG4105C3M thioredoxin reductase EJC51_RS18750 ENOG4105S2J secreted protein EJC51_RS18815 ENOG4105C26 Dehydrogenase EJC51_RS18820 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EJC51_RS18825 ENOG4105DH8 myo-inositol catabolism EJC51_RS18835 ENOG4105EDK PfkB domain protein EJC51_RS18840 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EJC51_RS18860 ENOG4105CPQ Dehydrogenase EJC51_RS18885 ENOG4105C7H Helicase, RecD TraA family EJC51_RS18910 ENOG4108JCI Transcriptional regulator EJC51_RS18915 ENOG4108Z7F N-acetyltransferase EJC51_RS18925 ENOG4105C2J ABC transporter EJC51_RS18930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJC51_RS18935 ENOG4108RVA ribokinase EJC51_RS18940 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EJC51_RS18970 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS18995 ENOG410645S MarR family Transcriptional regulator EJC51_RS19025 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EJC51_RS19030 ENOG4108594 Permease of the drug metabolite transporter EJC51_RS19045 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJC51_RS19085 ENOG4105EDW glycosyl transferase, family 39 EJC51_RS19090 ENOG4108K8S endonuclease I EJC51_RS19095 ENOG4105C7K acetolactate synthase EJC51_RS19105 ENOG4105CK7 Sodium proline symporter EJC51_RS19115 ENOG4108XFF EJC51_RS19125 ENOG4105C29 acyl-CoA thioesterase EJC51_RS19140 ENOG4107QX3 carboxylase EJC51_RS19150 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EJC51_RS19155 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS19165 ENOG4105CNA YD repeat protein EJC51_RS19205 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) EJC51_RS19215 ENOG4105DUU IucA IucC family protein EJC51_RS19220 ENOG4105E2D ec 3.2.1.52 EJC51_RS19240 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJC51_RS19260 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS19265 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EJC51_RS19280 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS19295 ENOG4105DRS transport system, permease EJC51_RS19305 ENOG4108NNZ chitinase EJC51_RS19310 ENOG410804D Sensor Signal Transduction Histidine Kinase EJC51_RS19340 ENOG4108ZM9 phosphoglycerate mutase EJC51_RS19385 ENOG4105BZU Histidine kinase EJC51_RS19390 ENOG4105DEN Luciferase family EJC51_RS19415 ENOG4105DV0 amidase (EC 3.5.1.4 EJC51_RS19455 ENOG4105J5T Amp-dependent synthetase and ligase EJC51_RS19465 ENOG4108M1A Chitin-binding protein EJC51_RS19495 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJC51_RS19530 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component EJC51_RS19535 ENOG4108MP3 ABC transporter, permease EJC51_RS19540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS19550 ENOG4105MWK D-amino acid dehydrogenase, small subunit EJC51_RS19555 ENOG41080U6 GntR family transcriptional regulator EJC51_RS19570 ENOG4105D9R oxidoreductase EJC51_RS19575 ENOG41090KN UPF0303 protein EJC51_RS19585 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJC51_RS19605 ENOG4108U4N (sortase) family EJC51_RS19735 ENOG4107QNK )-transporter EJC51_RS19740 ENOG4106BRA Membrane EJC51_RS19755 ENOG4108IUW ABC transporter EJC51_RS19770 ENOG4108JQC penicillin-binding protein 1A EJC51_RS19805 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EJC51_RS19815 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EJC51_RS19835 ENOG4108RQ5 Beta-lactamase domain-containing protein EJC51_RS19860 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS19870 ENOG4105C85 amino acid EJC51_RS19885 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EJC51_RS19895 ENOG4108RWI nicotinamidase EJC51_RS19925 ENOG4105KF0 sporulation and cell division protein, SsgA EJC51_RS19930 ENOG4105CQB FAD linked oxidase domain protein EJC51_RS19960 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJC51_RS19970 ENOG4105E90 ABC transporter EJC51_RS19975 ENOG4108IJ8 ABC transporter EJC51_RS19980 ENOG4105E90 ABC transporter EJC51_RS20015 ENOG41086VY Fic/DOC family EJC51_RS20060 ENOG4105E2D ec 3.2.1.52 EJC51_RS20090 ENOG4108UJU UPF0301 protein EJC51_RS20095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJC51_RS20100 ENOG4108426 dNA-binding protein EJC51_RS20110 ENOG4105EEM helicase EJC51_RS20140 ENOG4105DQQ Major facilitator superfamily MFS_1 EJC51_RS20220 ENOG4105VMP Transcriptional regulator EJC51_RS20260 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS20270 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJC51_RS20275 ENOG4105BZ7 extracellular solute-binding protein family 1 EJC51_RS20290 ENOG4105CJQ hydrolase, family 31 EJC51_RS20295 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS20305 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EJC51_RS20325 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EJC51_RS20330 ENOG4105CN1 protease EJC51_RS20340 ENOG4105CAK Cell division ATP-binding protein ftsE EJC51_RS20355 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EJC51_RS20360 ENOG4108QVN serine threonine protein kinase EJC51_RS20365 ENOG4108UGD Serine Threonine protein kinase EJC51_RS20375 ENOG4105EPJ extracellular solute-binding protein family 1 EJC51_RS20385 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EJC51_RS20390 ENOG4107SJB teichoic acid biosynthesis EJC51_RS20395 ENOG4108ZHJ Organic hydroperoxide resistance protein EJC51_RS20400 ENOG4105K56 Transcriptional regulator EJC51_RS20430 ENOG4105EY8 ABC transporter EJC51_RS20440 ENOG4105C7I Dehydrogenase EJC51_RS20465 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EJC51_RS20475 ENOG4105T0Z Conserved Protein EJC51_RS20480 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS20485 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea EJC51_RS20495 ENOG4105G3P Lipoprotein lpqB EJC51_RS20500 ENOG4105BZU Histidine kinase EJC51_RS20505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS20595 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EJC51_RS20610 ENOG4108WQ6 secreted protein EJC51_RS20615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJC51_RS20660 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EJC51_RS20665 ENOG4105DM4 PTS System EJC51_RS20670 ENOG4107QYR Signal peptidase i EJC51_RS20680 ENOG4105EIP mannose-6-phosphate isomerase EJC51_RS20690 ENOG4105W49 UPF0434 protein EJC51_RS20715 ENOG4107RGC Glycosyl transferase, family 2 EJC51_RS20720 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS20735 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) EJC51_RS20745 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EJC51_RS20760 ENOG4108KGH TRANSCRIPTIONal EJC51_RS20765 ENOG4108KGH TRANSCRIPTIONal EJC51_RS20770 ENOG4107TB5 TRANSCRIPTIONal EJC51_RS20775 ENOG4108KGH TRANSCRIPTIONal EJC51_RS20800 ENOG4108KGH TRANSCRIPTIONal EJC51_RS20815 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJC51_RS20840 ENOG4107SWG transcriptional regulator MERR family EJC51_RS20845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJC51_RS20855 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EJC51_RS20870 ENOG41065SU Two-component system sensor kinase EJC51_RS20875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS20880 ENOG4105DUX Transporter EJC51_RS20905 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EJC51_RS20920 ENOG41082AN stage II sporulation protein EJC51_RS20925 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS20930 ENOG4105CI2 imidazolone-5-propionate hydrolase EJC51_RS20945 ENOG4105CGP Urocanate hydratase EJC51_RS20990 ENOG4108IJ8 ABC transporter EJC51_RS20995 ENOG4105R40 Glycine betaine carnitine choline EJC51_RS21000 ENOG4105E90 ABC transporter EJC51_RS21010 ENOG4108V9Q carbonic anhydrase EJC51_RS21020 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EJC51_RS21040 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS21085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS21090 ENOG4107RBB ABC transporter, permease EJC51_RS21095 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EJC51_RS21100 ENOG4105CEP NADH dehydrogenase EJC51_RS21120 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EJC51_RS21140 ENOG4106A3M Cytochrome p-450 EJC51_RS21220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS21225 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS21230 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS21245 ENOG4107QN1 sodium solute EJC51_RS21280 ENOG4105BZU Histidine kinase EJC51_RS21295 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EJC51_RS21300 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EJC51_RS21305 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EJC51_RS21310 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EJC51_RS21325 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EJC51_RS21335 ENOG41067SE Tetr family transcriptional regulator EJC51_RS21350 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJC51_RS21355 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJC51_RS21360 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS21390 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EJC51_RS21430 ENOG4105C5H ABC transporter EJC51_RS21445 ENOG4105BZU Histidine kinase EJC51_RS21450 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EJC51_RS21460 ENOG41069ER domain protein EJC51_RS21465 ENOG4105F8V Hydrolase, tatD family EJC51_RS21500 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) EJC51_RS21510 ENOG4108JJB ABC transporter EJC51_RS21515 ENOG4105K56 Transcriptional regulator EJC51_RS21520 ENOG4108ZHJ Organic hydroperoxide resistance protein EJC51_RS21545 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJC51_RS21555 ENOG4105EYF MMPL domain protein EJC51_RS21570 ENOG4108BAS reductase EJC51_RS21575 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJC51_RS21580 ENOG4105F95 Monooxygenase EJC51_RS21585 ENOG4107SWG transcriptional regulator MERR family EJC51_RS21590 ENOG4105CGK Exodeoxyribonuclease III EJC51_RS21600 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS21610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS21630 ENOG4108Z9I -acetyltransferase EJC51_RS21635 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJC51_RS21640 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJC51_RS21650 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJC51_RS21655 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase EJC51_RS21685 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) EJC51_RS21695 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EJC51_RS21705 ENOG4105F1A Pyruvate formate-lyase EJC51_RS21720 ENOG4105KXX peptidase s58 dmpa EJC51_RS21725 ENOG4105FF0 ErfK YbiS YcfS YnhG EJC51_RS21740 ENOG4105DM4 PTS System EJC51_RS21750 ENOG410804X Transcriptional regulator EJC51_RS21775 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EJC51_RS21800 ENOG4107HP6 Transcriptional regulator EJC51_RS21810 ENOG4105DFW ABC transporter EJC51_RS21835 ENOG4107T94 Endo-14-beta-xylanase EJC51_RS21890 ENOG4108V06 Glutathione peroxidase EJC51_RS21905 ENOG4105DZ1 carboxypeptidase EJC51_RS21990 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EJC51_RS22045 ENOG4107R13 MMPL domain protein EJC51_RS22055 ENOG4106PGW Short-chain dehydrogenase reductase Sdr EJC51_RS22060 ENOG4107SET aldo keto reductase EJC51_RS22065 ENOG4105EQ0 Major Facilitator superfamily EJC51_RS22070 ENOG4106A3M Cytochrome p-450 EJC51_RS22095 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EJC51_RS22110 ENOG4105K4T epimerase EJC51_RS22160 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS22180 ENOG4108762 serine threonine protein kinase EJC51_RS22190 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) EJC51_RS22195 ENOG4108ZRZ Transcriptional regulator (AsnC family) EJC51_RS22200 ENOG4105N14 lysine exporter protein LysE YggA EJC51_RS22210 ENOG4105D2B acyl-CoA dehydrogenase EJC51_RS22225 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EJC51_RS22230 ENOG4105D9U N-acetyltransferase EJC51_RS22245 ENOG4105H3G oxidoreductase EJC51_RS22260 ENOG4105CGU Enoyl-CoA hydratase EJC51_RS22280 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS22290 ENOG4107QPD alcohol dehydrogenase EJC51_RS22295 ENOG4105CC9 acyl-Coa dehydrogenase EJC51_RS22320 ENOG4105D2B acyl-CoA dehydrogenase EJC51_RS22325 ENOG4105CC9 acyl-Coa dehydrogenase EJC51_RS22335 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS22345 ENOG41082AN stage II sporulation protein EJC51_RS22400 ENOG4108XEP Alpha Beta Hydrolase Fold protein EJC51_RS22410 ENOG4108SU4 