locus-tag	class	description
C5746_RS00035	COG3655	Transcriptional regulator
C5746_RS00195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5746_RS00220	COG0789	Transcriptional regulator
C5746_RS00260	COG2755	lipolytic protein G-D-S-L family
C5746_RS00315	COG0395	ABC-type sugar transport system, permease component
C5746_RS00325	COG1609	Transcriptional regulator
C5746_RS00440	COG0488	(ABC) transporter
C5746_RS00445	COG0488	(ABC) transporter
C5746_RS00475	COG0154	amidase activity
C5746_RS00500	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS00510	COG2409	Drug exporters of the RND superfamily
C5746_RS00515	COG4585	Histidine kinase
C5746_RS00520	COG2197	response regulator
C5746_RS00650	COG1051	belongs to the nudix hydrolase family
C5746_RS00670	COG2130	NADP-dependent
C5746_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS00760	COG1309	transcriptional regulator
C5746_RS00805	COG2945	thiolester hydrolase activity
C5746_RS00805	COG0596	Alpha beta hydrolase
C5746_RS00840	COG2814	Major facilitator Superfamily
C5746_RS00855	COG0656	L-ascorbic acid biosynthetic process
C5746_RS00860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS00930	COG1132	(ABC) transporter
C5746_RS00995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5746_RS01010	COG1131	(ABC) transporter
C5746_RS01015	COG3851	Histidine kinase
C5746_RS01020	COG2197	response regulator
C5746_RS01040	COG2197	response regulator
C5746_RS01080	COG2132	Multicopper oxidase
C5746_RS01190	COG2801	Transposase and inactivated derivatives
C5746_RS01245	COG4948	Mandelate Racemase Muconate Lactonizing
C5746_RS01250	COG1609	Transcriptional regulator
C5746_RS01255	COG1653	transport
C5746_RS01260	COG1175	transmembrane transport
C5746_RS01265	COG0395	ABC-type sugar transport system, permease component
C5746_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5746_RS01330	COG1222	aaa ATPase
C5746_RS01340	COG1506	peptidase
C5746_RS01340	COG0823	Involved in the tonB-independent uptake of proteins
C5746_RS01435	COG4977	sequence-specific DNA binding
C5746_RS01480	COG3903	Transcriptional regulator
C5746_RS01480	COG2197	response regulator
C5746_RS01515	COG3629	intracellular signal transduction
C5746_RS01515	COG3903	Transcriptional regulator
C5746_RS01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5746_RS01560	COG2124	cytochrome p450
C5746_RS01595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS01615	COG2124	cytochrome p450
C5746_RS01645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5746_RS01665	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C5746_RS01680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS01710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5746_RS01730	COG0577	efflux transmembrane transporter activity
C5746_RS01730	COG1136	(ABC) transporter
C5746_RS01745	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS01790	COG0587	DNA-directed DNA polymerase activity
C5746_RS01815	COG1404	Belongs to the peptidase S8 family
C5746_RS01855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5746_RS01900	COG2826	transposase and inactivated derivatives, IS30 family
C5746_RS01905	COG0515	serine threonine protein kinase
C5746_RS01905	COG2815	serine threonine protein kinase
C5746_RS01910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5746_RS01920	COG0798	PFAM Bile acid sodium symporter
C5746_RS01930	COG1335	isochorismatase
C5746_RS01945	COG0583	DNA-binding transcription factor activity
C5746_RS01960	COG0590	tRNA wobble adenosine to inosine editing
C5746_RS01965	COG1132	(ABC) transporter
C5746_RS01985	COG0351	phosphomethylpyrimidine kinase
C5746_RS01990	COG0352	thiamine-phosphate diphosphorylase activity
C5746_RS01995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C5746_RS02020	COG1595	DNA-templated transcription, initiation
C5746_RS02150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5746_RS02175	COG3585	molybdate ion transport
C5746_RS02235	COG2197	response regulator
C5746_RS02285	COG0367	asparagine synthase
C5746_RS02295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5746_RS02300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5746_RS02305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5746_RS02345	COG1278	Cold shock
C5746_RS02355	COG3226	Transcriptional regulator
C5746_RS02455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5746_RS02465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5746_RS02470	COG0531	amino acid
C5746_RS02535	COG2826	transposase and inactivated derivatives, IS30 family
C5746_RS02545	COG2963	transposase activity
C5746_RS02575	COG0302	gtp cyclohydrolase
C5746_RS02580	COG0602	queuosine metabolic process
C5746_RS02595	COG1309	transcriptional regulator
C5746_RS02730	COG0768	penicillin binding
C5746_RS02740	COG0714	Associated with various cellular activities
C5746_RS02745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5746_RS02765	COG1764	response to oxidative stress
C5746_RS02770	COG1846	Transcriptional regulator
C5746_RS02835	COG1846	Transcriptional regulator
C5746_RS02840	COG2318	DinB family
C5746_RS02855	COG0254	rRNA binding
C5746_RS02860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5746_RS02890	COG4213	ABC transporter substrate-binding protein
C5746_RS02900	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5746_RS02905	COG1129	ABC transporter
C5746_RS02910	COG1940	carbohydrate kinase activity
C5746_RS02910	COG1846	Transcriptional regulator
C5746_RS02960	COG2807	transmembrane transport
C5746_RS02965	COG2186	Transcriptional regulator
C5746_RS03005	COG1024	Enoyl-CoA hydratase
C5746_RS03030	COG2867	negative regulation of translational initiation
C5746_RS03040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS03050	COG0662	Cupin 2, conserved barrel domain protein
C5746_RS03075	COG0542	response to heat
C5746_RS03080	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS03105	COG2070	2-Nitropropane dioxygenase
C5746_RS03110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5746_RS03135	COG1609	Transcriptional regulator
C5746_RS03140	COG2182	Extracellular solute-binding protein
C5746_RS03145	COG1175	transmembrane transport
C5746_RS03150	COG0395	ABC-type sugar transport system, permease component
C5746_RS03190	COG3458	cephalosporin-C deacetylase activity
C5746_RS03200	COG2815	serine threonine protein kinase
C5746_RS03200	COG0515	serine threonine protein kinase
C5746_RS03215	COG2326	polyphosphate kinase activity
C5746_RS03230	COG0516	GMP reductase activity
C5746_RS03230	COG0517	IMP dehydrogenase activity
C5746_RS03245	COG1960	acyl-CoA dehydrogenase activity
C5746_RS03250	COG2813	Specifically methylates the guanine in position
C5746_RS03260	COG2356	endonuclease I
C5746_RS03265	COG2066	Belongs to the glutaminase family
C5746_RS03265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C5746_RS03290	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5746_RS03305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5746_RS03310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5746_RS03315	COG2080	2 iron, 2 sulfur cluster binding
C5746_RS03365	COG2365	Tyrosine phosphatase family
C5746_RS03405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5746_RS03410	COG0667	Aldo Keto reductase
C5746_RS03420	COG1252	NADH dehydrogenase
C5746_RS03430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5746_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS03445	COG0435	Glutathione S-transferase
C5746_RS03455	COG2223	nitrite transmembrane transporter activity
C5746_RS03465	COG2146	nitrite reductase [NAD(P)H] activity
C5746_RS03465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5746_RS03470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5746_RS03475	COG0243	molybdopterin cofactor binding
C5746_RS03480	COG0745	RESPONSE REGULATOR receiver
C5746_RS03510	COG4991	sh3 domain protein
C5746_RS03510	COG3103	Sh3 type 3 domain protein
C5746_RS03510	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5746_RS03535	COG3835	regulator
C5746_RS03555	COG2376	Dihydroxyacetone kinase
C5746_RS03560	COG1461	Dihydroxyacetone kinase
C5746_RS03585	COG0501	Belongs to the peptidase M48B family
C5746_RS03595	COG0586	Pfam SNARE associated Golgi protein
C5746_RS03600	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS03605	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS03650	COG1191	sigma factor activity
C5746_RS03675	COG1120	ATPase activity
C5746_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS03705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS03735	COG2814	Major facilitator Superfamily
C5746_RS03765	COG0842	Transport permease protein
C5746_RS03765	COG1716	ATPase activity
C5746_RS03765	COG1131	(ABC) transporter
C5746_RS03815	COG1960	acyl-CoA dehydrogenase activity
C5746_RS03835	COG3608	succinylglutamate desuccinylase aspartoacylase
C5746_RS03835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5746_RS03860	COG0277	FAD linked oxidase domain protein
C5746_RS03865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5746_RS03870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5746_RS03875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5746_RS03900	COG0438	transferase activity, transferring glycosyl groups
C5746_RS03915	COG0489	protein tyrosine kinase activity
C5746_RS03920	COG0297	glycogen (starch) synthase activity
C5746_RS03935	COG0328	RNA-DNA hybrid ribonuclease activity
C5746_RS03950	COG2188	Transcriptional regulator
C5746_RS03965	COG2815	serine threonine protein kinase
C5746_RS03965	COG0515	serine threonine protein kinase
C5746_RS04000	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS04025	COG0765	amino acid transport
C5746_RS04030	COG1126	abc transporter atp-binding protein
C5746_RS04035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5746_RS04045	COG0583	DNA-binding transcription factor activity
C5746_RS04055	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS04060	COG1940	carbohydrate kinase activity
C5746_RS04080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS04130	COG2084	Dehydrogenase
C5746_RS04220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5746_RS04240	COG0006	proline dipeptidase activity
C5746_RS04295	COG1609	Transcriptional regulator
C5746_RS04365	COG1063	alcohol dehydrogenase
C5746_RS04370	COG0657	acetylesterase activity
C5746_RS04440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5746_RS04445	COG1228	amidohydrolase
C5746_RS04450	COG2197	response regulator
C5746_RS04475	COG1609	Transcriptional regulator
C5746_RS04480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS04490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5746_RS04600	COG1595	DNA-templated transcription, initiation
C5746_RS04685	COG1454	alcohol dehydrogenase
C5746_RS04690	COG0126	phosphoglycerate kinase activity
C5746_RS04695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5746_RS04700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5746_RS04725	COG0673	inositol 2-dehydrogenase activity
C5746_RS04750	COG0395	ABC-type sugar transport system, permease component
C5746_RS04755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS04760	COG1940	carbohydrate kinase activity
C5746_RS04765	COG1105	Belongs to the carbohydrate kinase PfkB family
C5746_RS04810	COG1404	Belongs to the peptidase S8 family
C5746_RS04835	COG0395	ABC-type sugar transport system, permease component
C5746_RS04840	COG1470	cell adhesion involved in biofilm formation
C5746_RS04840	COG0366	Alpha amylase catalytic
C5746_RS04875	COG0596	Alpha beta hydrolase
C5746_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5746_RS04915	COG2372	response to copper ion
C5746_RS05005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5746_RS05030	COG0154	amidase activity
C5746_RS05080	COG1302	Protein conserved in bacteria
C5746_RS05235	COG2124	cytochrome p450
C5746_RS05240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS05260	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C5746_RS05265	COG2124	cytochrome p450
C5746_RS05285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5746_RS05290	COG3251	PFAM MbtH domain protein
C5746_RS05300	COG0604	alcohol dehydrogenase
C5746_RS05300	COG3321	synthase
C5746_RS05305	COG2124	cytochrome p450
C5746_RS05310	COG2267	carboxylic ester hydrolase activity
C5746_RS05330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5746_RS05330	COG0574	Belongs to the PEP-utilizing enzyme family
C5746_RS05335	COG0640	Transcriptional regulator
C5746_RS05370	COG1349	DNA-binding transcription factor activity
C5746_RS05380	COG0702	epimerase
C5746_RS05405	COG0577	efflux transmembrane transporter activity
C5746_RS05410	COG1136	(ABC) transporter
C5746_RS05425	COG1940	carbohydrate kinase activity
C5746_RS05430	COG2223	nitrite transmembrane transporter activity
C5746_RS05455	COG2197	response regulator
C5746_RS05460	COG4585	Histidine kinase
C5746_RS05520	COG3344	reverse transcriptase
C5746_RS05550	COG2801	Transposase and inactivated derivatives
C5746_RS05575	COG0395	ABC-type sugar transport system, permease component
C5746_RS05580	COG1175	transmembrane transport
C5746_RS05590	COG3345	alpha-galactosidase
C5746_RS05615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5746_RS05665	COG0584	glycerophosphoryl diester phosphodiesterase
C5746_RS05695	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS05720	COG0640	Transcriptional regulator
C5746_RS05790	COG1902	pentaerythritol trinitrate reductase activity
C5746_RS05820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5746_RS05835	COG2706	6-phosphogluconolactonase activity
C5746_RS05865	COG2815	serine threonine protein kinase
C5746_RS05865	COG0515	serine threonine protein kinase
C5746_RS05895	COG0586	Pfam SNARE associated Golgi protein
C5746_RS05900	COG4585	Histidine kinase
C5746_RS05905	COG2197	response regulator
C5746_RS05935	COG0438	transferase activity, transferring glycosyl groups
C5746_RS05940	COG0275	rRNA processing
C5746_RS05945	COG2197	response regulator
C5746_RS05985	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5746_RS05995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5746_RS06025	COG1653	transport
C5746_RS06050	COG1881	PFAM PEBP family protein
C5746_RS06055	COG1618	nucleotide phosphatase activity, acting on free nucleotides
C5746_RS06075	COG2072	flavoprotein involved in K transport
C5746_RS06085	COG1132	(ABC) transporter
C5746_RS06090	COG1846	Transcriptional regulator
C5746_RS06095	COG0277	FAD linked oxidase domain protein
C5746_RS06110	COG1132	(ABC) transporter
C5746_RS06115	COG0515	serine threonine protein kinase
C5746_RS06115	COG2815	serine threonine protein kinase
C5746_RS06235	COG1396	sequence-specific DNA binding
C5746_RS06245	COG0386	Belongs to the glutathione peroxidase family
C5746_RS06250	COG1960	acyl-CoA dehydrogenase activity
C5746_RS06260	COG0242	peptide deformylase activity
C5746_RS06270	COG3442	glutamine amidotransferase
C5746_RS06275	COG0205	6-phosphofructokinase activity
C5746_RS06305	COG3540	Alkaline phosphatase
C5746_RS06310	COG3250	beta-galactosidase activity
C5746_RS06325	COG0395	ABC-type sugar transport system, permease component
C5746_RS06335	COG0531	amino acid
C5746_RS06340	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C5746_RS06340	COG3408	Glycogen debranching enzyme
C5746_RS06350	COG0395	ABC-type sugar transport system, permease component
C5746_RS06365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5746_RS06370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5746_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS06385	COG1802	Transcriptional regulator
C5746_RS06390	COG0204	Acyl-transferase
C5746_RS06405	COG0829	nickel cation binding
C5746_RS06410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5746_RS06420	COG0804	urea catabolic process
C5746_RS06425	COG0832	Belongs to the urease beta subunit family
C5746_RS06430	COG0831	urea catabolic process
C5746_RS06435	COG1309	transcriptional regulator
C5746_RS06450	COG2957	Belongs to the agmatine deiminase family
C5746_RS06455	COG4608	Belongs to the ABC transporter superfamily
C5746_RS06475	COG1793	dna ligase
C5746_RS06480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5746_RS06500	COG0596	Alpha beta hydrolase
C5746_RS06650	COG1309	transcriptional regulator
C5746_RS06675	COG0740	serine-type endopeptidase activity
C5746_RS06690	COG1280	lysine exporter protein (LysE YggA)
C5746_RS06695	COG0583	DNA-binding transcription factor activity
C5746_RS06715	COG0156	8-amino-7-oxononanoate synthase activity
C5746_RS06720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5746_RS06725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5746_RS06730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5746_RS06735	COG2226	methyltransferase
C5746_RS06750	COG1366	Belongs to the anti-sigma-factor antagonist family
C5746_RS06750	COG2172	sigma factor antagonist activity
C5746_RS06750	COG2208	phosphoserine phosphatase activity
C5746_RS06770	COG1280	lysine exporter protein (LysE YggA)
C5746_RS06780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5746_RS06805	COG4585	Histidine kinase
C5746_RS06810	COG2197	response regulator
C5746_RS06815	COG1940	carbohydrate kinase activity
C5746_RS06820	COG2188	Transcriptional regulator
C5746_RS06890	COG1595	DNA-templated transcription, initiation
C5746_RS06895	COG2267	carboxylic ester hydrolase activity
C5746_RS06920	COG0626	cystathionine gamma-synthase activity
C5746_RS06940	COG0419	ATPase involved in DNA repair
C5746_RS06945	COG0420	3'-5' exonuclease activity
C5746_RS06955	COG1739	Uncharacterized protein family UPF0029
C5746_RS06960	COG1832	CoA-binding protein
C5746_RS07025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5746_RS07035	COG1968	undecaprenyl-diphosphatase activity
C5746_RS07070	COG0601	transmembrane transport
C5746_RS07120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5746_RS07180	COG0723	plastoquinol--plastocyanin reductase activity
C5746_RS07200	COG0697	spore germination
C5746_RS07250	COG1695	Transcriptional regulator
C5746_RS07300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5746_RS07300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5746_RS07310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5746_RS07330	COG1716	ATPase activity
C5746_RS07350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5746_RS07385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5746_RS07395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5746_RS07410	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C5746_RS07440	COG2018	Roadblock/LC7 domain
