locus-tag class description G9272_RS00140 ENOG4105F7P transcriptional regulator AsnC family G9272_RS00155 ENOG4105NRA 50s ribosomal protein l31 type b G9272_RS00165 ENOG4105F27 Major Facilitator G9272_RS00170 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS00175 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G9272_RS00225 ENOG4108TVJ Nitroreductase G9272_RS00235 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G9272_RS00265 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G9272_RS00275 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G9272_RS00280 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS00285 ENOG4107STQ Multicopper oxidase G9272_RS00295 ENOG4108HMN Caspase domain G9272_RS00310 ENOG4106YKD Cytochrome p-450 G9272_RS00335 ENOG4105JAB phenazine biosynthesis protein, phzf family G9272_RS00345 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS00355 ENOG4106YKD Cytochrome p-450 G9272_RS00420 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G9272_RS00440 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G9272_RS00495 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G9272_RS00505 ENOG4107T4Z adenosine kinase G9272_RS00510 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G9272_RS00550 ENOG410680H amp-dependent synthetase and ligase G9272_RS00555 ENOG4105CS1 NAD(P)H quinone oxidoreductase G9272_RS00570 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G9272_RS00580 ENOG41065KQ synthase G9272_RS00625 ENOG41064MX Tetr family transcriptional regulator G9272_RS00640 ENOG4105DF6 Fe-S oxidoreductase G9272_RS00705 ENOG4105CHR reductase G9272_RS00750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G9272_RS00775 ENOG4106NMR serine protease G9272_RS00830 ENOG4107RSM transcriptional regulator G9272_RS00925 ENOG4105E2B Taurine dioxygenase G9272_RS00970 ENOG4105S7M extracellular small neutral protease G9272_RS01030 ENOG4105NAE bifunctional deaminase-reductase domain protein G9272_RS01045 ENOG4107QN1 sodium solute G9272_RS01065 ENOG4105CVK Glutamate decarboxylase G9272_RS01070 ENOG41065KQ synthase G9272_RS01090 ENOG4107SET aldo keto reductase G9272_RS01095 ENOG4108IND Tetr family transcriptional regulator G9272_RS01155 ENOG4108J2P Alpha beta hydrolase fold G9272_RS01160 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G9272_RS01245 ENOG4108FN7 Aldo keto reductase G9272_RS01265 ENOG4107Y80 Major Facilitator superfamily G9272_RS01345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9272_RS01350 ENOG4105C26 Dehydrogenase G9272_RS01370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS01425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G9272_RS01430 ENOG4105CK5 oxidoreductase G9272_RS01435 ENOG4105CK5 oxidoreductase G9272_RS01440 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G9272_RS01445 ENOG4105C2J ABC transporter G9272_RS01450 ENOG4105CNN ABC, transporter G9272_RS01460 ENOG4105D7K pfkb domain protein G9272_RS01470 ENOG4105DH8 myo-inositol catabolism G9272_RS01475 ENOG4105C26 Dehydrogenase G9272_RS01480 ENOG4105FDP GntR family transcriptional regulator G9272_RS01490 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G9272_RS01500 ENOG4105CK5 oxidoreductase G9272_RS01510 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G9272_RS01590 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G9272_RS01605 ENOG4105CPQ Dehydrogenase G9272_RS01610 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G9272_RS01635 ENOG4105NPE arsR family transcriptional regulator G9272_RS01645 ENOG4105DXX methyltransferase G9272_RS01670 ENOG4105CN5 Metallo-Beta-Lactamase G9272_RS01690 ENOG4105DA5 (ABC) transporter G9272_RS01725 ENOG4105EGE secreted protein G9272_RS01730 ENOG4107RSM transcriptional regulator G9272_RS01750 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS01795 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G9272_RS01800 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G9272_RS01805 ENOG4105C7W Xanthine dehydrogenase G9272_RS01845 ENOG4105DSG hydrolase family 43 G9272_RS01860 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS01905 ENOG4108RZE Tetr family transcriptional regulator G9272_RS01915 ENOG4105DSG hydrolase family 43 G9272_RS01950 ENOG4105D8K carboxyl transferase G9272_RS01960 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS02045 ENOG4107QN1 sodium solute G9272_RS02060 ENOG4106NZI LysR family Transcriptional regulator G9272_RS02075 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS02125 ENOG4105VEQ Cold shock protein G9272_RS02130 ENOG4105CBC glutamate synthase G9272_RS02135 ENOG4105C7K acetolactate synthase G9272_RS02180 ENOG4105CSH Transporter G9272_RS02185 ENOG4105Y3U Transglycosylase-associated protein G9272_RS02200 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS02210 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G9272_RS02220 ENOG4105CSH Transporter G9272_RS02250 ENOG4105N14 lysine exporter protein LysE YggA G9272_RS02265 ENOG41089UC methyltransferase, type 11 G9272_RS02320 ENOG4105F27 Major Facilitator G9272_RS02350 ENOG4108KK4 3-dehydroquinate synthase G9272_RS02375 ENOG4108IND Tetr family transcriptional regulator G9272_RS02380 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G9272_RS02415 ENOG4105CAQ asparagine synthetase G9272_RS02420 ENOG4105C0I Conserved Protein G9272_RS02445 ENOG4108IV0 ABC, transporter G9272_RS02455 ENOG4105C0Z ABC transporter G9272_RS02470 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G9272_RS02475 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS02485 ENOG4105CC9 acyl-Coa dehydrogenase G9272_RS02500 ENOG4105FDP GntR family transcriptional regulator G9272_RS02515 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS02530 ENOG4105CGU Enoyl-CoA hydratase G9272_RS02540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS02555 ENOG4105CC9 acyl-Coa dehydrogenase G9272_RS02560 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS02580 ENOG4108UKI Enoyl-CoA hydratase G9272_RS02590 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS02620 ENOG4105C26 Dehydrogenase G9272_RS02625 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS02630 ENOG4105CHR reductase G9272_RS02635 ENOG4105E39 Enoyl-CoA hydratase G9272_RS02640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS02645 ENOG4105CHR reductase G9272_RS02655 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS02660 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS02665 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS02680 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G9272_RS02700 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G9272_RS02705 ENOG4108M8W Monooxygenase G9272_RS02715 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS02725 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G9272_RS02735 ENOG4105YVS arsR family transcriptional regulator G9272_RS02790 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G9272_RS02795 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS02810 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component G9272_RS02815 ENOG4108IJ7 Glycine betaine G9272_RS02835 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G9272_RS02845 ENOG4105DVW rieske (2Fe-2S) G9272_RS02880 ENOG4108IG5 Transcriptional