locus-tag	class	description
SBI_RS00065	COG2362	D-Aminopeptidase
SBI_RS00150	COG1335	isochorismatase
SBI_RS00165	COG1733	regulation of RNA biosynthetic process
SBI_RS00215	COG2814	Major facilitator Superfamily
SBI_RS00225	COG1396	sequence-specific DNA binding
SBI_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS00295	COG1073	alpha beta
SBI_RS00315	COG1595	DNA-templated transcription, initiation
SBI_RS00320	COG1309	transcriptional regulator
SBI_RS00330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SBI_RS00330	COG0574	Belongs to the PEP-utilizing enzyme family
SBI_RS00375	COG0583	DNA-binding transcription factor activity
SBI_RS00395	COG0740	serine-type endopeptidase activity
SBI_RS00400	COG0740	serine-type endopeptidase activity
SBI_RS00405	COG0640	Transcriptional regulator
SBI_RS00410	COG4221	oxidoreductase activity
SBI_RS00430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SBI_RS00440	COG0436	Aminotransferase
SBI_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS00460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SBI_RS00465	COG0477	Major facilitator Superfamily
SBI_RS00470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SBI_RS00475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS00480	COG0583	DNA-binding transcription factor activity
SBI_RS00495	COG0587	DNA-directed DNA polymerase activity
SBI_RS00510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS00535	COG0659	secondary active sulfate transmembrane transporter activity
SBI_RS00555	COG1733	regulation of RNA biosynthetic process
SBI_RS00565	COG4335	DNA alkylation repair
SBI_RS00590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS00600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SBI_RS00655	COG0657	acetylesterase activity
SBI_RS00675	COG2124	cytochrome p450
SBI_RS00680	COG2124	cytochrome p450
SBI_RS00725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SBI_RS00725	COG3291	Pkd domain containing protein
SBI_RS00765	COG2837	iron assimilation
SBI_RS00785	COG1960	acyl-CoA dehydrogenase activity
SBI_RS00800	COG0488	(ABC) transporter
SBI_RS00835	COG2814	Major facilitator Superfamily
SBI_RS00840	COG0506	proline dehydrogenase activity
SBI_RS00860	COG1396	sequence-specific DNA binding
SBI_RS00880	COG0640	Transcriptional regulator
SBI_RS00890	COG0442	prolyl-tRNA aminoacylation
SBI_RS00925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SBI_RS00930	COG0667	Aldo Keto reductase
SBI_RS00935	COG1733	regulation of RNA biosynthetic process
SBI_RS00945	COG0142	geranyltranstransferase activity
SBI_RS00975	COG2226	methyltransferase
SBI_RS00995	COG1657	PFAM Prenyltransferase squalene oxidase
SBI_RS01000	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SBI_RS01075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SBI_RS01090	COG1397	ADP-ribosylglycohydrolase
SBI_RS01095	COG2188	Transcriptional regulator
SBI_RS01100	COG2031	fatty acid transporter
SBI_RS01110	COG0640	Transcriptional regulator
SBI_RS01120	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SBI_RS01125	COG1733	regulation of RNA biosynthetic process
SBI_RS01155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS01170	COG0583	DNA-binding transcription factor activity
SBI_RS01185	COG0477	Major facilitator Superfamily
SBI_RS01190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SBI_RS01210	COG0583	DNA-binding transcription factor activity
SBI_RS01220	COG0640	Transcriptional regulator
SBI_RS01235	COG1595	DNA-templated transcription, initiation
SBI_RS01240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SBI_RS01240	COG1017	nitric oxide dioxygenase activity
SBI_RS01245	COG1959	2 iron, 2 sulfur cluster binding
SBI_RS01255	COG1175	transmembrane transport
SBI_RS01260	COG0395	ABC-type sugar transport system, permease component
SBI_RS01275	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS01280	COG1846	Transcriptional regulator
SBI_RS01280	COG1940	carbohydrate kinase activity
SBI_RS01285	COG0235	Class ii aldolase
SBI_RS01305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SBI_RS01325	COG0531	amino acid
SBI_RS01350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SBI_RS01355	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SBI_RS01360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SBI_RS01370	COG0531	amino acid
SBI_RS01385	COG0330	HflC and HflK could
SBI_RS01410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS01425	COG2132	Multicopper oxidase
SBI_RS01450	COG0300	oxidoreductase activity
SBI_RS01450	COG3321	synthase
SBI_RS01450	COG4221	oxidoreductase activity
SBI_RS01450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS01485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SBI_RS01490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS01490	COG2070	2-Nitropropane dioxygenase
SBI_RS01500	COG1733	regulation of RNA biosynthetic process
SBI_RS01515	COG1764	response to oxidative stress
SBI_RS01530	COG1053	succinate dehydrogenase
SBI_RS01550	COG2070	2-Nitropropane dioxygenase
SBI_RS01555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS01560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SBI_RS01575	COG1595	DNA-templated transcription, initiation
SBI_RS01590	COG0477	Major facilitator Superfamily
SBI_RS01620	COG1595	DNA-templated transcription, initiation
SBI_RS01630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SBI_RS01640	COG0166	Belongs to the GPI family
SBI_RS01645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SBI_RS01650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SBI_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS01660	COG1063	alcohol dehydrogenase
SBI_RS01700	COG2146	nitrite reductase [NAD(P)H] activity
SBI_RS01705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SBI_RS01715	COG1414	Transcriptional regulator
SBI_RS01735	COG0114	fumarate hydratase activity
SBI_RS01755	COG3485	protocatechuate 3,4-dioxygenase
SBI_RS01765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SBI_RS01770	COG2124	cytochrome p450
SBI_RS01780	COG1595	DNA-templated transcription, initiation
SBI_RS01815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS01820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SBI_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS01840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SBI_RS01850	COG0477	Major facilitator Superfamily
SBI_RS01890	COG1131	(ABC) transporter
SBI_RS01895	COG0745	RESPONSE REGULATOR receiver
SBI_RS01900	COG2205	protein histidine kinase activity
SBI_RS01905	COG0488	(ABC) transporter
SBI_RS01910	COG0488	(ABC) transporter
SBI_RS01920	COG2197	response regulator
SBI_RS01925	COG4585	Histidine kinase
SBI_RS01935	COG0667	Aldo Keto reductase
SBI_RS01940	COG1309	transcriptional regulator
SBI_RS01950	COG0395	ABC-type sugar transport system, permease component
SBI_RS01960	COG1653	transport
SBI_RS01975	COG0477	Major facilitator Superfamily
SBI_RS02005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SBI_RS02010	COG0667	Aldo Keto reductase
SBI_RS02020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SBI_RS02025	COG1914	H( )-stimulated, divalent metal cation uptake system
SBI_RS02030	COG2186	Transcriptional regulator
SBI_RS02040	COG0277	FAD linked oxidase domain protein
SBI_RS02045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SBI_RS02055	COG0477	Major facilitator Superfamily
SBI_RS02060	COG0583	DNA-binding transcription factor activity
SBI_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS02085	COG4221	oxidoreductase activity
SBI_RS02100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SBI_RS02125	COG0800	Aldolase
SBI_RS02130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS02135	COG0129	dihydroxy-acid dehydratase activity
SBI_RS02160	COG1309	transcriptional regulator
SBI_RS02180	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS02210	COG4608	Belongs to the ABC transporter superfamily
SBI_RS02220	COG1802	Transcriptional regulator
SBI_RS02225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS02230	COG0601	transmembrane transport
SBI_RS02235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SBI_RS02245	COG0747	negative chemotaxis
SBI_RS02255	COG0477	Major facilitator Superfamily
SBI_RS02275	COG1132	(ABC) transporter
SBI_RS02435	COG0829	nickel cation binding
SBI_RS02445	COG1309	transcriptional regulator
SBI_RS02450	COG1309	transcriptional regulator
SBI_RS02510	COG1100	Small GTP-binding protein
SBI_RS02520	COG0542	response to heat
SBI_RS02545	COG4245	von Willebrand factor, type A
SBI_RS02600	COG1609	Transcriptional regulator
SBI_RS02610	COG4733	cellulase activity
SBI_RS02655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SBI_RS02665	COG0009	L-threonylcarbamoyladenylate synthase
SBI_RS02750	COG1674	ftsk spoiiie
SBI_RS02785	COG1501	Belongs to the glycosyl hydrolase 31 family
SBI_RS02790	COG2723	6-phospho-beta-galactosidase activity
SBI_RS02795	COG0395	ABC-type sugar transport system, permease component
SBI_RS02800	COG1175	transmembrane transport
SBI_RS02805	COG2182	Extracellular solute-binding protein
SBI_RS02825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SBI_RS02835	COG1522	sequence-specific DNA binding
SBI_RS02840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SBI_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS02860	COG4608	Belongs to the ABC transporter superfamily
SBI_RS02870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS02880	COG0747	negative chemotaxis
SBI_RS02900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS02900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS02900	COG1703	isobutyryl-CoA mutase activity
SBI_RS02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SBI_RS02915	COG0477	Major facilitator Superfamily
SBI_RS02930	COG4585	Histidine kinase
SBI_RS02935	COG2409	Drug exporters of the RND superfamily
SBI_RS02945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS02960	COG1834	amidinotransferase
SBI_RS02975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS02985	COG2045	Belongs to the ComB family
SBI_RS02990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SBI_RS03035	COG0473	3-isopropylmalate dehydrogenase activity
SBI_RS03040	COG0583	DNA-binding transcription factor activity
SBI_RS03060	COG3831	ATPase activity
SBI_RS03095	COG0604	alcohol dehydrogenase
SBI_RS03095	COG3321	synthase
SBI_RS03105	COG0604	alcohol dehydrogenase
SBI_RS03105	COG3321	synthase
SBI_RS03190	COG2070	2-Nitropropane dioxygenase
SBI_RS03190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS03195	COG0475	glutathione-regulated potassium exporter activity
SBI_RS03200	COG3321	synthase
SBI_RS03200	COG0300	oxidoreductase activity
SBI_RS03200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS03200	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS03200	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS03215	COG3321	synthase
SBI_RS03215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SBI_RS03215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS03240	COG1175	transmembrane transport
SBI_RS03245	COG0395	ABC-type sugar transport system, permease component
SBI_RS03250	COG0366	Alpha amylase catalytic
SBI_RS03270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS03275	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS03280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS03285	COG4166	transmembrane transport
SBI_RS03290	COG0601	transmembrane transport
SBI_RS03295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS03300	COG0444	Belongs to the ABC transporter superfamily
SBI_RS03305	COG4608	Belongs to the ABC transporter superfamily
SBI_RS03320	COG0395	ABC-type sugar transport system, permease component
SBI_RS03325	COG1175	transmembrane transport
SBI_RS03335	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS03340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS03345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SBI_RS03345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SBI_RS03360	COG0583	DNA-binding transcription factor activity
SBI_RS03365	COG2124	cytochrome p450
SBI_RS03370	COG0604	alcohol dehydrogenase
SBI_RS03370	COG3321	synthase
SBI_RS03405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SBI_RS03415	COG0154	amidase activity
SBI_RS03445	COG3290	protein histidine kinase activity
SBI_RS03450	COG4565	transcriptional regulatory protein
SBI_RS03480	COG2124	cytochrome p450
SBI_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS03505	COG3321	synthase
SBI_RS03505	COG0604	alcohol dehydrogenase
SBI_RS03525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SBI_RS03540	COG3622	Belongs to the hyi family
SBI_RS03545	COG2084	Dehydrogenase
SBI_RS03550	COG3960	tartronate-semialdehyde synthase activity
SBI_RS03560	COG0179	Fumarylacetoacetate (FAA) hydrolase
SBI_RS03570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SBI_RS03590	COG2814	Major facilitator Superfamily
SBI_RS03595	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS03615	COG2301	Belongs to the HpcH HpaI aldolase family
SBI_RS03620	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SBI_RS03635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SBI_RS03640	COG0583	DNA-binding transcription factor activity
SBI_RS03655	COG3250	beta-galactosidase activity
SBI_RS03660	COG0640	Transcriptional regulator
SBI_RS03665	COG1802	Transcriptional regulator
SBI_RS03680	COG0667	Aldo Keto reductase
SBI_RS03690	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS03730	COG1132	(ABC) transporter
SBI_RS03735	COG2375	cellular response to nickel ion
SBI_RS03735	COG1132	(ABC) transporter
SBI_RS03740	COG0657	acetylesterase activity
SBI_RS03765	COG2072	flavoprotein involved in K transport
SBI_RS03790	COG1309	transcriptional regulator
SBI_RS03795	COG1609	Transcriptional regulator
SBI_RS03800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS03810	COG3962	Belongs to the TPP enzyme family
SBI_RS03825	COG2814	Major facilitator Superfamily
SBI_RS03830	COG0673	inositol 2-dehydrogenase activity
SBI_RS03835	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS03855	COG1609	Transcriptional regulator
SBI_RS03860	COG2755	lipolytic protein G-D-S-L family
SBI_RS03880	COG3940	Belongs to the glycosyl hydrolase 43 family
SBI_RS03895	COG1653	transport
SBI_RS03900	COG1175	transmembrane transport
SBI_RS03905	COG0395	ABC-type sugar transport system, permease component
SBI_RS03925	COG0583	DNA-binding transcription factor activity
SBI_RS03935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS03945	COG2409	Drug exporters of the RND superfamily
SBI_RS03975	COG0395	ABC-type sugar transport system, permease component
SBI_RS03985	COG1653	transport
SBI_RS03995	COG1609	Transcriptional regulator
SBI_RS04010	COG2197	response regulator
SBI_RS04015	COG4585	Histidine kinase
SBI_RS04025	COG1131	(ABC) transporter
SBI_RS04035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SBI_RS04040	COG0745	RESPONSE REGULATOR receiver
SBI_RS04045	COG2205	protein histidine kinase activity
SBI_RS04050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS04060	COG2706	6-phosphogluconolactonase activity
SBI_RS04080	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SBI_RS04090	COG2226	methyltransferase
SBI_RS04120	COG0596	Alpha beta hydrolase
SBI_RS04155	COG3903	Transcriptional regulator
SBI_RS04155	COG3629	intracellular signal transduction
SBI_RS04160	COG3387	PFAM Glycoside hydrolase 15-related
SBI_RS04165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SBI_RS04170	COG1960	acyl-CoA dehydrogenase activity
SBI_RS04175	COG1522	sequence-specific DNA binding
SBI_RS04180	COG0328	RNA-DNA hybrid ribonuclease activity
SBI_RS04190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SBI_RS04205	COG0166	Belongs to the GPI family
SBI_RS04210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SBI_RS04215	COG0456	acetyltransferase
SBI_RS04220	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS04240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SBI_RS04270	COG3344	reverse transcriptase
SBI_RS04285	COG0477	Major facilitator Superfamily
SBI_RS04295	COG0515	serine threonine protein kinase
SBI_RS04295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS04310	COG0726	polysaccharide deacetylase
SBI_RS04325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SBI_RS04350	COG0436	Aminotransferase
SBI_RS04360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SBI_RS04365	COG0477	Major facilitator Superfamily
SBI_RS04370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SBI_RS04400	COG3835	regulator
SBI_RS04410	COG0443	Heat shock 70 kDa protein
SBI_RS04430	COG2186	Transcriptional regulator
SBI_RS04435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SBI_RS04445	COG1175	transmembrane transport
SBI_RS04450	COG0395	ABC-type sugar transport system, permease component
SBI_RS04470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SBI_RS04485	COG1609	Transcriptional regulator
SBI_RS04500	COG3250	beta-galactosidase activity
SBI_RS04515	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SBI_RS04515	COG1796	DNA polymerase
SBI_RS04535	COG2175	clavaminate synthase activity
SBI_RS04540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SBI_RS04550	COG1960	acyl-CoA dehydrogenase activity
SBI_RS04555	COG0235	Class ii aldolase
SBI_RS04585	COG0017	Asparaginyl-tRNA synthetase
SBI_RS04590	COG0069	glutamate synthase activity
SBI_RS04600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS04605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS04610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS04620	COG2814	Major facilitator Superfamily
SBI_RS04635	COG1349	DNA-binding transcription factor activity
SBI_RS04640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SBI_RS04645	COG0191	fructose-bisphosphate aldolase activity
SBI_RS04650	COG0477	Major facilitator Superfamily
SBI_RS04740	COG0596	Alpha beta hydrolase
SBI_RS04770	COG0189	ligase activity
SBI_RS04800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS04805	COG0542	response to heat
SBI_RS04820	COG0431	NADPH-dependent FMN reductase
SBI_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS04850	COG2226	methyltransferase
SBI_RS04855	COG3903	Transcriptional regulator
SBI_RS04855	COG3629	intracellular signal transduction
SBI_RS04870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SBI_RS04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS04900	COG0431	NADPH-dependent FMN reductase
SBI_RS04905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS04910	COG0747	negative chemotaxis
SBI_RS04915	COG1214	PFAM Peptidase M22, glycoprotease
SBI_RS04915	COG0456	acetyltransferase
SBI_RS04935	COG2197	response regulator
SBI_RS04945	COG0463	Glycosyl transferase, family 2
SBI_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS04970	COG0604	alcohol dehydrogenase
SBI_RS04970	COG3321	synthase
SBI_RS04995	COG2197	response regulator
SBI_RS05015	COG1846	Transcriptional regulator
SBI_RS05020	COG0697	spore germination
SBI_RS05040	COG3629	intracellular signal transduction
SBI_RS05040	COG3903	Transcriptional regulator
SBI_RS05050	COG1132	(ABC) transporter
SBI_RS05075	COG1357	PFAM Pentapeptide repeats (8 copies)
SBI_RS05080	COG3629	intracellular signal transduction
SBI_RS05080	COG3903	Transcriptional regulator
SBI_RS05130	COG0583	DNA-binding transcription factor activity
SBI_RS05140	COG3594	Acyltransferase
SBI_RS05180	COG0438	transferase activity, transferring glycosyl groups
SBI_RS05185	COG0438	transferase activity, transferring glycosyl groups
SBI_RS05285	COG1605	Chorismate mutase
SBI_RS05300	COG2070	2-Nitropropane dioxygenase
SBI_RS05310	COG2815	serine threonine protein kinase
SBI_RS05310	COG0515	serine threonine protein kinase
SBI_RS05330	COG1335	isochorismatase
SBI_RS05335	COG1960	acyl-CoA dehydrogenase activity
SBI_RS05345	COG1653	transport
SBI_RS05350	COG0395	ABC-type sugar transport system, permease component
SBI_RS05355	COG1175	transmembrane transport
SBI_RS05365	COG2376	Dihydroxyacetone kinase
SBI_RS05370	COG1461	Dihydroxyacetone kinase
SBI_RS05405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS05455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS05535	COG2826	transposase and inactivated derivatives, IS30 family
SBI_RS05555	COG0745	RESPONSE REGULATOR receiver
SBI_RS05560	COG1404	Belongs to the peptidase S8 family
SBI_RS05580	COG3293	Transposase
SBI_RS05635	COG2910	NAD(P)H-binding
SBI_RS05710	COG1309	transcriptional regulator
SBI_RS05715	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS05730	COG0604	alcohol dehydrogenase
SBI_RS05730	COG3321	synthase
SBI_RS05795	COG1733	regulation of RNA biosynthetic process
SBI_RS05800	COG4584	PFAM Integrase catalytic
SBI_RS05850	COG0583	DNA-binding transcription factor activity
SBI_RS05905	COG0583	DNA-binding transcription factor activity
SBI_RS05910	COG0697	spore germination
SBI_RS05935	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SBI_RS06000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SBI_RS06035	COG3845	ABC transporter
SBI_RS06045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SBI_RS06060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SBI_RS06070	COG2205	protein histidine kinase activity
SBI_RS06085	COG4171	peptide transport system, permease
SBI_RS06090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SBI_RS06095	COG3547	Transposase (IS116 IS110 IS902 family)
SBI_RS06105	COG1408	metallophosphoesterase
SBI_RS06120	COG3655	Transcriptional regulator
SBI_RS06140	COG0395	ABC-type sugar transport system, permease component
SBI_RS06170	COG0346	lactoylglutathione lyase activity
SBI_RS06240	COG0395	ABC-type sugar transport system, permease component
SBI_RS06245	COG1175	transmembrane transport
SBI_RS06280	COG2706	6-phosphogluconolactonase activity
SBI_RS06290	COG0800	Aldolase
SBI_RS06295	COG3833	ABC-type maltose transport systems, permease component
SBI_RS06300	COG1175	transmembrane transport
SBI_RS06310	COG1609	Transcriptional regulator
SBI_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS06320	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS06410	COG0667	Aldo Keto reductase
SBI_RS06425	COG0656	L-ascorbic acid biosynthetic process
SBI_RS06430	COG1064	alcohol dehydrogenase
SBI_RS06465	COG0517	IMP dehydrogenase activity
SBI_RS06465	COG0617	tRNA 3'-terminal CCA addition
SBI_RS06465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SBI_RS06490	COG2326	polyphosphate kinase activity
SBI_RS06520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS06530	COG3903	Transcriptional regulator
SBI_RS06530	COG3629	intracellular signal transduction