C5746_RS07500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5746_RS07505	COG2364	Membrane
C5746_RS07515	COG2270	Major facilitator Superfamily
C5746_RS07530	COG1216	Glycosyl transferase, family 2
C5746_RS07535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS07555	COG1960	acyl-CoA dehydrogenase activity
C5746_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS07585	COG3387	PFAM Glycoside hydrolase 15-related
C5746_RS07595	COG1595	DNA-templated transcription, initiation
C5746_RS07635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5746_RS07640	COG0140	phosphoribosyl-ATP diphosphatase activity
C5746_RS07645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5746_RS07650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5746_RS07650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5746_RS07655	COG3201	nicotinamide mononucleotide transporter
C5746_RS07680	COG1846	Transcriptional regulator
C5746_RS07680	COG1940	carbohydrate kinase activity
C5746_RS07685	COG0738	Major facilitator superfamily
C5746_RS07690	COG2233	PERMEase
C5746_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS07715	COG4948	Mandelate Racemase Muconate Lactonizing
C5746_RS07720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5746_RS07740	COG0673	inositol 2-dehydrogenase activity
C5746_RS07755	COG0395	ABC-type sugar transport system, permease component
C5746_RS07770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5746_RS07775	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5746_RS07785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5746_RS07795	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS07805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5746_RS07810	COG2390	Transcriptional regulator
C5746_RS07815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5746_RS07825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5746_RS07840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5746_RS07850	COG1758	RNA polymerase activity
C5746_RS07865	COG0284	orotidine-5'-phosphate decarboxylase activity
C5746_RS07870	COG0167	dihydroorotate dehydrogenase activity
C5746_RS07875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5746_RS07880	COG0505	Belongs to the CarA family
C5746_RS07890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS07895	COG0540	Belongs to the ATCase OTCase family
C5746_RS07900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5746_RS07910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5746_RS07915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5746_RS07920	COG0006	proline dipeptidase activity
C5746_RS07930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5746_RS07935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5746_RS07940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5746_RS07945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5746_RS07950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5746_RS07955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5746_RS07960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5746_RS07980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5746_RS08010	COG0124	histidyl-tRNA synthetase
C5746_RS08025	COG1196	nuclear chromosome segregation
C5746_RS08030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5746_RS08035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5746_RS08040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5746_RS08045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5746_RS08055	COG2255	four-way junction helicase activity
C5746_RS08060	COG0632	four-way junction helicase activity
C5746_RS08065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5746_RS08070	COG0217	transcriptional regulatory protein
C5746_RS08075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C5746_RS08080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C5746_RS08090	COG0438	transferase activity, transferring glycosyl groups
C5746_RS08095	COG1560	Kdo2-lipid A biosynthetic process
C5746_RS08100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5746_RS08120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5746_RS08125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5746_RS08140	COG2176	DNA-directed DNA polymerase activity
C5746_RS08140	COG5002	protein histidine kinase activity
C5746_RS08180	COG1609	Transcriptional regulator
C5746_RS08195	COG0456	acetyltransferase
C5746_RS08195	COG0454	-acetyltransferase
C5746_RS08205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5746_RS08205	COG0512	Glutamine amidotransferase of anthranilate synthase
C5746_RS08260	COG1648	precorrin-2 dehydrogenase activity
C5746_RS08260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5746_RS08265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5746_RS08280	COG1464	Belongs to the NlpA lipoprotein family
C5746_RS08285	COG2011	ABC-type metal ion transport system permease component
C5746_RS08330	COG0477	Major facilitator Superfamily
C5746_RS08345	COG1595	DNA-templated transcription, initiation
C5746_RS08355	COG0165	Argininosuccinate lyase
C5746_RS08360	COG0137	argininosuccinate synthase activity
C5746_RS08375	COG1438	arginine binding
C5746_RS08380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5746_RS08385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5746_RS08390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5746_RS08395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5746_RS08400	COG3387	PFAM Glycoside hydrolase 15-related
C5746_RS08420	COG0697	spore germination
C5746_RS08430	COG1649	PFAM Uncharacterised BCR, COG1649
C5746_RS08450	COG0072	phenylalanine-tRNA ligase activity
C5746_RS08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5746_RS08455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5746_RS08460	COG5002	protein histidine kinase activity
C5746_RS08475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5746_RS08480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5746_RS08485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5746_RS08490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5746_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS08540	COG0174	glutamine synthetase
C5746_RS08550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5746_RS08580	COG0517	IMP dehydrogenase activity
C5746_RS08580	COG4175	Glycine betaine
C5746_RS08585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5746_RS08620	COG1595	DNA-templated transcription, initiation
C5746_RS08650	COG1397	ADP-ribosylglycohydrolase
C5746_RS08680	COG0805	protein transport
C5746_RS08685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5746_RS08705	COG2378	regulation of single-species biofilm formation
C5746_RS08715	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5746_RS08720	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5746_RS08730	COG1609	Transcriptional regulator
C5746_RS08735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5746_RS08740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5746_RS08755	COG4122	O-methyltransferase activity
C5746_RS08760	COG1222	aaa ATPase
C5746_RS08785	COG1994	Peptidase M50
C5746_RS08785	COG0517	IMP dehydrogenase activity
C5746_RS08795	COG2197	response regulator
C5746_RS08800	COG0747	negative chemotaxis
C5746_RS08810	COG1410	methionine synthase
C5746_RS08810	COG0646	methionine synthase
C5746_RS08815	COG1414	Transcriptional regulator
C5746_RS08820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5746_RS08825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5746_RS08830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5746_RS08835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS08840	COG2186	Transcriptional regulator
C5746_RS08845	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5746_RS08850	COG1129	ABC transporter
C5746_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS08865	COG4948	Mandelate Racemase Muconate Lactonizing
C5746_RS08880	COG0215	cysteine-tRNA ligase activity
C5746_RS08900	COG0598	Magnesium transport protein CorA
C5746_RS08910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS08915	COG0667	Aldo Keto reductase
C5746_RS08945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5746_RS08960	COG0564	pseudouridine synthase activity
C5746_RS08980	COG0531	amino acid
C5746_RS08990	COG2186	Transcriptional regulator
C5746_RS08995	COG3265	gluconokinase activity
C5746_RS09055	COG3629	intracellular signal transduction
C5746_RS09055	COG3903	Transcriptional regulator
C5746_RS09060	COG0737	Belongs to the 5'-nucleotidase family
C5746_RS09065	COG1725	Transcriptional regulator
C5746_RS09070	COG3573	Dehydrogenase
C5746_RS09085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5746_RS09090	COG2149	membrane
C5746_RS09105	COG4948	Mandelate Racemase Muconate Lactonizing
C5746_RS09115	COG1960	acyl-CoA dehydrogenase activity
C5746_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS09140	COG3876	Protein conserved in bacteria
C5746_RS09150	COG0789	Transcriptional regulator
C5746_RS09170	COG1960	acyl-CoA dehydrogenase activity
C5746_RS09205	COG1132	(ABC) transporter
C5746_RS09215	COG2851	Citrate transporter
C5746_RS09220	COG1309	transcriptional regulator
C5746_RS09240	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C5746_RS09245	COG2188	Transcriptional regulator
C5746_RS09280	COG2755	lipolytic protein G-D-S-L family
C5746_RS09290	COG1725	Transcriptional regulator
C5746_RS09305	COG0326	Molecular chaperone. Has ATPase activity
C5746_RS09310	COG2226	methyltransferase
C5746_RS09330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5746_RS09385	COG0587	DNA-directed DNA polymerase activity
C5746_RS09425	COG2259	Doxx family
C5746_RS09480	COG0641	radical SAM
C5746_RS09515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS09525	COG1126	abc transporter atp-binding protein
C5746_RS09540	COG0765	amino acid transport
C5746_RS09555	COG1799	cell septum assembly
C5746_RS09560	COG1960	acyl-CoA dehydrogenase activity
C5746_RS09565	COG0477	Major facilitator Superfamily
C5746_RS09570	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS09590	COG0438	transferase activity, transferring glycosyl groups
C5746_RS09605	COG1160	GTP binding
C5746_RS09615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5746_RS09645	COG3541	Predicted nucleotidyltransferase
C5746_RS09655	COG0494	nUDIX hydrolase
C5746_RS09670	COG1187	pseudouridine synthase activity
C5746_RS09675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5746_RS09680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5746_RS09695	COG0686	Belongs to the AlaDH PNT family
C5746_RS09705	COG0494	nUDIX hydrolase
C5746_RS09710	COG0504	CTP synthase activity
C5746_RS09720	COG3387	PFAM Glycoside hydrolase 15-related
C5746_RS09725	COG2897	thiosulfate sulfurtransferase activity
C5746_RS09735	COG0297	glycogen (starch) synthase activity
C5746_RS09745	COG0497	DNA recombination
C5746_RS09750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5746_RS09770	COG1120	ATPase activity
C5746_RS09775	COG0647	UMP catabolic process
C5746_RS09810	COG2094	Belongs to the DNA glycosylase MPG family
C5746_RS09820	COG1881	PFAM PEBP family protein
C5746_RS09845	COG1119	ATPase activity
C5746_RS09860	COG2197	response regulator
C5746_RS09870	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS09880	COG0842	Transport permease protein
C5746_RS09880	COG1716	ATPase activity
C5746_RS09880	COG1131	(ABC) transporter
C5746_RS09885	COG3830	Belongs to the UPF0237 family
C5746_RS09885	COG0560	Phosphoserine phosphatase
C5746_RS09900	COG2807	transmembrane transport
C5746_RS09905	COG2186	Transcriptional regulator
C5746_RS09915	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5746_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS09925	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C5746_RS09960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5746_RS09980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5746_RS09985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS10000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5746_RS10045	COG4689	acetoacetate decarboxylase
C5746_RS10055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5746_RS10070	COG3387	PFAM Glycoside hydrolase 15-related
C5746_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS10100	COG1302	Protein conserved in bacteria
C5746_RS10110	COG1024	Enoyl-CoA hydratase
C5746_RS10120	COG0488	(ABC) transporter
C5746_RS10145	COG0235	Class ii aldolase
C5746_RS10160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C5746_RS10165	COG1492	cobalamin metabolic process
C5746_RS10180	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C5746_RS10185	COG1797	cobyrinic acid a,c-diamide synthase activity
C5746_RS10220	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C5746_RS10240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5746_RS10270	COG1902	pentaerythritol trinitrate reductase activity
C5746_RS10275	COG1846	Transcriptional regulator
C5746_RS10305	COG4166	transmembrane transport
C5746_RS10345	COG1414	Transcriptional regulator
C5746_RS10355	COG0768	penicillin binding
C5746_RS10375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5746_RS10380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5746_RS10435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5746_RS10440	COG2171	N-acyltransferase activity
C5746_RS10455	COG3226	Transcriptional regulator
C5746_RS10460	COG2076	Multidrug Resistance protein
C5746_RS10485	COG0822	iron-sulfur transferase activity
C5746_RS10490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5746_RS10495	COG0396	ATPase activity
C5746_RS10505	COG0719	Fe-S assembly protein
C5746_RS10520	COG1131	(ABC) transporter
C5746_RS10540	COG0109	protoheme IX farnesyltransferase activity
C5746_RS10550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5746_RS10565	COG0363	glucosamine-6-phosphate deaminase activity
C5746_RS10585	COG0166	Belongs to the GPI family
C5746_RS10595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5746_RS10600	COG0149	triose-phosphate isomerase activity
C5746_RS10605	COG0126	phosphoglycerate kinase activity
C5746_RS10610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5746_RS10615	COG1481	regulation of sporulation
C5746_RS10620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5746_RS10625	COG1660	Displays ATPase and GTPase activities
C5746_RS10630	COG0322	excinuclease ABC activity
C5746_RS10655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5746_RS10725	COG0556	nucleotide-excision repair
C5746_RS10735	COG0584	glycerophosphoryl diester phosphodiesterase
C5746_RS10740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5746_RS10745	COG0477	Major facilitator Superfamily
C5746_RS10755	COG2313	pseudouridylate synthase activity
C5746_RS10775	COG0436	Aminotransferase
C5746_RS10805	COG1309	transcriptional regulator
C5746_RS10820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5746_RS10825	COG0330	HflC and HflK could
C5746_RS10840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5746_RS10860	COG0237	dephospho-CoA kinase activity
C5746_RS10885	COG2226	methyltransferase
C5746_RS10890	COG1643	Atp-dependent helicase
C5746_RS10925	COG2050	protein possibly involved in aromatic compounds catabolism
C5746_RS10980	COG0737	Belongs to the 5'-nucleotidase family
C5746_RS11000	COG1846	Transcriptional regulator
C5746_RS11010	COG2267	carboxylic ester hydrolase activity
C5746_RS11020	COG1605	Chorismate mutase
C5746_RS11020	COG0287	Prephenate dehydrogenase
C5746_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS11050	COG1024	Enoyl-CoA hydratase
C5746_RS11075	COG1278	Cold shock
C5746_RS11080	COG0183	Belongs to the thiolase family
C5746_RS11085	COG1309	transcriptional regulator
C5746_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS11095	COG1024	Enoyl-CoA hydratase
C5746_RS11100	COG1960	acyl-CoA dehydrogenase activity
C5746_RS11105	COG1960	acyl-CoA dehydrogenase activity
C5746_RS11135	COG0070	glutamate synthase
C5746_RS11135	COG0067	glutamate synthase
C5746_RS11135	COG0069	glutamate synthase activity
C5746_RS11165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS11170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5746_RS11175	COG2301	Belongs to the HpcH HpaI aldolase family
C5746_RS11180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5746_RS11195	COG0159	tryptophan synthase activity
C5746_RS11200	COG0133	tryptophan synthase activity
C5746_RS11210	COG0134	indole-3-glycerol-phosphate synthase activity
C5746_RS11230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5746_RS11235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5746_RS11255	COG0107	imidazoleglycerol-phosphate synthase activity
C5746_RS11260	COG0251	oxidation-reduction process
C5746_RS11265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5746_RS11270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5746_RS11275	COG0131	Imidazoleglycerol-phosphate dehydratase
C5746_RS11280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5746_RS11285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5746_RS11305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5746_RS11325	COG1432	Conserved Protein
C5746_RS11335	COG0587	DNA-directed DNA polymerase activity
C5746_RS11395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5746_RS11410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5746_RS11425	COG1799	cell septum assembly
C5746_RS11430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5746_RS11450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5746_RS11455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5746_RS11465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5746_RS11470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5746_RS11480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5746_RS11485	COG0768	penicillin binding
C5746_RS11495	COG0275	rRNA processing
C5746_RS11505	COG0714	Associated with various cellular activities
C5746_RS11525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5746_RS11535	COG1121	(ABC) transporter
C5746_RS11555	COG1233	COG1233 Phytoene dehydrogenase and related
C5746_RS11570	COG0352	thiamine-phosphate diphosphorylase activity
C5746_RS11590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS11590	COG2022	thiamine diphosphate biosynthetic process