regulator G9272_RS02885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G9272_RS02935 ENOG4107RSM transcriptional regulator G9272_RS02955 ENOG4105ECQ AraC Family Transcriptional Regulator G9272_RS02965 ENOG4105BZP glycoside hydrolase 15-related G9272_RS02980 ENOG4106T9R serine protease G9272_RS02990 ENOG4105K4I Scp-like extracellular G9272_RS03005 ENOG41082JN Transcriptional regulator G9272_RS03025 ENOG4108SU4 UPF0309 protein G9272_RS03030 ENOG4105QEK Transcriptional regulator G9272_RS03055 ENOG4105DRS transport system, permease G9272_RS03075 ENOG4105D17 glycoside hydrolase, family 3 domain protein G9272_RS03090 ENOG4105C57 major facilitator superfamily G9272_RS03120 ENOG4105CMR udp-glucose 4-epimerase G9272_RS03125 ENOG4105BZU Histidine kinase G9272_RS03130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS03160 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G9272_RS03170 ENOG4106R7G Glycoside hydrolase family 5 G9272_RS03180 ENOG4107U9T Pfam:Ribonuclease_BN G9272_RS03280 ENOG4108KPJ rna polymerase sigma factor G9272_RS03300 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G9272_RS03345 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS03355 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G9272_RS03370 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS03380 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS03385 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9272_RS03445 ENOG4106A3M Cytochrome p-450 G9272_RS03460 ENOG4108IG5 Transcriptional regulator G9272_RS03465 ENOG4107RTD sua5 ycio yrdc ywlc family protein G9272_RS03485 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G9272_RS03520 ENOG4105CV8 reductase G9272_RS03550 ENOG4105TVJ transport system, permease G9272_RS03555 ENOG4105DQ5 transport system permease protein G9272_RS03560 ENOG4105E93 esterase G9272_RS03565 ENOG4108HUF Transporter G9272_RS03570 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G9272_RS03575 ENOG4105E4F Isochorismate synthase G9272_RS03580 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G9272_RS03585 ENOG4105WQI isochorismatase G9272_RS03590 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS03595 ENOG4105E93 esterase G9272_RS03610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS03630 ENOG4105BZU Histidine kinase G9272_RS03635 ENOG4108ZGX Histidine kinase G9272_RS03640 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS03645 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) G9272_RS03665 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G9272_RS03715 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G9272_RS03730 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G9272_RS03735 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G9272_RS03760 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS03765 ENOG4105BZU Histidine kinase G9272_RS03790 ENOG4107MMM Anti-sigma-factor antagonist G9272_RS03795 ENOG4105FUA antagonist G9272_RS03800 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G9272_RS03835 ENOG4108TM9 integral membrane protein G9272_RS03865 ENOG4105E8G Major facilitator Superfamily G9272_RS03875 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G9272_RS03895 ENOG4105BZU Histidine kinase G9272_RS03940 ENOG4105C5X domain protein G9272_RS03975 ENOG4107SM8 Adenylate Guanylate cyclase G9272_RS04000 ENOG4107QPV Serine Threonine protein kinase G9272_RS04010 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G9272_RS04025 ENOG4105CPC Aldo Keto reductase G9272_RS04040 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS04065 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G9272_RS04075 ENOG4105ESN nucleotide-binding protein G9272_RS04085 ENOG4108PA7 Methyltransferase G9272_RS04100 ENOG4105CIR epoxide hydrolase G9272_RS04105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G9272_RS04110 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G9272_RS04115 ENOG4105WBV Transcriptional regulator G9272_RS04120 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS04150 ENOG4105IDI abc transporter atp-binding protein G9272_RS04170 ENOG4105CPC Aldo Keto reductase G9272_RS04175 ENOG4108M0I Transcriptional regulator G9272_RS04185 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G9272_RS04190 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase G9272_RS04200 ENOG4107S5I aldo keto reductase G9272_RS04220 ENOG4105C26 Dehydrogenase G9272_RS04225 ENOG4105CHP RNA polymerase G9272_RS04265 ENOG4105FBW Monooxygenase G9272_RS04270 ENOG4107RSM transcriptional regulator G9272_RS04295 ENOG4105CVP deoxyribo-dipyrimidine photolyase G9272_RS04320 ENOG4105K6V RNA polymerase G9272_RS04325 ENOG4105RNG membrane G9272_RS04335 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G9272_RS04340 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G9272_RS04410 ENOG4105CBC glutamate synthase G9272_RS04415 ENOG4105F2Z 3-oxoadipate enol-lactonase G9272_RS04425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G9272_RS04430 ENOG4105KF0 sporulation and cell division protein, SsgA G9272_RS04480 ENOG4105E39 Enoyl-CoA hydratase G9272_RS04505 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS04575 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G9272_RS04605 ENOG4108IG5 Transcriptional regulator G9272_RS04615 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G9272_RS04620 ENOG4108IG5 Transcriptional regulator G9272_RS04635 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G9272_RS04645 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G9272_RS04665 ENOG4105E2A Dehydrogenase G9272_RS04680 ENOG4107QRI Phosphoketolase G9272_RS04710 ENOG4105F1A Pyruvate formate-lyase G9272_RS04735 ENOG4105D5Q Arginine ornithine antiporter G9272_RS04745 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G9272_RS04755 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G9272_RS04770 ENOG4105C0A alcohol dehydrogenase G9272_RS04780 ENOG4105CCI Myosin-Cross-Reactive Antigen G9272_RS04865 ENOG4107SCK Monooxygenase G9272_RS04885 ENOG4105X7H acyl-CoA dehydrogenase G9272_RS04900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G9272_RS04905 ENOG4105BZU Histidine kinase G9272_RS04915 ENOG4107QRI Phosphoketolase G9272_RS04920 ENOG4108YZG isomerase G9272_RS04945 ENOG4105CMT Dihydroxyacetone kinase G9272_RS04950 ENOG4108UTZ Dihydroxyacetone kinase G9272_RS04955 ENOG4105VDH Dihydroxyacetone kinase G9272_RS04980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9272_RS05005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G9272_RS05040 ENOG4105I82 acetyl xylan esterase G9272_RS05055 ENOG4105FDP GntR family transcriptional regulator G9272_RS05105 ENOG41090CE integral membrane protein G9272_RS05110 ENOG4105CSV Glutaminase G9272_RS05115 ENOG4108IJ0 Aspartate ammonia-lyase G9272_RS05130 ENOG41073TP transcriptional regulator G9272_RS05135 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G9272_RS05145 ENOG4105KJJ Uncharacterized ACR, COG1993 G9272_RS05160 ENOG4105WAB arsR family transcriptional regulator G9272_RS05180 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS05190 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS05230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G9272_RS05245 ENOG4105CHR reductase G9272_RS05250 ENOG4105DRR