locus-tag	class	description
B6264_RS00055	COG1846	Transcriptional regulator
B6264_RS00090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6264_RS00095	COG0438	transferase activity, transferring glycosyl groups
B6264_RS00130	COG1940	carbohydrate kinase activity
B6264_RS00150	COG3835	regulator
B6264_RS00160	COG0110	maltose O-acetyltransferase activity
B6264_RS00200	COG0445	tRNA wobble uridine modification
B6264_RS00225	COG0791	NLP P60 protein
B6264_RS00225	COG3883	PFAM NLP P60 protein
B6264_RS00230	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS00235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6264_RS00285	COG4221	oxidoreductase activity
B6264_RS00295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6264_RS00300	COG0765	amino acid transport
B6264_RS00330	COG1309	transcriptional regulator
B6264_RS00365	COG0366	Alpha amylase catalytic
B6264_RS00370	COG3833	ABC-type maltose transport systems, permease component
B6264_RS00380	COG2182	Extracellular solute-binding protein
B6264_RS00400	COG2124	cytochrome p450
B6264_RS00405	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS00415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6264_RS00420	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6264_RS00445	COG2855	membrane
B6264_RS00455	COG0583	DNA-binding transcription factor activity
B6264_RS00460	COG0765	amino acid transport
B6264_RS00465	COG0765	amino acid transport
B6264_RS00475	COG1126	abc transporter atp-binding protein
B6264_RS00485	COG1132	(ABC) transporter
B6264_RS00495	COG0656	L-ascorbic acid biosynthetic process
B6264_RS00510	COG0671	phosphoesterase, PA-phosphatase related
B6264_RS00545	COG1657	PFAM Prenyltransferase squalene oxidase
B6264_RS00555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6264_RS00565	COG1562	ergosterol biosynthetic process
B6264_RS00570	COG1134	teichoic acid transport
B6264_RS00590	COG0371	Dehydrogenase
B6264_RS00595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6264_RS00600	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6264_RS00615	COG0531	amino acid
B6264_RS00635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6264_RS00650	COG0697	spore germination
B6264_RS00685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6264_RS00720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6264_RS00735	COG2207	Transcriptional regulator
B6264_RS00735	COG3708	Transcriptional regulator
B6264_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6264_RS00745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6264_RS00755	COG5001	Diguanylate cyclase
B6264_RS00775	COG3572	ergothioneine biosynthetic process
B6264_RS00780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6264_RS00785	COG0121	glutamine amidotransferase
B6264_RS00790	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B6264_RS00795	COG0477	Major facilitator Superfamily
B6264_RS00800	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B6264_RS00810	COG1960	acyl-CoA dehydrogenase activity
B6264_RS00815	COG0183	Belongs to the thiolase family
B6264_RS00880	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B6264_RS00925	COG1946	Acyl-CoA thioesterase
B6264_RS00930	COG1309	transcriptional regulator
B6264_RS00935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6264_RS00970	COG0708	Exodeoxyribonuclease III
B6264_RS00975	COG0405	Gamma-glutamyltransferase
B6264_RS00985	COG1940	carbohydrate kinase activity
B6264_RS01010	COG3835	regulator
B6264_RS01030	COG2252	PERMEase
B6264_RS01040	COG1280	lysine exporter protein (LysE YggA)
B6264_RS01070	COG0753	catalase activity
B6264_RS01075	COG4266	Belongs to the allantoicase family
B6264_RS01080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6264_RS01085	COG1929	Belongs to the glycerate kinase type-1 family
B6264_RS01090	COG2084	Dehydrogenase
B6264_RS01095	COG3622	Belongs to the hyi family
B6264_RS01115	COG2351	hydroxyisourate hydrolase activity
B6264_RS01140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6264_RS01145	COG1414	Transcriptional regulator
B6264_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS01195	COG0667	Aldo Keto reductase
B6264_RS01200	COG0745	RESPONSE REGULATOR receiver
B6264_RS01215	COG2018	Roadblock/LC7 domain
B6264_RS01220	COG0642	Histidine kinase
B6264_RS01250	COG0748	coenzyme F420 binding
B6264_RS01255	COG2755	lipolytic protein G-D-S-L family
B6264_RS01260	COG2755	lipolytic protein G-D-S-L family
B6264_RS01270	COG0420	3'-5' exonuclease activity
B6264_RS01275	COG0419	ATPase involved in DNA repair
B6264_RS01300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6264_RS01315	COG1132	(ABC) transporter
B6264_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS01365	COG2072	flavoprotein involved in K transport
B6264_RS01375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6264_RS01385	COG1733	regulation of RNA biosynthetic process
B6264_RS01400	COG0515	serine threonine protein kinase
B6264_RS01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS01430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS01435	COG1120	ATPase activity
B6264_RS01440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6264_RS01455	COG2814	Major facilitator Superfamily
B6264_RS01460	COG4264	IucA IucC family
B6264_RS01470	COG0483	inositol monophosphate 1-phosphatase activity
B6264_RS01485	COG4565	transcriptional regulatory protein
B6264_RS01490	COG3290	protein histidine kinase activity
B6264_RS01495	COG1301	dicarboxylic acid transport
B6264_RS01525	COG2018	Roadblock/LC7 domain
B6264_RS01535	COG5001	Diguanylate cyclase
B6264_RS01535	COG3300	MHYT domain
B6264_RS01540	COG2124	cytochrome p450
B6264_RS01550	COG0725	ABC transporter, periplasmic molybdate-binding protein
B6264_RS01565	COG2197	response regulator
B6264_RS01570	COG4585	Histidine kinase
B6264_RS01575	COG1131	(ABC) transporter
B6264_RS01605	COG0393	Putative heavy-metal-binding
B6264_RS01610	COG2072	flavoprotein involved in K transport
B6264_RS01615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6264_RS01620	COG2151	metal-sulfur cluster biosynthetic enzyme
B6264_RS01625	COG3396	Phenylacetate-CoA oxygenase
B6264_RS01630	COG3460	Phenylacetate-CoA oxygenase
B6264_RS01635	COG3396	Phenylacetate-CoA oxygenase
B6264_RS01645	COG2197	response regulator
B6264_RS01660	COG0667	Aldo Keto reductase
B6264_RS01665	COG1309	transcriptional regulator
B6264_RS01680	COG1953	Uracil, thiamine, allantoin
B6264_RS01690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6264_RS01720	COG1125	glycine betaine transport
B6264_RS01720	COG0517	IMP dehydrogenase activity
B6264_RS01725	COG1174	glycine betaine transport
B6264_RS01730	COG1174	glycine betaine transport
B6264_RS01750	COG3979	chitinase
B6264_RS01755	COG2814	Major facilitator Superfamily
B6264_RS01780	COG1960	acyl-CoA dehydrogenase activity
B6264_RS01805	COG1396	sequence-specific DNA binding
B6264_RS01820	COG0114	fumarate hydratase activity
B6264_RS01845	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B6264_RS01865	COG1024	Enoyl-CoA hydratase
B6264_RS01940	COG1120	ATPase activity
B6264_RS01970	COG1960	acyl-CoA dehydrogenase activity
B6264_RS01995	COG1846	Transcriptional regulator
B6264_RS02005	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B6264_RS02010	COG0714	Associated with various cellular activities
B6264_RS02050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6264_RS02055	COG2843	Capsule synthesis protein
B6264_RS02065	COG0501	Belongs to the peptidase M48B family
B6264_RS02105	COG2197	response regulator
B6264_RS02115	COG0829	nickel cation binding
B6264_RS02120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B6264_RS02125	COG0830	nickel cation binding
B6264_RS02130	COG0804	urea catabolic process
B6264_RS02145	COG0831	urea catabolic process
B6264_RS02160	COG2267	carboxylic ester hydrolase activity
B6264_RS02190	COG0583	DNA-binding transcription factor activity
B6264_RS02200	COG0667	Aldo Keto reductase
B6264_RS02225	COG3409	Peptidoglycan-binding domain 1 protein
B6264_RS02235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6264_RS02240	COG2186	Transcriptional regulator
B6264_RS02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS02350	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6264_RS02350	COG1902	pentaerythritol trinitrate reductase activity
B6264_RS02380	COG0477	Major facilitator Superfamily
B6264_RS02395	COG0277	FAD linked oxidase domain protein
B6264_RS02455	COG0477	Major facilitator Superfamily
B6264_RS02465	COG3469	chitinase activity
B6264_RS02505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6264_RS02510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6264_RS02535	COG2197	response regulator
B6264_RS02540	COG4585	Histidine kinase
B6264_RS02595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6264_RS02600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6264_RS02605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6264_RS02610	COG0254	rRNA binding
B6264_RS02620	COG0667	Aldo Keto reductase
B6264_RS02645	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B6264_RS02650	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B6264_RS02655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B6264_RS02665	COG0531	amino acid
B6264_RS02725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6264_RS02730	COG0667	Aldo Keto reductase
B6264_RS02740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS02775	COG0667	Aldo Keto reductase
B6264_RS02820	COG1652	LysM domain
B6264_RS02855	COG1609	Transcriptional regulator
B6264_RS02890	COG0443	Heat shock 70 kDa protein
B6264_RS02900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6264_RS02930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6264_RS02935	COG1121	(ABC) transporter
B6264_RS02965	COG0523	cobalamin synthesis protein
B6264_RS02970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6264_RS02980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6264_RS02985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6264_RS02990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6264_RS02995	COG0254	rRNA binding
B6264_RS03010	COG0701	Predicted permease
B6264_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS03060	COG1120	ATPase activity
B6264_RS03070	COG2124	cytochrome p450
B6264_RS03075	COG0367	asparagine synthase
B6264_RS03125	COG3547	Transposase (IS116 IS110 IS902 family)
B6264_RS03135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B6264_RS03160	COG2814	Major facilitator Superfamily
B6264_RS03165	COG4702	Belongs to the UPF0303 family
B6264_RS03185	COG1609	Transcriptional regulator
B6264_RS03195	COG0395	ABC-type sugar transport system, permease component
B6264_RS03210	COG1349	DNA-binding transcription factor activity
B6264_RS03215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6264_RS03235	COG0582	viral genome integration into host DNA
B6264_RS03240	COG2318	DinB family
B6264_RS03390	COG2801	Transposase and inactivated derivatives
B6264_RS03395	COG2826	transposase and inactivated derivatives, IS30 family
B6264_RS03400	COG2801	Transposase and inactivated derivatives
B6264_RS03415	COG0539	negative regulation of cytoplasmic translation
B6264_RS03440	COG2801	Transposase and inactivated derivatives
B6264_RS03445	COG3328	transposase activity
B6264_RS03455	COG3209	COG3209 Rhs family protein
B6264_RS03470	COG0477	Major facilitator Superfamily
B6264_RS03480	COG1946	Acyl-CoA thioesterase
B6264_RS03495	COG1652	LysM domain
B6264_RS03515	COG1160	GTP binding
B6264_RS03520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6264_RS03555	COG1187	pseudouridine synthase activity
B6264_RS03560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6264_RS03565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6264_RS03580	COG0686	Belongs to the AlaDH PNT family
B6264_RS03585	COG3629	intracellular signal transduction
B6264_RS03585	COG3903	Transcriptional regulator
B6264_RS03590	COG0494	nUDIX hydrolase
B6264_RS03595	COG0504	CTP synthase activity
B6264_RS03600	COG3387	PFAM Glycoside hydrolase 15-related
B6264_RS03610	COG0497	DNA recombination
B6264_RS03620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6264_RS03625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6264_RS03650	COG0647	UMP catabolic process
B6264_RS03695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6264_RS03710	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6264_RS03735	COG1119	ATPase activity
B6264_RS03745	COG2197	response regulator
B6264_RS03750	COG4585	Histidine kinase
B6264_RS03755	COG1716	ATPase activity
B6264_RS03755	COG1131	(ABC) transporter
B6264_RS03755	COG0842	Transport permease protein
B6264_RS03760	COG3830	Belongs to the UPF0237 family
B6264_RS03760	COG0560	Phosphoserine phosphatase
B6264_RS03770	COG2807	transmembrane transport
B6264_RS03775	COG2186	Transcriptional regulator
B6264_RS03780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6264_RS03805	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B6264_RS03820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6264_RS03825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6264_RS03835	COG1063	alcohol dehydrogenase
B6264_RS03840	COG2176	DNA-directed DNA polymerase activity
B6264_RS03855	COG0789	Transcriptional regulator
B6264_RS03900	COG0488	(ABC) transporter
B6264_RS03935	COG0728	peptidoglycan biosynthetic process
B6264_RS03945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6264_RS03975	COG0174	glutamine synthetase
B6264_RS03995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS03995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS04000	COG2301	Belongs to the HpcH HpaI aldolase family
B6264_RS04010	COG1960	acyl-CoA dehydrogenase activity
B6264_RS04015	COG0688	phosphatidylethanolamine metabolic process
B6264_RS04045	COG1492	cobalamin metabolic process
B6264_RS04060	COG1797	cobyrinic acid a,c-diamide synthase activity
B6264_RS04065	COG3896	Chloramphenicol phosphotransferase-like protein
B6264_RS04085	COG2226	methyltransferase
B6264_RS04095	COG0697	spore germination
B6264_RS04115	COG3511	phospholipase C
B6264_RS04155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6264_RS04165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B6264_RS04170	COG0531	amino acid
B6264_RS04180	COG2175	clavaminate synthase activity
B6264_RS04185	COG2188	Transcriptional regulator
B6264_RS04195	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6264_RS04205	COG3842	ATPase activity
B6264_RS04210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6264_RS04280	COG0586	Pfam SNARE associated Golgi protein
