locus-tag	class	description
SAVERM_RS00575	COG2205	protein histidine kinase activity
SAVERM_RS00750	COG3655	Transcriptional regulator
SAVERM_RS00795	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS00815	COG2124	cytochrome p450
SAVERM_RS00820	COG2226	methyltransferase
SAVERM_RS00860	COG0789	Transcriptional regulator
SAVERM_RS00925	COG3387	PFAM Glycoside hydrolase 15-related
SAVERM_RS00930	COG2409	Drug exporters of the RND superfamily
SAVERM_RS00940	COG0156	8-amino-7-oxononanoate synthase activity
SAVERM_RS01035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAVERM_RS01045	COG0586	Pfam SNARE associated Golgi protein
SAVERM_RS01055	COG0671	phosphoesterase, PA-phosphatase related
SAVERM_RS01065	COG2205	protein histidine kinase activity
SAVERM_RS01085	COG2205	protein histidine kinase activity
SAVERM_RS01095	COG1136	(ABC) transporter
SAVERM_RS01095	COG0577	efflux transmembrane transporter activity
SAVERM_RS01100	COG1136	(ABC) transporter
SAVERM_RS01110	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS01120	COG2267	carboxylic ester hydrolase activity
SAVERM_RS01140	COG1511	domain protein
SAVERM_RS01145	COG2409	Drug exporters of the RND superfamily
SAVERM_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS01180	COG0300	oxidoreductase activity
SAVERM_RS01185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAVERM_RS01220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SAVERM_RS01315	COG3883	PFAM NLP P60 protein
SAVERM_RS01315	COG0791	NLP P60 protein
SAVERM_RS01355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAVERM_RS01575	COG3344	reverse transcriptase
SAVERM_RS01605	COG0789	Transcriptional regulator
SAVERM_RS01660	COG1280	lysine exporter protein (LysE YggA)
SAVERM_RS01665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS01915	COG2826	transposase and inactivated derivatives, IS30 family
SAVERM_RS01930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAVERM_RS01960	COG0657	acetylesterase activity
SAVERM_RS01965	COG3328	transposase activity
SAVERM_RS02035	COG0583	DNA-binding transcription factor activity
SAVERM_RS02115	COG0640	Transcriptional regulator
SAVERM_RS02230	COG3328	transposase activity
SAVERM_RS02270	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS02280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAVERM_RS02285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAVERM_RS02315	COG3547	Transposase (IS116 IS110 IS902 family)
SAVERM_RS02330	COG3012	SEC-C Motif Domain Protein
SAVERM_RS02335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAVERM_RS02350	COG0582	viral genome integration into host DNA
SAVERM_RS02355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS02360	COG0483	inositol monophosphate 1-phosphatase activity
SAVERM_RS02385	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS02430	COG1222	aaa ATPase
SAVERM_RS02505	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAVERM_RS02505	COG1672	PFAM Archaeal ATPase
SAVERM_RS02515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SAVERM_RS02520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SAVERM_RS02570	COG2124	cytochrome p450
SAVERM_RS02580	COG0604	alcohol dehydrogenase
SAVERM_RS02600	COG0604	alcohol dehydrogenase
SAVERM_RS02600	COG3321	synthase
SAVERM_RS02625	COG2826	transposase and inactivated derivatives, IS30 family
SAVERM_RS02650	COG1595	DNA-templated transcription, initiation
SAVERM_RS02685	COG1309	transcriptional regulator
SAVERM_RS02705	COG1309	transcriptional regulator
SAVERM_RS02730	COG0202	RNA polymerase activity
SAVERM_RS02855	COG3751	2OG-Fe(II) oxygenase superfamily
SAVERM_RS02870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAVERM_RS02885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SAVERM_RS02940	COG1733	regulation of RNA biosynthetic process
SAVERM_RS02970	COG4974	Belongs to the 'phage' integrase family
SAVERM_RS02975	COG0582	viral genome integration into host DNA
SAVERM_RS03005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAVERM_RS03050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAVERM_RS03080	COG0596	Alpha beta hydrolase
SAVERM_RS03080	COG2945	thiolester hydrolase activity
SAVERM_RS03085	COG1733	regulation of RNA biosynthetic process
SAVERM_RS03140	COG1131	(ABC) transporter
SAVERM_RS03170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SAVERM_RS03185	COG0789	Transcriptional regulator
SAVERM_RS03205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAVERM_RS03220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAVERM_RS03280	COG5297	Belongs to the glycosyl hydrolase family 6
SAVERM_RS03290	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SAVERM_RS03295	COG0778	Nitroreductase
SAVERM_RS03300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAVERM_RS03320	COG0165	Argininosuccinate lyase
SAVERM_RS03370	COG2124	cytochrome p450
SAVERM_RS03370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SAVERM_RS03435	COG1522	sequence-specific DNA binding
SAVERM_RS03490	COG1120	ATPase activity
SAVERM_RS03495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAVERM_RS03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS03510	COG3433	isochorismatase activity
SAVERM_RS03510	COG1535	isochorismatase
SAVERM_RS03530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS03590	COG0596	Alpha beta hydrolase
SAVERM_RS03615	COG0583	DNA-binding transcription factor activity
SAVERM_RS03630	COG3345	alpha-galactosidase
SAVERM_RS03640	COG1609	Transcriptional regulator
SAVERM_RS03665	COG3547	Transposase (IS116 IS110 IS902 family)
SAVERM_RS03695	COG0515	serine threonine protein kinase
SAVERM_RS03695	COG2815	serine threonine protein kinase
SAVERM_RS03755	COG2226	methyltransferase
SAVERM_RS03755	COG1073	alpha beta
SAVERM_RS03770	COG2223	nitrite transmembrane transporter activity
SAVERM_RS03780	COG0667	Aldo Keto reductase
SAVERM_RS03825	COG1595	DNA-templated transcription, initiation
SAVERM_RS03830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAVERM_RS03885	COG1733	regulation of RNA biosynthetic process
SAVERM_RS03990	COG4221	oxidoreductase activity
SAVERM_RS04010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAVERM_RS04025	COG1063	alcohol dehydrogenase
SAVERM_RS04060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAVERM_RS04070	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS04085	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS04095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAVERM_RS04160	COG0583	DNA-binding transcription factor activity
SAVERM_RS04180	COG1191	sigma factor activity
SAVERM_RS04200	COG3335	DDE superfamily endonuclease
SAVERM_RS04230	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAVERM_RS04245	COG1309	transcriptional regulator
SAVERM_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS04270	COG2132	Multicopper oxidase
SAVERM_RS04275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAVERM_RS04320	COG0583	DNA-binding transcription factor activity
SAVERM_RS04355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS04425	COG2259	Doxx family
SAVERM_RS04430	COG0531	amino acid
SAVERM_RS04460	COG0137	argininosuccinate synthase activity
SAVERM_RS04495	COG1595	DNA-templated transcription, initiation
SAVERM_RS04585	COG1278	Cold shock
SAVERM_RS04595	COG3250	beta-galactosidase activity
SAVERM_RS04615	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS04620	COG0561	phosphatase activity
SAVERM_RS04625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAVERM_RS04635	COG0534	Mate efflux family protein
SAVERM_RS04640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SAVERM_RS04660	COG2022	thiamine diphosphate biosynthetic process
SAVERM_RS04665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS04675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS04700	COG1032	radical SAM domain protein
SAVERM_RS04725	COG3251	PFAM MbtH domain protein
SAVERM_RS04735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS04780	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS04800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS04805	COG2124	cytochrome p450
SAVERM_RS04835	COG0667	Aldo Keto reductase
SAVERM_RS04850	COG2267	carboxylic ester hydrolase activity
SAVERM_RS04860	COG3896	Chloramphenicol phosphotransferase-like protein
SAVERM_RS04870	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAVERM_RS04890	COG0702	epimerase
SAVERM_RS04895	COG3415	Transposase
SAVERM_RS04895	COG2801	Transposase and inactivated derivatives
SAVERM_RS04940	COG1278	Cold shock
SAVERM_RS04985	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SAVERM_RS04995	COG0667	Aldo Keto reductase
SAVERM_RS05020	COG1090	epimerase
SAVERM_RS05025	COG1595	DNA-templated transcription, initiation
SAVERM_RS05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAVERM_RS05065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SAVERM_RS05070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SAVERM_RS05075	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SAVERM_RS05085	COG0531	amino acid
SAVERM_RS05095	COG2770	Histidine kinase
SAVERM_RS05095	COG2208	phosphoserine phosphatase activity
SAVERM_RS05100	COG0596	Alpha beta hydrolase
SAVERM_RS05140	COG2197	response regulator
SAVERM_RS05145	COG4585	Histidine kinase
SAVERM_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS05195	COG2124	cytochrome p450
SAVERM_RS05200	COG0604	alcohol dehydrogenase
SAVERM_RS05200	COG3321	synthase
SAVERM_RS05215	COG1819	glycosyl
SAVERM_RS05225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SAVERM_RS05235	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SAVERM_RS05250	COG0667	Aldo Keto reductase
SAVERM_RS05260	COG0069	glutamate synthase activity
SAVERM_RS05265	COG0028	Belongs to the TPP enzyme family
SAVERM_RS05285	COG3795	YCII-related domain
SAVERM_RS05290	COG4941	Belongs to the sigma-70 factor family
SAVERM_RS05315	COG1733	regulation of RNA biosynthetic process
SAVERM_RS05335	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS05345	COG1129	ABC transporter
SAVERM_RS05350	COG1879	ABC-type sugar transport system periplasmic component
SAVERM_RS05355	COG1609	Transcriptional regulator
SAVERM_RS05395	COG2364	Membrane
SAVERM_RS05400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS05410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAVERM_RS05420	COG0714	Associated with various cellular activities
SAVERM_RS05425	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAVERM_RS05455	COG1295	ribonuclease BN
SAVERM_RS05485	COG0501	Belongs to the peptidase M48B family
SAVERM_RS05490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAVERM_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS05520	COG0517	IMP dehydrogenase activity
SAVERM_RS05525	COG2261	transglycosylase associated protein
SAVERM_RS05540	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS05555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAVERM_RS05585	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SAVERM_RS05585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS05600	COG0142	geranyltranstransferase activity
SAVERM_RS05635	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS05640	COG1175	transmembrane transport
SAVERM_RS05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAVERM_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS05680	COG0181	hydroxymethylbilane synthase activity
SAVERM_RS05710	COG3940	Belongs to the glycosyl hydrolase 43 family
SAVERM_RS05715	COG3940	Belongs to the glycosyl hydrolase 43 family
SAVERM_RS05720	COG3647	Membrane
SAVERM_RS05745	COG0667	Aldo Keto reductase
SAVERM_RS05750	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS05815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SAVERM_RS05820	COG0435	Glutathione S-transferase
SAVERM_RS05880	COG3345	alpha-galactosidase
SAVERM_RS05885	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS05890	COG1175	transmembrane transport
SAVERM_RS05900	COG1846	Transcriptional regulator
SAVERM_RS05900	COG1940	carbohydrate kinase activity
SAVERM_RS05925	COG2205	protein histidine kinase activity
SAVERM_RS05925	COG0784	Response regulator, receiver
SAVERM_RS05925	COG5002	protein histidine kinase activity
SAVERM_RS05935	COG1191	sigma factor activity
SAVERM_RS05960	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS05965	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS05970	COG2172	sigma factor antagonist activity
SAVERM_RS06045	COG2362	D-Aminopeptidase
SAVERM_RS06085	COG0477	Major facilitator Superfamily
SAVERM_RS06115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SAVERM_RS06120	COG1070	Carbohydrate kinase
SAVERM_RS06135	COG0142	geranyltranstransferase activity
SAVERM_RS06175	COG2304	oxidoreductase activity
SAVERM_RS06180	COG0328	RNA-DNA hybrid ribonuclease activity
SAVERM_RS06220	COG0740	serine-type endopeptidase activity
SAVERM_RS06225	COG0740	serine-type endopeptidase activity
SAVERM_RS06245	COG1191	sigma factor activity
SAVERM_RS06275	COG2815	serine threonine protein kinase
SAVERM_RS06275	COG0515	serine threonine protein kinase
SAVERM_RS06285	COG1716	ATPase activity
SAVERM_RS06285	COG1131	(ABC) transporter
SAVERM_RS06285	COG0842	Transport permease protein
SAVERM_RS06300	COG0667	Aldo Keto reductase
SAVERM_RS06305	COG0583	DNA-binding transcription factor activity
SAVERM_RS06315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAVERM_RS06320	COG0346	lactoylglutathione lyase activity
SAVERM_RS06340	COG2124	cytochrome p450
SAVERM_RS06345	COG0667	Aldo Keto reductase
SAVERM_RS06365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAVERM_RS06370	COG0512	Glutamine amidotransferase of anthranilate synthase
SAVERM_RS06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAVERM_RS06400	COG2353	YceI-like domain
SAVERM_RS06420	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS06460	COG4941	Belongs to the sigma-70 factor family
SAVERM_RS06480	COG0604	alcohol dehydrogenase
SAVERM_RS06480	COG3321	synthase
SAVERM_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS06485	COG3321	synthase
SAVERM_RS06485	COG0604	alcohol dehydrogenase
SAVERM_RS06500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS06510	COG0431	NADPH-dependent FMN reductase
SAVERM_RS06520	COG0583	DNA-binding transcription factor activity
SAVERM_RS06525	COG0702	epimerase
SAVERM_RS06545	COG1595	DNA-templated transcription, initiation
SAVERM_RS06550	COG1295	ribonuclease BN
SAVERM_RS06575	COG0531	amino acid
SAVERM_RS06580	COG1940	carbohydrate kinase activity
SAVERM_RS06585	COG3250	beta-galactosidase activity
SAVERM_RS06630	COG0069	glutamate synthase activity
SAVERM_RS06640	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS06705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAVERM_RS06710	COG2199	diguanylate cyclase activity
SAVERM_RS06710	COG2203	Gaf domain
SAVERM_RS06735	COG2018	Roadblock/LC7 domain
SAVERM_RS06760	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS06770	COG2070	2-Nitropropane dioxygenase
SAVERM_RS06800	COG0515	serine threonine protein kinase
SAVERM_RS06810	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS06835	COG1063	alcohol dehydrogenase
SAVERM_RS06840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SAVERM_RS06845	COG2326	polyphosphate kinase activity
SAVERM_RS06870	COG4221	oxidoreductase activity
SAVERM_RS06875	COG4585	Histidine kinase
SAVERM_RS06880	COG2197	response regulator
SAVERM_RS06895	COG2376	Dihydroxyacetone kinase
SAVERM_RS06900	COG1461	Dihydroxyacetone kinase
SAVERM_RS06930	COG1902	pentaerythritol trinitrate reductase activity
SAVERM_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAVERM_RS06935	COG2890	protein-(glutamine-N5) methyltransferase activity
SAVERM_RS06960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAVERM_RS06980	COG3458	cephalosporin-C deacetylase activity
SAVERM_RS06990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAVERM_RS06995	COG2188	Transcriptional regulator
SAVERM_RS07000	COG2226	methyltransferase
SAVERM_RS07005	COG0366	Alpha amylase catalytic
SAVERM_RS07010	COG2124	cytochrome p450
SAVERM_RS07020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SAVERM_RS07035	COG2066	Belongs to the glutaminase family
SAVERM_RS07050	COG1113	amino acid transport
SAVERM_RS07060	COG1968	undecaprenyl-diphosphatase activity
SAVERM_RS07065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAVERM_RS07070	COG1993	acr, cog1993
SAVERM_RS07075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAVERM_RS07100	COG1175	transmembrane transport
SAVERM_RS07105	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS07125	COG0277	FAD linked oxidase domain protein
SAVERM_RS07140	COG2770	Histidine kinase
SAVERM_RS07140	COG2208	phosphoserine phosphatase activity
SAVERM_RS07150	COG2897	thiosulfate sulfurtransferase activity
SAVERM_RS07165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAVERM_RS07170	COG1116	anion transmembrane transporter activity
SAVERM_RS07175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SAVERM_RS07180	COG0477	Major facilitator Superfamily
SAVERM_RS07200	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS07205	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS07210	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS07215	COG4689	acetoacetate decarboxylase
SAVERM_RS07220	COG1024	Enoyl-CoA hydratase
SAVERM_RS07225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAVERM_RS07230	COG0583	DNA-binding transcription factor activity
SAVERM_RS07240	COG0531	amino acid
SAVERM_RS07245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAVERM_RS07260	COG2910	NAD(P)H-binding
SAVERM_RS07280	COG1959	2 iron, 2 sulfur cluster binding
SAVERM_RS07290	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SAVERM_RS07295	COG3227	Zinc metalloprotease (Elastase)
SAVERM_RS07305	COG2130	NADP-dependent
SAVERM_RS07315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS07325	COG0028	Belongs to the TPP enzyme family
SAVERM_RS07335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS07340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS07350	COG2814	Major facilitator Superfamily
SAVERM_RS07355	COG1846	Transcriptional regulator
SAVERM_RS07365	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS07370	COG1309	transcriptional regulator
SAVERM_RS07375	COG1011	Hydrolase
SAVERM_RS07380	COG0183	Belongs to the thiolase family
SAVERM_RS07390	COG0277	FAD linked oxidase domain protein
SAVERM_RS07395	COG2186	Transcriptional regulator
SAVERM_RS07400	COG1335	isochorismatase
SAVERM_RS07410	COG2072	flavoprotein involved in K transport