C5746_RS11600	COG2022	thiamine diphosphate biosynthetic process
C5746_RS11605	COG0515	serine threonine protein kinase
C5746_RS11605	COG2815	serine threonine protein kinase
C5746_RS11610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5746_RS11620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5746_RS11625	COG2193	ferroxidase activity
C5746_RS11635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C5746_RS11650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5746_RS11655	COG0205	6-phosphofructokinase activity
C5746_RS11665	COG4585	Histidine kinase
C5746_RS11695	COG1940	carbohydrate kinase activity
C5746_RS11705	COG0003	Pfam Anion-transporting ATPase
C5746_RS11720	COG1022	Amp-dependent synthetase and ligase
C5746_RS11770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5746_RS11775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5746_RS11780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5746_RS11785	COG0723	plastoquinol--plastocyanin reductase activity
C5746_RS11795	COG1845	cytochrome c oxidase, subunit III
C5746_RS11805	COG1376	ErfK ybiS ycfS ynhG family protein
C5746_RS11815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5746_RS11820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5746_RS11830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS11855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5746_RS11870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5746_RS11875	COG2197	response regulator
C5746_RS11900	COG4106	trans-aconitate 2-methyltransferase activity
C5746_RS11905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5746_RS11925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5746_RS11930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5746_RS11930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5746_RS11945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C5746_RS11955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5746_RS11960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5746_RS11975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5746_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS12005	COG1090	epimerase
C5746_RS12030	COG0321	lipoyl(octanoyl) transferase activity
C5746_RS12035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5746_RS12150	COG0745	RESPONSE REGULATOR receiver
C5746_RS12155	COG2409	Drug exporters of the RND superfamily
C5746_RS12165	COG2197	response regulator
C5746_RS12225	COG0366	Alpha amylase catalytic
C5746_RS12230	COG3833	ABC-type maltose transport systems, permease component
C5746_RS12240	COG2182	Extracellular solute-binding protein
C5746_RS12245	COG1609	Transcriptional regulator
C5746_RS12255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5746_RS12270	COG2890	protein-(glutamine-N5) methyltransferase activity
C5746_RS12280	COG1309	transcriptional regulator
C5746_RS12310	COG0326	Molecular chaperone. Has ATPase activity
C5746_RS12320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5746_RS12325	COG0174	glutamine synthetase
C5746_RS12345	COG2132	Multicopper oxidase
C5746_RS12350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5746_RS12350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5746_RS12365	COG1309	transcriptional regulator
C5746_RS12375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5746_RS12395	COG1994	Peptidase M50
C5746_RS12425	COG5398	heme oxygenase
C5746_RS12455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5746_RS12460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS12465	COG1120	ATPase activity
C5746_RS12475	COG2837	iron assimilation
C5746_RS12480	COG0672	)-iron permease
C5746_RS12500	COG1834	amidinotransferase
C5746_RS12515	COG2814	Major facilitator Superfamily
C5746_RS12525	COG3540	Alkaline phosphatase
C5746_RS12540	COG0384	phenazine biosynthesis protein PhzF
C5746_RS12570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5746_RS12610	COG3022	response to hydroperoxide
C5746_RS12615	COG0800	Aldolase
C5746_RS12630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5746_RS12635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5746_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS12655	COG2030	dehydratase
C5746_RS12660	COG1131	(ABC) transporter
C5746_RS12665	COG0842	Transport permease protein
C5746_RS12670	COG4585	Histidine kinase
C5746_RS12675	COG2197	response regulator
C5746_RS12705	COG0183	Belongs to the thiolase family
C5746_RS12710	COG1960	acyl-CoA dehydrogenase activity
C5746_RS12715	COG3340	Belongs to the peptidase S51 family
C5746_RS12730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5746_RS12735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5746_RS12750	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5746_RS12760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS12770	COG1796	DNA polymerase
C5746_RS12770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5746_RS12800	COG0438	transferase activity, transferring glycosyl groups
C5746_RS12805	COG1309	transcriptional regulator
C5746_RS12830	COG0559	Belongs to the binding-protein-dependent transport system permease family
C5746_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS12875	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS12940	COG3845	ABC transporter
C5746_RS12960	COG0183	Belongs to the thiolase family
C5746_RS12965	COG2124	cytochrome p450
C5746_RS13020	COG0390	transport system, permease component
C5746_RS13040	COG2259	Doxx family
C5746_RS13080	COG4585	Histidine kinase
C5746_RS13085	COG2197	response regulator
C5746_RS13090	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS13105	COG0657	acetylesterase activity
C5746_RS13185	COG1358	cellular component organization or biogenesis
C5746_RS13230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5746_RS13240	COG0477	Major facilitator Superfamily
C5746_RS13265	COG0667	Aldo Keto reductase
C5746_RS13270	COG0789	Transcriptional regulator
C5746_RS13345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5746_RS13350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5746_RS13355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS13380	COG1309	transcriptional regulator
C5746_RS13385	COG1231	oxidoreductase activity
C5746_RS13390	COG1280	lysine exporter protein (LysE YggA)
C5746_RS13400	COG1764	response to oxidative stress
C5746_RS13405	COG2130	NADP-dependent
C5746_RS13425	COG1077	Cell shape determining protein MreB Mrl
C5746_RS13435	COG1522	sequence-specific DNA binding
C5746_RS13445	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS13450	COG0825	malonyl-CoA metabolic process
C5746_RS13450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5746_RS13460	COG1132	(ABC) transporter
C5746_RS13490	COG1070	Carbohydrate kinase
C5746_RS13505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5746_RS13510	COG0358	DNA primase activity
C5746_RS13520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5746_RS13535	COG0561	phosphatase activity
C5746_RS13550	COG2949	membrane
C5746_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS13610	COG0574	Belongs to the PEP-utilizing enzyme family
C5746_RS13610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5746_RS13650	COG0423	glycine-tRNA ligase activity
C5746_RS13655	COG3443	Belongs to the bacterial solute-binding protein 9 family
C5746_RS13655	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5746_RS13660	COG1121	(ABC) transporter
C5746_RS13665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5746_RS13675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5746_RS13680	COG1381	Involved in DNA repair and RecF pathway recombination
C5746_RS13700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5746_RS13715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5746_RS13735	COG2315	Protein conserved in bacteria
C5746_RS13745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5746_RS13755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5746_RS13755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5746_RS13765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5746_RS13770	COG1234	tRNA 3'-trailer cleavage
C5746_RS13775	COG0537	adenosine 5'-monophosphoramidase activity
C5746_RS13780	COG4946	Tricorn protease homolog
C5746_RS13780	COG0793	Belongs to the peptidase S41A family
C5746_RS13800	COG0484	heat shock protein binding
C5746_RS13805	COG1420	regulation of RNA biosynthetic process
C5746_RS13835	COG0481	GTPase activity
C5746_RS13840	COG0268	Binds directly to 16S ribosomal RNA
C5746_RS13850	COG0667	Aldo Keto reductase
C5746_RS13870	COG1555	photosystem II stabilization
C5746_RS13875	COG1307	EDD domain protein, DegV family
C5746_RS13885	COG0495	leucyl-tRNA aminoacylation
C5746_RS13930	COG0588	phosphoglycerate mutase activity
C5746_RS13935	COG0799	negative regulation of ribosome biogenesis
C5746_RS13945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5746_RS13950	COG0501	Belongs to the peptidase M48B family
C5746_RS13965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5746_RS13975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5746_RS14025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5746_RS14030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5746_RS14035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5746_RS14040	COG4941	Belongs to the sigma-70 factor family
C5746_RS14045	COG3795	YCII-related domain
C5746_RS14050	COG1530	ribonuclease E activity
C5746_RS14075	COG0772	Belongs to the SEDS family
C5746_RS14095	COG1077	Cell shape determining protein MreB Mrl
C5746_RS14100	COG0105	UTP biosynthetic process
C5746_RS14110	COG0285	dihydrofolate synthase activity
C5746_RS14115	COG0525	valine-tRNA ligase activity
C5746_RS14135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5746_RS14140	COG0740	serine-type endopeptidase activity
C5746_RS14145	COG0740	serine-type endopeptidase activity
C5746_RS14150	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5746_RS14170	COG3594	Acyltransferase
C5746_RS14185	COG1136	(ABC) transporter
C5746_RS14185	COG0577	efflux transmembrane transporter activity
C5746_RS14190	COG0475	glutathione-regulated potassium exporter activity
C5746_RS14200	COG4552	Acetyltransferase involved in intracellular survival and related
C5746_RS14215	COG1113	amino acid transport
C5746_RS14230	COG1113	amino acid transport
C5746_RS14235	COG0588	phosphoglycerate mutase activity
C5746_RS14245	COG1653	transport
C5746_RS14250	COG1175	transmembrane transport
C5746_RS14255	COG0395	ABC-type sugar transport system, permease component
C5746_RS14265	COG1349	DNA-binding transcription factor activity
C5746_RS14270	COG3842	ATPase activity
C5746_RS14275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5746_RS14295	COG1132	(ABC) transporter
C5746_RS14305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5746_RS14325	COG0110	maltose O-acetyltransferase activity
C5746_RS14360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5746_RS14385	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5746_RS14405	COG4266	Belongs to the allantoicase family
C5746_RS14440	COG0668	transmembrane transport
C5746_RS14455	COG1175	transmembrane transport
C5746_RS14460	COG0395	ABC-type sugar transport system, permease component
C5746_RS14465	COG1486	melibiose metabolic process
C5746_RS14480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS14510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5746_RS14530	COG0577	efflux transmembrane transporter activity
C5746_RS14530	COG1136	(ABC) transporter
C5746_RS14565	COG0629	single-stranded DNA binding
C5746_RS14670	COG3629	intracellular signal transduction
C5746_RS14680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS14685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5746_RS14735	COG0477	Major facilitator Superfamily
C5746_RS14745	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS14750	COG3321	synthase
C5746_RS14750	COG0604	alcohol dehydrogenase
C5746_RS14765	COG3962	Belongs to the TPP enzyme family
C5746_RS14770	COG3718	enzyme involved in inositol metabolism
C5746_RS14780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS14815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5746_RS14825	COG2318	DinB family
C5746_RS14895	COG0673	inositol 2-dehydrogenase activity
C5746_RS14900	COG1609	Transcriptional regulator
C5746_RS14920	COG1472	Belongs to the glycosyl hydrolase 3 family
C5746_RS14955	COG0028	Belongs to the TPP enzyme family
C5746_RS14965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS14980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5746_RS15010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5746_RS15035	COG1946	Acyl-CoA thioesterase
C5746_RS15050	COG0463	Glycosyl transferase, family 2
C5746_RS15055	COG1309	transcriptional regulator
C5746_RS15060	COG2311	Membrane
C5746_RS15065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5746_RS15075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5746_RS15080	COG1960	acyl-CoA dehydrogenase activity
C5746_RS15105	COG0076	glutamate decarboxylase activity
C5746_RS15110	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C5746_RS15140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS15150	COG0589	response to stress
C5746_RS15155	COG4977	sequence-specific DNA binding
C5746_RS15180	COG0395	ABC-type sugar transport system, permease component
C5746_RS15205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5746_RS15220	COG0406	alpha-ribazole phosphatase activity
C5746_RS15270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS15285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS15290	COG0765	amino acid transport
C5746_RS15295	COG0765	amino acid transport
C5746_RS15300	COG1126	abc transporter atp-binding protein
C5746_RS15320	COG0745	RESPONSE REGULATOR receiver
C5746_RS15325	COG2205	protein histidine kinase activity
C5746_RS15335	COG0477	Major facilitator Superfamily
C5746_RS15340	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS15345	COG3397	chitin binding
C5746_RS15435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS15440	COG2188	Transcriptional regulator
C5746_RS15450	COG1940	carbohydrate kinase activity
C5746_RS15455	COG0673	inositol 2-dehydrogenase activity
C5746_RS15460	COG4702	Belongs to the UPF0303 family
C5746_RS15485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS15495	COG3764	Sortase (surface protein transpeptidase)
C5746_RS15520	COG1404	Belongs to the peptidase S8 family
C5746_RS15600	COG0667	Aldo Keto reductase
C5746_RS15605	COG4249	Peptidase C14 caspase catalytic subunit p20
C5746_RS15605	COG2319	Wd-40 repeat
C5746_RS15630	COG0640	Transcriptional regulator
C5746_RS15645	COG2318	DinB family
C5746_RS15660	COG3896	Chloramphenicol phosphotransferase-like protein
C5746_RS15715	COG2733	membrane
C5746_RS15745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS15785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5746_RS15795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5746_RS15800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5746_RS15805	COG1263	PTS System
C5746_RS15810	COG1263	PTS System
C5746_RS15815	COG1234	tRNA 3'-trailer cleavage
C5746_RS15845	COG1113	amino acid transport
C5746_RS15855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5746_RS15865	COG1335	isochorismatase
C5746_RS15900	COG0277	FAD linked oxidase domain protein
C5746_RS15910	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5746_RS15920	COG1174	glycine betaine transport
C5746_RS15930	COG1174	glycine betaine transport
C5746_RS15985	COG3654	unkown
C5746_RS16030	COG0789	Transcriptional regulator
C5746_RS16130	COG1404	Belongs to the peptidase S8 family
C5746_RS16160	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5746_RS16170	COG1678	Uncharacterized ACR, COG1678
C5746_RS16175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5746_RS16180	COG0776	regulation of translation
C5746_RS16190	COG3973	AAA domain
C5746_RS16245	COG0583	DNA-binding transcription factor activity
C5746_RS16260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5746_RS16265	COG0793	Belongs to the peptidase S41A family
C5746_RS16270	COG2177	Part of the ABC transporter FtsEX involved in
C5746_RS16275	COG2884	Cell division ATP-binding protein ftsE
C5746_RS16290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5746_RS16295	COG0515	serine threonine protein kinase
C5746_RS16300	COG0515	serine threonine protein kinase
C5746_RS16305	COG1674	ftsk spoiiie
C5746_RS16310	COG1653	transport
C5746_RS16315	COG1175	transmembrane transport
C5746_RS16320	COG0395	ABC-type sugar transport system, permease component
C5746_RS16325	COG1216	Glycosyl transferase, family 2
C5746_RS16325	COG1442	glycosyl transferase family 8
C5746_RS16330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5746_RS16350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5746_RS16355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5746_RS16355	COG0463	Glycosyl transferase, family 2
C5746_RS16360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5746_RS16365	COG1309	transcriptional regulator
C5746_RS16375	COG1134	teichoic acid transport
C5746_RS16375	COG1388	LysM domain
C5746_RS16390	COG2902	Dehydrogenase
C5746_RS16415	COG0653	protein targeting
C5746_RS16430	COG2197	response regulator
C5746_RS16435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5746_RS16445	COG0823	Involved in the tonB-independent uptake of proteins
C5746_RS16450	COG5002	protein histidine kinase activity
C5746_RS16455	COG0745	RESPONSE REGULATOR receiver
C5746_RS16460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5746_RS16480	COG0714	Associated with various cellular activities
C5746_RS16525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5746_RS16535	COG1482	cell wall glycoprotein biosynthetic process
C5746_RS16545	COG2835	tetraacyldisaccharide 4'-kinase activity
C5746_RS16550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5746_RS16595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5746_RS16600	COG0778	Nitroreductase
C5746_RS16600	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C5746_RS16630	COG1316	TRANSCRIPTIONal
C5746_RS16635	COG1316	TRANSCRIPTIONal
C5746_RS16650	COG1607	acyl-coa hydrolase
C5746_RS16655	COG1316	TRANSCRIPTIONal
C5746_RS16660	COG2226	methyltransferase
C5746_RS16710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5746_RS16745	COG2205	protein histidine kinase activity
C5746_RS16750	COG0745	RESPONSE REGULATOR receiver