UPF0309 protein EJC51_RS22425 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS22455 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EJC51_RS22470 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS22485 ENOG4107QX3 carboxylase EJC51_RS22515 ENOG4105CQB FAD linked oxidase domain protein EJC51_RS22540 ENOG4106A3M Cytochrome p-450 EJC51_RS22550 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EJC51_RS22565 ENOG4105KVH Transcriptional regulator EJC51_RS22570 ENOG4106JDR secreted EJC51_RS22575 ENOG4106R7G Glycoside hydrolase family 5 EJC51_RS22615 ENOG4105CPC Aldo Keto reductase EJC51_RS22645 ENOG4105C7N Xanthine uracil vitamin C permease EJC51_RS22655 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EJC51_RS22690 ENOG4108N0W Major Facilitator superfamily EJC51_RS22700 ENOG4108UIH futalosine nucleosidase EJC51_RS22705 ENOG4105E63 Pfam:DUF178 EJC51_RS22710 ENOG4105VEQ Cold shock protein EJC51_RS22740 ENOG4105CFI type iii restriction protein res subunit EJC51_RS22750 ENOG4105EEM helicase EJC51_RS22755 ENOG4106N3A copper homeostasis protein cutc EJC51_RS22770 ENOG4105KNA -acetyltransferase EJC51_RS22785 ENOG4105QEK Transcriptional regulator EJC51_RS22790 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EJC51_RS22795 ENOG4105C5Y PTS System EJC51_RS22830 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EJC51_RS22840 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EJC51_RS22845 ENOG4105VEQ Cold shock protein EJC51_RS22860 ENOG4105C3Q Glycosyl transferase, family 2 EJC51_RS22890 ENOG4105CE4 GlcNAc 6-P deacetylase EJC51_RS22905 ENOG4105BZU Histidine kinase EJC51_RS22920 ENOG4108KPJ rna polymerase sigma factor EJC51_RS22925 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) EJC51_RS23025 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS23035 ENOG4105BZ1 (ABC) transporter EJC51_RS23045 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS23050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS23085 ENOG4106F60 Histidine kinase EJC51_RS23090 ENOG4105F44 Two component transcriptional regulator, winged helix family EJC51_RS23095 ENOG4105F44 Two component transcriptional regulator, winged helix family EJC51_RS23125 ENOG4105C2N RNA methyltransferase TrmH family group 3 EJC51_RS23130 ENOG4105C8N cysteinyl-tRNA synthetase EJC51_RS23135 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EJC51_RS23140 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EJC51_RS23145 ENOG4108VJ1 Transcriptional regulator (CarD family EJC51_RS23165 ENOG4105BZU Histidine kinase EJC51_RS23185 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EJC51_RS23190 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJC51_RS23210 ENOG4106AXJ AraC family transcriptional regulator EJC51_RS23225 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS23230 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EJC51_RS23260 ENOG4105DXX methyltransferase EJC51_RS23315 ENOG4105HHS UPF0256 protein EJC51_RS23325 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EJC51_RS23335 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EJC51_RS23340 ENOG41090R7 Ferric uptake EJC51_RS23345 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands EJC51_RS23385 ENOG4105PKJ carbohydrate binding EJC51_RS23390 ENOG4105KHC sulfurtransferase EJC51_RS23415 ENOG4107NHD transcriptional regulator EJC51_RS23420 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS23425 ENOG4105C0H protease EJC51_RS23430 ENOG4105ETX regulatoR EJC51_RS23450 ENOG4105CGH 5'-nucleotidase EJC51_RS23455 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJC51_RS23470 ENOG4105CIG ABC transporter EJC51_RS23485 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS23490 ENOG4105CZV ABC transporter EJC51_RS23510 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EJC51_RS23540 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS23545 ENOG4105CJ3 phosphate transporter EJC51_RS23555 ENOG4105VPX protein, conserved in bacteria EJC51_RS23570 ENOG4105DNP FAD linked oxidase domain protein EJC51_RS23575 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJC51_RS23580 ENOG4105E4C Lytic transglycosylase catalytic EJC51_RS23590 ENOG4107FW0 short-chain dehydrogenase reductase EJC51_RS23715 ENOG4105D5U fad dependent oxidoreductase EJC51_RS23720 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EJC51_RS23730 ENOG4105CPC Aldo Keto reductase EJC51_RS23760 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) EJC51_RS23830 ENOG4105CQ7 ATP-dependent helicase EJC51_RS23850 ENOG4108TAC EJC51_RS23865 ENOG4105CXB phosphoribosylaminoimidazole synthetase EJC51_RS23885 ENOG4108JGH Tetr family transcriptional regulator EJC51_RS23895 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EJC51_RS23900 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EJC51_RS23905 ENOG410839H phosphoribosylformylglycinamidine synthase EJC51_RS23950 ENOG4105C8V SAICAR synthetase EJC51_RS23965 ENOG4105C12 Phosphoribosylglycinamide synthetase EJC51_RS24000 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 EJC51_RS24010 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EJC51_RS24050 ENOG4105D7A ATP-binding protein EJC51_RS24065 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EJC51_RS24080 ENOG4108Z6B deaminase EJC51_RS24090 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein EJC51_RS24095 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS24100 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS24115 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EJC51_RS24120 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS24130 ENOG410905P Pyridoxamine 5-phosphate EJC51_RS24140 ENOG4105C57 major facilitator superfamily EJC51_RS24145 ENOG4105EDW glycosyl transferase, family 39 EJC51_RS24155 ENOG4105BZU Histidine kinase EJC51_RS24160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS24165 ENOG4105KAC Antibiotic biosynthesis monooxygenase EJC51_RS24220 ENOG4108UXN response regulator EJC51_RS24225 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS24230 ENOG4105NAF rna polymerase sigma factor EJC51_RS24270 ENOG4105C0H protease EJC51_RS24285 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EJC51_RS24305 ENOG4107T6F Xaa-Pro aminopeptidase EJC51_RS24310 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS24320 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EJC51_RS24360 ENOG4105DBE peroxidase EJC51_RS24365 ENOG4105CQC Prephenate dehydratase EJC51_RS24370 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EJC51_RS24375 ENOG410667J hydrolase EJC51_RS24410 ENOG4105DA5 (ABC) transporter EJC51_RS24425 ENOG4107SWG transcriptional regulator MERR family EJC51_RS24430 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) EJC51_RS24445 ENOG4105DQF Hydrolase EJC51_RS24450 ENOG4105DR5 peptidase EJC51_RS24460 ENOG4108JJ9 ABC, transporter EJC51_RS24465 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJC51_RS24470 ENOG4105C4M (Ubiquinol oxidase) subunit I EJC51_RS24480 ENOG4105CIH Imidazole acetol-phosphate transaminase EJC51_RS24485 ENOG4107P2S Transcriptional regulator EJC51_RS24505 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EJC51_RS24515 ENOG4105KF0 sporulation and cell division protein, SsgA EJC51_RS24530 ENOG4106048 Cupin 2, conserved barrel domain protein EJC51_RS24535 ENOG41082T9 Membrane EJC51_RS24540 ENOG4105KJF protein tyrosine phosphatase EJC51_RS24545 ENOG4105C28 cystathionine EJC51_RS24575 ENOG4105F27 Major Facilitator EJC51_RS24580 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) EJC51_RS24595 ENOG4105CDU Replicative dna helicase EJC51_RS24605 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EJC51_RS24610 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EJC51_RS24615 ENOG4107YH6 single-stranded DNA-binding protein EJC51_RS24620 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) EJC51_RS24645 ENOG4105BZ4 penicillin-binding protein EJC51_RS24670 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EJC51_RS24685 ENOG4105D9P serine threonine protein kinase EJC51_RS24700 ENOG4105C3M thioredoxin reductase EJC51_RS24705 ENOG4105K63 Thioredoxin EJC51_RS24720 ENOG4107QJE Chromosome Partitioning Protein EJC51_RS24725 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EJC51_RS24735 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJC51_RS24740 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EJC51_RS24745 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EJC51_RS24755 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EJC51_RS24765 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJC51_RS24770 ENOG4108J5G 6-phosphogluconate dehydrogenase EJC51_RS24775 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EJC51_RS24780 ENOG4105K7N UPF0232 protein EJC51_RS24785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJC51_RS24790 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJC51_RS24805 ENOG4108HMN Caspase domain EJC51_RS24830 ENOG4108UGD Serine Threonine protein kinase EJC51_RS24845 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJC51_RS24855 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EJC51_RS24880 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) EJC51_RS24885 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS24895 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EJC51_RS24900 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EJC51_RS24930 ENOG4105ZJT Cell division protein CrgA EJC51_RS24940 ENOG4108U4N (sortase) family EJC51_RS24955 ENOG4108U4N (sortase) family EJC51_RS24960 ENOG4108RN7 integral membrane protein EJC51_RS24980 ENOG4105CJN penicillin-binding protein EJC51_RS24995 ENOG4105HZM Fha domain containing protein EJC51_RS25000 ENOG4105TV9 FHA Domain-Containing protein EJC51_RS25010 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EJC51_RS25015 ENOG4105KVH Transcriptional regulator EJC51_RS25030 ENOG41085GJ domain protein EJC51_RS25040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EJC51_RS25045 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EJC51_RS25050 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EJC51_RS25055 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EJC51_RS25060 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EJC51_RS25075 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase EJC51_RS25085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS25090 ENOG4108IG5 Transcriptional regulator EJC51_RS25110 ENOG4107QSN dihydrolipoamide acetyltransferase EJC51_RS25155 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 EJC51_RS25160 ENOG4105CPP Dehydrogenase, E1 component EJC51_RS25190 ENOG4107QPV Serine Threonine protein kinase EJC51_RS25230 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS25255 ENOG4105DFM M18 family aminopeptidase EJC51_RS25260 ENOG4105CSU acyl-Coa dehydrogenase EJC51_RS25280 ENOG4105EUB pirin domain protein EJC51_RS25300 ENOG4105C9M aspartyl-trna synthetase EJC51_RS25335 ENOG4105CPF Cell wall formation (By similarity) EJC51_RS25375 ENOG4105D7W serine acetyltransferase EJC51_RS25380 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJC51_RS25400 ENOG4105KWG Pfam:DUF1696 EJC51_RS25415 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EJC51_RS25430 ENOG410613R integral membrane protein, YccS YhfK family EJC51_RS25440 ENOG4105F2Z 3-oxoadipate enol-lactonase EJC51_RS25445 ENOG4107U9B transcriptional regulator EJC51_RS25475 ENOG4105CH2 amidohydrolase EJC51_RS25495 ENOG4108HMN Caspase domain EJC51_RS25515 ENOG4105C22 threonyL-tRNA synthetase EJC51_RS25520 ENOG4105DU0 nucleoside hydrolase EJC51_RS25530 ENOG4105CG3 alpha amylase, catalytic region EJC51_RS25570 ENOG4105CMR udp-glucose 4-epimerase EJC51_RS25585 ENOG4105DFW ABC transporter EJC51_RS25590 ENOG4108KPJ rna polymerase sigma factor EJC51_RS25630 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS25645 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase EJC51_RS25685 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EJC51_RS25700 ENOG4105D8K carboxyl transferase EJC51_RS25720 ENOG4108IG5 Transcriptional regulator EJC51_RS25730 ENOG41064MX Tetr family transcriptional regulator EJC51_RS25735 ENOG4105ECY inositol monophosphatase EJC51_RS25790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS25795 ENOG4105BZU Histidine kinase EJC51_RS25820 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EJC51_RS25845 ENOG4105RNG membrane EJC51_RS25850 ENOG4105K6V