B6264_RS04325	COG0473	3-isopropylmalate dehydrogenase activity
B6264_RS04325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6264_RS04340	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS04385	COG0822	iron-sulfur transferase activity
B6264_RS04390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6264_RS04395	COG0396	ATPase activity
B6264_RS04435	COG1612	heme a metabolic process
B6264_RS04485	COG0109	protoheme IX farnesyltransferase activity
B6264_RS04490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B6264_RS04495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6264_RS04510	COG0363	glucosamine-6-phosphate deaminase activity
B6264_RS04520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6264_RS04525	COG0149	triose-phosphate isomerase activity
B6264_RS04530	COG0126	phosphoglycerate kinase activity
B6264_RS04535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B6264_RS04540	COG1481	regulation of sporulation
B6264_RS04550	COG1660	Displays ATPase and GTPase activities
B6264_RS04555	COG0322	excinuclease ABC activity
B6264_RS04565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6264_RS04575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6264_RS04590	COG0556	nucleotide-excision repair
B6264_RS04610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6264_RS04615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6264_RS04675	COG3253	May function as heme-dependent peroxidase
B6264_RS04680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6264_RS04690	COG1683	Conserved Protein
B6264_RS04700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B6264_RS04720	COG0183	Belongs to the thiolase family
B6264_RS04725	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6264_RS04725	COG1024	Enoyl-CoA hydratase
B6264_RS04740	COG1940	carbohydrate kinase activity
B6264_RS04780	COG0668	transmembrane transport
B6264_RS04795	COG1175	transmembrane transport
B6264_RS04800	COG0395	ABC-type sugar transport system, permease component
B6264_RS04805	COG1486	melibiose metabolic process
B6264_RS04830	COG4585	Histidine kinase
B6264_RS04835	COG1131	(ABC) transporter
B6264_RS04850	COG2188	Transcriptional regulator
B6264_RS04870	COG2255	four-way junction helicase activity
B6264_RS04875	COG0577	efflux transmembrane transporter activity
B6264_RS04875	COG1136	(ABC) transporter
B6264_RS04910	COG0154	amidase activity
B6264_RS04925	COG1834	amidinotransferase
B6264_RS04955	COG1136	(ABC) transporter
B6264_RS04955	COG0577	efflux transmembrane transporter activity
B6264_RS04965	COG2197	response regulator
B6264_RS04980	COG0473	3-isopropylmalate dehydrogenase activity
B6264_RS04990	COG0066	3-isopropylmalate dehydratase activity
B6264_RS04995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6264_RS05000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6264_RS05020	COG0583	DNA-binding transcription factor activity
B6264_RS05025	COG1278	Cold shock
B6264_RS05030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6264_RS05030	COG0515	serine threonine protein kinase
B6264_RS05040	COG0583	DNA-binding transcription factor activity
B6264_RS05050	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS05070	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS05080	COG4977	sequence-specific DNA binding
B6264_RS05085	COG1335	isochorismatase
B6264_RS05095	COG1595	DNA-templated transcription, initiation
B6264_RS05100	COG2318	DinB family
B6264_RS05115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6264_RS05185	COG0629	single-stranded DNA binding
B6264_RS05200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6264_RS05205	COG0477	Major facilitator Superfamily
B6264_RS05215	COG1024	Enoyl-CoA hydratase
B6264_RS05225	COG1960	acyl-CoA dehydrogenase activity
B6264_RS05240	COG0339	signal peptide processing
B6264_RS05245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6264_RS05245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6264_RS05255	COG2376	Dihydroxyacetone kinase
B6264_RS05260	COG1461	Dihydroxyacetone kinase
B6264_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS05290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6264_RS05330	COG0756	dUTP diphosphatase activity
B6264_RS05355	COG2205	protein histidine kinase activity
B6264_RS05360	COG0745	RESPONSE REGULATOR receiver
B6264_RS05375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B6264_RS05410	COG1435	thymidine kinase activity
B6264_RS05430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6264_RS05435	COG1690	Belongs to the RtcB family
B6264_RS05445	COG0612	Peptidase, M16
B6264_RS05450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6264_RS05465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6264_RS05475	COG3290	protein histidine kinase activity
B6264_RS05480	COG4565	transcriptional regulatory protein
B6264_RS05485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6264_RS05495	COG2197	response regulator
B6264_RS05500	COG4585	Histidine kinase
B6264_RS05510	COG0187	DNA topoisomerase II activity
B6264_RS05525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6264_RS05530	COG2186	Transcriptional regulator
B6264_RS05570	COG0514	ATP-dependent DNA helicase (RecQ)
B6264_RS05585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6264_RS05605	COG0395	ABC-type sugar transport system, permease component
B6264_RS05610	COG1175	transmembrane transport
B6264_RS05615	COG1653	transport
B6264_RS05650	COG0542	response to heat
B6264_RS05660	COG0702	epimerase
B6264_RS05665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6264_RS05670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6264_RS05675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6264_RS05715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6264_RS05720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6264_RS05725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6264_RS05735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6264_RS05750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6264_RS05755	COG2358	TRAP transporter, solute receptor (TAXI family
B6264_RS05760	COG2205	protein histidine kinase activity
B6264_RS05765	COG0745	RESPONSE REGULATOR receiver
B6264_RS05770	COG1126	abc transporter atp-binding protein
B6264_RS05780	COG0765	amino acid transport
B6264_RS05785	COG0765	amino acid transport
B6264_RS05790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS05815	COG1404	Belongs to the peptidase S8 family
B6264_RS05820	COG1201	RNA secondary structure unwinding
B6264_RS05835	COG1546	Belongs to the CinA family
B6264_RS05835	COG1058	Belongs to the CinA family
B6264_RS05845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6264_RS05855	COG1674	ftsk spoiiie
B6264_RS05865	COG2205	protein histidine kinase activity
B6264_RS05865	COG0784	Response regulator, receiver
B6264_RS05920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6264_RS05925	COG1177	transmembrane transport
B6264_RS05930	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6264_RS05935	COG3842	ATPase activity
B6264_RS05940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6264_RS05960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B6264_RS05965	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS05975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6264_RS05980	COG1136	(ABC) transporter
B6264_RS05990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6264_RS05995	COG0575	Belongs to the CDS family
B6264_RS06000	COG0233	cytoplasmic translational termination
B6264_RS06005	COG0528	UMP kinase activity
B6264_RS06010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6264_RS06015	COG0052	Belongs to the universal ribosomal protein uS2 family
B6264_RS06030	COG1191	sigma factor activity
B6264_RS06045	COG0792	nuclease activity
B6264_RS06055	COG0494	nUDIX hydrolase
B6264_RS06065	COG0681	Belongs to the peptidase S26 family
B6264_RS06070	COG0681	Belongs to the peptidase S26 family
B6264_RS06080	COG0335	large ribosomal subunit rRNA binding
B6264_RS06085	COG0336	Belongs to the RNA methyltransferase TrmD family
B6264_RS06090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6264_RS06095	COG1837	Belongs to the UPF0109 family
B6264_RS06100	COG0228	four-way junction DNA binding
B6264_RS06110	COG0442	prolyl-tRNA aminoacylation
B6264_RS06120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6264_RS06135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B6264_RS06175	COG1254	Belongs to the acylphosphatase family
B6264_RS06190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6264_RS06195	COG0571	ribonuclease III activity
B6264_RS06200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6264_RS06215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6264_RS06220	COG0742	ribosomal rna small subunit methyltransferase
B6264_RS06235	COG1461	Dihydroxyacetone kinase
B6264_RS06240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6264_RS06245	COG0351	phosphomethylpyrimidine kinase
B6264_RS06250	COG0205	6-phosphofructokinase activity
B6264_RS06270	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6264_RS06275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6264_RS06285	COG1920	GTP binding
B6264_RS06295	COG0776	regulation of translation
B6264_RS06305	COG0066	3-isopropylmalate dehydratase activity
B6264_RS06310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6264_RS06315	COG1414	Transcriptional regulator
B6264_RS06345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6264_RS06350	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6264_RS06365	COG2018	Roadblock/LC7 domain
B6264_RS06385	COG2018	Roadblock/LC7 domain
B6264_RS06400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6264_RS06405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6264_RS06410	COG0473	3-isopropylmalate dehydrogenase activity
B6264_RS06425	COG1404	Belongs to the peptidase S8 family
B6264_RS06440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6264_RS06445	COG0440	acetolactate synthase activity
B6264_RS06455	COG5001	Diguanylate cyclase
B6264_RS06460	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B6264_RS06460	COG1672	PFAM Archaeal ATPase
B6264_RS06465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6264_RS06475	COG0154	amidase activity
B6264_RS06480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6264_RS06490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6264_RS06505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6264_RS06545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6264_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS06570	COG0482	sulfurtransferase activity
B6264_RS06585	COG2860	membrane
B6264_RS06590	COG4608	Belongs to the ABC transporter superfamily
B6264_RS06600	COG0601	transmembrane transport
B6264_RS06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6264_RS06625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6264_RS06630	COG0509	glycine decarboxylation via glycine cleavage system
B6264_RS06635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6264_RS06640	COG1760	l-serine dehydratase
B6264_RS06645	COG0477	Major facilitator Superfamily
B6264_RS06675	COG0697	spore germination
B6264_RS06720	COG1376	ErfK ybiS ycfS ynhG family protein
B6264_RS06730	COG1132	(ABC) transporter
B6264_RS06735	COG1132	(ABC) transporter
B6264_RS06740	COG0058	SHG alpha-glucan phosphorylase activity
B6264_RS06745	COG0366	Alpha amylase catalytic
B6264_RS06750	COG0366	Alpha amylase catalytic
B6264_RS06760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6264_RS06765	COG0857	belongs to the CobB CobQ family
B6264_RS06765	COG0280	phosphate acetyltransferase
B6264_RS06770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6264_RS06805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS06805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS06815	COG1846	Transcriptional regulator
B6264_RS06860	COG0183	Belongs to the thiolase family
B6264_RS06865	COG0346	lactoylglutathione lyase activity
B6264_RS06885	COG2267	carboxylic ester hydrolase activity
B6264_RS06915	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B6264_RS06930	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6264_RS06935	COG2197	response regulator
B6264_RS06940	COG4585	Histidine kinase
B6264_RS06960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6264_RS06965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6264_RS06970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6264_RS06975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6264_RS06980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6264_RS06985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6264_RS06990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6264_RS07010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6264_RS07015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6264_RS07025	COG2890	protein-(glutamine-N5) methyltransferase activity
B6264_RS07030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6264_RS07035	COG0254	rRNA binding
B6264_RS07040	COG1316	TRANSCRIPTIONal
B6264_RS07050	COG0083	homoserine kinase activity
B6264_RS07055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6264_RS07060	COG0460	homoserine dehydrogenase
B6264_RS07065	COG0019	diaminopimelate decarboxylase activity
B6264_RS07070	COG0018	arginyl-trna synthetase
B6264_RS07075	COG0745	RESPONSE REGULATOR receiver
B6264_RS07090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6264_RS07105	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6264_RS07110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6264_RS07115	COG2815	serine threonine protein kinase
B6264_RS07115	COG0515	serine threonine protein kinase
B6264_RS07120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6264_RS07125	COG1126	abc transporter atp-binding protein
B6264_RS07150	COG0765	amino acid transport
B6264_RS07160	COG0515	serine threonine protein kinase
B6264_RS07160	COG2815	serine threonine protein kinase
B6264_RS07185	COG0477	Major facilitator Superfamily
B6264_RS07210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6264_RS07220	COG0745	RESPONSE REGULATOR receiver
B6264_RS07225	COG2205	protein histidine kinase activity
B6264_RS07230	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6264_RS07230	COG0567	Dehydrogenase, E1 component
B6264_RS07255	COG0604	alcohol dehydrogenase
B6264_RS07260	COG0281	malic enzyme
B6264_RS07265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6264_RS07275	COG0765	amino acid transport