SBI_RS06555	COG0604	alcohol dehydrogenase
SBI_RS06590	COG2124	cytochrome p450
SBI_RS06595	COG0604	alcohol dehydrogenase
SBI_RS06595	COG3321	synthase
SBI_RS06600	COG3321	synthase
SBI_RS06600	COG0604	alcohol dehydrogenase
SBI_RS06630	COG0604	alcohol dehydrogenase
SBI_RS06630	COG3321	synthase
SBI_RS06680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SBI_RS06695	COG4977	sequence-specific DNA binding
SBI_RS06705	COG0745	RESPONSE REGULATOR receiver
SBI_RS06710	COG0642	Histidine kinase
SBI_RS06805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SBI_RS06810	COG1802	Transcriptional regulator
SBI_RS06820	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS06840	COG4608	Belongs to the ABC transporter superfamily
SBI_RS06845	COG0444	Belongs to the ABC transporter superfamily
SBI_RS06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS06895	COG1309	transcriptional regulator
SBI_RS06925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SBI_RS06930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SBI_RS06935	COG0254	rRNA binding
SBI_RS06945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SBI_RS06960	COG0701	Predicted permease
SBI_RS06990	COG3344	reverse transcriptase
SBI_RS07020	COG2986	histidine ammonia-lyase
SBI_RS07035	COG3547	Transposase (IS116 IS110 IS902 family)
SBI_RS07120	COG0028	Belongs to the TPP enzyme family
SBI_RS07130	COG0254	rRNA binding
SBI_RS07135	COG2801	Transposase and inactivated derivatives
SBI_RS07215	COG1846	Transcriptional regulator
SBI_RS07220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS07225	COG1335	isochorismatase
SBI_RS07230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS07260	COG1846	Transcriptional regulator
SBI_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS07320	COG0179	Fumarylacetoacetate (FAA) hydrolase
SBI_RS07325	COG3971	2-oxopent-4-enoate hydratase activity
SBI_RS07345	COG1942	4-Oxalocrotonate Tautomerase
SBI_RS07360	COG3321	synthase
SBI_RS07360	COG0604	alcohol dehydrogenase
SBI_RS07375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS07405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS07415	COG2271	Major facilitator Superfamily
SBI_RS07430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SBI_RS07460	COG4941	Belongs to the sigma-70 factor family
SBI_RS07465	COG3795	YCII-related domain
SBI_RS07550	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS07555	COG2814	Major facilitator Superfamily
SBI_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS07605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS07610	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS07615	COG1120	ATPase activity
SBI_RS07620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SBI_RS07625	COG2319	Wd-40 repeat
SBI_RS07625	COG4249	Peptidase C14 caspase catalytic subunit p20
SBI_RS07650	COG0515	serine threonine protein kinase
SBI_RS07665	COG0477	Major facilitator Superfamily
SBI_RS07680	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS07685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS07705	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS07720	COG0477	Major facilitator Superfamily
SBI_RS07775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SBI_RS07780	COG0668	transmembrane transport
SBI_RS07800	COG0438	transferase activity, transferring glycosyl groups
SBI_RS07820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SBI_RS07825	COG3224	Antibiotic biosynthesis monooxygenase
SBI_RS07835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS07855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS07875	COG1131	(ABC) transporter
SBI_RS07880	COG4585	Histidine kinase
SBI_RS07885	COG2197	response regulator
SBI_RS07895	COG0673	inositol 2-dehydrogenase activity
SBI_RS07900	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS07925	COG0673	inositol 2-dehydrogenase activity
SBI_RS07950	COG0667	Aldo Keto reductase
SBI_RS08010	COG2267	carboxylic ester hydrolase activity
SBI_RS08015	COG0667	Aldo Keto reductase
SBI_RS08030	COG3940	Belongs to the glycosyl hydrolase 43 family
SBI_RS08055	COG3458	cephalosporin-C deacetylase activity
SBI_RS08065	COG1132	(ABC) transporter
SBI_RS08075	COG1301	dicarboxylic acid transport
SBI_RS08090	COG1132	(ABC) transporter
SBI_RS08095	COG1132	(ABC) transporter
SBI_RS08110	COG1946	Acyl-CoA thioesterase
SBI_RS08120	COG2018	Roadblock/LC7 domain
SBI_RS08130	COG1881	PFAM PEBP family protein
SBI_RS08170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SBI_RS08180	COG4677	pectinesterase activity
SBI_RS08195	COG1940	carbohydrate kinase activity
SBI_RS08215	COG1960	acyl-CoA dehydrogenase activity
SBI_RS08220	COG1960	acyl-CoA dehydrogenase activity
SBI_RS08230	COG3572	ergothioneine biosynthetic process
SBI_RS08235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SBI_RS08245	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SBI_RS08265	COG3958	Transketolase
SBI_RS08270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SBI_RS08275	COG1132	(ABC) transporter
SBI_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS08295	COG1024	Enoyl-CoA hydratase
SBI_RS08315	COG0183	Belongs to the thiolase family
SBI_RS08320	COG1309	transcriptional regulator
SBI_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS08330	COG1960	acyl-CoA dehydrogenase activity
SBI_RS08335	COG1960	acyl-CoA dehydrogenase activity
SBI_RS08350	COG1960	acyl-CoA dehydrogenase activity
SBI_RS08370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SBI_RS08380	COG3360	Dodecin
SBI_RS08390	COG3959	Transketolase, thiamine diphosphate binding domain
SBI_RS08415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SBI_RS08435	COG3629	intracellular signal transduction
SBI_RS08480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SBI_RS08535	COG2814	Major facilitator Superfamily
SBI_RS08580	COG1172	Belongs to the binding-protein-dependent transport system permease family
SBI_RS08590	COG1846	Transcriptional regulator
SBI_RS08590	COG1940	carbohydrate kinase activity
SBI_RS08610	COG1175	transmembrane transport
SBI_RS08615	COG0395	ABC-type sugar transport system, permease component
SBI_RS08640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SBI_RS08640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SBI_RS08645	COG0730	response to heat
SBI_RS08650	COG1937	Protein conserved in bacteria
SBI_RS08665	COG0739	heme binding
SBI_RS08705	COG2362	D-Aminopeptidase
SBI_RS08715	COG0596	Alpha beta hydrolase
SBI_RS08725	COG1620	l-lactate permease
SBI_RS08735	COG2197	response regulator
SBI_RS08760	COG2186	Transcriptional regulator
SBI_RS08770	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS08805	COG0720	synthase
SBI_RS08815	COG0302	gtp cyclohydrolase
SBI_RS08820	COG0516	GMP reductase activity
SBI_RS08820	COG0517	IMP dehydrogenase activity
SBI_RS08830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SBI_RS08860	COG1846	Transcriptional regulator
SBI_RS08910	COG1609	Transcriptional regulator
SBI_RS08915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS08920	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS08925	COG0246	Mannitol dehydrogenase
SBI_RS08930	COG0477	Major facilitator Superfamily
SBI_RS08935	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SBI_RS08960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS08980	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS09000	COG0129	dihydroxy-acid dehydratase activity
SBI_RS09015	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SBI_RS09020	COG0714	Associated with various cellular activities
SBI_RS09040	COG2124	cytochrome p450
SBI_RS09050	COG0395	ABC-type sugar transport system, permease component
SBI_RS09055	COG1175	transmembrane transport
SBI_RS09065	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS09070	COG1609	Transcriptional regulator
SBI_RS09075	COG1609	Transcriptional regulator
SBI_RS09100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SBI_RS09115	COG3835	regulator
SBI_RS09120	COG0443	Heat shock 70 kDa protein
SBI_RS09125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SBI_RS09140	COG0542	response to heat
SBI_RS09155	COG3629	intracellular signal transduction
SBI_RS09155	COG3903	Transcriptional regulator
SBI_RS09215	COG1674	ftsk spoiiie
SBI_RS09225	COG0464	growth
SBI_RS09305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SBI_RS09335	COG3903	Transcriptional regulator
SBI_RS09335	COG3629	intracellular signal transduction
SBI_RS09345	COG2197	response regulator
SBI_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS09365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SBI_RS09375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS09380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS09385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS09405	COG5002	protein histidine kinase activity
SBI_RS09445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS09475	COG0346	lactoylglutathione lyase activity
SBI_RS09505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SBI_RS09510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS09515	COG1116	anion transmembrane transporter activity
SBI_RS09530	COG3321	synthase
SBI_RS09530	COG0604	alcohol dehydrogenase
SBI_RS09535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SBI_RS09550	COG0604	alcohol dehydrogenase
SBI_RS09550	COG3321	synthase
SBI_RS09555	COG0604	alcohol dehydrogenase
SBI_RS09555	COG3321	synthase
SBI_RS09565	COG3321	synthase
SBI_RS09565	COG0604	alcohol dehydrogenase
SBI_RS09590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SBI_RS09600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS09610	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SBI_RS09620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS09625	COG1937	Protein conserved in bacteria
SBI_RS09640	COG2018	Roadblock/LC7 domain
SBI_RS09675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SBI_RS09695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SBI_RS09700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SBI_RS09705	COG1984	allophanate hydrolase subunit 2
SBI_RS09720	COG0445	tRNA wobble uridine modification
SBI_RS09730	COG1660	Displays ATPase and GTPase activities
SBI_RS09735	COG0395	ABC-type sugar transport system, permease component
SBI_RS09740	COG1175	transmembrane transport
SBI_RS09750	COG3345	alpha-galactosidase
SBI_RS09755	COG0515	serine threonine protein kinase
SBI_RS09755	COG2815	serine threonine protein kinase
SBI_RS09790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SBI_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS09825	COG0584	glycerophosphoryl diester phosphodiesterase
SBI_RS09875	COG0671	phosphoesterase, PA-phosphatase related
SBI_RS09885	COG1309	transcriptional regulator
SBI_RS09905	COG2233	PERMEase
SBI_RS09910	COG0640	Transcriptional regulator
SBI_RS09915	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS09925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SBI_RS09945	COG2706	6-phosphogluconolactonase activity
SBI_RS09955	COG1522	sequence-specific DNA binding
SBI_RS09960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SBI_RS09985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SBI_RS10005	COG0671	phosphoesterase, PA-phosphatase related
SBI_RS10020	COG1733	regulation of RNA biosynthetic process
SBI_RS10030	COG0477	Major facilitator Superfamily
SBI_RS10035	COG0745	RESPONSE REGULATOR receiver
SBI_RS10040	COG2205	protein histidine kinase activity
SBI_RS10085	COG0745	RESPONSE REGULATOR receiver
SBI_RS10090	COG0438	transferase activity, transferring glycosyl groups
SBI_RS10120	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SBI_RS10125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SBI_RS10140	COG3345	alpha-galactosidase
SBI_RS10150	COG2133	pyrroloquinoline quinone binding
SBI_RS10155	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SBI_RS10175	COG0300	oxidoreductase activity
SBI_RS10185	COG1064	alcohol dehydrogenase
SBI_RS10195	COG2851	Citrate transporter
SBI_RS10200	COG0583	DNA-binding transcription factor activity
SBI_RS10205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SBI_RS10210	COG2301	Belongs to the HpcH HpaI aldolase family
SBI_RS10225	COG3209	COG3209 Rhs family protein
SBI_RS10230	COG0386	Belongs to the glutathione peroxidase family
SBI_RS10310	COG0395	ABC-type sugar transport system, permease component
SBI_RS10315	COG1175	transmembrane transport
SBI_RS10320	COG1653	transport
SBI_RS10325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SBI_RS10325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SBI_RS10335	COG1486	melibiose metabolic process
SBI_RS10340	COG1349	DNA-binding transcription factor activity
SBI_RS10355	COG0395	ABC-type sugar transport system, permease component
SBI_RS10360	COG1063	alcohol dehydrogenase
SBI_RS10375	COG0583	DNA-binding transcription factor activity
SBI_RS10405	COG1349	DNA-binding transcription factor activity
SBI_RS10410	COG3250	beta-galactosidase activity
SBI_RS10420	COG2814	Major facilitator Superfamily
SBI_RS10435	COG0514	ATP-dependent DNA helicase (RecQ)
SBI_RS10440	COG0326	Molecular chaperone. Has ATPase activity
SBI_RS10450	COG3458	cephalosporin-C deacetylase activity
SBI_RS10460	COG1271	oxidase subunit
SBI_RS10490	COG1609	Transcriptional regulator
SBI_RS10510	COG0444	Belongs to the ABC transporter superfamily
SBI_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS10520	COG0601	transmembrane transport
SBI_RS10525	COG0747	negative chemotaxis
SBI_RS10540	COG1129	ABC transporter
SBI_RS10545	COG1172	Belongs to the binding-protein-dependent transport system permease family
SBI_RS10550	COG4213	ABC transporter substrate-binding protein
SBI_RS10555	COG0673	inositol 2-dehydrogenase activity
SBI_RS10565	COG2197	response regulator
SBI_RS10570	COG3509	depolymerase
SBI_RS10600	COG2186	Transcriptional regulator
SBI_RS10605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS10620	COG1653	transport
SBI_RS10625	COG0395	ABC-type sugar transport system, permease component
SBI_RS10630	COG4209	transmembrane transport
SBI_RS10650	COG3345	alpha-galactosidase
SBI_RS10655	COG1940	carbohydrate kinase activity
SBI_RS10655	COG1846	Transcriptional regulator
SBI_RS10660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS10660	COG0515	serine threonine protein kinase
SBI_RS10680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SBI_RS10705	COG2409	Drug exporters of the RND superfamily
SBI_RS10710	COG4585	Histidine kinase
SBI_RS10715	COG1674	ftsk spoiiie
SBI_RS10730	COG2207	Transcriptional regulator
SBI_RS10755	COG2027	D-alanyl-D-alanine carboxypeptidase
SBI_RS10800	COG0745	RESPONSE REGULATOR receiver
SBI_RS10805	COG5002	protein histidine kinase activity
SBI_RS10815	COG0583	DNA-binding transcription factor activity
SBI_RS10835	COG0019	diaminopimelate decarboxylase activity
SBI_RS10840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SBI_RS10850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SBI_RS10855	COG1609	Transcriptional regulator
SBI_RS10865	COG0154	amidase activity
SBI_RS10870	COG0432	Pfam Uncharacterised protein family UPF0047
SBI_RS10875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS10880	COG1116	anion transmembrane transporter activity
SBI_RS10895	COG2197	response regulator
SBI_RS10900	COG4585	Histidine kinase
SBI_RS10930	COG3903	Transcriptional regulator
SBI_RS10930	COG3629	intracellular signal transduction
SBI_RS10945	COG3629	intracellular signal transduction
SBI_RS10945	COG3903	Transcriptional regulator
SBI_RS10970	COG1609	Transcriptional regulator
SBI_RS10985	COG1879	ABC-type sugar transport system periplasmic component
SBI_RS10990	COG1172	Belongs to the binding-protein-dependent transport system permease family
SBI_RS11000	COG1129	ABC transporter
SBI_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS11010	COG3347	Dehydrogenase
SBI_RS11015	COG1070	Carbohydrate kinase
SBI_RS11020	COG0247	lactate metabolic process
SBI_RS11025	COG1139	Iron-sulfur cluster binding protein
SBI_RS11030	COG1556	Lactate utilization protein
SBI_RS11040	COG0768	penicillin binding
SBI_RS11045	COG1940	carbohydrate kinase activity
SBI_RS11090	COG0436	Aminotransferase
SBI_RS11095	COG2364	Membrane
SBI_RS11105	COG3030	protein affecting phage T7 exclusion by the F plasmid
SBI_RS11110	COG0463	Glycosyl transferase, family 2
SBI_RS11135	COG1960	acyl-CoA dehydrogenase activity
SBI_RS11170	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS11180	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS11195	COG5001	Diguanylate cyclase
SBI_RS11245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SBI_RS11250	COG0140	phosphoribosyl-ATP diphosphatase activity
SBI_RS11255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SBI_RS11260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SBI_RS11260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SBI_RS11280	COG1940	carbohydrate kinase activity
SBI_RS11280	COG1846	Transcriptional regulator
SBI_RS11285	COG0738	Major facilitator superfamily
SBI_RS11295	COG2233	PERMEase
SBI_RS11320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SBI_RS11330	COG0531	amino acid
SBI_RS11350	COG2390	Transcriptional regulator
SBI_RS11355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SBI_RS11370	COG1132	(ABC) transporter
SBI_RS11375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SBI_RS11390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SBI_RS11415	COG0284	orotidine-5'-phosphate decarboxylase activity
SBI_RS11420	COG0167	dihydroorotate dehydrogenase activity
SBI_RS11425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SBI_RS11430	COG0505	Belongs to the CarA family
SBI_RS11440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SBI_RS11445	COG0540	Belongs to the ATCase OTCase family
SBI_RS11450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SBI_RS11460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SBI_RS11465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SBI_RS11470	COG0006	proline dipeptidase activity
SBI_RS11480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SBI_RS11485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SBI_RS11490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SBI_RS11495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SBI_RS11500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SBI_RS11510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SBI_RS11515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SBI_RS11530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SBI_RS11550	COG0124	histidyl-tRNA synthetase
SBI_RS11560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SBI_RS11565	COG1196	nuclear chromosome segregation
SBI_RS11570	COG0515	serine threonine protein kinase
SBI_RS11575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SBI_RS11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SBI_RS11585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SBI_RS11590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SBI_RS11600	COG2255	four-way junction helicase activity
SBI_RS11605	COG0632	four-way junction helicase activity
SBI_RS11610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SBI_RS11615	COG0217	transcriptional regulatory protein
SBI_RS11620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SBI_RS11625	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SBI_RS11635	COG0438	transferase activity, transferring glycosyl groups
SBI_RS11640	COG1560	Kdo2-lipid A biosynthetic process
SBI_RS11645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SBI_RS11665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SBI_RS11680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SBI_RS11705	COG0395	ABC-type sugar transport system, permease component
SBI_RS11710	COG1175	transmembrane transport
SBI_RS11715	COG1653	transport
SBI_RS11755	COG0454	-acetyltransferase
SBI_RS11755	COG0456	acetyltransferase
SBI_RS11765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SBI_RS11765	COG0512	Glutamine amidotransferase of anthranilate synthase
SBI_RS11855	COG0535	radical SAM domain protein
SBI_RS11860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SBI_RS11885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SBI_RS11885	COG1648	precorrin-2 dehydrogenase activity
SBI_RS11890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SBI_RS11910	COG1464	Belongs to the NlpA lipoprotein family
SBI_RS11915	COG1464	Belongs to the NlpA lipoprotein family
SBI_RS11920	COG2011	ABC-type metal ion transport system permease component
SBI_RS11960	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS11960	COG0204	Acyl-transferase
SBI_RS11980	COG0165	Argininosuccinate lyase
SBI_RS11985	COG0137	argininosuccinate synthase activity
SBI_RS12035	COG0385	Bile acid
SBI_RS12040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SBI_RS12055	COG3842	ATPase activity
SBI_RS12060	COG3833	ABC-type maltose transport systems, permease component
SBI_RS12065	COG1176	ABC-type spermidine putrescine transport system, permease component I
SBI_RS12070	COG1609	Transcriptional regulator
SBI_RS12075	COG1438	arginine binding
SBI_RS12080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SBI_RS12085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SBI_RS12090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SBI_RS12095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SBI_RS12100	COG2838	Isocitrate dehydrogenase
SBI_RS12120	COG0431	NADPH-dependent FMN reductase
SBI_RS12145	COG1120	ATPase activity
SBI_RS12150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS12160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SBI_RS12180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SBI_RS12185	COG0697	spore germination
SBI_RS12195	COG1649	PFAM Uncharacterised BCR, COG1649
SBI_RS12295	COG2205	protein histidine kinase activity
SBI_RS12310	COG0659	secondary active sulfate transmembrane transporter activity
SBI_RS12320	COG1051	belongs to the nudix hydrolase family
SBI_RS12335	COG0072	phenylalanine-tRNA ligase activity
SBI_RS12335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SBI_RS12340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SBI_RS12345	COG5002	protein histidine kinase activity
SBI_RS12350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SBI_RS12355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SBI_RS12360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SBI_RS12365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SBI_RS12375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SBI_RS12415	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS12430	COG0531	amino acid