RNA polymerase EJC51_RS25855 ENOG4105NAF rna polymerase sigma factor EJC51_RS25890 ENOG4105VEQ Cold shock protein EJC51_RS25925 ENOG4105VEQ Cold shock protein EJC51_RS26000 ENOG4105BZU Histidine kinase EJC51_RS26005 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EJC51_RS26015 ENOG4107S46 esterase, PHB depolymerase EJC51_RS26065 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EJC51_RS26090 ENOG4105CMD Transcriptional regulator, GntR family EJC51_RS26145 ENOG4105DHP deoxycytidine triphosphate deaminase EJC51_RS26200 ENOG4105NX3 Membrane EJC51_RS26205 ENOG4105DF6 Fe-S oxidoreductase EJC51_RS26215 ENOG4105CFG Acts as a chaperone (By similarity) EJC51_RS26220 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EJC51_RS26225 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EJC51_RS26230 ENOG4105KNI merR family transcriptional Regulator EJC51_RS26245 ENOG4105DFW ABC transporter EJC51_RS26300 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EJC51_RS26335 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJC51_RS26345 ENOG4105BZU Histidine kinase EJC51_RS26350 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS26365 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EJC51_RS26370 ENOG4107RCW fructose-bisphosphate aldolase EJC51_RS26390 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) EJC51_RS26425 ENOG4105BZU Histidine kinase EJC51_RS26430 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS26435 ENOG4105BZU Histidine kinase EJC51_RS26440 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS26490 ENOG4107SET aldo keto reductase EJC51_RS26505 ENOG4105DIM ABC transporter EJC51_RS26510 ENOG4105CIG ABC transporter EJC51_RS26525 ENOG4105CPD ethanolamine ammonia-lyase EJC51_RS26530 ENOG4107FQ9 ethanolamine ammonia-lyase EJC51_RS26545 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EJC51_RS26555 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EJC51_RS26575 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS26580 ENOG4108JPW Aminotransferase EJC51_RS26600 ENOG4108S01 response regulator EJC51_RS26605 ENOG4108ZGX Histidine kinase EJC51_RS26620 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EJC51_RS26625 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EJC51_RS26685 ENOG4105EB3 Histidine kinase EJC51_RS26695 ENOG4105CFH Aspartokinase EJC51_RS26705 ENOG4105NAF rna polymerase sigma factor EJC51_RS26735 ENOG4108PJD permease EJC51_RS26750 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF EJC51_RS26820 ENOG4105BZ4 penicillin-binding protein EJC51_RS26860 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJC51_RS26880 ENOG4105P8F nudix hydrolase EJC51_RS26895 ENOG4105D74 hydrolase EJC51_RS26905 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EJC51_RS26910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJC51_RS26925 ENOG4107B2H carbonic anhydrase EJC51_RS26985 ENOG4108I5C dEAD DEAH box helicase EJC51_RS26990 ENOG4105WN5 stage II sporulation protein EJC51_RS27000 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for EJC51_RS27010 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EJC51_RS27025 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EJC51_RS27030 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EJC51_RS27035 ENOG4105C6E dna polymerase iii EJC51_RS27085 ENOG4105VBF alkaline shock protein EJC51_RS27150 ENOG4105C2M dna polymerase I EJC51_RS27160 ENOG410829K Lysine exporter protein (Lyse ygga) EJC51_RS27180 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EJC51_RS27185 ENOG4105KDC 50s ribosomal protein l28 EJC51_RS27190 ENOG4105W0E 50S ribosomal protein L33 EJC51_RS27195 ENOG4105NRA 50s ribosomal protein l31 type b EJC51_RS27205 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EJC51_RS27245 ENOG4105C26 Dehydrogenase EJC51_RS27270 ENOG4105CVK Glutamate decarboxylase EJC51_RS27280 ENOG4107TXC Transcriptional regulator EJC51_RS27285 ENOG41082VC UPF0145 protein EJC51_RS27300 ENOG4105F0N pyrophosphate phospho-hydrolase EJC51_RS27315 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EJC51_RS27320 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJC51_RS27330 ENOG4105EUJ GTP cyclohydrolase i EJC51_RS27340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EJC51_RS27360 ENOG4105CRK lysyL-tRNA synthetase EJC51_RS27385 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS27405 ENOG4105I1F Resistance protein EJC51_RS27430 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EJC51_RS27435 ENOG4108IYU L-aspartate oxidase EJC51_RS27445 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EJC51_RS27500 ENOG4105DR5 peptidase EJC51_RS27510 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS27515 ENOG4105UEI Transcriptional Regulator AraC Family EJC51_RS27525 ENOG4108FKE two-component system sensor kinase EJC51_RS27530 ENOG4108PYU two-component system response regulator EJC51_RS27535 ENOG41075QH Lipoprotein CseA EJC51_RS27540 ENOG4105NAF rna polymerase sigma factor EJC51_RS27555 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EJC51_RS27575 ENOG4108JWX EJC51_RS27580 ENOG4107R33 ppx gppa phosphatase EJC51_RS27585 ENOG4105EY0 Xylose isomerase domain protein TIM barrel EJC51_RS27590 ENOG4105PF9 Transcriptional regulator EJC51_RS27595 ENOG4105C01 Dihydroxy-acid dehydratase EJC51_RS27605 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein EJC51_RS27610 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein EJC51_RS27635 ENOG4105CJ1 ABC, transporter EJC51_RS27645 ENOG4105II7 pyrroline-5-carboxylate reductase EJC51_RS27650 ENOG4105C31 Tryptophanyl-tRNA synthetase EJC51_RS27675 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EJC51_RS27690 ENOG4105DGU Histone deacetylase EJC51_RS27700 ENOG4108XFF EJC51_RS27745 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EJC51_RS27750 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EJC51_RS27755 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EJC51_RS27760 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJC51_RS27780 ENOG4105D52 delta-aminolevulinic acid dehydratase EJC51_RS27800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS27835 ENOG4105C75 arginyL-tRNA synthetase EJC51_RS27845 ENOG4105DK7 lysyl-tRNA synthetase EJC51_RS27865 ENOG4105E0Y RtcB Protein EJC51_RS27885 ENOG4105KK4 UPF0060 membrane protein EJC51_RS27900 ENOG4105KVH Transcriptional regulator EJC51_RS27920 ENOG4108PG2 copper resistance EJC51_RS27940 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJC51_RS27945 ENOG4108UZX fmn reductase EJC51_RS27950 ENOG4105ETX regulatoR EJC51_RS27985 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EJC51_RS28010 ENOG4105HS2 Arsenate reductase EJC51_RS28015 ENOG4107YCR Transcriptional regulator, ARSR family EJC51_RS28020 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJC51_RS28025 ENOG41082YX Transcriptional regulator, arsr family EJC51_RS28040 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EJC51_RS28045 ENOG4108RH7 phosphoglycerate mutase EJC51_RS28055 ENOG4107ZT5 Thiol disulfide interchange protein EJC51_RS28060 ENOG4107QIV Cytochrome c biogenesis protein EJC51_RS28065 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) EJC51_RS28070 ENOG4105CRE cytochrome C EJC51_RS28095 ENOG4105CDH Citrulline--aspartate ligase EJC51_RS28105 ENOG4105YVS arsR family transcriptional regulator EJC51_RS28125 ENOG4107V2S Transcriptional regulator EJC51_RS28135 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EJC51_RS28140 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EJC51_RS28145 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EJC51_RS28150 ENOG4105EW9 transcriptional regulator AsnC family EJC51_RS28155 ENOG4105DVY radical SAM domain protein EJC51_RS28160 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EJC51_RS28185 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EJC51_RS28200 ENOG4105CHR reductase EJC51_RS28205 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS28215 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) EJC51_RS28250 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein EJC51_RS28255 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EJC51_RS28270 ENOG4108IMY Transcriptional regulator EJC51_RS28275 ENOG4105VEQ Cold shock protein EJC51_RS28280 ENOG4105EV6 Pfam:DUF178 EJC51_RS28385 ENOG4108EHY type IV secretion system EJC51_RS28480 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) EJC51_RS28495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJC51_RS28515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJC51_RS28520 ENOG41068JE domain protein EJC51_RS28530 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28535 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJC51_RS28540 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28550 ENOG4107QIZ NADH dehydrogenase EJC51_RS28555 ENOG4108IEH NADH dehydrogenase subunit g EJC51_RS28560 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EJC51_RS28565 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28570 ENOG41087XN oxidoreductase EJC51_RS28575 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28580 ENOG4105D65 subunit l EJC51_RS28590 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28600 ENOG4105C9U ATP-dependent DNA helicase RecQ EJC51_RS28605 ENOG4108IYU L-aspartate oxidase EJC51_RS28610 ENOG4108IY8 ABC, transporter EJC51_RS28615 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJC51_RS28630 ENOG4105FDP GntR family transcriptional regulator EJC51_RS28650 ENOG4105CAY ferredoxin--nadp reductase EJC51_RS28660 ENOG410667J hydrolase EJC51_RS28675 ENOG4105DUX Transporter EJC51_RS28705 ENOG4108WS4 fmn reductase EJC51_RS28735 ENOG4105ECR NmrA family EJC51_RS28740 ENOG4105KVH Transcriptional regulator EJC51_RS28750 ENOG4105DQU oxidoreductase, subunit beta EJC51_RS28755 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EJC51_RS28765 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJC51_RS28780 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJC51_RS28785 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28790 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJC51_RS28795 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EJC51_RS28800 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28810 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28815 ENOG4105D65 subunit l EJC51_RS28820 ENOG4105C8S subunit m EJC51_RS28825 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJC51_RS28830 ENOG4105D0M Protease HtpX homolog EJC51_RS28835 ENOG410901E Membrane EJC51_RS28850 ENOG4105Y3U Transglycosylase-associated protein EJC51_RS28855 ENOG4108VPT UPF0234 protein EJC51_RS28890 ENOG4105WDJ 50S ribosomal protein L33 EJC51_RS28895 ENOG410900P UPF0336 protein EJC51_RS28915 ENOG4107R4N Cell wall formation (By similarity) EJC51_RS28935 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJC51_RS28955 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EJC51_RS28970 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EJC51_RS28980 ENOG4105QCJ Lipoprotein EJC51_RS28985 ENOG4108VZM 50s ribosomal protein L10 EJC51_RS28990 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EJC51_RS29000 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJC51_RS29005 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJC51_RS29015 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EJC51_RS29020 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EJC51_RS29025 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EJC51_RS29065 ENOG4105CNA YD repeat protein EJC51_RS29095 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EJC51_RS29100 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EJC51_RS29105 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EJC51_RS29110 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EJC51_RS29115 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EJC51_RS29120 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EJC51_RS29125 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EJC51_RS29130 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EJC51_RS29135 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EJC51_RS29140 ENOG41082SA 50s ribosomal protein l29 EJC51_RS29145 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EJC51_RS29150 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EJC51_RS29155 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EJC51_RS29160 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EJC51_RS29165 