Transcriptional regulator, GntR family G9272_RS05270 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G9272_RS05280 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS05285 ENOG4105CHR reductase G9272_RS05290 ENOG4108R85 Short chain dehydrogenase G9272_RS05300 ENOG4108UYE Lactoylglutathione lyase G9272_RS05305 ENOG4108IY8 ABC, transporter G9272_RS05310 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9272_RS05315 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G9272_RS05330 ENOG4105GAK amidohydrolase 2 G9272_RS05335 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G9272_RS05340 ENOG4107S73 homocitrate synthase G9272_RS05350 ENOG4108YYC ycei family G9272_RS05355 ENOG4105DRS transport system, permease G9272_RS05395 ENOG4105EMU Dehydrogenase G9272_RS05410 ENOG4105F95 Monooxygenase G9272_RS05420 ENOG4108IG5 Transcriptional regulator G9272_RS05460 ENOG4105BZU Histidine kinase G9272_RS05495 ENOG4105E1F short-chain dehydrogenase reductase G9272_RS05550 ENOG4108N5B 2-phosphosulfolactate phosphatase G9272_RS05555 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS05575 ENOG4108HKT sucrose-6-phosphate hydrolase G9272_RS05585 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator G9272_RS05590 ENOG4105CNN ABC, transporter G9272_RS05595 ENOG4105C2J ABC transporter G9272_RS05600 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS05670 ENOG4105J7D transcriptional regulator G9272_RS05695 ENOG4105CPC Aldo Keto reductase G9272_RS05700 ENOG4107SET aldo keto reductase G9272_RS05765 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS05780 ENOG4105E1F short-chain dehydrogenase reductase G9272_RS05785 ENOG4105F44 Two component transcriptional regulator, winged helix family G9272_RS05790 ENOG4105DHQ Histidine kinase G9272_RS05795 ENOG4105CYP glycoside hydrolase, family G9272_RS05810 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G9272_RS05840 ENOG41082BM Transcriptional regulator, arsr family G9272_RS05845 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9272_RS05865 ENOG4105C3M thioredoxin reductase G9272_RS05875 ENOG4105MSB protein, conserved in bacteria G9272_RS05880 ENOG4105MSB protein, conserved in bacteria G9272_RS05935 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G9272_RS05940 ENOG41073TP transcriptional regulator G9272_RS05945 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G9272_RS05950 ENOG4107V59 shikimate G9272_RS05990 ENOG4108JA1 polyketide synthase G9272_RS05995 ENOG4105D49 3-dehydroquinate synthase G9272_RS06005 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS06015 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G9272_RS06040 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS06045 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS06050 ENOG4105CAN Short-chain dehydrogenase reductase Sdr G9272_RS06055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9272_RS06110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G9272_RS06115 ENOG4107R8N Glycosyl transferase, family 2 G9272_RS06140 ENOG4106F1P AAA ATPase, central domain protein G9272_RS06150 ENOG4105MVE transcriptional regulator G9272_RS06175 ENOG4107R34 abc transporter permease protein G9272_RS06180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS06210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G9272_RS06220 ENOG4108IND Tetr family transcriptional regulator G9272_RS06225 ENOG4105CHR reductase G9272_RS06230 ENOG4105E2R ROK family G9272_RS06240 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) G9272_RS06245 ENOG4105D2N Aldolase G9272_RS06250 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G9272_RS06255 ENOG4105E98 transcriptional regulator DeoR family G9272_RS06265 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G9272_RS06290 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS06300 ENOG4106UW1 Major Facilitator superfamily G9272_RS06325 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS06330 ENOG4105BZU Histidine kinase G9272_RS06345 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G9272_RS06350 ENOG4107PP3 Acetylornithine deacetylase G9272_RS06360 ENOG4105I1F Resistance protein G9272_RS06380 ENOG41060NJ transcriptional regulator G9272_RS06405 ENOG4105C10 Electron transfer flavoprotein G9272_RS06430 ENOG4105PSQ Acyl-transferase G9272_RS06465 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G9272_RS06490 ENOG4105GVJ transcriptional regulator G9272_RS06510 ENOG410841Q phosphoesterase PA-phosphatase related protein G9272_RS06550 ENOG4105C2W permease G9272_RS06570 ENOG4107S46 esterase, PHB depolymerase G9272_RS06585 ENOG4105CSU acyl-Coa dehydrogenase G9272_RS06600 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G9272_RS06605 ENOG4105RD7 BadF BadG BcrA BcrD G9272_RS06615 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G9272_RS06655 ENOG4105VEQ Cold shock protein G9272_RS06670 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G9272_RS06690 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G9272_RS06705 ENOG4105E90 ABC transporter G9272_RS06740 ENOG4105D8K carboxyl transferase G9272_RS06745 ENOG4107RCI amp-dependent synthetase and ligase G9272_RS06750 ENOG4107EEY synthase G9272_RS06780 ENOG4105C1J atp-dependent rna helicase G9272_RS06785 ENOG4105VEQ Cold shock protein G9272_RS06815 ENOG4105CNN ABC, transporter G9272_RS06820 ENOG4105C2J ABC transporter G9272_RS06870 ENOG4107SET aldo keto reductase G9272_RS06885 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G9272_RS06890 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G9272_RS06900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9272_RS06910 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase G9272_RS06935 ENOG4105CQB FAD linked oxidase domain protein G9272_RS06940 ENOG4108JPW Aminotransferase G9272_RS06955 ENOG4105H3G oxidoreductase G9272_RS06965 ENOG4105BZ1 (ABC) transporter G9272_RS06975 ENOG4105CK2 sodium dicarboxylate symporter G9272_RS06990 ENOG4105BZ1 (ABC) transporter G9272_RS06995 ENOG4105BZ1 (ABC) transporter G9272_RS07020 ENOG4105C29 acyl-CoA thioesterase G9272_RS07030 ENOG4105GWZ Roadblock lc7 family protein G9272_RS07060 ENOG4105BZU Histidine kinase G9272_RS07125 ENOG4105CMG Carbohydrate kinase G9272_RS07130 ENOG4105E2R ROK family G9272_RS07140 ENOG4107RR1 TRANSCRIPTIONal G9272_RS07145 ENOG4105C26 Dehydrogenase G9272_RS07245 ENOG4107RN3 metallophosphoesterase G9272_RS07260 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G9272_RS07280 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS07295 ENOG4105DRS transport system, permease G9272_RS07300 ENOG41065HY 1,4-beta-cellobiosidase G9272_RS07310 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS07315 ENOG4106R7G Glycoside hydrolase family 5 G9272_RS07340 ENOG4105C5Q Transcriptional regulator G9272_RS07345 ENOG4105CHR reductase G9272_RS07355 ENOG4105D4Y metalloprotease G9272_RS07395 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G9272_RS07400 ENOG4108Z6Z Transcriptional regulator G9272_RS07410 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS07415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS07425 ENOG4105DAE Methylenetetrahydrofolate reductase G9272_RS07430 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase G9272_RS07440 