locus-tag	class	description
HUT08_RS00035	COG2801	Transposase and inactivated derivatives
HUT08_RS00075	COG1132	(ABC) transporter
HUT08_RS00080	COG1132	(ABC) transporter
HUT08_RS00105	COG2226	methyltransferase
HUT08_RS00130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUT08_RS00145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS00150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUT08_RS00165	COG1442	glycosyl transferase family 8
HUT08_RS00210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT08_RS00215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT08_RS00470	COG0640	Transcriptional regulator
HUT08_RS00520	COG2223	nitrite transmembrane transporter activity
HUT08_RS00560	COG3344	reverse transcriptase
HUT08_RS00635	COG1309	transcriptional regulator
HUT08_RS00665	COG1733	regulation of RNA biosynthetic process
HUT08_RS00670	COG0604	alcohol dehydrogenase
HUT08_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS00670	COG3321	synthase
HUT08_RS00725	COG0515	serine threonine protein kinase
HUT08_RS00725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS00735	COG3979	chitinase
HUT08_RS00745	COG2706	6-phosphogluconolactonase activity
HUT08_RS00790	COG0367	asparagine synthase
HUT08_RS00795	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS00810	COG0583	DNA-binding transcription factor activity
HUT08_RS00835	COG0596	Alpha beta hydrolase
HUT08_RS00860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT08_RS00930	COG2409	Drug exporters of the RND superfamily
HUT08_RS00935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUT08_RS00950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT08_RS00960	COG0142	geranyltranstransferase activity
HUT08_RS00990	COG1196	nuclear chromosome segregation
HUT08_RS00990	COG0739	heme binding
HUT08_RS00990	COG0741	lytic transglycosylase activity
HUT08_RS00995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT08_RS01040	COG1793	dna ligase
HUT08_RS01050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT08_RS01050	COG1796	DNA polymerase
HUT08_RS01055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT08_RS01060	COG1063	alcohol dehydrogenase
HUT08_RS01065	COG0395	ABC-type sugar transport system, permease component
HUT08_RS01080	COG1349	DNA-binding transcription factor activity
HUT08_RS01100	COG1132	(ABC) transporter
HUT08_RS01130	COG1946	Acyl-CoA thioesterase
HUT08_RS01140	COG2018	Roadblock/LC7 domain
HUT08_RS01170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT08_RS01180	COG2353	YceI-like domain
HUT08_RS01210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT08_RS01215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT08_RS01220	COG1124	(ABC) transporter
HUT08_RS01225	COG0444	Belongs to the ABC transporter superfamily
HUT08_RS01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS01235	COG0601	transmembrane transport
HUT08_RS01245	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS01250	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS01285	COG3850	Histidine kinase
HUT08_RS01315	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS01345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT08_RS01355	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT08_RS01360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUT08_RS01375	COG3360	Dodecin
HUT08_RS01395	COG2124	cytochrome p450
HUT08_RS01395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUT08_RS01405	COG0531	amino acid
HUT08_RS01420	COG3634	alkyl hydroperoxide reductase activity
HUT08_RS01430	COG1132	(ABC) transporter
HUT08_RS01435	COG4172	Belongs to the ABC transporter superfamily
HUT08_RS01450	COG0747	negative chemotaxis
HUT08_RS01465	COG4948	Mandelate Racemase Muconate Lactonizing
HUT08_RS01470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT08_RS01525	COG0640	Transcriptional regulator
HUT08_RS01545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT08_RS01555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT08_RS01610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT08_RS01710	COG1982	Orn Lys Arg decarboxylase major
HUT08_RS01720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUT08_RS01740	COG2207	Transcriptional regulator
HUT08_RS01800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS01815	COG1278	Cold shock
HUT08_RS01820	COG0395	ABC-type sugar transport system, permease component
HUT08_RS01825	COG1175	transmembrane transport
HUT08_RS01830	COG1653	transport
HUT08_RS01840	COG1175	transmembrane transport
HUT08_RS01850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT08_RS01850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT08_RS01860	COG1486	melibiose metabolic process
HUT08_RS01890	COG0673	inositol 2-dehydrogenase activity
HUT08_RS01900	COG3246	L-lysine catabolic process to acetate
HUT08_RS01905	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS01950	COG2755	lipolytic protein G-D-S-L family
HUT08_RS01965	COG5640	endopeptidase activity
HUT08_RS01970	COG2223	nitrite transmembrane transporter activity
HUT08_RS01975	COG2207	Transcriptional regulator
HUT08_RS01980	COG1959	2 iron, 2 sulfur cluster binding
HUT08_RS01985	COG0513	Belongs to the DEAD box helicase family
HUT08_RS01990	COG1278	Cold shock
HUT08_RS02000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUT08_RS02010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS02020	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT08_RS02025	COG2340	Cysteine-rich secretory protein family
HUT08_RS02095	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT08_RS02095	COG2319	Wd-40 repeat
HUT08_RS02105	COG4585	Histidine kinase
HUT08_RS02120	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS02125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS02155	COG4585	Histidine kinase
HUT08_RS02160	COG2197	response regulator
HUT08_RS02195	COG1309	transcriptional regulator
HUT08_RS02220	COG0640	Transcriptional regulator
HUT08_RS02225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS02230	COG1606	tRNA processing
HUT08_RS02235	COG1691	(AIR) carboxylase
HUT08_RS02240	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HUT08_RS02260	COG1902	pentaerythritol trinitrate reductase activity
HUT08_RS02265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT08_RS02285	COG2706	6-phosphogluconolactonase activity
HUT08_RS02290	COG3795	YCII-related domain
HUT08_RS02310	COG1522	sequence-specific DNA binding
HUT08_RS02315	COG0546	phosphoglycolate phosphatase activity
HUT08_RS02350	COG0590	tRNA wobble adenosine to inosine editing
HUT08_RS02365	COG0242	peptide deformylase activity
HUT08_RS02370	COG4941	Belongs to the sigma-70 factor family
HUT08_RS02375	COG3795	YCII-related domain
HUT08_RS02385	COG3973	AAA domain
HUT08_RS02400	COG0386	Belongs to the glutathione peroxidase family
HUT08_RS02405	COG2826	transposase and inactivated derivatives, IS30 family
HUT08_RS02425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT08_RS02440	COG1881	PFAM PEBP family protein
HUT08_RS02450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS02460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT08_RS02470	COG0713	ATP synthesis coupled electron transport
HUT08_RS02475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT08_RS02485	COG1007	ATP synthesis coupled electron transport
HUT08_RS02490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT08_RS02500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUT08_RS02515	COG1672	PFAM Archaeal ATPase
HUT08_RS02515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT08_RS02550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUT08_RS02565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT08_RS02575	COG0516	GMP reductase activity
HUT08_RS02575	COG0517	IMP dehydrogenase activity
HUT08_RS02580	COG2235	arginine
HUT08_RS02585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT08_RS02590	COG0549	Belongs to the carbamate kinase family
HUT08_RS02595	COG1288	antiporter activity
HUT08_RS02605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT08_RS02610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT08_RS02610	COG0574	Belongs to the PEP-utilizing enzyme family
HUT08_RS02630	COG0516	GMP reductase activity
HUT08_RS02630	COG0517	IMP dehydrogenase activity
HUT08_RS02655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT08_RS02690	COG1140	nitrate reductase beta subunit
HUT08_RS02695	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUT08_RS02705	COG1017	nitric oxide dioxygenase activity
HUT08_RS02705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT08_RS02715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUT08_RS02750	COG1454	alcohol dehydrogenase
HUT08_RS02750	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS02770	COG0432	Pfam Uncharacterised protein family UPF0047
HUT08_RS02775	COG1959	2 iron, 2 sulfur cluster binding
HUT08_RS02775	COG1295	ribonuclease BN
HUT08_RS02795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT08_RS02800	COG1116	anion transmembrane transporter activity
HUT08_RS02820	COG0247	lactate metabolic process
HUT08_RS02825	COG1139	Iron-sulfur cluster binding protein
HUT08_RS02830	COG1556	Lactate utilization protein
HUT08_RS02835	COG0154	amidase activity
HUT08_RS02855	COG2186	Transcriptional regulator
HUT08_RS02875	COG0463	Glycosyl transferase, family 2
HUT08_RS02910	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS02920	COG1309	transcriptional regulator
HUT08_RS02985	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS03020	COG4585	Histidine kinase
HUT08_RS03025	COG2197	response regulator
HUT08_RS03130	COG2318	DinB family
HUT08_RS03190	COG0367	asparagine synthase
HUT08_RS03195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT08_RS03205	COG0784	Response regulator, receiver
HUT08_RS03210	COG4251	negative regulation of phosphorylation
HUT08_RS03220	COG2318	DinB family
HUT08_RS03235	COG2226	methyltransferase
HUT08_RS03240	COG1090	epimerase
HUT08_RS03245	COG1454	alcohol dehydrogenase
HUT08_RS03250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT08_RS03255	COG1335	isochorismatase
HUT08_RS03275	COG1595	DNA-templated transcription, initiation
HUT08_RS03280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT08_RS03295	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUT08_RS03350	COG3409	Peptidoglycan-binding domain 1 protein
HUT08_RS03350	COG0793	Belongs to the peptidase S41A family
HUT08_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS03365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS03370	COG1024	Enoyl-CoA hydratase
HUT08_RS03375	COG3425	synthase
HUT08_RS03380	COG3321	synthase
HUT08_RS03380	COG0604	alcohol dehydrogenase
HUT08_RS03385	COG3321	synthase
HUT08_RS03385	COG0300	oxidoreductase activity
HUT08_RS03385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS03385	COG4221	oxidoreductase activity
HUT08_RS03390	COG4221	oxidoreductase activity
HUT08_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS03390	COG3321	synthase
HUT08_RS03395	COG0300	oxidoreductase activity
HUT08_RS03395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS03395	COG3321	synthase
HUT08_RS03395	COG4221	oxidoreductase activity
HUT08_RS03395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS03395	COG0300	oxidoreductase activity
HUT08_RS03395	COG3321	synthase
HUT08_RS03395	COG4221	oxidoreductase activity
HUT08_RS03400	COG3321	synthase
HUT08_RS03400	COG4221	oxidoreductase activity
HUT08_RS03400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS03400	COG0300	oxidoreductase activity
HUT08_RS03405	COG4221	oxidoreductase activity
HUT08_RS03405	COG3321	synthase
HUT08_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS03405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS03415	COG1024	Enoyl-CoA hydratase
HUT08_RS03420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUT08_RS03420	COG2070	2-Nitropropane dioxygenase
HUT08_RS03430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS03445	COG0328	RNA-DNA hybrid ribonuclease activity
HUT08_RS03480	COG0789	Transcriptional regulator
HUT08_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS03495	COG1309	transcriptional regulator
HUT08_RS03500	COG2205	protein histidine kinase activity
HUT08_RS03505	COG0745	RESPONSE REGULATOR receiver
HUT08_RS03515	COG1131	(ABC) transporter
HUT08_RS03555	COG0463	Glycosyl transferase, family 2
HUT08_RS03595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT08_RS03605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT08_RS03610	COG1879	ABC-type sugar transport system periplasmic component
HUT08_RS03670	COG2205	protein histidine kinase activity
HUT08_RS03675	COG0745	RESPONSE REGULATOR receiver
HUT08_RS03685	COG0477	Major facilitator Superfamily
HUT08_RS03705	COG0515	serine threonine protein kinase
HUT08_RS03715	COG1309	transcriptional regulator
HUT08_RS03725	COG2936	dipeptidyl-peptidase activity
HUT08_RS03730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT08_RS03735	COG0659	secondary active sulfate transmembrane transporter activity
HUT08_RS03785	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUT08_RS03915	COG0464	growth
HUT08_RS03960	COG3469	chitinase activity
HUT08_RS03965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT08_RS03975	COG3959	Transketolase, thiamine diphosphate binding domain
HUT08_RS03980	COG3958	Transketolase
HUT08_RS03985	COG1228	amidohydrolase
HUT08_RS03995	COG2364	Membrane
HUT08_RS04000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS04030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT08_RS04030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT08_RS04170	COG3953	SLT domain
HUT08_RS04170	COG5412	phage tail tape measure protein
HUT08_RS04245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT08_RS04320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS04355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUT08_RS04385	COG2755	lipolytic protein G-D-S-L family
HUT08_RS04410	COG1657	PFAM Prenyltransferase squalene oxidase
HUT08_RS04420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT08_RS04430	COG1562	ergosterol biosynthetic process
HUT08_RS04440	COG1134	teichoic acid transport
HUT08_RS04485	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT08_RS04495	COG1024	Enoyl-CoA hydratase
HUT08_RS04505	COG2183	response to ionizing radiation
HUT08_RS04510	COG0596	Alpha beta hydrolase
HUT08_RS04520	COG0488	(ABC) transporter
HUT08_RS04530	COG0488	(ABC) transporter
HUT08_RS04555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT08_RS04560	COG2936	dipeptidyl-peptidase activity
HUT08_RS04585	COG1113	amino acid transport
HUT08_RS04610	COG1024	Enoyl-CoA hydratase
HUT08_RS04610	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS04615	COG0183	Belongs to the thiolase family
HUT08_RS04625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT08_RS04650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT08_RS04655	COG3268	Saccharopine dehydrogenase
HUT08_RS04670	COG1515	deoxyribonuclease V activity
HUT08_RS04700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUT08_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS04725	COG4172	Belongs to the ABC transporter superfamily
HUT08_RS04745	COG4585	Histidine kinase
HUT08_RS04750	COG0671	phosphoesterase, PA-phosphatase related
HUT08_RS04775	COG0640	Transcriptional regulator
HUT08_RS04790	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HUT08_RS04795	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HUT08_RS04800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT08_RS04800	COG0235	Class ii aldolase
HUT08_RS04805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT08_RS04805	COG0235	Class ii aldolase
HUT08_RS04810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS04825	COG1126	abc transporter atp-binding protein
HUT08_RS04830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT08_RS04840	COG0431	NADPH-dependent FMN reductase
HUT08_RS04845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS04850	COG1595	DNA-templated transcription, initiation
HUT08_RS04875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT08_RS04880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT08_RS04915	COG0697	spore germination
HUT08_RS04920	COG1522	sequence-specific DNA binding
HUT08_RS04955	COG4326	sporulation control protein
HUT08_RS05030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT08_RS05045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS05080	COG3540	Alkaline phosphatase
HUT08_RS05085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT08_RS05090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT08_RS05145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT08_RS05160	COG4310	Domain of unknown function (DUF2172)