SBI_RS12435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SBI_RS12500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SBI_RS12530	COG2755	lipolytic protein G-D-S-L family
SBI_RS12550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SBI_RS12555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SBI_RS12570	COG1657	PFAM Prenyltransferase squalene oxidase
SBI_RS12580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SBI_RS12590	COG1562	ergosterol biosynthetic process
SBI_RS12610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS12620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS12625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS12640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS12650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS12655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SBI_RS12660	COG0736	holo-[acyl-carrier-protein] synthase activity
SBI_RS12675	COG2409	Drug exporters of the RND superfamily
SBI_RS12690	COG2124	cytochrome p450
SBI_RS12695	COG2124	cytochrome p450
SBI_RS12710	COG1134	teichoic acid transport
SBI_RS12730	COG0371	Dehydrogenase
SBI_RS12755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SBI_RS12795	COG2183	response to ionizing radiation
SBI_RS12800	COG0488	(ABC) transporter
SBI_RS12820	COG2936	dipeptidyl-peptidase activity
SBI_RS12840	COG3250	beta-galactosidase activity
SBI_RS12850	COG1250	3-hydroxyacyl-CoA dehydrogenase
SBI_RS12850	COG1024	Enoyl-CoA hydratase
SBI_RS12855	COG0183	Belongs to the thiolase family
SBI_RS12860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SBI_RS12870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS12880	COG1515	deoxyribonuclease V activity
SBI_RS12930	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS12935	COG1404	Belongs to the peptidase S8 family
SBI_RS12955	COG1414	Transcriptional regulator
SBI_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS13030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SBI_RS13045	COG1819	glycosyl
SBI_RS13065	COG1349	DNA-binding transcription factor activity
SBI_RS13080	COG0366	Alpha amylase catalytic
SBI_RS13080	COG1470	cell adhesion involved in biofilm formation
SBI_RS13085	COG0366	Alpha amylase catalytic
SBI_RS13085	COG1470	cell adhesion involved in biofilm formation
SBI_RS13135	COG0492	ferredoxin-NADP+ reductase activity
SBI_RS13150	COG1414	Transcriptional regulator
SBI_RS13190	COG0045	succinate-CoA ligase (ADP-forming) activity
SBI_RS13200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SBI_RS13215	COG4221	oxidoreductase activity
SBI_RS13225	COG0222	ribosome binding
SBI_RS13245	COG3383	formate dehydrogenase (NAD+) activity
SBI_RS13260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SBI_RS13265	COG1309	transcriptional regulator
SBI_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS13290	COG0789	Transcriptional regulator
SBI_RS13320	COG0656	L-ascorbic acid biosynthetic process
SBI_RS13330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SBI_RS13340	COG2154	pterin-4-alpha-carbinolamine dehydratase
SBI_RS13365	COG0531	amino acid
SBI_RS13405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SBI_RS13425	COG2329	Antibiotic biosynthesis monooxygenase
SBI_RS13445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS13465	COG0511	ligase activity, forming carbon-carbon bonds
SBI_RS13470	COG0439	Biotin carboxylase
SBI_RS13510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS13515	COG0028	Belongs to the TPP enzyme family
SBI_RS13535	COG4106	trans-aconitate 2-methyltransferase activity
SBI_RS13565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS13570	COG2362	D-Aminopeptidase
SBI_RS13575	COG1063	alcohol dehydrogenase
SBI_RS13585	COG2197	response regulator
SBI_RS13625	COG1131	(ABC) transporter
SBI_RS13630	COG0745	RESPONSE REGULATOR receiver
SBI_RS13635	COG2205	protein histidine kinase activity
SBI_RS13640	COG2205	protein histidine kinase activity
SBI_RS13645	COG0745	RESPONSE REGULATOR receiver
SBI_RS13655	COG0477	Major facilitator Superfamily
SBI_RS13660	COG1733	regulation of RNA biosynthetic process
SBI_RS13665	COG0778	Nitroreductase
SBI_RS13680	COG0167	dihydroorotate dehydrogenase activity
SBI_RS13700	COG0504	CTP synthase activity
SBI_RS13710	COG1366	Belongs to the anti-sigma-factor antagonist family
SBI_RS13710	COG2208	phosphoserine phosphatase activity
SBI_RS13710	COG2172	sigma factor antagonist activity
SBI_RS13745	COG0789	Transcriptional regulator
SBI_RS13770	COG1309	transcriptional regulator
SBI_RS13775	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS13790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS13790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS13795	COG2301	Belongs to the HpcH HpaI aldolase family
SBI_RS13805	COG1960	acyl-CoA dehydrogenase activity
SBI_RS13810	COG0688	phosphatidylethanolamine metabolic process
SBI_RS13820	COG1929	Belongs to the glycerate kinase type-1 family
SBI_RS13825	COG1397	ADP-ribosylglycohydrolase
SBI_RS13835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SBI_RS13845	COG1595	DNA-templated transcription, initiation
SBI_RS13850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SBI_RS13880	COG0181	hydroxymethylbilane synthase activity
SBI_RS13885	COG0384	phenazine biosynthesis protein PhzF
SBI_RS13890	COG0583	DNA-binding transcription factor activity
SBI_RS13905	COG0483	inositol monophosphate 1-phosphatase activity
SBI_RS13910	COG1228	amidohydrolase
SBI_RS13915	COG0604	alcohol dehydrogenase
SBI_RS13930	COG2207	Transcriptional regulator
SBI_RS13935	COG2223	nitrite transmembrane transporter activity
SBI_RS13950	COG3394	polysaccharide catabolic process
SBI_RS14015	COG0095	Lipoate-protein ligase
SBI_RS14025	COG1953	Uracil, thiamine, allantoin
SBI_RS14035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SBI_RS14040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SBI_RS14060	COG0405	Gamma-glutamyltransferase
SBI_RS14080	COG1017	nitric oxide dioxygenase activity
SBI_RS14080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SBI_RS14085	COG0745	RESPONSE REGULATOR receiver
SBI_RS14090	COG2205	protein histidine kinase activity
SBI_RS14100	COG0765	amino acid transport
SBI_RS14105	COG0765	amino acid transport
SBI_RS14110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SBI_RS14115	COG1126	abc transporter atp-binding protein
SBI_RS14140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS14150	COG1940	carbohydrate kinase activity
SBI_RS14170	COG2188	Transcriptional regulator
SBI_RS14175	COG4608	Belongs to the ABC transporter superfamily
SBI_RS14180	COG0444	Belongs to the ABC transporter superfamily
SBI_RS14185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS14190	COG0601	transmembrane transport
SBI_RS14210	COG1228	amidohydrolase
SBI_RS14215	COG1846	Transcriptional regulator
SBI_RS14225	COG0583	DNA-binding transcription factor activity
SBI_RS14235	COG0800	Aldolase
SBI_RS14275	COG1595	DNA-templated transcription, initiation
SBI_RS14280	COG1252	NADH dehydrogenase
SBI_RS14290	COG4266	Belongs to the allantoicase family
SBI_RS14295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SBI_RS14300	COG1414	Transcriptional regulator
SBI_RS14315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SBI_RS14325	COG2205	protein histidine kinase activity
SBI_RS14330	COG0745	RESPONSE REGULATOR receiver
SBI_RS14370	COG2351	hydroxyisourate hydrolase activity
SBI_RS14405	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS14410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS14415	COG2197	response regulator
SBI_RS14420	COG0598	Magnesium transport protein CorA
SBI_RS14430	COG2755	lipolytic protein G-D-S-L family
SBI_RS14440	COG2197	response regulator
SBI_RS14450	COG0667	Aldo Keto reductase
SBI_RS14485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SBI_RS14510	COG1802	Transcriptional regulator
SBI_RS14530	COG0028	Belongs to the TPP enzyme family
SBI_RS14545	COG1162	GTPase activity
SBI_RS14560	COG2175	clavaminate synthase activity
SBI_RS14565	COG1819	glycosyl
SBI_RS14600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SBI_RS14615	COG1940	carbohydrate kinase activity
SBI_RS14625	COG3629	intracellular signal transduction
SBI_RS14625	COG3903	Transcriptional regulator
SBI_RS14645	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SBI_RS14675	COG0175	sulfate reduction
SBI_RS14680	COG0529	Catalyzes the synthesis of activated sulfate
SBI_RS14700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SBI_RS14705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS14745	COG1764	response to oxidative stress
SBI_RS14770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SBI_RS14785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SBI_RS14810	COG1175	transmembrane transport
SBI_RS14825	COG1802	Transcriptional regulator
SBI_RS14830	COG1119	ATPase activity
SBI_RS14870	COG0583	DNA-binding transcription factor activity
SBI_RS14875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SBI_RS14890	COG2197	response regulator
SBI_RS14925	COG3693	PFAM glycoside hydrolase, family 10
SBI_RS14930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SBI_RS14935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SBI_RS14970	COG3842	ATPase activity
SBI_RS14995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SBI_RS15000	COG3220	belongs to the UPF0276 family
SBI_RS15020	COG3253	May function as heme-dependent peroxidase
SBI_RS15060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SBI_RS15080	COG0183	Belongs to the thiolase family
SBI_RS15085	COG1024	Enoyl-CoA hydratase
SBI_RS15085	COG1250	3-hydroxyacyl-CoA dehydrogenase
SBI_RS15100	COG0702	epimerase
SBI_RS15140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS15145	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS15150	COG1120	ATPase activity
SBI_RS15155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SBI_RS15160	COG0531	amino acid
SBI_RS15165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SBI_RS15170	COG4214	carbohydrate transport
SBI_RS15180	COG4213	ABC transporter substrate-binding protein
SBI_RS15210	COG1960	acyl-CoA dehydrogenase activity
SBI_RS15250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS15260	COG0395	ABC-type sugar transport system, permease component
SBI_RS15265	COG1175	transmembrane transport
SBI_RS15270	COG1653	transport
SBI_RS15335	COG2814	Major facilitator Superfamily
SBI_RS15340	COG0789	Transcriptional regulator
SBI_RS15360	COG1802	Transcriptional regulator
SBI_RS15365	COG3938	Belongs to the proline racemase family
SBI_RS15375	COG0006	proline dipeptidase activity
SBI_RS15395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS15435	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS15445	COG0667	Aldo Keto reductase
SBI_RS15460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SBI_RS15465	COG4106	trans-aconitate 2-methyltransferase activity
SBI_RS15470	COG2843	Capsule synthesis protein
SBI_RS15480	COG0640	Transcriptional regulator
SBI_RS15495	COG0477	Major facilitator Superfamily
SBI_RS15505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS15510	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS15530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS15545	COG3537	Alpha-1,2-mannosidase
SBI_RS15565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SBI_RS15600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SBI_RS15605	COG1120	ATPase activity
SBI_RS15610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS15655	COG2318	DinB family
SBI_RS15665	COG1024	Enoyl-CoA hydratase
SBI_RS15680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SBI_RS15710	COG4977	sequence-specific DNA binding
SBI_RS15715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SBI_RS15725	COG2040	homocysteine
SBI_RS15790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SBI_RS15815	COG0725	ABC transporter, periplasmic molybdate-binding protein
SBI_RS15830	COG0243	molybdopterin cofactor binding
SBI_RS15855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SBI_RS15860	COG0531	amino acid
SBI_RS15890	COG0569	domain protein
SBI_RS15930	COG0756	dUTP diphosphatase activity
SBI_RS15955	COG2205	protein histidine kinase activity
SBI_RS15960	COG0745	RESPONSE REGULATOR receiver
SBI_RS15975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SBI_RS16005	COG1435	thymidine kinase activity
SBI_RS16025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SBI_RS16030	COG1802	Transcriptional regulator
SBI_RS16045	COG0612	Peptidase, M16
SBI_RS16050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SBI_RS16055	COG0596	Alpha beta hydrolase
SBI_RS16060	COG3629	intracellular signal transduction
SBI_RS16060	COG3903	Transcriptional regulator
SBI_RS16075	COG3290	protein histidine kinase activity
SBI_RS16080	COG4565	transcriptional regulatory protein
SBI_RS16085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SBI_RS16095	COG2197	response regulator
SBI_RS16100	COG0187	DNA topoisomerase II activity
SBI_RS16115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SBI_RS16120	COG1802	Transcriptional regulator
SBI_RS16125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SBI_RS16155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SBI_RS16165	COG0406	alpha-ribazole phosphatase activity
SBI_RS16175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SBI_RS16180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SBI_RS16185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SBI_RS16210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SBI_RS16220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SBI_RS16225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SBI_RS16235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SBI_RS16250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SBI_RS16260	COG2205	protein histidine kinase activity
SBI_RS16270	COG1126	abc transporter atp-binding protein
SBI_RS16275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SBI_RS16280	COG0765	amino acid transport
SBI_RS16285	COG0765	amino acid transport
SBI_RS16310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SBI_RS16345	COG1201	RNA secondary structure unwinding
SBI_RS16350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SBI_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS16360	COG1396	sequence-specific DNA binding
SBI_RS16365	COG1058	Belongs to the CinA family
SBI_RS16365	COG1546	Belongs to the CinA family
SBI_RS16375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SBI_RS16385	COG1674	ftsk spoiiie
SBI_RS16400	COG2770	Histidine kinase
SBI_RS16400	COG2208	phosphoserine phosphatase activity
SBI_RS16430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SBI_RS16435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS16440	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SBI_RS16460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SBI_RS16465	COG0612	Peptidase, M16
SBI_RS16470	COG1185	polyribonucleotide nucleotidyltransferase activity
SBI_RS16475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SBI_RS16485	COG1674	ftsk spoiiie
SBI_RS16565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS16565	COG0515	serine threonine protein kinase
SBI_RS16575	COG1404	Belongs to the peptidase S8 family
SBI_RS16580	COG3266	domain, Protein
SBI_RS16605	COG0455	bacterial-type flagellum organization
SBI_RS16615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SBI_RS16620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SBI_RS16630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SBI_RS16645	COG0779	Required for maturation of 30S ribosomal subunits
SBI_RS16665	COG0442	prolyl-tRNA aminoacylation
SBI_RS16680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SBI_RS16685	COG0750	zinc metalloprotease
SBI_RS16690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SBI_RS16710	COG2409	Drug exporters of the RND superfamily
SBI_RS16715	COG2197	response regulator
SBI_RS16720	COG4585	Histidine kinase
SBI_RS16735	COG0395	ABC-type sugar transport system, permease component
SBI_RS16740	COG4209	transmembrane transport
SBI_RS16750	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS16755	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS16760	COG2508	Transcriptional regulator
SBI_RS16770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SBI_RS16800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SBI_RS16815	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS16820	COG1136	(ABC) transporter
SBI_RS16840	COG3842	ATPase activity
SBI_RS16855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SBI_RS16860	COG0575	Belongs to the CDS family
SBI_RS16865	COG0233	cytoplasmic translational termination
SBI_RS16870	COG0528	UMP kinase activity
SBI_RS16875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SBI_RS16880	COG0052	Belongs to the universal ribosomal protein uS2 family
SBI_RS16895	COG1191	sigma factor activity
SBI_RS16910	COG0792	nuclease activity
SBI_RS16925	COG0681	Belongs to the peptidase S26 family
SBI_RS16935	COG0681	Belongs to the peptidase S26 family
SBI_RS16940	COG0681	Belongs to the peptidase S26 family
SBI_RS16945	COG0336	Belongs to the RNA methyltransferase TrmD family
SBI_RS16950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SBI_RS16955	COG1837	Belongs to the UPF0109 family
SBI_RS16960	COG0228	four-way junction DNA binding
SBI_RS16970	COG0442	prolyl-tRNA aminoacylation
SBI_RS16985	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SBI_RS17015	COG2197	response regulator
SBI_RS17020	COG4585	Histidine kinase
SBI_RS17040	COG0477	Major facilitator Superfamily
SBI_RS17045	COG1196	nuclear chromosome segregation
SBI_RS17055	COG1254	Belongs to the acylphosphatase family
SBI_RS17060	COG2340	Cysteine-rich secretory protein family
SBI_RS17065	COG1733	regulation of RNA biosynthetic process
SBI_RS17070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SBI_RS17075	COG0571	ribonuclease III activity
SBI_RS17080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SBI_RS17095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SBI_RS17100	COG0742	ribosomal rna small subunit methyltransferase
SBI_RS17105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SBI_RS17110	COG1461	Dihydroxyacetone kinase
SBI_RS17115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SBI_RS17120	COG0351	phosphomethylpyrimidine kinase
SBI_RS17140	COG1181	Belongs to the D-alanine--D-alanine ligase family
SBI_RS17145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SBI_RS17155	COG1920	GTP binding
SBI_RS17165	COG0776	regulation of translation
SBI_RS17175	COG0066	3-isopropylmalate dehydratase activity
SBI_RS17180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SBI_RS17185	COG1414	Transcriptional regulator
SBI_RS17225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SBI_RS17230	COG0179	Fumarylacetoacetate (FAA) hydrolase
SBI_RS17240	COG5002	protein histidine kinase activity
SBI_RS17245	COG2018	Roadblock/LC7 domain
SBI_RS17265	COG2018	Roadblock/LC7 domain
SBI_RS17285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SBI_RS17295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SBI_RS17300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SBI_RS17305	COG0473	3-isopropylmalate dehydrogenase activity
SBI_RS17315	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS17320	COG0506	proline dehydrogenase activity
SBI_RS17345	COG0477	Major facilitator Superfamily
SBI_RS17380	COG3467	pyridoxamine 5'-phosphate
SBI_RS17420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SBI_RS17425	COG0440	acetolactate synthase activity
SBI_RS17445	COG0667	Aldo Keto reductase
SBI_RS17450	COG2133	pyrroloquinoline quinone binding
SBI_RS17460	COG1672	PFAM Archaeal ATPase
SBI_RS17460	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SBI_RS17480	COG2409	Drug exporters of the RND superfamily
SBI_RS17495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SBI_RS17505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SBI_RS17515	COG0154	amidase activity
SBI_RS17520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SBI_RS17530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SBI_RS17545	COG1846	Transcriptional regulator
SBI_RS17550	COG4221	oxidoreductase activity
SBI_RS17555	COG3903	Transcriptional regulator
SBI_RS17555	COG3629	intracellular signal transduction
SBI_RS17630	COG0482	sulfurtransferase activity
SBI_RS17635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS17655	COG0596	Alpha beta hydrolase
SBI_RS17665	COG2860	membrane
SBI_RS17670	COG4608	Belongs to the ABC transporter superfamily
SBI_RS17675	COG0444	Belongs to the ABC transporter superfamily
SBI_RS17685	COG4166	transmembrane transport
SBI_RS17715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SBI_RS17720	COG0509	glycine decarboxylation via glycine cleavage system
SBI_RS17725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SBI_RS17730	COG1760	l-serine dehydratase
SBI_RS17770	COG0384	phenazine biosynthesis protein PhzF
SBI_RS17795	COG0395	ABC-type sugar transport system, permease component
SBI_RS17800	COG1175	transmembrane transport
SBI_RS17810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SBI_RS17840	COG0640	Transcriptional regulator
SBI_RS17925	COG1132	(ABC) transporter
SBI_RS17930	COG1132	(ABC) transporter
SBI_RS17965	COG3340	Belongs to the peptidase S51 family
SBI_RS17970	COG2318	DinB family
SBI_RS18000	COG0789	Transcriptional regulator
SBI_RS18015	COG0667	Aldo Keto reductase
SBI_RS18020	COG1280	lysine exporter protein (LysE YggA)
SBI_RS18025	COG4585	Histidine kinase
SBI_RS18030	COG3401	FG-GAP repeat protein
SBI_RS18050	COG0366	Alpha amylase catalytic
SBI_RS18065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SBI_RS18075	COG3629	intracellular signal transduction
SBI_RS18075	COG3903	Transcriptional regulator
SBI_RS18085	COG2319	Wd-40 repeat
SBI_RS18085	COG4249	Peptidase C14 caspase catalytic subunit p20
SBI_RS18090	COG1301	dicarboxylic acid transport
SBI_RS18095	COG3290	protein histidine kinase activity
SBI_RS18100	COG4565	transcriptional regulatory protein
SBI_RS18105	COG3469	chitinase activity
SBI_RS18115	COG1175	transmembrane transport
SBI_RS18145	COG1522	sequence-specific DNA binding
SBI_RS18200	COG2050	protein possibly involved in aromatic compounds catabolism
SBI_RS18210	COG0667	Aldo Keto reductase
SBI_RS18215	COG0583	DNA-binding transcription factor activity
SBI_RS18240	COG3833	ABC-type maltose transport systems, permease component
SBI_RS18260	COG0205	6-phosphofructokinase activity
SBI_RS18265	COG0857	belongs to the CobB CobQ family
