locus-tag	class	description
G4Z16_RS00020	COG1609	Transcriptional regulator
G4Z16_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS00075	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Z16_RS00095	COG1320	monovalent cation:proton antiporter activity
G4Z16_RS00110	COG0651	ATP synthesis coupled electron transport
G4Z16_RS00115	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Z16_RS00120	COG2111	Na H antiporter
G4Z16_RS00120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Z16_RS00135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Z16_RS00150	COG2270	Major facilitator Superfamily
G4Z16_RS00165	COG1216	Glycosyl transferase, family 2
G4Z16_RS00195	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS00205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Z16_RS00205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Z16_RS00215	COG1228	amidohydrolase
G4Z16_RS00220	COG0583	DNA-binding transcription factor activity
G4Z16_RS00225	COG0667	Aldo Keto reductase
G4Z16_RS00230	COG0667	Aldo Keto reductase
G4Z16_RS00235	COG0656	L-ascorbic acid biosynthetic process
G4Z16_RS00240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS00245	COG3739	integral membrane protein
G4Z16_RS00265	COG2208	phosphoserine phosphatase activity
G4Z16_RS00275	COG1132	(ABC) transporter
G4Z16_RS00280	COG0277	FAD linked oxidase domain protein
G4Z16_RS00295	COG1132	(ABC) transporter
G4Z16_RS00300	COG1132	(ABC) transporter
G4Z16_RS00315	COG1946	Acyl-CoA thioesterase
G4Z16_RS00325	COG2018	Roadblock/LC7 domain
G4Z16_RS00360	COG2755	lipolytic protein G-D-S-L family
G4Z16_RS00390	COG1113	amino acid transport
G4Z16_RS00405	COG2115	Belongs to the xylose isomerase family
G4Z16_RS00410	COG1070	Carbohydrate kinase
G4Z16_RS00430	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS00440	COG3458	cephalosporin-C deacetylase activity
G4Z16_RS00475	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS00525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Z16_RS00655	COG0300	oxidoreductase activity
G4Z16_RS00670	COG1280	lysine exporter protein (LysE YggA)
G4Z16_RS00705	COG0587	DNA-directed DNA polymerase activity
G4Z16_RS00875	COG0546	phosphoglycolate phosphatase activity
G4Z16_RS00995	COG0159	tryptophan synthase activity
G4Z16_RS01010	COG0305	Participates in initiation and elongation during chromosome replication
G4Z16_RS01080	COG0583	DNA-binding transcription factor activity
G4Z16_RS01085	COG1846	Transcriptional regulator
G4Z16_RS01085	COG1940	carbohydrate kinase activity
G4Z16_RS01130	COG1024	Enoyl-CoA hydratase
G4Z16_RS01135	COG2186	Transcriptional regulator
G4Z16_RS01155	COG1414	Transcriptional regulator
G4Z16_RS01160	COG0246	Mannitol dehydrogenase
G4Z16_RS01170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z16_RS01180	COG0477	Major facilitator Superfamily
G4Z16_RS01185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4Z16_RS01210	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Z16_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS01260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Z16_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS01290	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS01305	COG4638	Rieske (2fe-2S)
G4Z16_RS01390	COG3629	intracellular signal transduction
G4Z16_RS01390	COG3903	Transcriptional regulator
G4Z16_RS01395	COG3903	Transcriptional regulator
G4Z16_RS01395	COG3629	intracellular signal transduction
G4Z16_RS01450	COG1252	NADH dehydrogenase
G4Z16_RS01475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G4Z16_RS01495	COG2409	Drug exporters of the RND superfamily
G4Z16_RS01500	COG4977	sequence-specific DNA binding
G4Z16_RS01515	COG0477	Major facilitator Superfamily
G4Z16_RS01575	COG0028	Belongs to the TPP enzyme family
G4Z16_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS01605	COG2945	thiolester hydrolase activity
G4Z16_RS01605	COG0596	Alpha beta hydrolase
G4Z16_RS01610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Z16_RS01645	COG0028	Belongs to the TPP enzyme family
G4Z16_RS01675	COG0583	DNA-binding transcription factor activity
G4Z16_RS01705	COG1175	transmembrane transport
G4Z16_RS01715	COG1609	Transcriptional regulator
G4Z16_RS01735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Z16_RS01735	COG3153	acetyltransferase
G4Z16_RS01745	COG0154	amidase activity
G4Z16_RS01760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4Z16_RS01770	COG0667	Aldo Keto reductase
G4Z16_RS01775	COG3395	kinase activity
G4Z16_RS01780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4Z16_RS01785	COG1349	DNA-binding transcription factor activity
G4Z16_RS01835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Z16_RS01850	COG1937	Protein conserved in bacteria
G4Z16_RS01860	COG0640	Transcriptional regulator
G4Z16_RS01895	COG2814	Major facilitator Superfamily
G4Z16_RS01900	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4Z16_RS01920	COG0598	Magnesium transport protein CorA
G4Z16_RS01935	COG0531	amino acid
G4Z16_RS01940	COG0598	Magnesium transport protein CorA
G4Z16_RS01955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G4Z16_RS01960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G4Z16_RS01965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G4Z16_RS02005	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4Z16_RS02010	COG1595	DNA-templated transcription, initiation
G4Z16_RS02030	COG3424	synthase
G4Z16_RS02055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Z16_RS02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS02065	COG0243	molybdopterin cofactor binding
G4Z16_RS02080	COG4977	sequence-specific DNA binding
G4Z16_RS02105	COG4585	Histidine kinase
G4Z16_RS02110	COG2197	response regulator
G4Z16_RS02120	COG0477	Major facilitator Superfamily
G4Z16_RS02125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z16_RS02165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4Z16_RS02190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4Z16_RS02230	COG1725	Transcriptional regulator
G4Z16_RS02235	COG1131	(ABC) transporter
G4Z16_RS02280	COG3973	AAA domain
G4Z16_RS02285	COG4941	Belongs to the sigma-70 factor family
G4Z16_RS02290	COG3795	YCII-related domain
G4Z16_RS02325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4Z16_RS02335	COG2197	response regulator
G4Z16_RS02340	COG0142	geranyltranstransferase activity
G4Z16_RS02350	COG2124	cytochrome p450
G4Z16_RS02360	COG2814	Major facilitator Superfamily
G4Z16_RS02385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4Z16_RS02400	COG0492	ferredoxin-NADP+ reductase activity
G4Z16_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS02425	COG2030	dehydratase
G4Z16_RS02430	COG0492	ferredoxin-NADP+ reductase activity
G4Z16_RS02435	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z16_RS02460	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS02465	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Z16_RS02470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS02485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Z16_RS02490	COG1053	succinate dehydrogenase
G4Z16_RS02500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS02505	COG2301	Belongs to the HpcH HpaI aldolase family
G4Z16_RS02515	COG2079	MmgE PrpD family protein
G4Z16_RS02520	COG2271	Major facilitator Superfamily
G4Z16_RS02575	COG1741	Belongs to the pirin family
G4Z16_RS02590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Z16_RS02595	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS02645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4Z16_RS02665	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS02690	COG1063	alcohol dehydrogenase
G4Z16_RS02695	COG0246	Mannitol dehydrogenase
G4Z16_RS02700	COG2271	Major facilitator Superfamily
G4Z16_RS02705	COG1414	Transcriptional regulator
G4Z16_RS02710	COG0154	amidase activity
G4Z16_RS02715	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS02720	COG2197	response regulator
G4Z16_RS02745	COG0477	Major facilitator Superfamily
G4Z16_RS02750	COG1309	transcriptional regulator
G4Z16_RS02755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4Z16_RS02760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4Z16_RS02785	COG1175	transmembrane transport
G4Z16_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS02820	COG0431	NADPH-dependent FMN reductase
G4Z16_RS02830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z16_RS02860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4Z16_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS02885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS02890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Z16_RS02895	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS02925	COG1278	Cold shock
G4Z16_RS02985	COG0640	Transcriptional regulator
G4Z16_RS02995	COG0798	PFAM Bile acid sodium symporter
G4Z16_RS03005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Z16_RS03015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Z16_RS03030	COG0657	acetylesterase activity
G4Z16_RS03040	COG2207	Transcriptional regulator
G4Z16_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS03085	COG2723	6-phospho-beta-galactosidase activity
G4Z16_RS03100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G4Z16_RS03110	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS03115	COG1175	transmembrane transport
G4Z16_RS03135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Z16_RS03155	COG0277	FAD linked oxidase domain protein
G4Z16_RS03175	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS03180	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS03185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4Z16_RS03190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4Z16_RS03195	COG0583	DNA-binding transcription factor activity
G4Z16_RS03200	COG0183	Belongs to the thiolase family
G4Z16_RS03205	COG0477	Major facilitator Superfamily
G4Z16_RS03225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS03235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Z16_RS03240	COG2259	Doxx family
G4Z16_RS03245	COG1793	dna ligase
G4Z16_RS03260	COG0515	serine threonine protein kinase
G4Z16_RS03260	COG2815	serine threonine protein kinase
G4Z16_RS03280	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G4Z16_RS03285	COG0121	glutamine amidotransferase
G4Z16_RS03290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Z16_RS03305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Z16_RS03310	COG0589	response to stress
G4Z16_RS03355	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS03370	COG1316	TRANSCRIPTIONal
G4Z16_RS03375	COG0723	plastoquinol--plastocyanin reductase activity
G4Z16_RS03375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z16_RS03435	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS03455	COG2018	Roadblock/LC7 domain
G4Z16_RS03465	COG2365	Tyrosine phosphatase family
G4Z16_RS03485	COG1657	PFAM Prenyltransferase squalene oxidase
G4Z16_RS03495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4Z16_RS03515	COG2409	Drug exporters of the RND superfamily
G4Z16_RS03520	COG1388	LysM domain
G4Z16_RS03520	COG1134	teichoic acid transport
G4Z16_RS03525	COG0842	Transport permease protein
G4Z16_RS03565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4Z16_RS03575	COG1024	Enoyl-CoA hydratase
G4Z16_RS03585	COG2183	response to ionizing radiation
G4Z16_RS03595	COG0488	(ABC) transporter
G4Z16_RS03650	COG2124	cytochrome p450
G4Z16_RS03660	COG0789	Transcriptional regulator
G4Z16_RS03670	COG0183	Belongs to the thiolase family
G4Z16_RS03675	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS03680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS03685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS03690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Z16_RS03700	COG1349	DNA-binding transcription factor activity
G4Z16_RS03705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS03720	COG3757	hydrolase, family 25
G4Z16_RS03720	COG3409	Peptidoglycan-binding domain 1 protein
G4Z16_RS03730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Z16_RS03745	COG0542	response to heat
G4Z16_RS03760	COG0596	Alpha beta hydrolase
G4Z16_RS03765	COG2208	phosphoserine phosphatase activity
G4Z16_RS03765	COG2770	Histidine kinase
G4Z16_RS03780	COG2186	Transcriptional regulator
G4Z16_RS03805	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS03810	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS03820	COG2226	methyltransferase
G4Z16_RS03890	COG0702	epimerase
G4Z16_RS03900	COG0730	response to heat
G4Z16_RS03915	COG0596	Alpha beta hydrolase
G4Z16_RS03925	COG1070	Carbohydrate kinase
G4Z16_RS03940	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS03945	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS03950	COG1129	ABC transporter
G4Z16_RS03955	COG1879	ABC-type sugar transport system periplasmic component
G4Z16_RS03975	COG0531	amino acid
G4Z16_RS03980	COG3647	Membrane
G4Z16_RS03985	COG0583	DNA-binding transcription factor activity
G4Z16_RS04030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Z16_RS04040	COG1113	amino acid transport
G4Z16_RS04045	COG2186	Transcriptional regulator
G4Z16_RS04085	COG2186	Transcriptional regulator
G4Z16_RS04115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Z16_RS04115	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Z16_RS04115	COG1042	CoA-binding domain protein
G4Z16_RS04120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4Z16_RS04125	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS04130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G4Z16_RS04135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4Z16_RS04150	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Z16_RS04160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS04170	COG2223	nitrite transmembrane transporter activity
G4Z16_RS04205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Z16_RS04235	COG3209	COG3209 Rhs family protein
G4Z16_RS04260	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS04265	COG1879	ABC-type sugar transport system periplasmic component
G4Z16_RS04270	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS04275	COG1129	ABC transporter
G4Z16_RS04280	COG1940	carbohydrate kinase activity
G4Z16_RS04310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4Z16_RS04315	COG3383	formate dehydrogenase (NAD+) activity
G4Z16_RS04320	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4Z16_RS04330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G4Z16_RS04365	COG3383	formate dehydrogenase (NAD+) activity
G4Z16_RS04400	COG0656	L-ascorbic acid biosynthetic process
G4Z16_RS04405	COG1595	DNA-templated transcription, initiation
G4Z16_RS04420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Z16_RS04425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Z16_RS04450	COG2154	pterin-4-alpha-carbinolamine dehydratase
G4Z16_RS04460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4Z16_RS04460	COG1796	DNA polymerase
G4Z16_RS04510	COG0028	Belongs to the TPP enzyme family
G4Z16_RS04540	COG4106	trans-aconitate 2-methyltransferase activity
G4Z16_RS04550	COG1063	alcohol dehydrogenase
G4Z16_RS04575	COG0457	Tetratricopeptide repeat
G4Z16_RS04585	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
G4Z16_RS04590	COG1309	transcriptional regulator
G4Z16_RS04595	COG0596	Alpha beta hydrolase
G4Z16_RS04605	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4Z16_RS04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z16_RS04620	COG2362	D-Aminopeptidase
G4Z16_RS04650	COG1653	transport
G4Z16_RS04655	COG1175	transmembrane transport
G4Z16_RS04660	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS04670	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS04680	COG0667	Aldo Keto reductase
G4Z16_RS04695	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS04700	COG1309	transcriptional regulator
G4Z16_RS04720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS04720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS04735	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS04740	COG0688	phosphatidylethanolamine metabolic process
G4Z16_RS04765	COG1929	Belongs to the glycerate kinase type-1 family
G4Z16_RS04775	COG0483	inositol monophosphate 1-phosphatase activity
G4Z16_RS04790	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS04795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Z16_RS04860	COG3903	Transcriptional regulator