B6264_RS07300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS07305	COG1120	ATPase activity
B6264_RS07325	COG2172	sigma factor antagonist activity
B6264_RS07340	COG1597	lipid kinase activity
B6264_RS07355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6264_RS07365	COG1472	Belongs to the glycosyl hydrolase 3 family
B6264_RS07370	COG0395	ABC-type sugar transport system, permease component
B6264_RS07375	COG1175	transmembrane transport
B6264_RS07380	COG2182	Extracellular solute-binding protein
B6264_RS07385	COG2188	Transcriptional regulator
B6264_RS07415	COG2755	lipolytic protein G-D-S-L family
B6264_RS07415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6264_RS07450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6264_RS07475	COG0242	peptide deformylase activity
B6264_RS07490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B6264_RS07490	COG2199	diguanylate cyclase activity
B6264_RS07495	COG5662	AntiSigma factor
B6264_RS07500	COG1595	DNA-templated transcription, initiation
B6264_RS07510	COG2135	peptidase activity
B6264_RS07520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6264_RS07535	COG0483	inositol monophosphate 1-phosphatase activity
B6264_RS07540	COG0753	catalase activity
B6264_RS07565	COG1615	UPF0182 protein
B6264_RS07575	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6264_RS07620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6264_RS07650	COG2188	Transcriptional regulator
B6264_RS07675	COG1136	(ABC) transporter
B6264_RS07675	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6264_RS07700	COG0210	DNA helicase
B6264_RS07735	COG0596	Alpha beta hydrolase
B6264_RS07760	COG0513	Belongs to the DEAD box helicase family
B6264_RS07765	COG0596	Alpha beta hydrolase
B6264_RS07775	COG0613	PHP domain protein
B6264_RS07785	COG0598	Magnesium transport protein CorA
B6264_RS07800	COG2239	Acts as a magnesium transporter
B6264_RS07820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6264_RS07830	COG1595	DNA-templated transcription, initiation
B6264_RS07845	COG1024	Enoyl-CoA hydratase
B6264_RS07850	COG0519	Catalyzes the synthesis of GMP from XMP
B6264_RS07860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B6264_RS07865	COG1611	Belongs to the LOG family
B6264_RS07870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6264_RS07905	COG2197	response regulator
B6264_RS07915	COG4585	Histidine kinase
B6264_RS07925	COG1131	(ABC) transporter
B6264_RS07940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B6264_RS07960	COG0444	Belongs to the ABC transporter superfamily
B6264_RS07965	COG4608	Belongs to the ABC transporter superfamily
B6264_RS07975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6264_RS07990	COG4608	Belongs to the ABC transporter superfamily
B6264_RS07995	COG0444	Belongs to the ABC transporter superfamily
B6264_RS08000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6264_RS08005	COG0601	transmembrane transport
B6264_RS08015	COG1217	gtp-binding protein TYPA
B6264_RS08055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6264_RS08055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6264_RS08070	COG0012	GTP binding
B6264_RS08090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6264_RS08100	COG1570	exodeoxyribonuclease VII activity
B6264_RS08110	COG1722	exodeoxyribonuclease VII activity
B6264_RS08115	COG0778	Nitroreductase
B6264_RS08145	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B6264_RS08145	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B6264_RS08155	COG2188	Transcriptional regulator
B6264_RS08165	COG3903	Transcriptional regulator
B6264_RS08165	COG3629	intracellular signal transduction
B6264_RS08180	COG2409	Drug exporters of the RND superfamily
B6264_RS08195	COG0450	alkyl hydroperoxide reductase
B6264_RS08200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6264_RS08225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B6264_RS08230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6264_RS08245	COG0436	Aminotransferase
B6264_RS08250	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B6264_RS08265	COG0477	Major facilitator Superfamily
B6264_RS08270	COG1309	transcriptional regulator
B6264_RS08310	COG1331	Highly conserved protein containing a thioredoxin domain
B6264_RS08320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B6264_RS08330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6264_RS08345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6264_RS08360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6264_RS08370	COG1595	DNA-templated transcription, initiation
B6264_RS08395	COG0183	Belongs to the thiolase family
B6264_RS08420	COG1136	(ABC) transporter
B6264_RS08425	COG0577	efflux transmembrane transporter activity
B6264_RS08430	COG1252	NADH dehydrogenase
B6264_RS08450	COG0148	phosphopyruvate hydratase activity
B6264_RS08455	COG1652	LysM domain
B6264_RS08460	COG2124	cytochrome p450
B6264_RS08515	COG4585	Histidine kinase
B6264_RS08520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B6264_RS08530	COG1595	DNA-templated transcription, initiation
B6264_RS08540	COG0193	aminoacyl-tRNA hydrolase activity
B6264_RS08545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6264_RS08550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6264_RS08555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6264_RS08570	COG1309	transcriptional regulator
B6264_RS08575	COG4106	trans-aconitate 2-methyltransferase activity
B6264_RS08585	COG2197	response regulator
B6264_RS08600	COG2204	response regulator
B6264_RS08610	COG1733	regulation of RNA biosynthetic process
B6264_RS08615	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6264_RS08620	COG0477	Major facilitator Superfamily
B6264_RS08625	COG4935	Belongs to the peptidase S8 family
B6264_RS08625	COG1404	Belongs to the peptidase S8 family
B6264_RS08655	COG0488	(ABC) transporter
B6264_RS08660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6264_RS08665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6264_RS08670	COG0084	hydrolase, TatD family'
B6264_RS08675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6264_RS08695	COG0768	penicillin binding
B6264_RS08705	COG0531	amino acid
B6264_RS08710	COG0768	penicillin binding
B6264_RS08715	COG0772	Belongs to the SEDS family
B6264_RS08725	COG1121	(ABC) transporter
B6264_RS08750	COG5650	phosphatidylinositol metabolic process
B6264_RS08765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6264_RS08770	COG0521	Mo-molybdopterin cofactor biosynthetic process
B6264_RS08775	COG0315	cyclic pyranopterin monophosphate synthase activity
B6264_RS08785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6264_RS08790	COG3706	GGDEF domain
B6264_RS08795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6264_RS08800	COG2366	antibiotic biosynthetic process
B6264_RS08805	COG3263	regulation of cellular component size
B6264_RS08820	COG1970	mechanosensitive ion channel activity
B6264_RS08870	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6264_RS08880	COG1131	(ABC) transporter
B6264_RS08895	COG0702	epimerase
B6264_RS08900	COG1733	regulation of RNA biosynthetic process
B6264_RS08950	COG1316	TRANSCRIPTIONal
B6264_RS08960	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6264_RS08965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6264_RS08965	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6264_RS08975	COG0142	geranyltranstransferase activity
B6264_RS08980	COG1007	ATP synthesis coupled electron transport
B6264_RS08990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6264_RS08995	COG0713	ATP synthesis coupled electron transport
B6264_RS09005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS09010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6264_RS09015	COG1034	ATP synthesis coupled electron transport
B6264_RS09020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6264_RS09030	COG0649	NAD binding
B6264_RS09035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS09040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS09050	COG2197	response regulator
B6264_RS09070	COG0110	maltose O-acetyltransferase activity
B6264_RS09095	COG2226	methyltransferase
B6264_RS09110	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6264_RS09120	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B6264_RS09125	COG1278	Cold shock
B6264_RS09130	COG1301	dicarboxylic acid transport
B6264_RS09140	COG1609	Transcriptional regulator
B6264_RS09215	COG4821	SIS domain
B6264_RS09230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6264_RS09235	COG3629	intracellular signal transduction
B6264_RS09235	COG3903	Transcriptional regulator
B6264_RS09250	COG2378	regulation of single-species biofilm formation
B6264_RS09300	COG0641	radical SAM
B6264_RS09345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B6264_RS09360	COG2814	Major facilitator Superfamily
B6264_RS09365	COG1846	Transcriptional regulator
B6264_RS09380	COG1024	Enoyl-CoA hydratase
B6264_RS09380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6264_RS09405	COG2252	PERMEase
B6264_RS09415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6264_RS09430	COG2814	Major facilitator Superfamily
B6264_RS09440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6264_RS09445	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B6264_RS09450	COG1278	Cold shock
B6264_RS09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS09470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6264_RS09475	COG1120	ATPase activity
B6264_RS09480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B6264_RS09500	COG0667	Aldo Keto reductase
B6264_RS09555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6264_RS09565	COG3226	Transcriptional regulator
B6264_RS09595	COG1061	Type III restriction enzyme res subunit
B6264_RS09600	COG3973	AAA domain
B6264_RS09615	COG1695	Transcriptional regulator
B6264_RS09630	COG0459	protein refolding
B6264_RS09635	COG1278	Cold shock
B6264_RS09650	COG0463	Glycosyl transferase, family 2
B6264_RS09685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B6264_RS09705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6264_RS09735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6264_RS09750	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6264_RS09750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6264_RS09765	COG0302	gtp cyclohydrolase
B6264_RS09780	COG0037	tRNA processing
B6264_RS09790	COG2027	D-alanyl-D-alanine carboxypeptidase
B6264_RS09795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6264_RS09800	COG3360	Dodecin
B6264_RS09815	COG1490	D-aminoacyl-tRNA deacylase activity
B6264_RS09820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6264_RS09830	COG3485	protocatechuate 3,4-dioxygenase
B6264_RS09850	COG2897	thiosulfate sulfurtransferase activity
B6264_RS09870	COG0745	RESPONSE REGULATOR receiver
B6264_RS09875	COG1609	Transcriptional regulator
B6264_RS09880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6264_RS09885	COG0745	RESPONSE REGULATOR receiver
B6264_RS09925	COG0739	heme binding
B6264_RS09925	COG0741	lytic transglycosylase activity
B6264_RS09925	COG1196	nuclear chromosome segregation
B6264_RS09930	COG0671	phosphoesterase, PA-phosphatase related
B6264_RS09950	COG1937	Protein conserved in bacteria
B6264_RS09960	COG0306	phosphate transporter
B6264_RS09980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6264_RS10000	COG0456	acetyltransferase
B6264_RS10070	COG0579	oxidoreductase
B6264_RS10075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6264_RS10145	COG0642	Histidine kinase
B6264_RS10165	COG2124	cytochrome p450
B6264_RS10180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6264_RS10195	COG1968	undecaprenyl-diphosphatase activity
B6264_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS10210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6264_RS10225	COG0028	Belongs to the TPP enzyme family
B6264_RS10230	COG1554	hydrolase, family 65, central catalytic
B6264_RS10250	COG1316	TRANSCRIPTIONal
B6264_RS10295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6264_RS10345	COG2124	cytochrome p450
B6264_RS10355	COG1131	(ABC) transporter
B6264_RS10370	COG2226	methyltransferase
B6264_RS10385	COG1309	transcriptional regulator
B6264_RS10390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6264_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS10440	COG0513	Belongs to the DEAD box helicase family
B6264_RS10450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6264_RS10455	COG1993	acr, cog1993
B6264_RS10460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6264_RS10500	COG3693	PFAM glycoside hydrolase, family 10
B6264_RS10515	COG1063	alcohol dehydrogenase
B6264_RS10520	COG0583	DNA-binding transcription factor activity
B6264_RS10535	COG1643	Atp-dependent helicase
B6264_RS10555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6264_RS10565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6264_RS10580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6264_RS10605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6264_RS10610	COG2423	ornithine cyclodeaminase activity
B6264_RS10640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6264_RS10645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6264_RS10650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6264_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6264_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS10680	COG4106	trans-aconitate 2-methyltransferase activity
B6264_RS10700	COG2197	response regulator
B6264_RS10710	COG4106	trans-aconitate 2-methyltransferase activity
B6264_RS10715	COG3634	alkyl hydroperoxide reductase activity
B6264_RS10725	COG0667	Aldo Keto reductase
B6264_RS10745	COG1733	regulation of RNA biosynthetic process
B6264_RS10810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6264_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6264_RS10820	COG1362	aminopeptidase activity
B6264_RS10830	COG1136	(ABC) transporter
B6264_RS10835	COG0577	efflux transmembrane transporter activity
B6264_RS10840	COG1960	acyl-CoA dehydrogenase activity
B6264_RS10865	COG2267	carboxylic ester hydrolase activity
B6264_RS10875	COG0154	amidase activity
B6264_RS10920	COG2372	response to copper ion
B6264_RS10925	COG2837	iron assimilation
B6264_RS10930	COG0077	Prephenate dehydratase
B6264_RS10935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6264_RS10940	COG0561	phosphatase activity
B6264_RS10950	COG2807	transmembrane transport
B6264_RS10960	COG1131	(ABC) transporter
B6264_RS10985	COG0561	phosphatase activity
B6264_RS10995	COG4988	ABC transporter
B6264_RS11000	COG1294	oxidase, subunit
B6264_RS11005	COG1271	oxidase subunit
B6264_RS11020	COG2205	protein histidine kinase activity
B6264_RS11025	COG0745	RESPONSE REGULATOR receiver
B6264_RS11035	COG1595	DNA-templated transcription, initiation
B6264_RS11050	COG0596	Alpha beta hydrolase
B6264_RS11055	COG0789	Transcriptional regulator
B6264_RS11090	COG4591	ABC-type transport system involved in lipoprotein release permease component
B6264_RS11090	COG1136	(ABC) transporter
B6264_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6264_RS11095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6264_RS11100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6264_RS11105	COG1609	Transcriptional regulator
B6264_RS11120	COG0667	Aldo Keto reductase
B6264_RS11125	COG0431	NADPH-dependent FMN reductase
B6264_RS11135	COG0583	DNA-binding transcription factor activity
B6264_RS11140	COG0346	lactoylglutathione lyase activity
B6264_RS11170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B6264_RS11180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6264_RS11185	COG0662	Cupin 2, conserved barrel domain protein
B6264_RS11190	COG1950	PFAM Membrane protein of
B6264_RS11215	COG0022	dehydrogenase e1 component
B6264_RS11225	COG1522	sequence-specific DNA binding
B6264_RS11230	COG1309	transcriptional regulator
B6264_RS11245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS11295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6264_RS11310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6264_RS11310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6264_RS11315	COG2197	response regulator
B6264_RS11330	COG1716	ATPase activity
B6264_RS11335	COG1716	ATPase activity
B6264_RS11350	COG0768	penicillin binding
B6264_RS11355	COG0515	serine threonine protein kinase
B6264_RS11360	COG3764	Sortase (surface protein transpeptidase)
B6264_RS11365	COG3764	Sortase (surface protein transpeptidase)
B6264_RS11390	COG0705	Rhomboid family
B6264_RS11390	COG0457	Tetratricopeptide repeat
B6264_RS11420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6264_RS11430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6264_RS11440	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B6264_RS11445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6264_RS11450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6264_RS11455	COG0592	DNA-directed DNA polymerase activity
B6264_RS11465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6264_RS11470	COG0594	ribonuclease P activity
B6264_RS11475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B6264_RS11480	COG0706	membrane insertase activity
B6264_RS11490	COG0357	Ribosomal RNA small subunit methyltransferase G
B6264_RS11495	COG1192	Involved in chromosome partitioning
B6264_RS11510	COG3118	belongs to the thioredoxin family
B6264_RS11510	COG0492	ferredoxin-NADP+ reductase activity
B6264_RS11515	COG0492	ferredoxin-NADP+ reductase activity
B6264_RS11525	COG1595	DNA-templated transcription, initiation
B6264_RS11530	COG0515	serine threonine protein kinase
B6264_RS11530	COG2815	serine threonine protein kinase
B6264_RS11545	COG0617	tRNA 3'-terminal CCA addition
B6264_RS11600	COG0360	Binds together with S18 to 16S ribosomal RNA
B6264_RS11605	COG0629	single-stranded DNA binding
B6264_RS11610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6264_RS11615	COG0359	binds to the 23S rRNA
B6264_RS11625	COG0305	Participates in initiation and elongation during chromosome replication
B6264_RS11630	COG4552	Acetyltransferase involved in intracellular survival and related
B6264_RS11640	COG1482	cell wall glycoprotein biosynthetic process
B6264_RS11645	COG0463	Glycosyl transferase, family 2
B6264_RS11650	COG1733	regulation of RNA biosynthetic process
B6264_RS11655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B6264_RS11660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6264_RS11675	COG0303	'Molybdopterin
B6264_RS11700	COG0515	serine threonine protein kinase
B6264_RS11725	COG0022	dehydrogenase e1 component
B6264_RS11730	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6264_RS11740	COG3135	benzoate transporter
B6264_RS11785	COG0151	Belongs to the GarS family
B6264_RS11800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6264_RS11805	COG2197	response regulator
B6264_RS11840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6264_RS11845	COG0047	phosphoribosylformylglycinamidine synthase activity
B6264_RS11850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6264_RS11870	COG0191	fructose-bisphosphate aldolase activity
B6264_RS11875	COG0586	Pfam SNARE associated Golgi protein
B6264_RS11880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6264_RS11890	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6264_RS11915	COG0542	response to heat
B6264_RS11955	COG0789	Transcriptional regulator
B6264_RS11960	COG0484	heat shock protein binding
B6264_RS11965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6264_RS11970	COG0443	Heat shock 70 kDa protein
B6264_RS11975	COG2181	nitrate reductase activity
B6264_RS11975	COG0247	lactate metabolic process
B6264_RS11980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6264_RS11990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6264_RS11995	COG0717	Belongs to the dCTP deaminase family
B6264_RS12020	COG2197	response regulator
B6264_RS12040	COG2084	Dehydrogenase
B6264_RS12045	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6264_RS12065	COG0789	Transcriptional regulator
B6264_RS12070	COG4977	sequence-specific DNA binding
B6264_RS12075	COG1595	DNA-templated transcription, initiation
B6264_RS12085	COG0006	proline dipeptidase activity
B6264_RS12100	COG0653	protein targeting
B6264_RS12120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6264_RS12140	COG0277	FAD linked oxidase domain protein
B6264_RS12150	COG0259	pyridoxamine-phosphate oxidase activity
B6264_RS12155	COG5006	permease, DMT superfamily
B6264_RS12160	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS12190	COG0667	Aldo Keto reductase
B6264_RS12215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6264_RS12220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6264_RS12230	COG0438	transferase activity, transferring glycosyl groups
B6264_RS12240	COG2365	Tyrosine phosphatase family
B6264_RS12245	COG1191	sigma factor activity
B6264_RS12250	COG1191	sigma factor activity
B6264_RS12280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6264_RS12305	COG1881	PFAM PEBP family protein
B6264_RS12315	COG0477	Major facilitator Superfamily
B6264_RS12340	COG0640	Transcriptional regulator
B6264_RS12360	COG0477	Major facilitator Superfamily
B6264_RS12405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6264_RS12550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6264_RS12555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6264_RS12575	COG1595	DNA-templated transcription, initiation
B6264_RS12585	COG1566	PFAM secretion protein HlyD family protein
B6264_RS12600	COG0477	Major facilitator Superfamily
B6264_RS12635	COG1408	metallophosphoesterase
B6264_RS12650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6264_RS12660	COG0003	Pfam Anion-transporting ATPase
B6264_RS12680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6264_RS12700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B6264_RS12715	COG1846	Transcriptional regulator
B6264_RS12720	COG2197	response regulator
B6264_RS12750	COG2267	carboxylic ester hydrolase activity
B6264_RS12760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B6264_RS12765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6264_RS12770	COG0659	secondary active sulfate transmembrane transporter activity
B6264_RS12825	COG1111	helicase
B6264_RS12825	COG1205	dead DEAH box helicase
B6264_RS12830	COG1366	Belongs to the anti-sigma-factor antagonist family
B6264_RS12835	COG2172	sigma factor antagonist activity
B6264_RS12855	COG2890	protein-(glutamine-N5) methyltransferase activity
B6264_RS12865	COG1754	DNA topoisomerase type I activity
B6264_RS12865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6264_RS12870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6264_RS12875	COG0470	DNA polymerase III
B6264_RS12925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6264_RS12930	COG2813	Specifically methylates the guanine in position
B6264_RS12935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6264_RS12950	COG4221	oxidoreductase activity
B6264_RS12980	COG0494	nUDIX hydrolase
B6264_RS12990	COG2365	Tyrosine phosphatase family
B6264_RS13010	COG0515	serine threonine protein kinase
B6264_RS13015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6264_RS13020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6264_RS13030	COG2226	methyltransferase
B6264_RS13035	COG0477	Major facilitator Superfamily
B6264_RS13060	COG1309	transcriptional regulator
B6264_RS13070	COG0326	Molecular chaperone. Has ATPase activity
B6264_RS13105	COG1309	transcriptional regulator
B6264_RS13125	COG0583	DNA-binding transcription factor activity
B6264_RS13130	COG2353	YceI-like domain
B6264_RS13135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6264_RS13145	COG1595	DNA-templated transcription, initiation
B6264_RS13150	COG4978	Transcriptional regulator
B6264_RS13150	COG0789	Transcriptional regulator
B6264_RS13175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6264_RS13185	COG0438	transferase activity, transferring glycosyl groups
B6264_RS13195	COG2211	Major facilitator Superfamily
B6264_RS13200	COG0588	phosphoglycerate mutase activity
B6264_RS13205	COG3397	chitin binding
B6264_RS13220	COG5002	protein histidine kinase activity
B6264_RS13225	COG0745	RESPONSE REGULATOR receiver
B6264_RS13240	COG1329	Transcriptional regulator
B6264_RS13245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6264_RS13250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B6264_RS13260	COG0215	cysteine-tRNA ligase activity
B6264_RS13265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6264_RS13275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6264_RS13285	COG3842	ATPase activity
B6264_RS13310	COG2815	serine threonine protein kinase
B6264_RS13310	COG0515	serine threonine protein kinase
B6264_RS13315	COG2205	protein histidine kinase activity
B6264_RS13320	COG0745	RESPONSE REGULATOR receiver
B6264_RS13345	COG1132	(ABC) transporter
B6264_RS13360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6264_RS13365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6264_RS13370	COG0142	geranyltranstransferase activity
B6264_RS13400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B6264_RS13420	COG1309	transcriptional regulator
B6264_RS13425	COG0739	heme binding
B6264_RS13445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B6264_RS13465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B6264_RS13475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6264_RS13480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B6264_RS13485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B6264_RS13495	COG2197	response regulator
B6264_RS13500	COG4585	Histidine kinase
B6264_RS13510	COG0649	NAD binding
B6264_RS13540	COG0584	glycerophosphoryl diester phosphodiesterase
B6264_RS13545	COG0248	Ppx GppA phosphatase
B6264_RS13550	COG1082	Xylose isomerase domain protein TIM barrel
B6264_RS13555	COG2226	methyltransferase
B6264_RS13560	COG0129	dihydroxy-acid dehydratase activity
B6264_RS13580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6264_RS13590	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6264_RS13640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B6264_RS13645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6264_RS13650	COG0181	hydroxymethylbilane synthase activity
B6264_RS13655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6264_RS13655	COG1648	precorrin-2 dehydrogenase activity
B6264_RS13660	COG0113	porphobilinogen synthase activity
B6264_RS13735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6264_RS13740	COG0406	alpha-ribazole phosphatase activity
B6264_RS13745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6264_RS13750	COG0785	Cytochrome C biogenesis protein
B6264_RS13755	COG1333	cytochrome c biogenesis protein
B6264_RS13760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6264_RS13790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6264_RS13800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B6264_RS13805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6264_RS13810	COG0509	glycine decarboxylation via glycine cleavage system
B6264_RS13850	COG0163	prenyltransferase activity
B6264_RS13855	COG1522	sequence-specific DNA binding
B6264_RS13860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6264_RS13865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6264_RS13875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6264_RS13880	COG1309	transcriptional regulator
B6264_RS13885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6264_RS13885	COG0515	serine threonine protein kinase
B6264_RS13890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6264_RS13895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6264_RS13905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS13910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS13915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS13920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6264_RS13925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS13935	COG0713	ATP synthesis coupled electron transport
B6264_RS13945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6264_RS13950	COG1007	ATP synthesis coupled electron transport
B6264_RS13955	COG0501	Belongs to the peptidase M48B family
B6264_RS13965	COG0697	spore germination
B6264_RS13975	COG0501	Belongs to the peptidase M48B family
B6264_RS13980	COG2130	NADP-dependent
B6264_RS13985	COG0583	DNA-binding transcription factor activity
B6264_RS14010	COG1666	GTP binding
B6264_RS14025	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B6264_RS14055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6264_RS14060	COG2030	dehydratase
B6264_RS14075	COG0477	Major facilitator Superfamily
B6264_RS14080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6264_RS14085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6264_RS14090	COG0436	Aminotransferase
B6264_RS14105	COG0250	Participates in transcription elongation, termination and antitermination
B6264_RS14110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6264_RS14115	COG0081	regulation of translation
B6264_RS14140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6264_RS14145	COG0222	ribosome binding
B6264_RS14150	COG0085	RNA polymerase activity
B6264_RS14155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6264_RS14195	COG4585	Histidine kinase
B6264_RS14200	COG2197	response regulator
B6264_RS14220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6264_RS14225	COG2124	cytochrome p450
B6264_RS14245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6264_RS14250	COG1397	ADP-ribosylglycohydrolase
B6264_RS14280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6264_RS14285	COG0049	tRNA binding
B6264_RS14290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6264_RS14295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6264_RS14300	COG0463	Glycosyl transferase, family 2
B6264_RS14340	COG0051	transcription antitermination factor activity, RNA binding
B6264_RS14345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6264_RS14350	COG0088	Forms part of the polypeptide exit tunnel
B6264_RS14360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6264_RS14365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6264_RS14370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6264_RS14375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6264_RS14380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6264_RS14385	COG0255	Belongs to the universal ribosomal protein uL29 family
B6264_RS14390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6264_RS14395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6264_RS14400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6264_RS14405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6264_RS14410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6264_RS14415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6264_RS14420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6264_RS14425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6264_RS14430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6264_RS14435	COG1841	ribosomal large subunit assembly
B6264_RS14440	COG0200	Binds to the 23S rRNA
B6264_RS14450	COG0563	adenylate kinase activity
B6264_RS14465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6264_RS14470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6264_RS14475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6264_RS14480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6264_RS14485	COG0202	RNA polymerase activity
B6264_RS14490	COG0203	ribosomal protein L17
B6264_RS14495	COG0101	tRNA pseudouridine synthase activity
B6264_RS14500	COG0488	(ABC) transporter
B6264_RS14505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6264_RS14510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6264_RS14515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6264_RS14520	COG1072	(Pantothenic acid kinase))
B6264_RS14525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6264_RS14540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6264_RS14550	COG0802	atpase or kinase
B6264_RS14575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6264_RS14585	COG0726	polysaccharide deacetylase
B6264_RS14595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6264_RS14605	COG0583	DNA-binding transcription factor activity
B6264_RS14615	COG2197	response regulator
B6264_RS14620	COG1595	DNA-templated transcription, initiation
B6264_RS14630	COG0516	GMP reductase activity
B6264_RS14655	COG2815	serine threonine protein kinase
B6264_RS14655	COG0515	serine threonine protein kinase
B6264_RS14660	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS14680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6264_RS14680	COG0519	Catalyzes the synthesis of GMP from XMP
B6264_RS14705	COG2197	response regulator
B6264_RS14720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS14720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS14735	COG0714	Associated with various cellular activities
B6264_RS14745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B6264_RS14750	COG0045	succinate-CoA ligase (ADP-forming) activity
B6264_RS14780	COG0138	bifunctional purine biosynthesis protein purh
B6264_RS14790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6264_RS14800	COG0039	L-malate dehydrogenase activity
B6264_RS14805	COG1253	flavin adenine dinucleotide binding
B6264_RS14810	COG0180	Tryptophanyl-tRNA synthetase
B6264_RS14820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6264_RS14825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6264_RS14830	COG1216	Glycosyl transferase, family 2
B6264_RS14835	COG1295	ribonuclease BN
B6264_RS14840	COG1686	Belongs to the peptidase S11 family
B6264_RS14865	COG1053	succinate dehydrogenase
B6264_RS14875	COG2009	succinate dehydrogenase
B6264_RS14895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS14895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6264_RS14900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6264_RS14900	COG1473	amidohydrolase
B6264_RS14905	COG1744	ABC transporter substrate-binding protein PnrA-like
B6264_RS14910	COG3845	ABC transporter
B6264_RS14915	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6264_RS14920	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6264_RS14940	COG2814	Major facilitator Superfamily
B6264_RS14945	COG0583	DNA-binding transcription factor activity
B6264_RS14950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6264_RS14975	COG0384	phenazine biosynthesis protein PhzF
B6264_RS14990	COG2205	protein histidine kinase activity
B6264_RS14995	COG0745	RESPONSE REGULATOR receiver
B6264_RS15000	COG1595	DNA-templated transcription, initiation
B6264_RS15015	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS15020	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS15035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6264_RS15060	COG4770	biotin carboxylase activity
B6264_RS15070	COG0424	maF-like protein
B6264_RS15080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6264_RS15090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B6264_RS15105	COG1309	transcriptional regulator
B6264_RS15115	COG2986	histidine ammonia-lyase
B6264_RS15150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B6264_RS15165	COG1228	amidohydrolase
B6264_RS15230	COG3104	oligopeptide transport
B6264_RS15235	COG0745	RESPONSE REGULATOR receiver
B6264_RS15240	COG2205	protein histidine kinase activity
B6264_RS15270	COG1832	CoA-binding protein
B6264_RS15275	COG1832	CoA-binding protein
B6264_RS15285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6264_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS15325	COG1045	serine acetyltransferase
B6264_RS15330	COG1316	TRANSCRIPTIONal
B6264_RS15335	COG0431	NADPH-dependent FMN reductase
B6264_RS15340	COG0577	efflux transmembrane transporter activity
B6264_RS15340	COG1136	(ABC) transporter
B6264_RS15345	COG0577	efflux transmembrane transporter activity
B6264_RS15355	COG1316	TRANSCRIPTIONal
B6264_RS15360	COG1316	TRANSCRIPTIONal
B6264_RS15380	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B6264_RS15380	COG0778	Nitroreductase
B6264_RS15385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B6264_RS15420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6264_RS15425	COG2835	tetraacyldisaccharide 4'-kinase activity
B6264_RS15440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6264_RS15485	COG3795	YCII-related domain
B6264_RS15490	COG4941	Belongs to the sigma-70 factor family
B6264_RS15500	COG0714	Associated with various cellular activities
B6264_RS15520	COG0745	RESPONSE REGULATOR receiver
B6264_RS15525	COG5000	phosphorelay sensor kinase activity
B6264_RS15525	COG5002	protein histidine kinase activity
B6264_RS15530	COG0823	Involved in the tonB-independent uptake of proteins
B6264_RS15540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6264_RS15545	COG2197	response regulator
B6264_RS15550	COG3214	Protein conserved in bacteria
B6264_RS15560	COG0653	protein targeting
B6264_RS15585	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS15600	COG0515	serine threonine protein kinase
B6264_RS15605	COG0515	serine threonine protein kinase
B6264_RS15610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6264_RS15620	COG2884	Cell division ATP-binding protein ftsE
B6264_RS15630	COG0793	Belongs to the peptidase S41A family
B6264_RS15635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B6264_RS15645	COG3973	AAA domain
B6264_RS15655	COG0776	regulation of translation
B6264_RS15660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6264_RS15675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B6264_RS15685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6264_RS15695	COG2076	Multidrug Resistance protein
B6264_RS15715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B6264_RS15720	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6264_RS15740	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6264_RS15755	COG0745	RESPONSE REGULATOR receiver
B6264_RS15765	COG5650	phosphatidylinositol metabolic process
B6264_RS15790	COG1515	deoxyribonuclease V activity
B6264_RS15850	COG1335	isochorismatase
B6264_RS15860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B6264_RS15870	COG1113	amino acid transport
B6264_RS15900	COG1234	tRNA 3'-trailer cleavage
B6264_RS15910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS15915	COG1263	PTS System
B6264_RS15925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6264_RS15930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6264_RS15940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6264_RS15970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6264_RS15980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6264_RS15995	COG1131	(ABC) transporter
B6264_RS16000	COG1216	Glycosyl transferase, family 2
B6264_RS16005	COG2733	membrane
B6264_RS16010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6264_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS16085	COG1309	transcriptional regulator
B6264_RS16095	COG0702	epimerase
B6264_RS16110	COG0640	Transcriptional regulator
B6264_RS16155	COG0673	inositol 2-dehydrogenase activity
B6264_RS16170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6264_RS16215	COG0559	Belongs to the binding-protein-dependent transport system permease family
B6264_RS16240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS16250	COG1764	response to oxidative stress
B6264_RS16255	COG1605	Chorismate mutase
B6264_RS16255	COG0287	Prephenate dehydrogenase
B6264_RS16260	COG0681	Belongs to the peptidase S26 family
B6264_RS16270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6264_RS16320	COG0583	DNA-binding transcription factor activity
B6264_RS16325	COG5640	endopeptidase activity
B6264_RS16330	COG5640	endopeptidase activity
B6264_RS16340	COG3511	phospholipase C
B6264_RS16355	COG4946	Tricorn protease homolog
B6264_RS16355	COG0793	Belongs to the peptidase S41A family
B6264_RS16365	COG2814	Major facilitator Superfamily
B6264_RS16375	COG4977	sequence-specific DNA binding
B6264_RS16390	COG0025	NhaP-type Na H and K H
B6264_RS16395	COG0166	Belongs to the GPI family
B6264_RS16435	COG0588	phosphoglycerate mutase activity
B6264_RS16475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B6264_RS16480	COG4977	sequence-specific DNA binding
B6264_RS16500	COG1960	acyl-CoA dehydrogenase activity
B6264_RS16515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6264_RS16520	COG1309	transcriptional regulator
B6264_RS16550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6264_RS16555	COG0180	Tryptophanyl-tRNA synthetase
B6264_RS16560	COG1619	proteins homologs of microcin C7 resistance protein MccF
B6264_RS16595	COG2197	response regulator
B6264_RS16610	COG1739	Uncharacterized protein family UPF0029
B6264_RS16630	COG0583	DNA-binding transcription factor activity
B6264_RS16655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B6264_RS16670	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS16675	COG0702	epimerase
B6264_RS16685	COG0750	zinc metalloprotease
B6264_RS16690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B6264_RS16705	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
B6264_RS16715	COG0779	Required for maturation of 30S ribosomal subunits
B6264_RS16730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6264_RS16740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6264_RS16745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6264_RS16750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6264_RS16765	COG0455	bacterial-type flagellum organization
B6264_RS16790	COG4842	Belongs to the WXG100 family
B6264_RS16815	COG1674	ftsk spoiiie
B6264_RS16825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6264_RS16830	COG1185	polyribonucleotide nucleotidyltransferase activity
B6264_RS16835	COG0612	Peptidase, M16
B6264_RS16840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6264_RS16850	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6264_RS16855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6264_RS16860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B6264_RS16910	COG0569	domain protein
B6264_RS16915	COG0531	amino acid
B6264_RS16920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6264_RS16950	COG0189	ligase activity
B6264_RS16980	COG3973	AAA domain
B6264_RS16990	COG2171	N-acyltransferase activity
B6264_RS17000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B6264_RS17005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6264_RS17040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6264_RS17050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B6264_RS17055	COG1113	amino acid transport
B6264_RS17100	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6264_RS17105	COG0740	serine-type endopeptidase activity
B6264_RS17110	COG0740	serine-type endopeptidase activity
B6264_RS17115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6264_RS17130	COG0525	valine-tRNA ligase activity
B6264_RS17150	COG0285	dihydrofolate synthase activity
B6264_RS17160	COG0105	UTP biosynthetic process
B6264_RS17165	COG1077	Cell shape determining protein MreB Mrl
B6264_RS17180	COG0768	penicillin binding
B6264_RS17185	COG0772	Belongs to the SEDS family
B6264_RS17205	COG1530	ribonuclease E activity
B6264_RS17210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6264_RS17215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6264_RS17220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6264_RS17230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6264_RS17240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B6264_RS17255	COG0501	Belongs to the peptidase M48B family
B6264_RS17260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6264_RS17270	COG0799	negative regulation of ribosome biogenesis
B6264_RS17275	COG0406	alpha-ribazole phosphatase activity
B6264_RS17295	COG0477	Major facilitator Superfamily
B6264_RS17310	COG0495	leucyl-tRNA aminoacylation
B6264_RS17320	COG1307	EDD domain protein, DegV family
B6264_RS17325	COG1555	photosystem II stabilization
B6264_RS17340	COG1335	isochorismatase
B6264_RS17370	COG0268	Binds directly to 16S ribosomal RNA
B6264_RS17375	COG2329	Antibiotic biosynthesis monooxygenase
B6264_RS17380	COG0481	GTPase activity
B6264_RS17420	COG0501	Belongs to the peptidase M48B family
B6264_RS17425	COG1420	regulation of RNA biosynthetic process
B6264_RS17430	COG0484	heat shock protein binding
B6264_RS17445	COG0793	Belongs to the peptidase S41A family
B6264_RS17445	COG4946	Tricorn protease homolog
B6264_RS17455	COG0537	adenosine 5'-monophosphoramidase activity
B6264_RS17460	COG1234	tRNA 3'-trailer cleavage
B6264_RS17470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6264_RS17495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6264_RS17510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6264_RS17520	COG1381	Involved in DNA repair and RecF pathway recombination
B6264_RS17525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6264_RS17535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6264_RS17545	COG0423	glycine-tRNA ligase activity
B6264_RS17570	COG2378	regulation of single-species biofilm formation
B6264_RS17605	COG0477	Major facilitator Superfamily
B6264_RS17630	COG2197	response regulator
B6264_RS17645	COG0574	Belongs to the PEP-utilizing enzyme family
B6264_RS17645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6264_RS17650	COG4290	ribonuclease
B6264_RS17685	COG2755	lipolytic protein G-D-S-L family
B6264_RS17690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B6264_RS17695	COG0358	DNA primase activity
B6264_RS17700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6264_RS17710	COG1070	Carbohydrate kinase
B6264_RS17760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B6264_RS17765	COG1316	TRANSCRIPTIONal
B6264_RS17775	COG2130	NADP-dependent
B6264_RS17785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6264_RS17790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6264_RS17795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6264_RS17820	COG0789	Transcriptional regulator
B6264_RS17825	COG0667	Aldo Keto reductase
B6264_RS17835	COG2378	regulation of single-species biofilm formation
B6264_RS17860	COG2197	response regulator
B6264_RS17865	COG4585	Histidine kinase
B6264_RS17870	COG1309	transcriptional regulator
B6264_RS17875	COG0477	Major facilitator Superfamily
B6264_RS17930	COG1358	cellular component organization or biogenesis
B6264_RS18040	COG1595	DNA-templated transcription, initiation
B6264_RS18055	COG0542	response to heat
B6264_RS18060	COG4585	Histidine kinase
B6264_RS18065	COG2197	response regulator
B6264_RS18075	COG1136	(ABC) transporter
B6264_RS18080	COG0577	efflux transmembrane transporter activity
B6264_RS18085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6264_RS18095	COG1309	transcriptional regulator
B6264_RS18115	COG1960	acyl-CoA dehydrogenase activity
B6264_RS18160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6264_RS18170	COG3483	tryptophan 2,3-dioxygenase activity
B6264_RS18175	COG1522	sequence-specific DNA binding
B6264_RS18185	COG2095	MarC family integral membrane protein
B6264_RS18255	COG1472	Belongs to the glycosyl hydrolase 3 family
B6264_RS18265	COG3845	ABC transporter
B6264_RS18285	COG1309	transcriptional regulator
B6264_RS18290	COG0438	transferase activity, transferring glycosyl groups
B6264_RS18310	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6264_RS18330	COG2267	carboxylic ester hydrolase activity
B6264_RS18335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6264_RS18350	COG3022	response to hydroperoxide
B6264_RS18360	COG0557	exoribonuclease II activity
B6264_RS18385	COG1695	Transcriptional regulator
B6264_RS18435	COG1994	Peptidase M50
B6264_RS18455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6264_RS18460	COG0477	Major facilitator Superfamily
B6264_RS18465	COG1309	transcriptional regulator
B6264_RS18480	COG0475	glutathione-regulated potassium exporter activity
B6264_RS18495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6264_RS18505	COG0367	asparagine synthase
B6264_RS18585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B6264_RS18595	COG3629	intracellular signal transduction
B6264_RS18610	COG0174	glutamine synthetase
B6264_RS18615	COG3764	Sortase (surface protein transpeptidase)
B6264_RS18630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6264_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS18735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B6264_RS18740	COG0321	lipoyl(octanoyl) transferase activity
B6264_RS18745	COG2508	Transcriptional regulator
B6264_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS18790	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6264_RS18795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6264_RS18800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6264_RS18805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B6264_RS18810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6264_RS18845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6264_RS18885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6264_RS18895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B6264_RS18900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6264_RS18910	COG1376	ErfK ybiS ycfS ynhG family protein
B6264_RS18920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6264_RS18925	COG0723	plastoquinol--plastocyanin reductase activity
B6264_RS18930	COG2010	Cytochrome c
B6264_RS18935	COG1845	cytochrome c oxidase, subunit III
B6264_RS18945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6264_RS19015	COG0003	Pfam Anion-transporting ATPase
B6264_RS19025	COG1940	carbohydrate kinase activity
B6264_RS19055	COG2197	response regulator
B6264_RS19065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6264_RS19070	COG0243	molybdopterin cofactor binding
B6264_RS19075	COG2193	ferroxidase activity
B6264_RS19085	COG0515	serine threonine protein kinase
B6264_RS19085	COG2815	serine threonine protein kinase
B6264_RS19090	COG2022	thiamine diphosphate biosynthetic process
B6264_RS19100	COG2022	thiamine diphosphate biosynthetic process
B6264_RS19100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6264_RS19115	COG0352	thiamine-phosphate diphosphorylase activity
B6264_RS19120	COG0142	geranyltranstransferase activity
B6264_RS19150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6264_RS19170	COG0714	Associated with various cellular activities
B6264_RS19180	COG0275	rRNA processing
B6264_RS19195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6264_RS19205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6264_RS19210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6264_RS19220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6264_RS19245	COG1799	cell septum assembly
B6264_RS19260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6264_RS19270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6264_RS19305	COG0640	Transcriptional regulator
B6264_RS19315	COG1522	sequence-specific DNA binding
B6264_RS19325	COG0590	tRNA wobble adenosine to inosine editing
B6264_RS19330	COG5504	Zn-dependent protease
B6264_RS19335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6264_RS19350	COG0587	DNA-directed DNA polymerase activity
B6264_RS19360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6264_RS19395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6264_RS19405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6264_RS19410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6264_RS19415	COG0131	Imidazoleglycerol-phosphate dehydratase
B6264_RS19420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6264_RS19425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6264_RS19430	COG0251	oxidation-reduction process
B6264_RS19435	COG0107	imidazoleglycerol-phosphate synthase activity
B6264_RS19460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6264_RS19465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6264_RS19490	COG0134	indole-3-glycerol-phosphate synthase activity
B6264_RS19495	COG0133	tryptophan synthase activity
B6264_RS19500	COG0159	tryptophan synthase activity
B6264_RS19520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6264_RS19530	COG0069	glutamate synthase activity
B6264_RS19530	COG0067	glutamate synthase
B6264_RS19530	COG0070	glutamate synthase
B6264_RS19545	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS19550	COG2207	Transcriptional regulator
B6264_RS19565	COG0737	Belongs to the 5'-nucleotidase family
B6264_RS19630	COG2050	protein possibly involved in aromatic compounds catabolism
B6264_RS19660	COG1643	Atp-dependent helicase
B6264_RS19665	COG2226	methyltransferase
B6264_RS19675	COG2409	Drug exporters of the RND superfamily
B6264_RS19690	COG0237	dephospho-CoA kinase activity
B6264_RS19705	COG0504	CTP synthase activity
B6264_RS19725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B6264_RS19750	COG4221	oxidoreductase activity
B6264_RS19760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6264_RS19835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6264_RS19845	COG0789	Transcriptional regulator
B6264_RS19850	COG3959	Transketolase, thiamine diphosphate binding domain
B6264_RS19855	COG3958	Transketolase
B6264_RS19895	COG0726	polysaccharide deacetylase
B6264_RS19905	COG2409	Drug exporters of the RND superfamily
B6264_RS19910	COG1278	Cold shock
B6264_RS19950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6264_RS19955	COG1116	anion transmembrane transporter activity
B6264_RS19980	COG0529	Catalyzes the synthesis of activated sulfate
B6264_RS19985	COG0175	sulfate reduction
B6264_RS20015	COG1162	GTPase activity
B6264_RS20025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6264_RS20045	COG0193	aminoacyl-tRNA hydrolase activity
B6264_RS20070	COG4106	trans-aconitate 2-methyltransferase activity
B6264_RS20075	COG1309	transcriptional regulator
B6264_RS20080	COG2957	Belongs to the agmatine deiminase family
B6264_RS20085	COG0804	urea catabolic process
B6264_RS20090	COG0832	Belongs to the urease beta subunit family
B6264_RS20090	COG0831	urea catabolic process
B6264_RS20125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6264_RS20125	COG1213	nucleotidyl transferase
B6264_RS20130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6264_RS20140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B6264_RS20160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6264_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS20215	COG4977	sequence-specific DNA binding
B6264_RS20250	COG1794	racemase activity, acting on amino acids and derivatives
B6264_RS20260	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B6264_RS20270	COG0681	Belongs to the peptidase S26 family
B6264_RS20290	COG1742	UPF0060 membrane protein
B6264_RS20295	COG0436	Aminotransferase
B6264_RS20315	COG1357	PFAM Pentapeptide repeats (8 copies)
B6264_RS20325	COG1309	transcriptional regulator
B6264_RS20335	COG0583	DNA-binding transcription factor activity
B6264_RS20370	COG2124	cytochrome p450
B6264_RS20375	COG2197	response regulator
B6264_RS20380	COG4585	Histidine kinase
B6264_RS20385	COG1136	(ABC) transporter
B6264_RS20385	COG0577	efflux transmembrane transporter activity
B6264_RS20390	COG1136	(ABC) transporter
B6264_RS20390	COG0577	efflux transmembrane transporter activity
B6264_RS20395	COG0181	hydroxymethylbilane synthase activity
B6264_RS20410	COG0242	peptide deformylase activity
B6264_RS20460	COG0667	Aldo Keto reductase
B6264_RS20470	COG0778	Nitroreductase
B6264_RS20475	COG0488	(ABC) transporter
B6264_RS20485	COG0488	(ABC) transporter
B6264_RS20495	COG2197	response regulator
B6264_RS20500	COG4585	Histidine kinase
B6264_RS20530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B6264_RS20535	COG1960	acyl-CoA dehydrogenase activity
B6264_RS20540	COG0183	Belongs to the thiolase family
B6264_RS20545	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6264_RS20545	COG1024	Enoyl-CoA hydratase
B6264_RS20560	COG2197	response regulator
B6264_RS20570	COG1136	(ABC) transporter
B6264_RS20570	COG0577	efflux transmembrane transporter activity
B6264_RS20580	COG0789	Transcriptional regulator
B6264_RS20585	COG0583	DNA-binding transcription factor activity
B6264_RS20610	COG2318	DinB family
B6264_RS20635	COG0587	DNA-directed DNA polymerase activity
B6264_RS20650	COG2197	response regulator
B6264_RS20655	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS20660	COG0789	Transcriptional regulator
B6264_RS20680	COG2910	NAD(P)H-binding
B6264_RS20685	COG3384	dioxygenase
B6264_RS20705	COG1609	Transcriptional regulator
B6264_RS20730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6264_RS20785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6264_RS20820	COG2259	Doxx family
B6264_RS20830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS20840	COG2837	iron assimilation
B6264_RS20855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6264_RS20870	COG1309	transcriptional regulator
B6264_RS20880	COG0640	Transcriptional regulator
B6264_RS20910	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B6264_RS20920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6264_RS20950	COG0667	Aldo Keto reductase
B6264_RS20955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS20960	COG0598	Magnesium transport protein CorA
B6264_RS20980	COG0215	cysteine-tRNA ligase activity
B6264_RS21000	COG1410	methionine synthase
B6264_RS21000	COG0646	methionine synthase
B6264_RS21015	COG2197	response regulator
B6264_RS21025	COG1994	Peptidase M50
B6264_RS21025	COG0517	IMP dehydrogenase activity
B6264_RS21045	COG1222	aaa ATPase
B6264_RS21050	COG4122	O-methyltransferase activity
B6264_RS21060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6264_RS21065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6264_RS21070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6264_RS21075	COG0545	Peptidyl-prolyl cis-trans isomerase
B6264_RS21085	COG0545	Peptidyl-prolyl cis-trans isomerase
B6264_RS21110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6264_RS21115	COG0805	protein transport
B6264_RS21120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6264_RS21140	COG3938	Belongs to the proline racemase family
B6264_RS21145	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS21160	COG1309	transcriptional regulator
B6264_RS21165	COG2084	Dehydrogenase
B6264_RS21170	COG1802	Transcriptional regulator
B6264_RS21180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6264_RS21190	COG4585	Histidine kinase
B6264_RS21195	COG2197	response regulator
B6264_RS21200	COG2070	2-Nitropropane dioxygenase
B6264_RS21205	COG0006	proline dipeptidase activity
B6264_RS21210	COG0747	negative chemotaxis
B6264_RS21215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6264_RS21220	COG0601	transmembrane transport
B6264_RS21225	COG0444	Belongs to the ABC transporter superfamily
B6264_RS21230	COG4608	Belongs to the ABC transporter superfamily
B6264_RS21240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6264_RS21260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6264_RS21270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6264_RS21275	COG0174	glutamine synthetase
B6264_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS21315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B6264_RS21320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6264_RS21325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6264_RS21330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6264_RS21335	COG5002	protein histidine kinase activity
B6264_RS21340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6264_RS21345	COG0072	phenylalanine-tRNA ligase activity
B6264_RS21345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6264_RS21350	COG1725	Transcriptional regulator
B6264_RS21355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B6264_RS21370	COG4213	ABC transporter substrate-binding protein
B6264_RS21380	COG0300	oxidoreductase activity
B6264_RS21415	COG2813	Specifically methylates the guanine in position
B6264_RS21420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6264_RS21425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6264_RS21430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6264_RS21435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6264_RS21440	COG1438	arginine binding
B6264_RS21445	COG0165	Argininosuccinate lyase
B6264_RS21460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6264_RS21465	COG2011	ABC-type metal ion transport system permease component
B6264_RS21470	COG1464	Belongs to the NlpA lipoprotein family
B6264_RS21485	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6264_RS21490	COG1648	precorrin-2 dehydrogenase activity
B6264_RS21490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6264_RS21495	COG3290	protein histidine kinase activity
B6264_RS21505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6264_RS21505	COG0515	serine threonine protein kinase
B6264_RS21545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6264_RS21545	COG0512	Glutamine amidotransferase of anthranilate synthase
B6264_RS21590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6264_RS21605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6264_RS21630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6264_RS21640	COG0438	transferase activity, transferring glycosyl groups
B6264_RS21655	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6264_RS21660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6264_RS21665	COG0217	transcriptional regulatory protein
B6264_RS21670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B6264_RS21675	COG0632	four-way junction helicase activity
B6264_RS21680	COG2255	four-way junction helicase activity
B6264_RS21690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6264_RS21695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6264_RS21700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6264_RS21705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6264_RS21710	COG1196	nuclear chromosome segregation
B6264_RS21715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6264_RS21725	COG0124	histidyl-tRNA synthetase
B6264_RS21730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6264_RS21740	COG2326	polyphosphate kinase activity
B6264_RS21750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6264_RS21775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6264_RS21780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6264_RS21800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6264_RS21805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6264_RS21810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6264_RS21815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6264_RS21820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B6264_RS21840	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B6264_RS21855	COG0006	proline dipeptidase activity
B6264_RS21860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6264_RS21865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6264_RS21885	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B6264_RS21890	COG0540	Belongs to the ATCase OTCase family
B6264_RS21895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6264_RS21905	COG0505	Belongs to the CarA family
B6264_RS21910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6264_RS21915	COG0167	dihydroorotate dehydrogenase activity
B6264_RS21920	COG0284	orotidine-5'-phosphate decarboxylase activity
B6264_RS21930	COG0194	GDP metabolic process
B6264_RS21960	COG0242	peptide deformylase activity
B6264_RS21965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6264_RS22025	COG0640	Transcriptional regulator
B6264_RS22050	COG0596	Alpha beta hydrolase
B6264_RS22065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6264_RS22095	COG0667	Aldo Keto reductase
B6264_RS22125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6264_RS22145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B6264_RS22150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6264_RS22155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6264_RS22175	COG3629	intracellular signal transduction
B6264_RS22175	COG3903	Transcriptional regulator
B6264_RS22180	COG3903	Transcriptional regulator
B6264_RS22180	COG3629	intracellular signal transduction
B6264_RS22195	COG2205	protein histidine kinase activity
B6264_RS22290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6264_RS22325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6264_RS22340	COG4948	Mandelate Racemase Muconate Lactonizing
B6264_RS22345	COG1846	Transcriptional regulator
B6264_RS22365	COG0640	Transcriptional regulator
B6264_RS22370	COG2814	Major facilitator Superfamily
B6264_RS22385	COG0656	L-ascorbic acid biosynthetic process
B6264_RS22390	COG2814	Major facilitator Superfamily
B6264_RS22405	COG2837	iron assimilation
B6264_RS22440	COG1937	Protein conserved in bacteria
B6264_RS22470	COG0701	Predicted permease
B6264_RS22490	COG1652	LysM domain
B6264_RS22530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS22545	COG0596	Alpha beta hydrolase
B6264_RS22550	COG1733	regulation of RNA biosynthetic process
B6264_RS22555	COG0702	epimerase
B6264_RS22575	COG3842	ATPase activity
B6264_RS22585	COG0515	serine threonine protein kinase
B6264_RS22605	COG0443	Heat shock 70 kDa protein
B6264_RS22620	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS22660	COG3209	COG3209 Rhs family protein
B6264_RS22710	COG2132	Multicopper oxidase
B6264_RS22725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6264_RS22770	COG0740	serine-type endopeptidase activity
B6264_RS22775	COG0740	serine-type endopeptidase activity
B6264_RS22780	COG1396	sequence-specific DNA binding
B6264_RS22795	COG2409	Drug exporters of the RND superfamily
B6264_RS22815	COG3511	phospholipase C
B6264_RS22880	COG0395	ABC-type sugar transport system, permease component
B6264_RS22895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6264_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS22920	COG0009	L-threonylcarbamoyladenylate synthase
B6264_RS22930	COG0516	GMP reductase activity
B6264_RS22930	COG0517	IMP dehydrogenase activity
B6264_RS22940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6264_RS22955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6264_RS22965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B6264_RS22970	COG2814	Major facilitator Superfamily
B6264_RS22995	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B6264_RS23000	COG2197	response regulator
B6264_RS23005	COG4585	Histidine kinase
B6264_RS23010	COG0577	efflux transmembrane transporter activity
B6264_RS23010	COG1136	(ABC) transporter
B6264_RS23030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6264_RS23035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B6264_RS23040	COG1216	Glycosyl transferase, family 2
B6264_RS23045	COG1984	allophanate hydrolase subunit 2
B6264_RS23055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B6264_RS23075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B6264_RS23125	COG0577	efflux transmembrane transporter activity
B6264_RS23125	COG1136	(ABC) transporter
B6264_RS23135	COG1285	pathogenesis
B6264_RS23140	COG3619	membrane
B6264_RS23155	COG1136	(ABC) transporter
B6264_RS23165	COG0494	nUDIX hydrolase
B6264_RS23185	COG4195	phage-related replication protein
B6264_RS23200	COG0564	pseudouridine synthase activity
B6264_RS23215	COG3424	synthase
B6264_RS23225	COG4221	oxidoreductase activity
B6264_RS23230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6264_RS23250	COG0477	Major facilitator Superfamily
B6264_RS23265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6264_RS23300	COG3201	nicotinamide mononucleotide transporter
B6264_RS23305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6264_RS23305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6264_RS23310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6264_RS23315	COG0140	phosphoribosyl-ATP diphosphatase activity
B6264_RS23320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6264_RS23355	COG1960	acyl-CoA dehydrogenase activity
B6264_RS23365	COG1522	sequence-specific DNA binding
B6264_RS23370	COG0402	S-adenosylhomocysteine deaminase activity
B6264_RS23415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B6264_RS23420	COG0494	nUDIX hydrolase
B6264_RS23455	COG0330	HflC and HflK could
B6264_RS23470	COG3226	Transcriptional regulator
B6264_RS23480	COG0277	FAD linked oxidase domain protein
B6264_RS23480	COG0247	lactate metabolic process
B6264_RS23485	COG1216	Glycosyl transferase, family 2
B6264_RS23495	COG1113	amino acid transport
B6264_RS23500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B6264_RS23530	COG0006	proline dipeptidase activity
B6264_RS23540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B6264_RS23545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6264_RS23550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6264_RS23580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6264_RS23590	COG1793	dna ligase
B6264_RS23600	COG1063	alcohol dehydrogenase
B6264_RS23605	COG0156	8-amino-7-oxononanoate synthase activity
B6264_RS23610	COG1073	alpha beta
B6264_RS23620	COG0583	DNA-binding transcription factor activity
B6264_RS23640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6264_RS23650	COG2226	methyltransferase
B6264_RS23665	COG4585	Histidine kinase
B6264_RS23670	COG2197	response regulator
B6264_RS23680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6264_RS23705	COG0318	PFAM AMP-dependent synthetase and ligase
B6264_RS23720	COG0477	Major facilitator Superfamily
B6264_RS23730	COG1799	cell septum assembly
B6264_RS23735	COG2318	DinB family
B6264_RS23745	COG2197	response regulator
B6264_RS23755	COG0738	Major facilitator superfamily
B6264_RS23775	COG0584	glycerophosphoryl diester phosphodiesterase
B6264_RS23790	COG4257	antibiotic catabolic process
B6264_RS23795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6264_RS23850	COG1686	Belongs to the peptidase S11 family
B6264_RS23875	COG0642	Histidine kinase
B6264_RS23880	COG0745	RESPONSE REGULATOR receiver
B6264_RS23910	COG1595	DNA-templated transcription, initiation
B6264_RS23915	COG0667	Aldo Keto reductase
B6264_RS23920	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS23925	COG1309	transcriptional regulator
B6264_RS23950	COG2124	cytochrome p450
B6264_RS23970	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B6264_RS23975	COG0776	regulation of translation
B6264_RS24015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B6264_RS24040	COG3387	PFAM Glycoside hydrolase 15-related
B6264_RS24045	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS24255	COG1073	alpha beta
B6264_RS24305	COG1476	TRANSCRIPTIONal
B6264_RS24310	COG0596	Alpha beta hydrolase
B6264_RS24315	COG0531	amino acid
B6264_RS24340	COG0154	amidase activity
B6264_RS24360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6264_RS24365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6264_RS24370	COG1192	Involved in chromosome partitioning
B6264_RS24455	COG0673	inositol 2-dehydrogenase activity
B6264_RS24495	COG0583	DNA-binding transcription factor activity
B6264_RS24525	COG0667	Aldo Keto reductase
B6264_RS24600	COG0667	Aldo Keto reductase
B6264_RS24725	COG2080	2 iron, 2 sulfur cluster binding
B6264_RS24725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6264_RS24765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B6264_RS24775	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS24805	COG3268	Saccharopine dehydrogenase
B6264_RS24865	COG2267	carboxylic ester hydrolase activity
B6264_RS24875	COG0577	efflux transmembrane transporter activity
B6264_RS24875	COG1136	(ABC) transporter
B6264_RS24905	COG3328	transposase activity
B6264_RS24920	COG1595	DNA-templated transcription, initiation
B6264_RS24945	COG3345	alpha-galactosidase
B6264_RS24950	COG2197	response regulator
B6264_RS24955	COG4585	Histidine kinase
B6264_RS24970	COG1309	transcriptional regulator
B6264_RS24990	COG3547	Transposase (IS116 IS110 IS902 family)
B6264_RS25015	COG3251	PFAM MbtH domain protein
B6264_RS25035	COG3424	synthase
B6264_RS25040	COG1024	Enoyl-CoA hydratase
B6264_RS25045	COG1024	Enoyl-CoA hydratase
B6264_RS25050	COG1024	Enoyl-CoA hydratase
B6264_RS25100	COG1733	regulation of RNA biosynthetic process
B6264_RS25105	COG2186	Transcriptional regulator
B6264_RS25120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6264_RS25125	COG1012	belongs to the aldehyde dehydrogenase family
B6264_RS25130	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS25145	COG0628	permease
B6264_RS25230	COG3321	synthase
B6264_RS25230	COG0604	alcohol dehydrogenase
B6264_RS25250	COG2890	protein-(glutamine-N5) methyltransferase activity
B6264_RS25270	COG0604	alcohol dehydrogenase
B6264_RS25270	COG3321	synthase
B6264_RS25290	COG2124	cytochrome p450
B6264_RS25295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6264_RS25310	COG2308	Evidence 4 Homologs of previously reported genes of
B6264_RS25310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B6264_RS25315	COG0367	asparagine synthase
B6264_RS25345	COG1295	ribonuclease BN
B6264_RS25355	COG0483	inositol monophosphate 1-phosphatase activity
B6264_RS25405	COG1846	Transcriptional regulator
B6264_RS25450	COG2197	response regulator
B6264_RS25465	COG1136	(ABC) transporter
B6264_RS25485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6264_RS25520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6264_RS25525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6264_RS25535	COG2132	Multicopper oxidase
B6264_RS25555	COG3387	PFAM Glycoside hydrolase 15-related
B6264_RS25625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6264_RS25645	COG1131	(ABC) transporter
B6264_RS25660	COG1846	Transcriptional regulator
B6264_RS25670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6264_RS25680	COG4249	Peptidase C14 caspase catalytic subunit p20
B6264_RS25680	COG2319	Wd-40 repeat
B6264_RS25920	COG1609	Transcriptional regulator
B6264_RS25930	COG1175	transmembrane transport
B6264_RS25935	COG0395	ABC-type sugar transport system, permease component
B6264_RS25965	COG0586	Pfam SNARE associated Golgi protein
B6264_RS25970	COG4585	Histidine kinase
B6264_RS25975	COG2197	response regulator
B6264_RS26010	COG0510	thiamine kinase activity
B6264_RS26030	COG0702	epimerase
B6264_RS26050	COG2826	transposase and inactivated derivatives, IS30 family
B6264_RS26090	COG4232	protein-disulfide reductase activity
B6264_RS26145	COG2909	trisaccharide binding
B6264_RS26160	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6264_RS26165	COG1129	ABC transporter
B6264_RS26175	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS26180	COG2186	Transcriptional regulator
B6264_RS26185	COG4948	Mandelate Racemase Muconate Lactonizing
B6264_RS26195	COG0800	Aldolase
B6264_RS26205	COG3386	PFAM SMP-30 Gluconolaconase
B6264_RS26210	COG3547	Transposase (IS116 IS110 IS902 family)
B6264_RS26290	COG1764	response to oxidative stress
B6264_RS26325	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B6264_RS26340	COG2909	trisaccharide binding
B6264_RS26350	COG1073	alpha beta
B6264_RS26355	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS26430	COG3328	transposase activity
B6264_RS26510	COG0604	alcohol dehydrogenase
B6264_RS26510	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS26510	COG3321	synthase
B6264_RS26645	COG1902	pentaerythritol trinitrate reductase activity
B6264_RS26650	COG1846	Transcriptional regulator
B6264_RS26710	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6264_RS26715	COG2814	Major facilitator Superfamily
B6264_RS26720	COG3629	intracellular signal transduction
B6264_RS26725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6264_RS26745	COG2175	clavaminate synthase activity
B6264_RS26750	COG0010	Belongs to the arginase family
B6264_RS26755	COG0367	asparagine synthase
B6264_RS26765	COG0667	Aldo Keto reductase
B6264_RS26775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6264_RS26795	COG2318	DinB family
B6264_RS26825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6264_RS26830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6264_RS26835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6264_RS26890	COG1231	oxidoreductase activity
B6264_RS26965	COG0456	acetyltransferase
B6264_RS26965	COG0454	-acetyltransferase
B6264_RS26985	COG2814	Major facilitator Superfamily
B6264_RS27045	COG0463	Glycosyl transferase, family 2
B6264_RS27050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6264_RS27085	COG1960	acyl-CoA dehydrogenase activity
B6264_RS27110	COG2226	methyltransferase
B6264_RS27115	COG1695	Transcriptional regulator
B6264_RS27125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B6264_RS27155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6264_RS27170	COG1802	Transcriptional regulator
B6264_RS27175	COG3265	gluconokinase activity
B6264_RS27190	COG1309	transcriptional regulator
B6264_RS27195	COG0402	S-adenosylhomocysteine deaminase activity
B6264_RS27200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6264_RS27205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6264_RS27210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6264_RS27215	COG1414	Transcriptional regulator
B6264_RS27220	COG2040	homocysteine
B6264_RS27235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6264_RS27240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6264_RS27275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6264_RS27315	COG2949	membrane
B6264_RS27320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6264_RS27325	COG0477	Major facilitator Superfamily
B6264_RS27335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6264_RS27335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6264_RS27370	COG0412	Dienelactone hydrolase
B6264_RS27375	COG0477	Major facilitator Superfamily
B6264_RS27420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6264_RS27425	COG0477	Major facilitator Superfamily
B6264_RS27430	COG1196	nuclear chromosome segregation
B6264_RS27430	COG0739	heme binding
B6264_RS27430	COG0741	lytic transglycosylase activity
B6264_RS27445	COG1414	Transcriptional regulator
B6264_RS27460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6264_RS27470	COG0366	Alpha amylase catalytic
B6264_RS27490	COG4585	Histidine kinase
B6264_RS27495	COG2197	response regulator
B6264_RS27505	COG0583	DNA-binding transcription factor activity
B6264_RS27510	COG2313	pseudouridylate synthase activity
B6264_RS27520	COG1796	DNA polymerase
B6264_RS27520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B6264_RS27560	COG0596	Alpha beta hydrolase
B6264_RS27565	COG1846	Transcriptional regulator
B6264_RS27575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6264_RS27590	COG4290	ribonuclease
B6264_RS27655	COG3473	Maleate cis-trans isomerase
B6264_RS27660	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6264_RS27670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6264_RS27700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B6264_RS27740	COG0438	transferase activity, transferring glycosyl groups
B6264_RS27745	COG0438	transferase activity, transferring glycosyl groups
B6264_RS27775	COG0747	negative chemotaxis
B6264_RS27780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6264_RS27795	COG4608	Belongs to the ABC transporter superfamily
B6264_RS27815	COG0583	DNA-binding transcription factor activity
B6264_RS27835	COG0531	amino acid
B6264_RS27845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B6264_RS27880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6264_RS27885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6264_RS27900	COG2329	Antibiotic biosynthesis monooxygenase
B6264_RS27910	COG0531	amino acid
B6264_RS27915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6264_RS27940	COG2838	Isocitrate dehydrogenase
B6264_RS27960	COG4941	Belongs to the sigma-70 factor family
B6264_RS27970	COG0477	Major facilitator Superfamily
B6264_RS27975	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS27980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6264_RS27985	COG2318	DinB family
B6264_RS28010	COG0205	6-phosphofructokinase activity
B6264_RS28015	COG3442	glutamine amidotransferase
B6264_RS28020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6264_RS28050	COG0076	glutamate decarboxylase activity
B6264_RS28060	COG0367	asparagine synthase
B6264_RS28070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6264_RS28075	COG2066	Belongs to the glutaminase family
B6264_RS28090	COG2318	DinB family
B6264_RS28105	COG0583	DNA-binding transcription factor activity
B6264_RS28145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6264_RS28170	COG3328	transposase activity
B6264_RS28195	COG3629	intracellular signal transduction
B6264_RS28195	COG3903	Transcriptional regulator
B6264_RS28200	COG0596	Alpha beta hydrolase
B6264_RS28205	COG0477	Major facilitator Superfamily
B6264_RS28220	COG1131	(ABC) transporter
B6264_RS28225	COG4585	Histidine kinase
B6264_RS28230	COG2197	response regulator
B6264_RS28245	COG1116	anion transmembrane transporter activity
B6264_RS28340	COG0640	Transcriptional regulator
B6264_RS28345	COG0384	phenazine biosynthesis protein PhzF
B6264_RS28370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6264_RS28395	COG3328	transposase activity
B6264_RS28435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6264_RS28450	COG0640	Transcriptional regulator
B6264_RS28465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6264_RS28475	COG0583	DNA-binding transcription factor activity
B6264_RS28485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6264_RS28515	COG1191	sigma factor activity
B6264_RS28540	COG2132	Multicopper oxidase
B6264_RS28585	COG0823	Involved in the tonB-independent uptake of proteins
B6264_RS28625	COG3629	intracellular signal transduction
B6264_RS28625	COG3903	Transcriptional regulator
B6264_RS28630	COG3629	intracellular signal transduction
B6264_RS28630	COG3903	Transcriptional regulator
B6264_RS28645	COG3511	phospholipase C
B6264_RS28655	COG1846	Transcriptional regulator
B6264_RS28685	COG0477	Major facilitator Superfamily
B6264_RS28720	COG1834	amidinotransferase
B6264_RS28725	COG1556	Lactate utilization protein
B6264_RS28730	COG1139	Iron-sulfur cluster binding protein
B6264_RS28735	COG0247	lactate metabolic process
B6264_RS28740	COG1017	nitric oxide dioxygenase activity
B6264_RS28740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B6264_RS28745	COG1959	2 iron, 2 sulfur cluster binding
B6264_RS28760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6264_RS28765	COG0363	glucosamine-6-phosphate deaminase activity
B6264_RS28815	COG0477	Major facilitator Superfamily
B6264_RS28820	COG0346	lactoylglutathione lyase activity
B6264_RS28850	COG1793	dna ligase
B6264_RS28850	COG3285	dna ligase
B6264_RS28865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6264_RS28890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6264_RS28895	COG2208	phosphoserine phosphatase activity
B6264_RS28915	COG1129	ABC transporter
B6264_RS28920	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6264_RS28935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6264_RS28970	COG3559	Exporter of polyketide antibiotics
B6264_RS28975	COG1131	(ABC) transporter
B6264_RS29005	COG2910	NAD(P)H-binding
B6264_RS29010	COG0697	spore germination
B6264_RS29015	COG1846	Transcriptional regulator
B6264_RS29020	COG2226	methyltransferase
B6264_RS29045	COG2124	cytochrome p450
B6264_RS29085	COG1316	TRANSCRIPTIONal
B6264_RS29120	COG0515	serine threonine protein kinase
B6264_RS29120	COG2815	serine threonine protein kinase
B6264_RS29130	COG1131	(ABC) transporter
B6264_RS29130	COG1716	ATPase activity
B6264_RS29130	COG0842	Transport permease protein
B6264_RS29160	COG0300	oxidoreductase activity
B6264_RS29165	COG0726	polysaccharide deacetylase
B6264_RS29185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6264_RS29190	COG2409	Drug exporters of the RND superfamily
B6264_RS29195	COG4585	Histidine kinase
B6264_RS29200	COG2197	response regulator
B6264_RS29220	COG1937	Protein conserved in bacteria
B6264_RS29250	COG0463	Glycosyl transferase, family 2
B6264_RS29315	COG1764	response to oxidative stress
B6264_RS29320	COG1846	Transcriptional regulator
B6264_RS29325	COG1595	DNA-templated transcription, initiation
B6264_RS29340	COG0137	argininosuccinate synthase activity
B6264_RS29370	COG2226	methyltransferase
B6264_RS29380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6264_RS29475	COG0534	Mate efflux family protein
B6264_RS29535	COG0586	Pfam SNARE associated Golgi protein
B6264_RS29540	COG0477	Major facilitator Superfamily
B6264_RS29545	COG0745	RESPONSE REGULATOR receiver
B6264_RS29550	COG2205	protein histidine kinase activity
B6264_RS29570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6264_RS29575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6264_RS29585	COG1104	cysteine desulfurase activity
B6264_RS29590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6264_RS29605	COG0531	amino acid
B6264_RS29640	COG3391	amine dehydrogenase activity
B6264_RS29680	COG1793	dna ligase
B6264_RS29735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6264_RS29775	COG1595	DNA-templated transcription, initiation
B6264_RS29800	COG3328	transposase activity
B6264_RS29805	COG1335	isochorismatase
B6264_RS29845	COG0583	DNA-binding transcription factor activity
B6264_RS29850	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS29875	COG0667	Aldo Keto reductase
B6264_RS29880	COG3328	transposase activity
B6264_RS30145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6264_RS30150	COG1518	maintenance of DNA repeat elements
B6264_RS30165	COG1857	crispr-associated protein
B6264_RS30215	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
B6264_RS30240	COG3634	alkyl hydroperoxide reductase activity
B6264_RS30380	COG1660	Displays ATPase and GTPase activities
B6264_RS30435	COG1192	Involved in chromosome partitioning
B6264_RS30515	COG3971	2-oxopent-4-enoate hydratase activity
B6264_RS30520	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B6264_RS30550	COG1733	regulation of RNA biosynthetic process
B6264_RS30555	COG0702	epimerase
B6264_RS30615	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B6264_RS30650	COG0587	DNA-directed DNA polymerase activity
B6264_RS30655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6264_RS30685	COG1028	Short-chain dehydrogenase reductase Sdr
B6264_RS30830	COG1733	regulation of RNA biosynthetic process
B6264_RS30935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6264_RS31035	COG3547	Transposase (IS116 IS110 IS902 family)
B6264_RS31060	COG2801	Transposase and inactivated derivatives