HUT08_RS05170	COG1215	transferase activity, transferring glycosyl groups
HUT08_RS05185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT08_RS05195	COG1404	Belongs to the peptidase S8 family
HUT08_RS05215	COG0187	DNA topoisomerase II activity
HUT08_RS05230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT08_RS05270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT08_RS05305	COG0583	DNA-binding transcription factor activity
HUT08_RS05335	COG0656	L-ascorbic acid biosynthetic process
HUT08_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS05345	COG0583	DNA-binding transcription factor activity
HUT08_RS05375	COG1595	DNA-templated transcription, initiation
HUT08_RS05385	COG1302	Protein conserved in bacteria
HUT08_RS05390	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT08_RS05415	COG1191	sigma factor activity
HUT08_RS05420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT08_RS05435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT08_RS05445	COG2409	Drug exporters of the RND superfamily
HUT08_RS05450	COG4585	Histidine kinase
HUT08_RS05480	COG5492	domain, Protein
HUT08_RS05500	COG1309	transcriptional regulator
HUT08_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS05520	COG0531	amino acid
HUT08_RS05535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT08_RS05605	COG0693	protein deglycase activity
HUT08_RS05615	COG0517	IMP dehydrogenase activity
HUT08_RS05620	COG1597	lipid kinase activity
HUT08_RS05640	COG0300	oxidoreductase activity
HUT08_RS05655	COG2382	esterase
HUT08_RS05730	COG2267	carboxylic ester hydrolase activity
HUT08_RS05735	COG0596	Alpha beta hydrolase
HUT08_RS05740	COG2770	Histidine kinase
HUT08_RS05740	COG2208	phosphoserine phosphatase activity
HUT08_RS05770	COG0789	Transcriptional regulator
HUT08_RS05780	COG1595	DNA-templated transcription, initiation
HUT08_RS05810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS05810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS05815	COG3433	isochorismatase activity
HUT08_RS05815	COG1535	isochorismatase
HUT08_RS05820	COG3433	isochorismatase activity
HUT08_RS05820	COG1535	isochorismatase
HUT08_RS05825	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT08_RS05830	COG1169	isochorismate synthase
HUT08_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS05840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT08_RS05845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS05850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS05855	COG1120	ATPase activity
HUT08_RS05860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT08_RS05865	COG0569	domain protein
HUT08_RS05875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT08_RS05880	COG2362	D-Aminopeptidase
HUT08_RS05885	COG2409	Drug exporters of the RND superfamily
HUT08_RS05890	COG2226	methyltransferase
HUT08_RS05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS05965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS05970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS05985	COG1799	cell septum assembly
HUT08_RS05990	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS05995	COG0477	Major facilitator Superfamily
HUT08_RS06000	COG0671	phosphoesterase, PA-phosphatase related
HUT08_RS06010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT08_RS06030	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS06045	COG1160	GTP binding
HUT08_RS06050	COG0204	Acyl-transferase
HUT08_RS06055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT08_RS06075	COG1187	pseudouridine synthase activity
HUT08_RS06080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT08_RS06085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUT08_RS06100	COG0686	Belongs to the AlaDH PNT family
HUT08_RS06110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS06115	COG1959	2 iron, 2 sulfur cluster binding
HUT08_RS06125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT08_RS06135	COG0494	nUDIX hydrolase
HUT08_RS06140	COG0504	CTP synthase activity
HUT08_RS06145	COG3387	PFAM Glycoside hydrolase 15-related
HUT08_RS06160	COG0497	DNA recombination
HUT08_RS06165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT08_RS06180	COG1120	ATPase activity
HUT08_RS06185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS06190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS06205	COG0647	UMP catabolic process
HUT08_RS06215	COG1309	transcriptional regulator
HUT08_RS06260	COG2094	Belongs to the DNA glycosylase MPG family
HUT08_RS06275	COG1881	PFAM PEBP family protein
HUT08_RS06295	COG1119	ATPase activity
HUT08_RS06310	COG2197	response regulator
HUT08_RS06330	COG1716	ATPase activity
HUT08_RS06330	COG0842	Transport permease protein
HUT08_RS06330	COG1131	(ABC) transporter
HUT08_RS06335	COG3830	Belongs to the UPF0237 family
HUT08_RS06335	COG0560	Phosphoserine phosphatase
HUT08_RS06350	COG2807	transmembrane transport
HUT08_RS06355	COG2186	Transcriptional regulator
HUT08_RS06365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUT08_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS06385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT08_RS06405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT08_RS06410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT08_RS06435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT08_RS06445	COG3387	PFAM Glycoside hydrolase 15-related
HUT08_RS06475	COG1302	Protein conserved in bacteria
HUT08_RS06495	COG0488	(ABC) transporter
HUT08_RS06525	COG0235	Class ii aldolase
HUT08_RS06540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUT08_RS06560	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT08_RS06595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS06600	COG1917	Cupin 2, conserved barrel domain protein
HUT08_RS06605	COG5285	phytanoyl-CoA dioxygenase
HUT08_RS06610	COG1104	cysteine desulfurase activity
HUT08_RS06620	COG1309	transcriptional regulator
HUT08_RS06645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS06665	COG2171	N-acyltransferase activity
HUT08_RS06670	COG3226	Transcriptional regulator
HUT08_RS06675	COG2076	Multidrug Resistance protein
HUT08_RS06680	COG2318	DinB family
HUT08_RS06685	COG1252	NADH dehydrogenase
HUT08_RS06700	COG0822	iron-sulfur transferase activity
HUT08_RS06705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT08_RS06710	COG0396	ATPase activity
HUT08_RS06735	COG1131	(ABC) transporter
HUT08_RS06745	COG1612	heme a metabolic process
HUT08_RS06760	COG0109	protoheme IX farnesyltransferase activity
HUT08_RS06770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT08_RS06785	COG0363	glucosamine-6-phosphate deaminase activity
HUT08_RS06790	COG0166	Belongs to the GPI family
HUT08_RS06800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT08_RS06805	COG0149	triose-phosphate isomerase activity
HUT08_RS06810	COG0126	phosphoglycerate kinase activity
HUT08_RS06815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT08_RS06820	COG1481	regulation of sporulation
HUT08_RS06825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT08_RS06830	COG1660	Displays ATPase and GTPase activities
HUT08_RS06835	COG0322	excinuclease ABC activity
HUT08_RS06875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT08_RS06905	COG0556	nucleotide-excision repair
HUT08_RS06920	COG0584	glycerophosphoryl diester phosphodiesterase
HUT08_RS06925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT08_RS06960	COG0237	dephospho-CoA kinase activity
HUT08_RS06980	COG2226	methyltransferase
HUT08_RS07005	COG2050	protein possibly involved in aromatic compounds catabolism
HUT08_RS07030	COG0737	Belongs to the 5'-nucleotidase family
HUT08_RS07050	COG0702	epimerase
HUT08_RS07065	COG0287	Prephenate dehydrogenase
HUT08_RS07065	COG1605	Chorismate mutase
HUT08_RS07085	COG0596	Alpha beta hydrolase
HUT08_RS07095	COG1470	cell adhesion involved in biofilm formation
HUT08_RS07095	COG0366	Alpha amylase catalytic
HUT08_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS07110	COG0028	Belongs to the TPP enzyme family
HUT08_RS07140	COG2267	carboxylic ester hydrolase activity
HUT08_RS07155	COG3842	ATPase activity
HUT08_RS07160	COG1725	Transcriptional regulator
HUT08_RS07185	COG0070	glutamate synthase
HUT08_RS07185	COG0067	glutamate synthase
HUT08_RS07185	COG0069	glutamate synthase activity
HUT08_RS07195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT08_RS07215	COG0159	tryptophan synthase activity
HUT08_RS07220	COG0133	tryptophan synthase activity
HUT08_RS07230	COG0134	indole-3-glycerol-phosphate synthase activity
HUT08_RS07260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT08_RS07285	COG0107	imidazoleglycerol-phosphate synthase activity
HUT08_RS07290	COG0251	oxidation-reduction process
HUT08_RS07295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT08_RS07300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT08_RS07310	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT08_RS07315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT08_RS07320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT08_RS07330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT08_RS07335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUT08_RS07355	COG1432	Conserved Protein
HUT08_RS07365	COG0587	DNA-directed DNA polymerase activity
HUT08_RS07415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT08_RS07425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT08_RS07430	COG3599	regulation of cell shape
HUT08_RS07440	COG1799	cell septum assembly
HUT08_RS07455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT08_RS07460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUT08_RS07465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT08_RS07475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT08_RS07480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT08_RS07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUT08_RS07490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT08_RS07495	COG0768	penicillin binding
HUT08_RS07505	COG0275	rRNA processing
HUT08_RS07515	COG0714	Associated with various cellular activities
HUT08_RS07535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT08_RS07545	COG1129	ABC transporter
HUT08_RS07550	COG1511	domain protein
HUT08_RS07555	COG1309	transcriptional regulator
HUT08_RS07575	COG0352	thiamine-phosphate diphosphorylase activity
HUT08_RS07590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT08_RS07590	COG2022	thiamine diphosphate biosynthetic process
HUT08_RS07600	COG2022	thiamine diphosphate biosynthetic process
HUT08_RS07605	COG0515	serine threonine protein kinase
HUT08_RS07605	COG2815	serine threonine protein kinase
HUT08_RS07610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT08_RS07615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT08_RS07620	COG2193	ferroxidase activity
HUT08_RS07625	COG0243	molybdopterin cofactor binding
HUT08_RS07630	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT08_RS07640	COG0205	6-phosphofructokinase activity
HUT08_RS07645	COG2197	response regulator
HUT08_RS07650	COG4585	Histidine kinase
HUT08_RS07675	COG1940	carbohydrate kinase activity
HUT08_RS07685	COG0003	Pfam Anion-transporting ATPase
HUT08_RS07720	COG0791	NLP P60 protein
HUT08_RS07735	COG0705	Rhomboid family
HUT08_RS07750	COG2205	protein histidine kinase activity
HUT08_RS07755	COG0745	RESPONSE REGULATOR receiver
HUT08_RS07765	COG1929	Belongs to the glycerate kinase type-1 family
HUT08_RS07770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT08_RS07775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT08_RS07780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT08_RS07785	COG0723	plastoquinol--plastocyanin reductase activity
HUT08_RS07790	COG2010	Cytochrome c
HUT08_RS07795	COG1845	cytochrome c oxidase, subunit III
HUT08_RS07805	COG1376	ErfK ybiS ycfS ynhG family protein
HUT08_RS07815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT08_RS07820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT08_RS07835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT08_RS07855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT08_RS07860	COG2197	response regulator
HUT08_RS07865	COG4585	Histidine kinase
HUT08_RS07885	COG2226	methyltransferase
HUT08_RS07890	COG1132	(ABC) transporter
HUT08_RS07895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT08_RS07910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT08_RS07915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT08_RS07915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUT08_RS07930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT08_RS07935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT08_RS07940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT08_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT08_RS07955	COG4585	Histidine kinase
HUT08_RS07960	COG2197	response regulator
HUT08_RS07965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT08_RS07990	COG1090	epimerase
HUT08_RS08005	COG0321	lipoyl(octanoyl) transferase activity
HUT08_RS08010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT08_RS08100	COG4974	Belongs to the 'phage' integrase family
HUT08_RS08125	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS08155	COG1120	ATPase activity
HUT08_RS08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS08170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS08180	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS08225	COG0745	RESPONSE REGULATOR receiver
HUT08_RS08250	COG2197	response regulator
HUT08_RS08275	COG1309	transcriptional regulator
HUT08_RS08290	COG0366	Alpha amylase catalytic
HUT08_RS08295	COG1609	Transcriptional regulator
HUT08_RS08305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT08_RS08315	COG0174	glutamine synthetase
HUT08_RS08320	COG3291	Pkd domain containing protein
HUT08_RS08325	COG1802	Transcriptional regulator
HUT08_RS08335	COG2132	Multicopper oxidase
HUT08_RS08350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT08_RS08350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT08_RS08395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT08_RS08405	COG1309	transcriptional regulator
HUT08_RS08410	COG0477	Major facilitator Superfamily
HUT08_RS08415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT08_RS08420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS08440	COG1994	Peptidase M50
HUT08_RS08455	COG0395	ABC-type sugar transport system, permease component
HUT08_RS08460	COG1175	transmembrane transport
HUT08_RS08510	COG5398	heme oxygenase
HUT08_RS08525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT08_RS08530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS08535	COG1120	ATPase activity
HUT08_RS08550	COG1309	transcriptional regulator
HUT08_RS08560	COG1834	amidinotransferase
HUT08_RS08570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT08_RS08575	COG2814	Major facilitator Superfamily
HUT08_RS08585	COG3540	Alkaline phosphatase
HUT08_RS08590	COG0384	phenazine biosynthesis protein PhzF
HUT08_RS08625	COG2409	Drug exporters of the RND superfamily
HUT08_RS08640	COG0529	Catalyzes the synthesis of activated sulfate
HUT08_RS08660	COG1116	anion transmembrane transporter activity
HUT08_RS08665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT08_RS08675	COG3022	response to hydroperoxide
HUT08_RS08680	COG0800	Aldolase
HUT08_RS08695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT08_RS08700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT08_RS08710	COG1131	(ABC) transporter
HUT08_RS08720	COG4585	Histidine kinase
HUT08_RS08745	COG4106	trans-aconitate 2-methyltransferase activity
HUT08_RS08750	COG2197	response regulator
HUT08_RS08795	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS08800	COG1309	transcriptional regulator
HUT08_RS08830	COG3845	ABC transporter
HUT08_RS08845	COG0183	Belongs to the thiolase family
HUT08_RS08870	COG2409	Drug exporters of the RND superfamily
HUT08_RS08955	COG2259	Doxx family
HUT08_RS08965	COG0739	heme binding
HUT08_RS08965	COG0741	lytic transglycosylase activity
HUT08_RS08965	COG1196	nuclear chromosome segregation
HUT08_RS08990	COG0583	DNA-binding transcription factor activity
HUT08_RS09015	COG2188	Transcriptional regulator
HUT08_RS09025	COG2197	response regulator
HUT08_RS09040	COG0586	Pfam SNARE associated Golgi protein
HUT08_RS09050	COG1358	cellular component organization or biogenesis
HUT08_RS09095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT08_RS09105	COG0477	Major facilitator Superfamily