G4Z16_RS04860	COG3629	intracellular signal transduction
G4Z16_RS04875	COG2175	clavaminate synthase activity
G4Z16_RS04880	COG0028	Belongs to the TPP enzyme family
G4Z16_RS04885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4Z16_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS04910	COG0483	inositol monophosphate 1-phosphatase activity
G4Z16_RS04915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4Z16_RS04925	COG2378	regulation of single-species biofilm formation
G4Z16_RS04935	COG1953	Uracil, thiamine, allantoin
G4Z16_RS04945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Z16_RS04950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Z16_RS04965	COG0405	Gamma-glutamyltransferase
G4Z16_RS04990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4Z16_RS04995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Z16_RS05005	COG1940	carbohydrate kinase activity
G4Z16_RS05030	COG2188	Transcriptional regulator
G4Z16_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Z16_RS05055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Z16_RS05060	COG1053	succinate dehydrogenase
G4Z16_RS05065	COG1335	isochorismatase
G4Z16_RS05095	COG0800	Aldolase
G4Z16_RS05100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z16_RS05105	COG1940	carbohydrate kinase activity
G4Z16_RS05115	COG1175	transmembrane transport
G4Z16_RS05120	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS05125	COG2723	6-phospho-beta-galactosidase activity
G4Z16_RS05140	COG4266	Belongs to the allantoicase family
G4Z16_RS05145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Z16_RS05150	COG1414	Transcriptional regulator
G4Z16_RS05175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G4Z16_RS05190	COG0789	Transcriptional regulator
G4Z16_RS05230	COG2233	PERMEase
G4Z16_RS05245	COG2351	hydroxyisourate hydrolase activity
G4Z16_RS05275	COG3622	Belongs to the hyi family
G4Z16_RS05280	COG2084	Dehydrogenase
G4Z16_RS05285	COG3960	tartronate-semialdehyde synthase activity
G4Z16_RS05295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4Z16_RS05330	COG3608	succinylglutamate desuccinylase aspartoacylase
G4Z16_RS05330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4Z16_RS05335	COG2252	PERMEase
G4Z16_RS05340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS05355	COG3835	regulator
G4Z16_RS05390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Z16_RS05395	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS05425	COG2207	Transcriptional regulator
G4Z16_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS05435	COG1063	alcohol dehydrogenase
G4Z16_RS05440	COG2814	Major facilitator Superfamily
G4Z16_RS05455	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS05460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS05500	COG3321	synthase
G4Z16_RS05500	COG0604	alcohol dehydrogenase
G4Z16_RS05515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS05535	COG2271	Major facilitator Superfamily
G4Z16_RS05540	COG1609	Transcriptional regulator
G4Z16_RS05555	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS05560	COG2205	protein histidine kinase activity
G4Z16_RS05570	COG1522	sequence-specific DNA binding
G4Z16_RS05575	COG0626	cystathionine gamma-synthase activity
G4Z16_RS05585	COG0513	Belongs to the DEAD box helicase family
G4Z16_RS05590	COG1278	Cold shock
G4Z16_RS05600	COG1802	Transcriptional regulator
G4Z16_RS05640	COG1162	GTPase activity
G4Z16_RS05650	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS05660	COG2252	PERMEase
G4Z16_RS05680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Z16_RS05690	COG0175	sulfate reduction
G4Z16_RS05695	COG0529	Catalyzes the synthesis of activated sulfate
G4Z16_RS05715	COG1116	anion transmembrane transporter activity
G4Z16_RS05720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Z16_RS05730	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS05765	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G4Z16_RS05780	COG0477	Major facilitator Superfamily
G4Z16_RS05790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4Z16_RS05795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4Z16_RS05820	COG0789	Transcriptional regulator
G4Z16_RS05835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS05840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Z16_RS05845	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS05880	COG3253	May function as heme-dependent peroxidase
G4Z16_RS05885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4Z16_RS05890	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4Z16_RS05895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4Z16_RS05905	COG2197	response regulator
G4Z16_RS05920	COG0183	Belongs to the thiolase family
G4Z16_RS05925	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS05925	COG1024	Enoyl-CoA hydratase
G4Z16_RS05940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4Z16_RS05945	COG4214	carbohydrate transport
G4Z16_RS05955	COG4213	ABC transporter substrate-binding protein
G4Z16_RS05960	COG1940	carbohydrate kinase activity
G4Z16_RS05965	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS05970	COG1175	transmembrane transport
G4Z16_RS05975	COG1653	transport
G4Z16_RS05980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4Z16_RS05985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4Z16_RS05990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4Z16_RS06000	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Z16_RS06045	COG1309	transcriptional regulator
G4Z16_RS06085	COG0477	Major facilitator Superfamily
G4Z16_RS06175	COG3119	arylsulfatase activity
G4Z16_RS06255	COG2124	cytochrome p450
G4Z16_RS06265	COG1414	Transcriptional regulator
G4Z16_RS06270	COG1177	transmembrane transport
G4Z16_RS06275	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4Z16_RS06280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4Z16_RS06285	COG3842	ATPase activity
G4Z16_RS06300	COG0640	Transcriptional regulator
G4Z16_RS06330	COG0431	NADPH-dependent FMN reductase
G4Z16_RS06365	COG1902	pentaerythritol trinitrate reductase activity
G4Z16_RS06370	COG1024	Enoyl-CoA hydratase
G4Z16_RS06395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Z16_RS06410	COG2040	homocysteine
G4Z16_RS06415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS06445	COG1819	glycosyl
G4Z16_RS06455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Z16_RS06465	COG0604	alcohol dehydrogenase
G4Z16_RS06465	COG3321	synthase
G4Z16_RS06520	COG1131	(ABC) transporter
G4Z16_RS06560	COG1131	(ABC) transporter
G4Z16_RS06590	COG0596	Alpha beta hydrolase
G4Z16_RS06595	COG1335	isochorismatase
G4Z16_RS06620	COG0477	Major facilitator Superfamily
G4Z16_RS06625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Z16_RS06630	COG2309	aminopeptidase activity
G4Z16_RS06640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4Z16_RS06660	COG0009	L-threonylcarbamoyladenylate synthase
G4Z16_RS06665	COG3152	Membrane
G4Z16_RS06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Z16_RS06735	COG0531	amino acid
G4Z16_RS06740	COG0569	domain protein
G4Z16_RS06765	COG0756	dUTP diphosphatase activity
G4Z16_RS06790	COG2205	protein histidine kinase activity
G4Z16_RS06795	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS06810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4Z16_RS06835	COG1435	thymidine kinase activity
G4Z16_RS06855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z16_RS06860	COG0739	heme binding
G4Z16_RS06870	COG0612	Peptidase, M16
G4Z16_RS06875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Z16_RS06880	COG0523	cobalamin synthesis protein
G4Z16_RS06885	COG3290	protein histidine kinase activity
G4Z16_RS06895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS06905	COG0187	DNA topoisomerase II activity
G4Z16_RS06920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Z16_RS06950	COG0514	ATP-dependent DNA helicase (RecQ)
G4Z16_RS06960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4Z16_RS06980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Z16_RS06985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G4Z16_RS06990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Z16_RS07025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4Z16_RS07035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Z16_RS07040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G4Z16_RS07070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4Z16_RS07095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Z16_RS07140	COG0515	serine threonine protein kinase
G4Z16_RS07140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Z16_RS07170	COG2205	protein histidine kinase activity
G4Z16_RS07180	COG1126	abc transporter atp-binding protein
G4Z16_RS07185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z16_RS07190	COG0765	amino acid transport
G4Z16_RS07195	COG0765	amino acid transport
G4Z16_RS07210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4Z16_RS07235	COG1201	RNA secondary structure unwinding
G4Z16_RS07240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Z16_RS07245	COG1396	sequence-specific DNA binding
G4Z16_RS07250	COG1546	Belongs to the CinA family
G4Z16_RS07250	COG1058	Belongs to the CinA family
G4Z16_RS07260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Z16_RS07270	COG1674	ftsk spoiiie
G4Z16_RS07280	COG3437	response regulator, receiver
G4Z16_RS07280	COG2205	protein histidine kinase activity
G4Z16_RS07280	COG3850	Histidine kinase
G4Z16_RS07280	COG4999	Histidine kinase
G4Z16_RS07285	COG2770	Histidine kinase
G4Z16_RS07285	COG2208	phosphoserine phosphatase activity
G4Z16_RS07315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4Z16_RS07320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS07325	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G4Z16_RS07345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4Z16_RS07350	COG0612	Peptidase, M16
G4Z16_RS07355	COG1185	polyribonucleotide nucleotidyltransferase activity
G4Z16_RS07360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G4Z16_RS07370	COG1674	ftsk spoiiie
G4Z16_RS07425	COG1404	Belongs to the peptidase S8 family
G4Z16_RS07455	COG0455	bacterial-type flagellum organization
G4Z16_RS07470	COG1349	DNA-binding transcription factor activity
G4Z16_RS07480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4Z16_RS07485	COG3395	kinase activity
G4Z16_RS07490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4Z16_RS07495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4Z16_RS07505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4Z16_RS07520	COG0779	Required for maturation of 30S ribosomal subunits
G4Z16_RS07545	COG1024	Enoyl-CoA hydratase
G4Z16_RS07550	COG0640	Transcriptional regulator
G4Z16_RS07560	COG2851	Citrate transporter
G4Z16_RS07565	COG0583	DNA-binding transcription factor activity
G4Z16_RS07570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS07580	COG0442	prolyl-tRNA aminoacylation
G4Z16_RS07595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G4Z16_RS07600	COG0750	zinc metalloprotease
G4Z16_RS07605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4Z16_RS07615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4Z16_RS07630	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS07635	COG2508	Transcriptional regulator
G4Z16_RS07660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z16_RS07670	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4Z16_RS07675	COG3842	ATPase activity
G4Z16_RS07695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G4Z16_RS07710	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS07720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4Z16_RS07735	COG0028	Belongs to the TPP enzyme family
G4Z16_RS07740	COG1136	(ABC) transporter
G4Z16_RS07755	COG3842	ATPase activity
G4Z16_RS07770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4Z16_RS07810	COG0233	cytoplasmic translational termination
G4Z16_RS07815	COG0528	UMP kinase activity
G4Z16_RS07820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4Z16_RS07825	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Z16_RS07830	COG4942	peptidase
G4Z16_RS07840	COG1191	sigma factor activity
G4Z16_RS07855	COG0792	nuclease activity
G4Z16_RS07865	COG0681	Belongs to the peptidase S26 family
G4Z16_RS07870	COG0681	Belongs to the peptidase S26 family
G4Z16_RS07875	COG0681	Belongs to the peptidase S26 family
G4Z16_RS07880	COG0681	Belongs to the peptidase S26 family
G4Z16_RS07885	COG0335	large ribosomal subunit rRNA binding
G4Z16_RS07890	COG0336	Belongs to the RNA methyltransferase TrmD family
G4Z16_RS07895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4Z16_RS07900	COG1837	Belongs to the UPF0109 family
G4Z16_RS07905	COG0228	four-way junction DNA binding
G4Z16_RS07935	COG1735	metal-dependent hydrolase with the TIM-barrel fold
G4Z16_RS07940	COG0626	cystathionine gamma-synthase activity
G4Z16_RS07945	COG3457	Alanine racemase
G4Z16_RS07950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G4Z16_RS07970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G4Z16_RS08000	COG0477	Major facilitator Superfamily
G4Z16_RS08005	COG1196	nuclear chromosome segregation
G4Z16_RS08015	COG1254	Belongs to the acylphosphatase family
G4Z16_RS08030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Z16_RS08035	COG0571	ribonuclease III activity
G4Z16_RS08040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4Z16_RS08055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4Z16_RS08060	COG0742	ribosomal rna small subunit methyltransferase
G4Z16_RS08070	COG1461	Dihydroxyacetone kinase
G4Z16_RS08075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Z16_RS08080	COG0351	phosphomethylpyrimidine kinase
G4Z16_RS08100	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Z16_RS08105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4Z16_RS08115	COG1920	GTP binding
G4Z16_RS08125	COG0776	regulation of translation
G4Z16_RS08135	COG0066	3-isopropylmalate dehydratase activity
G4Z16_RS08140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4Z16_RS08145	COG1414	Transcriptional regulator
G4Z16_RS08155	COG0789	Transcriptional regulator
G4Z16_RS08175	COG0456	acetyltransferase
G4Z16_RS08175	COG1846	Transcriptional regulator
G4Z16_RS08180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Z16_RS08185	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Z16_RS08200	COG2018	Roadblock/LC7 domain
G4Z16_RS08220	COG2018	Roadblock/LC7 domain
G4Z16_RS08240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Z16_RS08250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Z16_RS08255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Z16_RS08260	COG0473	3-isopropylmalate dehydrogenase activity
G4Z16_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS08280	COG0506	proline dehydrogenase activity
G4Z16_RS08310	COG2318	DinB family
G4Z16_RS08325	COG4977	sequence-specific DNA binding
G4Z16_RS08340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4Z16_RS08345	COG0440	acetolactate synthase activity
G4Z16_RS08365	COG0667	Aldo Keto reductase
G4Z16_RS08370	COG2133	pyrroloquinoline quinone binding
G4Z16_RS08385	COG1672	PFAM Archaeal ATPase
G4Z16_RS08385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G4Z16_RS08400	COG2409	Drug exporters of the RND superfamily
G4Z16_RS08405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4Z16_RS08415	COG0154	amidase activity
G4Z16_RS08420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4Z16_RS08430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Z16_RS08440	COG4221	oxidoreductase activity
G4Z16_RS08455	COG1611	Belongs to the LOG family
G4Z16_RS08460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Z16_RS08460	COG4651	solute:proton antiporter activity
G4Z16_RS08470	COG1077	Cell shape determining protein MreB Mrl
G4Z16_RS08475	COG0482	sulfurtransferase activity
G4Z16_RS08495	COG0076	glutamate decarboxylase activity
G4Z16_RS08500	COG2211	Major facilitator Superfamily
G4Z16_RS08525	COG0783	Belongs to the Dps family
G4Z16_RS08535	COG3594	Acyltransferase
G4Z16_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS08580	COG0583	DNA-binding transcription factor activity
G4Z16_RS08605	COG4608	Belongs to the ABC transporter superfamily
G4Z16_RS08610	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS08615	COG0601	transmembrane transport
G4Z16_RS08620	COG0747	negative chemotaxis
G4Z16_RS08645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4Z16_RS08650	COG0509	glycine decarboxylation via glycine cleavage system
G4Z16_RS08655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4Z16_RS08660	COG1760	l-serine dehydratase
G4Z16_RS08675	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS08685	COG2182	Extracellular solute-binding protein
G4Z16_RS08690	COG1175	transmembrane transport
G4Z16_RS08695	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS08700	COG1609	Transcriptional regulator
G4Z16_RS08730	COG1132	(ABC) transporter
G4Z16_RS08735	COG1132	(ABC) transporter
G4Z16_RS08745	COG0058	SHG alpha-glucan phosphorylase activity
G4Z16_RS08760	COG0366	Alpha amylase catalytic
G4Z16_RS08765	COG0366	Alpha amylase catalytic
G4Z16_RS08770	COG3281	Trehalose synthase
G4Z16_RS08775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4Z16_RS08780	COG1301	dicarboxylic acid transport
G4Z16_RS08785	COG3290	protein histidine kinase activity
G4Z16_RS08790	COG4565	transcriptional regulatory protein
G4Z16_RS08795	COG3469	chitinase activity
G4Z16_RS08805	COG1175	transmembrane transport
G4Z16_RS08810	COG3833	ABC-type maltose transport systems, permease component
G4Z16_RS08825	COG0205	6-phosphofructokinase activity
G4Z16_RS08830	COG0857	belongs to the CobB CobQ family
G4Z16_RS08830	COG0280	phosphate acetyltransferase
G4Z16_RS08835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4Z16_RS08875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS08875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS08885	COG1846	Transcriptional regulator
G4Z16_RS08945	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS08960	COG0183	Belongs to the thiolase family
G4Z16_RS08965	COG0346	lactoylglutathione lyase activity
G4Z16_RS08980	COG1131	(ABC) transporter
G4Z16_RS09005	COG3383	formate dehydrogenase (NAD+) activity
G4Z16_RS09005	COG0243	molybdopterin cofactor binding
G4Z16_RS09010	COG0437	4 iron, 4 sulfur cluster binding
G4Z16_RS09020	COG0488	(ABC) transporter
G4Z16_RS09040	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
G4Z16_RS09045	COG1024	Enoyl-CoA hydratase
G4Z16_RS09045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4Z16_RS09060	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS09065	COG0531	amino acid
G4Z16_RS09075	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z16_RS09105	COG4585	Histidine kinase
G4Z16_RS09110	COG2197	response regulator
G4Z16_RS09130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4Z16_RS09135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4Z16_RS09140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4Z16_RS09145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Z16_RS09150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Z16_RS09155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4Z16_RS09160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Z16_RS09180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Z16_RS09190	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Z16_RS09195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4Z16_RS09200	COG0254	rRNA binding
G4Z16_RS09205	COG1316	TRANSCRIPTIONal
G4Z16_RS09215	COG0083	homoserine kinase activity
G4Z16_RS09220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Z16_RS09225	COG0460	homoserine dehydrogenase
G4Z16_RS09230	COG0019	diaminopimelate decarboxylase activity
G4Z16_RS09235	COG0018	arginyl-trna synthetase
G4Z16_RS09320	COG3903	Transcriptional regulator
G4Z16_RS09320	COG3629	intracellular signal transduction
G4Z16_RS09350	COG4585	Histidine kinase
G4Z16_RS09355	COG2197	response regulator
G4Z16_RS09360	COG1271	oxidase subunit
G4Z16_RS09370	COG4988	ABC transporter
G4Z16_RS09375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4Z16_RS09395	COG3848	Pyruvate phosphate dikinase
G4Z16_RS09395	COG0574	Belongs to the PEP-utilizing enzyme family
G4Z16_RS09455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Z16_RS09495	COG2010	Cytochrome c
G4Z16_RS09495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS09500	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS09510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Z16_RS09515	COG0330	HflC and HflK could
G4Z16_RS09520	COG2182	Extracellular solute-binding protein
G4Z16_RS09525	COG1175	transmembrane transport
G4Z16_RS09530	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS09565	COG2356	endonuclease I
G4Z16_RS09590	COG1191	sigma factor activity
G4Z16_RS09690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4Z16_RS09705	COG2205	protein histidine kinase activity
G4Z16_RS09710	COG0567	Dehydrogenase, E1 component
G4Z16_RS09710	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Z16_RS09735	COG2255	four-way junction helicase activity
G4Z16_RS09770	COG0477	Major facilitator Superfamily
G4Z16_RS09775	COG0028	Belongs to the TPP enzyme family
G4Z16_RS09800	COG0604	alcohol dehydrogenase
G4Z16_RS09805	COG1126	abc transporter atp-binding protein
G4Z16_RS09810	COG0765	amino acid transport
G4Z16_RS09815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z16_RS09820	COG0281	malic enzyme
G4Z16_RS09825	COG4106	trans-aconitate 2-methyltransferase activity
G4Z16_RS09855	COG5006	permease, DMT superfamily
G4Z16_RS09860	COG0583	DNA-binding transcription factor activity
G4Z16_RS09915	COG1597	lipid kinase activity
G4Z16_RS09930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Z16_RS09935	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z16_RS09940	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS09945	COG1175	transmembrane transport
G4Z16_RS09950	COG2182	Extracellular solute-binding protein
G4Z16_RS09955	COG2188	Transcriptional regulator
G4Z16_RS09980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Z16_RS09995	COG0242	peptide deformylase activity
G4Z16_RS10010	COG2199	diguanylate cyclase activity
G4Z16_RS10010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G4Z16_RS10020	COG1595	DNA-templated transcription, initiation
G4Z16_RS10030	COG2135	peptidase activity
G4Z16_RS10040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4Z16_RS10045	COG1162	GTPase activity
G4Z16_RS10050	COG2076	Multidrug Resistance protein
G4Z16_RS10060	COG0483	inositol monophosphate 1-phosphatase activity
G4Z16_RS10070	COG0753	catalase activity
G4Z16_RS10095	COG1615	UPF0182 protein
G4Z16_RS10105	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4Z16_RS10185	COG0210	DNA helicase
G4Z16_RS10265	COG0513	Belongs to the DEAD box helicase family
G4Z16_RS10270	COG0596	Alpha beta hydrolase
G4Z16_RS10275	COG0613	PHP domain protein
G4Z16_RS10290	COG0598	Magnesium transport protein CorA
G4Z16_RS10305	COG2239	Acts as a magnesium transporter
G4Z16_RS10325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4Z16_RS10335	COG1595	DNA-templated transcription, initiation
G4Z16_RS10350	COG1024	Enoyl-CoA hydratase
G4Z16_RS10355	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z16_RS10365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4Z16_RS10370	COG1611	Belongs to the LOG family
G4Z16_RS10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z16_RS10420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Z16_RS10435	COG4608	Belongs to the ABC transporter superfamily
G4Z16_RS10440	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS10445	COG0601	transmembrane transport
G4Z16_RS10450	COG4166	transmembrane transport
G4Z16_RS10455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Z16_RS10465	COG4608	Belongs to the ABC transporter superfamily
G4Z16_RS10470	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS10480	COG0601	transmembrane transport
G4Z16_RS10485	COG4166	transmembrane transport
G4Z16_RS10490	COG1217	gtp-binding protein TYPA
G4Z16_RS10500	COG0456	acetyltransferase
G4Z16_RS10500	COG0454	-acetyltransferase
G4Z16_RS10520	COG1053	succinate dehydrogenase
G4Z16_RS10530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z16_RS10540	COG3829	transcription factor binding
G4Z16_RS10540	COG3290	protein histidine kinase activity
G4Z16_RS10560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Z16_RS10565	COG0582	viral genome integration into host DNA
G4Z16_RS10595	COG0012	GTP binding
G4Z16_RS10605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4Z16_RS10610	COG1570	exodeoxyribonuclease VII activity
G4Z16_RS10615	COG1722	exodeoxyribonuclease VII activity
G4Z16_RS10620	COG0778	Nitroreductase
G4Z16_RS10650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4Z16_RS10650	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4Z16_RS10655	COG0114	fumarate hydratase activity
G4Z16_RS10675	COG2197	response regulator
G4Z16_RS10685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Z16_RS10720	COG1136	(ABC) transporter
G4Z16_RS10755	COG0741	lytic transglycosylase activity
G4Z16_RS10760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4Z16_RS10765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4Z16_RS10770	COG0667	Aldo Keto reductase
G4Z16_RS10780	COG2885	chlorophyll binding
G4Z16_RS10820	COG2894	cell division
G4Z16_RS10850	COG2610	gluconate transmembrane transporter activity
G4Z16_RS10855	COG0251	oxidation-reduction process
G4Z16_RS10860	COG1414	Transcriptional regulator
G4Z16_RS10875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G4Z16_RS10885	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G4Z16_RS10895	COG0436	Aminotransferase
G4Z16_RS10900	COG0477	Major facilitator Superfamily
G4Z16_RS10910	COG1331	Highly conserved protein containing a thioredoxin domain
G4Z16_RS10940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4Z16_RS10955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Z16_RS10965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Z16_RS10975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4Z16_RS11005	COG0248	Ppx GppA phosphatase
G4Z16_RS11030	COG0471	metal ion transport
G4Z16_RS11045	COG0740	serine-type endopeptidase activity
G4Z16_RS11050	COG0740	serine-type endopeptidase activity
G4Z16_RS11060	COG2318	DinB family
G4Z16_RS11085	COG2814	Major facilitator Superfamily
G4Z16_RS11090	COG0693	protein deglycase activity
G4Z16_RS11110	COG2986	histidine ammonia-lyase
G4Z16_RS11120	COG1024	Enoyl-CoA hydratase
G4Z16_RS11125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G4Z16_RS11135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Z16_RS11150	COG0424	maF-like protein
G4Z16_RS11160	COG4770	biotin carboxylase activity
G4Z16_RS11185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Z16_RS11215	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS11250	COG1595	DNA-templated transcription, initiation
G4Z16_RS11255	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS11260	COG2205	protein histidine kinase activity
G4Z16_RS11285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G4Z16_RS11295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Z16_RS11305	COG0583	DNA-binding transcription factor activity
G4Z16_RS11310	COG2814	Major facilitator Superfamily
G4Z16_RS11330	COG1079	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS11335	COG4603	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS11340	COG3845	ABC transporter
G4Z16_RS11345	COG1744	ABC transporter substrate-binding protein PnrA-like
G4Z16_RS11350	COG1473	amidohydrolase
G4Z16_RS11350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4Z16_RS11360	COG2089	acid synthase
G4Z16_RS11365	COG1083	cytidylyl-transferase
G4Z16_RS11375	COG1216	Glycosyl transferase, family 2
G4Z16_RS11390	COG3265	gluconokinase activity
G4Z16_RS11395	COG2186	Transcriptional regulator
G4Z16_RS11425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS11425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS11440	COG1595	DNA-templated transcription, initiation
G4Z16_RS11445	COG3064	Membrane
G4Z16_RS11445	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G4Z16_RS11445	COG3583	domain protein
G4Z16_RS11455	COG2009	succinate dehydrogenase
G4Z16_RS11465	COG1053	succinate dehydrogenase
G4Z16_RS11490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Z16_RS11495	COG0180	Tryptophanyl-tRNA synthetase
G4Z16_RS11510	COG1686	Belongs to the peptidase S11 family
G4Z16_RS11520	COG1408	metallophosphoesterase
G4Z16_RS11525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4Z16_RS11540	COG0517	IMP dehydrogenase activity
G4Z16_RS11540	COG4175	Glycine betaine
G4Z16_RS11550	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS11570	COG0039	L-malate dehydrogenase activity
G4Z16_RS11585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4Z16_RS11610	COG0138	bifunctional purine biosynthesis protein purh
G4Z16_RS11640	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Z16_RS11665	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G4Z16_RS11670	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G4Z16_RS11675	COG0714	Associated with various cellular activities
G4Z16_RS11690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Z16_RS11695	COG0739	heme binding
G4Z16_RS11695	COG0741	lytic transglycosylase activity
G4Z16_RS11695	COG1196	nuclear chromosome segregation
G4Z16_RS11745	COG2197	response regulator
G4Z16_RS11760	COG0667	Aldo Keto reductase
G4Z16_RS11775	COG2318	DinB family
G4Z16_RS11785	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z16_RS11785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Z16_RS11800	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS11810	COG2815	serine threonine protein kinase
G4Z16_RS11810	COG0515	serine threonine protein kinase
G4Z16_RS11815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4Z16_RS11830	COG0516	GMP reductase activity
G4Z16_RS11840	COG1595	DNA-templated transcription, initiation
G4Z16_RS11860	COG4221	oxidoreductase activity
G4Z16_RS11870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4Z16_RS11885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4Z16_RS11915	COG0802	atpase or kinase
G4Z16_RS11925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4Z16_RS11935	COG0736	holo-[acyl-carrier-protein] synthase activity
G4Z16_RS11940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Z16_RS11950	COG1072	(Pantothenic acid kinase))
G4Z16_RS11955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Z16_RS11960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4Z16_RS11965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4Z16_RS11970	COG0488	(ABC) transporter
G4Z16_RS11980	COG0101	tRNA pseudouridine synthase activity
G4Z16_RS11990	COG0202	RNA polymerase activity
G4Z16_RS11995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4Z16_RS12000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4Z16_RS12005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4Z16_RS12010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4Z16_RS12015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4Z16_RS12025	COG0563	adenylate kinase activity
G4Z16_RS12035	COG0200	Binds to the 23S rRNA
G4Z16_RS12045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4Z16_RS12050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4Z16_RS12055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4Z16_RS12060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4Z16_RS12065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4Z16_RS12070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Z16_RS12075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4Z16_RS12080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4Z16_RS12085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4Z16_RS12090	COG0255	Belongs to the universal ribosomal protein uL29 family
G4Z16_RS12095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4Z16_RS12100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4Z16_RS12105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4Z16_RS12110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4Z16_RS12115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Z16_RS12120	COG0089	rRNA binding
G4Z16_RS12125	COG0088	Forms part of the polypeptide exit tunnel
G4Z16_RS12130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4Z16_RS12135	COG0051	transcription antitermination factor activity, RNA binding
G4Z16_RS12140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Z16_RS12160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G4Z16_RS12165	COG2353	YceI-like domain
G4Z16_RS12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Z16_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Z16_RS12180	COG0049	tRNA binding
G4Z16_RS12185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4Z16_RS12195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4Z16_RS12200	COG0085	RNA polymerase activity
G4Z16_RS12205	COG0222	ribosome binding
G4Z16_RS12210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4Z16_RS12220	COG0081	regulation of translation
G4Z16_RS12225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G4Z16_RS12240	COG2188	Transcriptional regulator
G4Z16_RS12265	COG0582	viral genome integration into host DNA
G4Z16_RS12270	COG0250	Participates in transcription elongation, termination and antitermination
G4Z16_RS12285	COG0436	Aminotransferase
G4Z16_RS12290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G4Z16_RS12305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4Z16_RS12315	COG2030	dehydratase
G4Z16_RS12320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4Z16_RS12340	COG0702	epimerase
G4Z16_RS12345	COG1295	ribonuclease BN
G4Z16_RS12385	COG1666	GTP binding
G4Z16_RS12390	COG0501	Belongs to the peptidase M48B family
G4Z16_RS12395	COG1007	ATP synthesis coupled electron transport
G4Z16_RS12410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Z16_RS12415	COG0713	ATP synthesis coupled electron transport
G4Z16_RS12420	COG0839	Belongs to the complex I subunit 6 family
G4Z16_RS12425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4Z16_RS12435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12455	COG4585	Histidine kinase
G4Z16_RS12460	COG4585	Histidine kinase
G4Z16_RS12470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4Z16_RS12470	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4Z16_RS12475	COG1013	pyruvate-flavodoxin oxidoreductase activity
G4Z16_RS12490	COG1131	(ABC) transporter
G4Z16_RS12500	COG0142	geranyltranstransferase activity
G4Z16_RS12505	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Z16_RS12515	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS12535	COG1007	ATP synthesis coupled electron transport
G4Z16_RS12545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Z16_RS12550	COG0713	ATP synthesis coupled electron transport
G4Z16_RS12555	COG0839	Belongs to the complex I subunit 6 family
G4Z16_RS12560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4Z16_RS12570	COG1034	ATP synthesis coupled electron transport
G4Z16_RS12575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4Z16_RS12585	COG0649	NAD binding
G4Z16_RS12590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS12605	COG3103	Sh3 type 3 domain protein
G4Z16_RS12605	COG0791	NLP P60 protein
G4Z16_RS12605	COG1388	LysM domain
G4Z16_RS12630	COG2226	methyltransferase
G4Z16_RS12640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4Z16_RS12645	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G4Z16_RS12650	COG1278	Cold shock
G4Z16_RS12655	COG2376	Dihydroxyacetone kinase
G4Z16_RS12665	COG0739	heme binding
G4Z16_RS12675	COG3246	L-lysine catabolic process to acetate
G4Z16_RS12680	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS12685	COG0824	Thioesterase
G4Z16_RS12685	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Z16_RS12690	COG2175	clavaminate synthase activity
G4Z16_RS12715	COG0183	Belongs to the thiolase family
G4Z16_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS12730	COG1309	transcriptional regulator
G4Z16_RS12740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4Z16_RS12775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Z16_RS12805	COG0789	Transcriptional regulator
G4Z16_RS12820	COG5564	TIM-barrel signal transduction protein
G4Z16_RS12850	COG0596	Alpha beta hydrolase
G4Z16_RS12870	COG4555	ABC transporter
G4Z16_RS12880	COG2197	response regulator
G4Z16_RS12890	COG0596	Alpha beta hydrolase
G4Z16_RS12895	COG1301	dicarboxylic acid transport
G4Z16_RS12900	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS12910	COG1301	dicarboxylic acid transport
G4Z16_RS12935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4Z16_RS12945	COG0728	peptidoglycan biosynthetic process
G4Z16_RS12955	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS12985	COG1573	uracil-dna glycosylase
G4Z16_RS12990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4Z16_RS13000	COG0163	prenyltransferase activity
G4Z16_RS13020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G4Z16_RS13030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4Z16_RS13035	COG1333	cytochrome c biogenesis protein
G4Z16_RS13040	COG0785	Cytochrome C biogenesis protein
G4Z16_RS13050	COG0406	alpha-ribazole phosphatase activity
G4Z16_RS13055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4Z16_RS13080	COG1620	l-lactate permease
G4Z16_RS13090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4Z16_RS13095	COG1742	UPF0060 membrane protein
G4Z16_RS13105	COG1690	Belongs to the RtcB family
G4Z16_RS13125	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G4Z16_RS13130	COG0018	arginyl-trna synthetase
G4Z16_RS13160	COG1072	(Pantothenic acid kinase))
G4Z16_RS13170	COG0113	porphobilinogen synthase activity
G4Z16_RS13175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Z16_RS13175	COG1648	precorrin-2 dehydrogenase activity
G4Z16_RS13180	COG0181	hydroxymethylbilane synthase activity
G4Z16_RS13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4Z16_RS13190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4Z16_RS13205	COG1595	DNA-templated transcription, initiation
G4Z16_RS13240	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4Z16_RS13245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Z16_RS13265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4Z16_RS13275	COG0842	Transport permease protein
G4Z16_RS13275	COG1129	ABC transporter
G4Z16_RS13295	COG0129	dihydroxy-acid dehydratase activity
G4Z16_RS13305	COG1082	Xylose isomerase domain protein TIM barrel
G4Z16_RS13310	COG0248	Ppx GppA phosphatase
G4Z16_RS13330	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G4Z16_RS13340	COG1194	a g-specific adenine glycosylase
G4Z16_RS13355	COG0477	Major facilitator Superfamily
G4Z16_RS13365	COG0739	heme binding
G4Z16_RS13395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4Z16_RS13410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4Z16_RS13415	COG0157	Belongs to the NadC ModD family
G4Z16_RS13420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4Z16_RS13425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4Z16_RS13440	COG2197	response regulator
G4Z16_RS13465	COG0649	NAD binding
G4Z16_RS13480	COG1174	glycine betaine transport
G4Z16_RS13485	COG1174	glycine betaine transport
G4Z16_RS13490	COG0517	IMP dehydrogenase activity
G4Z16_RS13490	COG1125	glycine betaine transport
G4Z16_RS13515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4Z16_RS13520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4Z16_RS13530	COG0302	gtp cyclohydrolase
G4Z16_RS13545	COG0037	tRNA processing
G4Z16_RS13555	COG2027	D-alanyl-D-alanine carboxypeptidase
G4Z16_RS13560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4Z16_RS13585	COG2318	DinB family
G4Z16_RS13590	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS13610	COG1132	(ABC) transporter
G4Z16_RS13615	COG1077	Cell shape determining protein MreB Mrl
G4Z16_RS13625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4Z16_RS13710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Z16_RS13740	COG2197	response regulator
G4Z16_RS13750	COG0596	Alpha beta hydrolase
G4Z16_RS13800	COG0494	nUDIX hydrolase
G4Z16_RS13885	COG0305	Participates in initiation and elongation during chromosome replication
G4Z16_RS13935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4Z16_RS13940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4Z16_RS13945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Z16_RS13945	COG1754	DNA topoisomerase type I activity
G4Z16_RS13960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Z16_RS13965	COG2172	sigma factor antagonist activity
G4Z16_RS13970	COG1366	Belongs to the anti-sigma-factor antagonist family
G4Z16_RS13975	COG1205	dead DEAH box helicase
G4Z16_RS13975	COG1111	helicase
G4Z16_RS14035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4Z16_RS14045	COG0596	Alpha beta hydrolase
G4Z16_RS14060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Z16_RS14070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Z16_RS14095	COG0003	Pfam Anion-transporting ATPase
G4Z16_RS14115	COG1408	metallophosphoesterase
G4Z16_RS14135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Z16_RS14135	COG0515	serine threonine protein kinase
G4Z16_RS14155	COG2801	Transposase and inactivated derivatives
G4Z16_RS14155	COG3415	Transposase
G4Z16_RS14190	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4Z16_RS14205	COG2770	Histidine kinase
G4Z16_RS14205	COG2208	phosphoserine phosphatase activity
G4Z16_RS14210	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS14215	COG2264	protein methyltransferase activity
G4Z16_RS14220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4Z16_RS14235	COG0531	amino acid
G4Z16_RS14245	COG0154	amidase activity
G4Z16_RS14265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G4Z16_RS14270	COG2986	histidine ammonia-lyase
G4Z16_RS14305	COG1834	amidinotransferase
G4Z16_RS14310	COG0583	DNA-binding transcription factor activity
G4Z16_RS14330	COG1733	regulation of RNA biosynthetic process
G4Z16_RS14335	COG0604	alcohol dehydrogenase
G4Z16_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS14335	COG3321	synthase
G4Z16_RS14435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Z16_RS14440	COG2124	cytochrome p450
G4Z16_RS14450	COG2226	methyltransferase
G4Z16_RS14490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4Z16_RS14535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4Z16_RS14540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4Z16_RS14570	COG0515	serine threonine protein kinase
G4Z16_RS14570	COG2815	serine threonine protein kinase
G4Z16_RS14585	COG2814	Major facilitator Superfamily
G4Z16_RS14590	COG1414	Transcriptional regulator
G4Z16_RS14625	COG1063	alcohol dehydrogenase
G4Z16_RS14630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Z16_RS14660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS14670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4Z16_RS14675	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS14680	COG2205	protein histidine kinase activity
G4Z16_RS14700	COG3594	Acyltransferase
G4Z16_RS14705	COG2234	aminopeptidase activity
G4Z16_RS14720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4Z16_RS14735	COG0590	tRNA wobble adenosine to inosine editing
G4Z16_RS14750	COG3903	Transcriptional regulator
G4Z16_RS14750	COG3629	intracellular signal transduction
G4Z16_RS14755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Z16_RS14760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Z16_RS14770	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS14780	COG0297	glycogen (starch) synthase activity
G4Z16_RS14805	COG0583	DNA-binding transcription factor activity
G4Z16_RS14830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Z16_RS14835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS14850	COG1191	sigma factor activity
G4Z16_RS14855	COG1191	sigma factor activity
G4Z16_RS14870	COG2353	YceI-like domain
G4Z16_RS14880	COG0739	heme binding
G4Z16_RS14895	COG0604	alcohol dehydrogenase
G4Z16_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS14895	COG3321	synthase
G4Z16_RS14915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS14920	COG1414	Transcriptional regulator
G4Z16_RS14925	COG2814	Major facilitator Superfamily
G4Z16_RS14930	COG0402	S-adenosylhomocysteine deaminase activity
G4Z16_RS14935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4Z16_RS14955	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G4Z16_RS14960	COG4251	negative regulation of phosphorylation
G4Z16_RS14985	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS14990	COG1595	DNA-templated transcription, initiation
G4Z16_RS15010	COG1609	Transcriptional regulator
G4Z16_RS15015	COG1653	transport
G4Z16_RS15030	COG0366	Alpha amylase catalytic
G4Z16_RS15035	COG0366	Alpha amylase catalytic
G4Z16_RS15065	COG0477	Major facilitator Superfamily
G4Z16_RS15075	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS15110	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS15115	COG1175	transmembrane transport
G4Z16_RS15125	COG1940	carbohydrate kinase activity
G4Z16_RS15130	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS15140	COG1454	alcohol dehydrogenase
G4Z16_RS15145	COG0473	3-isopropylmalate dehydrogenase activity
G4Z16_RS15150	COG1053	succinate dehydrogenase
G4Z16_RS15185	COG0583	DNA-binding transcription factor activity
G4Z16_RS15190	COG3214	Protein conserved in bacteria
G4Z16_RS15220	COG4941	Belongs to the sigma-70 factor family
G4Z16_RS15225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4Z16_RS15235	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS15245	COG1295	ribonuclease BN
G4Z16_RS15285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS15295	COG2208	phosphoserine phosphatase activity
G4Z16_RS15350	COG0473	3-isopropylmalate dehydrogenase activity
G4Z16_RS15350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4Z16_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS15360	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4Z16_RS15380	COG0587	DNA-directed DNA polymerase activity
G4Z16_RS15450	COG2188	Transcriptional regulator
G4Z16_RS15460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Z16_RS15475	COG2186	Transcriptional regulator
G4Z16_RS15520	COG0305	Participates in initiation and elongation during chromosome replication
G4Z16_RS15630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Z16_RS15645	COG0653	protein targeting
G4Z16_RS15665	COG0006	proline dipeptidase activity
G4Z16_RS15690	COG1999	signal sequence binding
G4Z16_RS15700	COG2372	response to copper ion
G4Z16_RS15720	COG2378	regulation of single-species biofilm formation
G4Z16_RS15725	COG0561	phosphatase activity
G4Z16_RS15730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4Z16_RS15745	COG1131	(ABC) transporter
G4Z16_RS15755	COG1131	(ABC) transporter
G4Z16_RS15790	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G4Z16_RS15795	COG3046	protein related to deoxyribodipyrimidine photolyase
G4Z16_RS15805	COG0501	Belongs to the peptidase M48B family
G4Z16_RS15815	COG4988	ABC transporter
G4Z16_RS15820	COG1294	oxidase, subunit
G4Z16_RS15825	COG1271	oxidase subunit
G4Z16_RS15830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Z16_RS15835	COG1609	Transcriptional regulator
G4Z16_RS15840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Z16_RS15855	COG3415	Transposase
G4Z16_RS15855	COG2801	Transposase and inactivated derivatives
G4Z16_RS15860	COG0626	cystathionine gamma-synthase activity
G4Z16_RS15865	COG3001	Fructosamine kinase
G4Z16_RS15870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Z16_RS15875	COG1950	PFAM Membrane protein of
G4Z16_RS15880	COG0662	Cupin 2, conserved barrel domain protein
G4Z16_RS15895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4Z16_RS15920	COG1414	Transcriptional regulator
G4Z16_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS15940	COG1301	dicarboxylic acid transport
G4Z16_RS15975	COG2814	Major facilitator Superfamily
G4Z16_RS15980	COG1846	Transcriptional regulator
G4Z16_RS16050	COG0305	Participates in initiation and elongation during chromosome replication
G4Z16_RS16055	COG0534	Mate efflux family protein
G4Z16_RS16060	COG0359	binds to the 23S rRNA
G4Z16_RS16065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Z16_RS16070	COG0629	single-stranded DNA binding
G4Z16_RS16075	COG0360	Binds together with S18 to 16S ribosomal RNA
G4Z16_RS16095	COG0477	Major facilitator Superfamily
G4Z16_RS16120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Z16_RS16135	COG0617	tRNA 3'-terminal CCA addition
G4Z16_RS16155	COG1595	DNA-templated transcription, initiation
G4Z16_RS16165	COG0492	ferredoxin-NADP+ reductase activity
G4Z16_RS16170	COG3118	belongs to the thioredoxin family
G4Z16_RS16190	COG0357	Ribosomal RNA small subunit methyltransferase G
G4Z16_RS16200	COG0706	membrane insertase activity
G4Z16_RS16205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4Z16_RS16215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4Z16_RS16220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4Z16_RS16225	COG0592	DNA-directed DNA polymerase activity
G4Z16_RS16230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4Z16_RS16235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Z16_RS16240	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
G4Z16_RS16250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Z16_RS16280	COG0181	hydroxymethylbilane synthase activity
G4Z16_RS16305	COG0515	serine threonine protein kinase
G4Z16_RS16325	COG2409	Drug exporters of the RND superfamily
G4Z16_RS16340	COG0705	Rhomboid family
G4Z16_RS16365	COG3764	Sortase (surface protein transpeptidase)
G4Z16_RS16370	COG3764	Sortase (surface protein transpeptidase)
G4Z16_RS16375	COG0515	serine threonine protein kinase
G4Z16_RS16385	COG0772	Belongs to the SEDS family
G4Z16_RS16395	COG1716	ATPase activity
G4Z16_RS16400	COG1716	ATPase activity
G4Z16_RS16510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4Z16_RS16515	COG1733	regulation of RNA biosynthetic process
G4Z16_RS16530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4Z16_RS16535	COG2151	metal-sulfur cluster biosynthetic enzyme
G4Z16_RS16540	COG3396	Phenylacetate-CoA oxygenase
G4Z16_RS16545	COG3460	Phenylacetate-CoA oxygenase
G4Z16_RS16550	COG3396	Phenylacetate-CoA oxygenase
G4Z16_RS16585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Z16_RS16590	COG0303	'Molybdopterin
G4Z16_RS16600	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Z16_RS16615	COG1522	sequence-specific DNA binding
G4Z16_RS16620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4Z16_RS16630	COG4608	Belongs to the ABC transporter superfamily
G4Z16_RS16635	COG0444	Belongs to the ABC transporter superfamily
G4Z16_RS16640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Z16_RS16645	COG0601	transmembrane transport
G4Z16_RS16655	COG0277	FAD linked oxidase domain protein
G4Z16_RS16670	COG0515	serine threonine protein kinase
G4Z16_RS16675	COG0515	serine threonine protein kinase
G4Z16_RS16690	COG0022	dehydrogenase e1 component
G4Z16_RS16695	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Z16_RS16725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Z16_RS16735	COG1362	aminopeptidase activity
G4Z16_RS16740	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS16755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4Z16_RS16765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4Z16_RS16815	COG1252	NADH dehydrogenase
G4Z16_RS16825	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS16830	COG1175	transmembrane transport
G4Z16_RS16845	COG1609	Transcriptional regulator
G4Z16_RS16850	COG3321	synthase
G4Z16_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS16850	COG0604	alcohol dehydrogenase
G4Z16_RS16855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Z16_RS16860	COG4585	Histidine kinase
G4Z16_RS16865	COG2197	response regulator
G4Z16_RS16880	COG4336	lyase activity
G4Z16_RS16885	COG2814	Major facilitator Superfamily
G4Z16_RS16910	COG1802	Transcriptional regulator
G4Z16_RS16940	COG5002	protein histidine kinase activity
G4Z16_RS16945	COG2018	Roadblock/LC7 domain
G4Z16_RS16965	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS16975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS16985	COG2186	Transcriptional regulator
G4Z16_RS17000	COG3290	protein histidine kinase activity
G4Z16_RS17010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Z16_RS17090	COG3415	Transposase
G4Z16_RS17090	COG2801	Transposase and inactivated derivatives
G4Z16_RS17105	COG2226	methyltransferase
G4Z16_RS17145	COG1725	Transcriptional regulator
G4Z16_RS17150	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G4Z16_RS17155	COG1388	LysM domain
G4Z16_RS17155	COG3584	3D domain protein
G4Z16_RS17165	COG3511	phospholipase C
G4Z16_RS17185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS17200	COG2318	DinB family
G4Z16_RS17215	COG0596	Alpha beta hydrolase
G4Z16_RS17230	COG2814	Major facilitator Superfamily
G4Z16_RS17255	COG0477	Major facilitator Superfamily
G4Z16_RS17295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS17300	COG1215	transferase activity, transferring glycosyl groups
G4Z16_RS17305	COG1316	TRANSCRIPTIONal
G4Z16_RS17355	COG2188	Transcriptional regulator
G4Z16_RS17405	COG0717	Belongs to the dCTP deaminase family
G4Z16_RS17440	COG0247	lactate metabolic process
G4Z16_RS17440	COG2181	nitrate reductase activity
G4Z16_RS17445	COG0443	Heat shock 70 kDa protein
G4Z16_RS17450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Z16_RS17455	COG0484	heat shock protein binding
G4Z16_RS17460	COG0789	Transcriptional regulator
G4Z16_RS17485	COG0542	response to heat
G4Z16_RS17505	COG2208	phosphoserine phosphatase activity
G4Z16_RS17505	COG1366	Belongs to the anti-sigma-factor antagonist family
G4Z16_RS17505	COG2172	sigma factor antagonist activity
G4Z16_RS17525	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G4Z16_RS17540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4Z16_RS17545	COG0191	fructose-bisphosphate aldolase activity
G4Z16_RS17560	COG3844	kynureninase activity
G4Z16_RS17575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4Z16_RS17605	COG1131	(ABC) transporter
G4Z16_RS17610	COG3559	Exporter of polyketide antibiotics
G4Z16_RS17615	COG0515	serine threonine protein kinase
G4Z16_RS17615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Z16_RS17630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Z16_RS17635	COG1802	Transcriptional regulator
G4Z16_RS17650	COG0151	Belongs to the GarS family
G4Z16_RS17665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G4Z16_RS17680	COG1132	(ABC) transporter
G4Z16_RS17685	COG2226	methyltransferase
G4Z16_RS17710	COG2197	response regulator
G4Z16_RS17745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4Z16_RS17750	COG0047	phosphoribosylformylglycinamidine synthase activity
G4Z16_RS17755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4Z16_RS17765	COG0473	3-isopropylmalate dehydrogenase activity
G4Z16_RS17775	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS17780	COG1175	transmembrane transport
G4Z16_RS17790	COG1609	Transcriptional regulator
G4Z16_RS17805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G4Z16_RS17835	COG1643	Atp-dependent helicase
G4Z16_RS17860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Z16_RS17915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4Z16_RS17920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4Z16_RS17930	COG0513	Belongs to the DEAD box helicase family
G4Z16_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z16_RS17950	COG2271	Major facilitator Superfamily
G4Z16_RS17955	COG3835	regulator
G4Z16_RS18000	COG0372	Belongs to the citrate synthase family
G4Z16_RS18005	COG0372	Belongs to the citrate synthase family
G4Z16_RS18010	COG0789	Transcriptional regulator
G4Z16_RS18015	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS18030	COG0300	oxidoreductase activity
G4Z16_RS18050	COG1196	nuclear chromosome segregation
G4Z16_RS18050	COG0741	lytic transglycosylase activity
G4Z16_RS18050	COG0739	heme binding
G4Z16_RS18055	COG0667	Aldo Keto reductase
G4Z16_RS18060	COG3467	pyridoxamine 5'-phosphate
G4Z16_RS18085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Z16_RS18100	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
G4Z16_RS18105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4Z16_RS18110	COG0579	oxidoreductase
G4Z16_RS18140	COG1252	NADH dehydrogenase
G4Z16_RS18155	COG1846	Transcriptional regulator
G4Z16_RS18225	COG0739	heme binding
G4Z16_RS18225	COG0741	lytic transglycosylase activity
G4Z16_RS18225	COG1196	nuclear chromosome segregation
G4Z16_RS18230	COG0671	phosphoesterase, PA-phosphatase related
G4Z16_RS18250	COG1937	Protein conserved in bacteria
G4Z16_RS18260	COG0306	phosphate transporter
G4Z16_RS18265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4Z16_RS18280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Z16_RS18340	COG1309	transcriptional regulator
G4Z16_RS18345	COG0300	oxidoreductase activity
G4Z16_RS18375	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
G4Z16_RS18460	COG1032	radical SAM domain protein
G4Z16_RS18465	COG2814	Major facilitator Superfamily
G4Z16_RS18470	COG1247	-acetyltransferase
G4Z16_RS18475	COG3268	Saccharopine dehydrogenase
G4Z16_RS18480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4Z16_RS18485	COG0477	Major facilitator Superfamily
G4Z16_RS18490	COG1063	alcohol dehydrogenase
G4Z16_RS18505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Z16_RS18515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Z16_RS18540	COG2188	Transcriptional regulator
G4Z16_RS18550	COG4552	Acetyltransferase involved in intracellular survival and related
G4Z16_RS18560	COG2197	response regulator
G4Z16_RS18570	COG1131	(ABC) transporter
G4Z16_RS18585	COG1490	D-aminoacyl-tRNA deacylase activity
G4Z16_RS18610	COG3485	protocatechuate 3,4-dioxygenase
G4Z16_RS18625	COG2897	thiosulfate sulfurtransferase activity
G4Z16_RS18650	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS18655	COG1609	Transcriptional regulator
G4Z16_RS18660	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS18665	COG2205	protein histidine kinase activity
G4Z16_RS18675	COG0454	-acetyltransferase
G4Z16_RS18675	COG0456	acetyltransferase
G4Z16_RS18680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4Z16_RS18705	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS18740	COG0588	phosphoglycerate mutase activity
G4Z16_RS18755	COG5002	protein histidine kinase activity
G4Z16_RS18770	COG1329	Transcriptional regulator
G4Z16_RS18775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4Z16_RS18780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4Z16_RS18790	COG0215	cysteine-tRNA ligase activity
G4Z16_RS18805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Z16_RS18815	COG3842	ATPase activity
G4Z16_RS18865	COG0644	oxidoreductase
G4Z16_RS18870	COG3655	Transcriptional regulator
G4Z16_RS18895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4Z16_RS18910	COG2205	protein histidine kinase activity
G4Z16_RS18915	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS18955	COG1609	Transcriptional regulator
G4Z16_RS18960	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z16_RS18970	COG1175	transmembrane transport
G4Z16_RS18980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Z16_RS19000	COG1940	carbohydrate kinase activity
G4Z16_RS19030	COG2135	peptidase activity
G4Z16_RS19040	COG0443	Heat shock 70 kDa protein
G4Z16_RS19045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Z16_RS19060	COG0542	response to heat
G4Z16_RS19125	COG1105	Belongs to the carbohydrate kinase PfkB family
G4Z16_RS19160	COG3415	Transposase
G4Z16_RS19160	COG2801	Transposase and inactivated derivatives
G4Z16_RS19170	COG0463	Glycosyl transferase, family 2
G4Z16_RS19185	COG1278	Cold shock
G4Z16_RS19195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4Z16_RS19215	COG0477	Major facilitator Superfamily
G4Z16_RS19240	COG4257	antibiotic catabolic process
G4Z16_RS19245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G4Z16_RS19250	COG1309	transcriptional regulator
G4Z16_RS19260	COG1263	PTS System
G4Z16_RS19260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4Z16_RS19265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G4Z16_RS19270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G4Z16_RS19325	COG1609	Transcriptional regulator
G4Z16_RS19330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4Z16_RS19340	COG1090	epimerase
G4Z16_RS19355	COG3973	AAA domain
G4Z16_RS19365	COG1061	Type III restriction enzyme res subunit
G4Z16_RS19410	COG0546	phosphoglycolate phosphatase activity
G4Z16_RS19420	COG1278	Cold shock
G4Z16_RS19425	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G4Z16_RS19430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4Z16_RS19435	COG2814	Major facilitator Superfamily
G4Z16_RS19460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4Z16_RS19500	COG0667	Aldo Keto reductase
G4Z16_RS19510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4Z16_RS19530	COG0247	lactate metabolic process
G4Z16_RS19530	COG0277	FAD linked oxidase domain protein
G4Z16_RS19545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Z16_RS19560	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS19565	COG1024	Enoyl-CoA hydratase
G4Z16_RS19585	COG0789	Transcriptional regulator
G4Z16_RS19600	COG0259	pyridoxamine-phosphate oxidase activity
G4Z16_RS19610	COG4821	SIS domain
G4Z16_RS19675	COG4977	sequence-specific DNA binding
G4Z16_RS19700	COG2072	flavoprotein involved in K transport
G4Z16_RS19710	COG0515	serine threonine protein kinase
G4Z16_RS19710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4Z16_RS19730	COG2801	Transposase and inactivated derivatives
G4Z16_RS19730	COG3415	Transposase
G4Z16_RS19775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4Z16_RS19800	COG1686	Belongs to the peptidase S11 family
G4Z16_RS19825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4Z16_RS19875	COG3903	Transcriptional regulator
G4Z16_RS19875	COG3629	intracellular signal transduction
G4Z16_RS19880	COG0737	Belongs to the 5'-nucleotidase family
G4Z16_RS19895	COG2843	Capsule synthesis protein
G4Z16_RS19900	COG2197	response regulator
G4Z16_RS19905	COG4585	Histidine kinase
G4Z16_RS19955	COG0142	geranyltranstransferase activity
G4Z16_RS19970	COG2124	cytochrome p450
G4Z16_RS20005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4Z16_RS20025	COG1349	DNA-binding transcription factor activity
G4Z16_RS20030	COG1105	Belongs to the carbohydrate kinase PfkB family
G4Z16_RS20035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4Z16_RS20035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Z16_RS20035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4Z16_RS20040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Z16_RS20050	COG1309	transcriptional regulator
G4Z16_RS20070	COG0596	Alpha beta hydrolase
G4Z16_RS20075	COG0477	Major facilitator Superfamily
G4Z16_RS20105	COG1222	aaa ATPase
G4Z16_RS20325	COG0582	viral genome integration into host DNA
G4Z16_RS20350	COG1063	alcohol dehydrogenase
G4Z16_RS20360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Z16_RS20365	COG0657	acetylesterase activity
G4Z16_RS20405	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Z16_RS20410	COG0655	NAD(P)H dehydrogenase (quinone) activity
G4Z16_RS20420	COG3191	aminopeptidase activity
G4Z16_RS20430	COG1970	mechanosensitive ion channel activity
G4Z16_RS20440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4Z16_RS20455	COG3263	regulation of cellular component size
G4Z16_RS20465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4Z16_RS20470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4Z16_RS20480	COG0315	cyclic pyranopterin monophosphate synthase activity
G4Z16_RS20485	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4Z16_RS20490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Z16_RS20510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4Z16_RS20540	COG0151	Belongs to the GarS family
G4Z16_RS20575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Z16_RS20585	COG1953	Uracil, thiamine, allantoin
G4Z16_RS20590	COG1802	Transcriptional regulator
G4Z16_RS20610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Z16_RS20625	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS20630	COG2610	gluconate transmembrane transporter activity
G4Z16_RS20635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS20640	COG1695	Transcriptional regulator
G4Z16_RS20705	COG0708	Exodeoxyribonuclease III
G4Z16_RS20715	COG0346	lactoylglutathione lyase activity
G4Z16_RS20730	COG2072	flavoprotein involved in K transport
G4Z16_RS20735	COG2267	carboxylic ester hydrolase activity
G4Z16_RS20740	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS20750	COG4946	Tricorn protease homolog
G4Z16_RS20750	COG0793	Belongs to the peptidase S41A family
G4Z16_RS20760	COG0310	cobalt ion transport
G4Z16_RS20770	COG1122	ATPase activity
G4Z16_RS20835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4Z16_RS20840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4Z16_RS20850	COG0084	hydrolase, TatD family'
G4Z16_RS20885	COG0488	(ABC) transporter
G4Z16_RS20910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4Z16_RS20920	COG2197	response regulator
G4Z16_RS20935	COG4106	trans-aconitate 2-methyltransferase activity
G4Z16_RS20960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G4Z16_RS20970	COG0193	aminoacyl-tRNA hydrolase activity
G4Z16_RS20975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4Z16_RS20980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Z16_RS20985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4Z16_RS21000	COG4585	Histidine kinase
G4Z16_RS21035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS21045	COG1136	(ABC) transporter
G4Z16_RS21050	COG0577	efflux transmembrane transporter activity
G4Z16_RS21050	COG1136	(ABC) transporter
G4Z16_RS21085	COG2124	cytochrome p450
G4Z16_RS21095	COG0148	phosphopyruvate hydratase activity
G4Z16_RS21120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Z16_RS21130	COG4209	transmembrane transport
G4Z16_RS21135	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS21145	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS21150	COG0577	efflux transmembrane transporter activity
G4Z16_RS21155	COG1136	(ABC) transporter
G4Z16_RS21200	COG0662	Cupin 2, conserved barrel domain protein
G4Z16_RS21225	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Z16_RS21230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Z16_RS21255	COG0183	Belongs to the thiolase family
G4Z16_RS21260	COG2755	lipolytic protein G-D-S-L family
G4Z16_RS21275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4Z16_RS21285	COG1174	glycine betaine transport
G4Z16_RS21290	COG1174	glycine betaine transport
G4Z16_RS21300	COG2986	histidine ammonia-lyase
G4Z16_RS21315	COG0531	amino acid
G4Z16_RS21325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4Z16_RS21335	COG0583	DNA-binding transcription factor activity
G4Z16_RS21345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G4Z16_RS21360	COG1228	amidohydrolase
G4Z16_RS21365	COG1191	sigma factor activity
G4Z16_RS21400	COG2205	protein histidine kinase activity
G4Z16_RS21405	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS21410	COG3104	oligopeptide transport
G4Z16_RS21425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4Z16_RS21440	COG1316	TRANSCRIPTIONal
G4Z16_RS21445	COG1607	acyl-coa hydrolase
G4Z16_RS21450	COG1316	TRANSCRIPTIONal
G4Z16_RS21465	COG1316	TRANSCRIPTIONal
G4Z16_RS21470	COG1316	TRANSCRIPTIONal
G4Z16_RS21485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Z16_RS21495	COG0778	Nitroreductase
G4Z16_RS21495	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4Z16_RS21500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4Z16_RS21550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Z16_RS21565	COG1482	cell wall glycoprotein biosynthetic process
G4Z16_RS21575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G4Z16_RS21615	COG0714	Associated with various cellular activities
G4Z16_RS21635	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4Z16_RS21640	COG0745	RESPONSE REGULATOR receiver
G4Z16_RS21645	COG5000	phosphorelay sensor kinase activity
G4Z16_RS21645	COG5002	protein histidine kinase activity
G4Z16_RS21650	COG0823	Involved in the tonB-independent uptake of proteins
G4Z16_RS21660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4Z16_RS21665	COG2197	response regulator
G4Z16_RS21670	COG3214	Protein conserved in bacteria
G4Z16_RS21680	COG0653	protein targeting
G4Z16_RS21700	COG2902	Dehydrogenase
G4Z16_RS21720	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS21725	COG1175	transmembrane transport
G4Z16_RS21730	COG1653	transport
G4Z16_RS21740	COG0515	serine threonine protein kinase
G4Z16_RS21745	COG0515	serine threonine protein kinase
G4Z16_RS21750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4Z16_RS21765	COG2884	Cell division ATP-binding protein ftsE
G4Z16_RS21775	COG0793	Belongs to the peptidase S41A family
G4Z16_RS21780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4Z16_RS21805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Z16_RS21815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS21820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS21845	COG2223	nitrite transmembrane transporter activity
G4Z16_RS21860	COG3973	AAA domain
G4Z16_RS21860	COG3973	AAA domain
G4Z16_RS21865	COG1278	Cold shock
G4Z16_RS21875	COG0776	regulation of translation
G4Z16_RS21880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4Z16_RS21885	COG1678	Uncharacterized ACR, COG1678
G4Z16_RS21900	COG1175	transmembrane transport
G4Z16_RS21905	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS21910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G4Z16_RS21960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Z16_RS21985	COG3655	Transcriptional regulator
G4Z16_RS22005	COG3654	unkown
G4Z16_RS22010	COG0583	DNA-binding transcription factor activity
G4Z16_RS22015	COG3415	Transposase
G4Z16_RS22015	COG2801	Transposase and inactivated derivatives
G4Z16_RS22025	COG2855	membrane
G4Z16_RS22050	COG1174	glycine betaine transport
G4Z16_RS22060	COG1174	glycine betaine transport
G4Z16_RS22070	COG3185	4-Hydroxyphenylpyruvate dioxygenase
G4Z16_RS22075	COG0277	FAD linked oxidase domain protein
G4Z16_RS22130	COG1335	isochorismatase
G4Z16_RS22140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G4Z16_RS22150	COG1113	amino acid transport
G4Z16_RS22180	COG1234	tRNA 3'-trailer cleavage
G4Z16_RS22190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4Z16_RS22195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4Z16_RS22205	COG2733	membrane
G4Z16_RS22215	COG4555	ABC transporter
G4Z16_RS22225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4Z16_RS22230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4Z16_RS22255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4Z16_RS22275	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS22285	COG1940	carbohydrate kinase activity
G4Z16_RS22315	COG3397	chitin binding
G4Z16_RS22330	COG1126	abc transporter atp-binding protein
G4Z16_RS22335	COG0765	amino acid transport
G4Z16_RS22340	COG0765	amino acid transport
G4Z16_RS22345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Z16_RS22355	COG0154	amidase activity
G4Z16_RS22375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS22420	COG0588	phosphoglycerate mutase activity
G4Z16_RS22455	COG3979	chitinase
G4Z16_RS22460	COG0739	heme binding
G4Z16_RS22475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G4Z16_RS22480	COG4977	sequence-specific DNA binding
G4Z16_RS22490	COG0589	response to stress
G4Z16_RS22495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Z16_RS22510	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS22525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Z16_RS22530	COG1309	transcriptional regulator
G4Z16_RS22540	COG1946	Acyl-CoA thioesterase
G4Z16_RS22570	COG1554	hydrolase, family 65, central catalytic
G4Z16_RS22590	COG1609	Transcriptional regulator
G4Z16_RS22610	COG1653	transport
G4Z16_RS22615	COG1175	transmembrane transport
G4Z16_RS22620	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS22630	COG0673	inositol 2-dehydrogenase activity
G4Z16_RS22680	COG1869	D-ribose catabolic process
G4Z16_RS22685	COG1879	ABC-type sugar transport system periplasmic component
G4Z16_RS22690	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS22695	COG1129	ABC transporter
G4Z16_RS22700	COG1609	Transcriptional regulator
G4Z16_RS22705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4Z16_RS22730	COG1312	Catalyzes the dehydration of D-mannonate
G4Z16_RS22735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z16_RS22745	COG3718	enzyme involved in inositol metabolism
G4Z16_RS22750	COG3962	Belongs to the TPP enzyme family
G4Z16_RS22760	COG2226	methyltransferase
G4Z16_RS22780	COG2197	response regulator
G4Z16_RS22785	COG4585	Histidine kinase
G4Z16_RS22790	COG1289	transmembrane transporter activity
G4Z16_RS22795	COG3285	dna ligase
G4Z16_RS22795	COG1793	dna ligase
G4Z16_RS22805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4Z16_RS22815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4Z16_RS22835	COG0577	efflux transmembrane transporter activity
G4Z16_RS22835	COG1136	(ABC) transporter
G4Z16_RS22870	COG2197	response regulator
G4Z16_RS22875	COG0672	)-iron permease
G4Z16_RS22880	COG2837	iron assimilation
G4Z16_RS22900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS22905	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Z16_RS22910	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS22925	COG2271	Major facilitator Superfamily
G4Z16_RS22935	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS22940	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Z16_RS22950	COG0076	glutamate decarboxylase activity
G4Z16_RS22955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4Z16_RS22965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4Z16_RS22975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Z16_RS22985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Z16_RS22990	COG3119	arylsulfatase activity
G4Z16_RS23005	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS23010	COG1175	transmembrane transport
G4Z16_RS23020	COG1609	Transcriptional regulator
G4Z16_RS23060	COG1404	Belongs to the peptidase S8 family
G4Z16_RS23070	COG1408	metallophosphoesterase
G4Z16_RS23075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Z16_RS23090	COG2382	esterase
G4Z16_RS23110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4Z16_RS23115	COG0066	3-isopropylmalate dehydratase activity
G4Z16_RS23150	COG0629	single-stranded DNA binding
G4Z16_RS23180	COG0842	Transport permease protein
G4Z16_RS23185	COG1131	(ABC) transporter
G4Z16_RS23225	COG1486	melibiose metabolic process
G4Z16_RS23235	COG0668	transmembrane transport
G4Z16_RS23245	COG3291	Pkd domain containing protein
G4Z16_RS23245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G4Z16_RS23300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4Z16_RS23305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4Z16_RS23310	COG1113	amino acid transport
G4Z16_RS23330	COG4552	Acetyltransferase involved in intracellular survival and related
G4Z16_RS23340	COG3594	Acyltransferase
G4Z16_RS23365	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4Z16_RS23370	COG0740	serine-type endopeptidase activity
G4Z16_RS23375	COG0740	serine-type endopeptidase activity
G4Z16_RS23380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4Z16_RS23395	COG0525	valine-tRNA ligase activity
G4Z16_RS23400	COG0285	dihydrofolate synthase activity
G4Z16_RS23410	COG0105	UTP biosynthetic process
G4Z16_RS23415	COG1077	Cell shape determining protein MreB Mrl
G4Z16_RS23435	COG0772	Belongs to the SEDS family
G4Z16_RS23455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Z16_RS23470	COG1530	ribonuclease E activity
G4Z16_RS23475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Z16_RS23480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4Z16_RS23485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Z16_RS23510	COG3979	chitinase
G4Z16_RS23515	COG2318	DinB family
G4Z16_RS23575	COG0583	DNA-binding transcription factor activity
G4Z16_RS23585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4Z16_RS23595	COG2197	response regulator
G4Z16_RS23610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4Z16_RS23625	COG0501	Belongs to the peptidase M48B family
G4Z16_RS23635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4Z16_RS23675	COG0495	leucyl-tRNA aminoacylation
G4Z16_RS23685	COG1307	EDD domain protein, DegV family
G4Z16_RS23690	COG1555	photosystem II stabilization
G4Z16_RS23715	COG2197	response regulator
G4Z16_RS23720	COG0268	Binds directly to 16S ribosomal RNA
G4Z16_RS23725	COG0481	GTPase activity
G4Z16_RS23740	COG2205	protein histidine kinase activity
G4Z16_RS23740	COG0784	Response regulator, receiver
G4Z16_RS23760	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G4Z16_RS23780	COG1420	regulation of RNA biosynthetic process
G4Z16_RS23785	COG0484	heat shock protein binding
G4Z16_RS23800	COG0537	adenosine 5'-monophosphoramidase activity
G4Z16_RS23805	COG1234	tRNA 3'-trailer cleavage
G4Z16_RS23830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G4Z16_RS23835	COG1414	Transcriptional regulator
G4Z16_RS23845	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS23850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4Z16_RS23850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4Z16_RS23860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4Z16_RS23870	COG2315	Protein conserved in bacteria
G4Z16_RS23880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4Z16_RS23885	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS23890	COG0662	Cupin 2, conserved barrel domain protein
G4Z16_RS23895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Z16_RS23900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Z16_RS23905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Z16_RS23910	COG2226	methyltransferase
G4Z16_RS23910	COG2867	negative regulation of translational initiation
G4Z16_RS23915	COG2226	methyltransferase
G4Z16_RS23915	COG2867	negative regulation of translational initiation
G4Z16_RS23920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4Z16_RS23920	COG0825	malonyl-CoA metabolic process
G4Z16_RS23925	COG0511	ligase activity, forming carbon-carbon bonds
G4Z16_RS23930	COG0439	Biotin carboxylase
G4Z16_RS23935	COG2345	Transcriptional regulator
G4Z16_RS23960	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Z16_RS23970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4Z16_RS23980	COG2329	Antibiotic biosynthesis monooxygenase
G4Z16_RS24020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Z16_RS24050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4Z16_RS24065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4Z16_RS24070	COG1121	(ABC) transporter
G4Z16_RS24080	COG0423	glycine-tRNA ligase activity
G4Z16_RS24100	COG0667	Aldo Keto reductase
G4Z16_RS24110	COG1063	alcohol dehydrogenase
G4Z16_RS24115	COG3360	Dodecin
G4Z16_RS24130	COG1082	Xylose isomerase domain protein TIM barrel
G4Z16_RS24135	COG1063	alcohol dehydrogenase
G4Z16_RS24145	COG1175	transmembrane transport
G4Z16_RS24150	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS24155	COG1940	carbohydrate kinase activity
G4Z16_RS24155	COG1846	Transcriptional regulator
G4Z16_RS24165	COG0574	Belongs to the PEP-utilizing enzyme family
G4Z16_RS24165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Z16_RS24170	COG0477	Major facilitator Superfamily
G4Z16_RS24195	COG4565	transcriptional regulatory protein
G4Z16_RS24200	COG0300	oxidoreductase activity
G4Z16_RS24205	COG0596	Alpha beta hydrolase
G4Z16_RS24210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Z16_RS24215	COG3485	protocatechuate 3,4-dioxygenase
G4Z16_RS24220	COG3485	protocatechuate 3,4-dioxygenase
G4Z16_RS24235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Z16_RS24235	COG2146	nitrite reductase [NAD(P)H] activity
G4Z16_RS24240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Z16_RS24270	COG2949	membrane
G4Z16_RS24275	COG0243	molybdopterin cofactor binding
G4Z16_RS24290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4Z16_RS24300	COG0358	DNA primase activity
G4Z16_RS24305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Z16_RS24320	COG1070	Carbohydrate kinase
G4Z16_RS24370	COG3285	dna ligase
G4Z16_RS24370	COG1793	dna ligase
G4Z16_RS24375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4Z16_RS24380	COG1414	Transcriptional regulator
G4Z16_RS24385	COG3386	PFAM SMP-30 Gluconolaconase
G4Z16_RS24395	COG2130	NADP-dependent
G4Z16_RS24400	COG1764	response to oxidative stress
G4Z16_RS24405	COG4214	carbohydrate transport
G4Z16_RS24430	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS24450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Z16_RS24455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Z16_RS24460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Z16_RS24485	COG0789	Transcriptional regulator
G4Z16_RS24490	COG0667	Aldo Keto reductase
G4Z16_RS24500	COG2197	response regulator
G4Z16_RS24505	COG4585	Histidine kinase
G4Z16_RS24520	COG1309	transcriptional regulator
G4Z16_RS24525	COG0477	Major facilitator Superfamily