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EJC51_RS29175 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EJC51_RS29180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EJC51_RS29185 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EJC51_RS29190 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EJC51_RS29195 ENOG410849U 50S ribosomal protein L30 EJC51_RS29200 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EJC51_RS29210 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EJC51_RS29220 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EJC51_RS29225 ENOG41067V7 50S ribosomal protein L36 EJC51_RS29230 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EJC51_RS29235 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EJC51_RS29240 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJC51_RS29245 ENOG4108ZT0 50S ribosomal protein l17 EJC51_RS29250 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EJC51_RS29260 ENOG4107QZ7 Cellulose synthase catalytic subunit EJC51_RS29295 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EJC51_RS29300 ENOG4108UJD 30S ribosomal protein S9 EJC51_RS29305 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EJC51_RS29315 ENOG4105CS9 pantothenic acid kinase EJC51_RS29320 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJC51_RS29345 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJC51_RS29350 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 EJC51_RS29355 ENOG4108097 ATP-binding protein EJC51_RS29375 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EJC51_RS29390 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJC51_RS29395 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS29415 ENOG4105CHP RNA polymerase EJC51_RS29445 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EJC51_RS29465 ENOG4105CPF Cell wall formation (By similarity) EJC51_RS29475 ENOG4105EMU Dehydrogenase EJC51_RS29515 ENOG4105CAS nag kinase EJC51_RS29525 ENOG4105EMU Dehydrogenase EJC51_RS29535 ENOG4105DND Transcriptional regulator EJC51_RS29540 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS29550 ENOG4108MMM RNA Polymerase EJC51_RS29560 ENOG4107QVP Dehydrogenase EJC51_RS29565 ENOG4107QQG Dehydrogenase EJC51_RS29570 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJC51_RS29585 ENOG4105D9P serine threonine protein kinase EJC51_RS29590 ENOG4105D9P serine threonine protein kinase EJC51_RS29605 ENOG4107TPY serine threonine protein kinase EJC51_RS29615 ENOG4105C26 Dehydrogenase EJC51_RS29640 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EJC51_RS29700 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS29725 ENOG4108HMN Caspase domain EJC51_RS29735 ENOG4105K4H Nlp p60 protein EJC51_RS29755 ENOG4105C4R Atp-dependent dna helicase EJC51_RS29790 ENOG4105KKX ATPase associated with various cellular activities aaa_5 EJC51_RS29795 ENOG4105RD5 EJC51_RS29805 ENOG4105DEG Vwa containing coxe family protein EJC51_RS29825 ENOG4105CMV Succinyl-CoA synthetase subunit beta EJC51_RS29855 ENOG4105DC1 bifunctional purine biosynthesis protein purh EJC51_RS29865 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJC51_RS29885 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJC51_RS29895 ENOG4105C57 major facilitator superfamily EJC51_RS29935 ENOG4108IJ7 Glycine betaine EJC51_RS29940 ENOG4108HQS Glycine betaine EJC51_RS29955 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS29960 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS29965 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJC51_RS29980 ENOG4106032 Glutathionylspermidine synthase EJC51_RS29985 ENOG4108YRB methyltransferase EJC51_RS29990 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS29995 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJC51_RS30010 ENOG4105EMN RNA polymerase sigma factor EJC51_RS30015 ENOG4105C31 Tryptophanyl-tRNA synthetase EJC51_RS30040 ENOG4106YN8 Prenyltransferase EJC51_RS30045 ENOG4107H3J ribonuclease EJC51_RS30060 ENOG4107RN3 metallophosphoesterase EJC51_RS30075 ENOG4105BZU Histidine kinase EJC51_RS30080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS30085 ENOG4105EYF MMPL domain protein EJC51_RS30090 ENOG4105U5Y Transcriptional regulator EJC51_RS30120 ENOG4108J01 L-aspartate oxidase EJC51_RS30140 ENOG4105E2D ec 3.2.1.52 EJC51_RS30190 ENOG4108MMM RNA Polymerase EJC51_RS30210 ENOG4108NIW Leucine export protein LeuE EJC51_RS30260 ENOG4105K64 Glycosyl transferase, family 2 EJC51_RS30270 ENOG4105F0R Cytidylyltransferase EJC51_RS30275 ENOG4105D2T synthase EJC51_RS30300 ENOG4107RM1 amidohydrolase EJC51_RS30305 ENOG4105DIH basic membrane EJC51_RS30310 ENOG4105DIH basic membrane EJC51_RS30315 ENOG4108JQ9 ABC transporter EJC51_RS30360 ENOG4105D94 Major Facilitator Superfamily EJC51_RS30365 ENOG4107RSM transcriptional regulator EJC51_RS30375 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJC51_RS30400 ENOG41065SU Two-component system sensor kinase EJC51_RS30405 ENOG4108KXV response regulator EJC51_RS30410 ENOG4105NAF rna polymerase sigma factor EJC51_RS30430 ENOG4105C26 Dehydrogenase EJC51_RS30435 ENOG4105C26 Dehydrogenase EJC51_RS30460 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain EJC51_RS30500 ENOG4108JIK carboxylase EJC51_RS30510 ENOG4107WR6 Maf-like protein EJC51_RS30530 ENOG4105D8K carboxyl transferase EJC51_RS30540 ENOG4108QER Adenylate cyclase EJC51_RS30550 ENOG4105E39 Enoyl-CoA hydratase EJC51_RS30555 ENOG4105KDM Diguanylate cyclase with gaf sensor EJC51_RS30560 ENOG4105C84 Histidine ammonia-lyase EJC51_RS30595 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS30615 ENOG4105DQ4 alcohol dehydrogenase EJC51_RS30635 ENOG4107S9F NmrA family EJC51_RS30640 ENOG4105FDP GntR family transcriptional regulator EJC51_RS30660 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EJC51_RS30680 ENOG4105NAF rna polymerase sigma factor EJC51_RS30685 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EJC51_RS30690 ENOG4105C7B Threonine dehydratase EJC51_RS30705 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EJC51_RS30715 ENOG4105T1M mycothiol conjugate amidase mca EJC51_RS30735 ENOG4105C7Z Conserved Protein EJC51_RS30770 ENOG4105C57 major facilitator superfamily EJC51_RS30780 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) EJC51_RS30785 ENOG4108762 serine threonine protein kinase EJC51_RS30870 ENOG4108FUF Transcriptional regulator, IclR family EJC51_RS30875 ENOG4105KME endoribonuclease L-psp EJC51_RS30880 ENOG4105C6Z Gluconate EJC51_RS30905 ENOG4108U3T pfkb domain protein EJC51_RS30955 ENOG4105EEM helicase EJC51_RS31010 ENOG4105RAK Histidine kinase EJC51_RS31015 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS31115 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJC51_RS31125 ENOG4108IAB Phoh family EJC51_RS31130 ENOG4106770 Is able to cleave peptidoglycan (By similarity) EJC51_RS31140 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS31145 ENOG4105D3R alkyl hydroperoxide reductase EJC51_RS31175 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS31195 ENOG4105BZ4 penicillin-binding protein EJC51_RS31210 ENOG4105C9Q fumarate hydratase class II EJC51_RS31215 ENOG4107GFK fumarate EJC51_RS31225 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS31240 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) EJC51_RS31245 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EJC51_RS31250 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EJC51_RS31260 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EJC51_RS31275 ENOG4105C3G gtp-binding protein EJC51_RS31295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS31300 ENOG4108SGK Tetr family transcriptional regulator EJC51_RS31305 ENOG4105C57 major facilitator superfamily EJC51_RS31325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS31350 ENOG4105KTE polyketide synthesis cyclase EJC51_RS31360 ENOG4105CZS beta-ketoacyl synthase EJC51_RS31390 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS31395 ENOG4105CHR reductase EJC51_RS31450 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EJC51_RS31475 ENOG4105CI3 gtp-binding protein typa EJC51_RS31480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS31485 ENOG4108J59 Extracellular solute-binding protein, family 5 EJC51_RS31500 ENOG4108JQ7 (ABC) transporter EJC51_RS31530 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EJC51_RS31540 ENOG4108JQ7 (ABC) transporter EJC51_RS31555 ENOG4105DEF Extracellular solute-binding protein, family 5 EJC51_RS31560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS31570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJC51_RS31575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS31580 ENOG4105C3U ABC transporter EJC51_RS31585 ENOG4108JQ7 (ABC) transporter EJC51_RS31615 ENOG4108M15 ABC transporter EJC51_RS31625 ENOG4105BZU Histidine kinase EJC51_RS31630 ENOG4108S01 response regulator EJC51_RS31645 ENOG4108Z4U Ferredoxin EJC51_RS31665 ENOG4107R4C succinyl-diaminopimelate desuccinylase EJC51_RS31670 ENOG4108URH decarboxylase EJC51_RS31675 ENOG4105EEI dihydropteroate synthase EJC51_RS31685 ENOG4108R3E Dna-3-methyladenine glycosylase i EJC51_RS31690 ENOG4105CGU Enoyl-CoA hydratase EJC51_RS31705 ENOG4105DU6 RNA polymerase EJC51_RS31715 ENOG4105C0H protease EJC51_RS31720 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EJC51_RS31755 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS31765 ENOG4105DXB Major Facilitator superfamily EJC51_RS31780 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EJC51_RS31845 ENOG4105DEF Extracellular solute-binding protein, family 5 EJC51_RS31850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS31915 ENOG4105C4R Atp-dependent dna helicase EJC51_RS31920 ENOG4107QSE Dipeptidase EJC51_RS31945 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS31960 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EJC51_RS32010 ENOG41063PX domain protein EJC51_RS32020 ENOG4105DJZ UPF0182 protein EJC51_RS32065 ENOG4107TK4 histidinol-phosphate phosphatase EJC51_RS32075 ENOG4105KPY Small multidrug resistance protein EJC51_RS32085 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EJC51_RS32095 ENOG4108RAV Conserved protein EJC51_RS32105 ENOG4105EMN RNA polymerase sigma factor EJC51_RS32110 ENOG4105WMN AntiSigma factor EJC51_RS32115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJC51_RS32130 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJC51_RS32140 ENOG41068W2 Cytochrome p-450 EJC51_RS32160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJC51_RS32165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJC51_RS32190 ENOG4105D22 carbon starvation protein EJC51_RS32195 ENOG4105FDP GntR family transcriptional regulator EJC51_RS32215 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJC51_RS32220 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EJC51_RS32225 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJC51_RS32230 ENOG4105CHR reductase EJC51_RS32250 ENOG4105CBD Diacylglycerol kinase EJC51_RS32280 ENOG4105K6H D-cysteine desulfhydrase EJC51_RS32290 ENOG4105ESN nucleotide-binding protein EJC51_RS32325 ENOG4105CHP RNA polymerase EJC51_RS32365 ENOG4108VEQ Superoxide dismutase EJC51_RS32380 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJC51_RS32385 ENOG4105CDA abc transporter atp-binding protein EJC51_RS32390 ENOG4105E5Q amino acid AbC transporter EJC51_RS32405 ENOG4105C6K Malic enzyme EJC51_RS32410 ENOG4105CB2 alcohol dehydrogenase EJC51_RS32455 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EJC51_RS32460 ENOG4105EB3 Histidine kinase EJC51_RS32465 ENOG4108PYU two-component system response regulator EJC51_RS32500 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EJC51_RS32590 ENOG4107QHZ cell cycle protein EJC51_RS32600 ENOG4108FKE two-component system sensor kinase EJC51_RS32625 ENOG4105DQE DNA ligase EJC51_RS32630 ENOG4105FDF Could be involved in DNA repair (By similarity) EJC51_RS32670 ENOG41062IR nudix hydrolase EJC51_RS32725 ENOG4107RHI Cytosine-specific methyltransferase EJC51_RS32740 ENOG4107ZVI PhiRv2 prophage protein EJC51_RS32760 ENOG4105ETX regulatoR EJC51_RS32765 ENOG4105C75 arginyL-tRNA synthetase EJC51_RS32770 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJC51_RS32775 ENOG4105D6E homoserine dehydrogenase EJC51_RS32780 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EJC51_RS32785 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EJC51_RS32795 