SAVERM_RS07420	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS07420	COG2172	sigma factor antagonist activity
SAVERM_RS07420	COG2208	phosphoserine phosphatase activity
SAVERM_RS07425	COG3284	Transcriptional regulator
SAVERM_RS07445	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS07450	COG3842	ATPase activity
SAVERM_RS07455	COG3842	ATPase activity
SAVERM_RS07495	COG2186	Transcriptional regulator
SAVERM_RS07505	COG4948	Mandelate Racemase Muconate Lactonizing
SAVERM_RS07515	COG1175	transmembrane transport
SAVERM_RS07520	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS07590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAVERM_RS07630	COG1349	DNA-binding transcription factor activity
SAVERM_RS07675	COG1940	carbohydrate kinase activity
SAVERM_RS07680	COG3145	DNA-N1-methyladenine dioxygenase activity
SAVERM_RS07685	COG2813	Specifically methylates the guanine in position
SAVERM_RS07695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAVERM_RS07700	COG1349	DNA-binding transcription factor activity
SAVERM_RS07705	COG0542	response to heat
SAVERM_RS07740	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS07745	COG4209	transmembrane transport
SAVERM_RS07750	COG3458	cephalosporin-C deacetylase activity
SAVERM_RS07785	COG2197	response regulator
SAVERM_RS07790	COG4585	Histidine kinase
SAVERM_RS07815	COG0445	tRNA wobble uridine modification
SAVERM_RS07830	COG1660	Displays ATPase and GTPase activities
SAVERM_RS07840	COG3345	alpha-galactosidase
SAVERM_RS07865	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SAVERM_RS07890	COG0204	Acyl-transferase
SAVERM_RS07925	COG0584	glycerophosphoryl diester phosphodiesterase
SAVERM_RS07970	COG0671	phosphoesterase, PA-phosphatase related
SAVERM_RS07980	COG1309	transcriptional regulator
SAVERM_RS08010	COG0640	Transcriptional regulator
SAVERM_RS08015	COG1902	pentaerythritol trinitrate reductase activity
SAVERM_RS08020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS08035	COG0281	malic enzyme
SAVERM_RS08040	COG0679	Auxin Efflux Carrier
SAVERM_RS08050	COG0583	DNA-binding transcription factor activity
SAVERM_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS08085	COG1309	transcriptional regulator
SAVERM_RS08095	COG0583	DNA-binding transcription factor activity
SAVERM_RS08105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAVERM_RS08110	COG2971	BadF BadG BcrA BcrD
SAVERM_RS08120	COG2706	6-phosphogluconolactonase activity
SAVERM_RS08125	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SAVERM_RS08150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAVERM_RS08160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAVERM_RS08165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAVERM_RS08170	COG2080	2 iron, 2 sulfur cluster binding
SAVERM_RS08200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS08210	COG2267	carboxylic ester hydrolase activity
SAVERM_RS08220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS08220	COG3320	Male sterility
SAVERM_RS08225	COG3321	synthase
SAVERM_RS08225	COG0604	alcohol dehydrogenase
SAVERM_RS08230	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS08260	COG0432	Pfam Uncharacterised protein family UPF0047
SAVERM_RS08265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAVERM_RS08270	COG1116	anion transmembrane transporter activity
SAVERM_RS08280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS08285	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS08295	COG1132	(ABC) transporter
SAVERM_RS08320	COG1132	(ABC) transporter
SAVERM_RS08325	COG1132	(ABC) transporter
SAVERM_RS08335	COG0254	rRNA binding
SAVERM_RS08350	COG1946	Acyl-CoA thioesterase
SAVERM_RS08360	COG2018	Roadblock/LC7 domain
SAVERM_RS08430	COG3239	Fatty acid desaturase
SAVERM_RS08435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAVERM_RS08450	COG1053	succinate dehydrogenase
SAVERM_RS08460	COG0667	Aldo Keto reductase
SAVERM_RS08500	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS08520	COG0628	permease
SAVERM_RS08545	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS08555	COG2814	Major facilitator Superfamily
SAVERM_RS08570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SAVERM_RS08575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAVERM_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS08605	COG3959	Transketolase, thiamine diphosphate binding domain
SAVERM_RS08610	COG3958	Transketolase
SAVERM_RS08620	COG0583	DNA-binding transcription factor activity
SAVERM_RS08625	COG0156	8-amino-7-oxononanoate synthase activity
SAVERM_RS08630	COG1063	alcohol dehydrogenase
SAVERM_RS08665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS08670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAVERM_RS08680	COG2755	lipolytic protein G-D-S-L family
SAVERM_RS08700	COG2365	Tyrosine phosphatase family
SAVERM_RS08720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAVERM_RS08725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAVERM_RS08740	COG1657	PFAM Prenyltransferase squalene oxidase
SAVERM_RS08750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAVERM_RS08760	COG1562	ergosterol biosynthetic process
SAVERM_RS08765	COG1134	teichoic acid transport
SAVERM_RS08805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAVERM_RS08815	COG1024	Enoyl-CoA hydratase
SAVERM_RS08825	COG4977	sequence-specific DNA binding
SAVERM_RS08835	COG2183	response to ionizing radiation
SAVERM_RS08840	COG0488	(ABC) transporter
SAVERM_RS08860	COG2936	dipeptidyl-peptidase activity
SAVERM_RS08875	COG1113	amino acid transport
SAVERM_RS08880	COG0789	Transcriptional regulator
SAVERM_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS08890	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS08890	COG1024	Enoyl-CoA hydratase
SAVERM_RS08895	COG0183	Belongs to the thiolase family
SAVERM_RS08900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAVERM_RS08905	COG3268	Saccharopine dehydrogenase
SAVERM_RS08910	COG1515	deoxyribonuclease V activity
SAVERM_RS08935	COG0488	(ABC) transporter
SAVERM_RS08940	COG1834	amidinotransferase
SAVERM_RS08975	COG1793	dna ligase
SAVERM_RS08980	COG1470	cell adhesion involved in biofilm formation
SAVERM_RS09000	COG0183	Belongs to the thiolase family
SAVERM_RS09000	COG0183	Belongs to the thiolase family
SAVERM_RS09005	COG3485	protocatechuate 3,4-dioxygenase
SAVERM_RS09010	COG3485	protocatechuate 3,4-dioxygenase
SAVERM_RS09015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAVERM_RS09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAVERM_RS09030	COG0477	Major facilitator Superfamily
SAVERM_RS09035	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SAVERM_RS09065	COG3511	phospholipase C
SAVERM_RS09110	COG0366	Alpha amylase catalytic
SAVERM_RS09115	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS09120	COG1175	transmembrane transport
SAVERM_RS09140	COG3938	Belongs to the proline racemase family
SAVERM_RS09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS09160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS09165	COG1177	transmembrane transport
SAVERM_RS09170	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAVERM_RS09175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SAVERM_RS09180	COG3842	ATPase activity
SAVERM_RS09235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAVERM_RS09245	COG3469	chitinase activity
SAVERM_RS09260	COG1486	melibiose metabolic process
SAVERM_RS09270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS09280	COG1175	transmembrane transport
SAVERM_RS09285	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS09290	COG3250	beta-galactosidase activity
SAVERM_RS09330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAVERM_RS09345	COG0166	Belongs to the GPI family
SAVERM_RS09350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAVERM_RS09355	COG0406	alpha-ribazole phosphatase activity
SAVERM_RS09375	COG1082	Xylose isomerase domain protein TIM barrel
SAVERM_RS09375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAVERM_RS09380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAVERM_RS09390	COG0477	Major facilitator Superfamily
SAVERM_RS09395	COG3467	pyridoxamine 5'-phosphate
SAVERM_RS09405	COG0477	Major facilitator Superfamily
SAVERM_RS09450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAVERM_RS09470	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS09485	COG1183	phosphatidylcholine synthase activity
SAVERM_RS09490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAVERM_RS09500	COG2723	6-phospho-beta-galactosidase activity
SAVERM_RS09505	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS09510	COG1175	transmembrane transport
SAVERM_RS09515	COG2182	Extracellular solute-binding protein
SAVERM_RS09535	COG1595	DNA-templated transcription, initiation
SAVERM_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS09595	COG0045	succinate-CoA ligase (ADP-forming) activity
SAVERM_RS09605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAVERM_RS09615	COG2223	nitrite transmembrane transporter activity
SAVERM_RS09630	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS09635	COG1879	ABC-type sugar transport system periplasmic component
SAVERM_RS09640	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS09645	COG1129	ABC transporter
SAVERM_RS09650	COG1940	carbohydrate kinase activity
SAVERM_RS09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS09670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAVERM_RS09675	COG3383	formate dehydrogenase (NAD+) activity
SAVERM_RS09690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAVERM_RS09695	COG1335	isochorismatase
SAVERM_RS09745	COG0477	Major facilitator Superfamily
SAVERM_RS09755	COG0656	L-ascorbic acid biosynthetic process
SAVERM_RS09765	COG4221	oxidoreductase activity
SAVERM_RS09775	COG5297	Belongs to the glycosyl hydrolase family 6
SAVERM_RS09785	COG4733	cellulase activity
SAVERM_RS09785	COG5297	Belongs to the glycosyl hydrolase family 6
SAVERM_RS09800	COG3401	FG-GAP repeat protein
SAVERM_RS09805	COG2154	pterin-4-alpha-carbinolamine dehydratase
SAVERM_RS09905	COG0488	(ABC) transporter
SAVERM_RS09915	COG2226	methyltransferase
SAVERM_RS10000	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAVERM_RS10010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAVERM_RS10015	COG2362	D-Aminopeptidase
SAVERM_RS10020	COG2226	methyltransferase
SAVERM_RS10060	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS10070	COG0604	alcohol dehydrogenase
SAVERM_RS10075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS10075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS10090	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS10095	COG0688	phosphatidylethanolamine metabolic process
SAVERM_RS10105	COG1929	Belongs to the glycerate kinase type-1 family
SAVERM_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS10135	COG1271	oxidase subunit
SAVERM_RS10140	COG1294	oxidase, subunit
SAVERM_RS10145	COG3265	gluconokinase activity
SAVERM_RS10180	COG3387	PFAM Glycoside hydrolase 15-related
SAVERM_RS10195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS10195	COG0723	plastoquinol--plastocyanin reductase activity
SAVERM_RS10210	COG0483	inositol monophosphate 1-phosphatase activity
SAVERM_RS10235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAVERM_RS10240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SAVERM_RS10265	COG1953	Uracil, thiamine, allantoin
SAVERM_RS10275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAVERM_RS10290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAVERM_RS10315	COG0405	Gamma-glutamyltransferase
SAVERM_RS10325	COG2936	dipeptidyl-peptidase activity
SAVERM_RS10330	COG0765	amino acid transport
SAVERM_RS10335	COG0765	amino acid transport
SAVERM_RS10345	COG1126	abc transporter atp-binding protein
SAVERM_RS10365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAVERM_RS10370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS10380	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SAVERM_RS10400	COG0024	Methionine aminopeptidase
SAVERM_RS10420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAVERM_RS10430	COG1940	carbohydrate kinase activity
SAVERM_RS10440	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS10450	COG2188	Transcriptional regulator
SAVERM_RS10455	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS10470	COG2197	response regulator
SAVERM_RS10475	COG0667	Aldo Keto reductase
SAVERM_RS10500	COG0598	Magnesium transport protein CorA
SAVERM_RS10505	COG4266	Belongs to the allantoicase family
SAVERM_RS10510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAVERM_RS10515	COG1414	Transcriptional regulator
SAVERM_RS10530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAVERM_RS10550	COG4264	IucA IucC family
SAVERM_RS10570	COG0436	Aminotransferase
SAVERM_RS10575	COG0406	alpha-ribazole phosphatase activity
SAVERM_RS10590	COG1733	regulation of RNA biosynthetic process
SAVERM_RS10610	COG2233	PERMEase
SAVERM_RS10625	COG2351	hydroxyisourate hydrolase activity
SAVERM_RS10650	COG3622	Belongs to the hyi family
SAVERM_RS10655	COG2084	Dehydrogenase
SAVERM_RS10660	COG0753	catalase activity
SAVERM_RS10670	COG3960	tartronate-semialdehyde synthase activity
SAVERM_RS10680	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS10685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAVERM_RS10690	COG2197	response regulator
SAVERM_RS10695	COG4133	protoheme IX ABC transporter activity
SAVERM_RS10750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAVERM_RS10760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAVERM_RS10785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAVERM_RS10795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAVERM_RS10805	COG3321	synthase
SAVERM_RS10805	COG0604	alcohol dehydrogenase
SAVERM_RS10825	COG4585	Histidine kinase
SAVERM_RS10830	COG0726	polysaccharide deacetylase
SAVERM_RS10840	COG5634	Uncharacterized conserved protein (DUF2278)
SAVERM_RS10850	COG4106	trans-aconitate 2-methyltransferase activity
SAVERM_RS10860	COG2252	PERMEase
SAVERM_RS10865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAVERM_RS10880	COG3835	regulator
SAVERM_RS10895	COG1802	Transcriptional regulator
SAVERM_RS10925	COG0028	Belongs to the TPP enzyme family
SAVERM_RS10960	COG1162	GTPase activity
SAVERM_RS10985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAVERM_RS10990	COG0277	FAD linked oxidase domain protein
SAVERM_RS11005	COG1175	transmembrane transport
SAVERM_RS11010	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS11025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAVERM_RS11065	COG0596	Alpha beta hydrolase
SAVERM_RS11095	COG2040	homocysteine
SAVERM_RS11110	COG1609	Transcriptional regulator
SAVERM_RS11140	COG1917	Cupin 2, conserved barrel domain protein
SAVERM_RS11140	COG4977	sequence-specific DNA binding
SAVERM_RS11155	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS11185	COG0175	sulfate reduction
SAVERM_RS11190	COG0529	Catalyzes the synthesis of activated sulfate
SAVERM_RS11210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAVERM_RS11215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAVERM_RS11240	COG2409	Drug exporters of the RND superfamily
SAVERM_RS11305	COG0583	DNA-binding transcription factor activity
SAVERM_RS11310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAVERM_RS11340	COG3173	Aminoglycoside phosphotransferase
SAVERM_RS11435	COG5002	protein histidine kinase activity
SAVERM_RS11440	COG2018	Roadblock/LC7 domain
SAVERM_RS11455	COG1174	glycine betaine transport
SAVERM_RS11460	COG1174	glycine betaine transport
SAVERM_RS11470	COG3345	alpha-galactosidase
SAVERM_RS11515	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS11520	COG2205	protein histidine kinase activity
SAVERM_RS11535	COG0464	growth
SAVERM_RS11560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAVERM_RS11565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAVERM_RS11600	COG0330	HflC and HflK could
SAVERM_RS11630	COG3220	belongs to the UPF0276 family
SAVERM_RS11650	COG3253	May function as heme-dependent peroxidase
SAVERM_RS11655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SAVERM_RS11665	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAVERM_RS11680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SAVERM_RS11695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SAVERM_RS11705	COG0183	Belongs to the thiolase family
SAVERM_RS11710	COG1024	Enoyl-CoA hydratase
SAVERM_RS11710	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS11715	COG1442	glycosyl transferase family 8
SAVERM_RS11715	COG1216	Glycosyl transferase, family 2
SAVERM_RS11740	COG1316	TRANSCRIPTIONal
SAVERM_RS11755	COG0531	amino acid
SAVERM_RS11760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAVERM_RS11765	COG4214	carbohydrate transport
SAVERM_RS11775	COG4213	ABC transporter substrate-binding protein
SAVERM_RS11780	COG1940	carbohydrate kinase activity
SAVERM_RS11785	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS11790	COG1175	transmembrane transport
SAVERM_RS11795	COG1653	transport
SAVERM_RS11805	COG3537	Alpha-1,2-mannosidase
SAVERM_RS11820	COG2205	protein histidine kinase activity
SAVERM_RS11825	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS11830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAVERM_RS11835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAVERM_RS11845	COG0515	serine threonine protein kinase
SAVERM_RS11905	COG0477	Major facilitator Superfamily
SAVERM_RS11925	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS11950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAVERM_RS11975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS11980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS11985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS11995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAVERM_RS12000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAVERM_RS12010	COG2271	Major facilitator Superfamily
SAVERM_RS12030	COG3629	intracellular signal transduction
SAVERM_RS12040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAVERM_RS12085	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS12090	COG0529	Catalyzes the synthesis of activated sulfate
SAVERM_RS12110	COG1024	Enoyl-CoA hydratase
SAVERM_RS12120	COG0531	amino acid
SAVERM_RS12125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAVERM_RS12130	COG2235	arginine
SAVERM_RS12145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAVERM_RS12155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS12175	COG1799	cell septum assembly