C5746_RS16755	COG3104	oligopeptide transport
C5746_RS16785	COG1366	Belongs to the anti-sigma-factor antagonist family
C5746_RS16790	COG1191	sigma factor activity
C5746_RS16795	COG1228	amidohydrolase
C5746_RS16810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5746_RS16855	COG1595	DNA-templated transcription, initiation
C5746_RS16865	COG4221	oxidoreductase activity
C5746_RS16885	COG0183	Belongs to the thiolase family
C5746_RS16915	COG1136	(ABC) transporter
C5746_RS16920	COG0577	efflux transmembrane transporter activity
C5746_RS16920	COG1136	(ABC) transporter
C5746_RS16925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5746_RS16930	COG1252	NADH dehydrogenase
C5746_RS16950	COG0148	phosphopyruvate hydratase activity
C5746_RS16985	COG0463	Glycosyl transferase, family 2
C5746_RS17075	COG0577	efflux transmembrane transporter activity
C5746_RS17080	COG1136	(ABC) transporter
C5746_RS17085	COG2814	Major facilitator Superfamily
C5746_RS17095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS17125	COG4585	Histidine kinase
C5746_RS17140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5746_RS17145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5746_RS17150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5746_RS17155	COG0193	aminoacyl-tRNA hydrolase activity
C5746_RS17165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5746_RS17175	COG1309	transcriptional regulator
C5746_RS17195	COG4106	trans-aconitate 2-methyltransferase activity
C5746_RS17220	COG2197	response regulator
C5746_RS17230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5746_RS17275	COG0488	(ABC) transporter
C5746_RS17285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5746_RS17290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5746_RS17300	COG0084	hydrolase, TatD family'
C5746_RS17350	COG0442	prolyl-tRNA aminoacylation
C5746_RS17405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5746_RS17410	COG1122	ATPase activity
C5746_RS17420	COG0310	cobalt ion transport
C5746_RS17430	COG2409	Drug exporters of the RND superfamily
C5746_RS17440	COG0793	Belongs to the peptidase S41A family
C5746_RS17440	COG4946	Tricorn protease homolog
C5746_RS17450	COG1595	DNA-templated transcription, initiation
C5746_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS17495	COG2267	carboxylic ester hydrolase activity
C5746_RS17500	COG2072	flavoprotein involved in K transport
C5746_RS17505	COG0789	Transcriptional regulator
C5746_RS17555	COG0315	cyclic pyranopterin monophosphate synthase activity
C5746_RS17555	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5746_RS17560	COG0315	cyclic pyranopterin monophosphate synthase activity
C5746_RS17570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5746_RS17575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5746_RS17580	COG2366	antibiotic biosynthetic process
C5746_RS17585	COG3263	regulation of cellular component size
C5746_RS17600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5746_RS17610	COG1970	mechanosensitive ion channel activity
C5746_RS17630	COG0437	4 iron, 4 sulfur cluster binding
C5746_RS17635	COG0243	molybdopterin cofactor binding
C5746_RS17645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5746_RS17660	COG3191	aminopeptidase activity
C5746_RS17670	COG0477	Major facilitator Superfamily
C5746_RS17685	COG1247	-acetyltransferase
C5746_RS17695	COG3384	dioxygenase
C5746_RS17700	COG1846	Transcriptional regulator
C5746_RS17735	COG0582	viral genome integration into host DNA
C5746_RS17780	COG2188	Transcriptional regulator
C5746_RS17830	COG1017	nitric oxide dioxygenase activity
C5746_RS17830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5746_RS17870	COG1686	Belongs to the peptidase S11 family
C5746_RS17945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5746_RS17975	COG2226	methyltransferase
C5746_RS17985	COG0789	Transcriptional regulator
C5746_RS17990	COG1902	pentaerythritol trinitrate reductase activity
C5746_RS18015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5746_RS18070	COG2375	cellular response to nickel ion
C5746_RS18070	COG1132	(ABC) transporter
C5746_RS18100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS18110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5746_RS18125	COG1196	nuclear chromosome segregation
C5746_RS18125	COG0741	lytic transglycosylase activity
C5746_RS18125	COG0739	heme binding
C5746_RS18140	COG0463	Glycosyl transferase, family 2
C5746_RS18140	COG0457	Tetratricopeptide repeat
C5746_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS18160	COG1309	transcriptional regulator
C5746_RS18175	COG1301	dicarboxylic acid transport
C5746_RS18190	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5746_RS18200	COG0163	prenyltransferase activity
C5746_RS18205	COG0705	Rhomboid family
C5746_RS18210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5746_RS18215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5746_RS18220	COG0829	nickel cation binding
C5746_RS18225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5746_RS18230	COG0830	nickel cation binding
C5746_RS18235	COG0804	urea catabolic process
C5746_RS18240	COG0832	Belongs to the urease beta subunit family
C5746_RS18240	COG0831	urea catabolic process
C5746_RS18275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5746_RS18280	COG1333	cytochrome c biogenesis protein
C5746_RS18300	COG0406	alpha-ribazole phosphatase activity
C5746_RS18305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5746_RS18425	COG1846	Transcriptional regulator
C5746_RS18435	COG1742	UPF0060 membrane protein
C5746_RS18445	COG1690	Belongs to the RtcB family
C5746_RS18465	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5746_RS18470	COG0018	arginyl-trna synthetase
C5746_RS18495	COG1309	transcriptional regulator
C5746_RS18540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS18545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5746_RS18550	COG0113	porphobilinogen synthase activity
C5746_RS18555	COG1648	precorrin-2 dehydrogenase activity
C5746_RS18555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5746_RS18560	COG0181	hydroxymethylbilane synthase activity
C5746_RS18565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5746_RS18570	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5746_RS18625	COG2223	nitrite transmembrane transporter activity
C5746_RS18665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5746_RS18675	COG1129	ABC transporter
C5746_RS18675	COG0842	Transport permease protein
C5746_RS18680	COG2226	methyltransferase
C5746_RS18690	COG4991	sh3 domain protein
C5746_RS18695	COG0515	serine threonine protein kinase
C5746_RS18695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5746_RS18700	COG0129	dihydroxy-acid dehydratase activity
C5746_RS18710	COG1082	Xylose isomerase domain protein TIM barrel
C5746_RS18715	COG0248	Ppx GppA phosphatase
C5746_RS18735	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C5746_RS18745	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS18750	COG1194	a g-specific adenine glycosylase
C5746_RS18755	COG1595	DNA-templated transcription, initiation
C5746_RS18765	COG0745	RESPONSE REGULATOR receiver
C5746_RS18770	COG2205	protein histidine kinase activity
C5746_RS18775	COG0477	Major facilitator Superfamily
C5746_RS18785	COG0739	heme binding
C5746_RS18810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5746_RS18825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5746_RS18835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5746_RS18840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5746_RS18865	COG1660	Displays ATPase and GTPase activities
C5746_RS18870	COG2197	response regulator
C5746_RS18885	COG0649	NAD binding
C5746_RS18900	COG1174	glycine betaine transport
C5746_RS18905	COG1174	glycine betaine transport
C5746_RS18910	COG1125	glycine betaine transport
C5746_RS18910	COG0517	IMP dehydrogenase activity
C5746_RS18920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5746_RS18920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5746_RS18925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5746_RS18935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5746_RS18950	COG0302	gtp cyclohydrolase
C5746_RS18965	COG0037	tRNA processing
C5746_RS18975	COG2027	D-alanyl-D-alanine carboxypeptidase
C5746_RS18980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5746_RS18995	COG0393	Putative heavy-metal-binding
C5746_RS19000	COG0789	Transcriptional regulator
C5746_RS19010	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5746_RS19015	COG0076	glutamate decarboxylase activity
C5746_RS19035	COG2318	DinB family
C5746_RS19040	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS19075	COG0577	efflux transmembrane transporter activity
C5746_RS19075	COG1136	(ABC) transporter
C5746_RS19095	COG3424	synthase
C5746_RS19140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5746_RS19145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5746_RS19150	COG1754	DNA topoisomerase type I activity
C5746_RS19150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5746_RS19160	COG2890	protein-(glutamine-N5) methyltransferase activity
C5746_RS19170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C5746_RS19180	COG1366	Belongs to the anti-sigma-factor antagonist family
C5746_RS19185	COG1111	helicase
C5746_RS19185	COG1205	dead DEAH box helicase
C5746_RS19245	COG0288	reversible hydration of carbon dioxide
C5746_RS19250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5746_RS19255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5746_RS19265	COG2267	carboxylic ester hydrolase activity
C5746_RS19320	COG0003	Pfam Anion-transporting ATPase
C5746_RS19335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS19340	COG1610	YqeY-like protein
C5746_RS19345	COG1408	metallophosphoesterase
C5746_RS19360	COG0477	Major facilitator Superfamily
C5746_RS19400	COG0577	efflux transmembrane transporter activity
C5746_RS19400	COG1136	(ABC) transporter
C5746_RS19405	COG0577	efflux transmembrane transporter activity
C5746_RS19410	COG2205	protein histidine kinase activity
C5746_RS19415	COG0745	RESPONSE REGULATOR receiver
C5746_RS19420	COG2755	lipolytic protein G-D-S-L family
C5746_RS19455	COG1595	DNA-templated transcription, initiation
C5746_RS19460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5746_RS19475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5746_RS19480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5746_RS19495	COG1802	Transcriptional regulator
C5746_RS19500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5746_RS19505	COG0693	protein deglycase activity
C5746_RS19550	COG0592	DNA-directed DNA polymerase activity
C5746_RS19570	COG0702	epimerase
C5746_RS19580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5746_RS19595	COG1131	(ABC) transporter
C5746_RS19600	COG3559	Exporter of polyketide antibiotics
C5746_RS19610	COG2124	cytochrome p450
C5746_RS19615	COG2197	response regulator
C5746_RS19620	COG4585	Histidine kinase
C5746_RS19630	COG3844	kynureninase activity
C5746_RS19645	COG0477	Major facilitator Superfamily
C5746_RS19650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5746_RS19655	COG0191	fructose-bisphosphate aldolase activity
C5746_RS19660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5746_RS19675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5746_RS19700	COG0542	response to heat
C5746_RS19730	COG0789	Transcriptional regulator
C5746_RS19735	COG0484	heat shock protein binding
C5746_RS19740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5746_RS19745	COG0443	Heat shock 70 kDa protein
C5746_RS19750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5746_RS19755	COG2181	nitrate reductase activity
C5746_RS19755	COG0247	lactate metabolic process
C5746_RS19775	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C5746_RS19780	COG0717	Belongs to the dCTP deaminase family
C5746_RS19870	COG0681	Belongs to the peptidase S26 family
C5746_RS19880	COG3226	Transcriptional regulator
C5746_RS19925	COG2124	cytochrome p450
C5746_RS19930	COG2124	cytochrome p450
C5746_RS19950	COG2340	Cysteine-rich secretory protein family
C5746_RS19955	COG2340	Cysteine-rich secretory protein family
C5746_RS19965	COG2197	response regulator
C5746_RS19975	COG1131	(ABC) transporter
C5746_RS19990	COG1011	Hydrolase
C5746_RS20005	COG1216	Glycosyl transferase, family 2
C5746_RS20010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5746_RS20015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5746_RS20020	COG1993	acr, cog1993
C5746_RS20025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5746_RS20030	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS20040	COG0513	Belongs to the DEAD box helicase family
C5746_RS20045	COG1278	Cold shock
C5746_RS20125	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5746_RS20130	COG2268	Band 7 protein
C5746_RS20140	COG0490	domain, Protein
C5746_RS20145	COG0475	glutathione-regulated potassium exporter activity
C5746_RS20205	COG0180	Tryptophanyl-tRNA synthetase
C5746_RS20235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS20280	COG2205	protein histidine kinase activity
C5746_RS20285	COG0745	RESPONSE REGULATOR receiver
C5746_RS20290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5746_RS20310	COG0778	Nitroreductase
C5746_RS20345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5746_RS20360	COG1741	Belongs to the pirin family
C5746_RS20370	COG1960	acyl-CoA dehydrogenase activity
C5746_RS20380	COG1362	aminopeptidase activity
C5746_RS20390	COG3903	Transcriptional regulator
C5746_RS20390	COG3629	intracellular signal transduction
C5746_RS20465	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5746_RS20470	COG0022	dehydrogenase e1 component
C5746_RS20495	COG0515	serine threonine protein kinase
C5746_RS20500	COG0515	serine threonine protein kinase
C5746_RS20520	COG1136	(ABC) transporter
C5746_RS20520	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5746_RS20535	COG0604	alcohol dehydrogenase
C5746_RS20535	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS20535	COG3321	synthase
C5746_RS20570	COG1522	sequence-specific DNA binding
C5746_RS20580	COG1309	transcriptional regulator
C5746_RS20605	COG3396	Phenylacetate-CoA oxygenase
C5746_RS20610	COG3460	Phenylacetate-CoA oxygenase
C5746_RS20615	COG3396	Phenylacetate-CoA oxygenase
C5746_RS20620	COG2151	metal-sulfur cluster biosynthetic enzyme
C5746_RS20625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5746_RS20635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5746_RS20660	COG1733	regulation of RNA biosynthetic process
C5746_RS20665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5746_RS20675	COG1716	ATPase activity
C5746_RS20680	COG1716	ATPase activity
C5746_RS20695	COG0768	penicillin binding
C5746_RS20700	COG0515	serine threonine protein kinase
C5746_RS20705	COG3764	Sortase (surface protein transpeptidase)
C5746_RS20710	COG3764	Sortase (surface protein transpeptidase)
C5746_RS20725	COG3764	Sortase (surface protein transpeptidase)
C5746_RS20740	COG0705	Rhomboid family
C5746_RS20765	COG0515	serine threonine protein kinase
C5746_RS20805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5746_RS20815	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5746_RS20820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5746_RS20825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5746_RS20830	COG0592	DNA-directed DNA polymerase activity
C5746_RS20845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5746_RS20850	COG0594	ribonuclease P activity
C5746_RS20855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5746_RS20860	COG0706	membrane insertase activity
C5746_RS20870	COG0357	Ribosomal RNA small subunit methyltransferase G
C5746_RS20875	COG1192	Involved in chromosome partitioning
C5746_RS20890	COG3118	belongs to the thioredoxin family
C5746_RS20895	COG0492	ferredoxin-NADP+ reductase activity
C5746_RS20905	COG1595	DNA-templated transcription, initiation
C5746_RS20910	COG2815	serine threonine protein kinase
C5746_RS20910	COG0515	serine threonine protein kinase
C5746_RS20925	COG0617	tRNA 3'-terminal CCA addition
C5746_RS20945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS20970	COG0360	Binds together with S18 to 16S ribosomal RNA
C5746_RS20975	COG0629	single-stranded DNA binding
C5746_RS20980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5746_RS20985	COG0359	binds to the 23S rRNA
C5746_RS20995	COG0305	Participates in initiation and elongation during chromosome replication
C5746_RS21055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5746_RS21130	COG0626	cystathionine gamma-synthase activity
C5746_RS21135	COG1950	PFAM Membrane protein of
C5746_RS21140	COG0662	Cupin 2, conserved barrel domain protein
C5746_RS21165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5746_RS21180	COG1609	Transcriptional regulator
C5746_RS21185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5746_RS21190	COG1271	oxidase subunit
C5746_RS21195	COG1294	oxidase, subunit
C5746_RS21200	COG4988	ABC transporter
C5746_RS21210	COG0561	phosphatase activity
C5746_RS21220	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C5746_RS21225	COG0789	Transcriptional regulator
C5746_RS21240	COG1131	(ABC) transporter
C5746_RS21270	COG0561	phosphatase activity
C5746_RS21275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5746_RS21280	COG0077	Prephenate dehydratase
C5746_RS21285	COG2837	iron assimilation
C5746_RS21290	COG2372	response to copper ion
C5746_RS21300	COG1999	signal sequence binding
C5746_RS21320	COG0006	proline dipeptidase activity
C5746_RS21335	COG0653	protein targeting
C5746_RS21350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5746_RS21390	COG1960	acyl-CoA dehydrogenase activity
C5746_RS21415	COG1595	DNA-templated transcription, initiation
C5746_RS21420	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS21455	COG0745	RESPONSE REGULATOR receiver
C5746_RS21460	COG2205	protein histidine kinase activity
C5746_RS21470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5746_RS21480	COG0477	Major facilitator Superfamily
C5746_RS21490	COG3467	pyridoxamine 5'-phosphate
C5746_RS21495	COG2353	YceI-like domain
C5746_RS21520	COG1191	sigma factor activity
C5746_RS21525	COG1191	sigma factor activity
C5746_RS21555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5746_RS21605	COG0464	growth