SBI_RS18265	COG0280	phosphate acetyltransferase
SBI_RS18270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SBI_RS18305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS18305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS18360	COG0384	phenazine biosynthesis protein PhzF
SBI_RS18370	COG0183	Belongs to the thiolase family
SBI_RS18420	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SBI_RS18435	COG1250	3-hydroxyacyl-CoA dehydrogenase
SBI_RS18470	COG2197	response regulator
SBI_RS18480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SBI_RS18485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SBI_RS18490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SBI_RS18495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SBI_RS18500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SBI_RS18505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SBI_RS18510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SBI_RS18530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SBI_RS18535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SBI_RS18545	COG2890	protein-(glutamine-N5) methyltransferase activity
SBI_RS18550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SBI_RS18555	COG0254	rRNA binding
SBI_RS18570	COG0083	homoserine kinase activity
SBI_RS18575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SBI_RS18580	COG0460	homoserine dehydrogenase
SBI_RS18585	COG0019	diaminopimelate decarboxylase activity
SBI_RS18590	COG0018	arginyl-trna synthetase
SBI_RS18595	COG0745	RESPONSE REGULATOR receiver
SBI_RS18615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SBI_RS18655	COG0515	serine threonine protein kinase
SBI_RS18655	COG2815	serine threonine protein kinase
SBI_RS18710	COG4585	Histidine kinase
SBI_RS18875	COG2353	YceI-like domain
SBI_RS18905	COG3883	PFAM NLP P60 protein
SBI_RS18905	COG0791	NLP P60 protein
SBI_RS18950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SBI_RS18955	COG1595	DNA-templated transcription, initiation
SBI_RS18990	COG0745	RESPONSE REGULATOR receiver
SBI_RS18995	COG2205	protein histidine kinase activity
SBI_RS19000	COG0567	Dehydrogenase, E1 component
SBI_RS19000	COG0508	dehydrogenase complex catalyzes the overall conversion of
SBI_RS19060	COG1309	transcriptional regulator
SBI_RS19065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SBI_RS19090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SBI_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS19125	COG1309	transcriptional regulator
SBI_RS19150	COG0778	Nitroreductase
SBI_RS19165	COG0300	oxidoreductase activity
SBI_RS19165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS19165	COG3321	synthase
SBI_RS19165	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS19190	COG0604	alcohol dehydrogenase
SBI_RS19195	COG0281	malic enzyme
SBI_RS19200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SBI_RS19205	COG0765	amino acid transport
SBI_RS19210	COG1126	abc transporter atp-binding protein
SBI_RS19275	COG0583	DNA-binding transcription factor activity
SBI_RS19305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS19325	COG2066	Belongs to the glutaminase family
SBI_RS19345	COG2172	sigma factor antagonist activity
SBI_RS19360	COG1597	lipid kinase activity
SBI_RS19375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SBI_RS19380	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS19385	COG0395	ABC-type sugar transport system, permease component
SBI_RS19390	COG1175	transmembrane transport
SBI_RS19395	COG2182	Extracellular solute-binding protein
SBI_RS19400	COG2188	Transcriptional regulator
SBI_RS19420	COG0477	Major facilitator Superfamily
SBI_RS19430	COG1309	transcriptional regulator
SBI_RS19440	COG1733	regulation of RNA biosynthetic process
SBI_RS19455	COG1234	tRNA 3'-trailer cleavage
SBI_RS19475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SBI_RS19485	COG0640	Transcriptional regulator
SBI_RS19560	COG1349	DNA-binding transcription factor activity
SBI_RS19565	COG0588	phosphoglycerate mutase activity
SBI_RS19585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SBI_RS19600	COG0242	peptide deformylase activity
SBI_RS19615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SBI_RS19615	COG2199	diguanylate cyclase activity
SBI_RS19620	COG5662	AntiSigma factor
SBI_RS19625	COG1595	DNA-templated transcription, initiation
SBI_RS19635	COG2135	peptidase activity
SBI_RS19645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SBI_RS19650	COG1162	GTPase activity
SBI_RS19655	COG2076	Multidrug Resistance protein
SBI_RS19665	COG0483	inositol monophosphate 1-phosphatase activity
SBI_RS19695	COG1615	UPF0182 protein
SBI_RS19705	COG3480	Lon protease (S16) C-terminal proteolytic domain
SBI_RS19755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SBI_RS19795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SBI_RS19805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS19815	COG0210	DNA helicase
SBI_RS19905	COG0513	Belongs to the DEAD box helicase family
SBI_RS19915	COG1432	Conserved Protein
SBI_RS19920	COG0613	PHP domain protein
SBI_RS19935	COG0598	Magnesium transport protein CorA
SBI_RS19975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SBI_RS19980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SBI_RS19990	COG1595	DNA-templated transcription, initiation
SBI_RS20000	COG1024	Enoyl-CoA hydratase
SBI_RS20005	COG0519	Catalyzes the synthesis of GMP from XMP
SBI_RS20020	COG1611	Belongs to the LOG family
SBI_RS20025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS20065	COG1131	(ABC) transporter
SBI_RS20080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SBI_RS20100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS20105	COG0747	negative chemotaxis
SBI_RS20120	COG4608	Belongs to the ABC transporter superfamily
SBI_RS20130	COG1940	carbohydrate kinase activity
SBI_RS20130	COG1846	Transcriptional regulator
SBI_RS20135	COG1175	transmembrane transport
SBI_RS20155	COG4608	Belongs to the ABC transporter superfamily
SBI_RS20160	COG0444	Belongs to the ABC transporter superfamily
SBI_RS20165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS20170	COG0601	transmembrane transport
SBI_RS20175	COG4166	transmembrane transport
SBI_RS20185	COG0604	alcohol dehydrogenase
SBI_RS20210	COG4608	Belongs to the ABC transporter superfamily
SBI_RS20215	COG0444	Belongs to the ABC transporter superfamily
SBI_RS20220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS20225	COG0601	transmembrane transport
SBI_RS20235	COG1217	gtp-binding protein TYPA
SBI_RS20290	COG0531	amino acid
SBI_RS20315	COG0583	DNA-binding transcription factor activity
SBI_RS20335	COG0012	GTP binding
SBI_RS20350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SBI_RS20355	COG1570	exodeoxyribonuclease VII activity
SBI_RS20360	COG1722	exodeoxyribonuclease VII activity
SBI_RS20365	COG0778	Nitroreductase
SBI_RS20390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SBI_RS20390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SBI_RS20395	COG3469	chitinase activity
SBI_RS20410	COG0114	fumarate hydratase activity
SBI_RS20420	COG2264	protein methyltransferase activity
SBI_RS20430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SBI_RS20450	COG1136	(ABC) transporter
SBI_RS20470	COG0450	alkyl hydroperoxide reductase
SBI_RS20475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS20495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SBI_RS20500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SBI_RS20515	COG1278	Cold shock
SBI_RS20525	COG2885	chlorophyll binding
SBI_RS20565	COG2894	cell division
SBI_RS20590	COG0702	epimerase
SBI_RS20595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS20605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SBI_RS20630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SBI_RS20690	COG2610	gluconate transmembrane transporter activity
SBI_RS20695	COG0251	oxidation-reduction process
SBI_RS20700	COG1414	Transcriptional regulator
SBI_RS20705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS20715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SBI_RS20735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS20740	COG0601	transmembrane transport
SBI_RS20770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SBI_RS20775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS20790	COG3226	Transcriptional regulator
SBI_RS20795	COG0154	amidase activity
SBI_RS20810	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS20820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SBI_RS20865	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SBI_RS20870	COG1272	protein, Hemolysin III
SBI_RS20875	COG0477	Major facilitator Superfamily
SBI_RS20885	COG1331	Highly conserved protein containing a thioredoxin domain
SBI_RS20900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SBI_RS20910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SBI_RS20925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SBI_RS20930	COG2255	four-way junction helicase activity
SBI_RS20955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SBI_RS21010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SBI_RS21015	COG1733	regulation of RNA biosynthetic process
SBI_RS21035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SBI_RS21050	COG2018	Roadblock/LC7 domain
SBI_RS21055	COG5002	protein histidine kinase activity
SBI_RS21135	COG2161	toxin-antitoxin pair type II binding
SBI_RS21180	COG2084	Dehydrogenase
SBI_RS21185	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS21190	COG0149	triose-phosphate isomerase activity
SBI_RS21195	COG0698	ribose 5-phosphate isomerase
SBI_RS21200	COG2376	Dihydroxyacetone kinase
SBI_RS21210	COG2186	Transcriptional regulator
SBI_RS21235	COG0577	efflux transmembrane transporter activity
SBI_RS21240	COG1136	(ABC) transporter
SBI_RS21245	COG2814	Major facilitator Superfamily
SBI_RS21285	COG4585	Histidine kinase
SBI_RS21295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SBI_RS21300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SBI_RS21305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SBI_RS21310	COG0193	aminoacyl-tRNA hydrolase activity
SBI_RS21320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SBI_RS21350	COG4106	trans-aconitate 2-methyltransferase activity
SBI_RS21360	COG2197	response regulator
SBI_RS21365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SBI_RS21400	COG0488	(ABC) transporter
SBI_RS21410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SBI_RS21415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SBI_RS21425	COG0084	hydrolase, TatD family'
SBI_RS21455	COG4166	transmembrane transport
SBI_RS21470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SBI_RS21500	COG1131	(ABC) transporter
SBI_RS21505	COG4585	Histidine kinase
SBI_RS21510	COG2197	response regulator
SBI_RS21530	COG1122	ATPase activity
SBI_RS21540	COG0310	cobalt ion transport
SBI_RS21545	COG2409	Drug exporters of the RND superfamily
SBI_RS21555	COG4946	Tricorn protease homolog
SBI_RS21555	COG0793	Belongs to the peptidase S41A family
SBI_RS21570	COG2267	carboxylic ester hydrolase activity
SBI_RS21575	COG2072	flavoprotein involved in K transport
SBI_RS21635	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS21635	COG3321	synthase
SBI_RS21635	COG0604	alcohol dehydrogenase
SBI_RS21650	COG0395	ABC-type sugar transport system, permease component
SBI_RS21655	COG1175	transmembrane transport
SBI_RS21770	COG1695	Transcriptional regulator
SBI_RS21795	COG0583	DNA-binding transcription factor activity
SBI_RS21800	COG2329	Antibiotic biosynthesis monooxygenase
SBI_RS21825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SBI_RS21830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SBI_RS21830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SBI_RS21830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SBI_RS21840	COG1482	cell wall glycoprotein biosynthetic process
SBI_RS21855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SBI_RS21890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SBI_RS21895	COG0778	Nitroreductase
SBI_RS21895	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SBI_RS21910	COG4585	Histidine kinase
SBI_RS21915	COG2197	response regulator
SBI_RS21945	COG2205	protein histidine kinase activity
SBI_RS21955	COG0702	epimerase
SBI_RS21970	COG1136	(ABC) transporter
SBI_RS21970	COG0577	efflux transmembrane transporter activity
SBI_RS22010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SBI_RS22055	COG1316	TRANSCRIPTIONal
SBI_RS22070	COG1316	TRANSCRIPTIONal
SBI_RS22085	COG1316	TRANSCRIPTIONal
SBI_RS22095	COG1131	(ABC) transporter
SBI_RS22105	COG2315	Protein conserved in bacteria
SBI_RS22120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SBI_RS22170	COG2205	protein histidine kinase activity
SBI_RS22175	COG0745	RESPONSE REGULATOR receiver
SBI_RS22180	COG3104	oligopeptide transport
SBI_RS22210	COG1366	Belongs to the anti-sigma-factor antagonist family
SBI_RS22215	COG1191	sigma factor activity
SBI_RS22225	COG1228	amidohydrolase
SBI_RS22235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS22240	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SBI_RS22245	COG0604	alcohol dehydrogenase
SBI_RS22250	COG0789	Transcriptional regulator
SBI_RS22270	COG2986	histidine ammonia-lyase
SBI_RS22280	COG1174	glycine betaine transport
SBI_RS22285	COG1174	glycine betaine transport
SBI_RS22295	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS22310	COG2755	lipolytic protein G-D-S-L family
SBI_RS22315	COG0183	Belongs to the thiolase family
SBI_RS22345	COG1136	(ABC) transporter
SBI_RS22350	COG0577	efflux transmembrane transporter activity
SBI_RS22355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SBI_RS22360	COG1252	NADH dehydrogenase
SBI_RS22380	COG0148	phosphopyruvate hydratase activity
SBI_RS22390	COG1652	LysM domain
SBI_RS22395	COG2124	cytochrome p450
SBI_RS22430	COG1024	Enoyl-CoA hydratase
SBI_RS22445	COG0515	serine threonine protein kinase
SBI_RS22445	COG2815	serine threonine protein kinase
SBI_RS22510	COG1136	(ABC) transporter
SBI_RS22520	COG1376	ErfK ybiS ycfS ynhG family protein
SBI_RS22530	COG2986	histidine ammonia-lyase
SBI_RS22540	COG1024	Enoyl-CoA hydratase
SBI_RS22550	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SBI_RS22565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SBI_RS22585	COG1136	(ABC) transporter
SBI_RS22585	COG0577	efflux transmembrane transporter activity
SBI_RS22595	COG0424	maF-like protein
SBI_RS22605	COG4770	biotin carboxylase activity
SBI_RS22645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SBI_RS22650	COG4977	sequence-specific DNA binding
SBI_RS22700	COG2319	Wd-40 repeat
SBI_RS22700	COG4249	Peptidase C14 caspase catalytic subunit p20
SBI_RS22705	COG1595	DNA-templated transcription, initiation
SBI_RS22725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SBI_RS22735	COG1280	lysine exporter protein (LysE YggA)
SBI_RS22745	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS22750	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS22760	COG1595	DNA-templated transcription, initiation
SBI_RS22765	COG0745	RESPONSE REGULATOR receiver
SBI_RS22770	COG2205	protein histidine kinase activity
SBI_RS22790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SBI_RS22800	COG0583	DNA-binding transcription factor activity
SBI_RS22805	COG2814	Major facilitator Superfamily
SBI_RS22820	COG1079	Belongs to the binding-protein-dependent transport system permease family
SBI_RS22825	COG4603	Belongs to the binding-protein-dependent transport system permease family
SBI_RS22830	COG3845	ABC transporter
SBI_RS22835	COG1744	ABC transporter substrate-binding protein PnrA-like
SBI_RS22840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SBI_RS22840	COG1473	amidohydrolase
SBI_RS22850	COG2089	acid synthase
SBI_RS22865	COG1216	Glycosyl transferase, family 2
SBI_RS22875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SBI_RS22885	COG2130	NADP-dependent
SBI_RS22890	COG0583	DNA-binding transcription factor activity
SBI_RS22900	COG1733	regulation of RNA biosynthetic process
SBI_RS22930	COG0667	Aldo Keto reductase
SBI_RS22935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SBI_RS22955	COG1063	alcohol dehydrogenase
SBI_RS22960	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS22970	COG3265	gluconokinase activity
SBI_RS22975	COG2186	Transcriptional regulator
SBI_RS23040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS23040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS23055	COG1595	DNA-templated transcription, initiation
SBI_RS23065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SBI_RS23080	COG2009	succinate dehydrogenase
SBI_RS23090	COG1053	succinate dehydrogenase
SBI_RS23110	COG2409	Drug exporters of the RND superfamily
SBI_RS23115	COG0745	RESPONSE REGULATOR receiver
SBI_RS23120	COG2205	protein histidine kinase activity
SBI_RS23125	COG1408	metallophosphoesterase
SBI_RS23135	COG1686	Belongs to the peptidase S11 family
SBI_RS23140	COG1295	ribonuclease BN
SBI_RS23150	COG0180	Tryptophanyl-tRNA synthetase
SBI_RS23160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SBI_RS23185	COG0789	Transcriptional regulator
SBI_RS23195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SBI_RS23200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SBI_RS23210	COG0477	Major facilitator Superfamily
SBI_RS23215	COG0754	glutathionylspermidine amidase activity
SBI_RS23225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SBI_RS23230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS23250	COG4176	ABC-type proline glycine betaine transport system permease component
SBI_RS23255	COG0517	IMP dehydrogenase activity
SBI_RS23255	COG4175	Glycine betaine
SBI_RS23265	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS23280	COG0039	L-malate dehydrogenase activity
SBI_RS23305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SBI_RS23310	COG0138	bifunctional purine biosynthesis protein purh
SBI_RS23335	COG0045	succinate-CoA ligase (ADP-forming) activity
SBI_RS23350	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SBI_RS23360	COG0714	Associated with various cellular activities
SBI_RS23375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SBI_RS23385	COG0739	heme binding
SBI_RS23420	COG0460	homoserine dehydrogenase
SBI_RS23445	COG2910	NAD(P)H-binding
SBI_RS23450	COG2197	response regulator
SBI_RS23460	COG2815	serine threonine protein kinase
SBI_RS23460	COG0515	serine threonine protein kinase
SBI_RS23490	COG0519	Catalyzes the synthesis of GMP from XMP
SBI_RS23490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SBI_RS23500	COG0667	Aldo Keto reductase
SBI_RS23525	COG2311	Membrane
SBI_RS23535	COG0667	Aldo Keto reductase
SBI_RS23545	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS23555	COG0515	serine threonine protein kinase
SBI_RS23605	COG4585	Histidine kinase
SBI_RS23610	COG2197	response regulator
SBI_RS23630	COG2197	response regulator
SBI_RS23635	COG4585	Histidine kinase
SBI_RS23695	COG0739	heme binding
SBI_RS23695	COG1196	nuclear chromosome segregation
SBI_RS23695	COG0741	lytic transglycosylase activity
SBI_RS23820	COG4585	Histidine kinase
SBI_RS23855	COG4821	SIS domain
SBI_RS23865	COG0259	pyridoxamine-phosphate oxidase activity
SBI_RS23875	COG1309	transcriptional regulator
SBI_RS23880	COG1024	Enoyl-CoA hydratase
SBI_RS23885	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS23900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SBI_RS23960	COG0277	FAD linked oxidase domain protein
SBI_RS23960	COG0247	lactate metabolic process
SBI_RS23970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SBI_RS24005	COG0667	Aldo Keto reductase
SBI_RS24025	COG2252	PERMEase
SBI_RS24060	COG1215	transferase activity, transferring glycosyl groups
SBI_RS24080	COG2814	Major facilitator Superfamily
SBI_RS24090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SBI_RS24095	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SBI_RS24100	COG1278	Cold shock
SBI_RS24145	COG1061	Type III restriction enzyme res subunit
SBI_RS24155	COG3973	AAA domain
SBI_RS24180	COG3142	Participates in the control of copper homeostasis
SBI_RS24230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SBI_RS24235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SBI_RS24240	COG0459	protein refolding
SBI_RS24245	COG1278	Cold shock
SBI_RS24260	COG0463	Glycosyl transferase, family 2
SBI_RS24270	COG1877	trehalose-phosphatase activity
SBI_RS24270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SBI_RS24290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SBI_RS24320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SBI_RS24350	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS24360	COG4221	oxidoreductase activity
SBI_RS24410	COG1414	Transcriptional regulator
SBI_RS24430	COG3842	ATPase activity
SBI_RS24440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SBI_RS24450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SBI_RS24455	COG0215	cysteine-tRNA ligase activity
SBI_RS24460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SBI_RS24465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SBI_RS24470	COG1329	Transcriptional regulator
SBI_RS24485	COG5002	protein histidine kinase activity
SBI_RS24495	COG4585	Histidine kinase
SBI_RS24500	COG0596	Alpha beta hydrolase
SBI_RS24505	COG2197	response regulator
SBI_RS24510	COG1136	(ABC) transporter
SBI_RS24525	COG0588	phosphoglycerate mutase activity
SBI_RS24555	COG0438	transferase activity, transferring glycosyl groups
SBI_RS24565	COG0531	amino acid
SBI_RS24570	COG1940	carbohydrate kinase activity
SBI_RS24580	COG0667	Aldo Keto reductase
SBI_RS24585	COG0494	nUDIX hydrolase
SBI_RS24585	COG0406	alpha-ribazole phosphatase activity
SBI_RS24595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SBI_RS24600	COG0456	acetyltransferase
SBI_RS24600	COG0454	-acetyltransferase
SBI_RS24605	COG0737	Belongs to the 5'-nucleotidase family
SBI_RS24645	COG1335	isochorismatase
SBI_RS24710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SBI_RS24725	COG1132	(ABC) transporter
SBI_RS24745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SBI_RS24750	COG1609	Transcriptional regulator
SBI_RS24755	COG0745	RESPONSE REGULATOR receiver
SBI_RS24790	COG2897	thiosulfate sulfurtransferase activity
SBI_RS24815	COG3485	protocatechuate 3,4-dioxygenase
SBI_RS24820	COG0735	belongs to the Fur family
SBI_RS24830	COG1490	D-aminoacyl-tRNA deacylase activity
SBI_RS24840	COG4552	Acetyltransferase involved in intracellular survival and related
SBI_RS24850	COG0604	alcohol dehydrogenase
SBI_RS24890	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS24910	COG0833	amino acid
SBI_RS24920	COG1414	Transcriptional regulator
SBI_RS24925	COG0583	DNA-binding transcription factor activity
SBI_RS24930	COG0697	spore germination
SBI_RS24935	COG0702	epimerase
SBI_RS24945	COG1595	DNA-templated transcription, initiation
SBI_RS24990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SBI_RS24995	COG0306	phosphate transporter
SBI_RS25005	COG1937	Protein conserved in bacteria
SBI_RS25025	COG0671	phosphoesterase, PA-phosphatase related
SBI_RS25030	COG0739	heme binding
SBI_RS25030	COG1196	nuclear chromosome segregation
SBI_RS25030	COG0741	lytic transglycosylase activity
SBI_RS25080	COG1131	(ABC) transporter
SBI_RS25085	COG0745	RESPONSE REGULATOR receiver
SBI_RS25090	COG2205	protein histidine kinase activity
SBI_RS25145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SBI_RS25150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SBI_RS25240	COG2188	Transcriptional regulator
SBI_RS25300	COG2197	response regulator
SBI_RS25305	COG4585	Histidine kinase
SBI_RS25335	COG1609	Transcriptional regulator
SBI_RS25345	COG0395	ABC-type sugar transport system, permease component
SBI_RS25350	COG1175	transmembrane transport
SBI_RS25360	COG1621	beta-fructofuranosidase activity
SBI_RS25400	COG0515	serine threonine protein kinase
SBI_RS25400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS25410	COG0542	response to heat
SBI_RS25440	COG2197	response regulator
SBI_RS25450	COG1136	(ABC) transporter
SBI_RS25475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SBI_RS25480	COG2319	Wd-40 repeat
SBI_RS25480	COG4249	Peptidase C14 caspase catalytic subunit p20
SBI_RS25510	COG1176	ABC-type spermidine putrescine transport system, permease component I
SBI_RS25515	COG1177	transmembrane transport
SBI_RS25520	COG3842	ATPase activity
SBI_RS25525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SBI_RS25565	COG0702	epimerase
SBI_RS25585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SBI_RS25620	COG2409	Drug exporters of the RND superfamily
SBI_RS25640	COG0205	6-phosphofructokinase activity
SBI_RS25645	COG1191	sigma factor activity
SBI_RS25650	COG1191	sigma factor activity
SBI_RS25675	COG2353	YceI-like domain
SBI_RS25685	COG0477	Major facilitator Superfamily
SBI_RS25690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SBI_RS25700	COG2205	protein histidine kinase activity
SBI_RS25705	COG0745	RESPONSE REGULATOR receiver
SBI_RS25805	COG1309	transcriptional regulator
SBI_RS25810	COG2814	Major facilitator Superfamily
SBI_RS25815	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS25820	COG1595	DNA-templated transcription, initiation
SBI_RS25840	COG1960	acyl-CoA dehydrogenase activity
SBI_RS25850	COG1960	acyl-CoA dehydrogenase activity
SBI_RS25875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SBI_RS25890	COG0653	protein targeting
SBI_RS25905	COG0006	proline dipeptidase activity
SBI_RS25910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SBI_RS25930	COG1999	signal sequence binding
SBI_RS25945	COG2837	iron assimilation
SBI_RS25950	COG0077	Prephenate dehydratase
SBI_RS25955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SBI_RS25960	COG0561	phosphatase activity
SBI_RS25990	COG1131	(ABC) transporter
SBI_RS26050	COG0501	Belongs to the peptidase M48B family
SBI_RS26060	COG0561	phosphatase activity
SBI_RS26070	COG4988	ABC transporter
SBI_RS26075	COG1294	oxidase, subunit
SBI_RS26080	COG1271	oxidase subunit
SBI_RS26085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SBI_RS26090	COG1609	Transcriptional regulator
SBI_RS26135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SBI_RS26155	COG0662	Cupin 2, conserved barrel domain protein
SBI_RS26160	COG1950	PFAM Membrane protein of
SBI_RS26165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SBI_RS26170	COG0626	cystathionine gamma-synthase activity
SBI_RS26205	COG2814	Major facilitator Superfamily
SBI_RS26245	COG0242	peptide deformylase activity
SBI_RS26255	COG0305	Participates in initiation and elongation during chromosome replication
SBI_RS26260	COG0534	Mate efflux family protein
SBI_RS26265	COG0359	binds to the 23S rRNA
SBI_RS26270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SBI_RS26275	COG0629	single-stranded DNA binding
SBI_RS26280	COG0360	Binds together with S18 to 16S ribosomal RNA
SBI_RS26305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SBI_RS26315	COG1260	myo-inositol-1-phosphate synthase
SBI_RS26325	COG0617	tRNA 3'-terminal CCA addition
SBI_RS26340	COG2815	serine threonine protein kinase
SBI_RS26340	COG0515	serine threonine protein kinase
SBI_RS26345	COG1595	DNA-templated transcription, initiation
SBI_RS26355	COG0492	ferredoxin-NADP+ reductase activity
SBI_RS26360	COG3118	belongs to the thioredoxin family
SBI_RS26375	COG1192	Involved in chromosome partitioning
SBI_RS26380	COG0357	Ribosomal RNA small subunit methyltransferase G
SBI_RS26390	COG0706	membrane insertase activity
SBI_RS26395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SBI_RS26400	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SBI_RS26410	COG0592	DNA-directed DNA polymerase activity
SBI_RS26415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SBI_RS26420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SBI_RS26425	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SBI_RS26435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SBI_RS26455	COG0515	serine threonine protein kinase
SBI_RS26485	COG0705	Rhomboid family
SBI_RS26500	COG3764	Sortase (surface protein transpeptidase)
SBI_RS26515	COG3764	Sortase (surface protein transpeptidase)
SBI_RS26520	COG3764	Sortase (surface protein transpeptidase)
SBI_RS26525	COG0515	serine threonine protein kinase
SBI_RS26530	COG0768	penicillin binding
SBI_RS26545	COG1716	ATPase activity
SBI_RS26550	COG1716	ATPase activity
SBI_RS26560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SBI_RS26565	COG1733	regulation of RNA biosynthetic process
SBI_RS26590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SBI_RS26595	COG2151	metal-sulfur cluster biosynthetic enzyme
SBI_RS26600	COG3396	Phenylacetate-CoA oxygenase
SBI_RS26605	COG3460	Phenylacetate-CoA oxygenase
SBI_RS26610	COG3396	Phenylacetate-CoA oxygenase
SBI_RS26635	COG1250	3-hydroxyacyl-CoA dehydrogenase
SBI_RS26640	COG1309	transcriptional regulator
SBI_RS26645	COG1522	sequence-specific DNA binding
SBI_RS26665	COG0746	molybdenum cofactor guanylyltransferase activity
SBI_RS26675	COG0604	alcohol dehydrogenase
SBI_RS26675	COG3321	synthase
SBI_RS26675	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS26695	COG0515	serine threonine protein kinase
SBI_RS26700	COG0515	serine threonine protein kinase
SBI_RS26720	COG0022	dehydrogenase e1 component
SBI_RS26725	COG0508	dehydrogenase complex catalyzes the overall conversion of
SBI_RS26770	COG1733	regulation of RNA biosynthetic process
SBI_RS26810	COG3903	Transcriptional regulator
SBI_RS26810	COG3629	intracellular signal transduction
SBI_RS26815	COG1362	aminopeptidase activity
SBI_RS26830	COG1960	acyl-CoA dehydrogenase activity
SBI_RS26840	COG1741	Belongs to the pirin family
SBI_RS26865	COG2837	iron assimilation
SBI_RS26875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SBI_RS26900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SBI_RS26905	COG2304	oxidoreductase activity
SBI_RS26935	COG1793	dna ligase
SBI_RS26950	COG3290	protein histidine kinase activity
SBI_RS26980	COG2124	cytochrome p450
SBI_RS27025	COG0667	Aldo Keto reductase
SBI_RS27085	COG0577	efflux transmembrane transporter activity
SBI_RS27085	COG1136	(ABC) transporter
SBI_RS27090	COG4585	Histidine kinase
SBI_RS27095	COG2197	response regulator
SBI_RS27100	COG0248	Ppx GppA phosphatase
SBI_RS27105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SBI_RS27125	COG0367	asparagine synthase
SBI_RS27135	COG4977	sequence-specific DNA binding
SBI_RS27140	COG0531	amino acid
SBI_RS27165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SBI_RS27165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SBI_RS27175	COG0183	Belongs to the thiolase family
SBI_RS27185	COG2268	Band 7 protein
SBI_RS27210	COG2211	Major facilitator Superfamily
SBI_RS27275	COG0535	radical SAM domain protein
SBI_RS27285	COG2205	protein histidine kinase activity
SBI_RS27290	COG0745	RESPONSE REGULATOR receiver
SBI_RS27305	COG1136	(ABC) transporter
SBI_RS27305	COG0577	efflux transmembrane transporter activity
SBI_RS27310	COG0577	efflux transmembrane transporter activity
SBI_RS27325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS27350	COG4585	Histidine kinase
SBI_RS27355	COG2197	response regulator
SBI_RS27370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SBI_RS27375	COG1395	domain, Protein
SBI_RS27405	COG4585	Histidine kinase
SBI_RS27410	COG1136	(ABC) transporter
SBI_RS27410	COG0577	efflux transmembrane transporter activity
SBI_RS27420	COG0515	serine threonine protein kinase
SBI_RS27420	COG2815	serine threonine protein kinase
SBI_RS27470	COG0515	serine threonine protein kinase
SBI_RS27470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS27480	COG0583	DNA-binding transcription factor activity
SBI_RS27525	COG3903	Transcriptional regulator
SBI_RS27525	COG3629	intracellular signal transduction
SBI_RS27530	COG0726	polysaccharide deacetylase
SBI_RS27635	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SBI_RS27640	COG1396	sequence-specific DNA binding
SBI_RS27670	COG0717	Belongs to the dCTP deaminase family
SBI_RS27675	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SBI_RS27690	COG3290	protein histidine kinase activity
SBI_RS27695	COG2181	nitrate reductase activity
SBI_RS27695	COG0247	lactate metabolic process
SBI_RS27700	COG0443	Heat shock 70 kDa protein
SBI_RS27705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SBI_RS27710	COG0484	heat shock protein binding
SBI_RS27715	COG0789	Transcriptional regulator
SBI_RS27755	COG1595	DNA-templated transcription, initiation
SBI_RS27760	COG4941	Belongs to the sigma-70 factor family
SBI_RS27785	COG0542	response to heat
SBI_RS27810	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SBI_RS27825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SBI_RS27830	COG0191	fructose-bisphosphate aldolase activity
SBI_RS27835	COG0477	Major facilitator Superfamily
SBI_RS27845	COG3483	tryptophan 2,3-dioxygenase activity
SBI_RS27850	COG3844	kynureninase activity
SBI_RS27860	COG2124	cytochrome p450
SBI_RS27865	COG3559	Exporter of polyketide antibiotics
SBI_RS27870	COG1131	(ABC) transporter
SBI_RS27885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SBI_RS27890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS27890	COG0515	serine threonine protein kinase
SBI_RS27900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SBI_RS27905	COG1802	Transcriptional regulator
SBI_RS27910	COG0463	Glycosyl transferase, family 2
SBI_RS27965	COG2318	DinB family
SBI_RS27970	COG0789	Transcriptional regulator
SBI_RS28005	COG0151	Belongs to the GarS family
SBI_RS28020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SBI_RS28040	COG2197	response regulator
SBI_RS28055	COG1131	(ABC) transporter
SBI_RS28080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SBI_RS28085	COG0047	phosphoribosylformylglycinamidine synthase activity
SBI_RS28090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SBI_RS28110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SBI_RS28120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SBI_RS28140	COG1643	Atp-dependent helicase
SBI_RS28150	COG1970	mechanosensitive ion channel activity
SBI_RS28180	COG0513	Belongs to the DEAD box helicase family
SBI_RS28230	COG0667	Aldo Keto reductase
SBI_RS28340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SBI_RS28345	COG0579	oxidoreductase
SBI_RS28370	COG1252	NADH dehydrogenase
SBI_RS28405	COG4191	Histidine kinase
SBI_RS28510	COG1408	metallophosphoesterase
SBI_RS28520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SBI_RS28530	COG0003	Pfam Anion-transporting ATPase
SBI_RS28570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SBI_RS28595	COG2267	carboxylic ester hydrolase activity
SBI_RS28605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SBI_RS28610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS28675	COG1725	Transcriptional regulator
SBI_RS28690	COG0494	nUDIX hydrolase
SBI_RS28730	COG1111	helicase
SBI_RS28730	COG1205	dead DEAH box helicase
SBI_RS28735	COG1366	Belongs to the anti-sigma-factor antagonist family
SBI_RS28740	COG2172	sigma factor antagonist activity
SBI_RS28745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SBI_RS28755	COG2890	protein-(glutamine-N5) methyltransferase activity
SBI_RS28765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SBI_RS28765	COG1754	DNA topoisomerase type I activity
SBI_RS28770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SBI_RS28775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SBI_RS28780	COG0596	Alpha beta hydrolase
SBI_RS28820	COG1120	ATPase activity
SBI_RS28825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS28830	COG5398	heme oxygenase
SBI_RS28845	COG0142	geranyltranstransferase activity
SBI_RS28855	COG2197	response regulator
SBI_RS28860	COG2197	response regulator
SBI_RS28865	COG2197	response regulator
SBI_RS28910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SBI_RS28920	COG1595	DNA-templated transcription, initiation
SBI_RS28935	COG1077	Cell shape determining protein MreB Mrl
SBI_RS28945	COG3940	Belongs to the glycosyl hydrolase 43 family
SBI_RS28970	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS28975	COG2318	DinB family
SBI_RS28985	COG1136	(ABC) transporter
SBI_RS28990	COG4585	Histidine kinase
SBI_RS28995	COG2204	response regulator
SBI_RS29020	COG0076	glutamate decarboxylase activity
SBI_RS29030	COG0789	Transcriptional regulator
SBI_RS29035	COG0586	Pfam SNARE associated Golgi protein
SBI_RS29045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SBI_RS29050	COG2027	D-alanyl-D-alanine carboxypeptidase
SBI_RS29060	COG0037	tRNA processing
SBI_RS29075	COG0302	gtp cyclohydrolase
SBI_RS29085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SBI_RS29090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SBI_RS29105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SBI_RS29105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SBI_RS29115	COG0517	IMP dehydrogenase activity
SBI_RS29115	COG1125	glycine betaine transport
SBI_RS29125	COG1174	glycine betaine transport
SBI_RS29140	COG0649	NAD binding
SBI_RS29155	COG2197	response regulator
SBI_RS29160	COG0640	Transcriptional regulator
SBI_RS29180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SBI_RS29185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SBI_RS29195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SBI_RS29225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SBI_RS29305	COG0667	Aldo Keto reductase
SBI_RS29310	COG0456	acetyltransferase
SBI_RS29310	COG1846	Transcriptional regulator
SBI_RS29320	COG0739	heme binding
SBI_RS29335	COG2205	protein histidine kinase activity
SBI_RS29340	COG0745	RESPONSE REGULATOR receiver
SBI_RS29350	COG1595	DNA-templated transcription, initiation
SBI_RS29355	COG1194	a g-specific adenine glycosylase
SBI_RS29370	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SBI_RS29390	COG0248	Ppx GppA phosphatase
SBI_RS29395	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS29405	COG0129	dihydroxy-acid dehydratase activity
SBI_RS29410	COG0515	serine threonine protein kinase
SBI_RS29410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS29420	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS29420	COG0515	serine threonine protein kinase
SBI_RS29440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SBI_RS29445	COG0180	Tryptophanyl-tRNA synthetase
SBI_RS29465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SBI_RS29475	COG0123	including yeast histone deacetylase and acetoin utilization protein
SBI_RS29520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SBI_RS29525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SBI_RS29530	COG0181	hydroxymethylbilane synthase activity
SBI_RS29535	COG1648	precorrin-2 dehydrogenase activity
SBI_RS29535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SBI_RS29540	COG0113	porphobilinogen synthase activity
SBI_RS29545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SBI_RS29595	COG0018	arginyl-trna synthetase
SBI_RS29600	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SBI_RS29620	COG1690	Belongs to the RtcB family
SBI_RS29640	COG1742	UPF0060 membrane protein
SBI_RS29720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS29735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS29755	COG1181	Belongs to the D-alanine--D-alanine ligase family
SBI_RS29760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS29765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SBI_RS29780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SBI_RS29785	COG0406	alpha-ribazole phosphatase activity
SBI_RS29795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SBI_RS29805	COG1333	cytochrome c biogenesis protein
SBI_RS29810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SBI_RS29830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SBI_RS29835	COG0109	protoheme IX farnesyltransferase activity
SBI_RS29840	COG0163	prenyltransferase activity
SBI_RS29850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SBI_RS29860	COG1301	dicarboxylic acid transport
SBI_RS29870	COG0492	ferredoxin-NADP+ reductase activity
SBI_RS29880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SBI_RS29910	COG1278	Cold shock
SBI_RS29915	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SBI_RS29925	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SBI_RS29935	COG2226	methyltransferase
SBI_RS29965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS29970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS29975	COG0649	NAD binding
SBI_RS29985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SBI_RS29990	COG1034	ATP synthesis coupled electron transport
SBI_RS29995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SBI_RS30000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS30005	COG0839	Belongs to the complex I subunit 6 family
SBI_RS30010	COG0713	ATP synthesis coupled electron transport
SBI_RS30015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SBI_RS30025	COG1007	ATP synthesis coupled electron transport
SBI_RS30045	COG0492	ferredoxin-NADP+ reductase activity
SBI_RS30050	COG0142	geranyltranstransferase activity
SBI_RS30080	COG0702	epimerase
SBI_RS30085	COG1733	regulation of RNA biosynthetic process
SBI_RS30090	COG1013	pyruvate-flavodoxin oxidoreductase activity
SBI_RS30095	COG0674	pyruvate-flavodoxin oxidoreductase activity
SBI_RS30095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SBI_RS30115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS30120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS30125	COG0649	NAD binding
SBI_RS30125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS30130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SBI_RS30135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SBI_RS30140	COG0839	Belongs to the complex I subunit 6 family
SBI_RS30145	COG0713	ATP synthesis coupled electron transport
SBI_RS30150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SBI_RS30160	COG1007	ATP synthesis coupled electron transport
SBI_RS30165	COG0501	Belongs to the peptidase M48B family
SBI_RS30170	COG3304	Inner membrane component domain
SBI_RS30175	COG1666	GTP binding
SBI_RS30195	COG2124	cytochrome p450
SBI_RS30205	COG0702	epimerase
SBI_RS30230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SBI_RS30235	COG2030	dehydratase
SBI_RS30245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SBI_RS30255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SBI_RS30260	COG0436	Aminotransferase
SBI_RS30275	COG0250	Participates in transcription elongation, termination and antitermination
SBI_RS30280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SBI_RS30285	COG0081	regulation of translation
SBI_RS30295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SBI_RS30300	COG0222	ribosome binding
SBI_RS30305	COG0085	RNA polymerase activity
SBI_RS30310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SBI_RS30315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SBI_RS30320	COG0049	tRNA binding
SBI_RS30325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SBI_RS30330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SBI_RS30340	COG0515	serine threonine protein kinase
SBI_RS30340	COG2815	serine threonine protein kinase
SBI_RS30380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SBI_RS30385	COG1846	Transcriptional regulator
SBI_RS30395	COG1309	transcriptional regulator
SBI_RS30400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SBI_RS30415	COG0051	transcription antitermination factor activity, RNA binding
SBI_RS30420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SBI_RS30425	COG0088	Forms part of the polypeptide exit tunnel
SBI_RS30430	COG0089	rRNA binding
SBI_RS30435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SBI_RS30440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SBI_RS30445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SBI_RS30450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SBI_RS30455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SBI_RS30460	COG0255	Belongs to the universal ribosomal protein uL29 family
SBI_RS30465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SBI_RS30470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SBI_RS30475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SBI_RS30480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SBI_RS30485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SBI_RS30490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SBI_RS30495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SBI_RS30500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SBI_RS30505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SBI_RS30515	COG0200	Binds to the 23S rRNA
SBI_RS30525	COG0563	adenylate kinase activity
SBI_RS30535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SBI_RS30540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SBI_RS30545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SBI_RS30550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SBI_RS30555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SBI_RS30560	COG0202	RNA polymerase activity
SBI_RS30565	COG0203	ribosomal protein L17
SBI_RS30570	COG0101	tRNA pseudouridine synthase activity
SBI_RS30575	COG0438	transferase activity, transferring glycosyl groups
SBI_RS30580	COG0702	epimerase
SBI_RS30595	COG0488	(ABC) transporter
SBI_RS30600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SBI_RS30605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SBI_RS30610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SBI_RS30620	COG1072	(Pantothenic acid kinase))
SBI_RS30630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SBI_RS30635	COG0736	holo-[acyl-carrier-protein] synthase activity
SBI_RS30665	COG2409	Drug exporters of the RND superfamily
SBI_RS30670	COG4585	Histidine kinase
SBI_RS30675	COG2197	response regulator
SBI_RS30690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SBI_RS30700	COG0802	atpase or kinase
SBI_RS30715	COG0456	acetyltransferase
SBI_RS30715	COG1214	PFAM Peptidase M22, glycoprotease
SBI_RS30725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SBI_RS30775	COG0726	polysaccharide deacetylase
SBI_RS30780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SBI_RS30790	COG4221	oxidoreductase activity
SBI_RS30800	COG0583	DNA-binding transcription factor activity
SBI_RS30815	COG1595	DNA-templated transcription, initiation
SBI_RS30825	COG0516	GMP reductase activity
SBI_RS30835	COG1077	Cell shape determining protein MreB Mrl
SBI_RS30850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SBI_RS30870	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS30875	COG1960	acyl-CoA dehydrogenase activity
SBI_RS30880	COG1960	acyl-CoA dehydrogenase activity
SBI_RS30895	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS30900	COG1960	acyl-CoA dehydrogenase activity
SBI_RS30905	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS30930	COG1024	Enoyl-CoA hydratase
SBI_RS30940	COG2072	flavoprotein involved in K transport
SBI_RS30960	COG0259	pyridoxamine-phosphate oxidase activity
SBI_RS30970	COG1960	acyl-CoA dehydrogenase activity
SBI_RS30980	COG1309	transcriptional regulator
SBI_RS30990	COG0515	serine threonine protein kinase
SBI_RS30990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS31005	COG1024	Enoyl-CoA hydratase
SBI_RS31055	COG0596	Alpha beta hydrolase
SBI_RS31060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS31065	COG1309	transcriptional regulator
SBI_RS31095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS31115	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS31130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SBI_RS31135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SBI_RS31135	COG0519	Catalyzes the synthesis of GMP from XMP
SBI_RS31180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SBI_RS31205	COG1686	Belongs to the peptidase S11 family
SBI_RS31215	COG1653	transport
SBI_RS31255	COG0702	epimerase
SBI_RS31260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SBI_RS31265	COG1793	dna ligase
SBI_RS31265	COG3285	dna ligase
SBI_RS31270	COG1793	dna ligase
SBI_RS31275	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SBI_RS31290	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SBI_RS31315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SBI_RS31330	COG1846	Transcriptional regulator
SBI_RS31350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS31360	COG2207	Transcriptional regulator
SBI_RS31360	COG3708	Transcriptional regulator
SBI_RS31385	COG1309	transcriptional regulator
SBI_RS31390	COG3631	Ketosteroid isomerase-related protein
SBI_RS31395	COG4977	sequence-specific DNA binding
SBI_RS31480	COG3629	intracellular signal transduction
SBI_RS31480	COG3903	Transcriptional regulator
SBI_RS31510	COG0667	Aldo Keto reductase
SBI_RS31580	COG0395	ABC-type sugar transport system, permease component
SBI_RS31600	COG1609	Transcriptional regulator
SBI_RS31610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SBI_RS31615	COG1104	cysteine desulfurase activity
SBI_RS31640	COG0137	argininosuccinate synthase activity
SBI_RS31645	COG1181	Belongs to the D-alanine--D-alanine ligase family
SBI_RS31665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS31725	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SBI_RS31730	COG0076	glutamate decarboxylase activity
SBI_RS31765	COG1309	transcriptional regulator
SBI_RS31785	COG1846	Transcriptional regulator
SBI_RS31790	COG3384	dioxygenase
SBI_RS31810	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS31815	COG1349	DNA-binding transcription factor activity
SBI_RS31820	COG1105	Belongs to the carbohydrate kinase PfkB family
SBI_RS31830	COG3634	alkyl hydroperoxide reductase activity
SBI_RS31840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SBI_RS31850	COG1970	mechanosensitive ion channel activity
SBI_RS31860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SBI_RS31870	COG3263	regulation of cellular component size
SBI_RS31880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SBI_RS31885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SBI_RS31895	COG0315	cyclic pyranopterin monophosphate synthase activity
SBI_RS31900	COG0521	Mo-molybdopterin cofactor biosynthetic process
SBI_RS31925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SBI_RS31930	COG0745	RESPONSE REGULATOR receiver
SBI_RS31935	COG5002	protein histidine kinase activity
SBI_RS31940	COG0823	Involved in the tonB-independent uptake of proteins
SBI_RS31950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SBI_RS31955	COG2197	response regulator
SBI_RS31960	COG3214	Protein conserved in bacteria
SBI_RS31970	COG0653	protein targeting
SBI_RS31990	COG0693	protein deglycase activity
SBI_RS31995	COG2902	Dehydrogenase
SBI_RS32000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SBI_RS32050	COG0438	transferase activity, transferring glycosyl groups
SBI_RS32055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SBI_RS32060	COG0395	ABC-type sugar transport system, permease component
SBI_RS32065	COG1175	transmembrane transport
SBI_RS32070	COG1653	transport
SBI_RS32080	COG0515	serine threonine protein kinase
SBI_RS32085	COG0515	serine threonine protein kinase
SBI_RS32090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SBI_RS32105	COG2884	Cell division ATP-binding protein ftsE
SBI_RS32110	COG2177	Part of the ABC transporter FtsEX involved in
SBI_RS32115	COG0793	Belongs to the peptidase S41A family
SBI_RS32120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SBI_RS32130	COG2910	NAD(P)H-binding
SBI_RS32175	COG1595	DNA-templated transcription, initiation
SBI_RS32190	COG1609	Transcriptional regulator
SBI_RS32195	COG0395	ABC-type sugar transport system, permease component
SBI_RS32220	COG0583	DNA-binding transcription factor activity
SBI_RS32225	COG2223	nitrite transmembrane transporter activity
SBI_RS32250	COG3973	AAA domain
SBI_RS32260	COG0776	regulation of translation
SBI_RS32265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SBI_RS32270	COG1678	Uncharacterized ACR, COG1678
SBI_RS32290	COG1175	transmembrane transport
SBI_RS32295	COG0395	ABC-type sugar transport system, permease component
SBI_RS32300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SBI_RS32320	COG0745	RESPONSE REGULATOR receiver
SBI_RS32325	COG2205	protein histidine kinase activity
SBI_RS32330	COG0577	efflux transmembrane transporter activity
SBI_RS32335	COG1136	(ABC) transporter
SBI_RS32375	COG1595	DNA-templated transcription, initiation
SBI_RS32385	COG1595	DNA-templated transcription, initiation
SBI_RS32390	COG1252	NADH dehydrogenase
SBI_RS32405	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS32440	COG1609	Transcriptional regulator
SBI_RS32450	COG1175	transmembrane transport
SBI_RS32455	COG0395	ABC-type sugar transport system, permease component
SBI_RS32650	COG2855	membrane
SBI_RS32670	COG3654	unkown
SBI_RS32705	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SBI_RS32715	COG0277	FAD linked oxidase domain protein
SBI_RS32720	COG0596	Alpha beta hydrolase
SBI_RS32765	COG1064	alcohol dehydrogenase
SBI_RS32805	COG1335	isochorismatase
SBI_RS32815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SBI_RS32825	COG1113	amino acid transport
SBI_RS32845	COG1234	tRNA 3'-trailer cleavage
SBI_RS32850	COG1263	PTS System
SBI_RS32855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SBI_RS32860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SBI_RS32870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SBI_RS32885	COG2318	DinB family
SBI_RS32905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SBI_RS32940	COG2733	membrane
SBI_RS32945	COG3764	Sortase (surface protein transpeptidase)
SBI_RS32955	COG0706	membrane insertase activity
SBI_RS32965	COG0673	inositol 2-dehydrogenase activity
SBI_RS33010	COG2186	Transcriptional regulator
SBI_RS33020	COG3397	chitin binding
SBI_RS33055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS33060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SBI_RS33075	COG1063	alcohol dehydrogenase
SBI_RS33105	COG0640	Transcriptional regulator
SBI_RS33110	COG0604	alcohol dehydrogenase
SBI_RS33110	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS33110	COG3321	synthase
SBI_RS33120	COG0477	Major facilitator Superfamily
SBI_RS33130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS33145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS33165	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS33195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS33200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS33205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SBI_RS33210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SBI_RS33215	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS33230	COG4770	biotin carboxylase activity
SBI_RS33250	COG1131	(ABC) transporter
SBI_RS33255	COG4585	Histidine kinase
SBI_RS33260	COG2197	response regulator
SBI_RS33265	COG2197	response regulator
SBI_RS33320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS33325	COG1595	DNA-templated transcription, initiation
SBI_RS33330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SBI_RS33380	COG0596	Alpha beta hydrolase
SBI_RS33390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SBI_RS33400	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS33410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS33425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS33430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS33435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SBI_RS33475	COG1131	(ABC) transporter
SBI_RS33485	COG4585	Histidine kinase
SBI_RS33490	COG2197	response regulator
SBI_RS33505	COG4565	transcriptional regulatory protein
SBI_RS33510	COG3290	protein histidine kinase activity
SBI_RS33520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS33545	COG1126	abc transporter atp-binding protein
SBI_RS33550	COG0765	amino acid transport
SBI_RS33555	COG0765	amino acid transport
SBI_RS33560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SBI_RS33570	COG0154	amidase activity
SBI_RS33590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS33610	COG1131	(ABC) transporter
SBI_RS33625	COG2197	response regulator
SBI_RS33645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SBI_RS33655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SBI_RS33675	COG2249	NAD(P)H dehydrogenase (quinone) activity
SBI_RS33695	COG2867	negative regulation of translational initiation
SBI_RS33700	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS33705	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS33735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS33740	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS33775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SBI_RS33795	COG1819	glycosyl
SBI_RS33860	COG1595	DNA-templated transcription, initiation
SBI_RS33865	COG0655	NAD(P)H dehydrogenase (quinone) activity
SBI_RS33880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SBI_RS33920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SBI_RS33930	COG5297	Belongs to the glycosyl hydrolase family 6
SBI_RS33940	COG4733	cellulase activity
SBI_RS33940	COG5297	Belongs to the glycosyl hydrolase family 6
SBI_RS33945	COG1215	transferase activity, transferring glycosyl groups
SBI_RS33990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SBI_RS33995	COG4977	sequence-specific DNA binding
SBI_RS34005	COG0589	response to stress
SBI_RS34010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SBI_RS34035	COG1960	acyl-CoA dehydrogenase activity
SBI_RS34050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SBI_RS34055	COG1309	transcriptional regulator
SBI_RS34065	COG1946	Acyl-CoA thioesterase
SBI_RS34080	COG1278	Cold shock
SBI_RS34135	COG1473	amidohydrolase
SBI_RS34140	COG0697	spore germination
SBI_RS34185	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS34200	COG0697	spore germination
SBI_RS34210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SBI_RS34225	COG1609	Transcriptional regulator
SBI_RS34245	COG1653	transport
SBI_RS34250	COG1175	transmembrane transport
SBI_RS34255	COG0395	ABC-type sugar transport system, permease component
SBI_RS34270	COG0673	inositol 2-dehydrogenase activity
SBI_RS34290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SBI_RS34320	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS34330	COG0789	Transcriptional regulator
SBI_RS34335	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS34340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SBI_RS34345	COG4221	oxidoreductase activity
SBI_RS34385	COG0640	Transcriptional regulator
SBI_RS34410	COG1869	D-ribose catabolic process
SBI_RS34415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS34425	COG1129	ABC transporter
SBI_RS34435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SBI_RS34460	COG2409	Drug exporters of the RND superfamily
SBI_RS34465	COG0395	ABC-type sugar transport system, permease component
SBI_RS34470	COG1175	transmembrane transport
SBI_RS34485	COG1349	DNA-binding transcription factor activity
SBI_RS34490	COG1486	melibiose metabolic process
SBI_RS34500	COG0673	inositol 2-dehydrogenase activity
SBI_RS34525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS34535	COG3718	enzyme involved in inositol metabolism
SBI_RS34540	COG3962	Belongs to the TPP enzyme family
SBI_RS34595	COG3226	Transcriptional regulator
SBI_RS34615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SBI_RS34620	COG1053	succinate dehydrogenase
SBI_RS34630	COG0583	DNA-binding transcription factor activity
SBI_RS34635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SBI_RS34640	COG1993	acr, cog1993
SBI_RS34645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SBI_RS34660	COG1846	Transcriptional regulator
SBI_RS34670	COG2409	Drug exporters of the RND superfamily
SBI_RS34690	COG0629	single-stranded DNA binding
SBI_RS34715	COG2346	COG2346, Truncated hemoglobins
SBI_RS34720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SBI_RS34755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SBI_RS34770	COG1486	melibiose metabolic process
SBI_RS34775	COG0395	ABC-type sugar transport system, permease component
SBI_RS34780	COG1175	transmembrane transport
SBI_RS34785	COG1653	transport
SBI_RS34790	COG1940	carbohydrate kinase activity
SBI_RS34790	COG1846	Transcriptional regulator
SBI_RS34805	COG0668	transmembrane transport
SBI_RS34815	COG3291	Pkd domain containing protein
SBI_RS34815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SBI_RS34865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SBI_RS34870	COG1113	amino acid transport
SBI_RS34880	COG1113	amino acid transport
SBI_RS34885	COG0698	ribose 5-phosphate isomerase
SBI_RS34895	COG4552	Acetyltransferase involved in intracellular survival and related
SBI_RS34905	COG1136	(ABC) transporter
SBI_RS34915	COG3594	Acyltransferase
SBI_RS34935	COG0544	peptidyl-prolyl cis-trans isomerase activity
SBI_RS34940	COG0740	serine-type endopeptidase activity
SBI_RS34945	COG0740	serine-type endopeptidase activity
SBI_RS34950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SBI_RS34980	COG0525	valine-tRNA ligase activity
SBI_RS34985	COG0285	dihydrofolate synthase activity
SBI_RS34995	COG0105	UTP biosynthetic process
SBI_RS35000	COG1077	Cell shape determining protein MreB Mrl
SBI_RS35020	COG0772	Belongs to the SEDS family
SBI_RS35040	COG1530	ribonuclease E activity
SBI_RS35045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SBI_RS35050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SBI_RS35055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SBI_RS35075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SBI_RS35090	COG0501	Belongs to the peptidase M48B family
SBI_RS35105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SBI_RS35115	COG0799	negative regulation of ribosome biogenesis
SBI_RS35120	COG0588	phosphoglycerate mutase activity
SBI_RS35135	COG0477	Major facilitator Superfamily
SBI_RS35150	COG0495	leucyl-tRNA aminoacylation
SBI_RS35160	COG1307	EDD domain protein, DegV family
SBI_RS35165	COG1555	photosystem II stabilization
SBI_RS35165	COG1596	polysaccharide export
SBI_RS35190	COG0268	Binds directly to 16S ribosomal RNA
SBI_RS35195	COG0481	GTPase activity
SBI_RS35200	COG1022	Amp-dependent synthetase and ligase
SBI_RS35225	COG1420	regulation of RNA biosynthetic process
SBI_RS35230	COG0484	heat shock protein binding
SBI_RS35250	COG0537	adenosine 5'-monophosphoramidase activity
SBI_RS35255	COG1234	tRNA 3'-trailer cleavage
SBI_RS35270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SBI_RS35285	COG0667	Aldo Keto reductase
SBI_RS35290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SBI_RS35305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SBI_RS35315	COG2409	Drug exporters of the RND superfamily
SBI_RS35320	COG4585	Histidine kinase
SBI_RS35325	COG2197	response regulator
SBI_RS35375	COG1960	acyl-CoA dehydrogenase activity
SBI_RS35400	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS35405	COG0477	Major facilitator Superfamily
SBI_RS35410	COG2124	cytochrome p450
SBI_RS35455	COG1309	transcriptional regulator
SBI_RS35460	COG0702	epimerase
SBI_RS35470	COG0596	Alpha beta hydrolase
SBI_RS35485	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS35500	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SBI_RS35505	COG1476	TRANSCRIPTIONal
SBI_RS35580	COG1381	Involved in DNA repair and RecF pathway recombination
SBI_RS35585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SBI_RS35605	COG2197	response regulator
SBI_RS35615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SBI_RS35620	COG1121	(ABC) transporter
SBI_RS35630	COG0423	glycine-tRNA ligase activity
SBI_RS35650	COG2197	response regulator
SBI_RS35660	COG2226	methyltransferase
SBI_RS35685	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SBI_RS35690	COG0574	Belongs to the PEP-utilizing enzyme family
SBI_RS35690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SBI_RS35720	COG1733	regulation of RNA biosynthetic process
SBI_RS35745	COG0395	ABC-type sugar transport system, permease component
SBI_RS35755	COG2182	Extracellular solute-binding protein
SBI_RS35760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SBI_RS35765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SBI_RS35770	COG3485	protocatechuate 3,4-dioxygenase
SBI_RS35775	COG3485	protocatechuate 3,4-dioxygenase
SBI_RS35780	COG0183	Belongs to the thiolase family
SBI_RS35785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SBI_RS35790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SBI_RS35795	COG1846	Transcriptional regulator
SBI_RS35800	COG1414	Transcriptional regulator
SBI_RS35810	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS35810	COG0604	alcohol dehydrogenase
SBI_RS35810	COG3321	synthase
SBI_RS35820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SBI_RS35905	COG3896	Chloramphenicol phosphotransferase-like protein
SBI_RS35920	COG0596	Alpha beta hydrolase
SBI_RS35950	COG1175	transmembrane transport
SBI_RS35960	COG1609	Transcriptional regulator
SBI_RS36025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SBI_RS36025	COG2146	nitrite reductase [NAD(P)H] activity
SBI_RS36030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SBI_RS36040	COG2124	cytochrome p450
SBI_RS36065	COG2205	protein histidine kinase activity
SBI_RS36070	COG0745	RESPONSE REGULATOR receiver
SBI_RS36085	COG0438	transferase activity, transferring glycosyl groups
SBI_RS36100	COG0384	phenazine biosynthesis protein PhzF
SBI_RS36130	COG1609	Transcriptional regulator
SBI_RS36140	COG1175	transmembrane transport
SBI_RS36165	COG2949	membrane
SBI_RS36170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SBI_RS36180	COG0243	molybdopterin cofactor binding
SBI_RS36190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SBI_RS36200	COG0358	DNA primase activity
SBI_RS36205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SBI_RS36210	COG1070	Carbohydrate kinase
SBI_RS36235	COG1595	DNA-templated transcription, initiation
SBI_RS36265	COG2409	Drug exporters of the RND superfamily
SBI_RS36280	COG1609	Transcriptional regulator
SBI_RS36285	COG2814	Major facilitator Superfamily
SBI_RS36315	COG2205	protein histidine kinase activity
SBI_RS36320	COG0745	RESPONSE REGULATOR receiver
SBI_RS36360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SBI_RS36365	COG0588	phosphoglycerate mutase activity
SBI_RS36380	COG1414	Transcriptional regulator
SBI_RS36400	COG2130	NADP-dependent
SBI_RS36415	COG1175	transmembrane transport
SBI_RS36420	COG0395	ABC-type sugar transport system, permease component
SBI_RS36425	COG5520	Belongs to the glycosyl hydrolase 30 family
SBI_RS36430	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS36450	COG2318	DinB family
SBI_RS36460	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SBI_RS36495	COG2610	gluconate transmembrane transporter activity
SBI_RS36500	COG2084	Dehydrogenase
SBI_RS36515	COG1802	Transcriptional regulator
SBI_RS36570	COG4214	carbohydrate transport
SBI_RS36575	COG1129	ABC transporter
SBI_RS36590	COG1063	alcohol dehydrogenase
SBI_RS36640	COG1309	transcriptional regulator
SBI_RS36670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS36675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS36700	COG0789	Transcriptional regulator
SBI_RS36710	COG0675	Transposase, IS605 OrfB family
SBI_RS36715	COG4585	Histidine kinase
SBI_RS36720	COG2197	response regulator
SBI_RS36750	COG1309	transcriptional regulator
SBI_RS36755	COG0477	Major facilitator Superfamily
SBI_RS36760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SBI_RS36805	COG1358	cellular component organization or biogenesis
SBI_RS36815	COG0586	Pfam SNARE associated Golgi protein
SBI_RS36820	COG4585	Histidine kinase
SBI_RS36825	COG2201	protein-glutamate methylesterase activity
SBI_RS36860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SBI_RS36895	COG3547	Transposase (IS116 IS110 IS902 family)
SBI_RS36920	COG0251	oxidation-reduction process
SBI_RS37050	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS37055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SBI_RS37070	COG0667	Aldo Keto reductase
SBI_RS37075	COG0243	molybdopterin cofactor binding
SBI_RS37080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SBI_RS37120	COG2318	DinB family
SBI_RS37130	COG0515	serine threonine protein kinase
SBI_RS37130	COG2815	serine threonine protein kinase
SBI_RS37155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS37190	COG2124	cytochrome p450
SBI_RS37195	COG0183	Belongs to the thiolase family
SBI_RS37220	COG3845	ABC transporter
SBI_RS37245	COG1309	transcriptional regulator
SBI_RS37265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS37370	COG1132	(ABC) transporter
SBI_RS37375	COG1132	(ABC) transporter
SBI_RS37380	COG1309	transcriptional regulator
SBI_RS37385	COG0438	transferase activity, transferring glycosyl groups
SBI_RS37400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS37410	COG0860	N-Acetylmuramoyl-L-alanine amidase
SBI_RS37430	COG2130	NADP-dependent
SBI_RS37440	COG1960	acyl-CoA dehydrogenase activity
SBI_RS37460	COG2197	response regulator
SBI_RS37465	COG4585	Histidine kinase
SBI_RS37470	COG2030	dehydratase
SBI_RS37475	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SBI_RS37480	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS37490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SBI_RS37505	COG0800	Aldolase
SBI_RS37510	COG3022	response to hydroperoxide
SBI_RS37520	COG0513	Belongs to the DEAD box helicase family
SBI_RS37570	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SBI_RS37585	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS37590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS37600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS37640	COG2197	response regulator
SBI_RS37650	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS37655	COG3540	Alkaline phosphatase
SBI_RS37695	COG2814	Major facilitator Superfamily
SBI_RS37700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SBI_RS37720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SBI_RS37730	COG1834	amidinotransferase
SBI_RS37755	COG0672	)-iron permease
SBI_RS37760	COG2837	iron assimilation
SBI_RS37805	COG1175	transmembrane transport
SBI_RS37810	COG0395	ABC-type sugar transport system, permease component
SBI_RS37825	COG1994	Peptidase M50
SBI_RS37845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SBI_RS37850	COG0477	Major facilitator Superfamily
SBI_RS37855	COG1309	transcriptional regulator
SBI_RS37865	COG2814	Major facilitator Superfamily
SBI_RS37870	COG2267	carboxylic ester hydrolase activity
SBI_RS37875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SBI_RS37875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SBI_RS37880	COG2132	Multicopper oxidase
SBI_RS37885	COG0174	glutamine synthetase
SBI_RS37900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS37905	COG1960	acyl-CoA dehydrogenase activity
SBI_RS37920	COG1733	regulation of RNA biosynthetic process
SBI_RS37945	COG1309	transcriptional regulator
SBI_RS37970	COG1660	Displays ATPase and GTPase activities
SBI_RS37985	COG1595	DNA-templated transcription, initiation
SBI_RS38000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SBI_RS38005	COG0561	phosphatase activity
SBI_RS38015	COG1609	Transcriptional regulator
SBI_RS38020	COG0366	Alpha amylase catalytic
SBI_RS38025	COG2182	Extracellular solute-binding protein
SBI_RS38035	COG3833	ABC-type maltose transport systems, permease component
SBI_RS38040	COG2208	phosphoserine phosphatase activity
SBI_RS38040	COG2172	sigma factor antagonist activity
SBI_RS38040	COG1366	Belongs to the anti-sigma-factor antagonist family
SBI_RS38095	COG2815	serine threonine protein kinase
SBI_RS38095	COG0515	serine threonine protein kinase
SBI_RS38100	COG2197	response regulator
SBI_RS38165	COG0745	RESPONSE REGULATOR receiver
SBI_RS38190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SBI_RS38195	COG4214	carbohydrate transport
SBI_RS38205	COG4213	ABC transporter substrate-binding protein
SBI_RS38220	COG0174	glutamine synthetase
SBI_RS38240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SBI_RS38245	COG0321	lipoyl(octanoyl) transferase activity
SBI_RS38275	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS38285	COG2132	Multicopper oxidase
SBI_RS38300	COG0508	dehydrogenase complex catalyzes the overall conversion of
SBI_RS38305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SBI_RS38310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SBI_RS38315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SBI_RS38325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SBI_RS38325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SBI_RS38330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SBI_RS38370	COG4585	Histidine kinase
SBI_RS38375	COG2197	response regulator
SBI_RS38380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SBI_RS38395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SBI_RS38400	COG1104	cysteine desulfurase activity
SBI_RS38405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SBI_RS38410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SBI_RS38420	COG1376	ErfK ybiS ycfS ynhG family protein
SBI_RS38430	COG1845	cytochrome c oxidase, subunit III
SBI_RS38435	COG2010	Cytochrome c
SBI_RS38440	COG0723	plastoquinol--plastocyanin reductase activity
SBI_RS38445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SBI_RS38450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SBI_RS38455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SBI_RS38480	COG0791	NLP P60 protein
SBI_RS38485	COG0791	NLP P60 protein
SBI_RS38500	COG0534	Mate efflux family protein
SBI_RS38505	COG0438	transferase activity, transferring glycosyl groups
SBI_RS38525	COG0003	Pfam Anion-transporting ATPase
SBI_RS38535	COG1940	carbohydrate kinase activity
SBI_RS38560	COG4585	Histidine kinase
SBI_RS38570	COG0205	6-phosphofructokinase activity
SBI_RS38580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SBI_RS38585	COG0243	molybdopterin cofactor binding
SBI_RS38590	COG2193	ferroxidase activity
SBI_RS38595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SBI_RS38605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SBI_RS38610	COG2815	serine threonine protein kinase
SBI_RS38610	COG0515	serine threonine protein kinase
SBI_RS38620	COG2022	thiamine diphosphate biosynthetic process
SBI_RS38630	COG2022	thiamine diphosphate biosynthetic process
SBI_RS38630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SBI_RS38645	COG0352	thiamine-phosphate diphosphorylase activity
SBI_RS38660	COG1233	COG1233 Phytoene dehydrogenase and related
SBI_RS38665	COG1309	transcriptional regulator
SBI_RS38675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS38695	COG0714	Associated with various cellular activities
SBI_RS38705	COG0275	rRNA processing
SBI_RS38725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SBI_RS38730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SBI_RS38735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SBI_RS38740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SBI_RS38750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SBI_RS38755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SBI_RS38760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SBI_RS38765	COG1496	oxidoreductase activity
SBI_RS38775	COG1799	cell septum assembly
SBI_RS38790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SBI_RS38800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SBI_RS38840	COG0587	DNA-directed DNA polymerase activity
SBI_RS38850	COG1432	Conserved Protein
SBI_RS38865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SBI_RS38870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SBI_RS38880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SBI_RS38885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SBI_RS38890	COG0131	Imidazoleglycerol-phosphate dehydratase
SBI_RS38900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SBI_RS38905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SBI_RS38910	COG0251	oxidation-reduction process
SBI_RS38915	COG0107	imidazoleglycerol-phosphate synthase activity
SBI_RS38940	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS38965	COG2132	Multicopper oxidase
SBI_RS39000	COG2186	Transcriptional regulator
SBI_RS39005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SBI_RS39020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SBI_RS39045	COG0134	indole-3-glycerol-phosphate synthase activity
SBI_RS39050	COG0133	tryptophan synthase activity
SBI_RS39055	COG0159	tryptophan synthase activity
SBI_RS39065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SBI_RS39075	COG0070	glutamate synthase
SBI_RS39075	COG0069	glutamate synthase activity
SBI_RS39075	COG0067	glutamate synthase
SBI_RS39085	COG1725	Transcriptional regulator
SBI_RS39090	COG1131	(ABC) transporter
SBI_RS39110	COG3467	pyridoxamine 5'-phosphate
SBI_RS39125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SBI_RS39135	COG0287	Prephenate dehydrogenase
SBI_RS39135	COG1605	Chorismate mutase
SBI_RS39155	COG1140	nitrate reductase beta subunit
SBI_RS39160	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SBI_RS39170	COG1846	Transcriptional regulator
SBI_RS39185	COG1051	belongs to the nudix hydrolase family
SBI_RS39245	COG2050	protein possibly involved in aromatic compounds catabolism
SBI_RS39275	COG1643	Atp-dependent helicase
SBI_RS39280	COG2226	methyltransferase
SBI_RS39285	COG0539	negative regulation of cytoplasmic translation
SBI_RS39300	COG0237	dephospho-CoA kinase activity
SBI_RS39345	COG3321	synthase
SBI_RS39345	COG0604	alcohol dehydrogenase
SBI_RS39350	COG0667	Aldo Keto reductase
SBI_RS39355	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS39380	COG3629	intracellular signal transduction
SBI_RS39380	COG3903	Transcriptional regulator
SBI_RS39410	COG0584	glycerophosphoryl diester phosphodiesterase
SBI_RS39415	COG0556	nucleotide-excision repair
SBI_RS39435	COG0477	Major facilitator Superfamily
SBI_RS39450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SBI_RS39460	COG1609	Transcriptional regulator
SBI_RS39465	COG0322	excinuclease ABC activity
SBI_RS39470	COG1660	Displays ATPase and GTPase activities
SBI_RS39475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SBI_RS39480	COG1481	regulation of sporulation
SBI_RS39490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SBI_RS39495	COG0126	phosphoglycerate kinase activity
SBI_RS39500	COG0149	triose-phosphate isomerase activity
SBI_RS39505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SBI_RS39520	COG0166	Belongs to the GPI family
SBI_RS39525	COG0363	glucosamine-6-phosphate deaminase activity
SBI_RS39540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SBI_RS39550	COG0109	protoheme IX farnesyltransferase activity
SBI_RS39590	COG0719	Fe-S assembly protein
SBI_RS39600	COG0396	ATPase activity
SBI_RS39605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SBI_RS39610	COG0822	iron-sulfur transferase activity
SBI_RS39620	COG2076	Multidrug Resistance protein
SBI_RS39625	COG3226	Transcriptional regulator
SBI_RS39630	COG2171	N-acyltransferase activity
SBI_RS39635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS39690	COG0667	Aldo Keto reductase
SBI_RS39695	COG2207	Transcriptional regulator
SBI_RS39745	COG2188	Transcriptional regulator
SBI_RS39750	COG1301	dicarboxylic acid transport
SBI_RS39760	COG1733	regulation of RNA biosynthetic process
SBI_RS39765	COG0596	Alpha beta hydrolase
SBI_RS39780	COG0574	Belongs to the PEP-utilizing enzyme family
SBI_RS39780	COG3848	Pyruvate phosphate dikinase
SBI_RS39795	COG1846	Transcriptional regulator
SBI_RS39800	COG0477	Major facilitator Superfamily
SBI_RS39820	COG0583	DNA-binding transcription factor activity
SBI_RS39835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SBI_RS39840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS39850	COG1802	Transcriptional regulator
SBI_RS39870	COG0395	ABC-type sugar transport system, permease component
SBI_RS39875	COG3866	Pectate lyase
SBI_RS39890	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS39895	COG3866	Pectate lyase
SBI_RS39905	COG2755	lipolytic protein G-D-S-L family
SBI_RS39910	COG3866	Pectate lyase
SBI_RS39915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SBI_RS39925	COG2252	PERMEase
SBI_RS39930	COG0667	Aldo Keto reductase
SBI_RS39940	COG4585	Histidine kinase
SBI_RS39950	COG1414	Transcriptional regulator
SBI_RS39965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SBI_RS39970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SBI_RS39975	COG5285	phytanoyl-CoA dioxygenase
SBI_RS39980	COG1917	Cupin 2, conserved barrel domain protein
SBI_RS40030	COG1797	cobyrinic acid a,c-diamide synthase activity
SBI_RS40035	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SBI_RS40045	COG1492	cobalamin metabolic process
SBI_RS40065	COG0235	Class ii aldolase
SBI_RS40070	COG2267	carboxylic ester hydrolase activity
SBI_RS40080	COG0488	(ABC) transporter
SBI_RS40090	COG1024	Enoyl-CoA hydratase
SBI_RS40100	COG3437	response regulator, receiver
SBI_RS40100	COG4999	Histidine kinase
SBI_RS40100	COG3850	Histidine kinase
SBI_RS40100	COG2205	protein histidine kinase activity
SBI_RS40125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SBI_RS40150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SBI_RS40155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SBI_RS40170	COG2261	transglycosylase associated protein
SBI_RS40175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SBI_RS40225	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS40230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SBI_RS40240	COG2186	Transcriptional regulator
SBI_RS40245	COG2807	transmembrane transport
SBI_RS40260	COG3830	Belongs to the UPF0237 family
SBI_RS40260	COG0560	Phosphoserine phosphatase
SBI_RS40270	COG1131	(ABC) transporter
SBI_RS40270	COG0842	Transport permease protein
SBI_RS40270	COG1716	ATPase activity
SBI_RS40280	COG4585	Histidine kinase
SBI_RS40285	COG2197	response regulator
SBI_RS40300	COG1119	ATPase activity
SBI_RS40320	COG1881	PFAM PEBP family protein
SBI_RS40335	COG2094	Belongs to the DNA glycosylase MPG family
SBI_RS40340	COG2094	Belongs to the DNA glycosylase MPG family
SBI_RS40365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SBI_RS40370	COG2094	Belongs to the DNA glycosylase MPG family
SBI_RS40405	COG0647	UMP catabolic process
SBI_RS40410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS40415	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SBI_RS40420	COG1120	ATPase activity
SBI_RS40440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SBI_RS40445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS40450	COG0656	L-ascorbic acid biosynthetic process
SBI_RS40465	COG2814	Major facilitator Superfamily
SBI_RS40480	COG0497	DNA recombination
SBI_RS40485	COG0297	glycogen (starch) synthase activity
SBI_RS40495	COG3387	PFAM Glycoside hydrolase 15-related
SBI_RS40500	COG0504	CTP synthase activity
SBI_RS40505	COG0494	nUDIX hydrolase
SBI_RS40515	COG0686	Belongs to the AlaDH PNT family
SBI_RS40530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SBI_RS40535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SBI_RS40540	COG1187	pseudouridine synthase activity
SBI_RS40555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SBI_RS40565	COG1160	GTP binding
SBI_RS40580	COG0438	transferase activity, transferring glycosyl groups
SBI_RS40600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SBI_RS40610	COG0671	phosphoesterase, PA-phosphatase related
SBI_RS40620	COG0477	Major facilitator Superfamily
SBI_RS40625	COG1960	acyl-CoA dehydrogenase activity
SBI_RS40630	COG1799	cell septum assembly
SBI_RS40660	COG0330	HflC and HflK could
SBI_RS40695	COG0604	alcohol dehydrogenase
SBI_RS40695	COG3321	synthase
SBI_RS40700	COG3467	pyridoxamine 5'-phosphate
SBI_RS40705	COG0587	DNA-directed DNA polymerase activity
SBI_RS40710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SBI_RS40740	COG1764	response to oxidative stress
SBI_RS40745	COG1846	Transcriptional regulator
SBI_RS40760	COG2409	Drug exporters of the RND superfamily
SBI_RS40790	COG4264	IucA IucC family
SBI_RS40795	COG0019	diaminopimelate decarboxylase activity
SBI_RS40835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS40840	COG1846	Transcriptional regulator
SBI_RS40845	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS40845	COG3321	synthase
SBI_RS40845	COG0604	alcohol dehydrogenase
SBI_RS40900	COG0300	oxidoreductase activity
SBI_RS40910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SBI_RS40910	COG2080	2 iron, 2 sulfur cluster binding
SBI_RS40955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SBI_RS40970	COG1609	Transcriptional regulator
SBI_RS40995	COG2890	protein-(glutamine-N5) methyltransferase activity
SBI_RS41000	COG3629	intracellular signal transduction
SBI_RS41000	COG3903	Transcriptional regulator
SBI_RS41010	COG2197	response regulator
SBI_RS41035	COG1725	Transcriptional regulator
SBI_RS41040	COG1834	amidinotransferase
SBI_RS41065	COG0726	polysaccharide deacetylase
SBI_RS41065	COG1649	PFAM Uncharacterised BCR, COG1649
SBI_RS41070	COG1215	transferase activity, transferring glycosyl groups
SBI_RS41075	COG0463	Glycosyl transferase, family 2
SBI_RS41090	COG2755	lipolytic protein G-D-S-L family
SBI_RS41110	COG1595	DNA-templated transcription, initiation
SBI_RS41115	COG5343	regulation of RNA biosynthetic process
SBI_RS41130	COG2188	Transcriptional regulator
SBI_RS41135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SBI_RS41140	COG1309	transcriptional regulator
SBI_RS41145	COG0243	molybdopterin cofactor binding
SBI_RS41150	COG2851	Citrate transporter
SBI_RS41220	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS41230	COG1960	acyl-CoA dehydrogenase activity
SBI_RS41255	COG2149	membrane
SBI_RS41260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SBI_RS41275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SBI_RS41295	COG0438	transferase activity, transferring glycosyl groups
SBI_RS41305	COG1609	Transcriptional regulator
SBI_RS41340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS41345	COG0596	Alpha beta hydrolase
SBI_RS41390	COG3321	synthase
SBI_RS41390	COG0604	alcohol dehydrogenase
SBI_RS41395	COG3321	synthase
SBI_RS41395	COG0604	alcohol dehydrogenase
SBI_RS41400	COG3321	synthase
SBI_RS41400	COG0604	alcohol dehydrogenase
SBI_RS41415	COG3629	intracellular signal transduction
SBI_RS41440	COG2197	response regulator
SBI_RS41480	COG1914	H( )-stimulated, divalent metal cation uptake system
SBI_RS41485	COG2140	Oxalate decarboxylase
SBI_RS41525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SBI_RS41550	COG0667	Aldo Keto reductase
SBI_RS41555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS41565	COG0598	Magnesium transport protein CorA
SBI_RS41570	COG0406	alpha-ribazole phosphatase activity
SBI_RS41585	COG0215	cysteine-tRNA ligase activity
SBI_RS41600	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS41605	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS41615	COG1129	ABC transporter
SBI_RS41620	COG4211	Belongs to the binding-protein-dependent transport system permease family
SBI_RS41630	COG3618	amidohydrolase
SBI_RS41635	COG2186	Transcriptional regulator
SBI_RS41645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SBI_RS41650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SBI_RS41655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SBI_RS41660	COG1414	Transcriptional regulator
SBI_RS41665	COG1410	methionine synthase
SBI_RS41665	COG0646	methionine synthase
SBI_RS41670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SBI_RS41680	COG2197	response regulator
SBI_RS41695	COG0517	IMP dehydrogenase activity
SBI_RS41695	COG1994	Peptidase M50
SBI_RS41715	COG1222	aaa ATPase
SBI_RS41720	COG4122	O-methyltransferase activity
SBI_RS41735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SBI_RS41740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SBI_RS41745	COG1609	Transcriptional regulator
SBI_RS41755	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SBI_RS41760	COG0545	Peptidyl-prolyl cis-trans isomerase
SBI_RS41770	COG2378	regulation of single-species biofilm formation
SBI_RS41790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SBI_RS41795	COG0805	protein transport
SBI_RS41830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SBI_RS41835	COG4175	Glycine betaine
SBI_RS41835	COG0517	IMP dehydrogenase activity
SBI_RS41845	COG1228	amidohydrolase
SBI_RS41850	COG2267	carboxylic ester hydrolase activity
SBI_RS41875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SBI_RS41935	COG4644	lycopene metabolic process
SBI_RS42045	COG2255	four-way junction helicase activity
SBI_RS42085	COG0076	glutamate decarboxylase activity
SBI_RS42100	COG0791	NLP P60 protein
SBI_RS42210	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS42230	COG3401	FG-GAP repeat protein
SBI_RS42240	COG0395	ABC-type sugar transport system, permease component
SBI_RS42245	COG1175	transmembrane transport
SBI_RS42260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SBI_RS42270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SBI_RS42295	COG0179	Fumarylacetoacetate (FAA) hydrolase
SBI_RS42300	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS42305	COG0531	amino acid
SBI_RS42310	COG0436	Aminotransferase
SBI_RS42325	COG1064	alcohol dehydrogenase
SBI_RS42340	COG4221	oxidoreductase activity
SBI_RS42345	COG3547	Transposase (IS116 IS110 IS902 family)
SBI_RS42350	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS42360	COG0251	oxidation-reduction process
SBI_RS42370	COG1802	Transcriptional regulator
SBI_RS42375	COG4221	oxidoreductase activity
SBI_RS42380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS42400	COG0583	DNA-binding transcription factor activity
SBI_RS42440	COG0395	ABC-type sugar transport system, permease component
SBI_RS42445	COG4209	transmembrane transport
SBI_RS42450	COG1653	transport
SBI_RS42455	COG5578	integral membrane protein
SBI_RS42460	COG1609	Transcriptional regulator