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJC51_RS32800 ENOG4108RCF TRANSCRIPTIONal EJC51_RS32805 ENOG4105VFB Binds the 23S rRNA (By similarity) EJC51_RS32810 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EJC51_RS32815 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJC51_RS32825 ENOG4107ZF2 Phosphatase EJC51_RS32830 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJC51_RS32840 ENOG4105Z3P ATP synthase EJC51_RS32850 ENOG4105ZA1 atp synthase EJC51_RS32855 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) EJC51_RS32860 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EJC51_RS32865 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EJC51_RS32870 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EJC51_RS32875 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EJC51_RS32880 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EJC51_RS32895 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS32900 ENOG4105BZU Histidine kinase EJC51_RS32925 ENOG410630P Transcriptional regulator EJC51_RS32930 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS32945 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) EJC51_RS32980 ENOG4105CJ1 ABC, transporter EJC51_RS33000 ENOG4108ZVT methylmalonyl-coA epimerase EJC51_RS33005 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS33025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS33095 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJC51_RS33115 ENOG4105WX6 Membrane EJC51_RS33155 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EJC51_RS33160 ENOG4105C6K Malic enzyme EJC51_RS33165 ENOG4105CTQ phosphohexokinase EJC51_RS33195 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EJC51_RS33220 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EJC51_RS33240 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJC51_RS33245 ENOG4107QJT sodium dicarboxylate symporter EJC51_RS33280 ENOG4108FN7 Aldo keto reductase EJC51_RS33315 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EJC51_RS33320 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) EJC51_RS33330 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) EJC51_RS33335 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS33340 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EJC51_RS33360 ENOG4105BZ1 (ABC) transporter EJC51_RS33365 ENOG4105BZ1 (ABC) transporter EJC51_RS33370 ENOG4105BZ1 (ABC) transporter EJC51_RS33375 ENOG4105BZ1 (ABC) transporter EJC51_RS33380 ENOG4105CJ1 ABC, transporter EJC51_RS33395 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS33400 ENOG41061MV Arylsulfatase EJC51_RS33410 ENOG4107UBC ErfK ybiS ycfS ynhG family protein EJC51_RS33415 ENOG4105S7A ErfK ybiS ycfS ynhG family protein EJC51_RS33460 ENOG4105E7U AraC family transcriptional regulator EJC51_RS33470 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) EJC51_RS33480 ENOG4107YXZ hydrolase, family 25 EJC51_RS33485 ENOG4105EJQ L-serine dehydratase EJC51_RS33490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EJC51_RS33495 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EJC51_RS33500 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EJC51_RS33520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS33525 ENOG4108J59 Extracellular solute-binding protein, family 5 EJC51_RS33540 ENOG4108JQ7 (ABC) transporter EJC51_RS33550 ENOG4105EN6 Membrane EJC51_RS33595 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EJC51_RS33600 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EJC51_RS33615 ENOG4108URH decarboxylase EJC51_RS33620 ENOG4105EMU Dehydrogenase EJC51_RS33630 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJC51_RS33635 ENOG4105BZU Histidine kinase EJC51_RS33640 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EJC51_RS33645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJC51_RS33655 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EJC51_RS33670 ENOG4105EYF MMPL domain protein EJC51_RS33675 ENOG4105D9U N-acetyltransferase EJC51_RS33690 ENOG4107SM8 Adenylate Guanylate cyclase EJC51_RS33705 ENOG4105CPC Aldo Keto reductase EJC51_RS33715 ENOG4105BZU Histidine kinase EJC51_RS33725 ENOG4108ZP8 Acetolactate synthase small subunit EJC51_RS33730 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJC51_RS33735 ENOG4108JQ1 Dehydrogenase EJC51_RS33740 ENOG4105C57 major facilitator superfamily EJC51_RS33750 ENOG4108JQ7 (ABC) transporter EJC51_RS33760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS33770 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EJC51_RS33780 ENOG4105C26 Dehydrogenase EJC51_RS33795 ENOG41080UQ Transcriptional regulator EJC51_RS33810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EJC51_RS33815 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJC51_RS33830 ENOG4105CQM Urea amidohydrolase subunit alpha EJC51_RS33835 ENOG4105DWY Agmatine deiminase EJC51_RS33865 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EJC51_RS33880 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJC51_RS33890 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJC51_RS33900 ENOG4108YYC ycei family EJC51_RS33905 ENOG4106AM8 polysaccharide lyase family 8 EJC51_RS33910 ENOG4105D8K carboxyl transferase EJC51_RS33930 ENOG4105GWZ Roadblock lc7 family protein EJC51_RS33950 ENOG4105GWZ Roadblock lc7 family protein EJC51_RS33965 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EJC51_RS33970 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EJC51_RS34015 ENOG41069M3 Transcriptional regulator EJC51_RS34020 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJC51_RS34025 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EJC51_RS34035 ENOG4105K70 DNA-binding protein EJC51_RS34055 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EJC51_RS34060 ENOG4105CPF Cell wall formation (By similarity) EJC51_RS34080 ENOG4105DWF phosphomethylpyrimidine kinase EJC51_RS34085 ENOG4105VB9 50S ribosomal protein l28 EJC51_RS34090 ENOG4105DP4 dak2 domain fusion protein ylov EJC51_RS34100 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EJC51_RS34110 ENOG4106H78 methyltransferase EJC51_RS34115 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EJC51_RS34130 ENOG41084BZ 50S ribosomal protein L32 EJC51_RS34135 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EJC51_RS34140 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EJC51_RS34145 ENOG4105KVH Transcriptional regulator EJC51_RS34150 ENOG4105CS1 NAD(P)H quinone oxidoreductase EJC51_RS34155 ENOG4105K4I Scp-like extracellular EJC51_RS34160 ENOG4108375 Acylphosphatase (EC 3.6.1.7) EJC51_RS34175 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EJC51_RS34215 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EJC51_RS34225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EJC51_RS34240 ENOG4105K5M 30s ribosomal protein S16 EJC51_RS34245 ENOG41082KU UPF0109 protein EJC51_RS34250 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EJC51_RS34255 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EJC51_RS34260 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EJC51_RS34270 ENOG4107QYR Signal peptidase i EJC51_RS34295 ENOG41080R2 UPF0102 protein EJC51_RS34310 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS34320 ENOG41063SB peptidase EJC51_RS34325 ENOG4105CE9 30S ribosomal protein S2 EJC51_RS34330 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EJC51_RS34335 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJC51_RS34340 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EJC51_RS34345 ENOG4105KNE Phosphatidate cytidylyltransferase EJC51_RS34360 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EJC51_RS34370 ENOG4108I5D sulfate abc transporter EJC51_RS34375 ENOG4108UCS ABC, transporter EJC51_RS34405 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS34410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJC51_RS34420 ENOG4105C26 Dehydrogenase EJC51_RS34445 ENOG4105JVQ RNA Polymerase EJC51_RS34460 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJC51_RS34465 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EJC51_RS34490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS34495 ENOG4105F38 ABC transporter, permease EJC51_RS34500 ENOG4105D38 putrescine abc transporter EJC51_RS34505 ENOG4105CJP fad dependent oxidoreductase EJC51_RS34515 ENOG4107SQD Transcriptional regulator, GntR family EJC51_RS34550 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EJC51_RS34560 ENOG4105E0S extracellular solute-binding protein family 1 EJC51_RS34570 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJC51_RS34615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJC51_RS34620 ENOG4105DZP Membrane-associated zinc metalloprotease EJC51_RS34625 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EJC51_RS34640 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EJC51_RS34655 ENOG4105EMN RNA polymerase sigma factor EJC51_RS34675 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase EJC51_RS34695 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) EJC51_RS34710 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EJC51_RS34720 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EJC51_RS34725 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EJC51_RS34755 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EJC51_RS34760 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EJC51_RS34765 ENOG4105C1V Peptidase, M16 EJC51_RS34770 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EJC51_RS34795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJC51_RS34800 ENOG4105CN5 Metallo-Beta-Lactamase EJC51_RS34845 ENOG4105BZU Histidine kinase EJC51_RS34850 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EJC51_RS34855 ENOG4107QZI cell division protein FtsK EJC51_RS34865 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) EJC51_RS34875 ENOG4105CEV competence damage-inducible protein EJC51_RS34880 ENOG4105WBV Transcriptional regulator EJC51_RS34885 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction EJC51_RS34900 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) EJC51_RS34905 ENOG4107QRT dEAD DEAH box helicase EJC51_RS34910 ENOG41075H3 AraC family transcriptional regulator EJC51_RS34935 ENOG4105DSF transport protein EJC51_RS34945 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EJC51_RS34965 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EJC51_RS34970 ENOG4105DRP amino acid AbC transporter EJC51_RS34975 ENOG4108Q1T ABC transporter EJC51_RS34980 ENOG4107UBR Extracellular solute-binding protein family 3 EJC51_RS34985 ENOG4105CDA abc transporter atp-binding protein EJC51_RS34990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS34995 ENOG4105EB3 Histidine kinase EJC51_RS35000 ENOG4105H1G trap transporter solute receptor taxi family EJC51_RS35020 ENOG4105BZU Histidine kinase EJC51_RS35025 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS35040 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJC51_RS35060 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EJC51_RS35070 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EJC51_RS35075 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJC51_RS35085 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJC51_RS35120 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EJC51_RS35125 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EJC51_RS35130 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJC51_RS35170 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJC51_RS35185 ENOG4105C9U ATP-dependent DNA helicase RecQ EJC51_RS35210 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS35215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS35220 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJC51_RS35230 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJC51_RS35255 ENOG4107QN1 sodium solute EJC51_RS35260 ENOG4108V9W transcriptional regulatory protein EJC51_RS35270 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJC51_RS35280 ENOG4108V9W transcriptional regulatory protein EJC51_RS35285 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJC51_RS35295 ENOG4105BZN citrate synthase EJC51_RS35300 ENOG4105BZN citrate synthase EJC51_RS35320 ENOG4105CKI cobalamin synthesis protein EJC51_RS35325 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJC51_RS35345 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS35350 ENOG410849S phosphocarrier protein (HPr) EJC51_RS35360 