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS07455 ENOG41061H0 Monooxygenase G9272_RS07490 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G9272_RS07495 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G9272_RS07500 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G9272_RS07540 ENOG4105ECP epimerase G9272_RS07580 ENOG4108VQT Alpha beta hydrolase fold protein G9272_RS07600 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase G9272_RS07620 ENOG4105CNN ABC, transporter G9272_RS07625 ENOG4105C2J ABC transporter G9272_RS07630 ENOG4105F0H myo-inositol catabolism protein G9272_RS07635 ENOG4105D7K pfkb domain protein G9272_RS07645 ENOG4105DH8 myo-inositol catabolism G9272_RS07650 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G9272_RS07655 ENOG4105C26 Dehydrogenase G9272_RS07665 ENOG4107QP6 Xylose isomerase domain protein TIM barrel G9272_RS07680 ENOG4105DFW ABC transporter G9272_RS07690 ENOG4105DFW ABC transporter G9272_RS07695 ENOG4108HWW ABC transporter G9272_RS07705 ENOG4105HHS UPF0256 protein G9272_RS07725 ENOG4105KTE polyketide synthesis cyclase G9272_RS07735 ENOG41079R3 acyl carrier protein G9272_RS07740 ENOG4108PDG Beta-ketoacyl synthase G9272_RS07800 ENOG4105CGS Alpha-glucosidase G9272_RS07835 ENOG4107S91 Sodium hydrogen exchanger G9272_RS07845 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS07880 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS07885 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS07890 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G9272_RS07900 ENOG4108JU3 Alkyl hydroperoxide reductase G9272_RS07905 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) G9272_RS07930 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS07940 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G9272_RS07950 ENOG4105F1K Glutamine amidotransferase G9272_RS07955 ENOG4105CTQ phosphohexokinase G9272_RS07970 ENOG4108HRK Histidine kinase G9272_RS07985 ENOG4108NEV two component transcriptional regulator, LytTR family G9272_RS07995 ENOG4105CIK Amidinotransferase G9272_RS08000 ENOG4105C8Y Acetylornithine aminotransferase G9272_RS08030 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G9272_RS08035 ENOG4108ZJ1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G9272_RS08040 ENOG4105CQM Urea amidohydrolase subunit alpha G9272_RS08045 ENOG4105KI2 Urea amidohydrolase subunit beta G9272_RS08050 ENOG4108YZ9 Urea amidohydrolase subunit gamma G9272_RS08055 ENOG4108Q5F Tetr family transcriptional regulator G9272_RS08105 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G9272_RS08110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G9272_RS08115 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G9272_RS08130 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS08145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS08150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS08180 ENOG4105C83 adenylosuccinate lyase G9272_RS08185 ENOG4108VCA G U mismatch-specific DNA glycosylase G9272_RS08205 ENOG4105BZU Histidine kinase G9272_RS08210 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS08215 ENOG4105DKQ ROK family G9272_RS08220 ENOG4105FDP GntR family transcriptional regulator G9272_RS08225 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G9272_RS08235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9272_RS08275 ENOG4105EYH Exonuclease G9272_RS08280 ENOG4107RH8 nuclease SbcCD subunit D G9272_RS08285 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G9272_RS08305 ENOG4105K4P CoA-binding domain protein G9272_RS08315 ENOG41082SX arsR family transcriptional regulator G9272_RS08340 ENOG4108UW5 maltose o-acetyltransferase G9272_RS08345 ENOG4108Z0R Transferase G9272_RS08365 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G9272_RS08385 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G9272_RS08400 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS08430 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G9272_RS08515 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G9272_RS08520 ENOG4105EP9 oxidoreductase G9272_RS08535 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G9272_RS08540 ENOG4107RRN ABC transporter substrate-binding protein G9272_RS08545 ENOG4105CHR reductase G9272_RS08580 ENOG4105DND Transcriptional regulator G9272_RS08585 ENOG4108Q5Y Membrane G9272_RS08590 ENOG4105CSW GntR family transcriptional regulator G9272_RS08620 ENOG4105NTW Transcriptional regulator G9272_RS08625 ENOG4105CHR reductase G9272_RS08655 ENOG41086KC Transcriptional regulator G9272_RS08660 ENOG4105JAB phenazine biosynthesis protein, phzf family G9272_RS08690 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS08720 ENOG4105F4R Transcriptional regulator mode G9272_RS08725 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G9272_RS08740 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G9272_RS08760 ENOG4108UW8 fha domain-containing protein G9272_RS08810 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G9272_RS08820 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G9272_RS08830 ENOG4105E09 nadh pyrophosphatase G9272_RS08835 ENOG4108UQS dipeptidase G9272_RS08845 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G9272_RS08850 ENOG4105BZU Histidine kinase G9272_RS08855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9272_RS08860 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9272_RS08920 ENOG4105CFM UPF0317 protein G9272_RS08925 ENOG4105E7W lamb ycsf family protein G9272_RS08930 ENOG4105P4J Allophanate hydrolase, subunit 1 G9272_RS08935 ENOG4107R7A Allophanate hydrolase subunit 2 G9272_RS08950 ENOG4108MJN Glycosyl Transferase G9272_RS08965 ENOG4105JXB ankyrin repeat-containing protein G9272_RS08985 ENOG4108VW9 Membrane G9272_RS08995 ENOG4105DEU major facilitator superfamily G9272_RS09000 ENOG4105Q70 G9272_RS09010 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) G9272_RS09020 ENOG4105EW9 transcriptional regulator AsnC family G9272_RS09030 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS09055 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G9272_RS09080 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G9272_RS09085 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase G9272_RS09090 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G9272_RS09095 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G9272_RS09110 ENOG4105ECP epimerase G9272_RS09115 ENOG4105E2R ROK family G9272_RS09120 ENOG4106UW1 Major Facilitator superfamily G9272_RS09130 ENOG4105C2W permease G9272_RS09160 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 G9272_RS09165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9272_RS09175 ENOG4105F38 ABC transporter, permease G9272_RS09185 ENOG4108TZY GntR Family Transcriptional Regulator G9272_RS09195 ENOG4105CUB amino acid G9272_RS09215 ENOG4105DKT Transcriptional regulator G9272_RS09220 ENOG4105DJV ribulose-phosphate 3-epimerase G9272_RS09225 ENOG4105EYF MMPL domain protein G9272_RS09230 ENOG4105CDH Citrulline--aspartate ligase G9272_RS09240 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G9272_RS09255 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G9272_RS09265 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) G9272_RS09270 