C5746_RS21615	COG2124	cytochrome p450
C5746_RS21700	COG0019	diaminopimelate decarboxylase activity
C5746_RS21715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5746_RS21740	COG0583	DNA-binding transcription factor activity
C5746_RS21750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5746_RS21775	COG0151	Belongs to the GarS family
C5746_RS21790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5746_RS21800	COG2197	response regulator
C5746_RS21835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5746_RS21840	COG0047	phosphoribosylformylglycinamidine synthase activity
C5746_RS21845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5746_RS21875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5746_RS21910	COG1643	Atp-dependent helicase
C5746_RS21920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5746_RS21920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5746_RS21925	COG0785	Cytochrome C biogenesis protein
C5746_RS21955	COG0513	Belongs to the DEAD box helicase family
C5746_RS22010	COG2268	Band 7 protein
C5746_RS22025	COG1196	nuclear chromosome segregation
C5746_RS22025	COG0741	lytic transglycosylase activity
C5746_RS22025	COG0739	heme binding
C5746_RS22030	COG0667	Aldo Keto reductase
C5746_RS22045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5746_RS22050	COG0579	oxidoreductase
C5746_RS22080	COG1252	NADH dehydrogenase
C5746_RS22120	COG2197	response regulator
C5746_RS22125	COG4585	Histidine kinase
C5746_RS22135	COG1131	(ABC) transporter
C5746_RS22180	COG0515	serine threonine protein kinase
C5746_RS22180	COG2815	serine threonine protein kinase
C5746_RS22185	COG2815	serine threonine protein kinase
C5746_RS22185	COG0515	serine threonine protein kinase
C5746_RS22190	COG1595	DNA-templated transcription, initiation
C5746_RS22200	COG0577	efflux transmembrane transporter activity
C5746_RS22290	COG0791	NLP P60 protein
C5746_RS22295	COG0671	phosphoesterase, PA-phosphatase related
C5746_RS22300	COG0277	FAD linked oxidase domain protein
C5746_RS22320	COG1937	Protein conserved in bacteria
C5746_RS22330	COG0306	phosphate transporter
C5746_RS22375	COG1116	anion transmembrane transporter activity
C5746_RS22380	COG1725	Transcriptional regulator
C5746_RS22385	COG0456	acetyltransferase
C5746_RS22390	COG0537	adenosine 5'-monophosphoramidase activity
C5746_RS22425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5746_RS22430	COG1609	Transcriptional regulator
C5746_RS22435	COG0745	RESPONSE REGULATOR receiver
C5746_RS22460	COG2897	thiosulfate sulfurtransferase activity
C5746_RS22500	COG3485	protocatechuate 3,4-dioxygenase
C5746_RS22515	COG1490	D-aminoacyl-tRNA deacylase activity
C5746_RS22530	COG4552	Acetyltransferase involved in intracellular survival and related
C5746_RS22555	COG0667	Aldo Keto reductase
C5746_RS22560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5746_RS22580	COG4977	sequence-specific DNA binding
C5746_RS22605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5746_RS22640	COG0438	transferase activity, transferring glycosyl groups
C5746_RS22685	COG0588	phosphoglycerate mutase activity
C5746_RS22700	COG5002	protein histidine kinase activity
C5746_RS22720	COG1329	Transcriptional regulator
C5746_RS22725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5746_RS22730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5746_RS22740	COG0215	cysteine-tRNA ligase activity
C5746_RS22760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5746_RS22770	COG3842	ATPase activity
C5746_RS22795	COG0477	Major facilitator Superfamily
C5746_RS22800	COG2816	NAD+ diphosphatase activity
C5746_RS22805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS22845	COG2197	response regulator
C5746_RS22880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5746_RS22910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5746_RS22920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS22925	COG2182	Extracellular solute-binding protein
C5746_RS22940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5746_RS22940	COG0561	phosphatase activity
C5746_RS22960	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C5746_RS22965	COG0463	Glycosyl transferase, family 2
C5746_RS23075	COG2205	protein histidine kinase activity
C5746_RS23080	COG0745	RESPONSE REGULATOR receiver
C5746_RS23100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5746_RS23105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5746_RS23155	COG3973	AAA domain
C5746_RS23165	COG1061	Type III restriction enzyme res subunit
C5746_RS23185	COG1120	ATPase activity
C5746_RS23190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS23195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS23260	COG1278	Cold shock
C5746_RS23265	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C5746_RS23270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5746_RS23280	COG2814	Major facilitator Superfamily
C5746_RS23310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5746_RS23320	COG2252	PERMEase
C5746_RS23330	COG1846	Transcriptional regulator
C5746_RS23350	COG0596	Alpha beta hydrolase
C5746_RS23360	COG0667	Aldo Keto reductase
C5746_RS23370	COG2267	carboxylic ester hydrolase activity
C5746_RS23390	COG0842	Transport permease protein
C5746_RS23405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5746_RS23490	COG1396	sequence-specific DNA binding
C5746_RS23530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5746_RS23560	COG0642	Histidine kinase
C5746_RS23565	COG0277	FAD linked oxidase domain protein
C5746_RS23565	COG0247	lactate metabolic process
C5746_RS23595	COG2264	protein methyltransferase activity
C5746_RS23625	COG1695	Transcriptional regulator
C5746_RS23645	COG5006	permease, DMT superfamily
C5746_RS23675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5746_RS23690	COG1024	Enoyl-CoA hydratase
C5746_RS23690	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS23710	COG0259	pyridoxamine-phosphate oxidase activity
C5746_RS23725	COG0577	efflux transmembrane transporter activity
C5746_RS23725	COG1136	(ABC) transporter
C5746_RS23745	COG0745	RESPONSE REGULATOR receiver
C5746_RS23750	COG2205	protein histidine kinase activity
C5746_RS23755	COG4821	SIS domain
C5746_RS23765	COG0596	Alpha beta hydrolase
C5746_RS23775	COG1131	(ABC) transporter
C5746_RS23845	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS23855	COG1960	acyl-CoA dehydrogenase activity
C5746_RS23860	COG1960	acyl-CoA dehydrogenase activity
C5746_RS23880	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS23885	COG1960	acyl-CoA dehydrogenase activity
C5746_RS23955	COG2226	methyltransferase
C5746_RS23970	COG1024	Enoyl-CoA hydratase
C5746_RS24005	COG2072	flavoprotein involved in K transport
C5746_RS24030	COG0501	Belongs to the peptidase M48B family
C5746_RS24050	COG1960	acyl-CoA dehydrogenase activity
C5746_RS24060	COG1309	transcriptional regulator
C5746_RS24070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5746_RS24070	COG0515	serine threonine protein kinase
C5746_RS24085	COG1024	Enoyl-CoA hydratase
C5746_RS24130	COG1278	Cold shock
C5746_RS24135	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C5746_RS24145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5746_RS24165	COG1595	DNA-templated transcription, initiation
C5746_RS24175	COG2226	methyltransferase
C5746_RS24195	COG0768	penicillin binding
C5746_RS24200	COG0583	DNA-binding transcription factor activity
C5746_RS24260	COG2815	serine threonine protein kinase
C5746_RS24260	COG0515	serine threonine protein kinase
C5746_RS24270	COG3103	Sh3 type 3 domain protein
C5746_RS24270	COG0791	NLP P60 protein
C5746_RS24270	COG1388	LysM domain
C5746_RS24280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24290	COG0649	NAD binding
C5746_RS24300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5746_RS24305	COG1034	ATP synthesis coupled electron transport
C5746_RS24310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5746_RS24315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24320	COG0839	Belongs to the complex I subunit 6 family
C5746_RS24325	COG0713	ATP synthesis coupled electron transport
C5746_RS24330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5746_RS24340	COG1007	ATP synthesis coupled electron transport
C5746_RS24345	COG0514	ATP-dependent DNA helicase (RecQ)
C5746_RS24355	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5746_RS24365	COG3104	oligopeptide transport
C5746_RS24370	COG0142	geranyltranstransferase activity
C5746_RS24385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5746_RS24390	COG0531	amino acid
C5746_RS24395	COG1349	DNA-binding transcription factor activity
C5746_RS24405	COG1131	(ABC) transporter
C5746_RS24415	COG1309	transcriptional regulator
C5746_RS24420	COG0561	phosphatase activity
C5746_RS24445	COG0702	epimerase
C5746_RS24450	COG1733	regulation of RNA biosynthetic process
C5746_RS24455	COG0531	amino acid
C5746_RS24460	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5746_RS24465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5746_RS24465	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5746_RS24470	COG2197	response regulator
C5746_RS24495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5746_RS24515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5746_RS24520	COG0839	Belongs to the complex I subunit 6 family
C5746_RS24525	COG0713	ATP synthesis coupled electron transport
C5746_RS24540	COG1007	ATP synthesis coupled electron transport
C5746_RS24545	COG1970	mechanosensitive ion channel activity
C5746_RS24550	COG0501	Belongs to the peptidase M48B family
C5746_RS24565	COG2261	transglycosylase associated protein
C5746_RS24575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5746_RS24580	COG1666	GTP binding
C5746_RS24590	COG1683	Conserved Protein
C5746_RS24595	COG0702	epimerase
C5746_RS24615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5746_RS24620	COG2030	dehydratase
C5746_RS24635	COG0477	Major facilitator Superfamily
C5746_RS24640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5746_RS24660	COG0436	Aminotransferase
C5746_RS24680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5746_RS24685	COG0081	regulation of translation
C5746_RS24695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5746_RS24700	COG0222	ribosome binding
C5746_RS24710	COG0085	RNA polymerase activity
C5746_RS24715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5746_RS24745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5746_RS24750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5746_RS24755	COG0049	tRNA binding
C5746_RS24760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5746_RS24765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5746_RS24790	COG0051	transcription antitermination factor activity, RNA binding
C5746_RS24795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5746_RS24800	COG0088	Forms part of the polypeptide exit tunnel
C5746_RS24805	COG0089	rRNA binding
C5746_RS24810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5746_RS24815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5746_RS24820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5746_RS24825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5746_RS24830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5746_RS24835	COG0255	Belongs to the universal ribosomal protein uL29 family
C5746_RS24840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5746_RS24845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5746_RS24850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5746_RS24855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5746_RS24860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5746_RS24870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5746_RS24875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5746_RS24880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5746_RS24885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5746_RS24890	COG1841	ribosomal large subunit assembly
C5746_RS24895	COG0200	Binds to the 23S rRNA
C5746_RS24905	COG0563	adenylate kinase activity
C5746_RS24915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5746_RS24920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5746_RS24925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5746_RS24930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5746_RS24935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5746_RS24940	COG0202	RNA polymerase activity
C5746_RS24945	COG0203	ribosomal protein L17
C5746_RS24950	COG0101	tRNA pseudouridine synthase activity
C5746_RS24960	COG0488	(ABC) transporter
C5746_RS24970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5746_RS24975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5746_RS24980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5746_RS24990	COG1072	(Pantothenic acid kinase))
C5746_RS25025	COG2318	DinB family
C5746_RS25050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS25055	COG0736	holo-[acyl-carrier-protein] synthase activity
C5746_RS25065	COG3189	MarR family transcriptional regulator
C5746_RS25070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5746_RS25080	COG0802	atpase or kinase
C5746_RS25105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5746_RS25130	COG4941	Belongs to the sigma-70 factor family
C5746_RS25140	COG2226	methyltransferase
C5746_RS25160	COG0726	polysaccharide deacetylase
C5746_RS25205	COG1609	Transcriptional regulator
C5746_RS25215	COG4221	oxidoreductase activity
C5746_RS25225	COG0583	DNA-binding transcription factor activity
C5746_RS25235	COG2197	response regulator
C5746_RS25240	COG1595	DNA-templated transcription, initiation
C5746_RS25250	COG0516	GMP reductase activity
C5746_RS25265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5746_RS25285	COG0515	serine threonine protein kinase
C5746_RS25290	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS25315	COG0519	Catalyzes the synthesis of GMP from XMP
C5746_RS25315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5746_RS25350	COG2197	response regulator
C5746_RS25360	COG0791	NLP P60 protein
C5746_RS25380	COG0739	heme binding
C5746_RS25390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS25410	COG0714	Associated with various cellular activities
C5746_RS25420	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5746_RS25425	COG0045	succinate-CoA ligase (ADP-forming) activity
C5746_RS25455	COG0138	bifunctional purine biosynthesis protein purh
C5746_RS25465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5746_RS25480	COG0039	L-malate dehydrogenase activity
C5746_RS25495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5746_RS25500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5746_RS25505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5746_RS25520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5746_RS25525	COG0180	Tryptophanyl-tRNA synthetase
C5746_RS25555	COG1408	metallophosphoesterase
C5746_RS25595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5746_RS25610	COG2009	succinate dehydrogenase
C5746_RS25620	COG3064	Membrane
C5746_RS25620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5746_RS25620	COG3583	domain protein
C5746_RS25640	COG4585	Histidine kinase
C5746_RS25645	COG2197	response regulator
C5746_RS25670	COG1595	DNA-templated transcription, initiation
C5746_RS25685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS25685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS25700	COG1216	Glycosyl transferase, family 2
C5746_RS25730	COG1083	cytidylyl-transferase
C5746_RS25735	COG2089	acid synthase
C5746_RS25760	COG1473	amidohydrolase
C5746_RS25760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5746_RS25765	COG1744	ABC transporter substrate-binding protein PnrA-like
C5746_RS25770	COG3845	ABC transporter
C5746_RS25775	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5746_RS25780	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5746_RS25800	COG1404	Belongs to the peptidase S8 family
C5746_RS25830	COG2814	Major facilitator Superfamily
C5746_RS25835	COG0583	DNA-binding transcription factor activity
C5746_RS25845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5746_RS25870	COG2205	protein histidine kinase activity
C5746_RS25875	COG0745	RESPONSE REGULATOR receiver
C5746_RS25880	COG1595	DNA-templated transcription, initiation
C5746_RS25895	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS25900	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS25905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5746_RS25920	COG0697	spore germination
C5746_RS25945	COG2252	PERMEase
C5746_RS25955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5746_RS25985	COG4770	biotin carboxylase activity
C5746_RS25995	COG0424	maF-like protein
C5746_RS26005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5746_RS26020	COG1024	Enoyl-CoA hydratase
C5746_RS26055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5746_RS26065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5746_RS26075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS26105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5746_RS26110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5746_RS26150	COG3251	PFAM MbtH domain protein
C5746_RS26160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS26165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS26200	COG0142	geranyltranstransferase activity
C5746_RS26225	COG1376	ErfK ybiS ycfS ynhG family protein
C5746_RS26235	COG1136	(ABC) transporter
C5746_RS26255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5746_RS26265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5746_RS26310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5746_RS26320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5746_RS26330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5746_RS26345	COG1331	Highly conserved protein containing a thioredoxin domain
C5746_RS26350	COG1309	transcriptional regulator
C5746_RS26355	COG0477	Major facilitator Superfamily
C5746_RS26365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C5746_RS26395	COG3437	response regulator, receiver
C5746_RS26400	COG3850	Histidine kinase
C5746_RS26400	COG3437	response regulator, receiver
C5746_RS26400	COG2205	protein histidine kinase activity
C5746_RS26400	COG4999	Histidine kinase
C5746_RS26430	COG3708	Transcriptional regulator
C5746_RS26430	COG2207	Transcriptional regulator