ENOG4105CD5 CoA-binding domain protein EJC51_RS35375 ENOG4107W53 thymidine kinase EJC51_RS35420 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EJC51_RS35430 ENOG4105F44 Two component transcriptional regulator, winged helix family EJC51_RS35435 ENOG4106F60 Histidine kinase EJC51_RS35460 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EJC51_RS35475 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS35505 ENOG4107VEG TrkA-N domain protein EJC51_RS35510 ENOG4105C0X amino acid EJC51_RS35515 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EJC51_RS35520 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS35550 ENOG4105C5I Dehydrogenase EJC51_RS35575 ENOG4105CQB FAD linked oxidase domain protein EJC51_RS35595 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EJC51_RS35635 ENOG4107S1Q Phosphatase EJC51_RS35650 ENOG4105CEU Arginine dihydrolase EJC51_RS35655 ENOG4105DBV ornithine carbamoyltransferase EJC51_RS35660 ENOG4105CUB amino acid EJC51_RS35670 ENOG4105CGU Enoyl-CoA hydratase EJC51_RS35710 ENOG41067SE Tetr family transcriptional regulator EJC51_RS35715 ENOG4105EYF MMPL domain protein EJC51_RS35730 ENOG4105CTU Proline racemase EJC51_RS35750 ENOG4105MWK D-amino acid dehydrogenase, small subunit EJC51_RS35750 ENOG4105MWK D-amino acid dehydrogenase, small subunit EJC51_RS35755 ENOG4105K4H Nlp p60 protein EJC51_RS35760 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJC51_RS35775 ENOG4107QM5 aconitate hydratase EJC51_RS35780 ENOG4105BZU Histidine kinase EJC51_RS35805 ENOG4105CWX Alpha-1,2-mannosidase EJC51_RS35810 ENOG4105I82 acetyl xylan esterase EJC51_RS35820 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJC51_RS35850 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJC51_RS35885 ENOG4105E2R ROK family EJC51_RS35890 ENOG4105DFW ABC transporter EJC51_RS35895 ENOG4105C2J ABC transporter EJC51_RS35900 ENOG4108HWW ABC transporter EJC51_RS35905 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EJC51_RS35910 ENOG4105CUB amino acid EJC51_RS35920 ENOG4108HGY Proline imino-peptidase EJC51_RS35930 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJC51_RS35945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS35950 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS35955 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS35980 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EJC51_RS35995 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EJC51_RS36010 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EJC51_RS36025 ENOG4107JTW chlorite dismutase EJC51_RS36045 ENOG4105E18 UPF0276 protein EJC51_RS36075 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS36080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJC51_RS36105 ENOG4105CSR polyphosphate kinase 2 EJC51_RS36125 ENOG4107B2H carbonic anhydrase EJC51_RS36145 ENOG4105DFU Cell wall formation (By similarity) EJC51_RS36150 ENOG4105E0X reductase EJC51_RS36165 ENOG4105JSC dimethylmenaquinone methyltransferase EJC51_RS36175 ENOG4105D17 glycoside hydrolase, family 3 domain protein EJC51_RS36195 ENOG4105DRS transport system, permease EJC51_RS36220 ENOG4105QEK Transcriptional regulator EJC51_RS36225 ENOG4108SU4 UPF0309 protein EJC51_RS36230 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 EJC51_RS36250 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS36255 ENOG4105BZU Histidine kinase EJC51_RS36260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJC51_RS36275 ENOG4105CJ2 (LipO)protein EJC51_RS36290 ENOG4108IJ8 ABC transporter EJC51_RS36295 ENOG4105E90 ABC transporter EJC51_RS36300 ENOG4105E90 ABC transporter EJC51_RS36305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS36310 ENOG4108KPJ rna polymerase sigma factor EJC51_RS36325 ENOG4105GWZ Roadblock lc7 family protein EJC51_RS36360 ENOG41062D9 Histidine kinase EJC51_RS36375 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EJC51_RS36405 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS36410 ENOG4108XG4 DNA-binding transcriptional regulator EJC51_RS36440 ENOG4108ETV ABC transporter EJC51_RS36445 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein EJC51_RS36450 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EJC51_RS36460 ENOG4105C0H protease EJC51_RS36465 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EJC51_RS36500 ENOG4105ZSU inhibitor EJC51_RS36580 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJC51_RS36585 ENOG4105MC2 DSBA oxidoreductase EJC51_RS36605 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJC51_RS36615 ENOG4107Z6I Thiamine biosynthesis protein EJC51_RS36640 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EJC51_RS36665 ENOG4107RR1 TRANSCRIPTIONal EJC51_RS36670 ENOG4105CSU acyl-Coa dehydrogenase EJC51_RS36715 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS36720 ENOG4105EBR Carboxylesterase EJC51_RS36730 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS36735 ENOG4108J5H Homocysteine s-methyltransferase EJC51_RS36760 ENOG4107TDE lipolytic protein G-D-S-L family EJC51_RS36825 ENOG4105CJ1 ABC, transporter EJC51_RS36835 ENOG4105DRS transport system, permease EJC51_RS36855 ENOG4105QE3 oxidoreductase EJC51_RS36875 ENOG41065HY 1,4-beta-cellobiosidase EJC51_RS36880 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EJC51_RS36920 ENOG4105C7K acetolactate synthase EJC51_RS36950 ENOG4105DRR Transcriptional regulator, GntR family EJC51_RS36980 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EJC51_RS36985 ENOG4105C7N Xanthine uracil vitamin C permease EJC51_RS37005 ENOG4108ZJ4 polysaccharide deacetylase EJC51_RS37010 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EJC51_RS37020 ENOG4105DXX methyltransferase EJC51_RS37025 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EJC51_RS37030 ENOG41061H0 Monooxygenase EJC51_RS37035 ENOG4105CPQ Dehydrogenase EJC51_RS37040 ENOG4105CHR reductase EJC51_RS37070 ENOG4108TGC Acyltransferase EJC51_RS37090 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS37145 ENOG4105C57 major facilitator superfamily EJC51_RS37155 ENOG4108J2P Alpha beta hydrolase fold EJC51_RS37200 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EJC51_RS37210 ENOG4105KVH Transcriptional regulator EJC51_RS37220 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EJC51_RS37230 ENOG4105CUX Signal transduction histidine kinase EJC51_RS37240 ENOG4105D74 hydrolase EJC51_RS37245 ENOG4105E1F short-chain dehydrogenase reductase EJC51_RS37270 ENOG4105D7N magnesium and cobalt transport protein CorA EJC51_RS37280 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS37290 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap EJC51_RS37305 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJC51_RS37310 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS37315 ENOG4105XYF acetyltransferase EJC51_RS37325 ENOG41060W2 glyoxylate carboligase EJC51_RS37335 ENOG4105CH6 catalase EJC51_RS37340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJC51_RS37345 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EJC51_RS37365 ENOG4105VT2 5-hydroxyisourate hydrolase EJC51_RS37375 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS37400 ENOG4105KVH Transcriptional regulator EJC51_RS37415 ENOG4108ZM9 phosphoglycerate mutase EJC51_RS37440 ENOG4105DUU IucA IucC family protein EJC51_RS37445 ENOG4105DBM Siderophore biosynthesis protein EJC51_RS37460 ENOG4107R9S Malate synthase EJC51_RS37475 ENOG4107HP6 Transcriptional regulator EJC51_RS37485 ENOG4105DHG Allantoate amidinohydrolase EJC51_RS37490 ENOG4105F6U Short-chain dehydrogenase reductase Sdr EJC51_RS37540 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS37550 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJC51_RS37560 ENOG4105DKQ ROK family EJC51_RS37570 ENOG4105C0D helicase EJC51_RS37585 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EJC51_RS37590 ENOG4105E8R UPF0173 metal-dependent hydrolase EJC51_RS37610 ENOG4105CDA abc transporter atp-binding protein EJC51_RS37625 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EJC51_RS37660 ENOG4105C8Y Acetylornithine aminotransferase EJC51_RS37675 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) EJC51_RS37685 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EJC51_RS37700 ENOG4105BZU Histidine kinase EJC51_RS37705 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS37710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJC51_RS37720 ENOG4105ECY inositol monophosphatase EJC51_RS37730 ENOG4108UVJ appr-1-p processing domain protein EJC51_RS37755 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EJC51_RS37765 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EJC51_RS37770 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJC51_RS37780 ENOG4105BZW Glycerate kinase EJC51_RS37790 ENOG4108IV0 ABC, transporter EJC51_RS37795 ENOG4105C0Z ABC transporter EJC51_RS37800 ENOG4105C32 Amino acid ABC transporter (Permease) EJC51_RS37805 ENOG4105C32 Amino acid ABC transporter (Permease) EJC51_RS37820 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme EJC51_RS37825 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS37855 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS37875 ENOG4106JDR secreted EJC51_RS37905 ENOG4108ME1 Peptidase M55 D-aminopeptidase EJC51_RS37910 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EJC51_RS37920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJC51_RS37945 ENOG4107HQ7 repeat protein EJC51_RS37965 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJC51_RS37970 ENOG4105DIA mandelate racemase muconate lactonizing EJC51_RS37975 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJC51_RS37990 ENOG4105DQE DNA ligase EJC51_RS38000 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth EJC51_RS38025 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) EJC51_RS38035 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) EJC51_RS38050 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJC51_RS38065 ENOG4105C5H ABC transporter EJC51_RS38080 ENOG4105CH6 catalase EJC51_RS38085 ENOG4108Z0Z intracellular protease Pfpi family EJC51_RS38095 ENOG4105C2X Arabinose 5-phosphate isomerase EJC51_RS38165 ENOG4105CFG Acts as a chaperone (By similarity) EJC51_RS38175 ENOG4105R3A Nitrate reductase EJC51_RS38180 ENOG4108IUE nitrate reductase beta subunit EJC51_RS38210 ENOG410842T Pterin carbinolamine dehydratase EJC51_RS38230 ENOG4105D29 Helix-turn-helix type 11 domain protein EJC51_RS38235 ENOG4105CX8 fg-gap repeat protein EJC51_RS38245 ENOG4105CYP glycoside hydrolase, family EJC51_RS38250 ENOG41065HY 1,4-beta-cellobiosidase EJC51_RS38275 ENOG4108VB1 regulatoR EJC51_RS38280 ENOG4105CV8 reductase EJC51_RS38300 ENOG4105EMY transcriptional regulator EJC51_RS38305 ENOG4105DHU Bile acid EJC51_RS38315 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJC51_RS38325 ENOG4105D3W isochorismatase EJC51_RS38330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJC51_RS38340 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJC51_RS38350 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJC51_RS38365 ENOG4105DKQ ROK family EJC51_RS38370 ENOG4105C2J ABC transporter EJC51_RS38375 ENOG4105CNN ABC, transporter EJC51_RS38380 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJC51_RS38455 ENOG4105FCD Major Facilitator EJC51_RS38465 ENOG4105CMV Succinyl-CoA synthetase subunit beta EJC51_RS38475 ENOG4105C26 Dehydrogenase EJC51_RS38495 ENOG4108WYP Transcriptional regulator EJC51_RS38510 ENOG4108IEG Formate dehydrogenase Alpha subunit EJC51_RS38525 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS38530 ENOG4105CFN oxalyl-CoA decarboxylase EJC51_RS38535 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJC51_RS38555 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EJC51_RS38560 ENOG4105EGE secreted protein EJC51_RS38575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EJC51_RS38585 ENOG4105DQQ Major facilitator superfamily MFS_1 EJC51_RS38615 ENOG4107RRN ABC transporter substrate-binding protein EJC51_RS38630 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJC51_RS38645 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS38665 ENOG4107QJN gtp cyclohydrolase ii EJC51_RS38700 ENOG410905P Pyridoxamine 5-phosphate EJC51_RS38705 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EJC51_RS38710 ENOG4105CSH Transporter EJC51_RS38720 ENOG4107S9B Shikimate dehydrogenase EJC51_RS38725 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJC51_RS38750 