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G9272_RS09280 ENOG4105SKN orotidine 5''-phosphate decarboxylase G9272_RS09285 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G9272_RS09290 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G9272_RS09295 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G9272_RS09305 ENOG4105CD3 dihydroorotase G9272_RS09310 ENOG4105CXT aspartate transcarbamylase G9272_RS09315 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G9272_RS09325 ENOG410803B Involved in the transcription termination process (By similarity) G9272_RS09330 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G9272_RS09335 ENOG4105DC7 peptidase M24 G9272_RS09345 ENOG4105D49 3-dehydroquinate synthase G9272_RS09350 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G9272_RS09355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G9272_RS09370 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G9272_RS09375 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G9272_RS09390 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G9272_RS09405 ENOG4105CUT histidyl-tRNA synthetase G9272_RS09415 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) G9272_RS09420 ENOG4105C99 atpase involved in dna repair G9272_RS09425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G9272_RS09430 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G9272_RS09435 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G9272_RS09440 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G9272_RS09450 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G9272_RS09455 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G9272_RS09460 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G9272_RS09465 ENOG4105CDY transcriptional regulatory protein G9272_RS09470 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G9272_RS09475 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G9272_RS09485 ENOG4105E2K Glycosyl transferase (Group 1 G9272_RS09490 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase G9272_RS09520 ENOG4105C22 threonyL-tRNA synthetase G9272_RS09535 ENOG4108IRC dna polymerase iii G9272_RS09555 ENOG4105EKC G9272_RS09565 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9272_RS09570 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G9272_RS09575 ENOG410769Z extracellular solute-binding protein family 1 G9272_RS09590 ENOG4105KF0 sporulation and cell division protein, SsgA G9272_RS09675 ENOG4105RNG membrane G9272_RS09680 ENOG4105K6V RNA polymerase G9272_RS09700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G9272_RS09705 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G9272_RS09720 ENOG4105D01 (LipO)protein G9272_RS09725 ENOG4108UMI ABC transporter, permease G9272_RS09730 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G9272_RS09760 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS09765 ENOG4105C57 major facilitator superfamily G9272_RS09770 ENOG4105RJZ Transcriptional regulator G9272_RS09780 ENOG4105CH7 arginosuccinase G9272_RS09805 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9272_RS09820 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) G9272_RS09825 ENOG4105C8Y Acetylornithine aminotransferase G9272_RS09830 ENOG4105CAS nag kinase G9272_RS09835 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G9272_RS09840 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G9272_RS09875 ENOG4105T38 integral membrane protein G9272_RS09885 ENOG4105F32 YngK protein G9272_RS09915 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G9272_RS09920 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G9272_RS09925 ENOG4105BZU Histidine kinase G9272_RS09930 ENOG4108RWN rrna methyltransferase G9272_RS09935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G9272_RS09940 ENOG41084BS 50S ribosomal protein L35 G9272_RS09945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G9272_RS09980 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G9272_RS09985 ENOG4105C26 Dehydrogenase G9272_RS09990 ENOG4105C5F glutamine synthetase G9272_RS10000 ENOG4108Z86 Glutamine amidotransferase G9272_RS10015 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G9272_RS10025 ENOG4108HQS Glycine betaine G9272_RS10030 ENOG4108IJ7 Glycine betaine G9272_RS10035 ENOG4105HFS 5'-3' exonuclease G9272_RS10080 ENOG4105D3G Pseudouridine synthase G9272_RS10110 ENOG4105MKU Transcriptional regulator G9272_RS10145 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G9272_RS10150 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G9272_RS10180 ENOG4108V1T peptidylprolyl cis-trans isomerase G9272_RS10185 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) G9272_RS10195 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS10200 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G9272_RS10205 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G9272_RS10215 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) G9272_RS10220 ENOG4105E5F proteasome G9272_RS10225 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) G9272_RS10255 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS10260 ENOG4105DEF Extracellular solute-binding protein, family 5 G9272_RS10265 ENOG4108J59 Extracellular solute-binding protein, family 5 G9272_RS10270 ENOG4107URF beta-phospho-glucomutase G9272_RS10275 ENOG4105C3R Methionine synthase G9272_RS10280 ENOG4108K8U Glycerol operon regulatory protein G9272_RS10285 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9272_RS10290 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9272_RS10295 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G9272_RS10300 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) G9272_RS10310 ENOG4105C2J ABC transporter G9272_RS10320 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G9272_RS10325 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) G9272_RS10335 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G9272_RS10345 ENOG4108JQ9 ABC transporter G9272_RS10360 ENOG4108I5U Uridine phosphorylase G9272_RS10365 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G9272_RS10370 ENOG4105JXH GntR family transcriptional regulator G9272_RS10380 ENOG4105C8N cysteinyl-tRNA synthetase G9272_RS10395 ENOG4108RH7 phosphoglycerate mutase G9272_RS10400 ENOG4105D7N magnesium and cobalt transport protein CorA G9272_RS10410 ENOG4105DYW oxidoreductase G9272_RS10415 ENOG4105CPC Aldo Keto reductase G9272_RS10435 ENOG4105S2J secreted protein G9272_RS10445 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G9272_RS10470 ENOG4105CD8 aminopeptidase N G9272_RS10475 ENOG4105K5B UPF0225 protein G9272_RS10480 ENOG4105C6F GntR Family Transcriptional Regulator G9272_RS10485 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G9272_RS10490 ENOG4105C6Z Gluconate G9272_RS10495 ENOG4105CHR reductase G9272_RS10500 ENOG4105CPQ Dehydrogenase G9272_RS10525 ENOG4105PTV Nudix Hydrolase G9272_RS10530 ENOG4105VG5 Membrane G9272_RS10535 ENOG4105JP4 Inner membrane protein yidG G9272_RS10560 ENOG4108IG5 Transcriptional regulator G9272_RS10565 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS10600 ENOG4108Z4X TRANSCRIPTIONal G9272_RS10620 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS10630 ENOG4108ZHR arsR family transcriptional regulator