C5746_RS26450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5746_RS26465	COG1414	Transcriptional regulator
C5746_RS26470	COG0251	oxidation-reduction process
C5746_RS26500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5746_RS26500	COG0515	serine threonine protein kinase
C5746_RS26520	COG2894	cell division
C5746_RS26550	COG3920	Histidine kinase
C5746_RS26575	COG2885	chlorophyll binding
C5746_RS26665	COG2208	phosphoserine phosphatase activity
C5746_RS26665	COG2770	Histidine kinase
C5746_RS26675	COG2318	DinB family
C5746_RS26710	COG0531	amino acid
C5746_RS26760	COG0667	Aldo Keto reductase
C5746_RS26765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5746_RS26770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5746_RS26785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5746_RS26790	COG0450	alkyl hydroperoxide reductase
C5746_RS26805	COG1136	(ABC) transporter
C5746_RS26825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS26845	COG0114	fumarate hydratase activity
C5746_RS26855	COG1362	aminopeptidase activity
C5746_RS26870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5746_RS26870	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5746_RS26895	COG0778	Nitroreductase
C5746_RS26905	COG1722	exodeoxyribonuclease VII activity
C5746_RS26910	COG1570	exodeoxyribonuclease VII activity
C5746_RS26920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5746_RS26935	COG0012	GTP binding
C5746_RS27015	COG1842	Phage shock protein A
C5746_RS27040	COG0395	ABC-type sugar transport system, permease component
C5746_RS27045	COG1175	transmembrane transport
C5746_RS27055	COG3458	cephalosporin-C deacetylase activity
C5746_RS27075	COG1217	gtp-binding protein TYPA
C5746_RS27085	COG0747	negative chemotaxis
C5746_RS27090	COG0601	transmembrane transport
C5746_RS27095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS27100	COG0444	Belongs to the ABC transporter superfamily
C5746_RS27105	COG4608	Belongs to the ABC transporter superfamily
C5746_RS27110	COG4608	Belongs to the ABC transporter superfamily
C5746_RS27115	COG0444	Belongs to the ABC transporter superfamily
C5746_RS27125	COG4166	transmembrane transport
C5746_RS27130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS27140	COG0601	transmembrane transport
C5746_RS27145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS27155	COG4608	Belongs to the ABC transporter superfamily
C5746_RS27175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5746_RS27195	COG1131	(ABC) transporter
C5746_RS27205	COG4585	Histidine kinase
C5746_RS27210	COG2197	response regulator
C5746_RS27265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5746_RS27275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5746_RS27285	COG0519	Catalyzes the synthesis of GMP from XMP
C5746_RS27290	COG1024	Enoyl-CoA hydratase
C5746_RS27305	COG1595	DNA-templated transcription, initiation
C5746_RS27315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5746_RS27320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5746_RS27355	COG0598	Magnesium transport protein CorA
C5746_RS27370	COG2814	Major facilitator Superfamily
C5746_RS27385	COG2095	MarC family integral membrane protein
C5746_RS27395	COG1432	Conserved Protein
C5746_RS27445	COG0747	negative chemotaxis
C5746_RS27455	COG0601	transmembrane transport
C5746_RS27520	COG0210	DNA helicase
C5746_RS27565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5746_RS27615	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5746_RS27625	COG1615	UPF0182 protein
C5746_RS27665	COG0753	catalase activity
C5746_RS27675	COG0483	inositol monophosphate 1-phosphatase activity
C5746_RS27685	COG2076	Multidrug Resistance protein
C5746_RS27690	COG1162	GTPase activity
C5746_RS27695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5746_RS27705	COG2135	peptidase activity
C5746_RS27715	COG1595	DNA-templated transcription, initiation
C5746_RS27720	COG5662	AntiSigma factor
C5746_RS27725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C5746_RS27725	COG2199	diguanylate cyclase activity
C5746_RS27740	COG0242	peptide deformylase activity
C5746_RS27780	COG2188	Transcriptional regulator
C5746_RS27785	COG2182	Extracellular solute-binding protein
C5746_RS27790	COG1175	transmembrane transport
C5746_RS27795	COG0395	ABC-type sugar transport system, permease component
C5746_RS27800	COG1472	Belongs to the glycosyl hydrolase 3 family
C5746_RS27805	COG0363	glucosamine-6-phosphate deaminase activity
C5746_RS27810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS27825	COG1597	lipid kinase activity
C5746_RS27840	COG2172	sigma factor antagonist activity
C5746_RS27855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5746_RS27865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5746_RS27865	COG1017	nitric oxide dioxygenase activity
C5746_RS27870	COG1959	2 iron, 2 sulfur cluster binding
C5746_RS27875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5746_RS27880	COG0142	geranyltranstransferase activity
C5746_RS27905	COG5640	endopeptidase activity
C5746_RS27965	COG4106	trans-aconitate 2-methyltransferase activity
C5746_RS27970	COG1595	DNA-templated transcription, initiation
C5746_RS27980	COG1126	abc transporter atp-binding protein
C5746_RS27985	COG0765	amino acid transport
C5746_RS27990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS27995	COG0281	malic enzyme
C5746_RS28005	COG0604	alcohol dehydrogenase
C5746_RS28085	COG0567	Dehydrogenase, E1 component
C5746_RS28085	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5746_RS28095	COG2205	protein histidine kinase activity
C5746_RS28100	COG0745	RESPONSE REGULATOR receiver
C5746_RS28120	COG1131	(ABC) transporter
C5746_RS28130	COG1595	DNA-templated transcription, initiation
C5746_RS28135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5746_RS28140	COG0726	polysaccharide deacetylase
C5746_RS28160	COG5002	protein histidine kinase activity
C5746_RS28185	COG3883	PFAM NLP P60 protein
C5746_RS28185	COG0791	NLP P60 protein
C5746_RS28200	COG1309	transcriptional regulator
C5746_RS28215	COG2267	carboxylic ester hydrolase activity
C5746_RS28235	COG0768	penicillin binding
C5746_RS28245	COG2205	protein histidine kinase activity
C5746_RS28270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5746_RS28305	COG1201	RNA secondary structure unwinding
C5746_RS28415	COG0018	arginyl-trna synthetase
C5746_RS28420	COG0019	diaminopimelate decarboxylase activity
C5746_RS28425	COG0460	homoserine dehydrogenase
C5746_RS28430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5746_RS28435	COG0083	homoserine kinase activity
C5746_RS28445	COG1316	TRANSCRIPTIONal
C5746_RS28450	COG0254	rRNA binding
C5746_RS28455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5746_RS28460	COG2890	protein-(glutamine-N5) methyltransferase activity
C5746_RS28470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5746_RS28475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5746_RS28495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5746_RS28500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5746_RS28505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5746_RS28510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5746_RS28515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5746_RS28520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5746_RS28525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5746_RS28540	COG2197	response regulator
C5746_RS28565	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS28580	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C5746_RS28635	COG0183	Belongs to the thiolase family
C5746_RS28660	COG0745	RESPONSE REGULATOR receiver
C5746_RS28665	COG5002	protein histidine kinase activity
C5746_RS28665	COG5000	phosphorelay sensor kinase activity
C5746_RS28720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS28720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS28765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5746_RS28770	COG0857	belongs to the CobB CobQ family
C5746_RS28770	COG0280	phosphate acetyltransferase
C5746_RS28775	COG0205	6-phosphofructokinase activity
C5746_RS28790	COG4565	transcriptional regulatory protein
C5746_RS28795	COG3290	protein histidine kinase activity
C5746_RS28800	COG1301	dicarboxylic acid transport
C5746_RS28810	COG3118	belongs to the thioredoxin family
C5746_RS28840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5746_RS28840	COG4106	trans-aconitate 2-methyltransferase activity
C5746_RS28845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5746_RS28875	COG3973	AAA domain
C5746_RS28880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5746_RS28890	COG0366	Alpha amylase catalytic
C5746_RS28895	COG0366	Alpha amylase catalytic
C5746_RS28900	COG0058	SHG alpha-glucan phosphorylase activity
C5746_RS28915	COG0477	Major facilitator Superfamily
C5746_RS28930	COG1132	(ABC) transporter
C5746_RS28935	COG1132	(ABC) transporter
C5746_RS28940	COG1131	(ABC) transporter
C5746_RS28955	COG2197	response regulator
C5746_RS28980	COG0726	polysaccharide deacetylase
C5746_RS29000	COG2272	Belongs to the type-B carboxylesterase lipase family
C5746_RS29005	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS29025	COG1674	ftsk spoiiie
C5746_RS29080	COG1760	l-serine dehydratase
C5746_RS29085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5746_RS29090	COG0509	glycine decarboxylation via glycine cleavage system
C5746_RS29095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5746_RS29115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS29120	COG0747	negative chemotaxis
C5746_RS29130	COG0444	Belongs to the ABC transporter superfamily
C5746_RS29135	COG4608	Belongs to the ABC transporter superfamily
C5746_RS29140	COG2860	membrane
C5746_RS29205	COG0482	sulfurtransferase activity
C5746_RS29255	COG1611	Belongs to the LOG family
C5746_RS29260	COG4221	oxidoreductase activity
C5746_RS29270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5746_RS29280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5746_RS29285	COG0154	amidase activity
C5746_RS29295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5746_RS29300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5746_RS29315	COG2409	Drug exporters of the RND superfamily
C5746_RS29335	COG2197	response regulator
C5746_RS29340	COG2133	pyrroloquinoline quinone binding
C5746_RS29345	COG0667	Aldo Keto reductase
C5746_RS29365	COG0440	acetolactate synthase activity
C5746_RS29370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5746_RS29375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5746_RS29385	COG2508	Transcriptional regulator
C5746_RS29390	COG0506	proline dehydrogenase activity
C5746_RS29395	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS29405	COG1082	Xylose isomerase domain protein TIM barrel
C5746_RS29420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5746_RS29435	COG0473	3-isopropylmalate dehydrogenase activity
C5746_RS29440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5746_RS29445	COG0832	Belongs to the urease beta subunit family
C5746_RS29445	COG0831	urea catabolic process
C5746_RS29450	COG0804	urea catabolic process
C5746_RS29455	COG2957	Belongs to the agmatine deiminase family
C5746_RS29465	COG0477	Major facilitator Superfamily
C5746_RS29470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5746_RS29530	COG3226	Transcriptional regulator
C5746_RS29585	COG0366	Alpha amylase catalytic
C5746_RS29585	COG1470	cell adhesion involved in biofilm formation
C5746_RS29595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5746_RS29615	COG2018	Roadblock/LC7 domain
C5746_RS29635	COG2018	Roadblock/LC7 domain
C5746_RS29640	COG5002	protein histidine kinase activity
C5746_RS29650	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5746_RS29655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5746_RS29700	COG1414	Transcriptional regulator
C5746_RS29705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5746_RS29710	COG0066	3-isopropylmalate dehydratase activity
C5746_RS29720	COG0776	regulation of translation
C5746_RS29730	COG1920	GTP binding
C5746_RS29740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5746_RS29745	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5746_RS29770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5746_RS29775	COG1461	Dihydroxyacetone kinase
C5746_RS29780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5746_RS29785	COG0742	ribosomal rna small subunit methyltransferase
C5746_RS29790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5746_RS29805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5746_RS29810	COG0571	ribonuclease III activity
C5746_RS29815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5746_RS29820	COG1733	regulation of RNA biosynthetic process
C5746_RS29835	COG1254	Belongs to the acylphosphatase family
C5746_RS29850	COG1196	nuclear chromosome segregation
C5746_RS29855	COG0477	Major facilitator Superfamily
C5746_RS29865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5746_RS29895	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C5746_RS29905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5746_RS29910	COG3457	Alanine racemase
C5746_RS29915	COG0626	cystathionine gamma-synthase activity
C5746_RS29920	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C5746_RS29940	COG2188	Transcriptional regulator
C5746_RS29945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5746_RS29955	COG0442	prolyl-tRNA aminoacylation
C5746_RS29965	COG0228	four-way junction DNA binding
C5746_RS29970	COG1837	Belongs to the UPF0109 family
C5746_RS29975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5746_RS29980	COG0336	Belongs to the RNA methyltransferase TrmD family
C5746_RS29985	COG0335	large ribosomal subunit rRNA binding
C5746_RS30005	COG0681	Belongs to the peptidase S26 family
C5746_RS30020	COG0792	nuclease activity
C5746_RS30035	COG1191	sigma factor activity
C5746_RS30050	COG0052	Belongs to the universal ribosomal protein uS2 family
C5746_RS30055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5746_RS30060	COG0528	UMP kinase activity
C5746_RS30065	COG0233	cytoplasmic translational termination
C5746_RS30070	COG0575	Belongs to the CDS family
C5746_RS30090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5746_RS30105	COG3842	ATPase activity
C5746_RS30125	COG1136	(ABC) transporter
C5746_RS30130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5746_RS30140	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS30160	COG2197	response regulator
C5746_RS30165	COG4585	Histidine kinase
C5746_RS30180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5746_RS30195	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS30205	COG3842	ATPase activity
C5746_RS30210	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5746_RS30215	COG1177	transmembrane transport
C5746_RS30220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS30235	COG1215	transferase activity, transferring glycosyl groups
C5746_RS30265	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS30295	COG1073	alpha beta
C5746_RS30320	COG2770	Histidine kinase
C5746_RS30320	COG2208	phosphoserine phosphatase activity
C5746_RS30365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5746_RS30370	COG0750	zinc metalloprotease
C5746_RS30375	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5746_RS30385	COG0456	acetyltransferase
C5746_RS30390	COG0442	prolyl-tRNA aminoacylation
C5746_RS30410	COG0779	Required for maturation of 30S ribosomal subunits
C5746_RS30425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5746_RS30435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5746_RS30440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5746_RS30465	COG4608	Belongs to the ABC transporter superfamily
C5746_RS30470	COG0444	Belongs to the ABC transporter superfamily
C5746_RS30475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS30480	COG0601	transmembrane transport
C5746_RS30485	COG0747	negative chemotaxis
C5746_RS30490	COG0455	bacterial-type flagellum organization
C5746_RS30510	COG1404	Belongs to the peptidase S8 family
C5746_RS30530	COG1674	ftsk spoiiie
C5746_RS30540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5746_RS30545	COG1185	polyribonucleotide nucleotidyltransferase activity
C5746_RS30550	COG0612	Peptidase, M16
C5746_RS30555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5746_RS30575	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5746_RS30580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5746_RS30585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5746_RS30620	COG0784	Response regulator, receiver
C5746_RS30620	COG2205	protein histidine kinase activity
C5746_RS30630	COG1674	ftsk spoiiie
C5746_RS30640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5746_RS30650	COG1546	Belongs to the CinA family
C5746_RS30650	COG1058	Belongs to the CinA family
C5746_RS30655	COG1396	sequence-specific DNA binding
C5746_RS30665	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS30670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5746_RS30675	COG1201	RNA secondary structure unwinding
C5746_RS30680	COG1917	Cupin 2, conserved barrel domain protein
C5746_RS30680	COG2207	Transcriptional regulator
C5746_RS30720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5746_RS30755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5746_RS30760	COG0765	amino acid transport
C5746_RS30765	COG0765	amino acid transport
C5746_RS30770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS30775	COG1126	abc transporter atp-binding protein
C5746_RS30785	COG0642	Histidine kinase
C5746_RS30795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5746_RS30810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5746_RS30820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5746_RS30825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5746_RS30835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5746_RS30875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5746_RS30880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5746_RS30885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5746_RS30910	COG0488	(ABC) transporter
C5746_RS30930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5746_RS30960	COG1129	ABC transporter
C5746_RS30965	COG1802	Transcriptional regulator
C5746_RS30970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5746_RS30995	COG4585	Histidine kinase