HUT08_RS09110	COG1309	transcriptional regulator
HUT08_RS09125	COG4585	Histidine kinase
HUT08_RS09130	COG2197	response regulator
HUT08_RS09145	COG0667	Aldo Keto reductase
HUT08_RS09150	COG0789	Transcriptional regulator
HUT08_RS09175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT08_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS09185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS09205	COG1764	response to oxidative stress
HUT08_RS09210	COG2130	NADP-dependent
HUT08_RS09220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT08_RS09225	COG0076	glutamate decarboxylase activity
HUT08_RS09245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS09250	COG0583	DNA-binding transcription factor activity
HUT08_RS09260	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT08_RS09265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT08_RS09280	COG1045	serine acetyltransferase
HUT08_RS09285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT08_RS09295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS09310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS09315	COG1309	transcriptional regulator
HUT08_RS09325	COG0588	phosphoglycerate mutase activity
HUT08_RS09330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT08_RS09335	COG0583	DNA-binding transcription factor activity
HUT08_RS09345	COG2030	dehydratase
HUT08_RS09355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT08_RS09380	COG2409	Drug exporters of the RND superfamily
HUT08_RS09405	COG2267	carboxylic ester hydrolase activity
HUT08_RS09415	COG3629	intracellular signal transduction
HUT08_RS09415	COG3903	Transcriptional regulator
HUT08_RS09430	COG0702	epimerase
HUT08_RS09490	COG4115	mRNA cleavage
HUT08_RS09515	COG1070	Carbohydrate kinase
HUT08_RS09525	COG0358	DNA primase activity
HUT08_RS09530	COG2153	protein acetylation
HUT08_RS09540	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT08_RS09550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT08_RS09560	COG1324	tolerance protein
HUT08_RS09590	COG0702	epimerase
HUT08_RS09675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT08_RS09675	COG0574	Belongs to the PEP-utilizing enzyme family
HUT08_RS09690	COG0477	Major facilitator Superfamily
HUT08_RS09695	COG0423	glycine-tRNA ligase activity
HUT08_RS09700	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT08_RS09700	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT08_RS09705	COG1121	(ABC) transporter
HUT08_RS09710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT08_RS09725	COG2186	Transcriptional regulator
HUT08_RS09730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT08_RS09735	COG1381	Involved in DNA repair and RecF pathway recombination
HUT08_RS09755	COG2197	response regulator
HUT08_RS09760	COG4585	Histidine kinase
HUT08_RS09765	COG2409	Drug exporters of the RND superfamily
HUT08_RS09775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT08_RS09795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT08_RS09820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT08_RS09820	COG1672	PFAM Archaeal ATPase
HUT08_RS09830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT08_RS09840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT08_RS09855	COG1234	tRNA 3'-trailer cleavage
HUT08_RS09860	COG0537	adenosine 5'-monophosphoramidase activity
HUT08_RS09880	COG0484	heat shock protein binding
HUT08_RS09885	COG1420	regulation of RNA biosynthetic process
HUT08_RS09915	COG1022	Amp-dependent synthetase and ligase
HUT08_RS09920	COG0481	GTPase activity
HUT08_RS09925	COG0268	Binds directly to 16S ribosomal RNA
HUT08_RS09960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUT08_RS10035	COG1555	photosystem II stabilization
HUT08_RS10045	COG1307	EDD domain protein, DegV family
HUT08_RS10055	COG0495	leucyl-tRNA aminoacylation
HUT08_RS10065	COG2205	protein histidine kinase activity
HUT08_RS10070	COG0745	RESPONSE REGULATOR receiver
HUT08_RS10080	COG1136	(ABC) transporter
HUT08_RS10080	COG0577	efflux transmembrane transporter activity
HUT08_RS10085	COG1136	(ABC) transporter
HUT08_RS10085	COG0577	efflux transmembrane transporter activity
HUT08_RS10110	COG0588	phosphoglycerate mutase activity
HUT08_RS10115	COG0799	negative regulation of ribosome biogenesis
HUT08_RS10125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT08_RS10140	COG0501	Belongs to the peptidase M48B family
HUT08_RS10155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT08_RS10165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT08_RS10175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT08_RS10180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT08_RS10185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT08_RS10190	COG1530	ribonuclease E activity
HUT08_RS10200	COG0515	serine threonine protein kinase
HUT08_RS10200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS10230	COG0772	Belongs to the SEDS family
HUT08_RS10235	COG0768	penicillin binding
HUT08_RS10250	COG1077	Cell shape determining protein MreB Mrl
HUT08_RS10255	COG0105	UTP biosynthetic process
HUT08_RS10265	COG0285	dihydrofolate synthase activity
HUT08_RS10270	COG0525	valine-tRNA ligase activity
HUT08_RS10285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT08_RS10290	COG0740	serine-type endopeptidase activity
HUT08_RS10295	COG0740	serine-type endopeptidase activity
HUT08_RS10300	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT08_RS10335	COG1136	(ABC) transporter
HUT08_RS10340	COG0475	glutathione-regulated potassium exporter activity
HUT08_RS10360	COG1113	amino acid transport
HUT08_RS10365	COG1268	BioY protein
HUT08_RS10370	COG1113	amino acid transport
HUT08_RS10375	COG1113	amino acid transport
HUT08_RS10380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUT08_RS10425	COG4266	Belongs to the allantoicase family
HUT08_RS10455	COG0668	transmembrane transport
HUT08_RS10460	COG1940	carbohydrate kinase activity
HUT08_RS10460	COG1846	Transcriptional regulator
HUT08_RS10470	COG1175	transmembrane transport
HUT08_RS10475	COG0395	ABC-type sugar transport system, permease component
HUT08_RS10480	COG1486	melibiose metabolic process
HUT08_RS10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT08_RS10530	COG2304	oxidoreductase activity
HUT08_RS10555	COG1136	(ABC) transporter
HUT08_RS10555	COG0577	efflux transmembrane transporter activity
HUT08_RS10585	COG0629	single-stranded DNA binding
HUT08_RS10590	COG0477	Major facilitator Superfamily
HUT08_RS10595	COG3629	intracellular signal transduction
HUT08_RS10595	COG3903	Transcriptional regulator
HUT08_RS10625	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUT08_RS10640	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS10645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT08_RS10650	COG3961	Belongs to the TPP enzyme family
HUT08_RS10695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT08_RS10710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT08_RS10715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS10725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT08_RS10795	COG4221	oxidoreductase activity
HUT08_RS10890	COG4977	sequence-specific DNA binding
HUT08_RS10915	COG2197	response regulator
HUT08_RS10920	COG4585	Histidine kinase
HUT08_RS10940	COG1140	nitrate reductase beta subunit
HUT08_RS10945	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HUT08_RS10955	COG1309	transcriptional regulator
HUT08_RS10965	COG1902	pentaerythritol trinitrate reductase activity
HUT08_RS10980	COG0640	Transcriptional regulator
HUT08_RS10995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS11000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT08_RS11025	COG0723	plastoquinol--plastocyanin reductase activity
HUT08_RS11040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT08_RS11040	COG1672	PFAM Archaeal ATPase
HUT08_RS11060	COG0583	DNA-binding transcription factor activity
HUT08_RS11070	COG1053	succinate dehydrogenase
HUT08_RS11075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT08_RS11190	COG3962	Belongs to the TPP enzyme family
HUT08_RS11195	COG3718	enzyme involved in inositol metabolism
HUT08_RS11205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT08_RS11215	COG0673	inositol 2-dehydrogenase activity
HUT08_RS11255	COG1609	Transcriptional regulator
HUT08_RS11265	COG0697	spore germination
HUT08_RS11270	COG0583	DNA-binding transcription factor activity
HUT08_RS11325	COG1946	Acyl-CoA thioesterase
HUT08_RS11335	COG1309	transcriptional regulator
HUT08_RS11340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT08_RS11355	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS11370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT08_RS11375	COG0589	response to stress
HUT08_RS11380	COG4977	sequence-specific DNA binding
HUT08_RS11385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT08_RS11415	COG2207	Transcriptional regulator
HUT08_RS11435	COG0406	alpha-ribazole phosphatase activity
HUT08_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS11500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS11520	COG0154	amidase activity
HUT08_RS11535	COG0765	amino acid transport
HUT08_RS11540	COG0765	amino acid transport
HUT08_RS11545	COG1126	abc transporter atp-binding protein
HUT08_RS11560	COG3397	chitin binding
HUT08_RS11590	COG2186	Transcriptional regulator
HUT08_RS11610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS11655	COG2188	Transcriptional regulator
HUT08_RS11675	COG0673	inositol 2-dehydrogenase activity
HUT08_RS11680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT08_RS11730	COG2733	membrane
HUT08_RS11745	COG4555	ABC transporter
HUT08_RS11760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT08_RS11770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT08_RS11800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT08_RS11810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT08_RS11815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUT08_RS11820	COG1263	PTS System
HUT08_RS11825	COG1263	PTS System
HUT08_RS11830	COG1234	tRNA 3'-trailer cleavage
HUT08_RS11860	COG1113	amino acid transport
HUT08_RS11870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT08_RS11880	COG1335	isochorismatase
HUT08_RS11935	COG0277	FAD linked oxidase domain protein
HUT08_RS11945	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT08_RS11955	COG1174	glycine betaine transport
HUT08_RS11965	COG1174	glycine betaine transport
HUT08_RS11980	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT08_RS11995	COG3654	unkown
HUT08_RS12005	COG0477	Major facilitator Superfamily
HUT08_RS12010	COG2855	membrane
HUT08_RS12020	COG0583	DNA-binding transcription factor activity
HUT08_RS12055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS12055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS12075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT08_RS12090	COG0395	ABC-type sugar transport system, permease component
HUT08_RS12095	COG1175	transmembrane transport
HUT08_RS12115	COG2814	Major facilitator Superfamily
HUT08_RS12120	COG0583	DNA-binding transcription factor activity
HUT08_RS12130	COG1678	Uncharacterized ACR, COG1678
HUT08_RS12135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT08_RS12140	COG0776	regulation of translation
HUT08_RS12150	COG3973	AAA domain
HUT08_RS12150	COG3973	AAA domain
HUT08_RS12175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT08_RS12180	COG0793	Belongs to the peptidase S41A family
HUT08_RS12195	COG2884	Cell division ATP-binding protein ftsE
HUT08_RS12210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT08_RS12215	COG0515	serine threonine protein kinase
HUT08_RS12220	COG0515	serine threonine protein kinase
HUT08_RS12230	COG1653	transport
HUT08_RS12235	COG1175	transmembrane transport
HUT08_RS12240	COG0395	ABC-type sugar transport system, permease component
HUT08_RS12250	COG1595	DNA-templated transcription, initiation
HUT08_RS12280	COG0653	protein targeting
HUT08_RS12285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT08_RS12290	COG3214	Protein conserved in bacteria
HUT08_RS12295	COG2197	response regulator
HUT08_RS12300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT08_RS12310	COG0823	Involved in the tonB-independent uptake of proteins
HUT08_RS12315	COG5002	protein histidine kinase activity
HUT08_RS12320	COG0745	RESPONSE REGULATOR receiver
HUT08_RS12325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT08_RS12350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT08_RS12355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT08_RS12355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUT08_RS12355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUT08_RS12365	COG1482	cell wall glycoprotein biosynthetic process
HUT08_RS12375	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT08_RS12380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT08_RS12385	COG1620	l-lactate permease
HUT08_RS12425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT08_RS12430	COG0778	Nitroreductase
HUT08_RS12430	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT08_RS12455	COG1316	TRANSCRIPTIONal
HUT08_RS12460	COG1316	TRANSCRIPTIONal
HUT08_RS12480	COG1316	TRANSCRIPTIONal
HUT08_RS12495	COG1316	TRANSCRIPTIONal
HUT08_RS12515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT08_RS12520	COG2197	response regulator
HUT08_RS12535	COG1131	(ABC) transporter
HUT08_RS12590	COG2205	protein histidine kinase activity
HUT08_RS12595	COG0745	RESPONSE REGULATOR receiver
HUT08_RS12600	COG3104	oligopeptide transport
HUT08_RS12610	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT08_RS12615	COG1191	sigma factor activity
HUT08_RS12620	COG1309	transcriptional regulator
HUT08_RS12645	COG1228	amidohydrolase
HUT08_RS12660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT08_RS12665	COG2264	protein methyltransferase activity
HUT08_RS12675	COG2814	Major facilitator Superfamily
HUT08_RS12680	COG3938	Belongs to the proline racemase family
HUT08_RS12690	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT08_RS12705	COG1476	TRANSCRIPTIONal
HUT08_RS12755	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS12780	COG0148	phosphopyruvate hydratase activity
HUT08_RS12790	COG2755	lipolytic protein G-D-S-L family
HUT08_RS12795	COG0183	Belongs to the thiolase family
HUT08_RS12835	COG0583	DNA-binding transcription factor activity
HUT08_RS12850	COG1136	(ABC) transporter
HUT08_RS12855	COG0577	efflux transmembrane transporter activity
HUT08_RS12860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT08_RS12905	COG4977	sequence-specific DNA binding
HUT08_RS12930	COG0148	phosphopyruvate hydratase activity
HUT08_RS12945	COG2124	cytochrome p450
HUT08_RS12955	COG2814	Major facilitator Superfamily
HUT08_RS13005	COG2986	histidine ammonia-lyase
HUT08_RS13020	COG1024	Enoyl-CoA hydratase
HUT08_RS13025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT08_RS13035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT08_RS13045	COG0424	maF-like protein
HUT08_RS13055	COG4770	biotin carboxylase activity
HUT08_RS13085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT08_RS13100	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS13105	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS13115	COG1595	DNA-templated transcription, initiation
HUT08_RS13120	COG0745	RESPONSE REGULATOR receiver
HUT08_RS13125	COG2205	protein histidine kinase activity
HUT08_RS13150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT08_RS13165	COG0583	DNA-binding transcription factor activity
HUT08_RS13170	COG2814	Major facilitator Superfamily
HUT08_RS13190	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUT08_RS13195	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUT08_RS13200	COG3845	ABC transporter
HUT08_RS13205	COG1744	ABC transporter substrate-binding protein PnrA-like
HUT08_RS13210	COG1473	amidohydrolase
HUT08_RS13210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT08_RS13220	COG2089	acid synthase
HUT08_RS13235	COG1216	Glycosyl transferase, family 2
HUT08_RS13245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT08_RS13275	COG3265	gluconokinase activity
HUT08_RS13280	COG2186	Transcriptional regulator
HUT08_RS13285	COG2226	methyltransferase
HUT08_RS13310	COG1595	DNA-templated transcription, initiation
HUT08_RS13330	COG2009	succinate dehydrogenase
HUT08_RS13340	COG1053	succinate dehydrogenase
HUT08_RS13345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT08_RS13365	COG1408	metallophosphoesterase
HUT08_RS13385	COG1295	ribonuclease BN
HUT08_RS13390	COG3973	AAA domain