SAVERM_RS12180	COG0243	molybdopterin cofactor binding
SAVERM_RS12190	COG0640	Transcriptional regulator
SAVERM_RS12195	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SAVERM_RS12330	COG0454	-acetyltransferase
SAVERM_RS12330	COG0456	acetyltransferase
SAVERM_RS12340	COG1175	transmembrane transport
SAVERM_RS12345	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS12350	COG1132	(ABC) transporter
SAVERM_RS12355	COG1132	(ABC) transporter
SAVERM_RS12360	COG0702	epimerase
SAVERM_RS12365	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAVERM_RS12375	COG3629	intracellular signal transduction
SAVERM_RS12390	COG2264	protein methyltransferase activity
SAVERM_RS12405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS12455	COG2124	cytochrome p450
SAVERM_RS12475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAVERM_RS12480	COG0531	amino acid
SAVERM_RS12485	COG0569	domain protein
SAVERM_RS12525	COG0756	dUTP diphosphatase activity
SAVERM_RS12550	COG2205	protein histidine kinase activity
SAVERM_RS12555	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS12565	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAVERM_RS12600	COG1435	thymidine kinase activity
SAVERM_RS12620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAVERM_RS12625	COG1802	Transcriptional regulator
SAVERM_RS12630	COG0739	heme binding
SAVERM_RS12640	COG0612	Peptidase, M16
SAVERM_RS12645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAVERM_RS12665	COG0372	Belongs to the citrate synthase family
SAVERM_RS12680	COG3290	protein histidine kinase activity
SAVERM_RS12685	COG4565	transcriptional regulatory protein
SAVERM_RS12695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAVERM_RS12710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS12720	COG2197	response regulator
SAVERM_RS12735	COG0187	DNA topoisomerase II activity
SAVERM_RS12750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAVERM_RS12755	COG2186	Transcriptional regulator
SAVERM_RS12795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAVERM_RS12820	COG0588	phosphoglycerate mutase activity
SAVERM_RS12835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAVERM_RS12840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAVERM_RS12845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAVERM_RS12880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAVERM_RS12890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAVERM_RS12895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAVERM_RS12905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAVERM_RS12925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAVERM_RS12940	COG2205	protein histidine kinase activity
SAVERM_RS12945	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS12950	COG1126	abc transporter atp-binding protein
SAVERM_RS12955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAVERM_RS12960	COG0765	amino acid transport
SAVERM_RS12965	COG0765	amino acid transport
SAVERM_RS12990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAVERM_RS13000	COG0628	permease
SAVERM_RS13030	COG1201	RNA secondary structure unwinding
SAVERM_RS13035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAVERM_RS13040	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS13050	COG0783	Belongs to the Dps family
SAVERM_RS13055	COG1396	sequence-specific DNA binding
SAVERM_RS13060	COG1546	Belongs to the CinA family
SAVERM_RS13060	COG1058	Belongs to the CinA family
SAVERM_RS13070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAVERM_RS13080	COG1674	ftsk spoiiie
SAVERM_RS13095	COG2208	phosphoserine phosphatase activity
SAVERM_RS13095	COG2770	Histidine kinase
SAVERM_RS13130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SAVERM_RS13135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS13140	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SAVERM_RS13160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAVERM_RS13165	COG0612	Peptidase, M16
SAVERM_RS13170	COG1185	polyribonucleotide nucleotidyltransferase activity
SAVERM_RS13175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAVERM_RS13195	COG1674	ftsk spoiiie
SAVERM_RS13225	COG1404	Belongs to the peptidase S8 family
SAVERM_RS13270	COG0455	bacterial-type flagellum organization
SAVERM_RS13290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAVERM_RS13295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAVERM_RS13305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAVERM_RS13325	COG0779	Required for maturation of 30S ribosomal subunits
SAVERM_RS13345	COG0442	prolyl-tRNA aminoacylation
SAVERM_RS13360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAVERM_RS13365	COG0750	zinc metalloprotease
SAVERM_RS13370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SAVERM_RS13380	COG0653	protein targeting
SAVERM_RS13395	COG5297	Belongs to the glycosyl hydrolase family 6
SAVERM_RS13430	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS13435	COG4209	transmembrane transport
SAVERM_RS13440	COG1653	transport
SAVERM_RS13445	COG1472	Belongs to the glycosyl hydrolase 3 family
SAVERM_RS13450	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS13480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS13485	COG1177	transmembrane transport
SAVERM_RS13495	COG3842	ATPase activity
SAVERM_RS13520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAVERM_RS13525	COG0584	glycerophosphoryl diester phosphodiesterase
SAVERM_RS13570	COG2070	2-Nitropropane dioxygenase
SAVERM_RS13595	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS13605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAVERM_RS13635	COG3842	ATPase activity
SAVERM_RS13640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SAVERM_RS13650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAVERM_RS13660	COG0575	Belongs to the CDS family
SAVERM_RS13665	COG0233	cytoplasmic translational termination
SAVERM_RS13670	COG0528	UMP kinase activity
SAVERM_RS13675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAVERM_RS13680	COG0052	Belongs to the universal ribosomal protein uS2 family
SAVERM_RS13695	COG1191	sigma factor activity
SAVERM_RS13710	COG0792	nuclease activity
SAVERM_RS13730	COG0681	Belongs to the peptidase S26 family
SAVERM_RS13735	COG0681	Belongs to the peptidase S26 family
SAVERM_RS13745	COG0335	large ribosomal subunit rRNA binding
SAVERM_RS13750	COG0336	Belongs to the RNA methyltransferase TrmD family
SAVERM_RS13755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAVERM_RS13760	COG1837	Belongs to the UPF0109 family
SAVERM_RS13765	COG0228	four-way junction DNA binding
SAVERM_RS13775	COG0442	prolyl-tRNA aminoacylation
SAVERM_RS13830	COG0477	Major facilitator Superfamily
SAVERM_RS13845	COG1254	Belongs to the acylphosphatase family
SAVERM_RS13850	COG2340	Cysteine-rich secretory protein family
SAVERM_RS13860	COG1733	regulation of RNA biosynthetic process
SAVERM_RS13870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAVERM_RS13875	COG0571	ribonuclease III activity
SAVERM_RS13880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAVERM_RS13895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAVERM_RS13900	COG0742	ribosomal rna small subunit methyltransferase
SAVERM_RS13910	COG0326	Molecular chaperone. Has ATPase activity
SAVERM_RS13920	COG1461	Dihydroxyacetone kinase
SAVERM_RS13925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAVERM_RS13945	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAVERM_RS13950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAVERM_RS13960	COG1920	GTP binding
SAVERM_RS13970	COG0776	regulation of translation
SAVERM_RS13980	COG0066	3-isopropylmalate dehydratase activity
SAVERM_RS13985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAVERM_RS13990	COG1414	Transcriptional regulator
SAVERM_RS14035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAVERM_RS14040	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAVERM_RS14050	COG5002	protein histidine kinase activity
SAVERM_RS14055	COG2018	Roadblock/LC7 domain
SAVERM_RS14075	COG2018	Roadblock/LC7 domain
SAVERM_RS14095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAVERM_RS14130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAVERM_RS14135	COG0477	Major facilitator Superfamily
SAVERM_RS14150	COG2957	Belongs to the agmatine deiminase family
SAVERM_RS14155	COG0804	urea catabolic process
SAVERM_RS14160	COG0831	urea catabolic process
SAVERM_RS14160	COG0832	Belongs to the urease beta subunit family
SAVERM_RS14165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS14170	COG0473	3-isopropylmalate dehydrogenase activity
SAVERM_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS14195	COG0506	proline dehydrogenase activity
SAVERM_RS14200	COG2508	Transcriptional regulator
SAVERM_RS14215	COG0477	Major facilitator Superfamily
SAVERM_RS14220	COG2197	response regulator
SAVERM_RS14230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAVERM_RS14235	COG0440	acetolactate synthase activity
SAVERM_RS14255	COG0667	Aldo Keto reductase
SAVERM_RS14260	COG2133	pyrroloquinoline quinone binding
SAVERM_RS14270	COG2197	response regulator
SAVERM_RS14285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAVERM_RS14290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAVERM_RS14300	COG0154	amidase activity
SAVERM_RS14305	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAVERM_RS14315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAVERM_RS14325	COG4221	oxidoreductase activity
SAVERM_RS14330	COG1611	Belongs to the LOG family
SAVERM_RS14340	COG0482	sulfurtransferase activity
SAVERM_RS14370	COG2378	regulation of single-species biofilm formation
SAVERM_RS14385	COG2860	membrane
SAVERM_RS14395	COG4608	Belongs to the ABC transporter superfamily
SAVERM_RS14400	COG0444	Belongs to the ABC transporter superfamily
SAVERM_RS14405	COG0601	transmembrane transport
SAVERM_RS14410	COG0747	negative chemotaxis
SAVERM_RS14415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAVERM_RS14435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAVERM_RS14440	COG0509	glycine decarboxylation via glycine cleavage system
SAVERM_RS14445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAVERM_RS14450	COG1760	l-serine dehydratase
SAVERM_RS14465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAVERM_RS14475	COG0789	Transcriptional regulator
SAVERM_RS14505	COG1376	ErfK ybiS ycfS ynhG family protein
SAVERM_RS14520	COG1132	(ABC) transporter
SAVERM_RS14525	COG1132	(ABC) transporter
SAVERM_RS14530	COG1132	(ABC) transporter
SAVERM_RS14535	COG1132	(ABC) transporter
SAVERM_RS14570	COG0058	SHG alpha-glucan phosphorylase activity
SAVERM_RS14580	COG0366	Alpha amylase catalytic
SAVERM_RS14590	COG3281	Trehalose synthase
SAVERM_RS14595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAVERM_RS14610	COG3118	belongs to the thioredoxin family
SAVERM_RS14610	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS14620	COG1522	sequence-specific DNA binding
SAVERM_RS14630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAVERM_RS14635	COG0477	Major facilitator Superfamily
SAVERM_RS14645	COG1301	dicarboxylic acid transport
SAVERM_RS14650	COG3290	protein histidine kinase activity
SAVERM_RS14655	COG4565	transcriptional regulatory protein
SAVERM_RS14665	COG1175	transmembrane transport
SAVERM_RS14670	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS14680	COG0205	6-phosphofructokinase activity
SAVERM_RS14685	COG0280	phosphate acetyltransferase
SAVERM_RS14685	COG0857	belongs to the CobB CobQ family
SAVERM_RS14690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAVERM_RS14725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS14725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS14765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS14845	COG0183	Belongs to the thiolase family
SAVERM_RS14865	COG1131	(ABC) transporter
SAVERM_RS14900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SAVERM_RS14915	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS14945	COG4585	Histidine kinase
SAVERM_RS14950	COG2197	response regulator
SAVERM_RS14965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAVERM_RS14970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAVERM_RS14975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAVERM_RS14980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAVERM_RS14985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAVERM_RS14990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAVERM_RS14995	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAVERM_RS15015	COG0604	alcohol dehydrogenase
SAVERM_RS15025	COG3321	synthase
SAVERM_RS15025	COG0604	alcohol dehydrogenase
SAVERM_RS15050	COG3321	synthase
SAVERM_RS15050	COG0604	alcohol dehydrogenase
SAVERM_RS15085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SAVERM_RS15105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAVERM_RS15110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAVERM_RS15120	COG2890	protein-(glutamine-N5) methyltransferase activity
SAVERM_RS15125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAVERM_RS15130	COG0254	rRNA binding
SAVERM_RS15135	COG1316	TRANSCRIPTIONal
SAVERM_RS15145	COG0083	homoserine kinase activity
SAVERM_RS15150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAVERM_RS15155	COG0460	homoserine dehydrogenase
SAVERM_RS15160	COG0019	diaminopimelate decarboxylase activity
SAVERM_RS15165	COG0018	arginyl-trna synthetase
SAVERM_RS15170	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS15215	COG0419	ATPase involved in DNA repair
SAVERM_RS15285	COG5640	endopeptidase activity
SAVERM_RS15310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS15315	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SAVERM_RS15320	COG1793	dna ligase
SAVERM_RS15320	COG3285	dna ligase
SAVERM_RS15340	COG2205	protein histidine kinase activity
SAVERM_RS15345	COG0772	Belongs to the SEDS family
SAVERM_RS15350	COG0768	penicillin binding
SAVERM_RS15375	COG3883	PFAM NLP P60 protein
SAVERM_RS15375	COG0791	NLP P60 protein
SAVERM_RS15420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAVERM_RS15445	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS15450	COG2205	protein histidine kinase activity
SAVERM_RS15455	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAVERM_RS15455	COG0567	Dehydrogenase, E1 component
SAVERM_RS15490	COG0604	alcohol dehydrogenase
SAVERM_RS15495	COG0281	malic enzyme
SAVERM_RS15510	COG1126	abc transporter atp-binding protein
SAVERM_RS15515	COG4106	trans-aconitate 2-methyltransferase activity
SAVERM_RS15540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAVERM_RS15545	COG5285	phytanoyl-CoA dioxygenase
SAVERM_RS15550	COG0477	Major facilitator Superfamily
SAVERM_RS15555	COG0300	oxidoreductase activity
SAVERM_RS15560	COG2072	flavoprotein involved in K transport
SAVERM_RS15565	COG2175	clavaminate synthase activity
SAVERM_RS15575	COG2124	cytochrome p450
SAVERM_RS15580	COG2124	cytochrome p450
SAVERM_RS15615	COG0142	geranyltranstransferase activity
SAVERM_RS15620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAVERM_RS15635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SAVERM_RS15660	COG1597	lipid kinase activity
SAVERM_RS15675	COG0363	glucosamine-6-phosphate deaminase activity
SAVERM_RS15680	COG1472	Belongs to the glycosyl hydrolase 3 family
SAVERM_RS15685	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS15690	COG1175	transmembrane transport
SAVERM_RS15695	COG2182	Extracellular solute-binding protein
SAVERM_RS15700	COG2188	Transcriptional regulator
SAVERM_RS15720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAVERM_RS15740	COG2124	cytochrome p450
SAVERM_RS15750	COG0242	peptide deformylase activity
SAVERM_RS15765	COG2199	diguanylate cyclase activity
SAVERM_RS15765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SAVERM_RS15770	COG5662	AntiSigma factor
SAVERM_RS15775	COG1595	DNA-templated transcription, initiation
SAVERM_RS15785	COG2135	peptidase activity
SAVERM_RS15795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAVERM_RS15805	COG2076	Multidrug Resistance protein
SAVERM_RS15835	COG0483	inositol monophosphate 1-phosphatase activity
SAVERM_RS15845	COG0753	catalase activity
SAVERM_RS15870	COG1615	UPF0182 protein
SAVERM_RS15880	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAVERM_RS15930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAVERM_RS15965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAVERM_RS15970	COG0210	DNA helicase
SAVERM_RS16035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAVERM_RS16040	COG0747	negative chemotaxis
SAVERM_RS16090	COG1432	Conserved Protein
SAVERM_RS16095	COG2095	MarC family integral membrane protein
SAVERM_RS16115	COG0598	Magnesium transport protein CorA
SAVERM_RS16150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAVERM_RS16165	COG1595	DNA-templated transcription, initiation
SAVERM_RS16175	COG1024	Enoyl-CoA hydratase
SAVERM_RS16180	COG2818	Glycosylase
SAVERM_RS16190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SAVERM_RS16195	COG1611	Belongs to the LOG family
SAVERM_RS16200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAVERM_RS16235	COG2197	response regulator
SAVERM_RS16240	COG4585	Histidine kinase
SAVERM_RS16250	COG1131	(ABC) transporter
SAVERM_RS16265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAVERM_RS16300	COG4608	Belongs to the ABC transporter superfamily
SAVERM_RS16310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAVERM_RS16315	COG0601	transmembrane transport
SAVERM_RS16325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAVERM_RS16330	COG4166	transmembrane transport
SAVERM_RS16340	COG0444	Belongs to the ABC transporter superfamily
SAVERM_RS16345	COG4608	Belongs to the ABC transporter superfamily
SAVERM_RS16350	COG3251	PFAM MbtH domain protein
SAVERM_RS16355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS16365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS16375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS16380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAVERM_RS16420	COG2318	DinB family
SAVERM_RS16430	COG4608	Belongs to the ABC transporter superfamily
SAVERM_RS16435	COG0444	Belongs to the ABC transporter superfamily
SAVERM_RS16440	COG0601	transmembrane transport
SAVERM_RS16445	COG4166	transmembrane transport
SAVERM_RS16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAVERM_RS16455	COG1217	gtp-binding protein TYPA
SAVERM_RS16475	COG1053	succinate dehydrogenase
SAVERM_RS16535	COG2091	lysine biosynthetic process via aminoadipic acid
SAVERM_RS16540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAVERM_RS16565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS16580	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SAVERM_RS16600	COG4115	mRNA cleavage
SAVERM_RS16605	COG2161	toxin-antitoxin pair type II binding
SAVERM_RS16610	COG0012	GTP binding
SAVERM_RS16625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SAVERM_RS16630	COG1570	exodeoxyribonuclease VII activity
SAVERM_RS16635	COG1722	exodeoxyribonuclease VII activity
SAVERM_RS16640	COG0778	Nitroreductase
SAVERM_RS16665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SAVERM_RS16665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SAVERM_RS16680	COG0114	fumarate hydratase activity
SAVERM_RS16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAVERM_RS16720	COG1136	(ABC) transporter
SAVERM_RS16735	COG0450	alkyl hydroperoxide reductase
SAVERM_RS16740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS16750	COG0741	lytic transglycosylase activity
SAVERM_RS16755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SAVERM_RS16760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAVERM_RS16780	COG2318	DinB family
SAVERM_RS16795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAVERM_RS16800	COG2885	chlorophyll binding
SAVERM_RS16820	COG2197	response regulator
SAVERM_RS16850	COG2894	cell division
SAVERM_RS16920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAVERM_RS16965	COG2610	gluconate transmembrane transporter activity
SAVERM_RS16970	COG0251	oxidation-reduction process
SAVERM_RS16975	COG1414	Transcriptional regulator
SAVERM_RS16990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SAVERM_RS17005	COG0436	Aminotransferase
SAVERM_RS17015	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SAVERM_RS17025	COG0477	Major facilitator Superfamily
SAVERM_RS17030	COG1309	transcriptional regulator
SAVERM_RS17060	COG1331	Highly conserved protein containing a thioredoxin domain
SAVERM_RS17075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SAVERM_RS17085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAVERM_RS17090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SAVERM_RS17095	COG2255	four-way junction helicase activity
SAVERM_RS17100	COG1595	DNA-templated transcription, initiation
SAVERM_RS17120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAVERM_RS17155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAVERM_RS17160	COG1064	alcohol dehydrogenase
SAVERM_RS17180	COG1595	DNA-templated transcription, initiation
SAVERM_RS17185	COG1404	Belongs to the peptidase S8 family
SAVERM_RS17190	COG1136	(ABC) transporter
SAVERM_RS17215	COG2986	histidine ammonia-lyase
SAVERM_RS17225	COG1024	Enoyl-CoA hydratase
SAVERM_RS17235	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SAVERM_RS17245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAVERM_RS17260	COG0424	maF-like protein
SAVERM_RS17270	COG4770	biotin carboxylase activity
SAVERM_RS17280	COG1349	DNA-binding transcription factor activity
SAVERM_RS17300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAVERM_RS17315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SAVERM_RS17320	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS17325	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS17340	COG1595	DNA-templated transcription, initiation
SAVERM_RS17345	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS17350	COG2205	protein histidine kinase activity
SAVERM_RS17375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAVERM_RS17385	COG0583	DNA-binding transcription factor activity
SAVERM_RS17390	COG2814	Major facilitator Superfamily
SAVERM_RS17395	COG0592	DNA-directed DNA polymerase activity
SAVERM_RS17415	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS17420	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS17425	COG3845	ABC transporter
SAVERM_RS17430	COG1744	ABC transporter substrate-binding protein PnrA-like
SAVERM_RS17435	COG1744	ABC transporter substrate-binding protein PnrA-like
SAVERM_RS17440	COG1473	amidohydrolase
SAVERM_RS17440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAVERM_RS17450	COG2089	acid synthase
SAVERM_RS17465	COG1216	Glycosyl transferase, family 2
SAVERM_RS17475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SAVERM_RS17495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS17495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS17515	COG1595	DNA-templated transcription, initiation
SAVERM_RS17555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAVERM_RS17565	COG2009	succinate dehydrogenase
SAVERM_RS17575	COG1053	succinate dehydrogenase
SAVERM_RS17625	COG1309	transcriptional regulator
SAVERM_RS17630	COG2409	Drug exporters of the RND superfamily
SAVERM_RS17635	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS17640	COG2205	protein histidine kinase activity
SAVERM_RS17645	COG1408	metallophosphoesterase
SAVERM_RS17655	COG1686	Belongs to the peptidase S11 family
SAVERM_RS17660	COG1295	ribonuclease BN
SAVERM_RS17680	COG0180	Tryptophanyl-tRNA synthetase
SAVERM_RS17690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAVERM_RS17695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAVERM_RS17700	COG0754	glutathionylspermidine amidase activity
SAVERM_RS17730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAVERM_RS17735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS17755	COG0517	IMP dehydrogenase activity
SAVERM_RS17755	COG4175	Glycine betaine
SAVERM_RS17765	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS17775	COG0039	L-malate dehydrogenase activity
SAVERM_RS17805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAVERM_RS17815	COG0138	bifunctional purine biosynthesis protein purh
SAVERM_RS17845	COG0045	succinate-CoA ligase (ADP-forming) activity
SAVERM_RS17860	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SAVERM_RS17865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SAVERM_RS17875	COG0714	Associated with various cellular activities
SAVERM_RS17890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SAVERM_RS17900	COG0739	heme binding
SAVERM_RS17935	COG2197	response regulator
SAVERM_RS17980	COG0519	Catalyzes the synthesis of GMP from XMP
SAVERM_RS17980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SAVERM_RS17985	COG2205	protein histidine kinase activity
SAVERM_RS17990	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS17995	COG3104	oligopeptide transport
SAVERM_RS18030	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS18035	COG1191	sigma factor activity
SAVERM_RS18050	COG1228	amidohydrolase
SAVERM_RS18060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAVERM_RS18065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SAVERM_RS18115	COG1174	glycine betaine transport
SAVERM_RS18140	COG2755	lipolytic protein G-D-S-L family
SAVERM_RS18145	COG0183	Belongs to the thiolase family
SAVERM_RS18180	COG2124	cytochrome p450
SAVERM_RS18190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS18195	COG0574	Belongs to the PEP-utilizing enzyme family
SAVERM_RS18195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAVERM_RS18210	COG0702	epimerase
SAVERM_RS18220	COG1136	(ABC) transporter
SAVERM_RS18225	COG0577	efflux transmembrane transporter activity
SAVERM_RS18230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAVERM_RS18235	COG1252	NADH dehydrogenase
SAVERM_RS18255	COG0148	phosphopyruvate hydratase activity
SAVERM_RS18270	COG2124	cytochrome p450
SAVERM_RS18340	COG0577	efflux transmembrane transporter activity
SAVERM_RS18345	COG1136	(ABC) transporter
SAVERM_RS18350	COG0477	Major facilitator Superfamily
SAVERM_RS18360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS18390	COG4585	Histidine kinase
SAVERM_RS18400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAVERM_RS18405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAVERM_RS18410	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SAVERM_RS18415	COG0193	aminoacyl-tRNA hydrolase activity
SAVERM_RS18425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SAVERM_RS18435	COG1309	transcriptional regulator
SAVERM_RS18445	COG4106	trans-aconitate 2-methyltransferase activity
SAVERM_RS18450	COG1846	Transcriptional regulator
SAVERM_RS18455	COG2197	response regulator
SAVERM_RS18465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAVERM_RS18515	COG0488	(ABC) transporter
SAVERM_RS18525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAVERM_RS18530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAVERM_RS18535	COG3583	domain protein
SAVERM_RS18535	COG3584	3D domain protein
SAVERM_RS18540	COG0084	hydrolase, TatD family'
SAVERM_RS18600	COG0076	glutamate decarboxylase activity
SAVERM_RS18625	COG0310	cobalt ion transport
SAVERM_RS18635	COG1122	ATPase activity
SAVERM_RS18640	COG1846	Transcriptional regulator
SAVERM_RS18645	COG1764	response to oxidative stress
SAVERM_RS18665	COG0442	prolyl-tRNA aminoacylation
SAVERM_RS18685	COG2409	Drug exporters of the RND superfamily
SAVERM_RS18695	COG0793	Belongs to the peptidase S41A family
SAVERM_RS18695	COG4946	Tricorn protease homolog
SAVERM_RS18705	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS18710	COG2267	carboxylic ester hydrolase activity
SAVERM_RS18715	COG2072	flavoprotein involved in K transport
SAVERM_RS18725	COG0708	Exodeoxyribonuclease III
SAVERM_RS18740	COG2197	response regulator
SAVERM_RS18750	COG3629	intracellular signal transduction
SAVERM_RS18750	COG3903	Transcriptional regulator
SAVERM_RS18760	COG1136	(ABC) transporter
SAVERM_RS18775	COG2091	lysine biosynthetic process via aminoadipic acid
SAVERM_RS18795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAVERM_RS18825	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS18825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SAVERM_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS18825	COG3321	synthase
SAVERM_RS18825	COG0300	oxidoreductase activity
SAVERM_RS18830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAVERM_RS18845	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS18855	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS18860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAVERM_RS18865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAVERM_RS18870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS18910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS18915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS18920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS18945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SAVERM_RS18950	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAVERM_RS18950	COG0315	cyclic pyranopterin monophosphate synthase activity
SAVERM_RS18955	COG0315	cyclic pyranopterin monophosphate synthase activity
SAVERM_RS18965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAVERM_RS18970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAVERM_RS18990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SAVERM_RS19000	COG1970	mechanosensitive ion channel activity
SAVERM_RS19010	COG3191	aminopeptidase activity
SAVERM_RS19030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAVERM_RS19030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAVERM_RS19030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAVERM_RS19040	COG1349	DNA-binding transcription factor activity
SAVERM_RS19045	COG0477	Major facilitator Superfamily
SAVERM_RS19060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAVERM_RS19065	COG1247	-acetyltransferase
SAVERM_RS19070	COG3384	dioxygenase
SAVERM_RS19075	COG1846	Transcriptional regulator
SAVERM_RS19095	COG1414	Transcriptional regulator
SAVERM_RS19100	COG1309	transcriptional regulator
SAVERM_RS19105	COG1309	transcriptional regulator
SAVERM_RS19110	COG2124	cytochrome p450
SAVERM_RS19140	COG0582	viral genome integration into host DNA
SAVERM_RS19300	COG2188	Transcriptional regulator
SAVERM_RS19325	COG2801	Transposase and inactivated derivatives
SAVERM_RS19325	COG3415	Transposase
SAVERM_RS19385	COG0667	Aldo Keto reductase
SAVERM_RS19400	COG0277	FAD linked oxidase domain protein
SAVERM_RS19405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAVERM_RS19415	COG0640	Transcriptional regulator
SAVERM_RS19425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SAVERM_RS19450	COG1522	sequence-specific DNA binding
SAVERM_RS19525	COG0386	Belongs to the glutathione peroxidase family
SAVERM_RS19540	COG1686	Belongs to the peptidase S11 family
SAVERM_RS19605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAVERM_RS19630	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SAVERM_RS19655	COG3903	Transcriptional regulator
SAVERM_RS19655	COG3629	intracellular signal transduction
SAVERM_RS19680	COG1024	Enoyl-CoA hydratase
SAVERM_RS19685	COG2267	carboxylic ester hydrolase activity
SAVERM_RS19700	COG0431	NADPH-dependent FMN reductase
SAVERM_RS19710	COG2130	NADP-dependent
SAVERM_RS19715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAVERM_RS19715	COG0515	serine threonine protein kinase
SAVERM_RS19725	COG1309	transcriptional regulator
SAVERM_RS19740	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS19760	COG0259	pyridoxamine-phosphate oxidase activity
SAVERM_RS19775	COG2072	flavoprotein involved in K transport
SAVERM_RS19785	COG1024	Enoyl-CoA hydratase
SAVERM_RS19805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SAVERM_RS19810	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS19830	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS19835	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS19845	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS19920	COG4821	SIS domain
SAVERM_RS19930	COG0259	pyridoxamine-phosphate oxidase activity
SAVERM_RS19960	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS19975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAVERM_RS19990	COG0281	malic enzyme
SAVERM_RS20000	COG1132	(ABC) transporter
SAVERM_RS20010	COG0247	lactate metabolic process
SAVERM_RS20010	COG0277	FAD linked oxidase domain protein
SAVERM_RS20045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SAVERM_RS20060	COG2226	methyltransferase
SAVERM_RS20080	COG0667	Aldo Keto reductase
SAVERM_RS20105	COG1846	Transcriptional regulator
SAVERM_RS20115	COG2252	PERMEase
SAVERM_RS20125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAVERM_RS20145	COG2814	Major facilitator Superfamily
SAVERM_RS20155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAVERM_RS20160	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAVERM_RS20165	COG1278	Cold shock
SAVERM_RS20190	COG1061	Type III restriction enzyme res subunit
SAVERM_RS20195	COG5650	phosphatidylinositol metabolic process
SAVERM_RS20205	COG3973	AAA domain
SAVERM_RS20245	COG1737	Transcriptional regulator
SAVERM_RS20250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SAVERM_RS20265	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS20285	COG0459	protein refolding
SAVERM_RS20305	COG0463	Glycosyl transferase, family 2
SAVERM_RS20325	COG2182	Extracellular solute-binding protein
SAVERM_RS20385	COG1051	belongs to the nudix hydrolase family
SAVERM_RS20430	COG0723	plastoquinol--plastocyanin reductase activity
SAVERM_RS20430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS20450	COG3842	ATPase activity
SAVERM_RS20470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAVERM_RS20475	COG0215	cysteine-tRNA ligase activity
SAVERM_RS20480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SAVERM_RS20485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAVERM_RS20490	COG1329	Transcriptional regulator
SAVERM_RS20505	COG5002	protein histidine kinase activity
SAVERM_RS20515	COG0667	Aldo Keto reductase
SAVERM_RS20520	COG2207	Transcriptional regulator
SAVERM_RS20530	COG0588	phosphoglycerate mutase activity
SAVERM_RS20540	COG4974	Belongs to the 'phage' integrase family
SAVERM_RS20585	COG1609	Transcriptional regulator
SAVERM_RS20635	COG1917	Cupin 2, conserved barrel domain protein
SAVERM_RS20635	COG2207	Transcriptional regulator
SAVERM_RS20650	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS20690	COG1902	pentaerythritol trinitrate reductase activity
SAVERM_RS20725	COG2188	Transcriptional regulator
SAVERM_RS20735	COG2186	Transcriptional regulator
SAVERM_RS20740	COG4552	Acetyltransferase involved in intracellular survival and related
SAVERM_RS20755	COG1490	D-aminoacyl-tRNA deacylase activity
SAVERM_RS20770	COG3485	protocatechuate 3,4-dioxygenase
SAVERM_RS20810	COG2897	thiosulfate sulfurtransferase activity
SAVERM_RS20835	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS20840	COG1609	Transcriptional regulator
SAVERM_RS20850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAVERM_RS20860	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS20895	COG1132	(ABC) transporter
SAVERM_RS20905	COG0737	Belongs to the 5'-nucleotidase family
SAVERM_RS20910	COG0456	acetyltransferase
SAVERM_RS20945	COG1725	Transcriptional regulator
SAVERM_RS20950	COG1131	(ABC) transporter
SAVERM_RS20965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SAVERM_RS20975	COG0406	alpha-ribazole phosphatase activity
SAVERM_RS20975	COG0494	nUDIX hydrolase
SAVERM_RS20995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAVERM_RS21000	COG0306	phosphate transporter
SAVERM_RS21010	COG1937	Protein conserved in bacteria
SAVERM_RS21025	COG0277	FAD linked oxidase domain protein
SAVERM_RS21030	COG0671	phosphoesterase, PA-phosphatase related
SAVERM_RS21035	COG1196	nuclear chromosome segregation
SAVERM_RS21035	COG0741	lytic transglycosylase activity
SAVERM_RS21035	COG0739	heme binding
SAVERM_RS21040	COG0515	serine threonine protein kinase
SAVERM_RS21040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAVERM_RS21185	COG2226	methyltransferase
SAVERM_RS21195	COG1252	NADH dehydrogenase
SAVERM_RS21220	COG0579	oxidoreductase
SAVERM_RS21225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAVERM_RS21250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAVERM_RS21250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAVERM_RS21260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAVERM_RS21315	COG1643	Atp-dependent helicase
SAVERM_RS21350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAVERM_RS21370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAVERM_RS21375	COG0047	phosphoribosylformylglycinamidine synthase activity
SAVERM_RS21380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAVERM_RS21415	COG2197	response regulator
SAVERM_RS21425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAVERM_RS21440	COG0151	Belongs to the GarS family
SAVERM_RS21475	COG1278	Cold shock
SAVERM_RS21480	COG0513	Belongs to the DEAD box helicase family
SAVERM_RS21495	COG2972	Histidine kinase
SAVERM_RS21495	COG2205	protein histidine kinase activity
SAVERM_RS21535	COG1276	copper resistance
SAVERM_RS21535	COG2372	response to copper ion
SAVERM_RS21540	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS21575	COG0433	COG0433 Predicted ATPase
SAVERM_RS21590	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAVERM_RS21640	COG1191	sigma factor activity
SAVERM_RS21645	COG1191	sigma factor activity
SAVERM_RS21670	COG2353	YceI-like domain
SAVERM_RS21675	COG3467	pyridoxamine 5'-phosphate
SAVERM_RS21685	COG0477	Major facilitator Superfamily
SAVERM_RS21690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAVERM_RS21700	COG2205	protein histidine kinase activity
SAVERM_RS21705	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS21715	COG2329	Antibiotic biosynthesis monooxygenase
SAVERM_RS21750	COG0784	Response regulator, receiver
SAVERM_RS21755	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS21760	COG1595	DNA-templated transcription, initiation
SAVERM_RS21785	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS21840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAVERM_RS21855	COG0653	protein targeting
SAVERM_RS21875	COG0006	proline dipeptidase activity
SAVERM_RS21900	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SAVERM_RS21920	COG1999	signal sequence binding
SAVERM_RS21935	COG2837	iron assimilation
SAVERM_RS21945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAVERM_RS21950	COG0561	phosphatase activity
SAVERM_RS22000	COG0789	Transcriptional regulator
SAVERM_RS22010	COG0561	phosphatase activity
SAVERM_RS22020	COG4988	ABC transporter
SAVERM_RS22025	COG1294	oxidase, subunit
SAVERM_RS22030	COG1271	oxidase subunit
SAVERM_RS22035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS22040	COG1609	Transcriptional regulator
SAVERM_RS22055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SAVERM_RS22080	COG0662	Cupin 2, conserved barrel domain protein
SAVERM_RS22085	COG1950	PFAM Membrane protein of
SAVERM_RS22090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAVERM_RS22095	COG0626	cystathionine gamma-synthase activity
SAVERM_RS22130	COG2814	Major facilitator Superfamily
SAVERM_RS22150	COG0305	Participates in initiation and elongation during chromosome replication
SAVERM_RS22160	COG0359	binds to the 23S rRNA
SAVERM_RS22165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAVERM_RS22170	COG0629	single-stranded DNA binding
SAVERM_RS22175	COG0360	Binds together with S18 to 16S ribosomal RNA
SAVERM_RS22200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAVERM_RS22225	COG0617	tRNA 3'-terminal CCA addition
SAVERM_RS22245	COG1595	DNA-templated transcription, initiation
SAVERM_RS22255	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS22260	COG3118	belongs to the thioredoxin family
SAVERM_RS22275	COG1192	Involved in chromosome partitioning
SAVERM_RS22280	COG0357	Ribosomal RNA small subunit methyltransferase G
SAVERM_RS22290	COG0706	membrane insertase activity
SAVERM_RS22295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAVERM_RS22305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAVERM_RS22310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAVERM_RS22315	COG0592	DNA-directed DNA polymerase activity
SAVERM_RS22320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SAVERM_RS22325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAVERM_RS22330	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SAVERM_RS22335	COG0187	DNA topoisomerase II activity
SAVERM_RS22340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAVERM_RS22365	COG0515	serine threonine protein kinase
SAVERM_RS22390	COG0705	Rhomboid family
SAVERM_RS22405	COG3764	Sortase (surface protein transpeptidase)
SAVERM_RS22420	COG3764	Sortase (surface protein transpeptidase)
SAVERM_RS22425	COG3764	Sortase (surface protein transpeptidase)
SAVERM_RS22430	COG0515	serine threonine protein kinase
SAVERM_RS22450	COG1716	ATPase activity
SAVERM_RS22455	COG1716	ATPase activity
SAVERM_RS22465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAVERM_RS22470	COG1733	regulation of RNA biosynthetic process
SAVERM_RS22495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAVERM_RS22500	COG2151	metal-sulfur cluster biosynthetic enzyme
SAVERM_RS22505	COG3396	Phenylacetate-CoA oxygenase
SAVERM_RS22510	COG3460	Phenylacetate-CoA oxygenase
SAVERM_RS22515	COG3396	Phenylacetate-CoA oxygenase
SAVERM_RS22540	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAVERM_RS22545	COG1309	transcriptional regulator
SAVERM_RS22550	COG1522	sequence-specific DNA binding
SAVERM_RS22575	COG0303	'Molybdopterin
SAVERM_RS22585	COG0604	alcohol dehydrogenase
SAVERM_RS22585	COG3321	synthase
SAVERM_RS22585	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS22600	COG0515	serine threonine protein kinase
SAVERM_RS22605	COG0515	serine threonine protein kinase
SAVERM_RS22630	COG0022	dehydrogenase e1 component
SAVERM_RS22635	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAVERM_RS22685	COG1362	aminopeptidase activity
SAVERM_RS22690	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS22700	COG1741	Belongs to the pirin family
SAVERM_RS22715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAVERM_RS22760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAVERM_RS22775	COG0583	DNA-binding transcription factor activity
SAVERM_RS22785	COG1289	transmembrane transporter activity
SAVERM_RS22795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAVERM_RS22820	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS22825	COG5002	protein histidine kinase activity
SAVERM_RS22850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAVERM_RS22880	COG0222	ribosome binding
SAVERM_RS22925	COG0701	Predicted permease
SAVERM_RS22960	COG0513	Belongs to the DEAD box helicase family
SAVERM_RS22965	COG1278	Cold shock
SAVERM_RS22995	COG4585	Histidine kinase
SAVERM_RS23000	COG2197	response regulator
SAVERM_RS23060	COG0717	Belongs to the dCTP deaminase family
SAVERM_RS23065	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SAVERM_RS23075	COG2226	methyltransferase
SAVERM_RS23150	COG2181	nitrate reductase activity
SAVERM_RS23150	COG0247	lactate metabolic process
SAVERM_RS23155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAVERM_RS23160	COG0443	Heat shock 70 kDa protein
SAVERM_RS23165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAVERM_RS23170	COG0484	heat shock protein binding
SAVERM_RS23175	COG0789	Transcriptional regulator
SAVERM_RS23180	COG4213	ABC transporter substrate-binding protein
SAVERM_RS23315	COG0542	response to heat
SAVERM_RS23345	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAVERM_RS23360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAVERM_RS23365	COG0191	fructose-bisphosphate aldolase activity
SAVERM_RS23370	COG0477	Major facilitator Superfamily
SAVERM_RS23380	COG3483	tryptophan 2,3-dioxygenase activity
SAVERM_RS23385	COG3844	kynureninase activity
SAVERM_RS23420	COG4585	Histidine kinase
SAVERM_RS23425	COG2197	response regulator
SAVERM_RS23430	COG4585	Histidine kinase
SAVERM_RS23435	COG2197	response regulator
SAVERM_RS23460	COG3559	Exporter of polyketide antibiotics
SAVERM_RS23465	COG1131	(ABC) transporter
SAVERM_RS23480	COG4303	Ethanolamine ammonia lyase large subunit
SAVERM_RS23495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAVERM_RS23505	COG0463	Glycosyl transferase, family 2
SAVERM_RS23510	COG1802	Transcriptional regulator
SAVERM_RS23515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS23520	COG0693	protein deglycase activity
SAVERM_RS23540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAVERM_RS23545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAVERM_RS23600	COG0701	Predicted permease
SAVERM_RS23630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAVERM_RS23670	COG1408	metallophosphoesterase
SAVERM_RS23690	COG0003	Pfam Anion-transporting ATPase
SAVERM_RS23710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAVERM_RS23740	COG2267	carboxylic ester hydrolase activity
SAVERM_RS23750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAVERM_RS23755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAVERM_RS23815	COG1205	dead DEAH box helicase
SAVERM_RS23815	COG1111	helicase
SAVERM_RS23820	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS23825	COG2172	sigma factor antagonist activity
SAVERM_RS23830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SAVERM_RS23840	COG2890	protein-(glutamine-N5) methyltransferase activity
SAVERM_RS23855	COG1754	DNA topoisomerase type I activity
SAVERM_RS23855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAVERM_RS23860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAVERM_RS23865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SAVERM_RS23935	COG3629	intracellular signal transduction
SAVERM_RS23935	COG3903	Transcriptional regulator
SAVERM_RS23940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAVERM_RS23940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAVERM_RS23965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAVERM_RS23970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAVERM_RS23975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAVERM_RS23980	COG0254	rRNA binding
SAVERM_RS23990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAVERM_RS24010	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS24015	COG2318	DinB family
SAVERM_RS24035	COG0076	glutamate decarboxylase activity
SAVERM_RS24045	COG0789	Transcriptional regulator
SAVERM_RS24050	COG0393	Putative heavy-metal-binding
SAVERM_RS24055	COG0586	Pfam SNARE associated Golgi protein
SAVERM_RS24065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SAVERM_RS24070	COG2027	D-alanyl-D-alanine carboxypeptidase
SAVERM_RS24080	COG0037	tRNA processing
SAVERM_RS24095	COG0302	gtp cyclohydrolase
SAVERM_RS24110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SAVERM_RS24125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SAVERM_RS24125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAVERM_RS24150	COG0649	NAD binding
SAVERM_RS24165	COG2197	response regulator
SAVERM_RS24170	COG1660	Displays ATPase and GTPase activities
SAVERM_RS24195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SAVERM_RS24200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAVERM_RS24210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SAVERM_RS24230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAVERM_RS24260	COG0739	heme binding
SAVERM_RS24275	COG2205	protein histidine kinase activity
SAVERM_RS24280	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS24290	COG1595	DNA-templated transcription, initiation
SAVERM_RS24305	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SAVERM_RS24325	COG0248	Ppx GppA phosphatase
SAVERM_RS24330	COG1082	Xylose isomerase domain protein TIM barrel
SAVERM_RS24340	COG0129	dihydroxy-acid dehydratase activity
SAVERM_RS24345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAVERM_RS24345	COG0515	serine threonine protein kinase
SAVERM_RS24350	COG4991	sh3 domain protein
SAVERM_RS24365	COG0659	secondary active sulfate transmembrane transporter activity
SAVERM_RS24370	COG0842	Transport permease protein
SAVERM_RS24370	COG1129	ABC transporter
SAVERM_RS24380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SAVERM_RS24385	COG0180	Tryptophanyl-tRNA synthetase
SAVERM_RS24410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SAVERM_RS24425	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAVERM_RS24470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SAVERM_RS24475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SAVERM_RS24480	COG0181	hydroxymethylbilane synthase activity
SAVERM_RS24485	COG1648	precorrin-2 dehydrogenase activity
SAVERM_RS24485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAVERM_RS24490	COG0113	porphobilinogen synthase activity
SAVERM_RS24520	COG0018	arginyl-trna synthetase
SAVERM_RS24525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SAVERM_RS24545	COG1690	Belongs to the RtcB family
SAVERM_RS24560	COG1742	UPF0060 membrane protein
SAVERM_RS24565	COG1846	Transcriptional regulator
SAVERM_RS24570	COG1733	regulation of RNA biosynthetic process
SAVERM_RS24580	COG0477	Major facilitator Superfamily
SAVERM_RS24595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS24615	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS24620	COG2205	protein histidine kinase activity
SAVERM_RS24650	COG0531	amino acid
SAVERM_RS24660	COG1278	Cold shock
SAVERM_RS24675	COG0596	Alpha beta hydrolase
SAVERM_RS24685	COG0702	epimerase
SAVERM_RS24735	COG0697	spore germination
SAVERM_RS24750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SAVERM_RS24755	COG0406	alpha-ribazole phosphatase activity
SAVERM_RS24770	COG0785	Cytochrome C biogenesis protein
SAVERM_RS24775	COG1333	cytochrome c biogenesis protein
SAVERM_RS24780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAVERM_RS24820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SAVERM_RS24830	COG0163	prenyltransferase activity
SAVERM_RS24840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAVERM_RS24855	COG1309	transcriptional regulator
SAVERM_RS24875	COG1278	Cold shock
SAVERM_RS24880	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SAVERM_RS24900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SAVERM_RS24910	COG3979	chitinase
SAVERM_RS24930	COG2226	methyltransferase
SAVERM_RS24955	COG0791	NLP P60 protein
SAVERM_RS24955	COG1388	LysM domain
SAVERM_RS24955	COG3103	Sh3 type 3 domain protein
SAVERM_RS24965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS24970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS24975	COG0649	NAD binding
SAVERM_RS24985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAVERM_RS24990	COG1034	ATP synthesis coupled electron transport
SAVERM_RS24995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAVERM_RS25000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS25010	COG0713	ATP synthesis coupled electron transport
SAVERM_RS25015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SAVERM_RS25025	COG1007	ATP synthesis coupled electron transport
SAVERM_RS25040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SAVERM_RS25045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SAVERM_RS25050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAVERM_RS25065	COG2188	Transcriptional regulator
SAVERM_RS25080	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS25085	COG0561	phosphatase activity
SAVERM_RS25100	COG0142	geranyltranstransferase activity
SAVERM_RS25115	COG1131	(ABC) transporter
SAVERM_RS25150	COG0702	epimerase
SAVERM_RS25155	COG1733	regulation of RNA biosynthetic process
SAVERM_RS25160	COG1013	pyruvate-flavodoxin oxidoreductase activity
SAVERM_RS25165	COG0674	pyruvate-flavodoxin oxidoreductase activity
SAVERM_RS25165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SAVERM_RS25185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS25190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS25195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS25200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAVERM_RS25205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS25210	COG0839	Belongs to the complex I subunit 6 family
SAVERM_RS25215	COG0713	ATP synthesis coupled electron transport
SAVERM_RS25230	COG1007	ATP synthesis coupled electron transport
SAVERM_RS25235	COG0501	Belongs to the peptidase M48B family
SAVERM_RS25240	COG3304	Inner membrane component domain
SAVERM_RS25255	COG2261	transglycosylase associated protein
SAVERM_RS25260	COG1666	GTP binding
SAVERM_RS25270	COG1473	amidohydrolase
SAVERM_RS25275	COG0702	epimerase
SAVERM_RS25295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAVERM_RS25300	COG2030	dehydratase
SAVERM_RS25320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAVERM_RS25325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAVERM_RS25330	COG0436	Aminotransferase
SAVERM_RS25350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAVERM_RS25355	COG0081	regulation of translation
SAVERM_RS25360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAVERM_RS25365	COG0222	ribosome binding
SAVERM_RS25370	COG0085	RNA polymerase activity
SAVERM_RS25375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAVERM_RS25385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAVERM_RS25390	COG0049	tRNA binding
SAVERM_RS25395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAVERM_RS25400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAVERM_RS25420	COG0051	transcription antitermination factor activity, RNA binding
SAVERM_RS25425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAVERM_RS25430	COG0088	Forms part of the polypeptide exit tunnel
SAVERM_RS25435	COG0089	rRNA binding
SAVERM_RS25440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAVERM_RS25445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAVERM_RS25450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAVERM_RS25455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAVERM_RS25460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAVERM_RS25465	COG0255	Belongs to the universal ribosomal protein uL29 family
SAVERM_RS25470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAVERM_RS25475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAVERM_RS25480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAVERM_RS25485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAVERM_RS25490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAVERM_RS25495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAVERM_RS25500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAVERM_RS25505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAVERM_RS25510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAVERM_RS25515	COG1841	ribosomal large subunit assembly
SAVERM_RS25520	COG0200	Binds to the 23S rRNA
SAVERM_RS25530	COG0563	adenylate kinase activity
SAVERM_RS25540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAVERM_RS25545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAVERM_RS25550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAVERM_RS25555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAVERM_RS25560	COG0202	RNA polymerase activity
SAVERM_RS25565	COG0203	ribosomal protein L17
SAVERM_RS25570	COG0101	tRNA pseudouridine synthase activity
SAVERM_RS25580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAVERM_RS25585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAVERM_RS25590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAVERM_RS25600	COG1072	(Pantothenic acid kinase))
SAVERM_RS25610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAVERM_RS25615	COG0736	holo-[acyl-carrier-protein] synthase activity
SAVERM_RS25630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAVERM_RS25640	COG0802	atpase or kinase
SAVERM_RS25660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAVERM_RS25680	COG1609	Transcriptional regulator
SAVERM_RS25695	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS25700	COG1472	Belongs to the glycosyl hydrolase 3 family
SAVERM_RS25705	COG1609	Transcriptional regulator
SAVERM_RS25725	COG4941	Belongs to the sigma-70 factor family
SAVERM_RS25735	COG0726	polysaccharide deacetylase
SAVERM_RS25740	COG0726	polysaccharide deacetylase
SAVERM_RS25745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAVERM_RS25750	COG0459	protein refolding
SAVERM_RS25760	COG4221	oxidoreductase activity
SAVERM_RS25770	COG0583	DNA-binding transcription factor activity
SAVERM_RS25780	COG2197	response regulator
SAVERM_RS25785	COG1595	DNA-templated transcription, initiation
SAVERM_RS25795	COG0516	GMP reductase activity
SAVERM_RS25805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAVERM_RS25820	COG2815	serine threonine protein kinase
SAVERM_RS25820	COG0515	serine threonine protein kinase
SAVERM_RS25825	COG0515	serine threonine protein kinase
SAVERM_RS25835	COG0515	serine threonine protein kinase
SAVERM_RS25870	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS25915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAVERM_RS25920	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS25930	COG1316	TRANSCRIPTIONal
SAVERM_RS25940	COG1316	TRANSCRIPTIONal
SAVERM_RS25950	COG1316	TRANSCRIPTIONal
SAVERM_RS25955	COG1316	TRANSCRIPTIONal
SAVERM_RS25960	COG1316	TRANSCRIPTIONal
SAVERM_RS25985	COG0778	Nitroreductase
SAVERM_RS25985	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SAVERM_RS25990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAVERM_RS26025	COG1620	l-lactate permease
SAVERM_RS26030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAVERM_RS26040	COG1482	cell wall glycoprotein biosynthetic process
SAVERM_RS26050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SAVERM_RS26095	COG0714	Associated with various cellular activities
SAVERM_RS26120	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS26125	COG5002	protein histidine kinase activity
SAVERM_RS26130	COG0823	Involved in the tonB-independent uptake of proteins
SAVERM_RS26140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SAVERM_RS26145	COG2197	response regulator
SAVERM_RS26150	COG3214	Protein conserved in bacteria
SAVERM_RS26160	COG0653	protein targeting
SAVERM_RS26180	COG2902	Dehydrogenase
SAVERM_RS26195	COG1215	transferase activity, transferring glycosyl groups
SAVERM_RS26200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAVERM_RS26205	COG1134	teichoic acid transport
SAVERM_RS26230	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS26255	COG1846	Transcriptional regulator
SAVERM_RS26260	COG1764	response to oxidative stress
SAVERM_RS26270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAVERM_RS26275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAVERM_RS26280	COG0463	Glycosyl transferase, family 2
SAVERM_RS26280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SAVERM_RS26285	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS26290	COG1175	transmembrane transport
SAVERM_RS26295	COG1653	transport
SAVERM_RS26305	COG0515	serine threonine protein kinase
SAVERM_RS26310	COG0515	serine threonine protein kinase
SAVERM_RS26315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAVERM_RS26330	COG2884	Cell division ATP-binding protein ftsE
SAVERM_RS26335	COG2177	Part of the ABC transporter FtsEX involved in
SAVERM_RS26340	COG0793	Belongs to the peptidase S41A family
SAVERM_RS26345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAVERM_RS26370	COG2124	cytochrome p450
SAVERM_RS26380	COG0583	DNA-binding transcription factor activity
SAVERM_RS26410	COG2223	nitrite transmembrane transporter activity
SAVERM_RS26440	COG3973	AAA domain
SAVERM_RS26450	COG0776	regulation of translation
SAVERM_RS26455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAVERM_RS26460	COG1678	Uncharacterized ACR, COG1678
SAVERM_RS26475	COG1175	transmembrane transport
SAVERM_RS26480	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS26485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SAVERM_RS26500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAVERM_RS26535	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAVERM_RS26555	COG1174	glycine betaine transport
SAVERM_RS26560	COG0517	IMP dehydrogenase activity
SAVERM_RS26560	COG1125	glycine betaine transport
SAVERM_RS26565	COG1174	glycine betaine transport
SAVERM_RS26575	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SAVERM_RS26585	COG0277	FAD linked oxidase domain protein
SAVERM_RS26615	COG1335	isochorismatase
SAVERM_RS26625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SAVERM_RS26635	COG1113	amino acid transport
SAVERM_RS26665	COG1263	PTS System
SAVERM_RS26670	COG1263	PTS System
SAVERM_RS26675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAVERM_RS26680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SAVERM_RS26690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAVERM_RS26705	COG1309	transcriptional regulator
SAVERM_RS26730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAVERM_RS26745	COG4555	ABC transporter
SAVERM_RS26760	COG2733	membrane
SAVERM_RS26765	COG2271	Major facilitator Superfamily
SAVERM_RS26865	COG3764	Sortase (surface protein transpeptidase)
SAVERM_RS26885	COG4702	Belongs to the UPF0303 family
SAVERM_RS26890	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS26895	COG1940	carbohydrate kinase activity
SAVERM_RS26955	COG3397	chitin binding
SAVERM_RS26965	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS26980	COG1126	abc transporter atp-binding protein
SAVERM_RS26985	COG0765	amino acid transport
SAVERM_RS26990	COG0765	amino acid transport
SAVERM_RS27005	COG0154	amidase activity
SAVERM_RS27010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAVERM_RS27025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS27075	COG0406	alpha-ribazole phosphatase activity
SAVERM_RS27090	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAVERM_RS27100	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS27110	COG3979	chitinase
SAVERM_RS27120	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS27155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SAVERM_RS27160	COG4977	sequence-specific DNA binding
SAVERM_RS27170	COG0589	response to stress
SAVERM_RS27180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAVERM_RS27210	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SAVERM_RS27230	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS27245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SAVERM_RS27250	COG1309	transcriptional regulator
SAVERM_RS27260	COG1946	Acyl-CoA thioesterase
SAVERM_RS27275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS27285	COG0028	Belongs to the TPP enzyme family
SAVERM_RS27300	COG2356	endonuclease I
SAVERM_RS27305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAVERM_RS27305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SAVERM_RS27375	COG1472	Belongs to the glycosyl hydrolase 3 family
SAVERM_RS27420	COG1846	Transcriptional regulator
SAVERM_RS27420	COG0456	acetyltransferase
SAVERM_RS27425	COG1609	Transcriptional regulator
SAVERM_RS27430	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS27445	COG1869	D-ribose catabolic process
SAVERM_RS27450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS27460	COG1129	ABC transporter
SAVERM_RS27510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAVERM_RS27535	COG2409	Drug exporters of the RND superfamily
SAVERM_RS27555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS27565	COG3718	enzyme involved in inositol metabolism
SAVERM_RS27570	COG3962	Belongs to the TPP enzyme family
SAVERM_RS27640	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS27650	COG0728	peptidoglycan biosynthetic process
SAVERM_RS27660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SAVERM_RS27680	COG2304	oxidoreductase activity
SAVERM_RS27700	COG0629	single-stranded DNA binding
SAVERM_RS27725	COG2346	COG2346, Truncated hemoglobins
SAVERM_RS27730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SAVERM_RS27775	COG1486	melibiose metabolic process
SAVERM_RS27780	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS27785	COG1175	transmembrane transport
SAVERM_RS27800	COG0668	transmembrane transport
SAVERM_RS27815	COG0577	efflux transmembrane transporter activity
SAVERM_RS27815	COG1136	(ABC) transporter
SAVERM_RS27840	COG1846	Transcriptional regulator
SAVERM_RS27845	COG0697	spore germination
SAVERM_RS27935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SAVERM_RS27945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAVERM_RS27950	COG1113	amino acid transport
SAVERM_RS27960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS27965	COG1116	anion transmembrane transporter activity
SAVERM_RS27980	COG1940	carbohydrate kinase activity
SAVERM_RS27985	COG1268	BioY protein
SAVERM_RS28000	COG0515	serine threonine protein kinase
SAVERM_RS28005	COG1113	amino acid transport
SAVERM_RS28010	COG0698	ribose 5-phosphate isomerase
SAVERM_RS28020	COG4552	Acetyltransferase involved in intracellular survival and related
SAVERM_RS28030	COG1136	(ABC) transporter
SAVERM_RS28090	COG1674	ftsk spoiiie
SAVERM_RS28100	COG3594	Acyltransferase
SAVERM_RS28120	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAVERM_RS28125	COG0740	serine-type endopeptidase activity
SAVERM_RS28130	COG0740	serine-type endopeptidase activity
SAVERM_RS28135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAVERM_RS28145	COG0525	valine-tRNA ligase activity
SAVERM_RS28150	COG0285	dihydrofolate synthase activity
SAVERM_RS28160	COG0105	UTP biosynthetic process
SAVERM_RS28165	COG1077	Cell shape determining protein MreB Mrl
SAVERM_RS28185	COG0772	Belongs to the SEDS family
SAVERM_RS28215	COG1530	ribonuclease E activity
SAVERM_RS28225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAVERM_RS28230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAVERM_RS28235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAVERM_RS28245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SAVERM_RS28255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SAVERM_RS28270	COG0501	Belongs to the peptidase M48B family
SAVERM_RS28275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAVERM_RS28285	COG0799	negative regulation of ribosome biogenesis
SAVERM_RS28290	COG0588	phosphoglycerate mutase activity
SAVERM_RS28305	COG0477	Major facilitator Superfamily
SAVERM_RS28325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAVERM_RS28335	COG0495	leucyl-tRNA aminoacylation
SAVERM_RS28345	COG1307	EDD domain protein, DegV family
SAVERM_RS28350	COG1555	photosystem II stabilization
SAVERM_RS28355	COG1234	tRNA 3'-trailer cleavage
SAVERM_RS28680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SAVERM_RS28695	COG0268	Binds directly to 16S ribosomal RNA
SAVERM_RS28700	COG0481	GTPase activity
SAVERM_RS28740	COG1420	regulation of RNA biosynthetic process
SAVERM_RS28745	COG0484	heat shock protein binding
SAVERM_RS28765	COG0793	Belongs to the peptidase S41A family
SAVERM_RS28765	COG4946	Tricorn protease homolog
SAVERM_RS28770	COG0537	adenosine 5'-monophosphoramidase activity
SAVERM_RS28775	COG1234	tRNA 3'-trailer cleavage
SAVERM_RS28780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SAVERM_RS28795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS28800	COG4948	Mandelate Racemase Muconate Lactonizing
SAVERM_RS28805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS28815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAVERM_RS28825	COG2315	Protein conserved in bacteria
SAVERM_RS28870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAVERM_RS28905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAVERM_RS28915	COG2409	Drug exporters of the RND superfamily
SAVERM_RS28920	COG4585	Histidine kinase
SAVERM_RS28925	COG2197	response regulator
SAVERM_RS28935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS28940	COG4608	Belongs to the ABC transporter superfamily
SAVERM_RS28945	COG0444	Belongs to the ABC transporter superfamily
SAVERM_RS28955	COG0747	negative chemotaxis
SAVERM_RS28960	COG2186	Transcriptional regulator
SAVERM_RS28970	COG0534	Mate efflux family protein
SAVERM_RS28975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAVERM_RS28980	COG0019	diaminopimelate decarboxylase activity
SAVERM_RS28995	COG4166	transmembrane transport
SAVERM_RS29000	COG0601	transmembrane transport
SAVERM_RS29005	COG4171	peptide transport system, permease
SAVERM_RS29010	COG4172	Belongs to the ABC transporter superfamily
SAVERM_RS29015	COG4585	Histidine kinase
SAVERM_RS29020	COG2197	response regulator
SAVERM_RS29040	COG1381	Involved in DNA repair and RecF pathway recombination
SAVERM_RS29045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAVERM_RS29060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAVERM_RS29065	COG1121	(ABC) transporter
SAVERM_RS29070	COG3443	Belongs to the bacterial solute-binding protein 9 family
SAVERM_RS29070	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAVERM_RS29075	COG0423	glycine-tRNA ligase activity
SAVERM_RS29085	COG0667	Aldo Keto reductase
SAVERM_RS29130	COG0477	Major facilitator Superfamily
SAVERM_RS29160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SAVERM_RS29170	COG0574	Belongs to the PEP-utilizing enzyme family
SAVERM_RS29170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAVERM_RS29175	COG2205	protein histidine kinase activity
SAVERM_RS29180	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS29190	COG0659	secondary active sulfate transmembrane transporter activity
SAVERM_RS29195	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS29205	COG2146	nitrite reductase [NAD(P)H] activity
SAVERM_RS29205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAVERM_RS29230	COG2353	YceI-like domain
SAVERM_RS29260	COG2949	membrane
SAVERM_RS29270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SAVERM_RS29280	COG0358	DNA primase activity
SAVERM_RS29295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAVERM_RS29345	COG1132	(ABC) transporter
SAVERM_RS29415	COG1609	Transcriptional regulator
SAVERM_RS29470	COG3629	intracellular signal transduction
SAVERM_RS29470	COG3903	Transcriptional regulator
SAVERM_RS29510	COG1077	Cell shape determining protein MreB Mrl
SAVERM_RS29515	COG1404	Belongs to the peptidase S8 family
SAVERM_RS29520	COG0825	malonyl-CoA metabolic process
SAVERM_RS29520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAVERM_RS29525	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS29585	COG4981	capsule polysaccharide biosynthetic process
SAVERM_RS29590	COG0500	methyltransferase
SAVERM_RS29610	COG1414	Transcriptional regulator
SAVERM_RS29615	COG3386	PFAM SMP-30 Gluconolaconase
SAVERM_RS29640	COG2197	response regulator
SAVERM_RS29720	COG1136	(ABC) transporter
SAVERM_RS29720	COG0577	efflux transmembrane transporter activity
SAVERM_RS29725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAVERM_RS29730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS29740	COG4214	carbohydrate transport
SAVERM_RS29750	COG4213	ABC transporter substrate-binding protein
SAVERM_RS29765	COG4948	Mandelate Racemase Muconate Lactonizing
SAVERM_RS29785	COG2130	NADP-dependent
SAVERM_RS29830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAVERM_RS29835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS29840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS29855	COG1741	Belongs to the pirin family
SAVERM_RS29865	COG0789	Transcriptional regulator
SAVERM_RS29870	COG0667	Aldo Keto reductase
SAVERM_RS29885	COG1309	transcriptional regulator
SAVERM_RS29890	COG0477	Major facilitator Superfamily
SAVERM_RS29900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SAVERM_RS29905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAVERM_RS29950	COG1358	cellular component organization or biogenesis
SAVERM_RS30010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAVERM_RS30095	COG4122	O-methyltransferase activity
SAVERM_RS30115	COG2124	cytochrome p450
SAVERM_RS30120	COG0183	Belongs to the thiolase family
SAVERM_RS30125	COG3619	membrane
SAVERM_RS30145	COG3845	ABC transporter
SAVERM_RS30180	COG1309	transcriptional regulator
SAVERM_RS30185	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS30215	COG0860	N-Acetylmuramoyl-L-alanine amidase
SAVERM_RS30230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS30235	COG0477	Major facilitator Superfamily
SAVERM_RS30240	COG0183	Belongs to the thiolase family
SAVERM_RS30250	COG2197	response regulator
SAVERM_RS30255	COG4585	Histidine kinase
SAVERM_RS30260	COG2030	dehydratase
SAVERM_RS30270	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS30280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAVERM_RS30295	COG0800	Aldolase
SAVERM_RS30300	COG3022	response to hydroperoxide
SAVERM_RS30305	COG0557	exoribonuclease II activity
SAVERM_RS30400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SAVERM_RS30430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SAVERM_RS30470	COG2259	Doxx family
SAVERM_RS30480	COG1136	(ABC) transporter
SAVERM_RS30490	COG1686	Belongs to the peptidase S11 family
SAVERM_RS30500	COG3540	Alkaline phosphatase
SAVERM_RS30510	COG2814	Major facilitator Superfamily
SAVERM_RS30515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAVERM_RS30530	COG0584	glycerophosphoryl diester phosphodiesterase
SAVERM_RS30545	COG0672	)-iron permease
SAVERM_RS30550	COG2837	iron assimilation
SAVERM_RS30605	COG1994	Peptidase M50
SAVERM_RS30635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAVERM_RS30640	COG0477	Major facilitator Superfamily
SAVERM_RS30655	COG2814	Major facilitator Superfamily
SAVERM_RS30660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAVERM_RS30660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAVERM_RS30680	COG1959	2 iron, 2 sulfur cluster binding
SAVERM_RS30685	COG1017	nitric oxide dioxygenase activity
SAVERM_RS30685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SAVERM_RS30690	COG0174	glutamine synthetase
SAVERM_RS30695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SAVERM_RS30775	COG3511	phospholipase C
SAVERM_RS30780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SAVERM_RS30785	COG0697	spore germination
SAVERM_RS30790	COG0583	DNA-binding transcription factor activity
SAVERM_RS30800	COG1609	Transcriptional regulator
SAVERM_RS30810	COG1175	transmembrane transport
SAVERM_RS30815	COG3833	ABC-type maltose transport systems, permease component
SAVERM_RS30820	COG0366	Alpha amylase catalytic
SAVERM_RS30845	COG1309	transcriptional regulator
SAVERM_RS30875	COG2197	response regulator
SAVERM_RS30880	COG4585	Histidine kinase
SAVERM_RS30890	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS30940	COG0501	Belongs to the peptidase M48B family
SAVERM_RS30950	COG0174	glutamine synthetase
SAVERM_RS30970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAVERM_RS30975	COG0321	lipoyl(octanoyl) transferase activity
SAVERM_RS31000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAVERM_RS31025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SAVERM_RS31035	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAVERM_RS31040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAVERM_RS31045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAVERM_RS31050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SAVERM_RS31065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SAVERM_RS31065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAVERM_RS31070	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAVERM_RS31090	COG2226	methyltransferase
SAVERM_RS31115	COG2197	response regulator
SAVERM_RS31120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SAVERM_RS31125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAVERM_RS31145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS31155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAVERM_RS31160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAVERM_RS31170	COG1376	ErfK ybiS ycfS ynhG family protein
SAVERM_RS31180	COG1845	cytochrome c oxidase, subunit III
SAVERM_RS31185	COG2010	Cytochrome c
SAVERM_RS31190	COG0723	plastoquinol--plastocyanin reductase activity
SAVERM_RS31195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SAVERM_RS31200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAVERM_RS31205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAVERM_RS31245	COG0534	Mate efflux family protein
SAVERM_RS31280	COG0003	Pfam Anion-transporting ATPase
SAVERM_RS31290	COG1940	carbohydrate kinase activity
SAVERM_RS31325	COG4585	Histidine kinase
SAVERM_RS31335	COG0205	6-phosphofructokinase activity
SAVERM_RS31350	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SAVERM_RS31360	COG2193	ferroxidase activity
SAVERM_RS31365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAVERM_RS31375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SAVERM_RS31380	COG2815	serine threonine protein kinase
SAVERM_RS31380	COG0515	serine threonine protein kinase
SAVERM_RS31385	COG2022	thiamine diphosphate biosynthetic process
SAVERM_RS31395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS31395	COG2022	thiamine diphosphate biosynthetic process
SAVERM_RS31415	COG0352	thiamine-phosphate diphosphorylase activity
SAVERM_RS31440	COG1309	transcriptional regulator
SAVERM_RS31450	COG1126	abc transporter atp-binding protein
SAVERM_RS31460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAVERM_RS31480	COG0714	Associated with various cellular activities
SAVERM_RS31490	COG0275	rRNA processing
SAVERM_RS31505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAVERM_RS31515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAVERM_RS31520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAVERM_RS31530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAVERM_RS31535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAVERM_RS31540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAVERM_RS31545	COG1496	oxidoreductase activity
SAVERM_RS31555	COG1799	cell septum assembly
SAVERM_RS31565	COG3599	regulation of cell shape
SAVERM_RS31570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAVERM_RS31580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAVERM_RS31635	COG0587	DNA-directed DNA polymerase activity
SAVERM_RS31645	COG1432	Conserved Protein
SAVERM_RS31665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAVERM_RS31670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAVERM_RS31685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAVERM_RS31690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAVERM_RS31695	COG0131	Imidazoleglycerol-phosphate dehydratase
SAVERM_RS31700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAVERM_RS31705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAVERM_RS31710	COG0251	oxidation-reduction process
SAVERM_RS31715	COG0107	imidazoleglycerol-phosphate synthase activity
SAVERM_RS31730	COG2508	Transcriptional regulator
SAVERM_RS31735	COG0410	ABC transporter
SAVERM_RS31740	COG0411	ABC transporter
SAVERM_RS31745	COG0559	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS31765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SAVERM_RS31790	COG0134	indole-3-glycerol-phosphate synthase activity
SAVERM_RS31800	COG0133	tryptophan synthase activity
SAVERM_RS31805	COG0159	tryptophan synthase activity
SAVERM_RS31815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAVERM_RS31825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAVERM_RS31855	COG0070	glutamate synthase
SAVERM_RS31855	COG0069	glutamate synthase activity
SAVERM_RS31855	COG0067	glutamate synthase
SAVERM_RS31875	COG2304	oxidoreductase activity
SAVERM_RS31890	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS31895	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS31900	COG1309	transcriptional regulator
SAVERM_RS31905	COG0183	Belongs to the thiolase family
SAVERM_RS31925	COG1024	Enoyl-CoA hydratase
SAVERM_RS31935	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS31960	COG1605	Chorismate mutase
SAVERM_RS31960	COG0287	Prephenate dehydrogenase
SAVERM_RS31965	COG4566	intracellular signal transduction
SAVERM_RS31985	COG0737	Belongs to the 5'-nucleotidase family
SAVERM_RS32040	COG2050	protein possibly involved in aromatic compounds catabolism
SAVERM_RS32070	COG1643	Atp-dependent helicase
SAVERM_RS32075	COG2226	methyltransferase
SAVERM_RS32090	COG0237	dephospho-CoA kinase activity
SAVERM_RS32110	COG2226	methyltransferase
SAVERM_RS32190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAVERM_RS32195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SAVERM_RS32230	COG0598	Magnesium transport protein CorA
SAVERM_RS32235	COG2226	methyltransferase
SAVERM_RS32240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAVERM_RS32240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAVERM_RS32245	COG2313	pseudouridylate synthase activity
SAVERM_RS32265	COG0584	glycerophosphoryl diester phosphodiesterase
SAVERM_RS32275	COG0556	nucleotide-excision repair
SAVERM_RS32295	COG0387	Pfam Sodium calcium exchanger
SAVERM_RS32300	COG0477	Major facilitator Superfamily
SAVERM_RS32305	COG1619	proteins homologs of microcin C7 resistance protein MccF
SAVERM_RS32310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SAVERM_RS32320	COG0765	amino acid transport
SAVERM_RS32325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAVERM_RS32340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAVERM_RS32350	COG1609	Transcriptional regulator
SAVERM_RS32365	COG0322	excinuclease ABC activity
SAVERM_RS32370	COG1660	Displays ATPase and GTPase activities
SAVERM_RS32375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAVERM_RS32380	COG1481	regulation of sporulation
SAVERM_RS32390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SAVERM_RS32395	COG0126	phosphoglycerate kinase activity
SAVERM_RS32400	COG0149	triose-phosphate isomerase activity
SAVERM_RS32405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAVERM_RS32420	COG0166	Belongs to the GPI family
SAVERM_RS32430	COG1136	(ABC) transporter
SAVERM_RS32435	COG1695	Transcriptional regulator
SAVERM_RS32440	COG1653	transport
SAVERM_RS32445	COG0366	Alpha amylase catalytic
SAVERM_RS32450	COG1653	transport
SAVERM_RS32455	COG1175	transmembrane transport
SAVERM_RS32460	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS32465	COG0363	glucosamine-6-phosphate deaminase activity
SAVERM_RS32480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SAVERM_RS32490	COG0109	protoheme IX farnesyltransferase activity
SAVERM_RS32510	COG1612	heme a metabolic process
SAVERM_RS32540	COG0719	Fe-S assembly protein
SAVERM_RS32550	COG0396	ATPase activity
SAVERM_RS32555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAVERM_RS32560	COG0822	iron-sulfur transferase activity
SAVERM_RS32580	COG2076	Multidrug Resistance protein
SAVERM_RS32585	COG3226	Transcriptional regulator
SAVERM_RS32600	COG2171	N-acyltransferase activity
SAVERM_RS32615	COG1595	DNA-templated transcription, initiation
SAVERM_RS32625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS32680	COG1063	alcohol dehydrogenase
SAVERM_RS32685	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS32700	COG1349	DNA-binding transcription factor activity
SAVERM_RS32705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAVERM_RS32710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS32730	COG1234	tRNA 3'-trailer cleavage
SAVERM_RS32735	COG1802	Transcriptional regulator
SAVERM_RS32740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAVERM_RS32750	COG1175	transmembrane transport
SAVERM_RS32755	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS32775	COG1653	transport
SAVERM_RS32780	COG2755	lipolytic protein G-D-S-L family
SAVERM_RS32785	COG3866	Pectate lyase
SAVERM_RS32790	COG4677	pectinesterase activity
SAVERM_RS32815	COG3507	Belongs to the glycosyl hydrolase 43 family
SAVERM_RS32820	COG4733	cellulase activity
SAVERM_RS32835	COG1595	DNA-templated transcription, initiation
SAVERM_RS32840	COG2252	PERMEase
SAVERM_RS32845	COG0768	penicillin binding
SAVERM_RS32850	COG1414	Transcriptional regulator
SAVERM_RS32865	COG0477	Major facilitator Superfamily
SAVERM_RS32885	COG5285	phytanoyl-CoA dioxygenase
SAVERM_RS32890	COG1917	Cupin 2, conserved barrel domain protein
SAVERM_RS32895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS32900	COG0456	acetyltransferase
SAVERM_RS32905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SAVERM_RS32910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAVERM_RS32915	COG0765	amino acid transport
SAVERM_RS32935	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SAVERM_RS32970	COG1797	cobyrinic acid a,c-diamide synthase activity
SAVERM_RS32990	COG1492	cobalamin metabolic process
SAVERM_RS33015	COG0235	Class ii aldolase
SAVERM_RS33040	COG0488	(ABC) transporter
SAVERM_RS33090	COG3387	PFAM Glycoside hydrolase 15-related
SAVERM_RS33105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAVERM_RS33160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SAVERM_RS33180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS33185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SAVERM_RS33205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAVERM_RS33220	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS33225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAVERM_RS33235	COG2186	Transcriptional regulator
SAVERM_RS33255	COG3830	Belongs to the UPF0237 family
SAVERM_RS33255	COG0560	Phosphoserine phosphatase
SAVERM_RS33265	COG1716	ATPase activity
SAVERM_RS33265	COG0842	Transport permease protein
SAVERM_RS33265	COG1131	(ABC) transporter
SAVERM_RS33275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAVERM_RS33280	COG4221	oxidoreductase activity
SAVERM_RS33285	COG4585	Histidine kinase
SAVERM_RS33290	COG2197	response regulator
SAVERM_RS33305	COG1119	ATPase activity
SAVERM_RS33325	COG1881	PFAM PEBP family protein
SAVERM_RS33335	COG2094	Belongs to the DNA glycosylase MPG family
SAVERM_RS33375	COG0647	UMP catabolic process
SAVERM_RS33380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAVERM_RS33385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAVERM_RS33390	COG1120	ATPase activity
SAVERM_RS33410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAVERM_RS33420	COG0497	DNA recombination
SAVERM_RS33440	COG3387	PFAM Glycoside hydrolase 15-related
SAVERM_RS33445	COG0504	CTP synthase activity
SAVERM_RS33450	COG0494	nUDIX hydrolase
SAVERM_RS33460	COG0686	Belongs to the AlaDH PNT family
SAVERM_RS33475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAVERM_RS33480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAVERM_RS33485	COG1187	pseudouridine synthase activity
SAVERM_RS33500	COG3541	Predicted nucleotidyltransferase
SAVERM_RS33535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAVERM_RS33545	COG1160	GTP binding
SAVERM_RS33560	COG1652	LysM domain
SAVERM_RS33595	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS33605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAVERM_RS33615	COG0671	phosphoesterase, PA-phosphatase related
SAVERM_RS33625	COG0477	Major facilitator Superfamily
SAVERM_RS33630	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS33635	COG1799	cell septum assembly
SAVERM_RS33650	COG0765	amino acid transport
SAVERM_RS33660	COG1126	abc transporter atp-binding protein
SAVERM_RS33695	COG0587	DNA-directed DNA polymerase activity
SAVERM_RS33705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAVERM_RS33705	COG0662	Cupin 2, conserved barrel domain protein
SAVERM_RS33745	COG1725	Transcriptional regulator
SAVERM_RS33770	COG0726	polysaccharide deacetylase
SAVERM_RS33770	COG1649	PFAM Uncharacterised BCR, COG1649
SAVERM_RS33800	COG2755	lipolytic protein G-D-S-L family
SAVERM_RS33825	COG1595	DNA-templated transcription, initiation
SAVERM_RS33845	COG2188	Transcriptional regulator
SAVERM_RS33850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SAVERM_RS33860	COG1309	transcriptional regulator
SAVERM_RS33865	COG0243	molybdopterin cofactor binding
SAVERM_RS33870	COG2851	Citrate transporter
SAVERM_RS33905	COG0640	Transcriptional regulator
SAVERM_RS33915	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS33935	COG0789	Transcriptional regulator
SAVERM_RS33940	COG0072	phenylalanine-tRNA ligase activity
SAVERM_RS33940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAVERM_RS33965	COG3876	Protein conserved in bacteria
SAVERM_RS33975	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS34005	COG2149	membrane
SAVERM_RS34010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SAVERM_RS34020	COG3573	Dehydrogenase
SAVERM_RS34045	COG1063	alcohol dehydrogenase
SAVERM_RS34050	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS34060	COG3265	gluconokinase activity
SAVERM_RS34065	COG2186	Transcriptional regulator
SAVERM_RS34070	COG3012	SEC-C Motif Domain Protein
SAVERM_RS34075	COG0308	aminopeptidase N
SAVERM_RS34090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAVERM_RS34115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAVERM_RS34120	COG0667	Aldo Keto reductase
SAVERM_RS34125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS34135	COG0598	Magnesium transport protein CorA
SAVERM_RS34155	COG0215	cysteine-tRNA ligase activity
SAVERM_RS34165	COG1404	Belongs to the peptidase S8 family
SAVERM_RS34165	COG4935	Belongs to the peptidase S8 family
SAVERM_RS34175	COG2186	Transcriptional regulator
SAVERM_RS34180	COG0402	S-adenosylhomocysteine deaminase activity
SAVERM_RS34185	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SAVERM_RS34190	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAVERM_RS34200	COG3845	ABC transporter
SAVERM_RS34210	COG0235	Class ii aldolase
SAVERM_RS34210	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SAVERM_RS34215	COG0235	Class ii aldolase
SAVERM_RS34220	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SAVERM_RS34225	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SAVERM_RS34230	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SAVERM_RS34235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SAVERM_RS34240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAVERM_RS34245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAVERM_RS34250	COG1414	Transcriptional regulator
SAVERM_RS34255	COG0646	methionine synthase
SAVERM_RS34255	COG1410	methionine synthase
SAVERM_RS34265	COG0747	negative chemotaxis
SAVERM_RS34270	COG4166	transmembrane transport
SAVERM_RS34275	COG2197	response regulator
SAVERM_RS34290	COG0517	IMP dehydrogenase activity
SAVERM_RS34290	COG1994	Peptidase M50
SAVERM_RS34310	COG1222	aaa ATPase
SAVERM_RS34315	COG4122	O-methyltransferase activity
SAVERM_RS34325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAVERM_RS34330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAVERM_RS34335	COG1609	Transcriptional regulator
SAVERM_RS34345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SAVERM_RS34350	COG0545	Peptidyl-prolyl cis-trans isomerase
SAVERM_RS34380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAVERM_RS34385	COG0805	protein transport
SAVERM_RS34400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS34425	COG1309	transcriptional regulator
SAVERM_RS34455	COG0564	pseudouridine synthase activity
SAVERM_RS34490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAVERM_RS34495	COG4175	Glycine betaine
SAVERM_RS34495	COG0517	IMP dehydrogenase activity
SAVERM_RS34500	COG4176	ABC-type proline glycine betaine transport system permease component
SAVERM_RS34515	COG2226	methyltransferase
SAVERM_RS34520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAVERM_RS34535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAVERM_RS34545	COG0174	glutamine synthetase
SAVERM_RS34550	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS34555	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS34600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAVERM_RS34605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAVERM_RS34610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAVERM_RS34615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAVERM_RS34620	COG5002	protein histidine kinase activity