C5746_RS31000	COG2197	response regulator
C5746_RS31010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS31015	COG4565	transcriptional regulatory protein
C5746_RS31020	COG3290	protein histidine kinase activity
C5746_RS31030	COG0372	Belongs to the citrate synthase family
C5746_RS31035	COG0372	Belongs to the citrate synthase family
C5746_RS31045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5746_RS31050	COG0612	Peptidase, M16
C5746_RS31065	COG1802	Transcriptional regulator
C5746_RS31070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5746_RS31075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5746_RS31075	COG1042	CoA-binding domain protein
C5746_RS31075	COG0045	succinate-CoA ligase (ADP-forming) activity
C5746_RS31090	COG1435	thymidine kinase activity
C5746_RS31155	COG1674	ftsk spoiiie
C5746_RS31170	COG1404	Belongs to the peptidase S8 family
C5746_RS31175	COG0464	growth
C5746_RS31230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5746_RS31240	COG0745	RESPONSE REGULATOR receiver
C5746_RS31245	COG2205	protein histidine kinase activity
C5746_RS31270	COG0756	dUTP diphosphatase activity
C5746_RS31285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5746_RS31290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5746_RS31295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5746_RS31315	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5746_RS31315	COG1136	(ABC) transporter
C5746_RS31345	COG0569	domain protein
C5746_RS31350	COG1802	Transcriptional regulator
C5746_RS31355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5746_RS31360	COG0531	amino acid
C5746_RS31365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5746_RS31380	COG1335	isochorismatase
C5746_RS31385	COG2259	Doxx family
C5746_RS31390	COG0783	Belongs to the Dps family
C5746_RS31395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5746_RS31430	COG1653	transport
C5746_RS31435	COG1175	transmembrane transport
C5746_RS31440	COG0395	ABC-type sugar transport system, permease component
C5746_RS31445	COG2197	response regulator
C5746_RS31450	COG2267	carboxylic ester hydrolase activity
C5746_RS31455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS31520	COG2801	Transposase and inactivated derivatives
C5746_RS31535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5746_RS31540	COG3012	SEC-C Motif Domain Protein
C5746_RS31625	COG2197	response regulator
C5746_RS31630	COG4585	Histidine kinase
C5746_RS31640	COG2409	Drug exporters of the RND superfamily
C5746_RS31655	COG2977	Belongs to the P-Pant transferase superfamily
C5746_RS31670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5746_RS31675	COG1349	DNA-binding transcription factor activity
C5746_RS31685	COG0673	inositol 2-dehydrogenase activity
C5746_RS31720	COG1799	cell septum assembly
C5746_RS31745	COG2040	homocysteine
C5746_RS31750	COG2226	methyltransferase
C5746_RS31755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5746_RS31765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5746_RS31770	COG0531	amino acid
C5746_RS31780	COG1024	Enoyl-CoA hydratase
C5746_RS31815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5746_RS31815	COG2111	Na H antiporter
C5746_RS31820	COG1006	Multisubunit Na H antiporter MnhC subunit
C5746_RS31825	COG0651	ATP synthesis coupled electron transport
C5746_RS31840	COG1320	monovalent cation:proton antiporter activity
C5746_RS31875	COG2837	iron assimilation
C5746_RS32010	COG0151	Belongs to the GarS family
C5746_RS32050	COG1366	Belongs to the anti-sigma-factor antagonist family
C5746_RS32055	COG1366	Belongs to the anti-sigma-factor antagonist family
C5746_RS32115	COG1388	LysM domain
C5746_RS32115	COG3103	Sh3 type 3 domain protein
C5746_RS32115	COG0791	NLP P60 protein
C5746_RS32235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5746_RS32240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5746_RS32245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5746_RS32255	COG3903	Transcriptional regulator
C5746_RS32255	COG3629	intracellular signal transduction
C5746_RS32275	COG0588	phosphoglycerate mutase activity
C5746_RS32285	COG1653	transport
C5746_RS32290	COG1175	transmembrane transport
C5746_RS32295	COG0395	ABC-type sugar transport system, permease component
C5746_RS32300	COG1940	carbohydrate kinase activity
C5746_RS32305	COG4213	ABC transporter substrate-binding protein
C5746_RS32320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5746_RS32325	COG0531	amino acid
C5746_RS32335	COG1316	TRANSCRIPTIONal
C5746_RS32350	COG0438	transferase activity, transferring glycosyl groups
C5746_RS32360	COG0438	transferase activity, transferring glycosyl groups
C5746_RS32380	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS32380	COG1024	Enoyl-CoA hydratase
C5746_RS32385	COG0183	Belongs to the thiolase family
C5746_RS32405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5746_RS32410	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5746_RS32420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C5746_RS32425	COG3253	May function as heme-dependent peroxidase
C5746_RS32445	COG3220	belongs to the UPF0276 family
C5746_RS32465	COG4152	abc transporter atp-binding protein
C5746_RS32505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5746_RS32510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5746_RS32610	COG2197	response regulator
C5746_RS32615	COG4585	Histidine kinase
C5746_RS32620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5746_RS32630	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS32670	COG0395	ABC-type sugar transport system, permease component
C5746_RS32675	COG1175	transmembrane transport
C5746_RS32680	COG1653	transport
C5746_RS32685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5746_RS32730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5746_RS32755	COG1063	alcohol dehydrogenase
C5746_RS32760	COG0156	8-amino-7-oxononanoate synthase activity
C5746_RS32765	COG0583	DNA-binding transcription factor activity
C5746_RS32775	COG1136	(ABC) transporter
C5746_RS32785	COG2197	response regulator
C5746_RS32790	COG0346	lactoylglutathione lyase activity
C5746_RS32840	COG1716	ATPase activity
C5746_RS32915	COG1119	ATPase activity
C5746_RS32920	COG0667	Aldo Keto reductase
C5746_RS32930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5746_RS32940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5746_RS32945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5746_RS32965	COG0529	Catalyzes the synthesis of activated sulfate
C5746_RS32970	COG0175	sulfate reduction
C5746_RS32995	COG1960	acyl-CoA dehydrogenase activity
C5746_RS33015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS33025	COG0583	DNA-binding transcription factor activity
C5746_RS33030	COG0183	Belongs to the thiolase family
C5746_RS33045	COG0577	efflux transmembrane transporter activity
C5746_RS33050	COG1136	(ABC) transporter
C5746_RS33050	COG0577	efflux transmembrane transporter activity
C5746_RS33055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5746_RS33135	COG1162	GTPase activity
C5746_RS33170	COG1404	Belongs to the peptidase S8 family
C5746_RS33180	COG0028	Belongs to the TPP enzyme family
C5746_RS33195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5746_RS33195	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5746_RS33200	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5746_RS33210	COG3938	Belongs to the proline racemase family
C5746_RS33220	COG1802	Transcriptional regulator
C5746_RS33225	COG0006	proline dipeptidase activity
C5746_RS33230	COG3291	Pkd domain containing protein
C5746_RS33260	COG1802	Transcriptional regulator
C5746_RS33270	COG3835	regulator
C5746_RS33285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5746_RS33290	COG2252	PERMEase
C5746_RS33295	COG3608	succinylglutamate desuccinylase aspartoacylase
C5746_RS33295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5746_RS33315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5746_RS33345	COG0277	FAD linked oxidase domain protein
C5746_RS33350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5746_RS33360	COG2814	Major facilitator Superfamily
C5746_RS33370	COG3291	Pkd domain containing protein
C5746_RS33400	COG0640	Transcriptional regulator
C5746_RS33450	COG1278	Cold shock
C5746_RS33465	COG2197	response regulator
C5746_RS33470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5746_RS33475	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS33495	COG3960	tartronate-semialdehyde synthase activity
C5746_RS33510	COG0753	catalase activity
C5746_RS33515	COG2084	Dehydrogenase
C5746_RS33520	COG3622	Belongs to the hyi family
C5746_RS33525	COG2706	6-phosphogluconolactonase activity
C5746_RS33545	COG2351	hydroxyisourate hydrolase activity
C5746_RS33565	COG2233	PERMEase
C5746_RS33605	COG3864	Putative metallopeptidase domain
C5746_RS33670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5746_RS33685	COG2197	response regulator
C5746_RS33705	COG1414	Transcriptional regulator
C5746_RS33710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS33715	COG4266	Belongs to the allantoicase family
C5746_RS33725	COG0656	L-ascorbic acid biosynthetic process
C5746_RS33730	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS33750	COG2197	response regulator
C5746_RS33765	COG0673	inositol 2-dehydrogenase activity
C5746_RS33770	COG2188	Transcriptional regulator
C5746_RS33790	COG1129	ABC transporter
C5746_RS33795	COG1940	carbohydrate kinase activity
C5746_RS33820	COG0783	Belongs to the Dps family
C5746_RS33825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5746_RS33840	COG2814	Major facilitator Superfamily
C5746_RS33870	COG1335	isochorismatase
C5746_RS33875	COG2259	Doxx family
C5746_RS33910	COG3629	intracellular signal transduction
C5746_RS33910	COG3903	Transcriptional regulator
C5746_RS33925	COG2267	carboxylic ester hydrolase activity
C5746_RS33930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS33945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5746_RS33950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5746_RS33965	COG3540	Alkaline phosphatase
C5746_RS33975	COG1126	abc transporter atp-binding protein
C5746_RS33980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5746_RS33985	COG0765	amino acid transport
C5746_RS33990	COG0765	amino acid transport
C5746_RS34015	COG0745	RESPONSE REGULATOR receiver
C5746_RS34020	COG2205	protein histidine kinase activity
C5746_RS34040	COG0405	Gamma-glutamyltransferase
C5746_RS34070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5746_RS34080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5746_RS34085	COG0583	DNA-binding transcription factor activity
C5746_RS34105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS34115	COG1953	Uracil, thiamine, allantoin
C5746_RS34150	COG0095	Lipoate-protein ligase
C5746_RS34160	COG0659	secondary active sulfate transmembrane transporter activity
C5746_RS34170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5746_RS34215	COG0702	epimerase
C5746_RS34245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5746_RS34275	COG0483	inositol monophosphate 1-phosphatase activity
C5746_RS34300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5746_RS34310	COG0254	rRNA binding
C5746_RS34320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5746_RS34325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5746_RS34335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5746_RS34350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5746_RS34370	COG1929	Belongs to the glycerate kinase type-1 family
C5746_RS34400	COG0688	phosphatidylethanolamine metabolic process
C5746_RS34405	COG1960	acyl-CoA dehydrogenase activity
C5746_RS34415	COG2301	Belongs to the HpcH HpaI aldolase family
C5746_RS34420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS34420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5746_RS34425	COG0604	alcohol dehydrogenase
C5746_RS34440	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS34455	COG0596	Alpha beta hydrolase
C5746_RS34475	COG4106	trans-aconitate 2-methyltransferase activity
C5746_RS34485	COG0583	DNA-binding transcription factor activity
C5746_RS34490	COG0667	Aldo Keto reductase
C5746_RS34495	COG2318	DinB family
C5746_RS34500	COG0154	amidase activity
C5746_RS34525	COG2205	protein histidine kinase activity
C5746_RS34530	COG0745	RESPONSE REGULATOR receiver
C5746_RS34545	COG0577	efflux transmembrane transporter activity
C5746_RS34545	COG1136	(ABC) transporter
C5746_RS34550	COG1136	(ABC) transporter
C5746_RS34550	COG0577	efflux transmembrane transporter activity
C5746_RS34555	COG2318	DinB family
C5746_RS34570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C5746_RS34575	COG2362	D-Aminopeptidase
C5746_RS34580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5746_RS34590	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5746_RS34600	COG0367	asparagine synthase
C5746_RS34620	COG2226	methyltransferase
C5746_RS34635	COG1414	Transcriptional regulator
C5746_RS34660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5746_RS34685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5746_RS34700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5746_RS34700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5746_RS34715	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5746_RS34755	COG1960	acyl-CoA dehydrogenase activity
C5746_RS34760	COG1113	amino acid transport
C5746_RS34775	COG0656	L-ascorbic acid biosynthetic process
C5746_RS34795	COG3250	beta-galactosidase activity
C5746_RS34805	COG0583	DNA-binding transcription factor activity
C5746_RS34815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5746_RS34830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5746_RS34840	COG1349	DNA-binding transcription factor activity
C5746_RS34845	COG0494	nUDIX hydrolase
C5746_RS34850	COG1940	carbohydrate kinase activity
C5746_RS34850	COG1846	Transcriptional regulator
C5746_RS34855	COG1129	ABC transporter
C5746_RS34860	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5746_RS34865	COG1879	ABC-type sugar transport system periplasmic component
C5746_RS34870	COG0673	inositol 2-dehydrogenase activity
C5746_RS34890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5746_RS34940	COG1113	amino acid transport
C5746_RS34955	COG1609	Transcriptional regulator
C5746_RS34960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5746_RS34965	COG1609	Transcriptional regulator
C5746_RS34970	COG1957	nucleoside hydrolase
C5746_RS34975	COG0477	Major facilitator Superfamily
C5746_RS34985	COG0189	ligase activity
C5746_RS35035	COG2133	pyrroloquinoline quinone binding
C5746_RS35035	COG5183	chlorophyll binding
C5746_RS35045	COG2197	response regulator
C5746_RS35050	COG2409	Drug exporters of the RND superfamily
C5746_RS35075	COG2801	Transposase and inactivated derivatives
C5746_RS35105	COG5002	protein histidine kinase activity
C5746_RS35110	COG0745	RESPONSE REGULATOR receiver
C5746_RS35175	COG3511	phospholipase C
C5746_RS35190	COG0494	nUDIX hydrolase
C5746_RS35205	COG2124	cytochrome p450
C5746_RS35230	COG1940	carbohydrate kinase activity
C5746_RS35270	COG1289	transmembrane transporter activity
C5746_RS35280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5746_RS35310	COG1486	melibiose metabolic process
C5746_RS35380	COG4249	Peptidase C14 caspase catalytic subunit p20
C5746_RS35380	COG2319	Wd-40 repeat
C5746_RS35410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5746_RS35450	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5746_RS35455	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C5746_RS35460	COG0714	Associated with various cellular activities
C5746_RS35465	COG4884	unkown
C5746_RS35465	COG3831	ATPase activity
C5746_RS35535	COG3012	SEC-C Motif Domain Protein
C5746_RS35595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5746_RS35620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5746_RS35655	COG1793	dna ligase
C5746_RS35725	COG1515	deoxyribonuclease V activity
C5746_RS35735	COG3268	Saccharopine dehydrogenase
C5746_RS35740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5746_RS35745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS35750	COG1960	acyl-CoA dehydrogenase activity
C5746_RS35755	COG0183	Belongs to the thiolase family
C5746_RS35760	COG1024	Enoyl-CoA hydratase
C5746_RS35760	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5746_RS35765	COG0789	Transcriptional regulator
C5746_RS35815	COG2936	dipeptidyl-peptidase activity
C5746_RS35845	COG2183	response to ionizing radiation
C5746_RS35855	COG4977	sequence-specific DNA binding
C5746_RS35865	COG1024	Enoyl-CoA hydratase
C5746_RS35880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5746_RS35885	COG2226	methyltransferase
C5746_RS35910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5746_RS35930	COG1388	LysM domain
C5746_RS35930	COG1134	teichoic acid transport
C5746_RS35935	COG1562	ergosterol biosynthetic process
C5746_RS35945	COG1233	COG1233 Phytoene dehydrogenase and related
C5746_RS35955	COG1657	PFAM Prenyltransferase squalene oxidase
C5746_RS35970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5746_RS35975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5746_RS35990	COG2365	Tyrosine phosphatase family
C5746_RS36005	COG2755	lipolytic protein G-D-S-L family
C5746_RS36015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5746_RS36055	COG1309	transcriptional regulator
C5746_RS36060	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS36065	COG1960	acyl-CoA dehydrogenase activity
C5746_RS36080	COG1404	Belongs to the peptidase S8 family
C5746_RS36100	COG3467	pyridoxamine 5'-phosphate
C5746_RS36155	COG1609	Transcriptional regulator
C5746_RS36165	COG4209	transmembrane transport
C5746_RS36170	COG0395	ABC-type sugar transport system, permease component
C5746_RS36190	COG1609	Transcriptional regulator
C5746_RS36195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5746_RS36205	COG1116	anion transmembrane transporter activity
C5746_RS36225	COG3507	Belongs to the glycosyl hydrolase 43 family
C5746_RS36230	COG3958	Transketolase
C5746_RS36235	COG3959	Transketolase, thiamine diphosphate binding domain
C5746_RS36265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5746_RS36290	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS36295	COG1024	Enoyl-CoA hydratase
C5746_RS36300	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5746_RS36310	COG0247	lactate metabolic process