HUT08_RS13405	COG0180	Tryptophanyl-tRNA synthetase
HUT08_RS13410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT08_RS13415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS13420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS13435	COG4176	ABC-type proline glycine betaine transport system permease component
HUT08_RS13450	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS13465	COG0039	L-malate dehydrogenase activity
HUT08_RS13480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT08_RS13485	COG0138	bifunctional purine biosynthesis protein purh
HUT08_RS13525	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT08_RS13530	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT08_RS13545	COG0714	Associated with various cellular activities
HUT08_RS13560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS13560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS13580	COG1959	2 iron, 2 sulfur cluster binding
HUT08_RS13590	COG0726	polysaccharide deacetylase
HUT08_RS13595	COG2197	response regulator
HUT08_RS13640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT08_RS13640	COG0519	Catalyzes the synthesis of GMP from XMP
HUT08_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS13665	COG2815	serine threonine protein kinase
HUT08_RS13665	COG0515	serine threonine protein kinase
HUT08_RS13755	COG1131	(ABC) transporter
HUT08_RS13880	COG1674	ftsk spoiiie
HUT08_RS13890	COG2945	thiolester hydrolase activity
HUT08_RS13890	COG0596	Alpha beta hydrolase
HUT08_RS13900	COG4821	SIS domain
HUT08_RS13915	COG0259	pyridoxamine-phosphate oxidase activity
HUT08_RS13935	COG1309	transcriptional regulator
HUT08_RS14035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT08_RS14065	COG0277	FAD linked oxidase domain protein
HUT08_RS14065	COG0247	lactate metabolic process
HUT08_RS14095	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT08_RS14115	COG0640	Transcriptional regulator
HUT08_RS14120	COG0477	Major facilitator Superfamily
HUT08_RS14125	COG0384	phenazine biosynthesis protein PhzF
HUT08_RS14180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS14185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS14190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT08_RS14210	COG0667	Aldo Keto reductase
HUT08_RS14250	COG2252	PERMEase
HUT08_RS14260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT08_RS14290	COG2814	Major facilitator Superfamily
HUT08_RS14300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT08_RS14305	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT08_RS14320	COG1278	Cold shock
HUT08_RS14335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS14340	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS14345	COG1120	ATPase activity
HUT08_RS14375	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT08_RS14410	COG1061	Type III restriction enzyme res subunit
HUT08_RS14420	COG3973	AAA domain
HUT08_RS14440	COG0456	acetyltransferase
HUT08_RS14445	COG3142	Participates in the control of copper homeostasis
HUT08_RS14470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT08_RS14475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT08_RS14480	COG0459	protein refolding
HUT08_RS14485	COG1278	Cold shock
HUT08_RS14495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT08_RS14500	COG0463	Glycosyl transferase, family 2
HUT08_RS14510	COG0561	phosphatase activity
HUT08_RS14510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT08_RS14535	COG1105	Belongs to the carbohydrate kinase PfkB family
HUT08_RS14555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT08_RS14560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT08_RS14600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUT08_RS14610	COG0789	Transcriptional regulator
HUT08_RS14625	COG1846	Transcriptional regulator
HUT08_RS14650	COG0640	Transcriptional regulator
HUT08_RS14655	COG0477	Major facilitator Superfamily
HUT08_RS14665	COG0477	Major facilitator Superfamily
HUT08_RS14675	COG1733	regulation of RNA biosynthetic process
HUT08_RS14715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT08_RS14720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT08_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS14785	COG3842	ATPase activity
HUT08_RS14795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUT08_RS14805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT08_RS14810	COG0215	cysteine-tRNA ligase activity
HUT08_RS14820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT08_RS14825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT08_RS14830	COG1329	Transcriptional regulator
HUT08_RS14845	COG5002	protein histidine kinase activity
HUT08_RS14855	COG1846	Transcriptional regulator
HUT08_RS14875	COG0588	phosphoglycerate mutase activity
HUT08_RS14900	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS14915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT08_RS14955	COG0494	nUDIX hydrolase
HUT08_RS14955	COG0406	alpha-ribazole phosphatase activity
HUT08_RS14965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT08_RS14970	COG0456	acetyltransferase
HUT08_RS14975	COG0737	Belongs to the 5'-nucleotidase family
HUT08_RS14980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT08_RS15005	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT08_RS15010	COG2259	Doxx family
HUT08_RS15025	COG1309	transcriptional regulator
HUT08_RS15035	COG2205	protein histidine kinase activity
HUT08_RS15045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT08_RS15050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS15070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS15075	COG1609	Transcriptional regulator
HUT08_RS15080	COG0745	RESPONSE REGULATOR receiver
HUT08_RS15090	COG0789	Transcriptional regulator
HUT08_RS15120	COG2897	thiosulfate sulfurtransferase activity
HUT08_RS15140	COG3485	protocatechuate 3,4-dioxygenase
HUT08_RS15145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS15150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT08_RS15160	COG0735	belongs to the Fur family
HUT08_RS15165	COG0354	folic acid binding
HUT08_RS15175	COG1192	Involved in chromosome partitioning
HUT08_RS15180	COG1490	D-aminoacyl-tRNA deacylase activity
HUT08_RS15195	COG4552	Acetyltransferase involved in intracellular survival and related
HUT08_RS15210	COG2084	Dehydrogenase
HUT08_RS15215	COG1733	regulation of RNA biosynthetic process
HUT08_RS15220	COG2378	regulation of single-species biofilm formation
HUT08_RS15240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT08_RS15260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT08_RS15270	COG1902	pentaerythritol trinitrate reductase activity
HUT08_RS15275	COG1595	DNA-templated transcription, initiation
HUT08_RS15295	COG4977	sequence-specific DNA binding
HUT08_RS15315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT08_RS15400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT08_RS15405	COG0306	phosphate transporter
HUT08_RS15415	COG1937	Protein conserved in bacteria
HUT08_RS15430	COG0277	FAD linked oxidase domain protein
HUT08_RS15435	COG0671	phosphoesterase, PA-phosphatase related
HUT08_RS15440	COG0739	heme binding
HUT08_RS15440	COG0741	lytic transglycosylase activity
HUT08_RS15440	COG1196	nuclear chromosome segregation
HUT08_RS15500	COG0180	Tryptophanyl-tRNA synthetase
HUT08_RS15505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUT08_RS15510	COG2409	Drug exporters of the RND superfamily
HUT08_RS15610	COG0129	dihydroxy-acid dehydratase activity
HUT08_RS15620	COG1082	Xylose isomerase domain protein TIM barrel
HUT08_RS15625	COG0248	Ppx GppA phosphatase
HUT08_RS15655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT08_RS15665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT08_RS15690	COG0745	RESPONSE REGULATOR receiver
HUT08_RS15695	COG2205	protein histidine kinase activity
HUT08_RS15725	COG0739	heme binding
HUT08_RS15755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT08_RS15775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT08_RS15785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT08_RS15790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT08_RS15810	COG2197	response regulator
HUT08_RS15825	COG0649	NAD binding
HUT08_RS15835	COG1732	Glycine betaine
HUT08_RS15850	COG1125	glycine betaine transport
HUT08_RS15850	COG0517	IMP dehydrogenase activity
HUT08_RS15860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUT08_RS15865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT08_RS15890	COG0302	gtp cyclohydrolase
HUT08_RS15905	COG0037	tRNA processing
HUT08_RS15915	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT08_RS15920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT08_RS15935	COG0393	Putative heavy-metal-binding
HUT08_RS15940	COG0789	Transcriptional regulator
HUT08_RS15965	COG0181	hydroxymethylbilane synthase activity
HUT08_RS15975	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT08_RS16000	COG2318	DinB family
HUT08_RS16005	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS16025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT08_RS16035	COG0254	rRNA binding
HUT08_RS16040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT08_RS16045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT08_RS16055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT08_RS16055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT08_RS16060	COG1077	Cell shape determining protein MreB Mrl
HUT08_RS16080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS16095	COG4770	biotin carboxylase activity
HUT08_RS16105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT08_RS16110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUT08_RS16115	COG0477	Major facilitator Superfamily
HUT08_RS16130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS16135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUT08_RS16170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS16185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS16195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUT08_RS16215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT08_RS16220	COG1733	regulation of RNA biosynthetic process
HUT08_RS16235	COG1595	DNA-templated transcription, initiation
HUT08_RS16240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS16245	COG2318	DinB family
HUT08_RS16280	COG0436	Aminotransferase
HUT08_RS16285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT08_RS16290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT08_RS16295	COG2197	response regulator
HUT08_RS16300	COG4585	Histidine kinase
HUT08_RS16305	COG2409	Drug exporters of the RND superfamily
HUT08_RS16310	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT08_RS16325	COG0019	diaminopimelate decarboxylase activity
HUT08_RS16355	COG0494	nUDIX hydrolase
HUT08_RS16365	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HUT08_RS16375	COG0406	alpha-ribazole phosphatase activity
HUT08_RS16380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT08_RS16465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT08_RS16470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT08_RS16475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT08_RS16475	COG1754	DNA topoisomerase type I activity
HUT08_RS16485	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT08_RS16495	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT08_RS16505	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT08_RS16510	COG1205	dead DEAH box helicase
HUT08_RS16510	COG1111	helicase
HUT08_RS16575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT08_RS16580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT08_RS16590	COG0596	Alpha beta hydrolase
HUT08_RS16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT08_RS16655	COG0003	Pfam Anion-transporting ATPase
HUT08_RS16665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT08_RS16675	COG1408	metallophosphoesterase
HUT08_RS16710	COG1609	Transcriptional regulator
HUT08_RS16765	COG0017	Asparaginyl-tRNA synthetase
HUT08_RS16805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT08_RS16820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT08_RS16835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUT08_RS16845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUT08_RS16900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS16905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUT08_RS16925	COG1595	DNA-templated transcription, initiation
HUT08_RS16950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT08_RS16955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT08_RS17065	COG1725	Transcriptional regulator
HUT08_RS17070	COG0590	tRNA wobble adenosine to inosine editing
HUT08_RS17080	COG2318	DinB family
HUT08_RS17115	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HUT08_RS17160	COG0076	glutamate decarboxylase activity
HUT08_RS17175	COG0488	(ABC) transporter
HUT08_RS17195	COG0402	S-adenosylhomocysteine deaminase activity
HUT08_RS17230	COG0535	radical SAM domain protein
HUT08_RS17255	COG2362	D-Aminopeptidase
HUT08_RS17290	COG2084	Dehydrogenase
HUT08_RS17330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT08_RS17360	COG0531	amino acid
HUT08_RS17410	COG0697	spore germination
HUT08_RS17435	COG2409	Drug exporters of the RND superfamily
HUT08_RS17445	COG2197	response regulator
HUT08_RS17465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT08_RS17485	COG3896	Chloramphenicol phosphotransferase-like protein
HUT08_RS17490	COG2226	methyltransferase
HUT08_RS17530	COG1191	sigma factor activity
HUT08_RS17535	COG1191	sigma factor activity
HUT08_RS17555	COG2353	YceI-like domain
HUT08_RS17565	COG0477	Major facilitator Superfamily
HUT08_RS17570	COG0745	RESPONSE REGULATOR receiver
HUT08_RS17630	COG2188	Transcriptional regulator
HUT08_RS17665	COG0582	viral genome integration into host DNA
HUT08_RS17685	COG0784	Response regulator, receiver
HUT08_RS17700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT08_RS17705	COG0488	(ABC) transporter
HUT08_RS17715	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS17725	COG1595	DNA-templated transcription, initiation
HUT08_RS17745	COG0583	DNA-binding transcription factor activity
HUT08_RS17750	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS17765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT08_RS17780	COG0653	protein targeting
HUT08_RS17795	COG0006	proline dipeptidase activity
HUT08_RS17805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT08_RS17845	COG1999	signal sequence binding
HUT08_RS17855	COG2372	response to copper ion
HUT08_RS17860	COG2837	iron assimilation
HUT08_RS17865	COG0673	inositol 2-dehydrogenase activity
HUT08_RS17875	COG0395	ABC-type sugar transport system, permease component
HUT08_RS17880	COG4209	transmembrane transport
HUT08_RS17900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT08_RS17910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT08_RS17915	COG0561	phosphatase activity
HUT08_RS17945	COG1819	glycosyl
HUT08_RS17970	COG2186	Transcriptional regulator
HUT08_RS17975	COG2807	transmembrane transport
HUT08_RS17990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT08_RS18000	COG1396	sequence-specific DNA binding
HUT08_RS18050	COG0789	Transcriptional regulator
HUT08_RS18065	COG0501	Belongs to the peptidase M48B family
HUT08_RS18085	COG0561	phosphatase activity
HUT08_RS18105	COG4988	ABC transporter
HUT08_RS18110	COG1294	oxidase, subunit
HUT08_RS18115	COG1271	oxidase subunit
HUT08_RS18120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT08_RS18125	COG1609	Transcriptional regulator
HUT08_RS18130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT08_RS18145	COG0504	CTP synthase activity
HUT08_RS18160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT08_RS18185	COG0662	Cupin 2, conserved barrel domain protein
HUT08_RS18190	COG1950	PFAM Membrane protein of
HUT08_RS18195	COG0626	cystathionine gamma-synthase activity
HUT08_RS18230	COG2814	Major facilitator Superfamily
HUT08_RS18315	COG0305	Participates in initiation and elongation during chromosome replication
HUT08_RS18320	COG0534	Mate efflux family protein
HUT08_RS18325	COG0359	binds to the 23S rRNA
HUT08_RS18330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT08_RS18335	COG0629	single-stranded DNA binding
HUT08_RS18340	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT08_RS18365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT08_RS18385	COG0617	tRNA 3'-terminal CCA addition
HUT08_RS18405	COG1595	DNA-templated transcription, initiation
HUT08_RS18415	COG0492	ferredoxin-NADP+ reductase activity