G4Z16_RS24535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4Z16_RS24580	COG1358	cellular component organization or biogenesis
G4Z16_RS24590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4Z16_RS24600	COG1357	PFAM Pentapeptide repeats (8 copies)
G4Z16_RS24675	COG3469	chitinase activity
G4Z16_RS24710	COG2197	response regulator
G4Z16_RS24715	COG4585	Histidine kinase
G4Z16_RS24720	COG2311	Membrane
G4Z16_RS24755	COG3845	ABC transporter
G4Z16_RS24780	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4Z16_RS24785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4Z16_RS24790	COG1984	allophanate hydrolase subunit 2
G4Z16_RS24795	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS24830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Z16_RS24850	COG2030	dehydratase
G4Z16_RS24860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4Z16_RS24875	COG0800	Aldolase
G4Z16_RS24880	COG3022	response to hydroperoxide
G4Z16_RS24885	COG2208	phosphoserine phosphatase activity
G4Z16_RS24885	COG2770	Histidine kinase
G4Z16_RS24940	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS24960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Z16_RS24965	COG3321	synthase
G4Z16_RS24965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4Z16_RS24975	COG1609	Transcriptional regulator
G4Z16_RS24995	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS25000	COG2814	Major facilitator Superfamily
G4Z16_RS25005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z16_RS25015	COG1834	amidinotransferase
G4Z16_RS25060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Z16_RS25085	COG1994	Peptidase M50
G4Z16_RS25090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4Z16_RS25095	COG0477	Major facilitator Superfamily
G4Z16_RS25110	COG2814	Major facilitator Superfamily
G4Z16_RS25125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4Z16_RS25125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Z16_RS25135	COG0174	glutamine synthetase
G4Z16_RS25145	COG1476	TRANSCRIPTIONal
G4Z16_RS25160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4Z16_RS25170	COG1609	Transcriptional regulator
G4Z16_RS25180	COG1175	transmembrane transport
G4Z16_RS25190	COG0366	Alpha amylase catalytic
G4Z16_RS25210	COG2197	response regulator
G4Z16_RS25240	COG2318	DinB family
G4Z16_RS25250	COG0321	lipoyl(octanoyl) transferase activity
G4Z16_RS25255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4Z16_RS25310	COG1278	Cold shock
G4Z16_RS25315	COG0513	Belongs to the DEAD box helicase family
G4Z16_RS25380	COG2226	methyltransferase
G4Z16_RS25385	COG1132	(ABC) transporter
G4Z16_RS25425	COG1309	transcriptional regulator
G4Z16_RS25440	COG0477	Major facilitator Superfamily
G4Z16_RS25445	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS25455	COG0183	Belongs to the thiolase family
G4Z16_RS25465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS25470	COG1309	transcriptional regulator
G4Z16_RS25490	COG0456	acetyltransferase
G4Z16_RS25525	COG3979	chitinase
G4Z16_RS25540	COG2027	D-alanyl-D-alanine carboxypeptidase
G4Z16_RS25570	COG4115	mRNA cleavage
G4Z16_RS25575	COG2161	toxin-antitoxin pair type II binding
G4Z16_RS25585	COG2838	Isocitrate dehydrogenase
G4Z16_RS25590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Z16_RS25595	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS25620	COG1653	transport
G4Z16_RS25635	COG0531	amino acid
G4Z16_RS25645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4Z16_RS25670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4Z16_RS25670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Z16_RS25695	COG0477	Major facilitator Superfamily
G4Z16_RS25750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4Z16_RS25785	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS25810	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Z16_RS25815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Z16_RS25820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4Z16_RS25825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G4Z16_RS25830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G4Z16_RS25870	COG2197	response regulator
G4Z16_RS25880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4Z16_RS25900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z16_RS25910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4Z16_RS25915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Z16_RS25925	COG1376	ErfK ybiS ycfS ynhG family protein
G4Z16_RS25935	COG1845	cytochrome c oxidase, subunit III
G4Z16_RS25940	COG2010	Cytochrome c
G4Z16_RS25945	COG0723	plastoquinol--plastocyanin reductase activity
G4Z16_RS25950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4Z16_RS25955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4Z16_RS25960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Z16_RS25985	COG0791	NLP P60 protein
G4Z16_RS25995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Z16_RS26005	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS26025	COG0003	Pfam Anion-transporting ATPase
G4Z16_RS26035	COG1940	carbohydrate kinase activity
G4Z16_RS26060	COG4585	Histidine kinase
G4Z16_RS26065	COG2197	response regulator
G4Z16_RS26070	COG0205	6-phosphofructokinase activity
G4Z16_RS26080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G4Z16_RS26090	COG2193	ferroxidase activity
G4Z16_RS26095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Z16_RS26105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G4Z16_RS26115	COG2815	serine threonine protein kinase
G4Z16_RS26115	COG0515	serine threonine protein kinase
G4Z16_RS26120	COG2022	thiamine diphosphate biosynthetic process
G4Z16_RS26130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z16_RS26130	COG2022	thiamine diphosphate biosynthetic process
G4Z16_RS26135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Z16_RS26145	COG0352	thiamine-phosphate diphosphorylase activity
G4Z16_RS26165	COG1309	transcriptional regulator
G4Z16_RS26175	COG1129	ABC transporter
G4Z16_RS26205	COG0714	Associated with various cellular activities
G4Z16_RS26215	COG0275	rRNA processing
G4Z16_RS26230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4Z16_RS26235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4Z16_RS26240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Z16_RS26245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4Z16_RS26255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4Z16_RS26260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4Z16_RS26270	COG1496	oxidoreductase activity
G4Z16_RS26275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4Z16_RS26280	COG1799	cell septum assembly
G4Z16_RS26295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4Z16_RS26305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4Z16_RS26335	COG1802	Transcriptional regulator
G4Z16_RS26345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4Z16_RS26360	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS26370	COG0477	Major facilitator Superfamily
G4Z16_RS26395	COG0587	DNA-directed DNA polymerase activity
G4Z16_RS26405	COG1432	Conserved Protein
G4Z16_RS26425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4Z16_RS26440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4Z16_RS26445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4Z16_RS26450	COG0131	Imidazoleglycerol-phosphate dehydratase
G4Z16_RS26460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4Z16_RS26465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4Z16_RS26470	COG0251	oxidation-reduction process
G4Z16_RS26475	COG0107	imidazoleglycerol-phosphate synthase activity
G4Z16_RS26545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4Z16_RS26565	COG0134	indole-3-glycerol-phosphate synthase activity
G4Z16_RS26570	COG0133	tryptophan synthase activity
G4Z16_RS26575	COG0159	tryptophan synthase activity
G4Z16_RS26585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4Z16_RS26590	COG2301	Belongs to the HpcH HpaI aldolase family
G4Z16_RS26595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4Z16_RS26600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Z16_RS26635	COG1175	transmembrane transport
G4Z16_RS26640	COG1609	Transcriptional regulator
G4Z16_RS26650	COG0070	glutamate synthase
G4Z16_RS26650	COG0069	glutamate synthase activity
G4Z16_RS26650	COG0067	glutamate synthase
G4Z16_RS26680	COG3467	pyridoxamine 5'-phosphate
G4Z16_RS26690	COG1605	Chorismate mutase
G4Z16_RS26690	COG0287	Prephenate dehydrogenase
G4Z16_RS26760	COG0559	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS26775	COG2050	protein possibly involved in aromatic compounds catabolism
G4Z16_RS26795	COG2226	methyltransferase
G4Z16_RS26800	COG0539	negative regulation of cytoplasmic translation
G4Z16_RS26810	COG0237	dephospho-CoA kinase activity
G4Z16_RS26830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4Z16_RS26855	COG0596	Alpha beta hydrolase
G4Z16_RS26865	COG1254	Belongs to the acylphosphatase family
G4Z16_RS26880	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z16_RS26880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Z16_RS26900	COG2814	Major facilitator Superfamily
G4Z16_RS26905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4Z16_RS26910	COG0584	glycerophosphoryl diester phosphodiesterase
G4Z16_RS26915	COG0556	nucleotide-excision repair
G4Z16_RS26940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4Z16_RS26955	COG0322	excinuclease ABC activity
G4Z16_RS26960	COG1660	Displays ATPase and GTPase activities
G4Z16_RS26965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4Z16_RS26970	COG1481	regulation of sporulation
G4Z16_RS26975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Z16_RS26980	COG0126	phosphoglycerate kinase activity
G4Z16_RS26985	COG0149	triose-phosphate isomerase activity
G4Z16_RS26990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4Z16_RS27000	COG0166	Belongs to the GPI family
G4Z16_RS27005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4Z16_RS27010	COG0363	glucosamine-6-phosphate deaminase activity
G4Z16_RS27025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Z16_RS27035	COG0109	protoheme IX farnesyltransferase activity
G4Z16_RS27060	COG1131	(ABC) transporter
G4Z16_RS27075	COG0719	Fe-S assembly protein
G4Z16_RS27085	COG0396	ATPase activity
G4Z16_RS27090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Z16_RS27095	COG0822	iron-sulfur transferase activity
G4Z16_RS27110	COG2076	Multidrug Resistance protein
G4Z16_RS27115	COG3226	Transcriptional regulator
G4Z16_RS27120	COG2171	N-acyltransferase activity
G4Z16_RS27190	COG2261	transglycosylase associated protein
G4Z16_RS27195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Z16_RS27200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Z16_RS27225	COG1414	Transcriptional regulator
G4Z16_RS27240	COG5285	phytanoyl-CoA dioxygenase
G4Z16_RS27245	COG1917	Cupin 2, conserved barrel domain protein
G4Z16_RS27250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Z16_RS27270	COG2186	Transcriptional regulator
G4Z16_RS27280	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS27285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4Z16_RS27285	COG0825	malonyl-CoA metabolic process
G4Z16_RS27305	COG1797	cobyrinic acid a,c-diamide synthase activity
G4Z16_RS27310	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G4Z16_RS27325	COG1492	cobalamin metabolic process
G4Z16_RS27330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G4Z16_RS27350	COG0235	Class ii aldolase
G4Z16_RS27370	COG0488	(ABC) transporter
G4Z16_RS27425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Z16_RS27445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS27450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4Z16_RS27470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4Z16_RS27475	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS27480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4Z16_RS27485	COG2186	Transcriptional regulator
G4Z16_RS27505	COG0560	Phosphoserine phosphatase
G4Z16_RS27505	COG3830	Belongs to the UPF0237 family
G4Z16_RS27510	COG0842	Transport permease protein
G4Z16_RS27510	COG1131	(ABC) transporter
G4Z16_RS27510	COG1716	ATPase activity
G4Z16_RS27525	COG2197	response regulator
G4Z16_RS27535	COG1119	ATPase activity
G4Z16_RS27560	COG1881	PFAM PEBP family protein
G4Z16_RS27575	COG2094	Belongs to the DNA glycosylase MPG family
G4Z16_RS27615	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G4Z16_RS27630	COG0647	UMP catabolic process
G4Z16_RS27635	COG1132	(ABC) transporter
G4Z16_RS27635	COG2375	cellular response to nickel ion
G4Z16_RS27645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Z16_RS27650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Z16_RS27655	COG1120	ATPase activity
G4Z16_RS27670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4Z16_RS27675	COG0497	DNA recombination
G4Z16_RS27685	COG0297	glycogen (starch) synthase activity
G4Z16_RS27705	COG3387	PFAM Glycoside hydrolase 15-related
G4Z16_RS27710	COG0504	CTP synthase activity
G4Z16_RS27715	COG0494	nUDIX hydrolase
G4Z16_RS27730	COG0686	Belongs to the AlaDH PNT family
G4Z16_RS27750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4Z16_RS27755	COG1187	pseudouridine synthase activity
G4Z16_RS27770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4Z16_RS27780	COG1160	GTP binding
G4Z16_RS27795	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS27820	COG0671	phosphoesterase, PA-phosphatase related
G4Z16_RS27825	COG0477	Major facilitator Superfamily
G4Z16_RS27830	COG1799	cell septum assembly
G4Z16_RS27845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Z16_RS27850	COG0587	DNA-directed DNA polymerase activity
G4Z16_RS27855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4Z16_RS27895	COG3384	dioxygenase
G4Z16_RS27915	COG1725	Transcriptional regulator
G4Z16_RS27940	COG2188	Transcriptional regulator
G4Z16_RS27945	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G4Z16_RS27950	COG0243	molybdopterin cofactor binding
G4Z16_RS28010	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS28055	COG3265	gluconokinase activity
G4Z16_RS28065	COG2149	membrane
G4Z16_RS28070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4Z16_RS28085	COG2188	Transcriptional regulator
G4Z16_RS28100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4Z16_RS28110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Z16_RS28115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4Z16_RS28150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Z16_RS28165	COG2329	Antibiotic biosynthesis monooxygenase
G4Z16_RS28175	COG1486	melibiose metabolic process
G4Z16_RS28185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4Z16_RS28185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4Z16_RS28190	COG1653	transport
G4Z16_RS28195	COG1175	transmembrane transport
G4Z16_RS28205	COG2814	Major facilitator Superfamily
G4Z16_RS28215	COG1609	Transcriptional regulator
G4Z16_RS28300	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4Z16_RS28330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4Z16_RS28340	COG0375	protein maturation
G4Z16_RS28345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G4Z16_RS28350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G4Z16_RS28365	COG0309	Hydrogenase expression formation protein (HypE)
G4Z16_RS28370	COG0726	polysaccharide deacetylase
G4Z16_RS28380	COG4221	oxidoreductase activity
G4Z16_RS28410	COG2188	Transcriptional regulator
G4Z16_RS28440	COG2508	Transcriptional regulator
G4Z16_RS28455	COG1309	transcriptional regulator
G4Z16_RS28460	COG1834	amidinotransferase
G4Z16_RS28490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4Z16_RS28495	COG0129	dihydroxy-acid dehydratase activity
G4Z16_RS28510	COG2814	Major facilitator Superfamily
G4Z16_RS28545	COG1802	Transcriptional regulator
G4Z16_RS28570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4Z16_RS28575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Z16_RS28580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4Z16_RS28585	COG0254	rRNA binding
G4Z16_RS28595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Z16_RS28610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z16_RS28640	COG0667	Aldo Keto reductase
G4Z16_RS28645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS28650	COG0598	Magnesium transport protein CorA
G4Z16_RS28670	COG0215	cysteine-tRNA ligase activity
G4Z16_RS28680	COG0366	Alpha amylase catalytic
G4Z16_RS28690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4Z16_RS28695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4Z16_RS28700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4Z16_RS28705	COG1414	Transcriptional regulator
G4Z16_RS28710	COG1410	methionine synthase
G4Z16_RS28710	COG0646	methionine synthase
G4Z16_RS28725	COG2197	response regulator
G4Z16_RS28735	COG0517	IMP dehydrogenase activity
G4Z16_RS28735	COG1994	Peptidase M50
G4Z16_RS28755	COG1222	aaa ATPase
G4Z16_RS28760	COG4122	O-methyltransferase activity
G4Z16_RS28770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G4Z16_RS28775	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G4Z16_RS28780	COG1609	Transcriptional regulator
G4Z16_RS28790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G4Z16_RS28795	COG0545	Peptidyl-prolyl cis-trans isomerase
G4Z16_RS28820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4Z16_RS28825	COG0805	protein transport
G4Z16_RS28850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Z16_RS28855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4Z16_RS28860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G4Z16_RS28865	COG0531	amino acid
G4Z16_RS28880	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS28915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4Z16_RS28925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Z16_RS28930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4Z16_RS28935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4Z16_RS28940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Z16_RS28945	COG5002	protein histidine kinase activity
G4Z16_RS28950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4Z16_RS28955	COG0072	phenylalanine-tRNA ligase activity
G4Z16_RS28955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4Z16_RS28970	COG1649	PFAM Uncharacterised BCR, COG1649
G4Z16_RS28980	COG0697	spore germination
G4Z16_RS28985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Z16_RS29010	COG4941	Belongs to the sigma-70 factor family
G4Z16_RS29035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4Z16_RS29040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4Z16_RS29045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4Z16_RS29050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4Z16_RS29055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Z16_RS29060	COG1438	arginine binding
G4Z16_RS29075	COG2188	Transcriptional regulator
G4Z16_RS29085	COG0137	argininosuccinate synthase activity
G4Z16_RS29090	COG0165	Argininosuccinate lyase
G4Z16_RS29110	COG0204	Acyl-transferase
G4Z16_RS29110	COG0318	PFAM AMP-dependent synthetase and ligase
G4Z16_RS29115	COG0584	glycerophosphoryl diester phosphodiesterase
G4Z16_RS29150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G4Z16_RS29155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Z16_RS29155	COG1648	precorrin-2 dehydrogenase activity
G4Z16_RS29160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Z16_RS29210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4Z16_RS29215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Z16_RS29275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4Z16_RS29290	COG0531	amino acid
G4Z16_RS29310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4Z16_RS29315	COG1560	Kdo2-lipid A biosynthetic process
G4Z16_RS29320	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS29330	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G4Z16_RS29335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4Z16_RS29340	COG0217	transcriptional regulatory protein
G4Z16_RS29345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G4Z16_RS29350	COG0632	four-way junction helicase activity
G4Z16_RS29355	COG2255	four-way junction helicase activity
G4Z16_RS29365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4Z16_RS29370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4Z16_RS29375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4Z16_RS29380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Z16_RS29385	COG1196	nuclear chromosome segregation
G4Z16_RS29390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4Z16_RS29400	COG0124	histidyl-tRNA synthetase
G4Z16_RS29420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4Z16_RS29435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Z16_RS29440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4Z16_RS29445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4Z16_RS29450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4Z16_RS29455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4Z16_RS29460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4Z16_RS29465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4Z16_RS29475	COG0006	proline dipeptidase activity
G4Z16_RS29480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4Z16_RS29485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Z16_RS29495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G4Z16_RS29500	COG0540	Belongs to the ATCase OTCase family
G4Z16_RS29505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Z16_RS29515	COG0505	Belongs to the CarA family
G4Z16_RS29520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4Z16_RS29525	COG0167	dihydroorotate dehydrogenase activity
G4Z16_RS29530	COG0284	orotidine-5'-phosphate decarboxylase activity
G4Z16_RS29545	COG1758	RNA polymerase activity
G4Z16_RS29555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4Z16_RS29570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4Z16_RS29590	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS29595	COG1024	Enoyl-CoA hydratase
G4Z16_RS29605	COG0277	FAD linked oxidase domain protein
G4Z16_RS29605	COG0247	lactate metabolic process
G4Z16_RS29610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G4Z16_RS29625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4Z16_RS29630	COG2390	Transcriptional regulator
G4Z16_RS29640	COG0475	glutathione-regulated potassium exporter activity
G4Z16_RS29705	COG0277	FAD linked oxidase domain protein
G4Z16_RS29710	COG0277	FAD linked oxidase domain protein
G4Z16_RS29715	COG0247	lactate metabolic process
G4Z16_RS29720	COG1620	l-lactate permease
G4Z16_RS29740	COG0531	amino acid
G4Z16_RS29745	COG1522	sequence-specific DNA binding
G4Z16_RS29750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Z16_RS29760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Z16_RS29775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS29790	COG2223	nitrite transmembrane transporter activity
G4Z16_RS29805	COG3201	nicotinamide mononucleotide transporter
G4Z16_RS29810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4Z16_RS29810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4Z16_RS29815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4Z16_RS29820	COG0140	phosphoribosyl-ATP diphosphatase activity
G4Z16_RS29825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4Z16_RS29850	COG0572	uridine kinase
G4Z16_RS29885	COG0701	Predicted permease
G4Z16_RS29900	COG0438	transferase activity, transferring glycosyl groups
G4Z16_RS29935	COG0477	Major facilitator Superfamily
G4Z16_RS29940	COG3876	Protein conserved in bacteria
G4Z16_RS29965	COG1556	Lactate utilization protein
G4Z16_RS29970	COG1139	Iron-sulfur cluster binding protein
G4Z16_RS29975	COG0247	lactate metabolic process
G4Z16_RS29980	COG1070	Carbohydrate kinase
G4Z16_RS29985	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS29985	COG3347	Dehydrogenase
G4Z16_RS29995	COG3250	beta-galactosidase activity
G4Z16_RS30000	COG1129	ABC transporter
G4Z16_RS30010	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Z16_RS30015	COG1879	ABC-type sugar transport system periplasmic component
G4Z16_RS30030	COG1609	Transcriptional regulator
G4Z16_RS30035	COG1609	Transcriptional regulator
G4Z16_RS30045	COG0432	Pfam Uncharacterised protein family UPF0047
G4Z16_RS30050	COG1414	Transcriptional regulator
G4Z16_RS30055	COG2301	Belongs to the HpcH HpaI aldolase family
G4Z16_RS30075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Z16_RS30080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4Z16_RS30100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Z16_RS30105	COG2706	6-phosphogluconolactonase activity
G4Z16_RS30120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4Z16_RS30130	COG1309	transcriptional regulator
G4Z16_RS30155	COG0671	phosphoesterase, PA-phosphatase related
G4Z16_RS30180	COG0584	glycerophosphoryl diester phosphodiesterase
G4Z16_RS30220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4Z16_RS30235	COG0515	serine threonine protein kinase
G4Z16_RS30235	COG2815	serine threonine protein kinase
G4Z16_RS30245	COG1609	Transcriptional regulator
G4Z16_RS30265	COG1660	Displays ATPase and GTPase activities
G4Z16_RS30275	COG0445	tRNA wobble uridine modification
G4Z16_RS30290	COG4585	Histidine kinase
G4Z16_RS30295	COG2197	response regulator
G4Z16_RS30310	COG2223	nitrite transmembrane transporter activity
G4Z16_RS30335	COG1136	(ABC) transporter
G4Z16_RS30340	COG0577	efflux transmembrane transporter activity
G4Z16_RS30365	COG1349	DNA-binding transcription factor activity
G4Z16_RS30385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Z16_RS30390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Z16_RS30395	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G4Z16_RS30405	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS30430	COG1215	transferase activity, transferring glycosyl groups
G4Z16_RS30435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4Z16_RS30445	COG1051	belongs to the nudix hydrolase family
G4Z16_RS30450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Z16_RS30470	COG1461	Dihydroxyacetone kinase
G4Z16_RS30475	COG2376	Dihydroxyacetone kinase
G4Z16_RS30495	COG1285	pathogenesis
G4Z16_RS30505	COG0531	amino acid
G4Z16_RS30535	COG0510	thiamine kinase activity
G4Z16_RS30600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4Z16_RS30605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4Z16_RS30625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4Z16_RS30635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4Z16_RS30665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Z16_RS30705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4Z16_RS30715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z16_RS30715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z16_RS30745	COG1695	Transcriptional regulator
G4Z16_RS30775	COG0697	spore germination
G4Z16_RS30780	COG0583	DNA-binding transcription factor activity
G4Z16_RS30790	COG0823	Involved in the tonB-independent uptake of proteins
G4Z16_RS30790	COG1506	peptidase
G4Z16_RS30790	COG4946	Tricorn protease homolog
G4Z16_RS30815	COG0747	negative chemotaxis
G4Z16_RS30820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G4Z16_RS30840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G4Z16_RS30845	COG3537	Alpha-1,2-mannosidase
G4Z16_RS30850	COG0129	dihydroxy-acid dehydratase activity
G4Z16_RS30860	COG1316	TRANSCRIPTIONal
G4Z16_RS30880	COG1968	undecaprenyl-diphosphatase activity
G4Z16_RS30895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Z16_RS30920	COG0110	maltose O-acetyltransferase activity
G4Z16_RS30945	COG1832	CoA-binding protein
G4Z16_RS30950	COG1739	Uncharacterized protein family UPF0029
G4Z16_RS30960	COG0367	asparagine synthase
G4Z16_RS30965	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS30970	COG0420	3'-5' exonuclease activity
G4Z16_RS30975	COG0419	ATPase involved in DNA repair
G4Z16_RS30980	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS31015	COG0346	lactoylglutathione lyase activity
G4Z16_RS31020	COG0435	Glutathione S-transferase
G4Z16_RS31025	COG0596	Alpha beta hydrolase
G4Z16_RS31030	COG1595	DNA-templated transcription, initiation
G4Z16_RS31035	COG1028	Short-chain dehydrogenase reductase Sdr
G4Z16_RS31040	COG2188	Transcriptional regulator
G4Z16_RS31045	COG1940	carbohydrate kinase activity
G4Z16_RS31060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Z16_RS31100	COG2226	methyltransferase
G4Z16_RS31105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4Z16_RS31110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4Z16_RS31115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4Z16_RS31130	COG0740	serine-type endopeptidase activity
G4Z16_RS31140	COG2234	aminopeptidase activity
G4Z16_RS31140	COG4935	Belongs to the peptidase S8 family
G4Z16_RS31150	COG1309	transcriptional regulator
G4Z16_RS31155	COG0596	Alpha beta hydrolase
G4Z16_RS31175	COG3442	glutamine amidotransferase
G4Z16_RS31190	COG1960	acyl-CoA dehydrogenase activity
G4Z16_RS31205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4Z16_RS31230	COG1793	dna ligase
G4Z16_RS31240	COG0142	geranyltranstransferase activity
G4Z16_RS31245	COG0783	Belongs to the Dps family
G4Z16_RS31255	COG1609	Transcriptional regulator
G4Z16_RS31265	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G4Z16_RS31270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4Z16_RS31285	COG1012	belongs to the aldehyde dehydrogenase family
G4Z16_RS31290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Z16_RS31325	COG0596	Alpha beta hydrolase
G4Z16_RS31330	COG0831	urea catabolic process
G4Z16_RS31335	COG0832	Belongs to the urease beta subunit family
G4Z16_RS31340	COG0804	urea catabolic process
G4Z16_RS31350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G4Z16_RS31355	COG0829	nickel cation binding
G4Z16_RS31360	COG3250	beta-galactosidase activity
G4Z16_RS31365	COG2814	Major facilitator Superfamily
G4Z16_RS31370	COG1609	Transcriptional regulator
G4Z16_RS31380	COG3485	protocatechuate 3,4-dioxygenase
G4Z16_RS31385	COG1454	alcohol dehydrogenase
G4Z16_RS31395	COG1414	Transcriptional regulator
G4Z16_RS31415	COG1228	amidohydrolase
G4Z16_RS31420	COG0477	Major facilitator Superfamily
G4Z16_RS31425	COG1396	sequence-specific DNA binding
G4Z16_RS31435	COG0579	oxidoreductase
G4Z16_RS31465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Z16_RS31470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G4Z16_RS31500	COG2197	response regulator
G4Z16_RS31505	COG3851	Histidine kinase
G4Z16_RS31515	COG0586	Pfam SNARE associated Golgi protein
G4Z16_RS31525	COG3250	beta-galactosidase activity
G4Z16_RS31530	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS31535	COG1175	transmembrane transport
G4Z16_RS31545	COG0477	Major facilitator Superfamily
G4Z16_RS31550	COG2723	6-phospho-beta-galactosidase activity
G4Z16_RS31555	COG1940	carbohydrate kinase activity
G4Z16_RS31575	COG1609	Transcriptional regulator
G4Z16_RS31595	COG0395	ABC-type sugar transport system, permease component
G4Z16_RS31650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G4Z16_RS31665	COG0477	Major facilitator Superfamily
G4Z16_RS31675	COG2072	flavoprotein involved in K transport
G4Z16_RS31680	COG0251	oxidation-reduction process
G4Z16_RS31700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G4Z16_RS31700	COG2508	Transcriptional regulator
G4Z16_RS31705	COG2271	Major facilitator Superfamily
G4Z16_RS31720	COG5006	permease, DMT superfamily
G4Z16_RS31730	COG1131	(ABC) transporter
G4Z16_RS31745	COG0583	DNA-binding transcription factor activity
G4Z16_RS31755	COG0519	Catalyzes the synthesis of GMP from XMP
G4Z16_RS31755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Z16_RS31760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4Z16_RS31775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Z16_RS31780	COG0640	Transcriptional regulator
G4Z16_RS31785	COG0604	alcohol dehydrogenase
G4Z16_RS31825	COG0494	nUDIX hydrolase
G4Z16_RS31835	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS31840	COG4948	Mandelate Racemase Muconate Lactonizing
G4Z16_RS31850	COG0640	Transcriptional regulator
G4Z16_RS31895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Z16_RS31910	COG1309	transcriptional regulator
G4Z16_RS32025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Z16_RS32060	COG2080	2 iron, 2 sulfur cluster binding
G4Z16_RS32065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4Z16_RS32070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4Z16_RS32080	COG0789	Transcriptional regulator
G4Z16_RS32115	COG3507	Belongs to the glycosyl hydrolase 43 family