C5746_RS36315	COG1139	Iron-sulfur cluster binding protein
C5746_RS36320	COG1556	Lactate utilization protein
C5746_RS36355	COG2814	Major facilitator Superfamily
C5746_RS36425	COG2329	Antibiotic biosynthesis monooxygenase
C5746_RS36445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5746_RS36455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5746_RS36510	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5746_RS36510	COG1902	pentaerythritol trinitrate reductase activity
C5746_RS36530	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS36555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS36560	COG0601	transmembrane transport
C5746_RS36565	COG0747	negative chemotaxis
C5746_RS36575	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5746_RS36580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5746_RS36615	COG0745	RESPONSE REGULATOR receiver
C5746_RS36620	COG2205	protein histidine kinase activity
C5746_RS36645	COG1401	restriction endodeoxyribonuclease activity
C5746_RS36660	COG1401	restriction endodeoxyribonuclease activity
C5746_RS36685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5746_RS36715	COG0517	IMP dehydrogenase activity
C5746_RS36715	COG0617	tRNA 3'-terminal CCA addition
C5746_RS36715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5746_RS36790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5746_RS36830	COG2837	iron assimilation
C5746_RS36835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5746_RS36845	COG0596	Alpha beta hydrolase
C5746_RS36875	COG4251	negative regulation of phosphorylation
C5746_RS36915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS36920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS36975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5746_RS36980	COG3275	phosphorelay sensor kinase activity
C5746_RS37000	COG0531	amino acid
C5746_RS37045	COG0583	DNA-binding transcription factor activity
C5746_RS37055	COG1053	succinate dehydrogenase
C5746_RS37060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5746_RS37090	COG3360	Dodecin
C5746_RS37095	COG2182	Extracellular solute-binding protein
C5746_RS37110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C5746_RS37115	COG0121	glutamine amidotransferase
C5746_RS37120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5746_RS37125	COG3572	ergothioneine biosynthetic process
C5746_RS37140	COG2268	Band 7 protein
C5746_RS37150	COG1609	Transcriptional regulator
C5746_RS37160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5746_RS37170	COG4608	Belongs to the ABC transporter superfamily
C5746_RS37220	COG2239	Acts as a magnesium transporter
C5746_RS37235	COG0477	Major facilitator Superfamily
C5746_RS37270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5746_RS37280	COG0154	amidase activity
C5746_RS37300	COG0009	L-threonylcarbamoyladenylate synthase
C5746_RS37365	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
C5746_RS37420	COG4948	Mandelate Racemase Muconate Lactonizing
C5746_RS37445	COG2814	Major facilitator Superfamily
C5746_RS37455	COG1174	glycine betaine transport
C5746_RS37460	COG1174	glycine betaine transport
C5746_RS37475	COG3458	cephalosporin-C deacetylase activity
C5746_RS37490	COG0517	IMP dehydrogenase activity
C5746_RS37490	COG1125	glycine betaine transport
C5746_RS37500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5746_RS37505	COG1937	Protein conserved in bacteria
C5746_RS37520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5746_RS37520	COG3291	Pkd domain containing protein
C5746_RS37530	COG1960	acyl-CoA dehydrogenase activity
C5746_RS37535	COG1960	acyl-CoA dehydrogenase activity
C5746_RS37550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS37555	COG0444	Belongs to the ABC transporter superfamily
C5746_RS37560	COG1124	(ABC) transporter
C5746_RS37575	COG3973	AAA domain
C5746_RS37580	COG1819	glycosyl
C5746_RS37605	COG0596	Alpha beta hydrolase
C5746_RS37625	COG3290	protein histidine kinase activity
C5746_RS37635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5746_RS37640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5746_RS37650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5746_RS37655	COG1024	Enoyl-CoA hydratase
C5746_RS37655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5746_RS37695	COG0375	protein maturation
C5746_RS37700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5746_RS37705	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5746_RS37710	COG0298	carbon dioxide binding
C5746_RS37720	COG0309	Hydrogenase expression formation protein (HypE)
C5746_RS37725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5746_RS37740	COG2226	methyltransferase
C5746_RS37750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS37760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5746_RS37765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5746_RS37800	COG0488	(ABC) transporter
C5746_RS37845	COG3511	phospholipase C
C5746_RS37850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5746_RS37875	COG0673	inositol 2-dehydrogenase activity
C5746_RS37900	COG1233	COG1233 Phytoene dehydrogenase and related
C5746_RS37905	COG2130	NADP-dependent
C5746_RS37915	COG2124	cytochrome p450
C5746_RS37925	COG0588	phosphoglycerate mutase activity
C5746_RS37935	COG3290	protein histidine kinase activity
C5746_RS37950	COG2124	cytochrome p450
C5746_RS37970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS37980	COG2192	nodulation
C5746_RS37990	COG3903	Transcriptional regulator
C5746_RS37990	COG3629	intracellular signal transduction
C5746_RS38025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5746_RS38040	COG0137	argininosuccinate synthase activity
C5746_RS38045	COG4585	Histidine kinase
C5746_RS38050	COG2197	response regulator
C5746_RS38090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5746_RS38105	COG0166	Belongs to the GPI family
C5746_RS38110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5746_RS38150	COG1522	sequence-specific DNA binding
C5746_RS38155	COG3386	PFAM SMP-30 Gluconolaconase
C5746_RS38180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5746_RS38190	COG0747	negative chemotaxis
C5746_RS38195	COG1609	Transcriptional regulator
C5746_RS38220	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS38230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS38245	COG1404	Belongs to the peptidase S8 family
C5746_RS38270	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS38285	COG3246	L-lysine catabolic process to acetate
C5746_RS38295	COG2175	clavaminate synthase activity
C5746_RS38300	COG0477	Major facilitator Superfamily
C5746_RS38345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5746_RS38360	COG2124	cytochrome p450
C5746_RS38370	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS38375	COG0019	diaminopimelate decarboxylase activity
C5746_RS38395	COG3321	synthase
C5746_RS38395	COG0604	alcohol dehydrogenase
C5746_RS38395	COG3321	synthase
C5746_RS38395	COG0604	alcohol dehydrogenase
C5746_RS38410	COG0477	Major facilitator Superfamily
C5746_RS38415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS38465	COG0604	alcohol dehydrogenase
C5746_RS38465	COG3321	synthase
C5746_RS38470	COG3321	synthase
C5746_RS38470	COG0604	alcohol dehydrogenase
C5746_RS38475	COG3321	synthase
C5746_RS38475	COG0604	alcohol dehydrogenase
C5746_RS38480	COG3321	synthase
C5746_RS38480	COG0604	alcohol dehydrogenase
C5746_RS38485	COG2267	carboxylic ester hydrolase activity
C5746_RS38500	COG4585	Histidine kinase
C5746_RS38505	COG2197	response regulator
C5746_RS38525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS38530	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS38535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5746_RS38540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5746_RS38550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5746_RS38560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5746_RS38565	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C5746_RS38570	COG1960	acyl-CoA dehydrogenase activity
C5746_RS38575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS38590	COG1024	Enoyl-CoA hydratase
C5746_RS38605	COG0475	glutathione-regulated potassium exporter activity
C5746_RS38620	COG0604	alcohol dehydrogenase
C5746_RS38625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS38635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5746_RS38660	COG1819	glycosyl
C5746_RS38665	COG1819	glycosyl
C5746_RS38700	COG1937	Protein conserved in bacteria
C5746_RS38705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5746_RS38705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5746_RS38715	COG0730	response to heat
C5746_RS38740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C5746_RS38755	COG3321	synthase
C5746_RS38755	COG0604	alcohol dehydrogenase
C5746_RS38760	COG2070	2-Nitropropane dioxygenase
C5746_RS38760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5746_RS38780	COG0492	ferredoxin-NADP+ reductase activity
C5746_RS38785	COG1131	(ABC) transporter
C5746_RS38895	COG1063	alcohol dehydrogenase
C5746_RS38960	COG2124	cytochrome p450
C5746_RS38970	COG0142	geranyltranstransferase activity
C5746_RS39005	COG2192	nodulation
C5746_RS39015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5746_RS39025	COG3321	synthase
C5746_RS39025	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS39025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS39025	COG0318	PFAM AMP-dependent synthetase and ligase
C5746_RS39025	COG0300	oxidoreductase activity
C5746_RS39045	COG4941	Belongs to the sigma-70 factor family
C5746_RS39055	COG0154	amidase activity
C5746_RS39060	COG0596	Alpha beta hydrolase
C5746_RS39105	COG0431	NADPH-dependent FMN reductase
C5746_RS39210	COG0006	proline dipeptidase activity
C5746_RS39215	COG0006	proline dipeptidase activity
C5746_RS39235	COG0154	amidase activity
C5746_RS39250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5746_RS39265	COG3250	beta-galactosidase activity
C5746_RS39275	COG0640	Transcriptional regulator
C5746_RS39295	COG1653	transport
C5746_RS39300	COG3833	ABC-type maltose transport systems, permease component
C5746_RS39310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5746_RS39315	COG1414	Transcriptional regulator
C5746_RS39340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5746_RS39350	COG2205	protein histidine kinase activity
C5746_RS39355	COG0745	RESPONSE REGULATOR receiver
C5746_RS39365	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5746_RS39365	COG3291	Pkd domain containing protein
C5746_RS39380	COG0657	acetylesterase activity
C5746_RS39400	COG0235	Class ii aldolase
C5746_RS39425	COG2175	clavaminate synthase activity
C5746_RS39435	COG0640	Transcriptional regulator
C5746_RS39460	COG0515	serine threonine protein kinase
C5746_RS39465	COG1051	belongs to the nudix hydrolase family
C5746_RS39480	COG0659	secondary active sulfate transmembrane transporter activity
C5746_RS39500	COG2824	Alkylphosphonate utilization operon protein PhnA
C5746_RS39565	COG0789	Transcriptional regulator
C5746_RS39570	COG2801	Transposase and inactivated derivatives
C5746_RS39575	COG2826	transposase and inactivated derivatives, IS30 family
C5746_RS39585	COG2963	transposase activity
C5746_RS39595	COG1595	DNA-templated transcription, initiation
C5746_RS39645	COG3629	intracellular signal transduction
C5746_RS39645	COG3903	Transcriptional regulator
C5746_RS39655	COG1132	(ABC) transporter
C5746_RS39670	COG2124	cytochrome p450
C5746_RS39685	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS39690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5746_RS39690	COG2022	thiamine diphosphate biosynthetic process
C5746_RS39695	COG4608	Belongs to the ABC transporter superfamily
C5746_RS39700	COG0444	Belongs to the ABC transporter superfamily
C5746_RS39705	COG0601	transmembrane transport
C5746_RS39965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5746_RS40160	COG1136	(ABC) transporter
C5746_RS40160	COG0577	efflux transmembrane transporter activity
C5746_RS40195	COG0714	Associated with various cellular activities
C5746_RS40215	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5746_RS40225	COG1120	ATPase activity
C5746_RS40230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5746_RS40260	COG0583	DNA-binding transcription factor activity
C5746_RS40290	COG1136	(ABC) transporter
C5746_RS40415	COG4865	methylaspartate mutase activity
C5746_RS40420	COG0017	Asparaginyl-tRNA synthetase
C5746_RS40425	COG0069	glutamate synthase activity
C5746_RS40430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5746_RS40435	COG2423	ornithine cyclodeaminase activity
C5746_RS40550	COG1113	amino acid transport
C5746_RS40555	COG0251	oxidation-reduction process
C5746_RS40560	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C5746_RS40560	COG2508	Transcriptional regulator
C5746_RS40585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS40610	COG1695	Transcriptional regulator
C5746_RS40645	COG4585	Histidine kinase
C5746_RS40650	COG2197	response regulator
C5746_RS40775	COG3655	Transcriptional regulator
C5746_RS40805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5746_RS40880	COG0596	Alpha beta hydrolase
C5746_RS40885	COG1476	TRANSCRIPTIONal
C5746_RS40895	COG4249	Peptidase C14 caspase catalytic subunit p20
C5746_RS40895	COG2319	Wd-40 repeat
C5746_RS40940	COG2801	Transposase and inactivated derivatives
C5746_RS40945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C5746_RS40985	COG1012	belongs to the aldehyde dehydrogenase family
C5746_RS41015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5746_RS41020	COG3239	Fatty acid desaturase
C5746_RS41065	COG2018	Roadblock/LC7 domain
C5746_RS41080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5746_RS41085	COG1316	TRANSCRIPTIONal
C5746_RS41095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5746_RS41100	COG0640	Transcriptional regulator
C5746_RS41110	COG2018	Roadblock/LC7 domain
C5746_RS41135	COG1024	Enoyl-CoA hydratase
C5746_RS41145	COG1070	Carbohydrate kinase
C5746_RS41150	COG3347	Dehydrogenase
C5746_RS41150	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS41155	COG4952	isomerase
C5746_RS41180	COG1357	PFAM Pentapeptide repeats (8 copies)
C5746_RS41195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5746_RS41230	COG2801	Transposase and inactivated derivatives
C5746_RS41270	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS41285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5746_RS41290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5746_RS41295	COG2080	2 iron, 2 sulfur cluster binding
C5746_RS41310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5746_RS41325	COG1349	DNA-binding transcription factor activity
C5746_RS41425	COG2188	Transcriptional regulator
C5746_RS41430	COG0402	S-adenosylhomocysteine deaminase activity
C5746_RS41435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5746_RS41530	COG2801	Transposase and inactivated derivatives
C5746_RS41545	COG1335	isochorismatase
C5746_RS41560	COG2801	Transposase and inactivated derivatives
C5746_RS41610	COG0181	hydroxymethylbilane synthase activity
C5746_RS41625	COG2267	carboxylic ester hydrolase activity
C5746_RS41640	COG0494	nUDIX hydrolase
C5746_RS41670	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS41705	COG1414	Transcriptional regulator
C5746_RS41715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5746_RS41720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5746_RS41730	COG3485	protocatechuate 3,4-dioxygenase
C5746_RS41735	COG0183	Belongs to the thiolase family
C5746_RS41755	COG0598	Magnesium transport protein CorA
C5746_RS41825	COG0640	Transcriptional regulator
C5746_RS41870	COG0477	Major facilitator Superfamily
C5746_RS41880	COG4941	Belongs to the sigma-70 factor family
C5746_RS41900	COG0604	alcohol dehydrogenase
C5746_RS41900	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS41900	COG3321	synthase
C5746_RS41905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5746_RS41930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5746_RS42000	COG0789	Transcriptional regulator
C5746_RS42085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5746_RS42100	COG0443	Heat shock 70 kDa protein
C5746_RS42105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5746_RS42115	COG0726	polysaccharide deacetylase
C5746_RS42125	COG0300	oxidoreductase activity
C5746_RS42130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5746_RS42185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5746_RS42200	COG0395	ABC-type sugar transport system, permease component
C5746_RS42255	COG2801	Transposase and inactivated derivatives
C5746_RS42260	COG2826	transposase and inactivated derivatives, IS30 family
C5746_RS42310	COG2197	response regulator
C5746_RS42330	COG2197	response regulator
C5746_RS42335	COG3851	Histidine kinase
C5746_RS42340	COG1131	(ABC) transporter
C5746_RS42355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5746_RS42410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5746_RS42425	COG1132	(ABC) transporter
C5746_RS42480	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS42495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5746_RS42500	COG0656	L-ascorbic acid biosynthetic process
C5746_RS42515	COG2814	Major facilitator Superfamily
C5746_RS42550	COG0596	Alpha beta hydrolase
C5746_RS42550	COG2945	thiolester hydrolase activity
C5746_RS42595	COG1309	transcriptional regulator
C5746_RS42600	COG1028	Short-chain dehydrogenase reductase Sdr
C5746_RS42685	COG2130	NADP-dependent
C5746_RS42705	COG1051	belongs to the nudix hydrolase family
C5746_RS42830	COG2197	response regulator
C5746_RS42835	COG4585	Histidine kinase
C5746_RS42840	COG2409	Drug exporters of the RND superfamily
C5746_RS42850	COG3547	Transposase (IS116 IS110 IS902 family)
C5746_RS42875	COG0154	amidase activity
C5746_RS42905	COG0488	(ABC) transporter
C5746_RS42910	COG0488	(ABC) transporter
C5746_RS43025	COG1609	Transcriptional regulator
C5746_RS43035	COG0395	ABC-type sugar transport system, permease component
C5746_RS43060	COG4733	cellulase activity
C5746_RS43060	COG5297	Belongs to the glycosyl hydrolase family 6
C5746_RS43090	COG2755	lipolytic protein G-D-S-L family
C5746_RS43130	COG0789	Transcriptional regulator
C5746_RS43155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5746_RS43315	COG3655	Transcriptional regulator