SAVERM_RS34625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAVERM_RS34630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAVERM_RS34630	COG0072	phenylalanine-tRNA ligase activity
SAVERM_RS34660	COG1649	PFAM Uncharacterised BCR, COG1649
SAVERM_RS34670	COG0697	spore germination
SAVERM_RS34705	COG0789	Transcriptional regulator
SAVERM_RS34725	COG0702	epimerase
SAVERM_RS34730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAVERM_RS34735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAVERM_RS34740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAVERM_RS34745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAVERM_RS34750	COG1438	arginine binding
SAVERM_RS34780	COG0745	RESPONSE REGULATOR receiver
SAVERM_RS34785	COG2205	protein histidine kinase activity
SAVERM_RS34805	COG0137	argininosuccinate synthase activity
SAVERM_RS34810	COG0165	Argininosuccinate lyase
SAVERM_RS34825	COG0477	Major facilitator Superfamily
SAVERM_RS34830	COG0318	PFAM AMP-dependent synthetase and ligase
SAVERM_RS34830	COG0204	Acyl-transferase
SAVERM_RS34860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAVERM_RS34865	COG2011	ABC-type metal ion transport system permease component
SAVERM_RS34870	COG1464	Belongs to the NlpA lipoprotein family
SAVERM_RS34875	COG1464	Belongs to the NlpA lipoprotein family
SAVERM_RS34890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SAVERM_RS34895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SAVERM_RS34895	COG1648	precorrin-2 dehydrogenase activity
SAVERM_RS34905	COG2816	NAD+ diphosphatase activity
SAVERM_RS34960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAVERM_RS35010	COG1175	transmembrane transport
SAVERM_RS35015	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS35045	COG5002	protein histidine kinase activity
SAVERM_RS35045	COG2176	DNA-directed DNA polymerase activity
SAVERM_RS35060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAVERM_RS35080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAVERM_RS35085	COG1560	Kdo2-lipid A biosynthetic process
SAVERM_RS35090	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS35095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SAVERM_RS35105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SAVERM_RS35110	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SAVERM_RS35115	COG0217	transcriptional regulatory protein
SAVERM_RS35120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SAVERM_RS35125	COG0632	four-way junction helicase activity
SAVERM_RS35130	COG2255	four-way junction helicase activity
SAVERM_RS35140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAVERM_RS35145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAVERM_RS35150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAVERM_RS35155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAVERM_RS35160	COG1196	nuclear chromosome segregation
SAVERM_RS35165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SAVERM_RS35175	COG0124	histidyl-tRNA synthetase
SAVERM_RS35190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAVERM_RS35205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAVERM_RS35210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAVERM_RS35215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAVERM_RS35220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAVERM_RS35225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAVERM_RS35230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAVERM_RS35235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAVERM_RS35245	COG0006	proline dipeptidase activity
SAVERM_RS35250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAVERM_RS35255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAVERM_RS35270	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAVERM_RS35275	COG0540	Belongs to the ATCase OTCase family
SAVERM_RS35280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAVERM_RS35290	COG0505	Belongs to the CarA family
SAVERM_RS35295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAVERM_RS35300	COG0167	dihydroorotate dehydrogenase activity
SAVERM_RS35305	COG0284	orotidine-5'-phosphate decarboxylase activity
SAVERM_RS35315	COG0194	GDP metabolic process
SAVERM_RS35320	COG1758	RNA polymerase activity
SAVERM_RS35330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAVERM_RS35345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAVERM_RS35355	COG2409	Drug exporters of the RND superfamily
SAVERM_RS35360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAVERM_RS35365	COG2390	Transcriptional regulator
SAVERM_RS35390	COG0531	amino acid
SAVERM_RS35415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SAVERM_RS35425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS35440	COG2233	PERMEase
SAVERM_RS35455	COG2223	nitrite transmembrane transporter activity
SAVERM_RS35460	COG1940	carbohydrate kinase activity
SAVERM_RS35460	COG1846	Transcriptional regulator
SAVERM_RS35470	COG3201	nicotinamide mononucleotide transporter
SAVERM_RS35475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAVERM_RS35475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAVERM_RS35480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAVERM_RS35485	COG0140	phosphoribosyl-ATP diphosphatase activity
SAVERM_RS35490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAVERM_RS35535	COG1309	transcriptional regulator
SAVERM_RS35545	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS35565	COG1216	Glycosyl transferase, family 2
SAVERM_RS35580	COG2270	Major facilitator Superfamily
SAVERM_RS35620	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS35625	COG0438	transferase activity, transferring glycosyl groups
SAVERM_RS35635	COG1984	allophanate hydrolase subunit 2
SAVERM_RS35640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SAVERM_RS35645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAVERM_RS35650	COG4336	lyase activity
SAVERM_RS35655	COG2814	Major facilitator Superfamily
SAVERM_RS35690	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS35700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAVERM_RS35720	COG1414	Transcriptional regulator
SAVERM_RS35725	COG2146	nitrite reductase [NAD(P)H] activity
SAVERM_RS35730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SAVERM_RS35745	COG2018	Roadblock/LC7 domain
SAVERM_RS35765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAVERM_RS35770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAVERM_RS35775	COG5002	protein histidine kinase activity
SAVERM_RS35775	COG5001	Diguanylate cyclase
SAVERM_RS35775	COG3447	MASE1 domain protein
SAVERM_RS35780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAVERM_RS35800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAVERM_RS35805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAVERM_RS35820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAVERM_RS35855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAVERM_RS35875	COG1716	ATPase activity
SAVERM_RS35895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAVERM_RS35905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAVERM_RS35905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAVERM_RS35935	COG0384	phenazine biosynthesis protein PhzF
SAVERM_RS35975	COG0697	spore germination
SAVERM_RS35980	COG0583	DNA-binding transcription factor activity
SAVERM_RS36025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAVERM_RS36040	COG2318	DinB family
SAVERM_RS36050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SAVERM_RS36060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS36075	COG1968	undecaprenyl-diphosphatase activity
SAVERM_RS36100	COG0183	Belongs to the thiolase family
SAVERM_RS36110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAVERM_RS36140	COG3942	CHAP domain
SAVERM_RS36145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS36165	COG0110	maltose O-acetyltransferase activity
SAVERM_RS36190	COG0640	Transcriptional regulator
SAVERM_RS36205	COG2318	DinB family
SAVERM_RS36215	COG1832	CoA-binding protein
SAVERM_RS36235	COG1739	Uncharacterized protein family UPF0029
SAVERM_RS36245	COG0420	3'-5' exonuclease activity
SAVERM_RS36250	COG0419	ATPase involved in DNA repair
SAVERM_RS36255	COG1522	sequence-specific DNA binding
SAVERM_RS36285	COG0626	cystathionine gamma-synthase activity
SAVERM_RS36300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAVERM_RS36315	COG1595	DNA-templated transcription, initiation
SAVERM_RS36320	COG2188	Transcriptional regulator
SAVERM_RS36325	COG1940	carbohydrate kinase activity
SAVERM_RS36330	COG2197	response regulator
SAVERM_RS36335	COG4585	Histidine kinase
SAVERM_RS36360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAVERM_RS36385	COG0456	acetyltransferase
SAVERM_RS36390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS36395	COG1136	(ABC) transporter
SAVERM_RS36395	COG0577	efflux transmembrane transporter activity
SAVERM_RS36400	COG0577	efflux transmembrane transporter activity
SAVERM_RS36400	COG1136	(ABC) transporter
SAVERM_RS36415	COG2226	methyltransferase
SAVERM_RS36420	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SAVERM_RS36430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SAVERM_RS36435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAVERM_RS36440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SAVERM_RS36480	COG0740	serine-type endopeptidase activity
SAVERM_RS36495	COG0831	urea catabolic process
SAVERM_RS36500	COG0832	Belongs to the urease beta subunit family
SAVERM_RS36505	COG0804	urea catabolic process
SAVERM_RS36515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAVERM_RS36520	COG0829	nickel cation binding
SAVERM_RS36535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAVERM_RS36540	COG1834	amidinotransferase
SAVERM_RS36550	COG3279	Response regulator of the LytR AlgR family
SAVERM_RS36560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAVERM_RS36565	COG3275	phosphorelay sensor kinase activity
SAVERM_RS36575	COG0515	serine threonine protein kinase
SAVERM_RS36575	COG2815	serine threonine protein kinase
SAVERM_RS36590	COG0205	6-phosphofructokinase activity
SAVERM_RS36595	COG3442	glutamine amidotransferase
SAVERM_RS36605	COG0242	peptide deformylase activity
SAVERM_RS36615	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS36625	COG2124	cytochrome p450
SAVERM_RS36630	COG3424	synthase
SAVERM_RS36645	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS36655	COG1793	dna ligase
SAVERM_RS36660	COG0492	ferredoxin-NADP+ reductase activity
SAVERM_RS36675	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS36680	COG1960	acyl-CoA dehydrogenase activity
SAVERM_RS36705	COG2188	Transcriptional regulator
SAVERM_RS36710	COG3962	Belongs to the TPP enzyme family
SAVERM_RS36715	COG3718	enzyme involved in inositol metabolism
SAVERM_RS36725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAVERM_RS36750	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS36755	COG1609	Transcriptional regulator
SAVERM_RS36780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SAVERM_RS36790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SAVERM_RS36815	COG1309	transcriptional regulator
SAVERM_RS36840	COG1366	Belongs to the anti-sigma-factor antagonist family
SAVERM_RS36840	COG2172	sigma factor antagonist activity
SAVERM_RS36840	COG2208	phosphoserine phosphatase activity
SAVERM_RS36865	COG1012	belongs to the aldehyde dehydrogenase family
SAVERM_RS36880	COG1940	carbohydrate kinase activity
SAVERM_RS36885	COG1070	Carbohydrate kinase
SAVERM_RS36890	COG2115	Belongs to the xylose isomerase family
SAVERM_RS36910	COG1819	glycosyl
SAVERM_RS36920	COG0477	Major facilitator Superfamily
SAVERM_RS36925	COG0673	inositol 2-dehydrogenase activity
SAVERM_RS36930	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS36940	COG1609	Transcriptional regulator
SAVERM_RS36950	COG0248	Ppx GppA phosphatase
SAVERM_RS36955	COG2890	protein-(glutamine-N5) methyltransferase activity
SAVERM_RS36970	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS36975	COG0596	Alpha beta hydrolase
SAVERM_RS36980	COG1733	regulation of RNA biosynthetic process
SAVERM_RS36985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAVERM_RS36990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SAVERM_RS37015	COG0351	phosphomethylpyrimidine kinase
SAVERM_RS37020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SAVERM_RS37035	COG1126	abc transporter atp-binding protein
SAVERM_RS37040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAVERM_RS37050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS37055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS37060	COG2838	Isocitrate dehydrogenase
SAVERM_RS37065	COG0668	transmembrane transport
SAVERM_RS37070	COG1024	Enoyl-CoA hydratase
SAVERM_RS37080	COG1132	(ABC) transporter
SAVERM_RS37085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAVERM_RS37135	COG1063	alcohol dehydrogenase
SAVERM_RS37145	COG0693	protein deglycase activity
SAVERM_RS37155	COG0656	L-ascorbic acid biosynthetic process
SAVERM_RS37165	COG0583	DNA-binding transcription factor activity
SAVERM_RS37175	COG0443	Heat shock 70 kDa protein
SAVERM_RS37180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAVERM_RS37195	COG0542	response to heat
SAVERM_RS37220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SAVERM_RS37235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAVERM_RS37255	COG0297	glycogen (starch) synthase activity
SAVERM_RS37260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAVERM_RS37265	COG3537	Alpha-1,2-mannosidase
SAVERM_RS37285	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS37305	COG1653	transport
SAVERM_RS37315	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS37325	COG1609	Transcriptional regulator
SAVERM_RS37330	COG5434	Belongs to the glycosyl hydrolase 28 family
SAVERM_RS37350	COG1175	transmembrane transport
SAVERM_RS37355	COG0395	ABC-type sugar transport system, permease component
SAVERM_RS37375	COG2186	Transcriptional regulator
SAVERM_RS37380	COG1879	ABC-type sugar transport system periplasmic component
SAVERM_RS37385	COG1129	ABC transporter
SAVERM_RS37395	COG4948	Mandelate Racemase Muconate Lactonizing
SAVERM_RS37430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAVERM_RS37455	COG0531	amino acid
SAVERM_RS37465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SAVERM_RS37465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAVERM_RS37505	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS37510	COG0583	DNA-binding transcription factor activity
SAVERM_RS37520	COG1053	succinate dehydrogenase
SAVERM_RS37525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SAVERM_RS37575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS37595	COG4264	IucA IucC family
SAVERM_RS37600	COG0019	diaminopimelate decarboxylase activity
SAVERM_RS37675	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SAVERM_RS37680	COG0121	glutamine amidotransferase
SAVERM_RS37685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SAVERM_RS37690	COG3572	ergothioneine biosynthetic process
SAVERM_RS37705	COG2268	Band 7 protein
SAVERM_RS37720	COG1609	Transcriptional regulator
SAVERM_RS37725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAVERM_RS37735	COG0242	peptide deformylase activity
SAVERM_RS37780	COG1132	(ABC) transporter
SAVERM_RS37785	COG1819	glycosyl
SAVERM_RS37795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAVERM_RS37820	COG1024	Enoyl-CoA hydratase
SAVERM_RS37820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAVERM_RS37830	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SAVERM_RS37860	COG0375	protein maturation
SAVERM_RS37865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SAVERM_RS37870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SAVERM_RS37875	COG0298	carbon dioxide binding
SAVERM_RS37880	COG0409	Hydrogenase expression formation protein
SAVERM_RS37885	COG0309	Hydrogenase expression formation protein (HypE)
SAVERM_RS37905	COG2080	2 iron, 2 sulfur cluster binding
SAVERM_RS37910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SAVERM_RS37915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SAVERM_RS37950	COG2197	response regulator
SAVERM_RS37960	COG0366	Alpha amylase catalytic
SAVERM_RS37970	COG3281	Trehalose synthase
SAVERM_RS37975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAVERM_RS37980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAVERM_RS38000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS38010	COG0577	efflux transmembrane transporter activity
SAVERM_RS38010	COG1136	(ABC) transporter
SAVERM_RS38015	COG1174	glycine betaine transport
SAVERM_RS38030	COG1125	glycine betaine transport
SAVERM_RS38030	COG0517	IMP dehydrogenase activity
SAVERM_RS38035	COG1556	Lactate utilization protein
SAVERM_RS38040	COG1139	Iron-sulfur cluster binding protein
SAVERM_RS38045	COG0247	lactate metabolic process
SAVERM_RS38050	COG1070	Carbohydrate kinase
SAVERM_RS38055	COG3347	Dehydrogenase
SAVERM_RS38055	COG1028	Short-chain dehydrogenase reductase Sdr
SAVERM_RS38065	COG1129	ABC transporter
SAVERM_RS38095	COG1609	Transcriptional regulator
SAVERM_RS38105	COG1595	DNA-templated transcription, initiation
SAVERM_RS38110	COG1357	PFAM Pentapeptide repeats (8 copies)
SAVERM_RS38120	COG1309	transcriptional regulator
SAVERM_RS38130	COG2706	6-phosphogluconolactonase activity
SAVERM_RS38185	COG1796	DNA polymerase
SAVERM_RS38185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SAVERM_RS38230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAVERM_RS38245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAVERM_RS38310	COG0435	Glutathione S-transferase
SAVERM_RS38345	COG2124	cytochrome p450
SAVERM_RS38380	COG0596	Alpha beta hydrolase
SAVERM_RS38405	COG3250	beta-galactosidase activity
SAVERM_RS38415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SAVERM_RS38430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SAVERM_RS38455	COG0671	phosphoesterase, PA-phosphatase related
SAVERM_RS38465	COG3832	glyoxalase III activity
SAVERM_RS38475	COG2274	protein secretion by the type I secretion system
SAVERM_RS38505	COG1132	(ABC) transporter
SAVERM_RS38510	COG1132	(ABC) transporter
SAVERM_RS38520	COG0515	serine threonine protein kinase
SAVERM_RS38535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SAVERM_RS38605	COG1674	ftsk spoiiie
SAVERM_RS38685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAVERM_RS38690	COG1518	maintenance of DNA repeat elements
SAVERM_RS38705	COG1857	crispr-associated protein
SAVERM_RS38810	COG3335	DDE superfamily endonuclease