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EJC51_RS38755 ENOG4108J5G 6-phosphogluconate dehydrogenase EJC51_RS38760 ENOG4107QP8 phosphohexose isomerase EJC51_RS38775 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJC51_RS38800 ENOG4107R13 MMPL domain protein EJC51_RS38810 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS38815 ENOG4105BZU Histidine kinase EJC51_RS38830 ENOG4105CHR reductase EJC51_RS38850 ENOG4105C4X radical SAM domain protein EJC51_RS38870 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EJC51_RS38890 ENOG41088CQ domain protein EJC51_RS38895 ENOG4105CNT hydrolase family 2 EJC51_RS38915 ENOG4108MGF sugar kinase EJC51_RS38925 ENOG4105F8D glycoside hydrolase family 4 EJC51_RS38940 ENOG4106UDK Cellulose-binding, family II EJC51_RS38995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS39000 ENOG4107TYH extracellular solute-binding protein family 1 EJC51_RS39005 ENOG4105D81 ABC transporter, permease EJC51_RS39010 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EJC51_RS39025 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS39030 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EJC51_RS39035 ENOG4105CG3 alpha amylase, catalytic region EJC51_RS39050 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJC51_RS39055 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJC51_RS39060 ENOG4105D2X ABC transporter substrate-binding protein EJC51_RS39125 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EJC51_RS39130 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EJC51_RS39135 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EJC51_RS39165 ENOG4105DQE DNA ligase EJC51_RS39190 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS39200 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) EJC51_RS39255 ENOG4106V2I dimethylaminohydrolase EJC51_RS39260 ENOG4105C5H ABC transporter EJC51_RS39275 ENOG4105KF0 sporulation and cell division protein, SsgA EJC51_RS39305 ENOG4105EG6 Saccharopine dehydrogenase EJC51_RS39310 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJC51_RS39315 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS39320 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS39325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJC51_RS39345 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) EJC51_RS39350 ENOG41066UZ arginase EC 3.5.3.1 EJC51_RS39365 ENOG4105C94 Transporter EJC51_RS39380 ENOG4105C5H ABC transporter EJC51_RS39385 ENOG4105BZM domain protein EJC51_RS39405 ENOG4105E39 Enoyl-CoA hydratase EJC51_RS39420 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EJC51_RS39445 ENOG4108MDK Dehydrogenase EJC51_RS39465 ENOG4105EY8 ABC transporter EJC51_RS39470 ENOG4105FBD synthase EJC51_RS39480 ENOG4107S11 squalene-associated FAD-dependent desaturase EJC51_RS39490 ENOG4105EWU Squalene--hopene cyclase EJC51_RS39505 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EJC51_RS39545 ENOG4105EKC EJC51_RS39560 ENOG41090WU lipolytic protein G-D-S-L family EJC51_RS39565 ENOG4105MPN Membrane EJC51_RS39635 ENOG4105CPQ Dehydrogenase EJC51_RS39640 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EJC51_RS39645 ENOG4106NZI LysR family Transcriptional regulator EJC51_RS39675 ENOG4105ECP epimerase EJC51_RS39680 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJC51_RS39685 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS39700 ENOG4108W5M transcriptional regulator EJC51_RS39705 ENOG4107AQZ Membrane EJC51_RS39715 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS39720 ENOG4105CMR udp-glucose 4-epimerase EJC51_RS39735 ENOG4105C5F glutamine synthetase EJC51_RS39755 ENOG4108IMY Transcriptional regulator EJC51_RS39760 ENOG4105H1N peptidase, M24 EJC51_RS39765 ENOG4107RUY (E1 component), alpha subunit EJC51_RS39775 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EJC51_RS39815 ENOG4105E5G Alpha beta hydrolase fold EJC51_RS39870 ENOG4105D3Q Sugar transferase EJC51_RS39875 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS39925 ENOG4105C1B dTDP-glucose 4-6-dehydratase EJC51_RS39930 ENOG4107QQG Dehydrogenase EJC51_RS39940 ENOG4108KGH TRANSCRIPTIONal EJC51_RS39945 ENOG4105BZP glycoside hydrolase 15-related EJC51_RS39950 ENOG4105C1J atp-dependent rna helicase EJC51_RS39955 ENOG4105VEQ Cold shock protein EJC51_RS39960 ENOG4107VIJ nudix hydrolase EJC51_RS39975 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EJC51_RS39980 ENOG4105EDK PfkB domain protein EJC51_RS39990 ENOG4105CNN ABC, transporter EJC51_RS39995 ENOG4105C2J ABC transporter EJC51_RS40005 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EJC51_RS40015 ENOG4105EE0 oxidoreductase EJC51_RS40025 ENOG4105CHR reductase EJC51_RS40035 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS40065 ENOG4105EQ2 LysR family Transcriptional regulator EJC51_RS40070 ENOG4108QBF Transcriptional regulator EJC51_RS40080 ENOG4105JSC dimethylmenaquinone methyltransferase EJC51_RS40100 ENOG4105C57 major facilitator superfamily EJC51_RS40130 ENOG4105DRP amino acid AbC transporter EJC51_RS40135 ENOG4105CDA abc transporter atp-binding protein EJC51_RS40140 ENOG4105EAB amino acid AbC transporter EJC51_RS40155 ENOG4105DEN Luciferase family EJC51_RS40160 ENOG4105DEN Luciferase family EJC51_RS40175 ENOG4106S2D Transcriptional regulator EJC51_RS40200 ENOG4106A3M Cytochrome p-450 EJC51_RS40225 ENOG4105E9K Isocitrate dehydrogenase EJC51_RS40235 ENOG4105D64 Mechanosensitive ion channel EJC51_RS40240 ENOG4105CUB amino acid EJC51_RS40250 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EJC51_RS40265 ENOG41060WC Enoyl-CoA hydratase EJC51_RS40280 ENOG4105BZ1 (ABC) transporter EJC51_RS40315 ENOG4105DRS transport system, permease EJC51_RS40320 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component EJC51_RS40330 ENOG4105C6F GntR Family Transcriptional Regulator EJC51_RS40335 ENOG4105D5P Methylmalonyl-coA mutase EJC51_RS40340 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EJC51_RS40355 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EJC51_RS40360 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) EJC51_RS40385 ENOG4107QPH glycogen) synthase EJC51_RS40390 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EJC51_RS40410 ENOG4108R85 Short chain dehydrogenase EJC51_RS40425 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJC51_RS40440 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS40485 ENOG41073TP transcriptional regulator EJC51_RS40490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJC51_RS40505 ENOG4105DIA mandelate racemase muconate lactonizing EJC51_RS40510 ENOG4105CHR reductase EJC51_RS40580 ENOG4105CRK lysyL-tRNA synthetase EJC51_RS40585 ENOG4108ZJ4 polysaccharide deacetylase EJC51_RS40625 ENOG4105BZU Histidine kinase EJC51_RS40635 ENOG4105C5Q Transcriptional regulator EJC51_RS40650 ENOG4105E33 succinate dehydrogenase EJC51_RS40680 ENOG4105DEN Luciferase family EJC51_RS40685 ENOG4105CKI cobalamin synthesis protein EJC51_RS40690 ENOG41068HZ 50S ribosomal protein L32 EJC51_RS40700 ENOG4105WKW Pfam:DUF1458 EJC51_RS40705 ENOG41067HS methyltransferase EJC51_RS40710 ENOG4108V75 Glutamine amidotransferase EJC51_RS40715 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process EJC51_RS40735 ENOG4105DZ6 Band 7 protein EJC51_RS40760 ENOG41089UC methyltransferase, type 11 EJC51_RS40805 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EJC51_RS40815 ENOG4105CV8 reductase EJC51_RS40855 ENOG4107RSM transcriptional regulator EJC51_RS40870 ENOG41060NJ transcriptional regulator EJC51_RS40875 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EJC51_RS40880 ENOG41080RH Thioredoxin EJC51_RS40890 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJC51_RS40915 ENOG4105EUB pirin domain protein EJC51_RS40940 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB EJC51_RS40950 ENOG4105C19 ABC transporter EJC51_RS40955 ENOG4105E90 ABC transporter EJC51_RS40960 ENOG4105E90 ABC transporter EJC51_RS40990 ENOG4108IJ8 ABC transporter EJC51_RS41000 ENOG41080R8 Conserved Protein EJC51_RS41010 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EJC51_RS41015 ENOG4105DET Rhamnulokinase EJC51_RS41030 ENOG4105C2J ABC transporter EJC51_RS41035 ENOG4105CNN ABC, transporter EJC51_RS41045 ENOG4105D4B ABC, transporter EJC51_RS41060 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS41075 ENOG4108KPJ rna polymerase sigma factor EJC51_RS41085 ENOG4105DDN Pentapeptide repeat-containing protein EJC51_RS41090 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EJC51_RS41095 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EJC51_RS41105 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJC51_RS41175 ENOG4105DCG PHP domain protein EJC51_RS41220 ENOG4105MKQ Monovalent cation H antiporter subunit C EJC51_RS41225 ENOG4105C8S subunit m EJC51_RS41245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EJC51_RS41265 ENOG4105C26 Dehydrogenase EJC51_RS41340 ENOG4105CUB amino acid EJC51_RS41360 ENOG4105CHF Glutathione S-transferase EJC51_RS41390 ENOG4106YKD Cytochrome p-450 EJC51_RS41415 ENOG4105CPC Aldo Keto reductase EJC51_RS41465 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJC51_RS41485 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJC51_RS41505 ENOG4108JQ1 Dehydrogenase EJC51_RS41510 ENOG4105DMF Dehydrogenase EJC51_RS41545 ENOG4108VQT Alpha beta hydrolase fold protein EJC51_RS41565 ENOG4108JJA ABC, transporter EJC51_RS41615 ENOG4105CJA serine threonine protein kinase EJC51_RS41625 ENOG4107V9E glucose-1-phosphate thymidylyltransferase EJC51_RS41655 ENOG4105XRQ Xanthine dehydrogenase accessory factor EJC51_RS41685 ENOG4105EX0 alpha-galactosidase EJC51_RS41695 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJC51_RS41710 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJC51_RS41735 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJC51_RS41745 ENOG4105C6X Major Facilitator EJC51_RS41755 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EJC51_RS41760 ENOG4108MES Periplasmic binding protein EJC51_RS41765 ENOG4105E0A ABC, transporter EJC51_RS41770 ENOG4105TVJ transport system, permease EJC51_RS41775 ENOG4105DQ5 transport system permease protein EJC51_RS41820 ENOG4105PDP Short chain dehydrogenase EJC51_RS41825 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EJC51_RS41860 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJC51_RS41865 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS41870 ENOG4105E2R ROK family EJC51_RS41910 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS41930 ENOG4105DRS transport system, permease EJC51_RS41935 ENOG4105C5I Dehydrogenase EJC51_RS41950 ENOG4106AM8 polysaccharide lyase family 8 EJC51_RS41995 ENOG41066F8 ROK family EJC51_RS42005 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EJC51_RS42010 ENOG4105DRS transport system, permease EJC51_RS42030 ENOG4105KVH Transcriptional regulator EJC51_RS42060 ENOG4105D9G High-affinity EJC51_RS42090 ENOG4105EYF MMPL domain protein EJC51_RS42120 ENOG4105D9R oxidoreductase EJC51_RS42125 ENOG4108FN7 Aldo keto reductase EJC51_RS42130 ENOG4105BZ1 (ABC) transporter EJC51_RS42145 ENOG4105ECQ AraC Family Transcriptional Regulator EJC51_RS42195 ENOG4105YVS arsR family transcriptional regulator EJC51_RS42200 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJC51_RS42225 ENOG4108ZBR Gcn5-related n-acetyltransferase EJC51_RS42255 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJC51_RS42280 ENOG4108MP6 LysR family Transcriptional regulator EJC51_RS42285 ENOG4105FQP Beta-lactamase EJC51_RS42295 ENOG4108KTG Membrane protein, drug metabolite transporter EJC51_RS42300 ENOG4105K56 Transcriptional regulator EJC51_RS42330 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS42350 ENOG4105F27 Major Facilitator EJC51_RS42375 ENOG4105C01 Dihydroxy-acid dehydratase EJC51_RS42380 ENOG4107HP6 Transcriptional regulator EJC51_RS42385 ENOG4105ERH Fumarylacetoacetate hydrolase EJC51_RS42390 ENOG4105CPQ Dehydrogenase EJC51_RS42400 ENOG4105C87 Aminotransferase class I and II EJC51_RS42445 ENOG4108J2P Alpha beta hydrolase fold EJC51_RS42460 ENOG4105PTV Nudix Hydrolase EJC51_RS42470 ENOG4108KPJ rna polymerase sigma factor EJC51_RS42490 ENOG4105BZU Histidine kinase EJC51_RS42495 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS42520 ENOG4108UKZ OsmC family EJC51_RS42535 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EJC51_RS42550 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS42560 