HUT08_RS18420	COG3118	belongs to the thioredoxin family
HUT08_RS18435	COG1192	Involved in chromosome partitioning
HUT08_RS18440	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT08_RS18450	COG0706	membrane insertase activity
HUT08_RS18455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT08_RS18465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT08_RS18475	COG0592	DNA-directed DNA polymerase activity
HUT08_RS18480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT08_RS18485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT08_RS18490	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT08_RS18500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT08_RS18545	COG2205	protein histidine kinase activity
HUT08_RS18550	COG0745	RESPONSE REGULATOR receiver
HUT08_RS18560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUT08_RS18570	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT08_RS18575	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT08_RS18595	COG0705	Rhomboid family
HUT08_RS18620	COG3764	Sortase (surface protein transpeptidase)
HUT08_RS18625	COG3764	Sortase (surface protein transpeptidase)
HUT08_RS18630	COG0515	serine threonine protein kinase
HUT08_RS18635	COG0768	penicillin binding
HUT08_RS18640	COG0772	Belongs to the SEDS family
HUT08_RS18650	COG1716	ATPase activity
HUT08_RS18655	COG1716	ATPase activity
HUT08_RS18665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT08_RS18670	COG1733	regulation of RNA biosynthetic process
HUT08_RS18695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT08_RS18700	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT08_RS18705	COG3396	Phenylacetate-CoA oxygenase
HUT08_RS18710	COG3460	Phenylacetate-CoA oxygenase
HUT08_RS18715	COG3396	Phenylacetate-CoA oxygenase
HUT08_RS18740	COG2076	Multidrug Resistance protein
HUT08_RS18760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS18770	COG1522	sequence-specific DNA binding
HUT08_RS18805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT08_RS18810	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS18810	COG3321	synthase
HUT08_RS18810	COG0604	alcohol dehydrogenase
HUT08_RS18825	COG0515	serine threonine protein kinase
HUT08_RS18830	COG0515	serine threonine protein kinase
HUT08_RS18855	COG0022	dehydrogenase e1 component
HUT08_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT08_RS18930	COG1595	DNA-templated transcription, initiation
HUT08_RS18945	COG3629	intracellular signal transduction
HUT08_RS18945	COG3903	Transcriptional regulator
HUT08_RS18955	COG1362	aminopeptidase activity
HUT08_RS18960	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS18970	COG1741	Belongs to the pirin family
HUT08_RS19000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT08_RS19010	COG1522	sequence-specific DNA binding
HUT08_RS19035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT08_RS19040	COG2304	oxidoreductase activity
HUT08_RS19060	COG2226	methyltransferase
HUT08_RS19065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS19110	COG3285	dna ligase
HUT08_RS19110	COG1793	dna ligase
HUT08_RS19140	COG0583	DNA-binding transcription factor activity
HUT08_RS19200	COG0640	Transcriptional regulator
HUT08_RS19250	COG1595	DNA-templated transcription, initiation
HUT08_RS19260	COG1917	Cupin 2, conserved barrel domain protein
HUT08_RS19260	COG4977	sequence-specific DNA binding
HUT08_RS19375	COG2255	four-way junction helicase activity
HUT08_RS19450	COG1857	crispr-associated protein
HUT08_RS19515	COG1674	ftsk spoiiie
HUT08_RS19610	COG1309	transcriptional regulator
HUT08_RS19615	COG0667	Aldo Keto reductase
HUT08_RS19645	COG2207	Transcriptional regulator
HUT08_RS19655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS19660	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS19665	COG1120	ATPase activity
HUT08_RS19685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT08_RS19695	COG0604	alcohol dehydrogenase
HUT08_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS19730	COG0702	epimerase
HUT08_RS19755	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS19780	COG0717	Belongs to the dCTP deaminase family
HUT08_RS19795	COG4552	Acetyltransferase involved in intracellular survival and related
HUT08_RS19810	COG0247	lactate metabolic process
HUT08_RS19810	COG2181	nitrate reductase activity
HUT08_RS19815	COG0443	Heat shock 70 kDa protein
HUT08_RS19820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT08_RS19825	COG0484	heat shock protein binding
HUT08_RS19830	COG0789	Transcriptional regulator
HUT08_RS19850	COG0542	response to heat
HUT08_RS19875	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUT08_RS19905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT08_RS19910	COG0191	fructose-bisphosphate aldolase activity
HUT08_RS19915	COG0477	Major facilitator Superfamily
HUT08_RS19930	COG3844	kynureninase activity
HUT08_RS19945	COG3559	Exporter of polyketide antibiotics
HUT08_RS19950	COG1131	(ABC) transporter
HUT08_RS19965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT08_RS19975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS19980	COG1802	Transcriptional regulator
HUT08_RS19995	COG0151	Belongs to the GarS family
HUT08_RS20010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT08_RS20035	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT08_RS20040	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT08_RS20045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT08_RS20055	COG3119	arylsulfatase activity
HUT08_RS20065	COG0583	DNA-binding transcription factor activity
HUT08_RS20080	COG1595	DNA-templated transcription, initiation
HUT08_RS20085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS20105	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HUT08_RS20125	COG1051	belongs to the nudix hydrolase family
HUT08_RS20135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT08_RS20145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT08_RS20195	COG1569	PIN domain
HUT08_RS20355	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS20370	COG1215	transferase activity, transferring glycosyl groups
HUT08_RS20405	COG3620	sequence-specific DNA binding
HUT08_RS20525	COG0739	heme binding
HUT08_RS20525	COG0741	lytic transglycosylase activity
HUT08_RS20525	COG1196	nuclear chromosome segregation
HUT08_RS20610	COG1228	amidohydrolase
HUT08_RS20640	COG0582	viral genome integration into host DNA
HUT08_RS20665	COG0513	Belongs to the DEAD box helicase family
HUT08_RS20700	COG1302	Protein conserved in bacteria
HUT08_RS20755	COG0667	Aldo Keto reductase
HUT08_RS20775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUT08_RS20805	COG2197	response regulator
HUT08_RS20840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS20850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT08_RS20860	COG0579	oxidoreductase
HUT08_RS20885	COG0584	glycerophosphoryl diester phosphodiesterase
HUT08_RS20900	COG1252	NADH dehydrogenase
HUT08_RS20920	COG1846	Transcriptional regulator
HUT08_RS20940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT08_RS20945	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUT08_RS20995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT08_RS21000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT08_RS21005	COG0181	hydroxymethylbilane synthase activity
HUT08_RS21010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT08_RS21010	COG1648	precorrin-2 dehydrogenase activity
HUT08_RS21015	COG0113	porphobilinogen synthase activity
HUT08_RS21030	COG2226	methyltransferase
HUT08_RS21060	COG1228	amidohydrolase
HUT08_RS21065	COG1595	DNA-templated transcription, initiation
HUT08_RS21100	COG0018	arginyl-trna synthetase
HUT08_RS21105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT08_RS21130	COG1690	Belongs to the RtcB family
HUT08_RS21140	COG1733	regulation of RNA biosynthetic process
HUT08_RS21155	COG0667	Aldo Keto reductase
HUT08_RS21165	COG1742	UPF0060 membrane protein
HUT08_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS21250	COG0596	Alpha beta hydrolase
HUT08_RS21255	COG3629	intracellular signal transduction
HUT08_RS21255	COG3903	Transcriptional regulator
HUT08_RS21340	COG0243	molybdopterin cofactor binding
HUT08_RS21355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT08_RS21370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT08_RS21375	COG0406	alpha-ribazole phosphatase activity
HUT08_RS21395	COG1333	cytochrome c biogenesis protein
HUT08_RS21400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT08_RS21415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT08_RS21420	COG0109	protoheme IX farnesyltransferase activity
HUT08_RS21425	COG0163	prenyltransferase activity
HUT08_RS21435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT08_RS21440	COG1573	uracil-dna glycosylase
HUT08_RS21455	COG1301	dicarboxylic acid transport
HUT08_RS21460	COG1309	transcriptional regulator
HUT08_RS21470	COG1278	Cold shock
HUT08_RS21475	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT08_RS21485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT08_RS21495	COG2226	methyltransferase
HUT08_RS21680	COG3723	Recombinational DNA repair protein, rece pathway
HUT08_RS21685	COG5377	YqaJ viral recombinase family
HUT08_RS21760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21770	COG0649	NAD binding
HUT08_RS21780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT08_RS21785	COG1034	ATP synthesis coupled electron transport
HUT08_RS21790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT08_RS21795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21800	COG0839	Belongs to the complex I subunit 6 family
HUT08_RS21805	COG0713	ATP synthesis coupled electron transport
HUT08_RS21810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT08_RS21820	COG1007	ATP synthesis coupled electron transport
HUT08_RS21830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT08_RS21835	COG0142	geranyltranstransferase activity
HUT08_RS21860	COG2234	aminopeptidase activity
HUT08_RS21860	COG4935	Belongs to the peptidase S8 family
HUT08_RS21900	COG0702	epimerase
HUT08_RS21905	COG1733	regulation of RNA biosynthetic process
HUT08_RS21910	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT08_RS21915	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT08_RS21915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT08_RS21925	COG4585	Histidine kinase
HUT08_RS21930	COG4585	Histidine kinase
HUT08_RS21935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT08_RS21955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT08_RS21965	COG0713	ATP synthesis coupled electron transport
HUT08_RS21970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT08_RS21980	COG1007	ATP synthesis coupled electron transport
HUT08_RS21985	COG0501	Belongs to the peptidase M48B family
HUT08_RS21990	COG3304	Inner membrane component domain
HUT08_RS22000	COG1666	GTP binding
HUT08_RS22020	COG0702	epimerase
HUT08_RS22030	COG0402	S-adenosylhomocysteine deaminase activity
HUT08_RS22045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT08_RS22050	COG2030	dehydratase
HUT08_RS22070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT08_RS22085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT08_RS22090	COG0436	Aminotransferase
HUT08_RS22105	COG0250	Participates in transcription elongation, termination and antitermination
HUT08_RS22110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT08_RS22115	COG0081	regulation of translation
HUT08_RS22125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUT08_RS22130	COG0222	ribosome binding
HUT08_RS22135	COG0085	RNA polymerase activity
HUT08_RS22140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT08_RS22150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT08_RS22155	COG0049	tRNA binding
HUT08_RS22160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT08_RS22165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT08_RS22190	COG0051	transcription antitermination factor activity, RNA binding
HUT08_RS22195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT08_RS22200	COG0088	Forms part of the polypeptide exit tunnel
HUT08_RS22205	COG0089	rRNA binding
HUT08_RS22210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT08_RS22215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT08_RS22220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT08_RS22225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT08_RS22230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT08_RS22235	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT08_RS22240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT08_RS22245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT08_RS22250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT08_RS22255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT08_RS22260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT08_RS22265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT08_RS22270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT08_RS22275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT08_RS22280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT08_RS22290	COG0200	Binds to the 23S rRNA
HUT08_RS22300	COG0563	adenylate kinase activity
HUT08_RS22310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT08_RS22315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT08_RS22320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT08_RS22325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT08_RS22330	COG0202	RNA polymerase activity
HUT08_RS22335	COG0203	ribosomal protein L17
HUT08_RS22340	COG0101	tRNA pseudouridine synthase activity
HUT08_RS22345	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS22355	COG0488	(ABC) transporter
HUT08_RS22360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT08_RS22365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT08_RS22370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT08_RS22395	COG0702	epimerase
HUT08_RS22500	COG1072	(Pantothenic acid kinase))
HUT08_RS22505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT08_RS22510	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT08_RS22520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT08_RS22530	COG0802	atpase or kinase
HUT08_RS22550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT08_RS22565	COG2226	methyltransferase
HUT08_RS22600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT08_RS22610	COG4221	oxidoreductase activity
HUT08_RS22620	COG0583	DNA-binding transcription factor activity
HUT08_RS22630	COG2197	response regulator
HUT08_RS22635	COG1595	DNA-templated transcription, initiation
HUT08_RS22650	COG0516	GMP reductase activity
HUT08_RS22665	COG1077	Cell shape determining protein MreB Mrl
HUT08_RS22695	COG0515	serine threonine protein kinase
HUT08_RS22715	COG2072	flavoprotein involved in K transport
HUT08_RS22725	COG0259	pyridoxamine-phosphate oxidase activity
HUT08_RS22740	COG1309	transcriptional regulator
HUT08_RS22750	COG2197	response regulator
HUT08_RS22780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS22780	COG0515	serine threonine protein kinase
HUT08_RS22830	COG0531	amino acid
HUT08_RS22845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT08_RS22850	COG3708	Transcriptional regulator
HUT08_RS22850	COG2207	Transcriptional regulator
HUT08_RS22865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS22885	COG1686	Belongs to the peptidase S11 family
HUT08_RS22905	COG0789	Transcriptional regulator
HUT08_RS22915	COG0514	ATP-dependent DNA helicase (RecQ)
HUT08_RS22925	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT08_RS22940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT08_RS22945	COG0640	Transcriptional regulator
HUT08_RS22950	COG0798	PFAM Bile acid sodium symporter
HUT08_RS22955	COG2226	methyltransferase
HUT08_RS23015	COG1309	transcriptional regulator
HUT08_RS23035	COG1846	Transcriptional regulator
HUT08_RS23050	COG3191	aminopeptidase activity
HUT08_RS23055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT08_RS23065	COG1970	mechanosensitive ion channel activity
HUT08_RS23075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT08_RS23090	COG3263	regulation of cellular component size
HUT08_RS23100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT08_RS23105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT08_RS23115	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT08_RS23120	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT08_RS23125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT08_RS23145	COG4941	Belongs to the sigma-70 factor family