SBI_RS42475	COG2755	lipolytic protein G-D-S-L family
SBI_RS42485	COG3401	FG-GAP repeat protein
SBI_RS42495	COG0673	inositol 2-dehydrogenase activity
SBI_RS42545	COG0183	Belongs to the thiolase family
SBI_RS42550	COG1024	Enoyl-CoA hydratase
SBI_RS42560	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS42565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SBI_RS42570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS42575	COG1960	acyl-CoA dehydrogenase activity
SBI_RS42595	COG3226	Transcriptional regulator
SBI_RS42600	COG1960	acyl-CoA dehydrogenase activity
SBI_RS42645	COG0281	malic enzyme
SBI_RS42655	COG3473	Maleate cis-trans isomerase
SBI_RS42670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SBI_RS42680	COG1802	Transcriptional regulator
SBI_RS42685	COG1733	regulation of RNA biosynthetic process
SBI_RS42700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SBI_RS42775	COG0366	Alpha amylase catalytic
SBI_RS42780	COG0395	ABC-type sugar transport system, permease component
SBI_RS42795	COG1609	Transcriptional regulator
SBI_RS42960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SBI_RS43000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SBI_RS43010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SBI_RS43010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SBI_RS43045	COG2318	DinB family
SBI_RS43055	COG0384	phenazine biosynthesis protein PhzF
SBI_RS43060	COG1695	Transcriptional regulator
SBI_RS43135	COG0667	Aldo Keto reductase
SBI_RS43140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SBI_RS43150	COG2378	regulation of single-species biofilm formation
SBI_RS43165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SBI_RS43175	COG1172	Belongs to the binding-protein-dependent transport system permease family
SBI_RS43180	COG1129	ABC transporter
SBI_RS43185	COG4213	ABC transporter substrate-binding protein
SBI_RS43190	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS43195	COG2186	Transcriptional regulator
SBI_RS43200	COG1113	amino acid transport
SBI_RS43215	COG3284	Transcriptional regulator
SBI_RS43240	COG0747	negative chemotaxis
SBI_RS43250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS43265	COG4172	Belongs to the ABC transporter superfamily
SBI_RS43285	COG3511	phospholipase C
SBI_RS43295	COG2814	Major facilitator Superfamily
SBI_RS43300	COG0765	amino acid transport
SBI_RS43305	COG1126	abc transporter atp-binding protein
SBI_RS43320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SBI_RS43330	COG1968	undecaprenyl-diphosphatase activity
SBI_RS43340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SBI_RS43390	COG1832	CoA-binding protein
SBI_RS43395	COG1739	Uncharacterized protein family UPF0029
SBI_RS43410	COG3209	COG3209 Rhs family protein
SBI_RS43415	COG0420	3'-5' exonuclease activity
SBI_RS43420	COG0419	ATPase involved in DNA repair
SBI_RS43455	COG2267	carboxylic ester hydrolase activity
SBI_RS43460	COG1595	DNA-templated transcription, initiation
SBI_RS43465	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS43470	COG2188	Transcriptional regulator
SBI_RS43500	COG1940	carbohydrate kinase activity
SBI_RS43505	COG2197	response regulator
SBI_RS43510	COG4585	Histidine kinase
SBI_RS43515	COG1131	(ABC) transporter
SBI_RS43535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SBI_RS43585	COG1472	Belongs to the glycosyl hydrolase 3 family
SBI_RS43590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SBI_RS43595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SBI_RS43600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SBI_RS43635	COG0791	NLP P60 protein
SBI_RS43645	COG0740	serine-type endopeptidase activity
SBI_RS43655	COG0831	urea catabolic process
SBI_RS43660	COG0832	Belongs to the urease beta subunit family
SBI_RS43665	COG0804	urea catabolic process
SBI_RS43670	COG0830	nickel cation binding
SBI_RS43675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SBI_RS43680	COG0829	nickel cation binding
SBI_RS43735	COG0205	6-phosphofructokinase activity
SBI_RS43740	COG3442	glutamine amidotransferase
SBI_RS43750	COG0242	peptide deformylase activity
SBI_RS43760	COG1960	acyl-CoA dehydrogenase activity
SBI_RS43790	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS43805	COG0702	epimerase
SBI_RS43825	COG0252	asparaginase activity
SBI_RS43835	COG1793	dna ligase
SBI_RS43845	COG1191	sigma factor activity
SBI_RS43855	COG1132	(ABC) transporter
SBI_RS43865	COG1349	DNA-binding transcription factor activity
SBI_RS43870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SBI_RS43875	COG3395	kinase activity
SBI_RS43880	COG0747	negative chemotaxis
SBI_RS43885	COG0601	transmembrane transport
SBI_RS43890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS43900	COG4608	Belongs to the ABC transporter superfamily
SBI_RS43905	COG0667	Aldo Keto reductase
SBI_RS43915	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS43920	COG2356	endonuclease I
SBI_RS43935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SBI_RS44020	COG1280	lysine exporter protein (LysE YggA)
SBI_RS44040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SBI_RS44045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SBI_RS44050	COG2080	2 iron, 2 sulfur cluster binding
SBI_RS44075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SBI_RS44085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SBI_RS44095	COG1609	Transcriptional regulator
SBI_RS44115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SBI_RS44275	COG0464	growth
SBI_RS44295	COG2197	response regulator
SBI_RS44315	COG3012	SEC-C Motif Domain Protein
SBI_RS44320	COG0246	Mannitol dehydrogenase
SBI_RS44355	COG1132	(ABC) transporter
SBI_RS44400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SBI_RS44545	COG0535	radical SAM domain protein
SBI_RS44560	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS44560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS44560	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS44560	COG3321	synthase
SBI_RS44560	COG0300	oxidoreductase activity
SBI_RS44570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SBI_RS44580	COG2192	nodulation
SBI_RS44595	COG3250	beta-galactosidase activity
SBI_RS44610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SBI_RS44615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SBI_RS44620	COG2205	protein histidine kinase activity
SBI_RS44625	COG0745	RESPONSE REGULATOR receiver
SBI_RS44645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SBI_RS44670	COG0242	peptide deformylase activity
SBI_RS44675	COG0006	proline dipeptidase activity
SBI_RS44690	COG0156	8-amino-7-oxononanoate synthase activity
SBI_RS44700	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SBI_RS44705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SBI_RS44710	COG2423	ornithine cyclodeaminase activity
SBI_RS44745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS44755	COG3250	beta-galactosidase activity
SBI_RS44785	COG1063	alcohol dehydrogenase
SBI_RS44805	COG0277	FAD linked oxidase domain protein
SBI_RS44815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SBI_RS44850	COG3540	Alkaline phosphatase
SBI_RS44855	COG0640	Transcriptional regulator
SBI_RS44875	COG1126	abc transporter atp-binding protein
SBI_RS44880	COG0765	amino acid transport
SBI_RS44885	COG0477	Major facilitator Superfamily
SBI_RS44900	COG0640	Transcriptional regulator
SBI_RS44930	COG3290	protein histidine kinase activity
SBI_RS44940	COG2340	Cysteine-rich secretory protein family
SBI_RS44945	COG0701	Predicted permease
SBI_RS44990	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS45005	COG0402	S-adenosylhomocysteine deaminase activity
SBI_RS45030	COG1609	Transcriptional regulator
SBI_RS45040	COG0395	ABC-type sugar transport system, permease component
SBI_RS45045	COG4209	transmembrane transport
SBI_RS45080	COG2814	Major facilitator Superfamily
SBI_RS45090	COG0596	Alpha beta hydrolase
SBI_RS45105	COG1335	isochorismatase
SBI_RS45110	COG2259	Doxx family
SBI_RS45115	COG3619	membrane
SBI_RS45125	COG3629	intracellular signal transduction
SBI_RS45125	COG3903	Transcriptional regulator
SBI_RS45130	COG3629	intracellular signal transduction
SBI_RS45130	COG3903	Transcriptional regulator
SBI_RS45135	COG2197	response regulator
SBI_RS45145	COG0137	argininosuccinate synthase activity
SBI_RS45175	COG1301	dicarboxylic acid transport
SBI_RS45180	COG0583	DNA-binding transcription factor activity
SBI_RS45190	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS45205	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS45215	COG2267	carboxylic ester hydrolase activity
SBI_RS45225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS45225	COG3320	Male sterility
SBI_RS45230	COG3321	synthase
SBI_RS45230	COG0604	alcohol dehydrogenase
SBI_RS45235	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS45290	COG1609	Transcriptional regulator
SBI_RS45300	COG0673	inositol 2-dehydrogenase activity
SBI_RS45305	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS45330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS45335	COG0667	Aldo Keto reductase
SBI_RS45340	COG2610	gluconate transmembrane transporter activity
SBI_RS45345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS45355	COG0583	DNA-binding transcription factor activity
SBI_RS45365	COG5006	permease, DMT superfamily
SBI_RS45370	COG1609	Transcriptional regulator
SBI_RS45375	COG0673	inositol 2-dehydrogenase activity
SBI_RS45380	COG1073	alpha beta
SBI_RS45410	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS45470	COG0464	growth
SBI_RS45480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SBI_RS45515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS45525	COG2175	clavaminate synthase activity
SBI_RS45530	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS45555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SBI_RS45565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS45590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SBI_RS45595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SBI_RS45600	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SBI_RS45615	COG0395	ABC-type sugar transport system, permease component
SBI_RS45630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SBI_RS45650	COG4585	Histidine kinase
SBI_RS45655	COG2197	response regulator
SBI_RS45715	COG1349	DNA-binding transcription factor activity
SBI_RS45725	COG0464	growth
SBI_RS45750	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SBI_RS45790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SBI_RS45820	COG1902	pentaerythritol trinitrate reductase activity
SBI_RS45920	COG3293	Transposase
SBI_RS45940	COG1309	transcriptional regulator
SBI_RS45945	COG1064	alcohol dehydrogenase
SBI_RS45985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SBI_RS45995	COG0667	Aldo Keto reductase
SBI_RS46020	COG0640	Transcriptional regulator
SBI_RS46030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SBI_RS46055	COG2814	Major facilitator Superfamily
SBI_RS46080	COG2723	6-phospho-beta-galactosidase activity
SBI_RS46085	COG0395	ABC-type sugar transport system, permease component
SBI_RS46090	COG1175	transmembrane transport
SBI_RS46100	COG1940	carbohydrate kinase activity
SBI_RS46145	COG0673	inositol 2-dehydrogenase activity
SBI_RS46170	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS46180	COG1653	transport
SBI_RS46185	COG1175	transmembrane transport
SBI_RS46190	COG0395	ABC-type sugar transport system, permease component
SBI_RS46195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SBI_RS46205	COG2273	Hydrolase Family 16
SBI_RS46210	COG1609	Transcriptional regulator
SBI_RS46230	COG5006	permease, DMT superfamily
SBI_RS46295	COG1595	DNA-templated transcription, initiation
SBI_RS46320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SBI_RS46350	COG1396	sequence-specific DNA binding
SBI_RS46400	COG1088	dTDP-glucose 4,6-dehydratase activity
SBI_RS46405	COG1819	glycosyl
SBI_RS46415	COG1819	glycosyl
SBI_RS46465	COG1349	DNA-binding transcription factor activity
SBI_RS46470	COG4213	ABC transporter substrate-binding protein
SBI_RS46480	COG4214	carbohydrate transport
SBI_RS46485	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS46495	COG2358	TRAP transporter, solute receptor (TAXI family
SBI_RS46505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SBI_RS46510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46540	COG0559	Belongs to the binding-protein-dependent transport system permease family
SBI_RS46560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SBI_RS46605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS46610	COG4172	Belongs to the ABC transporter superfamily
SBI_RS46620	COG3226	Transcriptional regulator
SBI_RS46625	COG0738	Major facilitator superfamily
SBI_RS46630	COG0842	Transport permease protein
SBI_RS46630	COG1716	ATPase activity
SBI_RS46630	COG1131	(ABC) transporter
SBI_RS46635	COG3629	intracellular signal transduction
SBI_RS46635	COG3903	Transcriptional regulator
SBI_RS46680	COG1064	alcohol dehydrogenase
SBI_RS46700	COG4221	oxidoreductase activity
SBI_RS46730	COG0187	DNA topoisomerase II activity
SBI_RS46745	COG1609	Transcriptional regulator
SBI_RS46760	COG4154	Belongs to the RbsD FucU family
SBI_RS46765	COG3250	beta-galactosidase activity
SBI_RS46770	COG2205	protein histidine kinase activity
SBI_RS46775	COG0745	RESPONSE REGULATOR receiver
SBI_RS46815	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS46830	COG1940	carbohydrate kinase activity
SBI_RS46830	COG1846	Transcriptional regulator
SBI_RS46880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SBI_RS46885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SBI_RS46905	COG0367	asparagine synthase
SBI_RS46930	COG0438	transferase activity, transferring glycosyl groups
SBI_RS46940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SBI_RS46955	COG4310	Domain of unknown function (DUF2172)
SBI_RS46965	COG1215	transferase activity, transferring glycosyl groups
SBI_RS46975	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SBI_RS46980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SBI_RS47000	COG4221	oxidoreductase activity
SBI_RS47015	COG1733	regulation of RNA biosynthetic process
SBI_RS47045	COG4977	sequence-specific DNA binding
SBI_RS47055	COG0477	Major facilitator Superfamily
SBI_RS47060	COG0477	Major facilitator Superfamily
SBI_RS47080	COG2205	protein histidine kinase activity
SBI_RS47085	COG0745	RESPONSE REGULATOR receiver
SBI_RS47100	COG0586	Pfam SNARE associated Golgi protein
SBI_RS47135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS47145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SBI_RS47165	COG4221	oxidoreductase activity
SBI_RS47170	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS47185	COG0745	RESPONSE REGULATOR receiver
SBI_RS47190	COG2205	protein histidine kinase activity
SBI_RS47220	COG2409	Drug exporters of the RND superfamily
SBI_RS47225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SBI_RS47245	COG0402	S-adenosylhomocysteine deaminase activity
SBI_RS47265	COG1090	epimerase
SBI_RS47310	COG0673	inositol 2-dehydrogenase activity
SBI_RS47360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SBI_RS47395	COG2070	2-Nitropropane dioxygenase
SBI_RS47395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SBI_RS47405	COG3321	synthase
SBI_RS47405	COG0300	oxidoreductase activity
SBI_RS47405	COG4221	oxidoreductase activity
SBI_RS47405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SBI_RS47420	COG0300	oxidoreductase activity
SBI_RS47420	COG0318	PFAM AMP-dependent synthetase and ligase
SBI_RS47420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS47420	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS47420	COG3321	synthase
SBI_RS47425	COG1250	3-hydroxyacyl-CoA dehydrogenase
SBI_RS47440	COG1960	acyl-CoA dehydrogenase activity
SBI_RS47455	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS47455	COG4221	oxidoreductase activity
SBI_RS47455	COG3321	synthase
SBI_RS47455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SBI_RS47485	COG1309	transcriptional regulator
SBI_RS47495	COG1131	(ABC) transporter
SBI_RS47530	COG0477	Major facilitator Superfamily
SBI_RS47560	COG2124	cytochrome p450
SBI_RS47565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SBI_RS47575	COG4585	Histidine kinase
SBI_RS47595	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS47600	COG3250	beta-galactosidase activity
SBI_RS47610	COG4829	muconolactone delta-isomerase
SBI_RS47615	COG3485	protocatechuate 3,4-dioxygenase
SBI_RS47620	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS47625	COG0154	amidase activity
SBI_RS47635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SBI_RS47650	COG4638	Rieske (2fe-2S)
SBI_RS47660	COG1960	acyl-CoA dehydrogenase activity
SBI_RS47665	COG1228	amidohydrolase
SBI_RS47670	COG3852	Histidine kinase
SBI_RS47675	COG4566	intracellular signal transduction
SBI_RS47700	COG0601	transmembrane transport
SBI_RS47720	COG1082	Xylose isomerase domain protein TIM barrel
SBI_RS47730	COG1846	Transcriptional regulator
SBI_RS47730	COG1940	carbohydrate kinase activity
SBI_RS47790	COG4221	oxidoreductase activity
SBI_RS47800	COG2409	Drug exporters of the RND superfamily
SBI_RS47825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SBI_RS47835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SBI_RS47840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SBI_RS47850	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS47855	COG1012	belongs to the aldehyde dehydrogenase family
SBI_RS47865	COG3842	ATPase activity
SBI_RS47870	COG1176	ABC-type spermidine putrescine transport system, permease component I
SBI_RS47875	COG1177	transmembrane transport
SBI_RS47880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SBI_RS47930	COG0596	Alpha beta hydrolase
SBI_RS47960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SBI_RS47980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SBI_RS47985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SBI_RS48015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SBI_RS48020	COG3345	alpha-galactosidase
SBI_RS48025	COG1609	Transcriptional regulator
SBI_RS48040	COG2132	Multicopper oxidase
SBI_RS48060	COG1233	COG1233 Phytoene dehydrogenase and related
SBI_RS48070	COG4608	Belongs to the ABC transporter superfamily
SBI_RS48075	COG0444	Belongs to the ABC transporter superfamily
SBI_RS48080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SBI_RS48085	COG0601	transmembrane transport
SBI_RS48125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SBI_RS48130	COG3409	Peptidoglycan-binding domain 1 protein
SBI_RS48145	COG1309	transcriptional regulator
SBI_RS48150	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS48245	COG4974	Belongs to the 'phage' integrase family
SBI_RS48280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SBI_RS48310	COG0183	Belongs to the thiolase family
SBI_RS48315	COG1024	Enoyl-CoA hydratase
SBI_RS48320	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS48325	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS48340	COG1960	acyl-CoA dehydrogenase activity
SBI_RS48345	COG0183	Belongs to the thiolase family
SBI_RS48355	COG1024	Enoyl-CoA hydratase
SBI_RS48365	COG1960	acyl-CoA dehydrogenase activity
SBI_RS48390	COG1960	acyl-CoA dehydrogenase activity
SBI_RS48405	COG2814	Major facilitator Superfamily
SBI_RS48515	COG2409	Drug exporters of the RND superfamily
SBI_RS48530	COG2828	Protein conserved in bacteria
SBI_RS48535	COG1301	dicarboxylic acid transport
SBI_RS48550	COG0515	serine threonine protein kinase
SBI_RS48550	COG2815	serine threonine protein kinase
SBI_RS48585	COG0300	oxidoreductase activity
SBI_RS48590	COG2815	serine threonine protein kinase
SBI_RS48590	COG0515	serine threonine protein kinase
SBI_RS48630	COG1487	ribonuclease activity
SBI_RS48665	COG3250	beta-galactosidase activity
SBI_RS48685	COG3507	Belongs to the glycosyl hydrolase 43 family
SBI_RS48695	COG1609	Transcriptional regulator
SBI_RS48710	COG4948	Mandelate Racemase Muconate Lactonizing
SBI_RS48715	COG3618	amidohydrolase
SBI_RS48725	COG1063	alcohol dehydrogenase
SBI_RS48730	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS48740	COG1609	Transcriptional regulator
SBI_RS48750	COG3345	alpha-galactosidase
SBI_RS48785	COG0395	ABC-type sugar transport system, permease component
SBI_RS48790	COG4209	transmembrane transport
SBI_RS48795	COG1609	Transcriptional regulator
SBI_RS48815	COG2186	Transcriptional regulator
SBI_RS48830	COG0395	ABC-type sugar transport system, permease component
SBI_RS48845	COG3693	PFAM glycoside hydrolase, family 10
SBI_RS48845	COG3509	depolymerase
SBI_RS48860	COG2755	lipolytic protein G-D-S-L family
SBI_RS48865	COG1609	Transcriptional regulator
SBI_RS48880	COG3458	cephalosporin-C deacetylase activity
SBI_RS48910	COG2207	Transcriptional regulator
SBI_RS48910	COG1609	Transcriptional regulator
SBI_RS48935	COG0395	ABC-type sugar transport system, permease component
SBI_RS48940	COG4209	transmembrane transport
SBI_RS48955	COG1501	Belongs to the glycosyl hydrolase 31 family
SBI_RS49025	COG1028	Short-chain dehydrogenase reductase Sdr
SBI_RS49030	COG1959	2 iron, 2 sulfur cluster binding
SBI_RS49045	COG0745	RESPONSE REGULATOR receiver
SBI_RS49060	COG2205	protein histidine kinase activity
SBI_RS49210	COG0515	serine threonine protein kinase
SBI_RS49210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS49350	COG0477	Major facilitator Superfamily
SBI_RS49360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SBI_RS49375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SBI_RS49380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SBI_RS49475	COG1414	Transcriptional regulator
SBI_RS49495	COG1388	LysM domain
SBI_RS49495	COG4942	peptidase
SBI_RS49510	COG0515	serine threonine protein kinase
SBI_RS49510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS49560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SBI_RS49560	COG0515	serine threonine protein kinase
SBI_RS49640	COG5297	Belongs to the glycosyl hydrolase family 6
SBI_RS49655	COG3629	intracellular signal transduction
SBI_RS49655	COG3903	Transcriptional regulator
SBI_RS49685	COG4585	Histidine kinase
SBI_RS49760	COG0515	serine threonine protein kinase
SBI_RS49760	COG2815	serine threonine protein kinase
SBI_RS49870	COG3971	2-oxopent-4-enoate hydratase activity
SBI_RS49900	COG4584	PFAM Integrase catalytic
SBI_RS50005	COG0604	alcohol dehydrogenase
SBI_RS50005	COG3321	synthase
SBI_RS50035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SBI_RS50090	COG1262	PFAM Formylglycine-generating sulfatase enzyme