G9272_RS10670 ENOG4105D4T Citrate transporter G9272_RS10675 ENOG4108J2R molybdopterin oxidoreductase G9272_RS10680 ENOG4108SGK Tetr family transcriptional regulator G9272_RS10690 ENOG4105F1J Homogentisate 1,2-dioxygenase G9272_RS10715 ENOG4105RNG membrane G9272_RS10720 ENOG4105K6V RNA polymerase G9272_RS10735 ENOG41061MD high-affinity nickel-transporter G9272_RS10740 ENOG4105D9P serine threonine protein kinase G9272_RS10745 ENOG4108TCJ secreted hydrolase G9272_RS10750 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G9272_RS10780 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G9272_RS10795 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS10820 ENOG4108Z2K Cupin 2, conserved barrel domain protein G9272_RS10825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G9272_RS10830 ENOG4105C0B DNA polymerase III (alpha subunit) G9272_RS10845 ENOG4106NMR serine protease G9272_RS10880 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G9272_RS10885 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS10890 ENOG4105C57 major facilitator superfamily G9272_RS10900 ENOG410841Q phosphoesterase PA-phosphatase related protein G9272_RS10920 ENOG4105MS9 Resuscitation-promoting factor G9272_RS10935 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G9272_RS10945 ENOG4105CAT Cytidine monophosphate kinase G9272_RS10975 ENOG41065RQ ADP-ribosylation crystallin J1 G9272_RS10985 ENOG4105FE9 pseudouridine synthase G9272_RS10990 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G9272_RS10995 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G9272_RS11010 ENOG4105DCF alanine dehydrogenase G9272_RS11020 ENOG4108YZ4 nudix hydrolase G9272_RS11025 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G9272_RS11030 ENOG4105BZP glycoside hydrolase 15-related G9272_RS11050 ENOG4107RJ7 Glycosyl transferase (Group 1 G9272_RS11060 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G9272_RS11065 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G9272_RS11085 ENOG4105E0A ABC, transporter G9272_RS11090 ENOG4105TVJ transport system, permease G9272_RS11095 ENOG4105DQ5 transport system permease protein G9272_RS11100 ENOG4105DSU hydrolase G9272_RS11135 ENOG4108VX5 3-methyladenine DNA glycosylase G9272_RS11145 ENOG4108V1U phospholipid-binding protein G9272_RS11165 ENOG4105DKW ABC transporter G9272_RS11185 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS11190 ENOG4108XG2 Histidine kinase G9272_RS11195 ENOG4105EMU Dehydrogenase G9272_RS11200 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G9272_RS11210 ENOG4105IDI abc transporter atp-binding protein G9272_RS11220 ENOG4105EAC phosphoserine phosphatase G9272_RS11240 ENOG4107YCY Transcriptional regulator G9272_RS11255 ENOG4105CHR reductase G9272_RS11270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G9272_RS11290 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G9272_RS11295 ENOG4107QN1 sodium solute G9272_RS11340 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G9272_RS11360 ENOG4105D22 carbon starvation protein G9272_RS11380 ENOG4105BZP glycoside hydrolase 15-related G9272_RS11385 ENOG4105CHR reductase G9272_RS11410 ENOG4105VBF alkaline shock protein G9272_RS11430 ENOG4105C5H ABC transporter G9272_RS11450 ENOG4107W7X Aldolase G9272_RS11470 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G9272_RS11475 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G9272_RS11480 ENOG4105CTK cobaltochelatase, cobn subunit G9272_RS11490 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G9272_RS11495 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G9272_RS11510 ENOG4105CIA precorrin-4 C(11)-methyltransferase G9272_RS11520 ENOG4105E4R Precorrin-3B C17-methyltransferase G9272_RS11525 ENOG41081F0 Precorrin-8x methylmutase G9272_RS11530 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G9272_RS11555 ENOG4105EAD ABC transporter G9272_RS11560 ENOG4106PMH Extracellular solute-binding protein family 3 G9272_RS11565 ENOG4105C5R Aminotransferase G9272_RS11575 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase G9272_RS11580 ENOG4108JPW Aminotransferase G9272_RS11585 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) G9272_RS11590 ENOG4105EV8 ectoine hydroxylase G9272_RS11595 ENOG4105C9B Cysteine desulfurase G9272_RS11620 ENOG4107258 Transcriptional regulator G9272_RS11630 ENOG4105CJN penicillin-binding protein G9272_RS11635 ENOG4105C7N Xanthine uracil vitamin C permease G9272_RS11640 ENOG4105NAF rna polymerase sigma factor G9272_RS11650 ENOG4108J21 pectate lyase G9272_RS11675 ENOG4105NBR Pectinesterase G9272_RS11680 ENOG4108J20 pectate lyase G9272_RS11685 ENOG4107TDE lipolytic protein G-D-S-L family G9272_RS11715 ENOG4108J20 pectate lyase G9272_RS11725 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS11735 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9272_RS11740 ENOG4105DRR Transcriptional regulator, GntR family G9272_RS11745 ENOG4108RQ5 Beta-lactamase domain-containing protein G9272_RS11770 ENOG4105E9Z Nad-dependent epimerase dehydratase G9272_RS11775 ENOG4105E98 transcriptional regulator DeoR family G9272_RS11785 ENOG4105XEA Tetr family transcriptional regulator G9272_RS11800 ENOG4107XBN GntR Family Transcriptional Regulator G9272_RS11805 ENOG41060BG Tetr family transcriptional regulator G9272_RS11815 ENOG4106NZI LysR family Transcriptional regulator G9272_RS11820 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G9272_RS11865 ENOG4105EAB amino acid AbC transporter G9272_RS11870 ENOG4105EAD ABC transporter G9272_RS11875 ENOG4105CDA abc transporter atp-binding protein G9272_RS11880 ENOG4105MWK D-amino acid dehydrogenase, small subunit G9272_RS11895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9272_RS11905 ENOG4105NAF rna polymerase sigma factor G9272_RS11955 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) G9272_RS11970 ENOG410814C multidrug resistance protein G9272_RS11980 ENOG4105VG1 fes assembly suf system protein G9272_RS11985 ENOG4108UNV SUF system FeS assembly protein, NifU family G9272_RS11990 ENOG4105C9B Cysteine desulfurase G9272_RS11995 ENOG4105C3K feS assembly ATPase SufC G9272_RS12005 ENOG4105JRK feS assembly protein SufD G9272_RS12020 ENOG4108AQF aminoglycoside N(3)-acetyltransferase G9272_RS12025 ENOG4105CJ1 ABC, transporter G9272_RS12035 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) G9272_RS12055 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G9272_RS12065 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G9272_RS12080 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) G9272_RS12090 ENOG4107QP8 phosphohexose isomerase G9272_RS12105 ENOG4105CP7 Triose-phosphate isomerase G9272_RS12110 ENOG4105BZA Phosphoglycerate kinase G9272_RS12115 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G9272_RS12125 ENOG4105CIE May be required for sporulation (By similarity) G9272_RS12130 ENOG4105CHW UPF0052 protein G9272_RS12135 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G9272_RS12140 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G9272_RS12165 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G9272_RS12175 ENOG4107VMB Beta-lactamase domain protein G9272_RS12180 ENOG4107R0W ABC transporter G9272_RS12185 ENOG4105E5Q amino acid AbC transporter