HUT08_RS23150	COG3795	YCII-related domain
HUT08_RS23155	COG0154	amidase activity
HUT08_RS23165	COG0583	DNA-binding transcription factor activity
HUT08_RS23185	COG3173	Aminoglycoside phosphotransferase
HUT08_RS23200	COG0708	Exodeoxyribonuclease III
HUT08_RS23210	COG2072	flavoprotein involved in K transport
HUT08_RS23215	COG2267	carboxylic ester hydrolase activity
HUT08_RS23220	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS23230	COG0793	Belongs to the peptidase S41A family
HUT08_RS23230	COG4946	Tricorn protease homolog
HUT08_RS23240	COG2409	Drug exporters of the RND superfamily
HUT08_RS23300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS23320	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HUT08_RS23335	COG1335	isochorismatase
HUT08_RS23355	COG0084	hydrolase, TatD family'
HUT08_RS23360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT08_RS23365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT08_RS23370	COG0488	(ABC) transporter
HUT08_RS23405	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT08_RS23415	COG2197	response regulator
HUT08_RS23420	COG1846	Transcriptional regulator
HUT08_RS23425	COG4106	trans-aconitate 2-methyltransferase activity
HUT08_RS23440	COG1309	transcriptional regulator
HUT08_RS23450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT08_RS23475	COG0193	aminoacyl-tRNA hydrolase activity
HUT08_RS23480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT08_RS23485	COG0768	penicillin binding
HUT08_RS23490	COG0583	DNA-binding transcription factor activity
HUT08_RS23500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT08_RS23505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT08_RS23555	COG0477	Major facilitator Superfamily
HUT08_RS23560	COG1136	(ABC) transporter
HUT08_RS23565	COG0577	efflux transmembrane transporter activity
HUT08_RS23630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT08_RS23660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT08_RS23675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT08_RS23685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT08_RS23695	COG2255	four-way junction helicase activity
HUT08_RS23700	COG1331	Highly conserved protein containing a thioredoxin domain
HUT08_RS23705	COG1063	alcohol dehydrogenase
HUT08_RS23715	COG2814	Major facilitator Superfamily
HUT08_RS23725	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT08_RS23755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT08_RS23770	COG1414	Transcriptional regulator
HUT08_RS23775	COG0251	oxidation-reduction process
HUT08_RS23780	COG2610	gluconate transmembrane transporter activity
HUT08_RS23815	COG1309	transcriptional regulator
HUT08_RS23870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT08_RS23895	COG1473	amidohydrolase
HUT08_RS23935	COG2894	cell division
HUT08_RS23985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUT08_RS23990	COG0667	Aldo Keto reductase
HUT08_RS23995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT08_RS24000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT08_RS24015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS24020	COG0450	alkyl hydroperoxide reductase
HUT08_RS24040	COG1136	(ABC) transporter
HUT08_RS24060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT08_RS24070	COG2264	protein methyltransferase activity
HUT08_RS24080	COG0114	fumarate hydratase activity
HUT08_RS24090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT08_RS24090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT08_RS24115	COG0778	Nitroreductase
HUT08_RS24120	COG1722	exodeoxyribonuclease VII activity
HUT08_RS24125	COG1570	exodeoxyribonuclease VII activity
HUT08_RS24140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT08_RS24155	COG0012	GTP binding
HUT08_RS24160	COG2161	toxin-antitoxin pair type II binding
HUT08_RS24165	COG4115	mRNA cleavage
HUT08_RS24185	COG2814	Major facilitator Superfamily
HUT08_RS24230	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS24245	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT08_RS24260	COG1395	domain, Protein
HUT08_RS24275	COG4941	Belongs to the sigma-70 factor family
HUT08_RS24300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT08_RS24315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT08_RS24320	COG0142	geranyltranstransferase activity
HUT08_RS24390	COG1217	gtp-binding protein TYPA
HUT08_RS24400	COG0601	transmembrane transport
HUT08_RS24405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS24410	COG0444	Belongs to the ABC transporter superfamily
HUT08_RS24415	COG4608	Belongs to the ABC transporter superfamily
HUT08_RS24460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT08_RS24465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT08_RS24510	COG0596	Alpha beta hydrolase
HUT08_RS24525	COG0601	transmembrane transport
HUT08_RS24530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS24535	COG0444	Belongs to the ABC transporter superfamily
HUT08_RS24540	COG4608	Belongs to the ABC transporter superfamily
HUT08_RS24605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT08_RS24620	COG4608	Belongs to the ABC transporter superfamily
HUT08_RS24635	COG0747	negative chemotaxis
HUT08_RS24640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS24665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT08_RS24710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT08_RS24715	COG1611	Belongs to the LOG family
HUT08_RS24720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT08_RS24730	COG0519	Catalyzes the synthesis of GMP from XMP
HUT08_RS24735	COG1024	Enoyl-CoA hydratase
HUT08_RS24750	COG1595	DNA-templated transcription, initiation
HUT08_RS24760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT08_RS24765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT08_RS24810	COG0598	Magnesium transport protein CorA
HUT08_RS24820	COG2814	Major facilitator Superfamily
HUT08_RS24830	COG0613	PHP domain protein
HUT08_RS24835	COG2095	MarC family integral membrane protein
HUT08_RS24845	COG1432	Conserved Protein
HUT08_RS24905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT08_RS24915	COG4172	Belongs to the ABC transporter superfamily
HUT08_RS24985	COG0210	DNA helicase
HUT08_RS24990	COG0210	DNA helicase
HUT08_RS24995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT08_RS25030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT08_RS25085	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT08_RS25095	COG1615	UPF0182 protein
HUT08_RS25115	COG4638	Rieske (2fe-2S)
HUT08_RS25125	COG0753	catalase activity
HUT08_RS25135	COG0483	inositol monophosphate 1-phosphatase activity
HUT08_RS25155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT08_RS25165	COG2135	peptidase activity
HUT08_RS25175	COG1595	DNA-templated transcription, initiation
HUT08_RS25200	COG0242	peptide deformylase activity
HUT08_RS25210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT08_RS25225	COG1966	Carbon starvation protein
HUT08_RS25235	COG2188	Transcriptional regulator
HUT08_RS25240	COG2182	Extracellular solute-binding protein
HUT08_RS25245	COG1175	transmembrane transport
HUT08_RS25250	COG0395	ABC-type sugar transport system, permease component
HUT08_RS25255	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT08_RS25260	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS25265	COG1309	transcriptional regulator
HUT08_RS25280	COG1597	lipid kinase activity
HUT08_RS25325	COG2066	Belongs to the glutaminase family
HUT08_RS25330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT08_RS25340	COG0598	Magnesium transport protein CorA
HUT08_RS25370	COG4106	trans-aconitate 2-methyltransferase activity
HUT08_RS25375	COG1126	abc transporter atp-binding protein
HUT08_RS25380	COG0765	amino acid transport
HUT08_RS25390	COG0281	malic enzyme
HUT08_RS25395	COG0604	alcohol dehydrogenase
HUT08_RS25435	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS25435	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS25435	COG0300	oxidoreductase activity
HUT08_RS25435	COG3321	synthase
HUT08_RS25435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS25450	COG0778	Nitroreductase
HUT08_RS25485	COG2255	four-way junction helicase activity
HUT08_RS25525	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT08_RS25525	COG0567	Dehydrogenase, E1 component
HUT08_RS25530	COG2205	protein histidine kinase activity
HUT08_RS25540	COG0745	RESPONSE REGULATOR receiver
HUT08_RS25565	COG1733	regulation of RNA biosynthetic process
HUT08_RS25575	COG2197	response regulator
HUT08_RS25580	COG4585	Histidine kinase
HUT08_RS25585	COG2409	Drug exporters of the RND superfamily
HUT08_RS25590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT08_RS25595	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT08_RS25610	COG2409	Drug exporters of the RND superfamily
HUT08_RS25685	COG2318	DinB family
HUT08_RS25755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT08_RS25760	COG0702	epimerase
HUT08_RS25765	COG2409	Drug exporters of the RND superfamily
HUT08_RS25775	COG2226	methyltransferase
HUT08_RS25790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT08_RS25810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT08_RS25835	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT08_RS25835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT08_RS25840	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT08_RS25855	COG0583	DNA-binding transcription factor activity
HUT08_RS25870	COG3540	Alkaline phosphatase
HUT08_RS25885	COG2197	response regulator
HUT08_RS25905	COG0604	alcohol dehydrogenase
HUT08_RS25905	COG3321	synthase
HUT08_RS25940	COG2409	Drug exporters of the RND superfamily
HUT08_RS25945	COG1309	transcriptional regulator
HUT08_RS25985	COG0667	Aldo Keto reductase
HUT08_RS26030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT08_RS26035	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS26040	COG0477	Major facilitator Superfamily
HUT08_RS26045	COG1846	Transcriptional regulator
HUT08_RS26060	COG2188	Transcriptional regulator
HUT08_RS26095	COG0018	arginyl-trna synthetase
HUT08_RS26100	COG0019	diaminopimelate decarboxylase activity
HUT08_RS26105	COG0460	homoserine dehydrogenase
HUT08_RS26110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT08_RS26115	COG0083	homoserine kinase activity
HUT08_RS26125	COG1316	TRANSCRIPTIONal
HUT08_RS26130	COG0254	rRNA binding
HUT08_RS26135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT08_RS26140	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT08_RS26150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT08_RS26155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT08_RS26175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT08_RS26180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT08_RS26185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT08_RS26190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT08_RS26195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT08_RS26200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT08_RS26205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT08_RS26225	COG2197	response regulator
HUT08_RS26230	COG4585	Histidine kinase
HUT08_RS26260	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS26275	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT08_RS26330	COG0183	Belongs to the thiolase family
HUT08_RS26345	COG0745	RESPONSE REGULATOR receiver
HUT08_RS26405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS26405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS26450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT08_RS26455	COG0857	belongs to the CobB CobQ family
HUT08_RS26455	COG0280	phosphate acetyltransferase
HUT08_RS26460	COG0205	6-phosphofructokinase activity
HUT08_RS26490	COG0702	epimerase
HUT08_RS26500	COG3833	ABC-type maltose transport systems, permease component
HUT08_RS26505	COG1175	transmembrane transport
HUT08_RS26520	COG4565	transcriptional regulatory protein
HUT08_RS26525	COG3290	protein histidine kinase activity
HUT08_RS26530	COG1301	dicarboxylic acid transport
HUT08_RS26535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT08_RS26555	COG0366	Alpha amylase catalytic
HUT08_RS26560	COG1733	regulation of RNA biosynthetic process
HUT08_RS26565	COG0596	Alpha beta hydrolase
HUT08_RS26585	COG0058	SHG alpha-glucan phosphorylase activity
HUT08_RS26620	COG1132	(ABC) transporter
HUT08_RS26625	COG1132	(ABC) transporter
HUT08_RS26675	COG0583	DNA-binding transcription factor activity
HUT08_RS26695	COG3118	belongs to the thioredoxin family
HUT08_RS26705	COG0492	ferredoxin-NADP+ reductase activity
HUT08_RS26725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT08_RS26725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT08_RS26745	COG2814	Major facilitator Superfamily
HUT08_RS26750	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS26760	COG4941	Belongs to the sigma-70 factor family
HUT08_RS26775	COG1760	l-serine dehydratase
HUT08_RS26780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT08_RS26785	COG0509	glycine decarboxylation via glycine cleavage system
HUT08_RS26790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT08_RS26825	COG0444	Belongs to the ABC transporter superfamily
HUT08_RS26830	COG4608	Belongs to the ABC transporter superfamily
HUT08_RS26835	COG2860	membrane
HUT08_RS26860	COG3629	intracellular signal transduction
HUT08_RS26860	COG3629	intracellular signal transduction
HUT08_RS26860	COG3903	Transcriptional regulator
HUT08_RS26860	COG3903	Transcriptional regulator
HUT08_RS26880	COG0482	sulfurtransferase activity
HUT08_RS26885	COG1611	Belongs to the LOG family
HUT08_RS26900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT08_RS26915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT08_RS26920	COG0154	amidase activity
HUT08_RS26930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT08_RS26945	COG2814	Major facilitator Superfamily
HUT08_RS26955	COG3511	phospholipase C
HUT08_RS26960	COG2409	Drug exporters of the RND superfamily
HUT08_RS26965	COG1078	dGTPase activity
HUT08_RS26975	COG2197	response regulator
HUT08_RS26980	COG2133	pyrroloquinoline quinone binding
HUT08_RS26995	COG0667	Aldo Keto reductase
HUT08_RS27015	COG0440	acetolactate synthase activity
HUT08_RS27020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT08_RS27025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT08_RS27055	COG0506	proline dehydrogenase activity
HUT08_RS27060	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS27070	COG0473	3-isopropylmalate dehydrogenase activity
HUT08_RS27075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS27080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT08_RS27085	COG2353	YceI-like domain
HUT08_RS27095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT08_RS27115	COG2018	Roadblock/LC7 domain
HUT08_RS27135	COG2018	Roadblock/LC7 domain
HUT08_RS27140	COG5002	protein histidine kinase activity
HUT08_RS27150	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT08_RS27155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT08_RS27185	COG1414	Transcriptional regulator
HUT08_RS27190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT08_RS27195	COG0066	3-isopropylmalate dehydratase activity
HUT08_RS27205	COG0776	regulation of translation
HUT08_RS27215	COG1920	GTP binding
HUT08_RS27225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT08_RS27230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT08_RS27250	COG0351	phosphomethylpyrimidine kinase
HUT08_RS27255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT08_RS27260	COG1461	Dihydroxyacetone kinase
HUT08_RS27270	COG0742	ribosomal rna small subunit methyltransferase
HUT08_RS27275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT08_RS27290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT08_RS27295	COG0571	ribonuclease III activity
HUT08_RS27300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT08_RS27305	COG1254	Belongs to the acylphosphatase family
HUT08_RS27320	COG0477	Major facilitator Superfamily
HUT08_RS27360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT08_RS27370	COG0442	prolyl-tRNA aminoacylation
HUT08_RS27380	COG0228	four-way junction DNA binding
HUT08_RS27385	COG1837	Belongs to the UPF0109 family
HUT08_RS27390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT08_RS27395	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT08_RS27400	COG0335	large ribosomal subunit rRNA binding
HUT08_RS27410	COG0681	Belongs to the peptidase S26 family
HUT08_RS27415	COG0681	Belongs to the peptidase S26 family
HUT08_RS27435	COG0792	nuclease activity