ENOG4107R16 Multicopper oxidase EJC51_RS42575 ENOG4105C5Q Transcriptional regulator EJC51_RS42580 ENOG4105C6K Malic enzyme EJC51_RS42585 ENOG4105XPP Protein of unknown function (DUF1275) EJC51_RS42625 ENOG4105KKX ATPase associated with various cellular activities aaa_5 EJC51_RS42660 ENOG4107RDP Dehydrogenase EJC51_RS42680 ENOG4105D29 Helix-turn-helix type 11 domain protein EJC51_RS42710 ENOG4105CHR reductase EJC51_RS42745 ENOG4105F27 Major Facilitator EJC51_RS42775 ENOG4105BZU Histidine kinase EJC51_RS42780 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS42785 ENOG4107U9T Pfam:Ribonuclease_BN EJC51_RS42805 ENOG4105F1J Homogentisate 1,2-dioxygenase EJC51_RS42815 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJC51_RS42825 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS42835 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EJC51_RS42870 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EJC51_RS42875 ENOG4105ENE Histidine kinase EJC51_RS42880 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS42905 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS42920 ENOG4105HHS UPF0256 protein EJC51_RS42930 ENOG4105BZ1 (ABC) transporter EJC51_RS42940 ENOG4105KVH Transcriptional regulator EJC51_RS42975 ENOG4105VEQ Cold shock protein EJC51_RS43000 ENOG4105DKQ ROK family EJC51_RS43005 ENOG4105C2J ABC transporter EJC51_RS43010 ENOG4105CNN ABC, transporter EJC51_RS43015 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EJC51_RS43055 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) EJC51_RS43065 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EJC51_RS43080 ENOG4105ESN nucleotide-binding protein EJC51_RS43105 ENOG4107RSM transcriptional regulator EJC51_RS43110 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS43120 ENOG4107QNJ CoA-transferase subunit B EJC51_RS43125 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS43130 ENOG4105BZU Histidine kinase EJC51_RS43135 ENOG4105EYF MMPL domain protein EJC51_RS43140 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EJC51_RS43150 ENOG4107RN3 metallophosphoesterase EJC51_RS43170 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS43180 ENOG4105C5F glutamine synthetase EJC51_RS43195 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) EJC51_RS43235 ENOG4105C26 Dehydrogenase EJC51_RS43240 ENOG4108Z86 Glutamine amidotransferase EJC51_RS43245 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EJC51_RS43255 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EJC51_RS43265 ENOG4105GVJ transcriptional regulator EJC51_RS43285 ENOG410880H cysteine synthase EJC51_RS43295 ENOG4108M4U conserved membrane protein EJC51_RS43330 ENOG4105EXC Acyl-transferase EJC51_RS43340 ENOG4108M8W Monooxygenase EJC51_RS43345 ENOG4105KVH Transcriptional regulator EJC51_RS43350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EJC51_RS43390 ENOG4107HP6 Transcriptional regulator EJC51_RS43425 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS43445 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJC51_RS43460 ENOG4107R13 MMPL domain protein EJC51_RS43470 ENOG4107EEY synthase EJC51_RS43480 ENOG4105C1G acyl-Coa dehydrogenase EJC51_RS43525 ENOG4105EMN RNA polymerase sigma factor EJC51_RS43535 ENOG4105ESF Peptidoglycan binding domain protein EJC51_RS43560 ENOG4105DF9 Lipoate-protein, ligase EJC51_RS43565 ENOG4108HMN Caspase domain EJC51_RS43590 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EJC51_RS43595 ENOG4105JAB phenazine biosynthesis protein, phzf family EJC51_RS43620 ENOG4108YIQ Alpha beta hydrolase EJC51_RS43630 ENOG4105E8R UPF0173 metal-dependent hydrolase EJC51_RS43675 ENOG4108W5M transcriptional regulator EJC51_RS43720 ENOG41082BM Transcriptional regulator, arsr family EJC51_RS43730 ENOG4108Z7F N-acetyltransferase EJC51_RS43735 ENOG4107RSM transcriptional regulator EJC51_RS43740 ENOG4105EMU Dehydrogenase EJC51_RS43775 ENOG4105KVH Transcriptional regulator EJC51_RS43780 ENOG4106KE4 Dehydrogenase EJC51_RS43810 ENOG4105EBR Carboxylesterase EJC51_RS43815 ENOG4105DRS transport system, permease EJC51_RS43820 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS43835 ENOG4105CHR reductase EJC51_RS43840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJC51_RS43845 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EJC51_RS43850 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJC51_RS43870 ENOG4105CPC Aldo Keto reductase EJC51_RS43895 ENOG4105EQ0 Major Facilitator superfamily EJC51_RS43910 ENOG4105C6Z Gluconate EJC51_RS43920 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJC51_RS43925 ENOG4108MRH transcriptional regulatory protein EJC51_RS43945 ENOG4105PDP Short chain dehydrogenase EJC51_RS43950 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJC51_RS43960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS43970 ENOG4105DEF Extracellular solute-binding protein, family 5 EJC51_RS43975 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone EJC51_RS44060 ENOG4105CHR reductase EJC51_RS44090 ENOG4105DRS transport system, permease EJC51_RS44100 ENOG4107FKK extracellular solute-binding protein family 1 EJC51_RS44110 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS44145 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EJC51_RS44165 ENOG4107RQ0 Maleylacetate reductase EJC51_RS44205 ENOG4105C6F GntR Family Transcriptional Regulator EJC51_RS44225 ENOG4108W6C Dehydrogenase EJC51_RS44240 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJC51_RS44280 ENOG4108PC0 lipolytic protein G-D-S-L family EJC51_RS44300 ENOG4106UW1 Major Facilitator superfamily EJC51_RS44305 ENOG4105H3G oxidoreductase EJC51_RS44315 ENOG4105C26 Dehydrogenase EJC51_RS44320 ENOG4108ZX5 transcriptional regulator EJC51_RS44335 ENOG4105CPC Aldo Keto reductase EJC51_RS44360 ENOG41065HY 1,4-beta-cellobiosidase EJC51_RS44365 ENOG4105CYP glycoside hydrolase, family EJC51_RS44370 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) EJC51_RS44375 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS44405 ENOG4105FP9 thiamine pyrophosphate EJC51_RS44445 ENOG4105EZR dyp-type peroxidase family protein EJC51_RS44480 ENOG4105CIR epoxide hydrolase EJC51_RS44505 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJC51_RS44520 ENOG4107MMM Anti-sigma-factor antagonist EJC51_RS44525 ENOG4105FUA antagonist EJC51_RS44530 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EJC51_RS44560 ENOG4105WN5 stage II sporulation protein EJC51_RS44565 ENOG4105BZU Histidine kinase EJC51_RS44610 ENOG4108IND Tetr family transcriptional regulator EJC51_RS44625 ENOG4105YA8 Transcriptional regulator EJC51_RS44650 ENOG4108IG5 Transcriptional regulator EJC51_RS44680 ENOG4105KVH Transcriptional regulator EJC51_RS44685 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) EJC51_RS44690 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EJC51_RS44695 ENOG4108Z6Z Transcriptional regulator EJC51_RS44715 ENOG4108Z6Z Transcriptional regulator EJC51_RS44720 ENOG4105EMU Dehydrogenase EJC51_RS44725 ENOG4105EYF MMPL domain protein EJC51_RS44735 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJC51_RS44740 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EJC51_RS44745 ENOG4105ERH Fumarylacetoacetate hydrolase EJC51_RS44770 ENOG4105C57 major facilitator superfamily EJC51_RS44880 ENOG4105EX0 alpha-galactosidase EJC51_RS44945 ENOG4108Z6Z Transcriptional regulator EJC51_RS44955 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS44960 ENOG4105BZU Histidine kinase EJC51_RS44965 ENOG4105EYF MMPL domain protein EJC51_RS44970 ENOG4105EYF MMPL domain protein EJC51_RS44975 ENOG41062D9 Histidine kinase EJC51_RS44980 ENOG4105ETX regulatoR EJC51_RS44990 ENOG4105EHG Permease protein EJC51_RS44995 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EJC51_RS45005 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EJC51_RS45035 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EJC51_RS45045 ENOG4108W5M transcriptional regulator EJC51_RS45050 ENOG4105CHR reductase EJC51_RS45110 ENOG4107RSM transcriptional regulator EJC51_RS45125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJC51_RS45160 ENOG4106A3M Cytochrome p-450 EJC51_RS45185 ENOG4108S01 response regulator EJC51_RS45195 ENOG4105EC3 peptidase S51, dipeptidase E EJC51_RS45205 ENOG4105WQT MbtH domain protein EJC51_RS45220 ENOG4105C7B Threonine dehydratase EJC51_RS45225 ENOG4105CEY Amp-dependent synthetase and ligase EJC51_RS45235 ENOG4108JQ7 (ABC) transporter EJC51_RS45250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJC51_RS45265 ENOG41073TP transcriptional regulator EJC51_RS45275 ENOG4105MSB protein, conserved in bacteria EJC51_RS45295 ENOG4105EBR Carboxylesterase EJC51_RS45305 ENOG4105ECR NmrA family EJC51_RS45460 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJC51_RS45485 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJC51_RS45490 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) EJC51_RS45625 ENOG41067XF inhibitor EJC51_RS45705 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EJC51_RS45745 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJC51_RS45755 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EJC51_RS45760 ENOG4108IXY short-chain dehydrogenase reductase EJC51_RS45775 ENOG4108JQ1 Dehydrogenase EJC51_RS45810 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJC51_RS45825 ENOG4105CHR reductase EJC51_RS45840 ENOG4105C26 Dehydrogenase EJC51_RS45845 ENOG4105CHR reductase EJC51_RS45875 ENOG410667J hydrolase EJC51_RS45895 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F EJC51_RS45900 ENOG4108KEZ Dehydrogenase EJC51_RS45910 ENOG4105YA8 Transcriptional regulator EJC51_RS45945 ENOG4105CHR reductase EJC51_RS45970 ENOG4107RQ0 Maleylacetate reductase EJC51_RS46005 ENOG4108SGK Tetr family transcriptional regulator EJC51_RS46015 ENOG4107RSM transcriptional regulator EJC51_RS46020 ENOG4105CHU acetyl-coa acetyltransferase EJC51_RS46030 ENOG4107QNJ CoA-transferase subunit B EJC51_RS46260 ENOG4108HMN Caspase domain EJC51_RS46295 ENOG4105ETE Transcriptional regulator (LacI family EJC51_RS46300 ENOG4107T3P ABC, transporter EJC51_RS46315 ENOG4105CG3 alpha amylase, catalytic region EJC51_RS46345 ENOG4105BZU Histidine kinase EJC51_RS46420 ENOG4105CPC Aldo Keto reductase EJC51_RS46530 ENOG4108FKE two-component system sensor kinase EJC51_RS46555 ENOG4105BZU Histidine kinase EJC51_RS46560 ENOG4105WH1 Two component transcriptional regulator luxr family EJC51_RS46595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EJC51_RS46610 ENOG4105ES5 Histidine kinase EJC51_RS46625 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EJC51_RS46630 ENOG4105D7T ABC transporter EJC51_RS46635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJC51_RS46640 ENOG4108MRH transcriptional regulatory protein EJC51_RS46650 ENOG4106F60 Histidine kinase EJC51_RS46655 ENOG4105ETX regulatoR EJC51_RS46660 ENOG410841Q phosphoesterase PA-phosphatase related protein EJC51_RS46665 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJC51_RS46680 ENOG4107QI1 Mate efflux family protein EJC51_RS46710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJC51_RS46715 ENOG4108EU3 peptide transport system, permease EJC51_RS46720 ENOG4108JQ6 ABC transporter EJC51_RS46725 ENOG4108ZJ4 polysaccharide deacetylase EJC51_RS46730 ENOG4108QBV Monogalactosyldiacylglycerol synthase EJC51_RS46775 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EJC51_RS46780 ENOG4107UUT deoxycytidine triphosphate deaminase EJC51_RS46785 ENOG4107S9R deoxycytidine triphosphate deaminase EJC51_RS46795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EJC51_RS46875 ENOG4105C57 major facilitator superfamily EJC51_RS46910 ENOG4107QN1 sodium solute EJC51_RS46920 ENOG4107HP6 Transcriptional regulator EJC51_RS46930 ENOG4105IKQ hydratase EJC51_RS46935 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) EJC51_RS46940 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) EJC51_RS46955 ENOG4105CJ1 ABC, transporter EJC51_RS46965 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EJC51_RS47005 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJC51_RS47105 ENOG4105PAD Hydrolase EJC51_RS47180 ENOG4105BZU Histidine kinase EJC51_RS47220 ENOG4105FDF Could be involved in DNA repair (By similarity) EJC51_RS47300 ENOG4105DQE DNA ligase EJC51_RS47330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJC51_RS47340 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase