locus-tag class description G3H79_RS00030 ENOG4105MXW flavin reductase domain protein, FMN-binding G3H79_RS00040 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS00075 ENOG4105C26 Dehydrogenase G3H79_RS00085 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS00105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS00115 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G3H79_RS00140 ENOG4108JA1 polyketide synthase G3H79_RS00180 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3H79_RS00185 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS00225 ENOG4105D8K carboxyl transferase G3H79_RS00245 ENOG41064MX Tetr family transcriptional regulator G3H79_RS00265 ENOG4105VEQ Cold shock protein G3H79_RS00270 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3H79_RS00275 ENOG4108R85 Short chain dehydrogenase G3H79_RS00285 ENOG4105D29 Helix-turn-helix type 11 domain protein G3H79_RS00300 ENOG4105DV0 amidase (EC 3.5.1.4 G3H79_RS00315 ENOG4107S9F NmrA family G3H79_RS00320 ENOG4105CJA serine threonine protein kinase G3H79_RS00330 ENOG4105BZ1 (ABC) transporter G3H79_RS00355 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G3H79_RS00405 ENOG4105C0X amino acid G3H79_RS00410 ENOG4105D4M Lactamase_B G3H79_RS00470 ENOG41065SU Two-component system sensor kinase G3H79_RS00475 ENOG4108KXV response regulator G3H79_RS00490 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS00495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS00500 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) G3H79_RS00560 ENOG4105CPC Aldo Keto reductase G3H79_RS00570 ENOG4108MIC Mg-protoporphyrin IX methyl transferase G3H79_RS00580 ENOG4105C5Q Transcriptional regulator G3H79_RS00585 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3H79_RS00620 ENOG4108TM9 integral membrane protein G3H79_RS00640 ENOG4106T9R serine protease G3H79_RS00695 ENOG4105BZU Histidine kinase G3H79_RS00700 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G3H79_RS00710 ENOG4105CJA serine threonine protein kinase G3H79_RS00715 ENOG4105E8G Major facilitator Superfamily G3H79_RS00755 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G3H79_RS00765 ENOG4108KHK Glyoxalase Bleomycin resistance protein (Dioxygenase G3H79_RS00785 ENOG4105EX0 alpha-galactosidase G3H79_RS00795 ENOG4106A3M Cytochrome p-450 G3H79_RS00845 ENOG4105D8V Glucose sorbosone dehydrogenase G3H79_RS00850 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G3H79_RS00855 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G3H79_RS00860 ENOG4105C7W Xanthine dehydrogenase G3H79_RS00895 ENOG4105D17 glycoside hydrolase, family 3 domain protein G3H79_RS00950 ENOG4105K4I Scp-like extracellular G3H79_RS00975 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS00980 ENOG4106F60 Histidine kinase G3H79_RS01000 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS01045 ENOG4105DEN Luciferase family G3H79_RS01050 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3H79_RS01070 ENOG4105CHR reductase G3H79_RS01120 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS01140 ENOG410829K Lysine exporter protein (Lyse ygga) G3H79_RS01150 ENOG4105JZI cytochrome P450 G3H79_RS01155 ENOG4108X7A Terpene synthase metal-binding domain-containing protein G3H79_RS01185 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS01230 ENOG4105PGM cation diffusion facilitator family transporter G3H79_RS01250 ENOG4105FDP GntR family transcriptional regulator G3H79_RS01275 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3H79_RS01285 ENOG4105WBV Transcriptional regulator G3H79_RS01295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3H79_RS01300 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3H79_RS01315 ENOG4105DGI Alkaline phosphatase G3H79_RS01325 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS01340 ENOG4106NMR serine protease G3H79_RS01365 ENOG4105C2W permease G3H79_RS01370 ENOG4105YVS arsR family transcriptional regulator G3H79_RS01375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3H79_RS01380 ENOG4105CI2 imidazolone-5-propionate hydrolase G3H79_RS01430 ENOG4105F87 Dehydratase G3H79_RS01440 ENOG4105DKQ ROK family G3H79_RS01455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS01465 ENOG4107QK5 Homocysteine s-methyltransferase G3H79_RS01475 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G3H79_RS01480 ENOG4105RD7 BadF BadG BcrA BcrD G3H79_RS01490 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G3H79_RS01510 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 G3H79_RS01540 ENOG4105C71 hydrolase family 65, central catalytic G3H79_RS01560 ENOG4108IPT Naphthoate synthase G3H79_RS01570 ENOG4105C26 Dehydrogenase G3H79_RS01585 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G3H79_RS01595 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3H79_RS01610 ENOG4105CSR polyphosphate kinase 2 G3H79_RS01660 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3H79_RS01665 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3H79_RS01670 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3H79_RS01695 ENOG4105CDA abc transporter atp-binding protein G3H79_RS01700 ENOG4105EAB amino acid AbC transporter G3H79_RS01715 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G3H79_RS01720 ENOG4105C7W Xanthine dehydrogenase G3H79_RS01725 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G3H79_RS01730 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G3H79_RS01740 ENOG4105CPP Dehydrogenase, E1 component G3H79_RS01745 ENOG4107RUY (E1 component), alpha subunit G3H79_RS01750 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS01770 ENOG4108IQE Amp-dependent synthetase and ligase G3H79_RS01775 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS01790 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS01800 ENOG4108PA7 Methyltransferase G3H79_RS01810 ENOG4105ESN nucleotide-binding protein G3H79_RS01820 ENOG4105EMU Dehydrogenase G3H79_RS01860 ENOG4105CHR reductase G3H79_RS01865 ENOG4105C1B dTDP-glucose 4-6-dehydratase G3H79_RS01890 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3H79_RS01910 ENOG4107RCI amp-dependent synthetase and ligase G3H79_RS01925 ENOG4105CJA serine threonine protein kinase G3H79_RS01955 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3H79_RS01980 ENOG4107ZED Uncharacterised protein family UPF0047 G3H79_RS01985 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3H79_RS01990 ENOG4105E2Y ABC, transporter G3H79_RS02005 ENOG4105H3G oxidoreductase G3H79_RS02045 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS02055 ENOG4105BZ1 (ABC) transporter G3H79_RS02095 ENOG4105BZ1 (ABC) transporter G3H79_RS02100 ENOG4105DND Transcriptional regulator G3H79_RS02105 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3H79_RS02120 ENOG4105BZ1 (ABC) transporter G3H79_RS02125 ENOG4105BZ1 (ABC) transporter G3H79_RS02140 ENOG4105C29 acyl-CoA thioesterase G3H79_RS02155 ENOG4105GWZ Roadblock lc7 family protein G3H79_RS02185 ENOG4105BZU Histidine kinase G3H79_RS02230 ENOG4105C6T cysteine synthase G3H79_RS02275 ENOG4105C0D helicase G3H79_RS02295 ENOG4105C93 Xylose Isomerase G3H79_RS02300 ENOG4105CMG Carbohydrate kinase G3H79_RS02305 ENOG4105E2R ROK family G3H79_RS02315 ENOG4107RR1 TRANSCRIPTIONal G3H79_RS02320 ENOG4105C26 Dehydrogenase G3H79_RS02405 ENOG4108JA1 polyketide synthase G3H79_RS02460 ENOG4108KPJ rna polymerase sigma factor G3H79_RS02550 ENOG41061H0 Monooxygenase G3H79_RS02560 ENOG4107R13 MMPL domain protein G3H79_RS02610 ENOG4106A3M Cytochrome p-450 G3H79_RS02625 ENOG4108JJB ABC transporter G3H79_RS02650 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G3H79_RS02705 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3H79_RS02710 ENOG4107S5T Carbohydrate kinase G3H79_RS02715 ENOG4105CMG Carbohydrate kinase G3H79_RS02720 ENOG4105IE8 Alpha-ketoglutarate permease G3H79_RS02725 ENOG4105E98 transcriptional regulator DeoR family G3H79_RS02735 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS02740 ENOG4105C3U ABC transporter G3H79_RS02745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS02760 ENOG4105D2B acyl-CoA dehydrogenase G3H79_RS02765 ENOG4105D2B acyl-CoA dehydrogenase G3H79_RS02770 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS02780 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G3H79_RS02800 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G3H79_RS02805 ENOG4107QR9 Iron-sulfur cluster binding protein G3H79_RS02810 ENOG41080R8 Conserved Protein G3H79_RS02815 ENOG4108IJ8 ABC transporter G3H79_RS02820 ENOG4105FQP Beta-lactamase G3H79_RS02830 ENOG4105E90 ABC transporter G3H79_RS02835 ENOG4105E90 ABC transporter G3H79_RS02865 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G3H79_RS02870 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G3H79_RS02875 ENOG4105CG3 alpha amylase, catalytic region G3H79_RS02895 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF G3H79_RS02900 ENOG4107QVI Methyltransferase, type 11 G3H79_RS02915 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G3H79_RS02925 ENOG4106JDR secreted G3H79_RS02980 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3H79_RS03010 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS03015 ENOG4108M8W Monooxygenase G3H79_RS03030 ENOG4105CAQ asparagine synthetase G3H79_RS03065 ENOG4105CIR epoxide hydrolase G3H79_RS03075 ENOG4105EWC Purine nucleoside phosphorylase G3H79_RS03100 ENOG4105EUB pirin domain protein G3H79_RS03110 ENOG4105CGD Nad-dependent epimerase dehydratase G3H79_RS03115 ENOG4105CVP deoxyribo-dipyrimidine photolyase G3H79_RS03140 ENOG41083YR Protein CrcB homolog G3H79_RS03165 ENOG4105F0K SARP family transcriptional regulator G3H79_RS03170 ENOG4107QN2 dihydrolipoyl dehydrogenase G3H79_RS03175 ENOG41080RH Thioredoxin G3H79_RS03180 ENOG41060NJ transcriptional regulator G3H79_RS03200 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G3H79_RS03205 ENOG4108V75 Glutamine amidotransferase G3H79_RS03210 ENOG41067HS methyltransferase G3H79_RS03225 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G3H79_RS03240 ENOG4105DEN Luciferase family G3H79_RS03265 ENOG4105E33 succinate dehydrogenase G3H79_RS03280 ENOG4105C5Q Transcriptional regulator G3H79_RS03285 ENOG4105BZU Histidine kinase G3H79_RS03330 ENOG4105CRK lysyL-tRNA synthetase G3H79_RS03340 ENOG4105CUB amino acid G3H79_RS03390 ENOG4106T9R serine protease G3H79_RS03400 ENOG4105CJ1 ABC, transporter G3H79_RS03405 ENOG4105BZU Histidine kinase G3H79_RS03410 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS03420 ENOG4105KAF membrAne G3H79_RS03440 ENOG4105CHR reductase G3H79_RS03455 ENOG4105C2J ABC transporter G3H79_RS03465 ENOG41073TP transcriptional regulator G3H79_RS03485 ENOG4105DRS transport system, permease G3H79_RS03495 ENOG4105BZ7 extracellular solute-binding protein family 1 G3H79_RS03500 ENOG4107KJX Transcriptional regulator G3H79_RS03530 ENOG4105E2D ec 3.2.1.52 G3H79_RS03540 ENOG4105CVJ phosphoglycerate mutase G3H79_RS03575 ENOG4105CWX Alpha-1,2-mannosidase G3H79_RS03585 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS03590 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G3H79_RS03595 ENOG4105C2J ABC transporter G3H79_RS03600 ENOG4107R9N ABC transporter G3H79_RS03605 ENOG4105CNN ABC, transporter G3H79_RS03610 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G3H79_RS03615 ENOG4107QPH glycogen) synthase G3H79_RS03635 ENOG4105I82 acetyl xylan esterase G3H79_RS03640 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G3H79_RS03665 ENOG4105VEQ Cold shock protein G3H79_RS03685 ENOG4105EYF MMPL domain protein G3H79_RS03700 ENOG4105BZU Histidine kinase G3H79_RS03705 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS03710 ENOG4105BZU Histidine kinase G3H79_RS03730 ENOG4106A3M Cytochrome p-450 G3H79_RS03740 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS03850 ENOG4108UCS ABC, transporter G3H79_RS03875 ENOG4105BZ1 (ABC) transporter G3H79_RS03880 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G3H79_RS03895 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3H79_RS03925 ENOG4105DTD Dehydrogenase G3H79_RS03985 ENOG4108JA1 polyketide synthase G3H79_RS03995 ENOG4106A3M Cytochrome p-450 G3H79_RS04010 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase G3H79_RS04020 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS04055 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3H79_RS04065 ENOG4105K4I Scp-like extracellular G3H79_RS04080 ENOG4105DRS transport system, permease G3H79_RS04085 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G3H79_RS04095 ENOG4105E2R ROK family G3H79_RS04115 ENOG4105E7U AraC family transcriptional regulator G3H79_RS04120 ENOG4105D64 Mechanosensitive ion channel G3H79_RS04125 ENOG4105ESN nucleotide-binding protein G3H79_RS04125 ENOG4105ESN nucleotide-binding protein G3H79_RS04130 ENOG4105C9B Cysteine desulfurase G3H79_RS04140 ENOG4105CJ1 ABC, transporter G3H79_RS04145 ENOG4108RZE Tetr family transcriptional regulator G3H79_RS04160 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS04195 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS04200 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3H79_RS04230 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G3H79_RS04275 ENOG4105EYF MMPL domain protein G3H79_RS04285 ENOG4106A3M Cytochrome p-450 G3H79_RS04300 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS04305 ENOG4105CAS nag kinase G3H79_RS04310 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G3H79_RS04320 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) G3H79_RS04375 ENOG4105F0K SARP family transcriptional regulator G3H79_RS04390 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3H79_RS04410 ENOG4105CD8 aminopeptidase N G3H79_RS04460 ENOG4108IY8 ABC, transporter G3H79_RS04470 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component G3H79_RS04475 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS04480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G3H79_RS04485 ENOG4105CPQ Dehydrogenase G3H79_RS04490 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G3H79_RS04530 ENOG4105D82 Glutamate dehydrogenase G3H79_RS04545 ENOG41090WU lipolytic protein G-D-S-L family G3H79_RS04580 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G3H79_RS04595 ENOG4105EWU Squalene--hopene cyclase G3H79_RS04605 ENOG4107S11 squalene-associated FAD-dependent desaturase G3H79_RS04615 ENOG4105FBD synthase G3H79_RS04620 ENOG4105EY8 ABC transporter G3H79_RS04655 ENOG4105CMR udp-glucose 4-epimerase G3H79_RS04670 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G3H79_RS04705 ENOG4105BZM domain protein G3H79_RS04710 ENOG4105C5H ABC transporter G3H79_RS04725 ENOG4105C94 Transporter G3H79_RS04765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS04770 ENOG4105CHU acetyl-coa acetyltransferase G3H79_RS04775 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS04780 ENOG4105DYW oxidoreductase G3H79_RS04785 ENOG410846T CoA-transferase family III G3H79_RS04795 ENOG4105EG6 Saccharopine dehydrogenase G3H79_RS04800 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G3H79_RS04830 ENOG4105C5H ABC transporter G3H79_RS04835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3H79_RS04855 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G3H79_RS04875 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS04890 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS04910 ENOG4105DQE DNA ligase G3H79_RS04930 ENOG41067TZ transcriptional regulator, MarR family G3H79_RS04950 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G3H79_RS04955 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3H79_RS04970 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3H79_RS04980 ENOG4105E39 Enoyl-CoA hydratase G3H79_RS05005 ENOG4105F2C Acetyl-CoA acetyltransferase G3H79_RS05010 ENOG4108RZE Tetr family transcriptional regulator G3H79_RS05020 ENOG4105CC9 acyl-Coa dehydrogenase G3H79_RS05025 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS05035 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G3H79_RS05065 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G3H79_RS05095 ENOG4105F8D glycoside hydrolase family 4 G3H79_RS05105 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G3H79_RS05110 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3H79_RS05130 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein G3H79_RS05150 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3H79_RS05155 ENOG4105CXK mandelate racemase muconate lactonizing G3H79_RS05220 ENOG4105CPQ Dehydrogenase G3H79_RS05225 ENOG4105D17 glycoside hydrolase, family 3 domain protein G3H79_RS05230 ENOG4106A3M Cytochrome p-450 G3H79_RS05245 ENOG4105C26 Dehydrogenase G3H79_RS05255 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3H79_RS05275 ENOG4105FCD Major Facilitator G3H79_RS05280 ENOG4105FCD Major Facilitator G3H79_RS05315 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase G3H79_RS05355 ENOG4105CNN ABC, transporter G3H79_RS05360 ENOG4105C2J ABC transporter G3H79_RS05365 ENOG4105DKQ ROK family G3H79_RS05375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS05395 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3H79_RS05400 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3H79_RS05410 ENOG4107QHI -hydrogenase G3H79_RS05415 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G3H79_RS05420 ENOG4108478 ec 3.2.1.18 G3H79_RS05430 ENOG4105DHU Bile acid G3H79_RS05435 ENOG4105DUM transcriptional regulator, lysR family G3H79_RS05445 ENOG4105C57 major facilitator superfamily G3H79_RS05450 ENOG4108IQE Amp-dependent synthetase and ligase G3H79_RS05460 ENOG4108IV0 ABC, transporter G3H79_RS05465 ENOG4105C0Z ABC transporter G3H79_RS05470 ENOG4105DDI hemolysin-type calcium-binding region G3H79_RS05475 ENOG4105D8V Glucose sorbosone dehydrogenase G3H79_RS05480 ENOG4106UDK Cellulose-binding, family II G3H79_RS05505 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) G3H79_RS05510 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) G3H79_RS05555 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G3H79_RS05560 ENOG410842T Pterin carbinolamine dehydratase G3H79_RS05590 ENOG4105D5Q Arginine ornithine antiporter G3H79_RS05645 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3H79_RS05660 ENOG4105C5H ABC transporter G3H79_RS05675 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G3H79_RS05685 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G3H79_RS05710 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G3H79_RS05725 ENOG4105DIA mandelate racemase muconate lactonizing G3H79_RS05745 ENOG4107HQ7 repeat protein G3H79_RS05775 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G3H79_RS05785 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3H79_RS05790 ENOG4108ME1 Peptidase M55 D-aminopeptidase G3H79_RS05800 ENOG4108Q50 Histidine kinase G3H79_RS05885 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 G3H79_RS05895 ENOG4108JQ1 Dehydrogenase G3H79_RS05915 ENOG4105CAQ asparagine synthetase G3H79_RS05930 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS05935 ENOG4105BZU Histidine kinase G3H79_RS05980 ENOG4105KME endoribonuclease L-psp G3H79_RS05990 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS06010 ENOG4105CI0 Citrate lyase G3H79_RS06020 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS06025 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme G3H79_RS06035 ENOG4105BZW Glycerate kinase G3H79_RS06090 ENOG4105ECY inositol monophosphatase G3H79_RS06120 ENOG4106A3M Cytochrome p-450 G3H79_RS06155 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS06160 ENOG4105BZU Histidine kinase G3H79_RS06170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS06175 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G3H79_RS06185 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) G3H79_RS06190 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS06230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G3H79_RS06240 ENOG4105FF0 ErfK YbiS YcfS YnhG G3H79_RS06250 ENOG4105DRP amino acid AbC transporter G3H79_RS06255 ENOG4105EAD ABC transporter G3H79_RS06260 ENOG4107UBR Extracellular solute-binding protein family 3 G3H79_RS06265 ENOG4105CDA abc transporter atp-binding protein G3H79_RS06290 ENOG4105E8R UPF0173 metal-dependent hydrolase G3H79_RS06295 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G3H79_RS06305 ENOG41082A2 Alpha beta hydrolase G3H79_RS06325 ENOG4105DKQ ROK family G3H79_RS06330 ENOG4105C2J ABC transporter G3H79_RS06335 ENOG41062B0 ABC transporter, permease G3H79_RS06355 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G3H79_RS06370 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS06405 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G3H79_RS06410 ENOG4105DHG Allantoate amidinohydrolase G3H79_RS06420 ENOG4107HP6 Transcriptional regulator G3H79_RS06430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS06445 ENOG4107R9S Malate synthase G3H79_RS06475 ENOG4105CHM Aminotransferase G3H79_RS06485 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G3H79_RS06495 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3H79_RS06510 ENOG4107S5I aldo keto reductase G3H79_RS06535 ENOG4108HMN Caspase domain G3H79_RS06585 ENOG4105C2W permease G3H79_RS06590 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3H79_RS06595 ENOG4105C2W permease G3H79_RS06605 ENOG4105VT2 5-hydroxyisourate hydrolase G3H79_RS06625 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3H79_RS06630 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3H79_RS06635 ENOG4105CH6 catalase G3H79_RS06650 ENOG41060W2 glyoxylate carboligase G3H79_RS06660 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS06665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3H79_RS06675 ENOG410829K Lysine exporter protein (Lyse ygga) G3H79_RS06685 ENOG4105D7N magnesium and cobalt transport protein CorA G3H79_RS06695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3H79_RS06735 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G3H79_RS06830 ENOG4107QUT magnesium and cobalt transport protein CorA G3H79_RS06840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G3H79_RS06845 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G3H79_RS06855 ENOG4105K64 Glycosyl transferase, family 2 G3H79_RS06865 ENOG4105EQQ protein containing aminopeptidase domain G3H79_RS06880 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase G3H79_RS06890 ENOG4108I69 Glycosyl transferases group 1 G3H79_RS06910 ENOG4105CPQ Dehydrogenase G3H79_RS06935 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3H79_RS06940 ENOG4105D3Q Sugar transferase G3H79_RS06945 ENOG4108KGH TRANSCRIPTIONal G3H79_RS06950 ENOG4107QJZ Glycosyl transferase, family 2 G3H79_RS06960 ENOG4105DUM transcriptional regulator, lysR family G3H79_RS06965 ENOG4108SUT Major Facilitator Superfamily G3H79_RS06985 ENOG41062D9 Histidine kinase G3H79_RS06990 ENOG4105ETX regulatoR G3H79_RS07040 ENOG4105C7N Xanthine uracil vitamin C permease G3H79_RS07045 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3H79_RS07070 ENOG4105DRR Transcriptional regulator, GntR family G3H79_RS07095 ENOG4105CR4 methylisocitrate lyase G3H79_RS07100 ENOG4105C7K acetolactate synthase G3H79_RS07140 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3H79_RS07160 ENOG4108Z4K mutator MutT protein G3H79_RS07180 ENOG4107S9F NmrA family G3H79_RS07190 ENOG4105CSU acyl-Coa dehydrogenase G3H79_RS07195 ENOG4107RR1 TRANSCRIPTIONal G3H79_RS07215 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G3H79_RS07245 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3H79_RS07260 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3H79_RS07280 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS07290 ENOG4108VW9 Membrane G3H79_RS07295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS07370 ENOG4105Q36 FHA domain containing protein G3H79_RS07375 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3H79_RS07380 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G3H79_RS07390 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G3H79_RS07420 ENOG4105CPC Aldo Keto reductase G3H79_RS07435 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3H79_RS07445 ENOG4107NQ8 LysR family Transcriptional regulator G3H79_RS07450 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G3H79_RS07480 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G3H79_RS07490 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G3H79_RS07570 ENOG4105E0X reductase G3H79_RS07575 ENOG4105DFU Cell wall formation (By similarity) G3H79_RS07600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G3H79_RS07635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS07640 ENOG4105CVK Glutamate decarboxylase G3H79_RS07655 ENOG4105CIG ABC transporter G3H79_RS07715 ENOG4107JTW chlorite dismutase G3H79_RS07720 ENOG4105C1Q protoporphyrinogen oxidase G3H79_RS07730 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase G3H79_RS07750 ENOG4108IAJ Nad-dependent epimerase dehydratase G3H79_RS07770 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G3H79_RS07785 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G3H79_RS07790 ENOG4105CHU acetyl-coa acetyltransferase G3H79_RS07795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS07820 ENOG4105N98 Capsule biosynthesis protein capB G3H79_RS07830 ENOG4105PNM synthesis protein G3H79_RS07840 ENOG4105CUB amino acid G3H79_RS07845 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G3H79_RS07850 ENOG4108HWW ABC transporter G3H79_RS07855 ENOG4105C2J ABC transporter G3H79_RS07860 ENOG4105DFW ABC transporter G3H79_RS07865 ENOG4105E2R ROK family G3H79_RS07885 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS07910 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS07940 ENOG4107QM5 aconitate hydratase G3H79_RS07945 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS07955 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS07965 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3H79_RS08010 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3H79_RS08045 ENOG4108UKI Enoyl-CoA hydratase G3H79_RS08055 ENOG4105DBV ornithine carbamoyltransferase G3H79_RS08065 ENOG4107S1Q Phosphatase G3H79_RS08135 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS08150 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS08155 ENOG410846T CoA-transferase family III G3H79_RS08195 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS08210 ENOG4108JA1 polyketide synthase G3H79_RS08220 ENOG4105DMF Dehydrogenase G3H79_RS08240 ENOG4107VHA regulatoR G3H79_RS08250 ENOG4105C7W Xanthine dehydrogenase G3H79_RS08270 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G3H79_RS08275 ENOG4105C0X amino acid G3H79_RS08295 ENOG4107VEG TrkA-N domain protein G3H79_RS08330 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3H79_RS08335 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3H79_RS08340 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3H79_RS08355 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G3H79_RS08380 ENOG4106F60 Histidine kinase G3H79_RS08385 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS08395 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G3H79_RS08430 ENOG4107W53 thymidine kinase G3H79_RS08445 ENOG4105CD5 CoA-binding domain protein G3H79_RS08450 ENOG410849S phosphocarrier protein (HPr) G3H79_RS08455 ENOG4105DRR Transcriptional regulator, GntR family G3H79_RS08475 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3H79_RS08505 ENOG4105BZN citrate synthase G3H79_RS08510 ENOG4105BZN citrate synthase G3H79_RS08520 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G3H79_RS08525 ENOG4108MRH transcriptional regulatory protein G3H79_RS08530 ENOG4107QN1 sodium solute G3H79_RS08540 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS08545 ENOG4108ZGX Histidine kinase G3H79_RS08555 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3H79_RS08565 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap G3H79_RS08570 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS08575 ENOG4105JXH GntR family transcriptional regulator G3H79_RS08615 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3H79_RS08640 ENOG4105E0A ABC, transporter G3H79_RS08645 ENOG4105TVJ transport system, permease G3H79_RS08650 ENOG4105DQ5 transport system permease protein G3H79_RS08660 ENOG4105Q26 Siderophore-interacting protein G3H79_RS08665 ENOG4105WQI isochorismatase G3H79_RS08670 ENOG4105WQI isochorismatase G3H79_RS08675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G3H79_RS08680 ENOG4105E4F Isochorismate synthase G3H79_RS08685 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G3H79_RS08690 ENOG4105C9U ATP-dependent DNA helicase RecQ G3H79_RS08705 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3H79_RS08725 ENOG4108K79 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3H79_RS08735 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G3H79_RS08745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3H79_RS08750 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G3H79_RS08755 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G3H79_RS08795 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G3H79_RS08805 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3H79_RS08810 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G3H79_RS08820 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G3H79_RS08840 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G3H79_RS08855 ENOG4108WQI RNA Polymerase G3H79_RS08860 ENOG4105VBF alkaline shock protein G3H79_RS08895 ENOG4105EB3 Histidine kinase G3H79_RS08905 ENOG4105CDA abc transporter atp-binding protein G3H79_RS08910 ENOG4105CT1 (ABC) transporter G3H79_RS08915 ENOG4105EAD ABC transporter G3H79_RS08920 ENOG4105DRP amino acid AbC transporter G3H79_RS08935 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G3H79_RS08955 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G3H79_RS08960 ENOG4105DSF transport protein G3H79_RS08985 ENOG4106AXJ AraC family transcriptional regulator G3H79_RS08990 ENOG4107QRT dEAD DEAH box helicase G3H79_RS08995 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G3H79_RS09000 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3H79_RS09010 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G3H79_RS09015 ENOG4105WBV Transcriptional regulator G3H79_RS09020 ENOG4105CEV competence damage-inducible protein G3H79_RS09030 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G3H79_RS09040 ENOG4107QZI cell division protein FtsK G3H79_RS09045 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3H79_RS09050 ENOG4105BZU Histidine kinase G3H79_RS09085 ENOG4105CN5 Metallo-Beta-Lactamase G3H79_RS09090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3H79_RS09115 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G3H79_RS09120 ENOG4105C1V Peptidase, M16 G3H79_RS09125 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G3H79_RS09130 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G3H79_RS09145 ENOG4105EC2 ftsk spoIIIe G3H79_RS09220 ENOG4108T50 Protein of unknown function (DUF690) G3H79_RS09245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS09250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS09255 ENOG4105C3U ABC transporter G3H79_RS09275 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G3H79_RS09280 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G3H79_RS09290 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G3H79_RS09305 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) G3H79_RS09325 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase G3H79_RS09330 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G3H79_RS09350 ENOG4105DDI hemolysin-type calcium-binding region G3H79_RS09355 ENOG4108I5D sulfate abc transporter G3H79_RS09360 ENOG4105F38 ABC transporter, permease G3H79_RS09365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS09375 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS09380 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G3H79_RS09385 ENOG4105DZP Membrane-associated zinc metalloprotease G3H79_RS09390 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G3H79_RS09400 ENOG4105C26 Dehydrogenase G3H79_RS09405 ENOG4105G9B Transcriptional regulator G3H79_RS09445 ENOG4105CJP fad dependent oxidoreductase G3H79_RS09450 ENOG4105D38 putrescine abc transporter G3H79_RS09455 ENOG4105F38 ABC transporter, permease G3H79_RS09460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS09470 ENOG4105C26 Dehydrogenase G3H79_RS09480 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3H79_RS09485 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G3H79_RS09500 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G3H79_RS09505 ENOG4108IND Tetr family transcriptional regulator G3H79_RS09510 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G3H79_RS09515 ENOG4105R9B Major Facilitator G3H79_RS09520 ENOG4105CHR reductase G3H79_RS09530 ENOG4108CWB sugar kinase ygcE G3H79_RS09545 ENOG4105C26 Dehydrogenase G3H79_RS09555 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3H79_RS09560 ENOG4108I0Y (ABC) transporter G3H79_RS09585 ENOG4108UCS ABC, transporter G3H79_RS09590 ENOG4108I5D sulfate abc transporter G3H79_RS09600 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G3H79_RS09605 ENOG4105KNE Phosphatidate cytidylyltransferase G3H79_RS09610 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G3H79_RS09615 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G3H79_RS09620 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G3H79_RS09625 ENOG4105CE9 30S ribosomal protein S2 G3H79_RS09630 ENOG41063SB peptidase G3H79_RS09640 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS09655 ENOG41080R2 UPF0102 protein G3H79_RS09675 ENOG4107QYR Signal peptidase i G3H79_RS09680 ENOG4107QYR Signal peptidase i G3H79_RS09685 ENOG4107QYR Signal peptidase i G3H79_RS09690 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G3H79_RS09695 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G3H79_RS09700 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G3H79_RS09705 ENOG41082KU UPF0109 protein G3H79_RS09710 ENOG4105K5M 30s ribosomal protein S16 G3H79_RS09720 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) G3H79_RS09730 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3H79_RS09740 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G3H79_RS09785 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3H79_RS09795 ENOG4108375 Acylphosphatase (EC 3.6.1.7) G3H79_RS09800 ENOG4105K4I Scp-like extracellular G3H79_RS09810 ENOG4105KVH Transcriptional regulator G3H79_RS09815 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G3H79_RS09820 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G3H79_RS09825 ENOG41084BZ 50S ribosomal protein L32 G3H79_RS09840 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3H79_RS09845 ENOG4106H78 methyltransferase G3H79_RS09855 ENOG4105DP4 dak2 domain fusion protein ylov G3H79_RS09860 ENOG4105VB9 50S ribosomal protein l28 G3H79_RS09875 ENOG4105DWF phosphomethylpyrimidine kinase G3H79_RS09895 ENOG4105CPF Cell wall formation (By similarity) G3H79_RS09900 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G3H79_RS09920 ENOG4105K70 DNA-binding protein G3H79_RS09930 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3H79_RS09935 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3H79_RS09940 ENOG41069M3 Transcriptional regulator G3H79_RS09975 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G3H79_RS09980 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G3H79_RS09990 ENOG4105GWZ Roadblock lc7 family protein G3H79_RS10010 ENOG4105GWZ Roadblock lc7 family protein G3H79_RS10030 ENOG4105D8K carboxyl transferase G3H79_RS10065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3H79_RS10095 ENOG4105DWY Agmatine deiminase G3H79_RS10100 ENOG4105CQM Urea amidohydrolase subunit alpha G3H79_RS10120 ENOG4108IG5 Transcriptional regulator G3H79_RS10125 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3H79_RS10130 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3H79_RS10140 ENOG41080UQ Transcriptional regulator G3H79_RS10145 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3H79_RS10160 ENOG4105KNE Phosphatidate cytidylyltransferase G3H79_RS10175 ENOG4105C26 Dehydrogenase G3H79_RS10195 ENOG4105C57 major facilitator superfamily G3H79_RS10200 ENOG4108JQ1 Dehydrogenase G3H79_RS10205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G3H79_RS10210 ENOG4108ZP8 Acetolactate synthase small subunit G3H79_RS10225 ENOG4105BZU Histidine kinase G3H79_RS10235 ENOG4108FN7 Aldo keto reductase G3H79_RS10250 ENOG4107SM8 Adenylate Guanylate cyclase G3H79_RS10270 ENOG4105D9U N-acetyltransferase G3H79_RS10275 ENOG4105EYF MMPL domain protein G3H79_RS10280 ENOG4105HSS phospholipase C G3H79_RS10285 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS10295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS10300 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS10305 ENOG4108VJY integral membrane protein G3H79_RS10310 ENOG4105BZU Histidine kinase G3H79_RS10315 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G3H79_RS10325 ENOG4105EMU Dehydrogenase G3H79_RS10340 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS10360 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G3H79_RS10380 ENOG4105EJ2 Transcriptional regulator G3H79_RS10390 ENOG4105D29 Helix-turn-helix type 11 domain protein G3H79_RS10395 ENOG4105DND Transcriptional regulator G3H79_RS10405 ENOG4107ZR7 Membrane G3H79_RS10415 ENOG4105EN6 Membrane G3H79_RS10420 ENOG4108JQ7 (ABC) transporter G3H79_RS10425 ENOG4105C3U ABC transporter G3H79_RS10430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS10440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS10460 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G3H79_RS10465 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G3H79_RS10470 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G3H79_RS10475 ENOG4105EJQ L-serine dehydratase G3H79_RS10480 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C G3H79_RS10500 ENOG4108J4B Beta-lactamase G3H79_RS10540 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G3H79_RS10555 ENOG4106T9R serine protease G3H79_RS10560 ENOG4105BZ1 (ABC) transporter G3H79_RS10565 ENOG4105BZ1 (ABC) transporter G3H79_RS10580 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G3H79_RS10595 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS10600 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G3H79_RS10610 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G3H79_RS10615 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3H79_RS10630 ENOG4105W1Y Transcriptional regulator G3H79_RS10640 ENOG4107T4Z adenosine kinase G3H79_RS10645 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G3H79_RS10655 ENOG4107R13 MMPL domain protein G3H79_RS10660 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS10685 ENOG4105RXJ G3H79_RS10690 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3H79_RS10715 ENOG4105C57 major facilitator superfamily G3H79_RS10775 ENOG4107QJT sodium dicarboxylate symporter G3H79_RS10785 ENOG4108MRH transcriptional regulatory protein G3H79_RS10810 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound G3H79_RS10825 ENOG4105CTQ phosphohexokinase G3H79_RS10830 ENOG4105C6K Malic enzyme G3H79_RS10835 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G3H79_RS10870 ENOG4105C1B dTDP-glucose 4-6-dehydratase G3H79_RS10875 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G3H79_RS10880 ENOG4105ETX regulatoR G3H79_RS10900 ENOG4105WX6 Membrane G3H79_RS10920 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G3H79_RS10940 ENOG4107XI7 Tetr family transcriptional regulator G3H79_RS10990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS11005 ENOG4105CHU acetyl-coa acetyltransferase G3H79_RS11050 ENOG4108M8W Monooxygenase G3H79_RS11060 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) G3H79_RS11075 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS11080 ENOG410630P Transcriptional regulator G3H79_RS11100 ENOG4105IIP Membrane G3H79_RS11105 ENOG4105BZU Histidine kinase G3H79_RS11110 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS11120 ENOG4105EYF MMPL domain protein G3H79_RS11125 ENOG4105BZU Histidine kinase G3H79_RS11130 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS11140 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G3H79_RS11145 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G3H79_RS11150 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G3H79_RS11155 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G3H79_RS11160 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3H79_RS11165 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) G3H79_RS11170 ENOG4105ZA1 atp synthase G3H79_RS11180 ENOG4105Z3P ATP synthase G3H79_RS11190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G3H79_RS11195 ENOG4107ZF2 Phosphatase G3H79_RS11205 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3H79_RS11210 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G3H79_RS11215 ENOG4105VFB Binds the 23S rRNA (By similarity) G3H79_RS11230 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G3H79_RS11235 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G3H79_RS11240 ENOG4105D6E homoserine dehydrogenase G3H79_RS11245 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G3H79_RS11250 ENOG4105C75 arginyL-tRNA synthetase G3H79_RS11280 ENOG4105E8V Alpha Beta Hydrolase Fold protein G3H79_RS11285 ENOG4105FDF Could be involved in DNA repair (By similarity) G3H79_RS11290 ENOG4105DQE DNA ligase G3H79_RS11315 ENOG4108FKE two-component system sensor kinase G3H79_RS11330 ENOG4105CJN penicillin-binding protein G3H79_RS11350 ENOG4108IG5 Transcriptional regulator G3H79_RS11410 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3H79_RS11440 ENOG4108PYU two-component system response regulator G3H79_RS11445 ENOG4105EB3 Histidine kinase G3H79_RS11450 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G3H79_RS11500 ENOG4105CB2 alcohol dehydrogenase G3H79_RS11520 ENOG4105CDA abc transporter atp-binding protein G3H79_RS11525 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3H79_RS11540 ENOG4108VEQ Superoxide dismutase G3H79_RS11550 ENOG4108KPJ rna polymerase sigma factor G3H79_RS11585 ENOG4105ESN nucleotide-binding protein G3H79_RS11600 ENOG4105K6H D-cysteine desulfhydrase G3H79_RS11615 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G3H79_RS11630 ENOG4105CBD Diacylglycerol kinase G3H79_RS11645 ENOG4108IND Tetr family transcriptional regulator G3H79_RS11650 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G3H79_RS11655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3H79_RS11660 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G3H79_RS11665 ENOG4105D17 glycoside hydrolase, family 3 domain protein G3H79_RS11685 ENOG4105FDP GntR family transcriptional regulator G3H79_RS11690 ENOG4105D22 carbon starvation protein G3H79_RS11710 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3H79_RS11715 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3H79_RS11725 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS11730 ENOG41068W2 Cytochrome p-450 G3H79_RS11740 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3H79_RS11755 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3H79_RS11760 ENOG4105WMN AntiSigma factor G3H79_RS11765 ENOG4105EMN RNA polymerase sigma factor G3H79_RS11775 ENOG4108RAV Conserved protein G3H79_RS11785 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G3H79_RS11790 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3H79_RS11795 ENOG4105KPY Small multidrug resistance protein G3H79_RS11805 ENOG4107TK4 histidinol-phosphate phosphatase G3H79_RS11840 ENOG4105DJZ UPF0182 protein G3H79_RS11850 ENOG41063PX domain protein G3H79_RS11920 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G3H79_RS11945 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3H79_RS11975 ENOG4106JDR secreted G3H79_RS12015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS12025 ENOG4105DEF Extracellular solute-binding protein, family 5 G3H79_RS12065 ENOG4105C1J atp-dependent rna helicase G3H79_RS12070 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3H79_RS12080 ENOG41081FY multiple antibiotic resistance (MarC)-related G3H79_RS12095 ENOG4105DXB Major Facilitator superfamily G3H79_RS12105 ENOG4105D7N magnesium and cobalt transport protein CorA G3H79_RS12140 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G3H79_RS12145 ENOG4105C0H protease G3H79_RS12160 ENOG4105DU6 RNA polymerase G3H79_RS12175 ENOG4108UKI Enoyl-CoA hydratase G3H79_RS12180 ENOG4108R3E Dna-3-methyladenine glycosylase i G3H79_RS12190 ENOG4105EEI dihydropteroate synthase G3H79_RS12195 ENOG4108URH decarboxylase G3H79_RS12200 ENOG4107R4C succinyl-diaminopimelate desuccinylase G3H79_RS12220 ENOG4108Z4U Ferredoxin G3H79_RS12245 ENOG4105BZU Histidine kinase G3H79_RS12255 ENOG4108M15 ABC transporter G3H79_RS12270 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G3H79_RS12285 ENOG4108JQ7 (ABC) transporter G3H79_RS12290 ENOG4105C3U ABC transporter G3H79_RS12295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS12300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS12320 ENOG4108JQ7 (ABC) transporter G3H79_RS12330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS12335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS12345 ENOG4105CI3 gtp-binding protein typa G3H79_RS12365 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G3H79_RS12370 ENOG4105E33 succinate dehydrogenase G3H79_RS12385 ENOG41087YS Phage shock protein A G3H79_RS12420 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS12430 ENOG41067TZ transcriptional regulator, MarR family G3H79_RS12435 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G3H79_RS12450 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) G3H79_RS12490 ENOG4105C3G gtp-binding protein G3H79_RS12505 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G3H79_RS12515 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3H79_RS12520 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3H79_RS12525 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G3H79_RS12540 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G3H79_RS12550 ENOG4107GFK fumarate G3H79_RS12560 ENOG4105C9Q fumarate hydratase class II G3H79_RS12580 ENOG4105CH6 catalase G3H79_RS12585 ENOG4105BZ4 penicillin-binding protein G3H79_RS12595 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3H79_RS12610 ENOG4105D3R alkyl hydroperoxide reductase G3H79_RS12615 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS12630 ENOG4108IAB Phoh family G3H79_RS12635 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3H79_RS12640 ENOG4105CPC Aldo Keto reductase G3H79_RS12645 ENOG4105KVH Transcriptional regulator G3H79_RS12660 ENOG4108IUW ABC transporter G3H79_RS12680 ENOG4107QKZ Ompa motb domain protein G3H79_RS12815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3H79_RS12870 ENOG4105C6Z Gluconate G3H79_RS12875 ENOG4105KME endoribonuclease L-psp G3H79_RS12880 ENOG4108FUF Transcriptional regulator, IclR family G3H79_RS12915 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G3H79_RS12925 ENOG4105C57 major facilitator superfamily G3H79_RS12940 ENOG4105C7Z Conserved Protein G3H79_RS12970 ENOG4105T1M mycothiol conjugate amidase mca G3H79_RS12980 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G3H79_RS13010 ENOG4105C7B Threonine dehydratase G3H79_RS13015 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G3H79_RS13020 ENOG4105NAF rna polymerase sigma factor G3H79_RS13040 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G3H79_RS13055 ENOG4105DQ4 alcohol dehydrogenase G3H79_RS13070 ENOG4105KVH Transcriptional regulator G3H79_RS13125 ENOG4105DKQ ROK family G3H79_RS13130 ENOG4107QHQ amino acid G3H79_RS13135 ENOG4105C84 Histidine ammonia-lyase G3H79_RS13140 ENOG4105KDM Diguanylate cyclase with gaf sensor G3H79_RS13145 ENOG4105E39 Enoyl-CoA hydratase G3H79_RS13150 ENOG4108QER Adenylate cyclase G3H79_RS13160 ENOG4105D8K carboxyl transferase G3H79_RS13170 ENOG4107WR6 Maf-like protein G3H79_RS13180 ENOG4108JIK carboxylase G3H79_RS13210 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G3H79_RS13225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS13255 ENOG4105E2Z phosphate ABC transporter (Permease G3H79_RS13285 ENOG4105C26 Dehydrogenase G3H79_RS13290 ENOG4105C26 Dehydrogenase G3H79_RS13295 ENOG4105BZU Histidine kinase G3H79_RS13300 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS13315 ENOG4105NAF rna polymerase sigma factor G3H79_RS13320 ENOG4108KXV response regulator G3H79_RS13325 ENOG41065SU Two-component system sensor kinase G3H79_RS13350 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3H79_RS13395 ENOG4105D94 Major Facilitator Superfamily G3H79_RS13400 ENOG4107RSM transcriptional regulator G3H79_RS13435 ENOG4105UIB (ABC) transporter G3H79_RS13440 ENOG4108JQ9 ABC transporter G3H79_RS13445 ENOG4105DIH basic membrane G3H79_RS13450 ENOG4105DIH basic membrane G3H79_RS13455 ENOG4107RM1 amidohydrolase G3H79_RS13465 ENOG4108I69 Glycosyl transferases group 1 G3H79_RS13490 ENOG4105D2T synthase G3H79_RS13495 ENOG4105F0R Cytidylyltransferase G3H79_RS13505 ENOG4105K64 Glycosyl transferase, family 2 G3H79_RS13545 ENOG4108MMM RNA Polymerase G3H79_RS13575 ENOG4105E2D ec 3.2.1.52 G3H79_RS13595 ENOG4108J01 L-aspartate oxidase G3H79_RS13620 ENOG4108IUE nitrate reductase beta subunit G3H79_RS13665 ENOG4108MMM RNA Polymerase G3H79_RS13680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS13685 ENOG4105BZU Histidine kinase G3H79_RS13690 ENOG4107RN3 metallophosphoesterase G3H79_RS13740 ENOG4105C31 Tryptophanyl-tRNA synthetase G3H79_RS13750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G3H79_RS13755 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS13765 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3H79_RS13770 ENOG4108X0B nad(p)h dehydrogenase (quinone) G3H79_RS13845 ENOG4106032 Glutathionylspermidine synthase G3H79_RS13860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS13865 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS13870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS13895 ENOG4108HQS Glycine betaine G3H79_RS13900 ENOG4108IJ7 Glycine betaine G3H79_RS13925 ENOG4105VZ8 Transcriptional regulator G3H79_RS13935 ENOG4105C57 major facilitator superfamily G3H79_RS13955 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G3H79_RS13975 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS13980 ENOG4105BZU Histidine kinase G3H79_RS13990 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G3H79_RS14000 ENOG4105DC1 bifunctional purine biosynthesis protein purh G3H79_RS14035 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3H79_RS14050 ENOG4105DEG Vwa containing coxe family protein G3H79_RS14055 ENOG4105RD5 G3H79_RS14060 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G3H79_RS14110 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS14150 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3H79_RS14180 ENOG4105C26 Dehydrogenase G3H79_RS14185 ENOG4107TPY serine threonine protein kinase G3H79_RS14190 ENOG4108UGD Serine Threonine protein kinase G3H79_RS14195 ENOG4107TPY serine threonine protein kinase G3H79_RS14210 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3H79_RS14215 ENOG4107QQG Dehydrogenase G3H79_RS14225 ENOG4107QVP Dehydrogenase G3H79_RS14235 ENOG4108MMM RNA Polymerase G3H79_RS14240 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS14245 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G3H79_RS14250 ENOG4105DND Transcriptional regulator G3H79_RS14260 ENOG4105EMU Dehydrogenase G3H79_RS14265 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G3H79_RS14290 ENOG4105CHP RNA polymerase G3H79_RS14320 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3H79_RS14325 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G3H79_RS14345 ENOG4108097 ATP-binding protein G3H79_RS14355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3H79_RS14370 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3H79_RS14375 ENOG4105CS9 pantothenic acid kinase G3H79_RS14385 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3H79_RS14390 ENOG4108UJD 30S ribosomal protein S9 G3H79_RS14395 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G3H79_RS14410 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G3H79_RS14415 ENOG4108ZT0 50S ribosomal protein l17 G3H79_RS14420 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3H79_RS14425 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G3H79_RS14430 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G3H79_RS14435 ENOG41067V7 50S ribosomal protein L36 G3H79_RS14440 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G3H79_RS14450 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G3H79_RS14460 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G3H79_RS14465 ENOG410849U 50S ribosomal protein L30 G3H79_RS14470 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G3H79_RS14475 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G3H79_RS14480 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G3H79_RS14485 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G3H79_RS14495 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G3H79_RS14500 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G3H79_RS14505 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G3H79_RS14510 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G3H79_RS14515 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G3H79_RS14520 ENOG41082SA 50s ribosomal protein l29 G3H79_RS14525 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G3H79_RS14530 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G3H79_RS14535 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G3H79_RS14540 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G3H79_RS14545 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G3H79_RS14550 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G3H79_RS14555 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G3H79_RS14560 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G3H79_RS14565 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G3H79_RS14570 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3H79_RS14575 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G3H79_RS14580 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G3H79_RS14585 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G3H79_RS14595 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3H79_RS14600 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3H79_RS14605 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G3H79_RS14610 ENOG4108VZM 50s ribosomal protein L10 G3H79_RS14615 ENOG4105QCJ Lipoprotein G3H79_RS14625 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G3H79_RS14630 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G3H79_RS14640 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G3H79_RS14665 ENOG4107R4N Cell wall formation (By similarity) G3H79_RS14685 ENOG410900P UPF0336 protein G3H79_RS14690 ENOG4105WDJ 50S ribosomal protein L33 G3H79_RS14725 ENOG4108VPT UPF0234 protein G3H79_RS14730 ENOG4105Y3U Transglycosylase-associated protein G3H79_RS14740 ENOG410901E Membrane G3H79_RS14745 ENOG4105D0M Protease HtpX homolog G3H79_RS14750 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14755 ENOG4105C8S subunit m G3H79_RS14760 ENOG4105D65 subunit l G3H79_RS14765 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14775 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14780 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G3H79_RS14785 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3H79_RS14790 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14795 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3H79_RS14815 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G3H79_RS14820 ENOG4105DQU oxidoreductase, subunit beta G3H79_RS14825 ENOG4105KVH Transcriptional regulator G3H79_RS14830 ENOG4105ECR NmrA family G3H79_RS14855 ENOG4105KVH Transcriptional regulator G3H79_RS14865 ENOG41082W1 Cupin 2, conserved barrel domain protein G3H79_RS14870 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS14930 ENOG410667J hydrolase G3H79_RS14960 ENOG4105C9U ATP-dependent DNA helicase RecQ G3H79_RS14965 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14975 ENOG4105D65 subunit l G3H79_RS14980 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14985 ENOG41087XN oxidoreductase G3H79_RS14990 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS14995 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G3H79_RS15000 ENOG4108IEH NADH dehydrogenase subunit g G3H79_RS15005 ENOG4107QIZ NADH dehydrogenase G3H79_RS15015 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS15020 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3H79_RS15025 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS15060 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS15070 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G3H79_RS15115 ENOG4108EHY type IV secretion system G3H79_RS15135 ENOG4105I1F Resistance protein G3H79_RS15185 ENOG4105EC2 ftsk spoIIIe G3H79_RS15205 ENOG4105EV6 Pfam:DUF178 G3H79_RS15210 ENOG4105VEQ Cold shock protein G3H79_RS15225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS15230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS15260 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G3H79_RS15315 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G3H79_RS15400 ENOG4105CHR reductase G3H79_RS15415 ENOG4105CK2 sodium dicarboxylate symporter G3H79_RS15425 ENOG4105DVY radical SAM domain protein G3H79_RS15435 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G3H79_RS15440 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G3H79_RS15445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G3H79_RS15470 ENOG4105I6B RNA polymerase G3H79_RS15475 ENOG4105CRE cytochrome C G3H79_RS15480 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) G3H79_RS15490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3H79_RS15500 ENOG4108RH7 phosphoglycerate mutase G3H79_RS15505 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G3H79_RS15515 ENOG4105CJN penicillin-binding protein G3H79_RS15525 ENOG4107RSM transcriptional regulator G3H79_RS15555 ENOG4105KK4 UPF0060 membrane protein G3H79_RS15575 ENOG4105E0Y RtcB Protein G3H79_RS15640 ENOG4105DK7 lysyl-tRNA synthetase G3H79_RS15645 ENOG4105C75 arginyL-tRNA synthetase G3H79_RS15650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS15680 ENOG4105D52 delta-aminolevulinic acid dehydratase G3H79_RS15685 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3H79_RS15690 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3H79_RS15695 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G3H79_RS15700 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) G3H79_RS15745 ENOG4108XFF G3H79_RS15750 ENOG4105DGU Histone deacetylase G3H79_RS15755 ENOG4106UW1 Major Facilitator superfamily G3H79_RS15760 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G3H79_RS15780 ENOG4105C31 Tryptophanyl-tRNA synthetase G3H79_RS15785 ENOG4105II7 pyrroline-5-carboxylate reductase G3H79_RS15795 ENOG4105CJ1 ABC, transporter G3H79_RS15815 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein G3H79_RS15820 ENOG4105C01 Dihydroxy-acid dehydratase G3H79_RS15830 ENOG4105EY0 Xylose isomerase domain protein TIM barrel G3H79_RS15835 ENOG4107R33 ppx gppa phosphatase G3H79_RS15840 ENOG4108JWX G3H79_RS15855 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G3H79_RS15865 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3H79_RS15875 ENOG4105BZU Histidine kinase G3H79_RS15880 ENOG4105CEN a g-specific adenine glycosylase G3H79_RS15885 ENOG4105NAF rna polymerase sigma factor G3H79_RS15890 ENOG41075QH Lipoprotein CseA G3H79_RS15895 ENOG4108PYU two-component system response regulator G3H79_RS15900 ENOG4108FKE two-component system sensor kinase G3H79_RS15905 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily G3H79_RS15915 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS15920 ENOG4108IG5 Transcriptional regulator G3H79_RS15925 ENOG4105DR5 peptidase G3H79_RS15990 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G3H79_RS16000 ENOG4108IYU L-aspartate oxidase G3H79_RS16010 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G3H79_RS16020 ENOG4105C5W Aldolase G3H79_RS16030 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS16045 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3H79_RS16070 ENOG4105E90 ABC transporter G3H79_RS16075 ENOG4105E90 ABC transporter G3H79_RS16080 ENOG4108IJ8 ABC transporter G3H79_RS16090 ENOG4105CRK lysyL-tRNA synthetase G3H79_RS16125 ENOG4105EUJ GTP cyclohydrolase i G3H79_RS16135 ENOG4108UGV hypoxanthine phosphoribosyltransferase G3H79_RS16140 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G3H79_RS16155 ENOG4105F0N pyrophosphate phospho-hydrolase G3H79_RS16170 ENOG4107TXC Transcriptional regulator G3H79_RS16175 ENOG4105CVK Glutamate decarboxylase G3H79_RS16200 ENOG4105C26 Dehydrogenase G3H79_RS16220 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G3H79_RS16230 ENOG4105NRA 50s ribosomal protein l31 type b G3H79_RS16240 ENOG4105KDC 50s ribosomal protein l28 G3H79_RS16245 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G3H79_RS16275 ENOG4105C4K Nad synthetase G3H79_RS16285 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G3H79_RS16290 ENOG4105C2M dna polymerase I G3H79_RS16305 ENOG4108YYH Nadph-dependent fmn reductase G3H79_RS16315 ENOG4105BZU Histidine kinase G3H79_RS16320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS16325 ENOG4105F0K SARP family transcriptional regulator G3H79_RS16345 ENOG4105EBM Alpha Beta Hydrolase Fold protein G3H79_RS16360 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS16410 ENOG4108MMM RNA Polymerase G3H79_RS16440 ENOG4105CHR reductase G3H79_RS16465 ENOG4105C6E dna polymerase iii G3H79_RS16470 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G3H79_RS16475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G3H79_RS16485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3H79_RS16495 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for G3H79_RS16505 ENOG4105WN5 stage II sporulation protein G3H79_RS16510 ENOG4108I5C dEAD DEAH box helicase G3H79_RS16570 ENOG4105CHH sulfate transporter G3H79_RS16575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3H79_RS16580 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3H79_RS16590 ENOG4105D74 hydrolase G3H79_RS16605 ENOG4105P8F nudix hydrolase G3H79_RS16625 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3H79_RS16665 ENOG4105BZ4 penicillin-binding protein G3H79_RS16705 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G3H79_RS16710 ENOG4105DZR Type I site-specific deoxyribonuclease G3H79_RS16720 ENOG4105CVR type I restriction-modification system G3H79_RS16775 ENOG4108HMN Caspase domain G3H79_RS16840 ENOG4105E6M Sulphatase-modifying factor protein G3H79_RS16865 ENOG4105NAF rna polymerase sigma factor G3H79_RS16875 ENOG4105CFH Aspartokinase G3H79_RS16905 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G3H79_RS16910 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G3H79_RS16925 ENOG4105CKK Glycosyl transferase, family 2 G3H79_RS16935 ENOG4108JPW Aminotransferase G3H79_RS16965 ENOG4108V4B ThiJ pfpI G3H79_RS16975 ENOG4108762 serine threonine protein kinase G3H79_RS16980 ENOG4105CVA phosphate G3H79_RS16985 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G3H79_RS17005 ENOG4106A3M Cytochrome p-450 G3H79_RS17010 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS17015 ENOG4105BZU Histidine kinase G3H79_RS17025 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) G3H79_RS17040 ENOG4105C87 Aminotransferase class I and II G3H79_RS17045 ENOG4107RCW fructose-bisphosphate aldolase G3H79_RS17050 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G3H79_RS17065 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G3H79_RS17095 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3H79_RS17150 ENOG4105KNI merR family transcriptional Regulator G3H79_RS17155 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3H79_RS17160 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G3H79_RS17165 ENOG4105CFG Acts as a chaperone (By similarity) G3H79_RS17170 ENOG4105DF6 Fe-S oxidoreductase G3H79_RS17235 ENOG4105DHP deoxycytidine triphosphate deaminase G3H79_RS17245 ENOG4105CMD Transcriptional regulator, GntR family G3H79_RS17275 ENOG4105GFG DUF218 domain G3H79_RS17310 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G3H79_RS17330 ENOG4105G6Z alkaline phosphatase G3H79_RS17345 ENOG4108HMN Caspase domain G3H79_RS17355 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR G3H79_RS17370 ENOG4105VEQ Cold shock protein G3H79_RS17375 ENOG4105C1J atp-dependent rna helicase G3H79_RS17430 ENOG4105KWG Pfam:DUF1696 G3H79_RS17485 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G3H79_RS17490 ENOG4105KVH Transcriptional regulator G3H79_RS17495 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G3H79_RS17505 ENOG4105VMP Transcriptional regulator G3H79_RS17535 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G3H79_RS17540 ENOG4105C57 major facilitator superfamily G3H79_RS17565 ENOG4107RSM transcriptional regulator G3H79_RS17620 ENOG410613R integral membrane protein, YccS YhfK family G3H79_RS17630 ENOG4108KXM LysR family Transcriptional regulator G3H79_RS17655 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G3H79_RS17660 ENOG4105J7D transcriptional regulator G3H79_RS17720 ENOG4105C9M aspartyl-trna synthetase G3H79_RS17735 ENOG4105EUB pirin domain protein G3H79_RS17750 ENOG4105CSU acyl-Coa dehydrogenase G3H79_RS17755 ENOG4105DFM M18 family aminopeptidase G3H79_RS17780 ENOG4105C6F GntR Family Transcriptional Regulator G3H79_RS17790 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G3H79_RS17795 ENOG4105CPP Dehydrogenase, E1 component G3H79_RS17820 ENOG4107QPV Serine Threonine protein kinase G3H79_RS17825 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS17830 ENOG4108VC7 Protein of unknown function (DUF2587) G3H79_RS17845 ENOG4107SVH Potassium channel protein G3H79_RS17860 ENOG4107QSN dihydrolipoamide acetyltransferase G3H79_RS17880 ENOG4108IG5 Transcriptional regulator G3H79_RS17885 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS17910 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G3H79_RS17915 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G3H79_RS17920 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G3H79_RS17925 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G3H79_RS17930 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3H79_RS17960 ENOG4105TV9 FHA Domain-Containing protein G3H79_RS17965 ENOG4105HZM Fha domain containing protein G3H79_RS17980 ENOG4105CJN penicillin-binding protein G3H79_RS17990 ENOG4108RN7 integral membrane protein G3H79_RS17995 ENOG4108U4N (sortase) family G3H79_RS18005 ENOG4108U4N (sortase) family G3H79_RS18015 ENOG4105ZJT Cell division protein CrgA G3H79_RS18020 ENOG4107ZXI Rhomboid family G3H79_RS18045 ENOG4105BZU Histidine kinase G3H79_RS18050 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G3H79_RS18115 ENOG4107QPH glycogen) synthase G3H79_RS18120 ENOG4105D3Q Sugar transferase G3H79_RS18130 ENOG4105CJR Integral membrane protein (MviN G3H79_RS18140 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3H79_RS18170 ENOG4105S2J secreted protein G3H79_RS18170 ENOG4105S2J secreted protein G3H79_RS18215 ENOG4108UGD Serine Threonine protein kinase G3H79_RS18245 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3H79_RS18255 ENOG4105K7N UPF0232 protein G3H79_RS18260 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G3H79_RS18265 ENOG4108J5G 6-phosphogluconate dehydrogenase G3H79_RS18270 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3H79_RS18275 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G3H79_RS18280 ENOG41084CH 50S ribosomal protein l34 G3H79_RS18285 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G3H79_RS18290 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G3H79_RS18295 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3H79_RS18305 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G3H79_RS18310 ENOG4107QJE Chromosome Partitioning Protein G3H79_RS18325 ENOG4105K63 Thioredoxin G3H79_RS18330 ENOG4105C3M thioredoxin reductase G3H79_RS18360 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G3H79_RS18375 ENOG4105CZA synthase G3H79_RS18385 ENOG4105BZ4 penicillin-binding protein G3H79_RS18410 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G3H79_RS18415 ENOG4107YH6 single-stranded DNA-binding protein G3H79_RS18420 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G3H79_RS18425 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G3H79_RS18430 ENOG4107R73 Mate efflux family protein G3H79_RS18435 ENOG4105CDU Replicative dna helicase G3H79_RS18440 ENOG4105X1P Steroid delta-isomerase G3H79_RS18460 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) G3H79_RS18465 ENOG4105F27 Major Facilitator G3H79_RS18505 ENOG4105C28 cystathionine G3H79_RS18510 ENOG4105KJF protein tyrosine phosphatase G3H79_RS18515 ENOG41082T9 Membrane G3H79_RS18520 ENOG4106048 Cupin 2, conserved barrel domain protein G3H79_RS18535 ENOG4105KF0 sporulation and cell division protein, SsgA G3H79_RS18545 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G3H79_RS18565 ENOG4107P2S Transcriptional regulator G3H79_RS18570 ENOG4105CIH Imidazole acetol-phosphate transaminase G3H79_RS18575 ENOG4105C4M (Ubiquinol oxidase) subunit I G3H79_RS18580 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3H79_RS18585 ENOG4108JJ9 ABC, transporter G3H79_RS18595 ENOG4105E4C Lytic transglycosylase catalytic G3H79_RS18600 ENOG4108KP7 hydrolase G3H79_RS18615 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) G3H79_RS18620 ENOG4107SWG transcriptional regulator MERR family G3H79_RS18665 ENOG410667J hydrolase G3H79_RS18670 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G3H79_RS18675 ENOG4105CQC Prephenate dehydratase G3H79_RS18680 ENOG4105DBE peroxidase G3H79_RS18695 ENOG4108ZX6 Electron transport protein SCO1 SenC G3H79_RS18720 ENOG4105KVH Transcriptional regulator G3H79_RS18725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS18730 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS18735 ENOG4107T6F Xaa-Pro aminopeptidase G3H79_RS18755 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3H79_RS18770 ENOG4105C0H protease G3H79_RS18790 ENOG4105X7H acyl-CoA dehydrogenase G3H79_RS18820 ENOG4105NAF rna polymerase sigma factor G3H79_RS18825 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS18840 ENOG4108UXN response regulator G3H79_RS18870 ENOG4108KPJ rna polymerase sigma factor G3H79_RS18875 ENOG4105EQK -acetyltransferase G3H79_RS18905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS18910 ENOG4105BZU Histidine kinase G3H79_RS18920 ENOG4105EDW glycosyl transferase, family 39 G3H79_RS18925 ENOG4105C57 major facilitator superfamily G3H79_RS18935 ENOG410905P Pyridoxamine 5-phosphate G3H79_RS18945 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS18950 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G3H79_RS18965 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS18970 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS18975 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein G3H79_RS19000 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G3H79_RS19015 ENOG4105D7A ATP-binding protein G3H79_RS19025 ENOG4105C5H ABC transporter G3H79_RS19040 ENOG4107RSM transcriptional regulator G3H79_RS19045 ENOG4105FDR Membrane G3H79_RS19055 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3H79_RS19065 ENOG41082SX arsR family transcriptional regulator G3H79_RS19185 ENOG4106CY5 excisionase G3H79_RS19210 ENOG4105C12 Phosphoribosylglycinamide synthetase G3H79_RS19225 ENOG4105C8V SAICAR synthetase G3H79_RS19270 ENOG410839H phosphoribosylformylglycinamidine synthase G3H79_RS19275 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G3H79_RS19280 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G3H79_RS19315 ENOG4105CXB phosphoribosylaminoimidazole synthetase G3H79_RS19330 ENOG4108TAC G3H79_RS19350 ENOG4105CQ7 ATP-dependent helicase G3H79_RS19360 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3H79_RS19365 ENOG4107QIV Cytochrome c biogenesis protein G3H79_RS19400 ENOG4105C1J atp-dependent rna helicase G3H79_RS19475 ENOG410880H cysteine synthase G3H79_RS19495 ENOG4105CPC Aldo Keto reductase G3H79_RS19505 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3H79_RS19510 ENOG4105D5U fad dependent oxidoreductase G3H79_RS19575 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS19580 ENOG4105BZU Histidine kinase G3H79_RS19590 ENOG4105CJ1 ABC, transporter G3H79_RS19635 ENOG4108XET gCN5-related N-acetyltransferase G3H79_RS19650 ENOG4108JJB ABC transporter G3H79_RS19665 ENOG4105E4C Lytic transglycosylase catalytic G3H79_RS19670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3H79_RS19675 ENOG4105DNP FAD linked oxidase domain protein G3H79_RS19690 ENOG4105VPX protein, conserved in bacteria G3H79_RS19700 ENOG4105CJ3 phosphate transporter G3H79_RS19710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS19740 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G3H79_RS19750 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS19760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G3H79_RS19765 ENOG4105CGH 5'-nucleotidase G3H79_RS19785 ENOG4105ETX regulatoR G3H79_RS19790 ENOG4105C0H protease G3H79_RS19795 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS19800 ENOG4107NHD transcriptional regulator G3H79_RS19825 ENOG4105KHC sulfurtransferase G3H79_RS19830 ENOG4105PKJ carbohydrate binding G3H79_RS19840 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G3H79_RS19845 ENOG41090R7 Ferric uptake G3H79_RS19850 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G3H79_RS19855 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G3H79_RS19875 ENOG4105FDP GntR family transcriptional regulator G3H79_RS19930 ENOG4105C4R Atp-dependent dna helicase G3H79_RS19970 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3H79_RS19980 ENOG4108KPJ rna polymerase sigma factor G3H79_RS20000 ENOG4105TT9 Protein of unknown function (DUF2516) G3H79_RS20020 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3H79_RS20025 ENOG4108YZJ Pfam:DUF2596 G3H79_RS20030 ENOG4105QNJ serralysin (EC 3.4.24.40) G3H79_RS20050 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3H79_RS20060 ENOG4105BZU Histidine kinase G3H79_RS20080 ENOG4108VJ1 Transcriptional regulator (CarD family G3H79_RS20085 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G3H79_RS20090 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G3H79_RS20095 ENOG410905P Pyridoxamine 5-phosphate G3H79_RS20100 ENOG4105C8N cysteinyl-tRNA synthetase G3H79_RS20105 ENOG4105C2N RNA methyltransferase TrmH family group 3 G3H79_RS20115 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G3H79_RS20135 ENOG4105CJP fad dependent oxidoreductase G3H79_RS20180 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS20220 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G3H79_RS20230 ENOG4105BZU Histidine kinase G3H79_RS20245 ENOG4105CE4 GlcNAc 6-P deacetylase G3H79_RS20275 ENOG4105C3Q Glycosyl transferase, family 2 G3H79_RS20280 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G3H79_RS20295 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G3H79_RS20335 ENOG4105EMN RNA polymerase sigma factor G3H79_RS20345 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G3H79_RS20350 ENOG4106G6Q Transcriptional regulator G3H79_RS20370 ENOG4105KNA -acetyltransferase G3H79_RS20395 ENOG4106N3A copper homeostasis protein cutc G3H79_RS20400 ENOG4105EEM helicase G3H79_RS20410 ENOG4105CFI type iii restriction protein res subunit G3H79_RS20435 ENOG4108MES Periplasmic binding protein G3H79_RS20440 ENOG4105E0A ABC, transporter G3H79_RS20445 ENOG4105TVJ transport system, permease G3H79_RS20450 ENOG4105DQ5 transport system permease protein G3H79_RS20465 ENOG4105VEQ Cold shock protein G3H79_RS20470 ENOG4105E63 Pfam:DUF178 G3H79_RS20475 ENOG4108UIH futalosine nucleosidase G3H79_RS20485 ENOG4108N0W Major Facilitator superfamily G3H79_RS20510 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G3H79_RS20520 ENOG4105C7N Xanthine uracil vitamin C permease G3H79_RS20555 ENOG4105CPC Aldo Keto reductase G3H79_RS20640 ENOG4105ECP epimerase G3H79_RS20660 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G3H79_RS20670 ENOG4105CQB FAD linked oxidase domain protein G3H79_RS20695 ENOG4107QX3 carboxylase G3H79_RS20740 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G3H79_RS20745 ENOG4108XEP Alpha Beta Hydrolase Fold protein G3H79_RS20755 ENOG4108SU4 UPF0309 protein G3H79_RS20760 ENOG4106F60 Histidine kinase G3H79_RS20765 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS20780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS20785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS20815 ENOG4105CJ1 ABC, transporter G3H79_RS20860 ENOG41082AN stage II sporulation protein G3H79_RS20870 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS20875 ENOG4105CC9 acyl-Coa dehydrogenase G3H79_RS20880 ENOG4105D2B acyl-CoA dehydrogenase G3H79_RS20900 ENOG4105CC9 acyl-Coa dehydrogenase G3H79_RS20930 ENOG4105MXW flavin reductase domain protein, FMN-binding G3H79_RS20935 ENOG4105CGU Enoyl-CoA hydratase G3H79_RS20945 ENOG4105H3G oxidoreductase G3H79_RS20985 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G3H79_RS20995 ENOG4108762 serine threonine protein kinase G3H79_RS21015 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS21080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G3H79_RS21095 ENOG4105YVS arsR family transcriptional regulator G3H79_RS21110 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G3H79_RS21125 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase G3H79_RS21185 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS21220 ENOG4105DZ1 carboxypeptidase G3H79_RS21230 ENOG4105EPJ extracellular solute-binding protein family 1 G3H79_RS21240 ENOG4108V5V Serine Threonine protein kinase G3H79_RS21250 ENOG4105BZ4 penicillin-binding protein G3H79_RS21275 ENOG4105S2J secreted protein G3H79_RS21290 ENOG4105EUZ Beta-lactamase domain protein G3H79_RS21320 ENOG4107QJE Chromosome Partitioning Protein G3H79_RS21375 ENOG4105C26 Dehydrogenase G3H79_RS21455 ENOG4105E98 transcriptional regulator DeoR family G3H79_RS21460 ENOG4105DE4 1-phosphofructokinase G3H79_RS21465 ENOG4105DM4 PTS System G3H79_RS21485 ENOG4105FF0 ErfK YbiS YcfS YnhG G3H79_RS21490 ENOG4105KXX peptidase s58 dmpa G3H79_RS21505 ENOG4105F1A Pyruvate formate-lyase G3H79_RS21525 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G3H79_RS21540 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) G3H79_RS21545 ENOG4105CUJ penicillin amidase G3H79_RS21550 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G3H79_RS21555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G3H79_RS21565 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3H79_RS21570 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3H79_RS21575 ENOG4105D9U N-acetyltransferase G3H79_RS21590 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS21595 ENOG4108KPJ rna polymerase sigma factor G3H79_RS21600 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3H79_RS21610 ENOG4108FKE two-component system sensor kinase G3H79_RS21620 ENOG4105CGK Exodeoxyribonuclease III G3H79_RS21635 ENOG4105F95 Monooxygenase G3H79_RS21640 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3H79_RS21645 ENOG4108BAS reductase G3H79_RS21665 ENOG4105EYF MMPL domain protein G3H79_RS21675 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) G3H79_RS21685 ENOG4108JJB ABC transporter G3H79_RS21700 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G3H79_RS21730 ENOG4105F8V Hydrolase, tatD family G3H79_RS21735 ENOG41069ER domain protein G3H79_RS21740 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3H79_RS21745 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G3H79_RS21750 ENOG4105C5H ABC transporter G3H79_RS21790 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G3H79_RS21800 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS21805 ENOG4108ZT1 Transcriptional regulator G3H79_RS21810 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G3H79_RS21820 ENOG41067SE Tetr family transcriptional regulator G3H79_RS21830 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G3H79_RS21840 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G3H79_RS21845 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G3H79_RS21850 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3H79_RS21855 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G3H79_RS21865 ENOG4108ZGX Histidine kinase G3H79_RS21910 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS21915 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS21975 ENOG4106A3M Cytochrome p-450 G3H79_RS21990 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G3H79_RS22015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3H79_RS22020 ENOG4107RBB ABC transporter, permease G3H79_RS22025 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS22065 ENOG4105CHU acetyl-coa acetyltransferase G3H79_RS22090 ENOG4105ETS cytosine purines uracil thiamine allantoin G3H79_RS22100 ENOG4105E90 ABC transporter G3H79_RS22105 ENOG4105E90 ABC transporter G3H79_RS22110 ENOG4108IJ8 ABC transporter G3H79_RS22145 ENOG4105CGP Urocanate hydratase G3H79_RS22160 ENOG4105CI2 imidazolone-5-propionate hydrolase G3H79_RS22205 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS22210 ENOG41082AN stage II sporulation protein G3H79_RS22245 ENOG4105DUX Transporter G3H79_RS22250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS22255 ENOG41065SU Two-component system sensor kinase G3H79_RS22290 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3H79_RS22310 ENOG4108KGH TRANSCRIPTIONal G3H79_RS22335 ENOG4108KGH TRANSCRIPTIONal G3H79_RS22340 ENOG4108KGH TRANSCRIPTIONal G3H79_RS22355 ENOG4108S0S Nucleotidyl transferase G3H79_RS22395 ENOG4108IG5 Transcriptional regulator G3H79_RS22435 ENOG4108D32 Methyltransferase G3H79_RS22485 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G3H79_RS22500 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G3H79_RS22505 ENOG4107RGC Glycosyl transferase, family 2 G3H79_RS22525 ENOG4105DAA L-lactate G3H79_RS22530 ENOG4107QKV phosphomannomutase G3H79_RS22535 ENOG4105W49 UPF0434 protein G3H79_RS22545 ENOG4105EIP mannose-6-phosphate isomerase G3H79_RS22555 ENOG4105DM4 PTS System G3H79_RS22560 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G3H79_RS22600 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3H79_RS22605 ENOG4108WQ6 secreted protein G3H79_RS22620 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G3H79_RS22625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS22635 ENOG4105G3P Lipoprotein lpqB G3H79_RS22645 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G3H79_RS22650 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS22655 ENOG4105T0Z Conserved Protein G3H79_RS22665 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3H79_RS22690 ENOG4105C7I Dehydrogenase G3H79_RS22695 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) G3H79_RS22710 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3H79_RS22720 ENOG4105K64 Glycosyl transferase, family 2 G3H79_RS22725 ENOG4107SJB teichoic acid biosynthesis G3H79_RS22730 ENOG4105EY8 ABC transporter G3H79_RS22750 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS22765 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS22770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3H79_RS22790 ENOG4107SJB teichoic acid biosynthesis G3H79_RS22795 ENOG4107SJB teichoic acid biosynthesis G3H79_RS22800 ENOG4108I69 Glycosyl transferases group 1 G3H79_RS22815 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G3H79_RS22835 ENOG4108UGD Serine Threonine protein kinase G3H79_RS22840 ENOG4108QVN serine threonine protein kinase G3H79_RS22845 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G3H79_RS22860 ENOG4105CAK Cell division ATP-binding protein ftsE G3H79_RS22870 ENOG4105CN1 protease G3H79_RS22875 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G3H79_RS22885 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family G3H79_RS22895 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS22985 ENOG4105EEM helicase G3H79_RS22995 ENOG4108426 dNA-binding protein G3H79_RS23000 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3H79_RS23005 ENOG4108UJU UPF0301 protein G3H79_RS23010 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS23015 ENOG4108RWP Major Facilitator Superfamily protein G3H79_RS23025 ENOG4105E2D ec 3.2.1.52 G3H79_RS23110 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS23120 ENOG41086VY Fic/DOC family G3H79_RS23135 ENOG41063PX domain protein G3H79_RS23150 ENOG4105E90 ABC transporter G3H79_RS23155 ENOG4108IJ8 ABC transporter G3H79_RS23160 ENOG4105E90 ABC transporter G3H79_RS23170 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase G3H79_RS23180 ENOG4105CQB FAD linked oxidase domain protein G3H79_RS23185 ENOG4105KF0 sporulation and cell division protein, SsgA G3H79_RS23215 ENOG4108RWI nicotinamidase G3H79_RS23225 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G3H79_RS23235 ENOG4105C85 amino acid G3H79_RS23250 ENOG4105EHG Permease protein G3H79_RS23255 ENOG4105E0A ABC, transporter G3H79_RS23275 ENOG4108RQ5 Beta-lactamase domain-containing protein G3H79_RS23295 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G3H79_RS23305 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G3H79_RS23325 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G3H79_RS23335 ENOG4105BZ4 penicillin-binding protein G3H79_RS23365 ENOG4106BRA Membrane G3H79_RS23390 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS23475 ENOG4108U4N (sortase) family G3H79_RS23485 ENOG4105E1V na solute symporter G3H79_RS23505 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3H79_RS23510 ENOG4105ERH Fumarylacetoacetate hydrolase G3H79_RS23520 ENOG41090KN UPF0303 protein G3H79_RS23525 ENOG4105D9R oxidoreductase G3H79_RS23530 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) G3H79_RS23540 ENOG41080U6 GntR family transcriptional regulator G3H79_RS23545 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3H79_RS23555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS23565 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component G3H79_RS23610 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G3H79_RS23625 ENOG4105JXH GntR family transcriptional regulator G3H79_RS23650 ENOG4108M1A Chitin-binding protein G3H79_RS23655 ENOG4105J5T Amp-dependent synthetase and ligase G3H79_RS23665 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS23675 ENOG4107R13 MMPL domain protein G3H79_RS23680 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS23685 ENOG4105BZU Histidine kinase G3H79_RS23695 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G3H79_RS23735 ENOG4105C19 ABC transporter G3H79_RS23745 ENOG4105QV4 Tryptophan halogenase G3H79_RS23770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3H79_RS23780 ENOG4105CHR reductase G3H79_RS23810 ENOG4105DK0 Indole-3-glycerol phosphate synthase G3H79_RS23815 ENOG4107S1N anthranilate phosphoribosyltransferase G3H79_RS23835 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G3H79_RS23845 ENOG410880H cysteine synthase G3H79_RS23865 ENOG4105JZC GHMP kinase G3H79_RS23905 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS23910 ENOG4105C5I Dehydrogenase G3H79_RS23925 ENOG4105DEN Luciferase family G3H79_RS23930 ENOG4107RSM transcriptional regulator G3H79_RS23935 ENOG4105BZU Histidine kinase G3H79_RS23980 ENOG4105CVJ phosphoglycerate mutase G3H79_RS24005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS24010 ENOG4105BZU Histidine kinase G3H79_RS24040 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS24055 ENOG4107XI7 Tetr family transcriptional regulator G3H79_RS24065 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G3H79_RS24070 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS24090 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3H79_RS24105 ENOG4105E2D ec 3.2.1.52 G3H79_RS24115 ENOG4105DY8 decarboxylase G3H79_RS24135 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS24140 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3H79_RS24150 ENOG4107QX3 carboxylase G3H79_RS24165 ENOG4105C29 acyl-CoA thioesterase G3H79_RS24175 ENOG4108XFF G3H79_RS24185 ENOG4105CK7 Sodium proline symporter G3H79_RS24195 ENOG4105C7K acetolactate synthase G3H79_RS24225 ENOG4105D17 glycoside hydrolase, family 3 domain protein G3H79_RS24235 ENOG4108594 Permease of the drug metabolite transporter G3H79_RS24250 ENOG410645S MarR family Transcriptional regulator G3H79_RS24345 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G3H79_RS24350 ENOG4108RVA ribokinase G3H79_RS24355 ENOG4105CNN ABC, transporter G3H79_RS24360 ENOG4105C2J ABC transporter G3H79_RS24365 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS24370 ENOG4105C7H Helicase, RecD TraA family G3H79_RS24400 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G3H79_RS24405 ENOG4105D7K pfkb domain protein G3H79_RS24415 ENOG4105DH8 myo-inositol catabolism G3H79_RS24420 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G3H79_RS24425 ENOG4105C26 Dehydrogenase G3H79_RS24445 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G3H79_RS24465 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G3H79_RS24470 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G3H79_RS24475 ENOG4108IQE Amp-dependent synthetase and ligase G3H79_RS24505 ENOG4105VHU single-stranded DNA-binding protein G3H79_RS24540 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3H79_RS24570 ENOG4105CT1 (ABC) transporter G3H79_RS24585 ENOG4105F8D glycoside hydrolase family 4 G3H79_RS24590 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G3H79_RS24605 ENOG4105E2R ROK family G3H79_RS24610 ENOG4105D8X mechanosensitive ion channel G3H79_RS24635 ENOG4108ZT1 Transcriptional regulator G3H79_RS24640 ENOG4108KTG Membrane protein, drug metabolite transporter G3H79_RS24665 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3H79_RS24680 ENOG41061H0 Monooxygenase G3H79_RS24690 ENOG4107RSM transcriptional regulator G3H79_RS24695 ENOG4105F27 Major Facilitator G3H79_RS24760 ENOG4105MC2 DSBA oxidoreductase G3H79_RS24770 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3H79_RS24775 ENOG4105C85 amino acid G3H79_RS24780 ENOG4105C85 amino acid G3H79_RS24795 ENOG4105C85 amino acid G3H79_RS24820 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS24835 ENOG4108TGC Acyltransferase G3H79_RS24845 ENOG4108762 serine threonine protein kinase G3H79_RS24860 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G3H79_RS24865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3H79_RS24870 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3H79_RS24875 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G3H79_RS24900 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G3H79_RS24910 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3H79_RS24920 ENOG4105BZU Histidine kinase G3H79_RS24930 ENOG4105BZU Histidine kinase G3H79_RS24940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3H79_RS24950 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G3H79_RS24955 ENOG4105DFF Rod shape-determining protein mreb G3H79_RS24970 ENOG4107RVG penicillin-binding protein G3H79_RS24975 ENOG4105CNI cell division protein FtsW G3H79_RS25005 ENOG4105C03 ribonuclease G3H79_RS25015 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G3H79_RS25020 ENOG4105K46 50S ribosomal protein l27 G3H79_RS25025 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G3H79_RS25035 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G3H79_RS25045 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G3H79_RS25060 ENOG4105D0M Protease HtpX homolog G3H79_RS25065 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G3H79_RS25080 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3H79_RS25105 ENOG4108U8T Mannosyltransferase G3H79_RS25115 ENOG4107QIZ NADH dehydrogenase G3H79_RS25125 ENOG4105C8T Leucyl-tRNA synthetase G3H79_RS25135 ENOG4105EPR degv family G3H79_RS25140 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G3H79_RS25145 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G3H79_RS25150 ENOG4108YYC ycei family G3H79_RS25165 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) G3H79_RS25170 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G3H79_RS25180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3H79_RS25185 ENOG4105BZU Histidine kinase G3H79_RS25210 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G3H79_RS25215 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3H79_RS25220 ENOG4107QWG 2-Nitropropane dioxygenase G3H79_RS25240 ENOG4107RE3 peptidase, S41 G3H79_RS25245 ENOG4107YU2 histidine triad (hIT) protein G3H79_RS25250 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G3H79_RS25260 ENOG4105EQX glucarate dehydratase G3H79_RS25265 ENOG4107UEK pfkb domain protein G3H79_RS25275 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G3H79_RS25285 ENOG4105MSB protein, conserved in bacteria G3H79_RS25305 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G3H79_RS25320 ENOG4105D4Y metalloprotease G3H79_RS25325 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3H79_RS25335 ENOG4105EYF MMPL domain protein G3H79_RS25340 ENOG4105BZU Histidine kinase G3H79_RS25345 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS25350 ENOG4108478 ec 3.2.1.18 G3H79_RS25355 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3H79_RS25360 ENOG4108JQ7 (ABC) transporter G3H79_RS25365 ENOG4105C3U ABC transporter G3H79_RS25375 ENOG4105DEF Extracellular solute-binding protein, family 5 G3H79_RS25380 ENOG4105JXH GntR family transcriptional regulator G3H79_RS25390 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein G3H79_RS25400 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS25405 ENOG4108SC4 )-transporter G3H79_RS25450 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G3H79_RS25455 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3H79_RS25470 ENOG4105FDK ABC transporter G3H79_RS25475 ENOG4105DSE periplasmic solute binding protein G3H79_RS25480 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G3H79_RS25500 ENOG4105CPC Aldo Keto reductase G3H79_RS25510 ENOG4105C57 major facilitator superfamily G3H79_RS25545 ENOG4105E2R ROK family G3H79_RS25550 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G3H79_RS25575 ENOG4105C0X amino acid G3H79_RS25590 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3H79_RS25600 ENOG4107QZF nitrite reductase NADPH large subunit G3H79_RS25605 ENOG4108IFG nitrite reductase, (NAD(P)H) G3H79_RS25625 ENOG4108Z4X TRANSCRIPTIONal G3H79_RS25635 ENOG4108FKE two-component system sensor kinase G3H79_RS25655 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3H79_RS25665 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G3H79_RS25675 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3H79_RS25680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3H79_RS25720 ENOG4107TPY serine threonine protein kinase G3H79_RS25755 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) G3H79_RS25775 ENOG4105X1Q TOBE domain protein G3H79_RS25800 ENOG4105DFF Rod shape-determining protein mreb G3H79_RS25820 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS25835 ENOG4105CIR epoxide hydrolase G3H79_RS25845 ENOG4105D9P serine threonine protein kinase G3H79_RS25885 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G3H79_RS25920 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3H79_RS25925 ENOG4108ZHJ Organic hydroperoxide resistance protein G3H79_RS25940 ENOG4105NGS secreted protein G3H79_RS25950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3H79_RS25975 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3H79_RS25980 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS26010 ENOG4105VUF Transcriptional regulator G3H79_RS26040 ENOG4105EYW Ion transport protein G3H79_RS26045 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3H79_RS26090 ENOG4105DAX Pfam:DUF2983 G3H79_RS26110 ENOG4108UHU Aldolase G3H79_RS26180 ENOG4105NQG DoxX G3H79_RS26250 ENOG4105CSH Transporter G3H79_RS26265 ENOG4106A3M Cytochrome p-450 G3H79_RS26270 ENOG4105F2C Acetyl-CoA acetyltransferase G3H79_RS26285 ENOG4108JJB ABC transporter G3H79_RS26305 ENOG4105CHR reductase G3H79_RS26325 ENOG4108SGK Tetr family transcriptional regulator G3H79_RS26330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3H79_RS26335 ENOG4107QVI Methyltransferase, type 11 G3H79_RS26370 ENOG4105DYW oxidoreductase G3H79_RS26380 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G3H79_RS26390 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS26395 ENOG4105D2B acyl-CoA dehydrogenase G3H79_RS26410 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS26415 ENOG4105BZU Histidine kinase G3H79_RS26420 ENOG4105FQP Beta-lactamase G3H79_RS26425 ENOG4108S01 response regulator G3H79_RS26430 ENOG4105BZU Histidine kinase G3H79_RS26440 ENOG4107QPD alcohol dehydrogenase G3H79_RS26445 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3H79_RS26455 ENOG4108MES Periplasmic binding protein G3H79_RS26460 ENOG4105EGD dinuclear metal center protein, YbgI family G3H79_RS26475 ENOG4108UHU Aldolase G3H79_RS26480 ENOG4107XFJ UPF0246 protein G3H79_RS26535 ENOG4105CJ1 ABC, transporter G3H79_RS26585 ENOG4105JAB phenazine biosynthesis protein, phzf family G3H79_RS26600 ENOG4105DGI Alkaline phosphatase G3H79_RS26610 ENOG4107S1E Beta-lactamase G3H79_RS26615 ENOG4105C2C drug resistance transporter, Bcr CflA G3H79_RS26625 ENOG4105CIK Amidinotransferase G3H79_RS26650 ENOG4106A0S G3H79_RS26660 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS26665 ENOG4105EHG Permease protein G3H79_RS26670 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G3H79_RS26730 ENOG4107XZ0 Peptidase M50 G3H79_RS26750 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G3H79_RS26755 ENOG4105C57 major facilitator superfamily G3H79_RS26770 ENOG4105F27 Major Facilitator G3H79_RS26775 ENOG4105C4K Nad synthetase G3H79_RS26780 ENOG4107R16 Multicopper oxidase G3H79_RS26795 ENOG4106HB6 Alpha beta hydrolase G3H79_RS26800 ENOG41060NJ transcriptional regulator G3H79_RS26810 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G3H79_RS26840 ENOG41081JD Transcriptional regulator G3H79_RS26845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3H79_RS26850 ENOG4105C5F glutamine synthetase G3H79_RS26865 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G3H79_RS26875 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS26880 ENOG4105CG3 alpha amylase, catalytic region G3H79_RS26925 ENOG4108Z6Z Transcriptional regulator G3H79_RS26945 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS26950 ENOG4108XG2 Histidine kinase G3H79_RS26955 ENOG4107R13 MMPL domain protein G3H79_RS26965 ENOG4107NHD transcriptional regulator G3H79_RS26970 ENOG4107R5B glutamine synthetase G3H79_RS26980 ENOG4108222 arsenate reductase G3H79_RS26995 ENOG4105HDK L-asparaginase G3H79_RS27020 ENOG4105EHG Permease protein G3H79_RS27025 ENOG4105E0A ABC, transporter G3H79_RS27075 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3H79_RS27080 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G3H79_RS27105 ENOG4108Z7F N-acetyltransferase G3H79_RS27130 ENOG4105CHR reductase G3H79_RS27140 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3H79_RS27160 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G3H79_RS27165 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G3H79_RS27180 ENOG4105CRK lysyL-tRNA synthetase G3H79_RS27185 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3H79_RS27205 ENOG4105C0H protease G3H79_RS27210 ENOG4105DXX methyltransferase G3H79_RS27230 ENOG4105BZU Histidine kinase G3H79_RS27235 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS27250 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G3H79_RS27270 ENOG4107T4Z adenosine kinase G3H79_RS27280 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3H79_RS27285 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3H79_RS27290 ENOG4105MCD Part of cytochrome c oxidase, its function is G3H79_RS27295 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G3H79_RS27305 ENOG4105CCU oxidase (Subunit III) G3H79_RS27310 ENOG4107UDY cytochrome C G3H79_RS27315 ENOG4107EUI c reductase, iron-sulfur G3H79_RS27320 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3H79_RS27325 ENOG4108I0Q anthranilate phosphoribosyltransferase G3H79_RS27330 ENOG4105C9B Cysteine desulfurase G3H79_RS27335 ENOG4105BZW Glycerate kinase G3H79_RS27345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS27350 ENOG4106F60 Histidine kinase G3H79_RS27400 ENOG4105JNK Glycosyl transferase (Group 1 G3H79_RS27420 ENOG4105D0U Arsenite-activated ATPase (ArsA) G3H79_RS27430 ENOG4105DKQ ROK family G3H79_RS27460 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS27465 ENOG4105CTQ phosphohexokinase G3H79_RS27470 ENOG4105C5I Dehydrogenase G3H79_RS27495 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G3H79_RS27505 ENOG4108UQY Iron-storage protein G3H79_RS27515 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G3H79_RS27525 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G3H79_RS27540 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase G3H79_RS27550 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G3H79_RS27575 ENOG4107Z3H Transcriptional regulator, TetR family G3H79_RS27585 ENOG4105IDI abc transporter atp-binding protein G3H79_RS27595 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3H79_RS27615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3H79_RS27625 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G3H79_RS27635 ENOG4105CJN penicillin-binding protein G3H79_RS27640 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3H79_RS27650 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G3H79_RS27655 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G3H79_RS27665 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G3H79_RS27670 ENOG4105ME9 cell division protein FtsQ G3H79_RS27675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G3H79_RS27680 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G3H79_RS27685 ENOG4105DFA alanine racemase domain protein G3H79_RS27690 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G3H79_RS27705 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G3H79_RS27730 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G3H79_RS27760 ENOG4108QVN serine threonine protein kinase G3H79_RS27785 ENOG4105C0B DNA polymerase III (alpha subunit) G3H79_RS27815 ENOG4108Z66 YbaK ebsC protein G3H79_RS27835 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G3H79_RS27840 ENOG4105CIH Imidazole acetol-phosphate transaminase G3H79_RS27845 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G3H79_RS27850 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G3H79_RS27855 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G3H79_RS27860 ENOG4108176 endoribonuclease L-psp G3H79_RS27865 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G3H79_RS27890 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G3H79_RS27915 ENOG4105DK0 Indole-3-glycerol phosphate synthase G3H79_RS27925 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G3H79_RS27930 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G3H79_RS27935 ENOG4108R9S DSBA oxidoreductase G3H79_RS27940 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G3H79_RS27950 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3H79_RS27955 ENOG4108RVA ribokinase G3H79_RS27975 ENOG41065RQ ADP-ribosylation crystallin J1 G3H79_RS27985 ENOG4105CBC glutamate synthase G3H79_RS28030 ENOG41088PD hydrolase G3H79_RS28040 ENOG4105M2Z protein tyrosine serine phosphatase G3H79_RS28045 ENOG410834F Transcriptional regulator G3H79_RS28055 ENOG4105VEQ Cold shock protein G3H79_RS28060 ENOG4105C1J atp-dependent rna helicase G3H79_RS28065 ENOG4105DDN Pentapeptide repeat-containing protein G3H79_RS28075 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap G3H79_RS28080 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS28085 ENOG4105BZU Histidine kinase G3H79_RS28095 ENOG4105ESP cell wall surface anchor family protein G3H79_RS28110 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G3H79_RS28115 ENOG41063TF transcriptional regulator (AraC G3H79_RS28140 ENOG4105CGH 5'-nucleotidase G3H79_RS28155 ENOG4105EUZ Beta-lactamase domain protein G3H79_RS28175 ENOG4108IV0 ABC, transporter G3H79_RS28180 ENOG4105C0Z ABC transporter G3H79_RS28185 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3H79_RS28190 ENOG4105C32 Amino acid ABC transporter (Permease) G3H79_RS28205 ENOG4105KA0 thioesterase Superfamily protein G3H79_RS28235 ENOG4105CQ7 ATP-dependent helicase G3H79_RS28240 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS28265 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G3H79_RS28300 ENOG4105CSX c4-dicarboxylate anaerobic carrier G3H79_RS28310 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G3H79_RS28340 ENOG4105C0D helicase G3H79_RS28370 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3H79_RS28375 ENOG4106A3M Cytochrome p-450 G3H79_RS28445 ENOG4105D7N magnesium and cobalt transport protein CorA G3H79_RS28450 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS28455 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) G3H79_RS28460 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) G3H79_RS28475 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3H79_RS28480 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G3H79_RS28485 ENOG4105BZU Histidine kinase G3H79_RS28490 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G3H79_RS28515 ENOG4105CSH Transporter G3H79_RS28520 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G3H79_RS28535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3H79_RS28540 ENOG4105E39 Enoyl-CoA hydratase G3H79_RS28545 ENOG4108YYC ycei family G3H79_RS28580 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G3H79_RS28585 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G3H79_RS28590 ENOG4105CHW UPF0052 protein G3H79_RS28595 ENOG4105CIE May be required for sporulation (By similarity) G3H79_RS28605 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3H79_RS28610 ENOG4105BZA Phosphoglycerate kinase G3H79_RS28615 ENOG4105CP7 Triose-phosphate isomerase G3H79_RS28635 ENOG4107QP8 phosphohexose isomerase G3H79_RS28645 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) G3H79_RS28660 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G3H79_RS28670 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G3H79_RS28690 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) G3H79_RS28700 ENOG4105CJ1 ABC, transporter G3H79_RS28705 ENOG4105TMB Formate nitrite transporter G3H79_RS28710 ENOG4108AQF aminoglycoside N(3)-acetyltransferase G3H79_RS28725 ENOG4105JRK feS assembly protein SufD G3H79_RS28735 ENOG4105C3K feS assembly ATPase SufC G3H79_RS28740 ENOG4105C9B Cysteine desulfurase G3H79_RS28745 ENOG4108UNV SUF system FeS assembly protein, NifU family G3H79_RS28760 ENOG4108RFG Tetr family transcriptional regulator G3H79_RS28775 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) G3H79_RS28785 ENOG4105NAF rna polymerase sigma factor G3H79_RS28795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3H79_RS28890 ENOG4105CPQ Dehydrogenase G3H79_RS28895 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G3H79_RS28910 ENOG4105E98 transcriptional regulator DeoR family G3H79_RS28920 ENOG4105E9Z Nad-dependent epimerase dehydratase G3H79_RS28945 ENOG4105DRR Transcriptional regulator, GntR family G3H79_RS28950 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3H79_RS28975 ENOG4105CJN penicillin-binding protein G3H79_RS28980 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS28985 ENOG4105BZU Histidine kinase G3H79_RS28995 ENOG4107HP6 Transcriptional regulator G3H79_RS29015 ENOG4105KVH Transcriptional regulator G3H79_RS29025 ENOG4105C9B Cysteine desulfurase G3H79_RS29030 ENOG4108ZT1 Transcriptional regulator G3H79_RS29035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3H79_RS29040 ENOG4105EV8 ectoine hydroxylase G3H79_RS29045 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) G3H79_RS29050 ENOG4108JPW Aminotransferase G3H79_RS29055 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase G3H79_RS29065 ENOG4105C5R Aminotransferase G3H79_RS29075 ENOG4105CBG Sulfatase G3H79_RS29090 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G3H79_RS29095 ENOG41081F0 Precorrin-8x methylmutase G3H79_RS29100 ENOG4105E4R Precorrin-3B C17-methyltransferase G3H79_RS29110 ENOG4105CIA precorrin-4 C(11)-methyltransferase G3H79_RS29125 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G3H79_RS29130 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G3H79_RS29140 ENOG4105CTK cobaltochelatase, cobn subunit G3H79_RS29145 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G3H79_RS29150 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G3H79_RS29185 ENOG4107W7X Aldolase G3H79_RS29210 ENOG4105C5H ABC transporter G3H79_RS29230 ENOG4105VBF alkaline shock protein G3H79_RS29320 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F G3H79_RS29335 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS29345 ENOG4107QN1 sodium solute G3H79_RS29350 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3H79_RS29370 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G3H79_RS29385 ENOG4105CHR reductase G3H79_RS29390 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G3H79_RS29400 ENOG4107YCY Transcriptional regulator G3H79_RS29420 ENOG4105EAC phosphoserine phosphatase G3H79_RS29430 ENOG4105IDI abc transporter atp-binding protein G3H79_RS29440 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G3H79_RS29455 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS29475 ENOG4105DKW ABC transporter G3H79_RS29495 ENOG4108V1U phospholipid-binding protein G3H79_RS29505 ENOG4108VX5 3-methyladenine DNA glycosylase G3H79_RS29535 ENOG4105DSU hydrolase G3H79_RS29545 ENOG4105DQ5 transport system permease protein G3H79_RS29550 ENOG4105TVJ transport system, permease G3H79_RS29555 ENOG4105E0A ABC, transporter G3H79_RS29575 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3H79_RS29585 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G3H79_RS29595 ENOG4107QPH glycogen) synthase G3H79_RS29605 ENOG4105BZP glycoside hydrolase 15-related G3H79_RS29610 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G3H79_RS29615 ENOG4108YZ4 nudix hydrolase G3H79_RS29625 ENOG4105DCF alanine dehydrogenase G3H79_RS29640 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G3H79_RS29645 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G3H79_RS29650 ENOG4105FE9 pseudouridine synthase G3H79_RS29690 ENOG4105CAT Cytidine monophosphate kinase G3H79_RS29700 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G3H79_RS29715 ENOG4105MS9 Resuscitation-promoting factor G3H79_RS29720 ENOG4106839 domain protein G3H79_RS29725 ENOG4108IV0 ABC, transporter G3H79_RS29730 ENOG4105C0Z ABC transporter G3H79_RS29750 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) G3H79_RS29775 ENOG410841Q phosphoesterase PA-phosphatase related protein G3H79_RS29785 ENOG4105C57 major facilitator superfamily G3H79_RS29790 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS29795 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G3H79_RS29805 ENOG4105EAB amino acid AbC transporter G3H79_RS29810 ENOG4105E5Q amino acid AbC transporter G3H79_RS29835 ENOG4106NMR serine protease G3H79_RS29850 ENOG4107QRA Extracellular solute-binding protein, family 5 G3H79_RS29860 ENOG4108JQ6 ABC transporter G3H79_RS29870 ENOG4105C0A alcohol dehydrogenase G3H79_RS29885 ENOG4105C0B DNA polymerase III (alpha subunit) G3H79_RS29900 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G3H79_RS29910 ENOG4108MRH transcriptional regulatory protein G3H79_RS29930 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G3H79_RS29950 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS29980 ENOG4106WTF Glycosyl transferase, family 2 G3H79_RS29995 ENOG4108TCJ secreted hydrolase G3H79_RS30005 ENOG41061MD high-affinity nickel-transporter G3H79_RS30020 ENOG4105K6V RNA polymerase G3H79_RS30040 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS30050 ENOG4105C57 major facilitator superfamily G3H79_RS30065 ENOG4105F1J Homogentisate 1,2-dioxygenase G3H79_RS30070 ENOG41082JN Transcriptional regulator G3H79_RS30075 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3H79_RS30080 ENOG4105D4T Citrate transporter G3H79_RS30105 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS30120 ENOG4108Z4X TRANSCRIPTIONal G3H79_RS30165 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3H79_RS30170 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS30175 ENOG4108IG5 Transcriptional regulator G3H79_RS30205 ENOG4105VG5 Membrane G3H79_RS30210 ENOG4105PTV Nudix Hydrolase G3H79_RS30240 ENOG4105C6Z Gluconate G3H79_RS30245 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G3H79_RS30250 ENOG4105C6F GntR Family Transcriptional Regulator G3H79_RS30260 ENOG4105K5B UPF0225 protein G3H79_RS30275 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3H79_RS30300 ENOG4105C7H Helicase, RecD TraA family G3H79_RS30305 ENOG4105CPC Aldo Keto reductase G3H79_RS30310 ENOG4105DYW oxidoreductase G3H79_RS30320 ENOG4105D7N magnesium and cobalt transport protein CorA G3H79_RS30325 ENOG4108RH7 phosphoglycerate mutase G3H79_RS30340 ENOG4105C8N cysteinyl-tRNA synthetase G3H79_RS30360 ENOG4105JXH GntR family transcriptional regulator G3H79_RS30375 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3H79_RS30390 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3H79_RS30395 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3H79_RS30400 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G3H79_RS30405 ENOG4108K8U Glycerol operon regulatory protein G3H79_RS30410 ENOG4105C3R Methionine synthase G3H79_RS30415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3H79_RS30420 ENOG4105DEF Extracellular solute-binding protein, family 5 G3H79_RS30425 ENOG4108J59 Extracellular solute-binding protein, family 5 G3H79_RS30430 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS30465 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) G3H79_RS30470 ENOG4105E5F proteasome G3H79_RS30475 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) G3H79_RS30485 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G3H79_RS30490 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G3H79_RS30495 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS30505 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) G3H79_RS30540 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G3H79_RS30545 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G3H79_RS30585 ENOG4105D3G Pseudouridine synthase G3H79_RS30600 ENOG4105HFS 5'-3' exonuclease G3H79_RS30605 ENOG4108IJ7 Glycine betaine G3H79_RS30635 ENOG4108Z86 Glutamine amidotransferase G3H79_RS30640 ENOG4105CUB amino acid G3H79_RS30650 ENOG4105CFQ glutamine synthetase G3H79_RS30655 ENOG4105C26 Dehydrogenase G3H79_RS30700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G3H79_RS30705 ENOG41084BS 50S ribosomal protein L35 G3H79_RS30710 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G3H79_RS30715 ENOG4108RWN rrna methyltransferase G3H79_RS30720 ENOG4105BZU Histidine kinase G3H79_RS30725 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G3H79_RS30730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G3H79_RS30760 ENOG4105F32 YngK protein G3H79_RS30770 ENOG4105T38 integral membrane protein G3H79_RS30775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS30800 ENOG4105CPC Aldo Keto reductase G3H79_RS30805 ENOG4106JDR secreted G3H79_RS30820 ENOG4105E9K Isocitrate dehydrogenase G3H79_RS30825 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G3H79_RS30830 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G3H79_RS30835 ENOG4105CAS nag kinase G3H79_RS30840 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS30845 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) G3H79_RS30850 ENOG4105C09 Bile acid G3H79_RS30860 ENOG4105CDH Citrulline--aspartate ligase G3H79_RS30865 ENOG4105CH7 arginosuccinase G3H79_RS30880 ENOG4105C57 major facilitator superfamily G3H79_RS30885 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS30890 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G3H79_RS30920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3H79_RS30925 ENOG4108UMI ABC transporter, permease G3H79_RS30930 ENOG4105D01 (LipO)protein G3H79_RS30935 ENOG4105D01 (LipO)protein G3H79_RS30950 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3H79_RS30955 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3H79_RS31015 ENOG4105CRQ synthase (Component I) G3H79_RS31050 ENOG4105KF0 sporulation and cell division protein, SsgA G3H79_RS31075 ENOG4108IRC dna polymerase iii G3H79_RS31090 ENOG4105C22 threonyL-tRNA synthetase G3H79_RS31120 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase G3H79_RS31125 ENOG4105E2K Glycosyl transferase (Group 1 G3H79_RS31135 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G3H79_RS31140 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G3H79_RS31145 ENOG4105CDY transcriptional regulatory protein G3H79_RS31150 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G3H79_RS31155 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G3H79_RS31160 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G3H79_RS31170 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3H79_RS31175 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3H79_RS31180 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G3H79_RS31185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3H79_RS31190 ENOG4105C99 atpase involved in dna repair G3H79_RS31195 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) G3H79_RS31205 ENOG4105CUT histidyl-tRNA synthetase G3H79_RS31210 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS31215 ENOG4105BZU Histidine kinase G3H79_RS31225 ENOG4105CJ1 ABC, transporter G3H79_RS31240 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G3H79_RS31260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G3H79_RS31265 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G3H79_RS31280 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G3H79_RS31285 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G3H79_RS31290 ENOG4105D49 3-dehydroquinate synthase G3H79_RS31300 ENOG4105DC7 peptidase M24 G3H79_RS31305 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G3H79_RS31310 ENOG410803B Involved in the transcription termination process (By similarity) G3H79_RS31320 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G3H79_RS31325 ENOG4105CXT aspartate transcarbamylase G3H79_RS31330 ENOG4105CD3 dihydroorotase G3H79_RS31340 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G3H79_RS31345 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3H79_RS31350 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G3H79_RS31355 ENOG4105SKN orotidine 5''-phosphate decarboxylase G3H79_RS31365 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G3H79_RS31380 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G3H79_RS31415 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G3H79_RS31425 ENOG4105EYF MMPL domain protein G3H79_RS31430 ENOG4105DJV ribulose-phosphate 3-epimerase G3H79_RS31435 ENOG4105DKT Transcriptional regulator G3H79_RS31455 ENOG4105CUB amino acid G3H79_RS31485 ENOG4105C2W permease G3H79_RS31500 ENOG4105E2R ROK family G3H79_RS31530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3H79_RS31535 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G3H79_RS31540 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase G3H79_RS31545 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G3H79_RS31565 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS31620 ENOG4107Z3H Transcriptional regulator, TetR family G3H79_RS31630 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS31655 ENOG4105EW9 transcriptional regulator AsnC family G3H79_RS31665 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) G3H79_RS31670 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 G3H79_RS31675 ENOG4105Q70 G3H79_RS31680 ENOG4105DEU major facilitator superfamily G3H79_RS31710 ENOG4105JXB ankyrin repeat-containing protein G3H79_RS31725 ENOG4108MJN Glycosyl Transferase G3H79_RS31740 ENOG4105P4J Allophanate hydrolase, subunit 1 G3H79_RS31745 ENOG4105E7W lamb ycsf family protein G3H79_RS31750 ENOG4105CFM UPF0317 protein G3H79_RS31780 ENOG4105DVW rieske (2Fe-2S) G3H79_RS31785 ENOG4105F76 Sarcosine oxidase G3H79_RS31800 ENOG41069M3 Transcriptional regulator G3H79_RS31810 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase G3H79_RS31845 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3H79_RS31850 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G3H79_RS31855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS31865 ENOG4108UQS dipeptidase G3H79_RS31880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3H79_RS31890 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G3H79_RS31960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3H79_RS31970 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G3H79_RS32000 ENOG4107TIF Phenazine biosynthesis protein, PhzF family G3H79_RS32010 ENOG4105NTW Transcriptional regulator G3H79_RS32020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3H79_RS32050 ENOG4105CSW GntR family transcriptional regulator G3H79_RS32055 ENOG4108Q5Y Membrane G3H79_RS32060 ENOG4105JQN Transcriptional regulator G3H79_RS32100 ENOG4105CHR reductase G3H79_RS32105 ENOG4105DEF Extracellular solute-binding protein, family 5 G3H79_RS32110 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G3H79_RS32155 ENOG4107RSM transcriptional regulator G3H79_RS32195 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS32215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G3H79_RS32230 ENOG4105CHU acetyl-coa acetyltransferase G3H79_RS32245 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3H79_RS32290 ENOG4105EBR Carboxylesterase G3H79_RS32310 ENOG4108Z0R Transferase G3H79_RS32335 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3H79_RS32350 ENOG4108Z20 Acyl-transferase G3H79_RS32390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3H79_RS32395 ENOG4105EB3 Histidine kinase G3H79_RS32425 ENOG4105K4P CoA-binding domain protein G3H79_RS32460 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G3H79_RS32465 ENOG4105IDI abc transporter atp-binding protein G3H79_RS32490 ENOG4107RH8 nuclease SbcCD subunit D G3H79_RS32495 ENOG4105EYH Exonuclease G3H79_RS32515 ENOG4108PSK reductase G3H79_RS32535 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase G3H79_RS32540 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G3H79_RS32545 ENOG4108KPJ rna polymerase sigma factor G3H79_RS32555 ENOG4105FDP GntR family transcriptional regulator G3H79_RS32560 ENOG4105DKQ ROK family G3H79_RS32565 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS32570 ENOG4105BZU Histidine kinase G3H79_RS32590 ENOG4108UKI Enoyl-CoA hydratase G3H79_RS32615 ENOG4105CHR reductase G3H79_RS32620 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3H79_RS32655 ENOG4105BZU Histidine kinase G3H79_RS32660 ENOG4107T5V SNARE associated Golgi G3H79_RS32665 ENOG4105C83 adenylosuccinate lyase G3H79_RS32705 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS32725 ENOG4108R6G acetyltransferase G3H79_RS32760 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G3H79_RS32765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3H79_RS32770 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G3H79_RS32820 ENOG4108YZ9 Urea amidohydrolase subunit gamma G3H79_RS32825 ENOG4105KI2 Urea amidohydrolase subunit beta G3H79_RS32895 ENOG4108KXH Ybak prolyl-tRNA synthetase associated G3H79_RS32900 ENOG4105F6E Acyl-transferase G3H79_RS32915 ENOG4105CTQ phosphohexokinase G3H79_RS32920 ENOG4105F1K Glutamine amidotransferase G3H79_RS32930 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3H79_RS32940 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS32950 ENOG4105D44 asparaginase G3H79_RS32960 ENOG4105D3W isochorismatase G3H79_RS32970 ENOG4105EN6 Membrane G3H79_RS33010 ENOG4105CAQ asparagine synthetase G3H79_RS33020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS33030 ENOG4105EQ2 LysR family Transcriptional regulator G3H79_RS33035 ENOG4105CHP RNA polymerase G3H79_RS33070 ENOG4105EYF MMPL domain protein G3H79_RS33080 ENOG4105E2B Taurine dioxygenase G3H79_RS33105 ENOG4106KE4 Dehydrogenase G3H79_RS33130 ENOG4105EN6 Membrane G3H79_RS33160 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS33175 ENOG4108JQ1 Dehydrogenase G3H79_RS33190 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G3H79_RS33225 ENOG41082SX arsR family transcriptional regulator G3H79_RS33230 ENOG4108RYK Nad-dependent epimerase dehydratase G3H79_RS33240 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS33245 ENOG4107FKK extracellular solute-binding protein family 1 G3H79_RS33250 ENOG4105D56 permease protein G3H79_RS33255 ENOG4105EG2 ABC transporter, permease G3H79_RS33290 ENOG41065HY 1,4-beta-cellobiosidase G3H79_RS33295 ENOG4105CJQ hydrolase, family 31 G3H79_RS33300 ENOG4105NAF rna polymerase sigma factor G3H79_RS33310 ENOG4105F95 Monooxygenase G3H79_RS33335 ENOG4105VPX protein, conserved in bacteria G3H79_RS33350 ENOG4108HWW ABC transporter G3H79_RS33375 ENOG4105CXK mandelate racemase muconate lactonizing G3H79_RS33380 ENOG4107HP6 Transcriptional regulator G3H79_RS33410 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS33415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G3H79_RS33425 ENOG4105EYF MMPL domain protein G3H79_RS33435 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G3H79_RS33460 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G3H79_RS33475 ENOG4105EBR Carboxylesterase G3H79_RS33495 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G3H79_RS33500 ENOG4105CYW agmatinase G3H79_RS33510 ENOG4106ETB IIa component G3H79_RS33535 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3H79_RS33540 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3H79_RS33545 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G3H79_RS33550 ENOG4105IJJ transcriptional regulator, crp fnr family G3H79_RS33570 ENOG4105C7S Dehydrogenase G3H79_RS33575 ENOG4108JYK Dehydrogenase G3H79_RS33605 ENOG41060NJ transcriptional regulator G3H79_RS33630 ENOG4105C5R Aminotransferase G3H79_RS33635 ENOG4105CQB FAD linked oxidase domain protein G3H79_RS33660 ENOG4105C5Q Transcriptional regulator G3H79_RS33670 ENOG4105EXC Acyl-transferase G3H79_RS33675 ENOG4108KXV response regulator G3H79_RS33680 ENOG41065SU Two-component system sensor kinase G3H79_RS33735 ENOG4108Z6Z Transcriptional regulator G3H79_RS33740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3H79_RS33745 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3H79_RS33760 ENOG4105DJ2 Major Facilitator Superfamily G3H79_RS33765 ENOG4105JXH GntR family transcriptional regulator G3H79_RS33810 ENOG410841Q phosphoesterase PA-phosphatase related protein G3H79_RS33835 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G3H79_RS33885 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G3H79_RS33890 ENOG4105PSQ Acyl-transferase G3H79_RS33910 ENOG4105C10 Electron transfer flavoprotein G3H79_RS33925 ENOG4107TPY serine threonine protein kinase G3H79_RS33945 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS33965 ENOG4105EX0 alpha-galactosidase G3H79_RS33980 ENOG4105DRS transport system, permease G3H79_RS33990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3H79_RS34010 ENOG4105BZU Histidine kinase G3H79_RS34015 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS34025 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3H79_RS34030 ENOG4105BZU Histidine kinase G3H79_RS34035 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS34065 ENOG4106UW1 Major Facilitator superfamily G3H79_RS34070 ENOG4105E2R ROK family G3H79_RS34120 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS34125 ENOG4107R34 abc transporter permease protein G3H79_RS34150 ENOG4105MVE transcriptional regulator G3H79_RS34185 ENOG4107R8N Glycosyl transferase, family 2 G3H79_RS34190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3H79_RS34225 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G3H79_RS34235 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS34240 ENOG4108KPJ rna polymerase sigma factor G3H79_RS34250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3H79_RS34260 ENOG4105J0Q Transcriptional regulator G3H79_RS34265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3H79_RS34305 ENOG4105C26 Dehydrogenase G3H79_RS34330 ENOG4108UTZ Dihydroxyacetone kinase G3H79_RS34335 ENOG4105CMT Dihydroxyacetone kinase G3H79_RS34340 ENOG4105YIP Tetr family transcriptional regulator G3H79_RS34370 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS34405 ENOG4107QRI Phosphoketolase G3H79_RS34425 ENOG4105XPP Protein of unknown function (DUF1275) G3H79_RS34430 ENOG4105X7H acyl-CoA dehydrogenase G3H79_RS34435 ENOG4105CHR reductase G3H79_RS34495 ENOG4105CH2 amidohydrolase G3H79_RS34570 ENOG4105D3W isochorismatase G3H79_RS34605 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS34630 ENOG4108YYH Nadph-dependent fmn reductase G3H79_RS34695 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3H79_RS34700 ENOG4105DPX Hydrogenase, large subunit G3H79_RS34710 ENOG4107SHJ sulfite reductase subunit b G3H79_RS34735 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3H79_RS34740 ENOG4105CD5 CoA-binding domain protein G3H79_RS34745 ENOG41082MF Hydrogenase assembly chaperone hypC hupF G3H79_RS34760 ENOG4108YV4 Universal stress protein G3H79_RS34775 ENOG4109066 lysm domain bon superfamily protein G3H79_RS34805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3H79_RS34850 ENOG4107UVD Beta-phosphoglucomutase family hydrolase G3H79_RS34855 ENOG4107QRI Phosphoketolase G3H79_RS34860 ENOG4105CSR polyphosphate kinase 2 G3H79_RS34865 ENOG4107YZX Universal stress protein G3H79_RS34870 ENOG4107YZX Universal stress protein G3H79_RS34890 ENOG4105F1A Pyruvate formate-lyase G3H79_RS34895 ENOG4105C0A alcohol dehydrogenase G3H79_RS34900 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G3H79_RS34910 ENOG4107SQI penicillin amidase G3H79_RS34915 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS34925 ENOG4105EMU Dehydrogenase G3H79_RS34935 ENOG4105DND Transcriptional regulator G3H79_RS34940 ENOG4107B2H carbonic anhydrase G3H79_RS34945 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) G3H79_RS34950 ENOG4105ESN nucleotide-binding protein G3H79_RS34955 ENOG4108QZR synthase G3H79_RS34960 ENOG4108PA7 Methyltransferase G3H79_RS34965 ENOG4105WWF Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) G3H79_RS34975 ENOG4105E39 Enoyl-CoA hydratase G3H79_RS35025 ENOG4105DQ5 transport system permease protein G3H79_RS35030 ENOG4105TVJ transport system, permease G3H79_RS35035 ENOG4105E0A ABC, transporter G3H79_RS35040 ENOG4108HUF Transporter G3H79_RS35045 ENOG4105BZ1 (ABC) transporter G3H79_RS35055 ENOG4105BZ1 (ABC) transporter G3H79_RS35070 ENOG4105E93 esterase G3H79_RS35085 ENOG4105CAS nag kinase G3H79_RS35095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G3H79_RS35110 ENOG4108TKH Nitroreductase G3H79_RS35145 ENOG41089UC methyltransferase, type 11 G3H79_RS35150 ENOG41082YX Transcriptional regulator, arsr family G3H79_RS35195 ENOG4105E2R ROK family G3H79_RS35205 ENOG4105CNN ABC, transporter G3H79_RS35210 ENOG4105CNN ABC, transporter G3H79_RS35220 ENOG4107TTA Xylose isomerase domain protein TIM barrel G3H79_RS35325 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS35340 ENOG4105CJ1 ABC, transporter G3H79_RS35350 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3H79_RS35470 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G3H79_RS35490 ENOG4105EBR Carboxylesterase G3H79_RS35515 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) G3H79_RS35535 ENOG4105D8K carboxyl transferase G3H79_RS35550 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G3H79_RS35555 ENOG4105DZ1 carboxypeptidase G3H79_RS35560 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3H79_RS35565 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3H79_RS35580 ENOG4108JGH Tetr family transcriptional regulator G3H79_RS35605 ENOG4105R1U AraC Family Transcriptional Regulator G3H79_RS35620 ENOG4108V06 Glutathione peroxidase G3H79_RS35675 ENOG4105PTV Nudix Hydrolase G3H79_RS35680 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3H79_RS35685 ENOG4105BZU Histidine kinase G3H79_RS35690 ENOG4105ETX regulatoR G3H79_RS35695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G3H79_RS35710 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3H79_RS35715 ENOG4105CKI cobalamin synthesis protein G3H79_RS35720 ENOG41068HZ 50S ribosomal protein L32 G3H79_RS35735 ENOG4107TXC Transcriptional regulator G3H79_RS35750 ENOG4105CHF Glutathione S-transferase G3H79_RS35760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3H79_RS35765 ENOG4108R86 Transcriptional regulator G3H79_RS35825 ENOG4105DYW oxidoreductase G3H79_RS35840 ENOG4107RTG Major Facilitator superfamily G3H79_RS35850 ENOG4107S5I aldo keto reductase G3H79_RS35860 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) G3H79_RS35905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3H79_RS35915 ENOG4105NX3 Membrane G3H79_RS35945 ENOG4107Y2X deaminase G3H79_RS35950 ENOG4105KPY Small multidrug resistance protein G3H79_RS35980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3H79_RS35995 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G3H79_RS36010 ENOG4105E2R ROK family G3H79_RS36020 ENOG4105K56 Transcriptional regulator G3H79_RS36035 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap G3H79_RS36040 ENOG4107XI7 Tetr family transcriptional regulator G3H79_RS36070 ENOG4107RCI amp-dependent synthetase and ligase G3H79_RS36075 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS36100 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS36135 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS36145 ENOG4105IBP Cyclic peptide transporter G3H79_RS36195 ENOG4105DBV ornithine carbamoyltransferase G3H79_RS36205 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3H79_RS36220 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS36225 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS36230 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) G3H79_RS36265 ENOG4105DG4 malate L-lactate dehydrogenase G3H79_RS36335 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS36400 ENOG4105EMN RNA polymerase sigma factor G3H79_RS36420 ENOG4105BZU Histidine kinase G3H79_RS36425 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS36435 ENOG4105EYF MMPL domain protein G3H79_RS36455 ENOG410642E Short chain dehydrogenase G3H79_RS36465 ENOG4105CIR epoxide hydrolase G3H79_RS36575 ENOG4107VIJ nudix hydrolase G3H79_RS36590 ENOG4105BZ1 (ABC) transporter G3H79_RS36675 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS36780 ENOG4105VBF alkaline shock protein G3H79_RS36795 ENOG4105DZ1 carboxypeptidase G3H79_RS36800 ENOG4108FKE two-component system sensor kinase G3H79_RS36805 ENOG4108PYU two-component system response regulator G3H79_RS36835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3H79_RS36875 ENOG4105F0K SARP family transcriptional regulator G3H79_RS36970 ENOG4105EYF MMPL domain protein G3H79_RS36975 ENOG4105BZU Histidine kinase G3H79_RS36980 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS37080 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS37135 ENOG4108JQ7 (ABC) transporter G3H79_RS37155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS37165 ENOG4108K8K Transcriptional regulator G3H79_RS37200 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS37220 ENOG4105C4C beta-galactosidase G3H79_RS37230 ENOG4107MM9 BNR Asp-box repeat-containing protein G3H79_RS37240 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS37245 ENOG4105BZU Histidine kinase G3H79_RS37250 ENOG4105U5Y Transcriptional regulator G3H79_RS37265 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS37270 ENOG4105BZU Histidine kinase G3H79_RS37295 ENOG4108IND Tetr family transcriptional regulator G3H79_RS37300 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G3H79_RS37310 ENOG4108KC1 acyl-Coa dehydrogenase G3H79_RS37330 ENOG4105E98 transcriptional regulator DeoR family G3H79_RS37335 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3H79_RS37340 ENOG4105D2N Aldolase G3H79_RS37365 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS37380 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G3H79_RS37395 ENOG4105ECY inositol monophosphatase G3H79_RS37400 ENOG4105G2Y Transcriptional regulator G3H79_RS37405 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G3H79_RS37450 ENOG4105GFR rna polymerase sigma factor G3H79_RS37460 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3H79_RS37470 ENOG4105KVH Transcriptional regulator G3H79_RS37495 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G3H79_RS37505 ENOG4105CHP RNA polymerase G3H79_RS37510 ENOG4105GRZ Ycii-related protein G3H79_RS37520 ENOG4105EBR Carboxylesterase G3H79_RS37525 ENOG4107RSM transcriptional regulator G3H79_RS37535 ENOG4105EYF MMPL domain protein G3H79_RS37540 ENOG4105BZU Histidine kinase G3H79_RS37580 ENOG4105D94 Major Facilitator Superfamily G3H79_RS37605 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G3H79_RS37615 ENOG4107R9S Malate synthase G3H79_RS37635 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G3H79_RS37705 ENOG4105CIR epoxide hydrolase G3H79_RS37730 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G3H79_RS37745 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G3H79_RS37750 ENOG4105CFF transcriptional regulator G3H79_RS37760 ENOG4105CR4 methylisocitrate lyase G3H79_RS37790 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3H79_RS37795 ENOG4105CAQ asparagine synthetase G3H79_RS37800 ENOG4105EFA 4-hydroxyphenylacetate G3H79_RS37830 ENOG4105F0K SARP family transcriptional regulator G3H79_RS37875 ENOG4105BZU Histidine kinase G3H79_RS37880 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS37930 ENOG4105E8R UPF0173 metal-dependent hydrolase G3H79_RS37935 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G3H79_RS37955 ENOG4108XEP Alpha Beta Hydrolase Fold protein G3H79_RS37985 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G3H79_RS37995 ENOG4108JQ7 (ABC) transporter G3H79_RS38005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3H79_RS38010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3H79_RS38020 ENOG4107T6F Xaa-Pro aminopeptidase G3H79_RS38025 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3H79_RS38035 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein G3H79_RS38045 ENOG4105CTU Proline racemase G3H79_RS38050 ENOG4105C26 Dehydrogenase G3H79_RS38055 ENOG4105DRR Transcriptional regulator, GntR family G3H79_RS38065 ENOG4105F7P transcriptional regulator AsnC family G3H79_RS38070 ENOG4105HDK L-asparaginase G3H79_RS38145 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3H79_RS38155 ENOG4105KVH Transcriptional regulator G3H79_RS38160 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3H79_RS38180 ENOG4106YKD Cytochrome p-450 G3H79_RS38190 ENOG4105XYF acetyltransferase G3H79_RS38200 ENOG4108VGI doxx family G3H79_RS38205 ENOG4105RHY Pfam:UPF0157 G3H79_RS38220 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G3H79_RS38235 ENOG4108V5V Serine Threonine protein kinase G3H79_RS38250 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS38255 ENOG4105DU0 nucleoside hydrolase G3H79_RS38275 ENOG4108Z6Z Transcriptional regulator G3H79_RS38350 ENOG4105ED2 Beta-lactamase G3H79_RS38360 ENOG410829K Lysine exporter protein (Lyse ygga) G3H79_RS38365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS38375 ENOG4105DCG PHP domain protein G3H79_RS38380 ENOG4105C26 Dehydrogenase G3H79_RS38395 ENOG4105CSH Transporter G3H79_RS38430 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS38435 ENOG4105BZU Histidine kinase G3H79_RS38495 ENOG4105EGE secreted protein G3H79_RS38505 ENOG4106UW1 Major Facilitator superfamily G3H79_RS38535 ENOG4107WCA isomerase G3H79_RS38570 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3H79_RS38600 ENOG41086D8 Transcriptional regulator G3H79_RS38605 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS38635 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3H79_RS38665 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS38670 ENOG4106F60 Histidine kinase G3H79_RS38730 ENOG4108KB2 LysR family Transcriptional regulator G3H79_RS38770 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS38780 ENOG4105BZ1 (ABC) transporter G3H79_RS38795 ENOG4105ESN nucleotide-binding protein G3H79_RS38805 ENOG4108PA7 Methyltransferase G3H79_RS38820 ENOG4108KPJ rna polymerase sigma factor G3H79_RS38890 ENOG4105F27 Major Facilitator G3H79_RS38895 ENOG4105YVS arsR family transcriptional regulator G3H79_RS38915 ENOG4105ECQ AraC Family Transcriptional Regulator G3H79_RS38925 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G3H79_RS38940 ENOG4105KVH Transcriptional regulator G3H79_RS38955 ENOG4105CSV Glutaminase G3H79_RS38970 ENOG4107SMB hydrolase Family 5 G3H79_RS38980 ENOG4105DU6 RNA polymerase G3H79_RS38995 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) G3H79_RS39000 ENOG41090R7 Ferric uptake G3H79_RS39045 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G3H79_RS39050 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G3H79_RS39055 ENOG4107RTD sua5 ycio yrdc ywlc family protein G3H79_RS39065 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS39075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3H79_RS39080 ENOG4106F60 Histidine kinase G3H79_RS39085 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS39100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS39115 ENOG4105DMF Dehydrogenase G3H79_RS39135 ENOG4108KTG Membrane protein, drug metabolite transporter G3H79_RS39140 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS39145 ENOG4105CDH Citrulline--aspartate ligase G3H79_RS39155 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3H79_RS39160 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G3H79_RS39170 ENOG4106A3M Cytochrome p-450 G3H79_RS39190 ENOG41085A6 mbth domain-containing protein G3H79_RS39215 ENOG4108IG5 Transcriptional regulator G3H79_RS39270 ENOG4105NAE bifunctional deaminase-reductase domain protein G3H79_RS39275 ENOG4105DQE DNA ligase G3H79_RS39335 ENOG4105CEY Amp-dependent synthetase and ligase G3H79_RS39340 ENOG41061H0 Monooxygenase G3H79_RS39345 ENOG4105E1F short-chain dehydrogenase reductase G3H79_RS39365 ENOG4105EEM helicase G3H79_RS39395 ENOG4105DU1 integral membrane protein, terc G3H79_RS39410 ENOG4108R5S membrane G3H79_RS39545 ENOG4105E0A ABC, transporter G3H79_RS39550 ENOG4105J76 Periplasmic binding protein G3H79_RS39555 ENOG4105S6R Iron-hydroxamate transporter permease subunit G3H79_RS39560 ENOG4105KVH Transcriptional regulator G3H79_RS39565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3H79_RS39600 ENOG4105D4B ABC, transporter G3H79_RS39605 ENOG4105F5R ABC transporter G3H79_RS39610 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane G3H79_RS39615 ENOG4105C2J ABC transporter G3H79_RS39620 ENOG4105C9F isomerase G3H79_RS39630 ENOG4105DET Rhamnulokinase G3H79_RS39635 ENOG4105CV8 reductase G3H79_RS39660 ENOG4108WQH regulatoR G3H79_RS39730 ENOG4105DWP Membrane G3H79_RS39745 ENOG4108IGT Dipeptidase G3H79_RS39760 ENOG4105DTQ mandelate racemase muconate lactonizing G3H79_RS39770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3H79_RS39790 ENOG4105C5Q Transcriptional regulator G3H79_RS39795 ENOG4105C7B Threonine dehydratase G3H79_RS39820 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase G3H79_RS39825 ENOG4105NPE arsR family transcriptional regulator G3H79_RS39845 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS39850 ENOG4105GR3 Histidine kinase G3H79_RS39875 ENOG4105DND Transcriptional regulator G3H79_RS39905 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) G3H79_RS39910 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS39920 ENOG4105D3W isochorismatase G3H79_RS39935 ENOG4105WH1 Two component transcriptional regulator luxr family G3H79_RS39940 ENOG4105BZU Histidine kinase G3H79_RS39945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3H79_RS39970 ENOG41082BM Transcriptional regulator, arsr family G3H79_RS39995 ENOG4108HQS Glycine betaine G3H79_RS40005 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3H79_RS40015 ENOG4105ETE Transcriptional regulator (LacI family G3H79_RS40035 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G3H79_RS40070 ENOG4106NZI LysR family Transcriptional regulator G3H79_RS40080 ENOG41090B9 response to stress G3H79_RS40165 ENOG4105F44 Two component transcriptional regulator, winged helix family G3H79_RS40170 ENOG4106F60 Histidine kinase G3H79_RS40195 ENOG4105F0K SARP family transcriptional regulator G3H79_RS40205 ENOG4108HMN Caspase domain G3H79_RS40285 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3H79_RS40295 ENOG41064MX Tetr family transcriptional regulator G3H79_RS40350 ENOG4105C1G acyl-Coa dehydrogenase G3H79_RS40355 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3H79_RS40395 ENOG4108JA1 polyketide synthase G3H79_RS40420 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G3H79_RS40430 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3H79_RS40450 ENOG4105C8Y Acetylornithine aminotransferase G3H79_RS40460 ENOG4105C26 Dehydrogenase G3H79_RS40495 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3H79_RS40505 ENOG4105MXW flavin reductase domain protein, FMN-binding G3H79_RS40620 ENOG4105FDF Could be involved in DNA repair (By similarity) G3H79_RS40845 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3H79_RS40880 ENOG4107QJE Chromosome Partitioning Protein G3H79_RS40885 ENOG4105FA0 parb-like partition protein G3H79_RS40920 ENOG4105ZXU NLP P60 protein G3H79_RS40975 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G3H79_RS41130 ENOG4105C0B DNA polymerase III (alpha subunit)