HUT08_RS27560	COG4974	Belongs to the 'phage' integrase family
HUT08_RS27570	COG1191	sigma factor activity
HUT08_RS27585	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT08_RS27590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT08_RS27595	COG0528	UMP kinase activity
HUT08_RS27600	COG0233	cytoplasmic translational termination
HUT08_RS27610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT08_RS27625	COG3842	ATPase activity
HUT08_RS27635	COG1136	(ABC) transporter
HUT08_RS27640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT08_RS27650	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS27660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT08_RS27695	COG2508	Transcriptional regulator
HUT08_RS27700	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS27710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUT08_RS27715	COG0750	zinc metalloprotease
HUT08_RS27720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT08_RS27735	COG0442	prolyl-tRNA aminoacylation
HUT08_RS27755	COG0779	Required for maturation of 30S ribosomal subunits
HUT08_RS27770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT08_RS27780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT08_RS27785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT08_RS27795	COG0455	bacterial-type flagellum organization
HUT08_RS27815	COG3266	domain, Protein
HUT08_RS27820	COG1404	Belongs to the peptidase S8 family
HUT08_RS27835	COG1404	Belongs to the peptidase S8 family
HUT08_RS27850	COG1674	ftsk spoiiie
HUT08_RS27860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT08_RS27865	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT08_RS27870	COG0612	Peptidase, M16
HUT08_RS27875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT08_RS27895	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT08_RS27900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT08_RS27905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT08_RS27940	COG2205	protein histidine kinase activity
HUT08_RS27940	COG3437	response regulator, receiver
HUT08_RS27940	COG3850	Histidine kinase
HUT08_RS27940	COG4999	Histidine kinase
HUT08_RS27950	COG1674	ftsk spoiiie
HUT08_RS27960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT08_RS27970	COG1058	Belongs to the CinA family
HUT08_RS27970	COG1546	Belongs to the CinA family
HUT08_RS27975	COG1396	sequence-specific DNA binding
HUT08_RS27980	COG0783	Belongs to the Dps family
HUT08_RS27985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT08_RS27990	COG1201	RNA secondary structure unwinding
HUT08_RS28020	COG0628	permease
HUT08_RS28030	COG2137	regulation of response to DNA damage stimulus
HUT08_RS28045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT08_RS28050	COG0765	amino acid transport
HUT08_RS28055	COG0765	amino acid transport
HUT08_RS28060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT08_RS28065	COG1126	abc transporter atp-binding protein
HUT08_RS28075	COG2205	protein histidine kinase activity
HUT08_RS28090	COG2358	TRAP transporter, solute receptor (TAXI family
HUT08_RS28095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT08_RS28115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT08_RS28125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT08_RS28140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT08_RS28170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT08_RS28175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT08_RS28180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT08_RS28205	COG0488	(ABC) transporter
HUT08_RS28210	COG0588	phosphoglycerate mutase activity
HUT08_RS28220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT08_RS28235	COG0514	ATP-dependent DNA helicase (RecQ)
HUT08_RS28250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT08_RS28255	COG2186	Transcriptional regulator
HUT08_RS28260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT08_RS28275	COG0187	DNA topoisomerase II activity
HUT08_RS28280	COG4565	transcriptional regulatory protein
HUT08_RS28285	COG3290	protein histidine kinase activity
HUT08_RS28295	COG0372	Belongs to the citrate synthase family
HUT08_RS28300	COG0372	Belongs to the citrate synthase family
HUT08_RS28310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT08_RS28315	COG0612	Peptidase, M16
HUT08_RS28330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT08_RS28355	COG1435	thymidine kinase activity
HUT08_RS28390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUT08_RS28395	COG0483	inositol monophosphate 1-phosphatase activity
HUT08_RS28405	COG0745	RESPONSE REGULATOR receiver
HUT08_RS28410	COG2205	protein histidine kinase activity
HUT08_RS28435	COG0756	dUTP diphosphatase activity
HUT08_RS28450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUT08_RS28455	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUT08_RS28460	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUT08_RS28465	COG1136	(ABC) transporter
HUT08_RS28465	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUT08_RS28515	COG0569	domain protein
HUT08_RS28550	COG0531	amino acid
HUT08_RS28555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT08_RS28585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT08_RS28600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT08_RS28620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS28625	COG0583	DNA-binding transcription factor activity
HUT08_RS28650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT08_RS28660	COG2264	protein methyltransferase activity
HUT08_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS28675	COG1799	cell septum assembly
HUT08_RS28705	COG2040	homocysteine
HUT08_RS28715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT08_RS28725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT08_RS28730	COG0531	amino acid
HUT08_RS28735	COG1024	Enoyl-CoA hydratase
HUT08_RS28750	COG0477	Major facilitator Superfamily
HUT08_RS28770	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS28780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS28785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS28790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT08_RS28795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT08_RS28805	COG2226	methyltransferase
HUT08_RS28825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT08_RS28830	COG1653	transport
HUT08_RS28835	COG1175	transmembrane transport
HUT08_RS28840	COG0395	ABC-type sugar transport system, permease component
HUT08_RS28845	COG1940	carbohydrate kinase activity
HUT08_RS28850	COG4213	ABC transporter substrate-binding protein
HUT08_RS28860	COG4214	carbohydrate transport
HUT08_RS28865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT08_RS28870	COG0531	amino acid
HUT08_RS28895	COG1024	Enoyl-CoA hydratase
HUT08_RS28895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS28900	COG0183	Belongs to the thiolase family
HUT08_RS28920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT08_RS28925	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT08_RS28945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT08_RS28950	COG3253	May function as heme-dependent peroxidase
HUT08_RS28965	COG3220	belongs to the UPF0276 family
HUT08_RS28970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT08_RS29015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT08_RS29020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT08_RS29030	COG2197	response regulator
HUT08_RS29045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT08_RS29050	COG0583	DNA-binding transcription factor activity
HUT08_RS29080	COG1175	transmembrane transport
HUT08_RS29110	COG1247	-acetyltransferase
HUT08_RS29135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT08_RS29140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUT08_RS29160	COG0529	Catalyzes the synthesis of activated sulfate
HUT08_RS29165	COG0175	sulfate reduction
HUT08_RS29175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT08_RS29180	COG0456	acetyltransferase
HUT08_RS29205	COG1162	GTPase activity
HUT08_RS29220	COG1278	Cold shock
HUT08_RS29230	COG2267	carboxylic ester hydrolase activity
HUT08_RS29250	COG0028	Belongs to the TPP enzyme family
HUT08_RS29290	COG3835	regulator
HUT08_RS29305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT08_RS29310	COG2252	PERMEase
HUT08_RS29325	COG3220	belongs to the UPF0276 family
HUT08_RS29340	COG3540	Alkaline phosphatase
HUT08_RS29350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS29375	COG0859	PFAM glycosyl transferase family 9
HUT08_RS29380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT08_RS29380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT08_RS29385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT08_RS29390	COG0297	glycogen (starch) synthase activity
HUT08_RS29415	COG2192	nodulation
HUT08_RS29420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT08_RS29425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT08_RS29450	COG1115	amino acid carrier protein
HUT08_RS29455	COG0598	Magnesium transport protein CorA
HUT08_RS29470	COG2197	response regulator
HUT08_RS29475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT08_RS29480	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS29485	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS29510	COG2351	hydroxyisourate hydrolase activity
HUT08_RS29525	COG2233	PERMEase
HUT08_RS29545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUT08_RS29560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS29560	COG0515	serine threonine protein kinase
HUT08_RS29565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS29565	COG0515	serine threonine protein kinase
HUT08_RS29575	COG1414	Transcriptional regulator
HUT08_RS29580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT08_RS29605	COG0800	Aldolase
HUT08_RS29610	COG2188	Transcriptional regulator
HUT08_RS29630	COG1940	carbohydrate kinase activity
HUT08_RS29645	COG0789	Transcriptional regulator
HUT08_RS29680	COG3321	synthase
HUT08_RS29680	COG0604	alcohol dehydrogenase
HUT08_RS29705	COG0604	alcohol dehydrogenase
HUT08_RS29705	COG3321	synthase
HUT08_RS29710	COG3321	synthase
HUT08_RS29710	COG0604	alcohol dehydrogenase
HUT08_RS29715	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS29740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT08_RS29745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT08_RS29765	COG1126	abc transporter atp-binding protein
HUT08_RS29770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT08_RS29775	COG0765	amino acid transport
HUT08_RS29780	COG0765	amino acid transport
HUT08_RS29790	COG0405	Gamma-glutamyltransferase
HUT08_RS29810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT08_RS29830	COG0483	inositol monophosphate 1-phosphatase activity
HUT08_RS29860	COG1652	LysM domain
HUT08_RS29885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT08_RS29890	COG1929	Belongs to the glycerate kinase type-1 family
HUT08_RS29900	COG0688	phosphatidylethanolamine metabolic process
HUT08_RS29905	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS29915	COG2301	Belongs to the HpcH HpaI aldolase family
HUT08_RS29920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS29920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT08_RS29925	COG0604	alcohol dehydrogenase
HUT08_RS29935	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT08_RS29955	COG0587	DNA-directed DNA polymerase activity
HUT08_RS29960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT08_RS29965	COG1959	2 iron, 2 sulfur cluster binding
HUT08_RS30000	COG0019	diaminopimelate decarboxylase activity
HUT08_RS30010	COG0745	RESPONSE REGULATOR receiver
HUT08_RS30020	COG0778	Nitroreductase
HUT08_RS30050	COG0456	acetyltransferase
HUT08_RS30055	COG1725	Transcriptional regulator
HUT08_RS30090	COG2188	Transcriptional regulator
HUT08_RS30095	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUT08_RS30100	COG2851	Citrate transporter
HUT08_RS30140	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS30175	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS30185	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS30205	COG2149	membrane
HUT08_RS30210	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT08_RS30260	COG0297	glycogen (starch) synthase activity
HUT08_RS30265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT08_RS30330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT08_RS30355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT08_RS30360	COG0667	Aldo Keto reductase
HUT08_RS30365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS30375	COG0598	Magnesium transport protein CorA
HUT08_RS30395	COG0215	cysteine-tRNA ligase activity
HUT08_RS30410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT08_RS30415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT08_RS30420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT08_RS30425	COG1414	Transcriptional regulator
HUT08_RS30430	COG0646	methionine synthase
HUT08_RS30430	COG1410	methionine synthase
HUT08_RS30435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT08_RS30440	COG0747	negative chemotaxis
HUT08_RS30450	COG2197	response regulator
HUT08_RS30460	COG0517	IMP dehydrogenase activity
HUT08_RS30460	COG1994	Peptidase M50
HUT08_RS30480	COG1222	aaa ATPase
HUT08_RS30485	COG4122	O-methyltransferase activity
HUT08_RS30495	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT08_RS30510	COG1522	sequence-specific DNA binding
HUT08_RS30515	COG1609	Transcriptional regulator
HUT08_RS30525	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT08_RS30530	COG0545	Peptidyl-prolyl cis-trans isomerase
HUT08_RS30560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT08_RS30565	COG0805	protein transport
HUT08_RS30585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT08_RS30590	COG3448	diguanylate cyclase activity
HUT08_RS30590	COG4175	Glycine betaine
HUT08_RS30625	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT08_RS30630	COG0531	amino acid
HUT08_RS30645	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS30680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT08_RS30695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT08_RS30700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT08_RS30705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT08_RS30710	COG5002	protein histidine kinase activity
HUT08_RS30715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT08_RS30720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT08_RS30720	COG0072	phenylalanine-tRNA ligase activity
HUT08_RS30745	COG3903	Transcriptional regulator
HUT08_RS30745	COG3629	intracellular signal transduction
HUT08_RS30775	COG1649	PFAM Uncharacterised BCR, COG1649
HUT08_RS30785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS30805	COG1280	lysine exporter protein (LysE YggA)
HUT08_RS30830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT08_RS30835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT08_RS30840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT08_RS30845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT08_RS30850	COG1438	arginine binding
HUT08_RS30870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS30885	COG3629	intracellular signal transduction
HUT08_RS30885	COG3903	Transcriptional regulator
HUT08_RS30925	COG0137	argininosuccinate synthase activity
HUT08_RS30930	COG0165	Argininosuccinate lyase
HUT08_RS30940	COG0477	Major facilitator Superfamily
HUT08_RS30960	COG0204	Acyl-transferase
HUT08_RS30960	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS30965	COG0584	glycerophosphoryl diester phosphodiesterase
HUT08_RS31005	COG2011	ABC-type metal ion transport system permease component
HUT08_RS31010	COG1464	Belongs to the NlpA lipoprotein family
HUT08_RS31025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT08_RS31030	COG1648	precorrin-2 dehydrogenase activity
HUT08_RS31030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT08_RS31035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT08_RS31040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT08_RS31040	COG0515	serine threonine protein kinase
HUT08_RS31085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT08_RS31095	COG0456	acetyltransferase
HUT08_RS31095	COG0454	-acetyltransferase
HUT08_RS31150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT08_RS31170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT08_RS31175	COG1560	Kdo2-lipid A biosynthetic process
HUT08_RS31180	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS31195	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT08_RS31200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT08_RS31205	COG0217	transcriptional regulatory protein