G9272_RS12195 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G9272_RS12200 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G9272_RS12205 ENOG4105CSH Transporter G9272_RS12230 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G9272_RS12235 ENOG4105BZU Histidine kinase G9272_RS12240 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G9272_RS12245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G9272_RS12250 ENOG4105DXI Major Facilitator superfamily G9272_RS12260 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) G9272_RS12265 ENOG4105D7K pfkb domain protein G9272_RS12270 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS12275 ENOG4105D7N magnesium and cobalt transport protein CorA G9272_RS12305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS12310 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9272_RS12395 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G9272_RS12400 ENOG4108WYP Transcriptional regulator G9272_RS12425 ENOG4108D32 Methyltransferase G9272_RS12440 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G9272_RS12450 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G9272_RS12455 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS12460 ENOG4105CQ7 ATP-dependent helicase G9272_RS12500 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) G9272_RS12520 ENOG4105C32 Amino acid ABC transporter (Permease) G9272_RS12525 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G9272_RS12530 ENOG4105C0Z ABC transporter G9272_RS12535 ENOG4108IV0 ABC, transporter G9272_RS12565 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic G9272_RS12585 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G9272_RS12595 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G9272_RS12605 ENOG4105E39 Enoyl-CoA hydratase G9272_RS12620 ENOG4105EA8 2-Nitropropane dioxygenase G9272_RS12625 ENOG4105F2C Acetyl-CoA acetyltransferase G9272_RS12630 ENOG4108RZE Tetr family transcriptional regulator G9272_RS12635 ENOG4105CHR reductase G9272_RS12640 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS12660 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G9272_RS12665 ENOG41090B9 response to stress G9272_RS12670 ENOG4105MUA Resistance protein G9272_RS12685 ENOG4105CBC glutamate synthase G9272_RS12695 ENOG41065RQ ADP-ribosylation crystallin J1 G9272_RS12715 ENOG4108RVA ribokinase G9272_RS12720 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS12730 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G9272_RS12740 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G9272_RS12745 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G9272_RS12755 ENOG4105DK0 Indole-3-glycerol phosphate synthase G9272_RS12780 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G9272_RS12805 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G9272_RS12810 ENOG4108176 endoribonuclease L-psp G9272_RS12815 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G9272_RS12820 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G9272_RS12830 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G9272_RS12835 ENOG4105CIH Imidazole acetol-phosphate transaminase G9272_RS12840 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G9272_RS12860 ENOG4108Z66 YbaK ebsC protein G9272_RS12890 ENOG4105C0B DNA polymerase III (alpha subunit) G9272_RS12925 ENOG4105CHR reductase G9272_RS12935 ENOG41082BV acetyltransferase G9272_RS12945 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G9272_RS12955 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G9272_RS12960 ENOG4107VQS DivIVA family G9272_RS12970 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G9272_RS12975 ENOG4105DFA alanine racemase domain protein G9272_RS12980 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G9272_RS12985 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G9272_RS12990 ENOG4105ME9 cell division protein FtsQ G9272_RS12995 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G9272_RS13005 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G9272_RS13010 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G9272_RS13020 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G9272_RS13025 ENOG4105CJN penicillin-binding protein G9272_RS13035 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G9272_RS13045 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G9272_RS13075 ENOG4105CDA abc transporter atp-binding protein G9272_RS13085 ENOG4107Z3H Transcriptional regulator, TetR family G9272_RS13095 ENOG4105EWK phytoene G9272_RS13110 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G9272_RS13115 ENOG4105KYH transcriptional regulatory protein G9272_RS13140 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G9272_RS13150 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G9272_RS13160 ENOG4108UQY Iron-storage protein G9272_RS13170 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G9272_RS13185 ENOG4105CTQ phosphohexokinase G9272_RS13220 ENOG4105DKQ ROK family G9272_RS13230 ENOG4105D0U Arsenite-activated ATPase (ArsA) G9272_RS13260 ENOG4105UQX Mate efflux family protein G9272_RS13305 ENOG4105C9B Cysteine desulfurase G9272_RS13310 ENOG4108I0Q anthranilate phosphoribosyltransferase G9272_RS13315 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G9272_RS13320 ENOG4107EUI c reductase, iron-sulfur G9272_RS13325 ENOG4107UDY cytochrome C G9272_RS13330 ENOG4105CCU oxidase (Subunit III) G9272_RS13340 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G9272_RS13345 ENOG4105MCD Part of cytochrome c oxidase, its function is G9272_RS13350 ENOG4105BZ9 Cytochrome C oxidase, subunit I G9272_RS13355 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G9272_RS13365 ENOG4107T4Z adenosine kinase G9272_RS13385 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G9272_RS13390 ENOG4108762 serine threonine protein kinase G9272_RS13400 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS13405 ENOG4105BZU Histidine kinase G9272_RS13435 ENOG4108YZT Adenosylcobinamide kinase G9272_RS13445 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G9272_RS13450 ENOG4105CRK lysyL-tRNA synthetase G9272_RS13465 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G9272_RS13475 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G9272_RS13495 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G9272_RS13545 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G9272_RS13550 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G9272_RS13570 ENOG4105C5F glutamine synthetase G9272_RS13605 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS13630 ENOG4105D0M Protease HtpX homolog G9272_RS13665 ENOG4108222 arsenate reductase G9272_RS13675 ENOG4106SPC secreted protein G9272_RS13680 ENOG4107R5B glutamine synthetase G9272_RS13690 ENOG4107NHD transcriptional regulator G9272_RS13705 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS13740 ENOG41060BG Tetr family transcriptional regulator G9272_RS13770 ENOG4105CG3 alpha amylase, catalytic region G9272_RS13775 ENOG4105EG2 ABC transporter, permease G9272_RS13780 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component G9272_RS13790 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS13800 ENOG4107RSM transcriptional regulator G9272_RS13805 ENOG4105FDR Membrane G9272_RS13810 