HUT08_RS31215	COG0632	four-way junction helicase activity
HUT08_RS31220	COG2255	four-way junction helicase activity
HUT08_RS31230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT08_RS31235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT08_RS31240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT08_RS31245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT08_RS31255	COG1846	Transcriptional regulator
HUT08_RS31275	COG1196	nuclear chromosome segregation
HUT08_RS31280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT08_RS31290	COG0124	histidyl-tRNA synthetase
HUT08_RS31310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT08_RS31330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT08_RS31335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT08_RS31345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT08_RS31350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT08_RS31355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT08_RS31360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT08_RS31365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT08_RS31375	COG0006	proline dipeptidase activity
HUT08_RS31380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT08_RS31385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT08_RS31395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT08_RS31400	COG0540	Belongs to the ATCase OTCase family
HUT08_RS31405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT08_RS31415	COG0505	Belongs to the CarA family
HUT08_RS31420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT08_RS31425	COG0167	dihydroorotate dehydrogenase activity
HUT08_RS31430	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT08_RS31455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT08_RS31470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT08_RS31485	COG2814	Major facilitator Superfamily
HUT08_RS31495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUT08_RS31500	COG2390	Transcriptional regulator
HUT08_RS31530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS31580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT08_RS31595	COG2233	PERMEase
HUT08_RS31600	COG2223	nitrite transmembrane transporter activity
HUT08_RS31605	COG1940	carbohydrate kinase activity
HUT08_RS31605	COG1846	Transcriptional regulator
HUT08_RS31610	COG4977	sequence-specific DNA binding
HUT08_RS31635	COG3201	nicotinamide mononucleotide transporter
HUT08_RS31640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT08_RS31640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT08_RS31645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT08_RS31650	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT08_RS31655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT08_RS31710	COG0531	amino acid
HUT08_RS31720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT08_RS31755	COG0326	Molecular chaperone. Has ATPase activity
HUT08_RS31765	COG0583	DNA-binding transcription factor activity
HUT08_RS31770	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS31815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUT08_RS31860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT08_RS31870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT08_RS31895	COG0657	acetylesterase activity
HUT08_RS31915	COG0475	glutathione-regulated potassium exporter activity
HUT08_RS31935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUT08_RS31940	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HUT08_RS31955	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS31970	COG1121	(ABC) transporter
HUT08_RS31975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT08_RS31995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT08_RS32000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT08_RS32005	COG0523	cobalamin synthesis protein
HUT08_RS32030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT08_RS32070	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS32120	COG0515	serine threonine protein kinase
HUT08_RS32135	COG1132	(ABC) transporter
HUT08_RS32140	COG1132	(ABC) transporter
HUT08_RS32145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT08_RS32150	COG1120	ATPase activity
HUT08_RS32155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS32160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS32175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT08_RS32175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT08_RS32195	COG0753	catalase activity
HUT08_RS32230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT08_RS32240	COG1132	(ABC) transporter
HUT08_RS32310	COG0789	Transcriptional regulator
HUT08_RS32385	COG0464	growth
HUT08_RS32400	COG2197	response regulator
HUT08_RS32435	COG1278	Cold shock
HUT08_RS32440	COG0513	Belongs to the DEAD box helicase family
HUT08_RS32475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT08_RS32480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT08_RS32500	COG0473	3-isopropylmalate dehydrogenase activity
HUT08_RS32510	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS32525	COG3961	Belongs to the TPP enzyme family
HUT08_RS32545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT08_RS32550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT08_RS32555	COG0066	3-isopropylmalate dehydratase activity
HUT08_RS32595	COG0671	phosphoesterase, PA-phosphatase related
HUT08_RS32615	COG0584	glycerophosphoryl diester phosphodiesterase
HUT08_RS32655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT08_RS32665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT08_RS32685	COG0515	serine threonine protein kinase
HUT08_RS32685	COG2815	serine threonine protein kinase
HUT08_RS32690	COG0494	nUDIX hydrolase
HUT08_RS32710	COG0445	tRNA wobble uridine modification
HUT08_RS32725	COG4585	Histidine kinase
HUT08_RS32730	COG2197	response regulator
HUT08_RS32750	COG1940	carbohydrate kinase activity
HUT08_RS32795	COG1349	DNA-binding transcription factor activity
HUT08_RS32805	COG0464	growth
HUT08_RS32840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUT08_RS32890	COG1518	maintenance of DNA repeat elements
HUT08_RS32895	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUT08_RS32945	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS32975	COG2124	cytochrome p450
HUT08_RS33075	COG3293	Transposase
HUT08_RS33225	COG0563	adenylate kinase activity
HUT08_RS33315	COG0791	NLP P60 protein
HUT08_RS33315	COG1388	LysM domain
HUT08_RS33315	COG3103	Sh3 type 3 domain protein
HUT08_RS33345	COG2124	cytochrome p450
HUT08_RS33370	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS33375	COG0028	Belongs to the TPP enzyme family
HUT08_RS33385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT08_RS33425	COG0181	hydroxymethylbilane synthase activity
HUT08_RS33445	COG0501	Belongs to the peptidase M48B family
HUT08_RS33470	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT08_RS33480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS33485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT08_RS33525	COG1132	(ABC) transporter
HUT08_RS33530	COG1132	(ABC) transporter
HUT08_RS33540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT08_RS33540	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HUT08_RS33540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT08_RS33545	COG1461	Dihydroxyacetone kinase
HUT08_RS33550	COG2376	Dihydroxyacetone kinase
HUT08_RS33565	COG4977	sequence-specific DNA binding
HUT08_RS33590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT08_RS33595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT08_RS33610	COG0529	Catalyzes the synthesis of activated sulfate
HUT08_RS33620	COG1335	isochorismatase
HUT08_RS33630	COG0515	serine threonine protein kinase
HUT08_RS33630	COG2815	serine threonine protein kinase
HUT08_RS33635	COG3467	pyridoxamine 5'-phosphate
HUT08_RS33655	COG0515	serine threonine protein kinase
HUT08_RS33690	COG0510	thiamine kinase activity
HUT08_RS33715	COG0438	transferase activity, transferring glycosyl groups
HUT08_RS33735	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HUT08_RS33740	COG1984	allophanate hydrolase subunit 2
HUT08_RS33745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUT08_RS33750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUT08_RS33770	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUT08_RS33800	COG2018	Roadblock/LC7 domain
HUT08_RS33815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT08_RS33825	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT08_RS33835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT08_RS33865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT08_RS33905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT08_RS33915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT08_RS33915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT08_RS33940	COG0384	phenazine biosynthesis protein PhzF
HUT08_RS33955	COG1695	Transcriptional regulator
HUT08_RS33990	COG0697	spore germination
HUT08_RS34030	COG0726	polysaccharide deacetylase
HUT08_RS34040	COG3634	alkyl hydroperoxide reductase activity
HUT08_RS34075	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS34085	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT08_RS34120	COG0477	Major facilitator Superfamily
HUT08_RS34130	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS34140	COG4948	Mandelate Racemase Muconate Lactonizing
HUT08_RS34160	COG2318	DinB family
HUT08_RS34220	COG2124	cytochrome p450
HUT08_RS34225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT08_RS34250	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS34265	COG3321	synthase
HUT08_RS34265	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS34265	COG0604	alcohol dehydrogenase
HUT08_RS34300	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HUT08_RS34320	COG0142	geranyltranstransferase activity
HUT08_RS34350	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS34355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT08_RS34365	COG2318	DinB family
HUT08_RS34375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUT08_RS34390	COG1968	undecaprenyl-diphosphatase activity
HUT08_RS34400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT08_RS34425	COG2814	Major facilitator Superfamily
HUT08_RS34450	COG0110	maltose O-acetyltransferase activity
HUT08_RS34465	COG1832	CoA-binding protein
HUT08_RS34470	COG1739	Uncharacterized protein family UPF0029
HUT08_RS34475	COG0420	3'-5' exonuclease activity
HUT08_RS34480	COG0419	ATPase involved in DNA repair
HUT08_RS34500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS34515	COG2267	carboxylic ester hydrolase activity
HUT08_RS34525	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS34555	COG0142	geranyltranstransferase activity
HUT08_RS34560	COG2188	Transcriptional regulator
HUT08_RS34565	COG1940	carbohydrate kinase activity
HUT08_RS34570	COG2197	response regulator
HUT08_RS34575	COG4585	Histidine kinase
HUT08_RS34590	COG3663	DNA glycosylase
HUT08_RS34595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT08_RS34625	COG2226	methyltransferase
HUT08_RS34660	COG1309	transcriptional regulator
HUT08_RS34665	COG4221	oxidoreductase activity
HUT08_RS34670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT08_RS34675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT08_RS34680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT08_RS34685	COG0156	8-amino-7-oxononanoate synthase activity
HUT08_RS34695	COG3103	Sh3 type 3 domain protein
HUT08_RS34695	COG1388	LysM domain
HUT08_RS34695	COG0791	NLP P60 protein
HUT08_RS34705	COG0740	serine-type endopeptidase activity
HUT08_RS34755	COG0205	6-phosphofructokinase activity
HUT08_RS34760	COG1492	cobalamin metabolic process
HUT08_RS34770	COG0242	peptide deformylase activity
HUT08_RS34780	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS34790	COG1793	dna ligase
HUT08_RS34790	COG3285	dna ligase
HUT08_RS34795	COG0490	domain, Protein
HUT08_RS34820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUT08_RS34850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT08_RS34855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT08_RS34860	COG2080	2 iron, 2 sulfur cluster binding
HUT08_RS34880	COG0156	8-amino-7-oxononanoate synthase activity
HUT08_RS34885	COG1063	alcohol dehydrogenase
HUT08_RS34890	COG0583	DNA-binding transcription factor activity
HUT08_RS34945	COG0662	Cupin 2, conserved barrel domain protein
HUT08_RS34965	COG1846	Transcriptional regulator
HUT08_RS34990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT08_RS35000	COG0640	Transcriptional regulator
HUT08_RS35030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT08_RS35065	COG0604	alcohol dehydrogenase
HUT08_RS35065	COG3321	synthase
HUT08_RS35070	COG0318	PFAM AMP-dependent synthetase and ligase
HUT08_RS35110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT08_RS35120	COG2356	endonuclease I
HUT08_RS35150	COG0583	DNA-binding transcription factor activity
HUT08_RS35170	COG3012	SEC-C Motif Domain Protein
HUT08_RS35195	COG1414	Transcriptional regulator
HUT08_RS35200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT08_RS35210	COG3321	synthase
HUT08_RS35210	COG0604	alcohol dehydrogenase
HUT08_RS35235	COG3321	synthase
HUT08_RS35235	COG0604	alcohol dehydrogenase
HUT08_RS35240	COG3321	synthase
HUT08_RS35240	COG0604	alcohol dehydrogenase
HUT08_RS35245	COG0604	alcohol dehydrogenase
HUT08_RS35245	COG3321	synthase
HUT08_RS35270	COG2945	thiolester hydrolase activity
HUT08_RS35270	COG0596	Alpha beta hydrolase
HUT08_RS35385	COG3903	Transcriptional regulator
HUT08_RS35385	COG2197	response regulator
HUT08_RS35390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUT08_RS35395	COG2318	DinB family
HUT08_RS35420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT08_RS35425	COG0235	Class ii aldolase
HUT08_RS35430	COG1960	acyl-CoA dehydrogenase activity
HUT08_RS35440	COG0726	polysaccharide deacetylase
HUT08_RS35475	COG0596	Alpha beta hydrolase
HUT08_RS35485	COG3485	protocatechuate 3,4-dioxygenase
HUT08_RS35490	COG3485	protocatechuate 3,4-dioxygenase
HUT08_RS35510	COG1414	Transcriptional regulator
HUT08_RS35530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HUT08_RS35565	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT08_RS35570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT08_RS35575	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS35585	COG2814	Major facilitator Superfamily
HUT08_RS35590	COG0657	acetylesterase activity
HUT08_RS35595	COG0667	Aldo Keto reductase
HUT08_RS35620	COG2197	response regulator
HUT08_RS35625	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS35640	COG0747	negative chemotaxis
HUT08_RS35650	COG0444	Belongs to the ABC transporter superfamily
HUT08_RS35655	COG4172	Belongs to the ABC transporter superfamily
HUT08_RS35665	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS35680	COG0174	glutamine synthetase
HUT08_RS35695	COG4689	acetoacetate decarboxylase
HUT08_RS35710	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT08_RS35715	COG1309	transcriptional regulator
HUT08_RS35720	COG1012	belongs to the aldehyde dehydrogenase family
HUT08_RS35725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT08_RS35730	COG1846	Transcriptional regulator
HUT08_RS35740	COG0435	Glutathione S-transferase
HUT08_RS35770	COG2207	Transcriptional regulator
HUT08_RS35775	COG1028	Short-chain dehydrogenase reductase Sdr
HUT08_RS35780	COG1063	alcohol dehydrogenase
HUT08_RS35785	COG0477	Major facilitator Superfamily
HUT08_RS35800	COG1695	Transcriptional regulator
HUT08_RS35815	COG1309	transcriptional regulator
HUT08_RS35820	COG2084	Dehydrogenase
HUT08_RS35830	COG0477	Major facilitator Superfamily
HUT08_RS35865	COG1846	Transcriptional regulator
HUT08_RS35880	COG0076	glutamate decarboxylase activity
HUT08_RS35885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT08_RS35895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT08_RS36210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT08_RS36215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT08_RS36260	COG1442	glycosyl transferase family 8
HUT08_RS36275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUT08_RS36280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT08_RS36295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUT08_RS36320	COG2226	methyltransferase
HUT08_RS36345	COG1132	(ABC) transporter
HUT08_RS36350	COG1132	(ABC) transporter
HUT08_RS36390	COG2801	Transposase and inactivated derivatives