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G9272_RS13825 ENOG4105C5F glutamine synthetase G9272_RS13830 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9272_RS13840 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR G9272_RS13855 ENOG41081JD Transcriptional regulator G9272_RS13875 ENOG4105C4K Nad synthetase G9272_RS13895 ENOG4105F27 Major Facilitator G9272_RS13910 ENOG4105C57 major facilitator superfamily G9272_RS13915 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G9272_RS13935 ENOG4107XZ0 Peptidase M50 G9272_RS13985 ENOG4105EHG Permease protein G9272_RS13990 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G9272_RS14000 ENOG4105DBE peroxidase G9272_RS14010 ENOG4106A0S G9272_RS14020 ENOG4105YIP Tetr family transcriptional regulator G9272_RS14030 ENOG4105C2C drug resistance transporter, Bcr CflA G9272_RS14035 ENOG4107S1E Beta-lactamase G9272_RS14045 ENOG4105DGI Alkaline phosphatase G9272_RS14055 ENOG4105DZ1 carboxypeptidase G9272_RS14065 ENOG4105C19 ABC transporter G9272_RS14075 ENOG4108VGI doxx family G9272_RS14110 ENOG4105C85 amino acid G9272_RS14130 ENOG4107XFJ UPF0246 protein G9272_RS14135 ENOG4108UHU Aldolase G9272_RS14150 ENOG4105EGD dinuclear metal center protein, YbgI family G9272_RS14165 ENOG4105CHR reductase G9272_RS14185 ENOG4108S01 response regulator G9272_RS14220 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G9272_RS14230 ENOG4105DYW oxidoreductase G9272_RS14245 ENOG4107QVI Methyltransferase, type 11 G9272_RS14250 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G9272_RS14255 ENOG4108SGK Tetr family transcriptional regulator G9272_RS14295 ENOG4105D9P serine threonine protein kinase G9272_RS14315 ENOG4108JJB ABC transporter G9272_RS14330 ENOG4105XPP Protein of unknown function (DUF1275) G9272_RS14345 ENOG4106A3M Cytochrome p-450 G9272_RS14350 ENOG4105F2C Acetyl-CoA acetyltransferase G9272_RS14505 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G9272_RS14510 ENOG4105D7V transposase G9272_RS14525 ENOG4105ED2 Beta-lactamase G9272_RS14580 ENOG41068SY G9272_RS14590 ENOG4105BZ4 penicillin-binding protein G9272_RS14605 ENOG4105DAX Pfam:DUF2983 G9272_RS14650 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G9272_RS14655 ENOG4105EYW Ion transport protein G9272_RS14685 ENOG4108FN7 Aldo keto reductase G9272_RS14690 ENOG4105VUF Transcriptional regulator G9272_RS14725 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9272_RS14745 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G9272_RS14750 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G9272_RS14755 ENOG4105NGS secreted protein G9272_RS14760 ENOG4105N14 lysine exporter protein LysE YggA G9272_RS14775 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G9272_RS14805 ENOG41062B0 ABC transporter, permease G9272_RS14810 ENOG4107R9N ABC transporter G9272_RS14815 ENOG4105C2J ABC transporter G9272_RS14820 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G9272_RS14825 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS14835 ENOG4105CXK mandelate racemase muconate lactonizing G9272_RS14850 ENOG4105DFW ABC transporter G9272_RS14855 ENOG4105C2J ABC transporter G9272_RS14860 ENOG4108HWW ABC transporter G9272_RS14865 ENOG4105CIH Imidazole acetol-phosphate transaminase G9272_RS14870 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase G9272_RS14925 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G9272_RS14955 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G9272_RS14960 ENOG4105J4Q Transcriptional regulator G9272_RS14980 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS14985 ENOG4105D8K carboxyl transferase G9272_RS15000 ENOG4106F1P AAA ATPase, central domain protein G9272_RS15015 ENOG4105DFF Rod shape-determining protein mreb G9272_RS15020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G9272_RS15050 ENOG4105CIH Imidazole acetol-phosphate transaminase G9272_RS15115 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G9272_RS15120 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G9272_RS15135 ENOG4105EB3 Histidine kinase G9272_RS15150 ENOG4105DME alpha-galactosidase G9272_RS15155 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS15190 ENOG4105CBD Diacylglycerol kinase G9272_RS15205 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS15210 ENOG4105EX0 alpha-galactosidase G9272_RS15215 ENOG4106F59 XRE family Transcriptional regulator G9272_RS15220 ENOG4105XUP Phage derived protein Gp49-like (DUF891) G9272_RS15305 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G9272_RS15315 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G9272_RS15325 ENOG4107GZ4 SanA protein G9272_RS15330 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G9272_RS15340 ENOG4105C57 major facilitator superfamily G9272_RS15395 ENOG4107QZF nitrite reductase NADPH large subunit G9272_RS15405 ENOG4105DHQ Histidine kinase G9272_RS15415 ENOG4107B2H carbonic anhydrase G9272_RS15425 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G9272_RS15455 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G9272_RS15465 ENOG4105BZ1 (ABC) transporter G9272_RS15470 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G9272_RS15475 ENOG4105E2R ROK family G9272_RS15520 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G9272_RS15530 ENOG4108FN7 Aldo keto reductase G9272_RS15555 ENOG4108VQR secreted hydrolase G9272_RS15560 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G9272_RS15570 ENOG4105FDK ABC transporter G9272_RS15575 ENOG4105FAV ABC, transporter G9272_RS15590 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G9272_RS15595 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G9272_RS15645 ENOG4105NAF rna polymerase sigma factor G9272_RS15655 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS15660 ENOG4105BZU Histidine kinase G9272_RS15665 ENOG4105EYF MMPL domain protein G9272_RS15675 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G9272_RS15680 ENOG4105D4Y metalloprotease G9272_RS15710 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G9272_RS15745 ENOG4105MSB protein, conserved in bacteria G9272_RS15755 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G9272_RS15770 ENOG4105EQX glucarate dehydratase G9272_RS15775 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G9272_RS15790 ENOG4105E08 Glycoside hydrolase, family 9 G9272_RS15820 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G9272_RS15825 ENOG4107YU2 histidine triad (hIT) protein G9272_RS15830 ENOG4107RE3 peptidase, S41 G9272_RS15855 ENOG4105EA8 2-Nitropropane dioxygenase G9272_RS15860 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G9272_RS15865 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G9272_RS15900 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G9272_RS15905 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) G9272_RS15925 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G9272_RS15935 ENOG4105EPR degv family G9272_RS15945 ENOG4105C8T Leucyl-tRNA synthetase G9272_RS15955 ENOG4107QIZ NADH dehydrogenase G9272_RS15985 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G9272_RS15990 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G9272_RS16000 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G9272_RS16015 ENOG4105D0M Protease HtpX homolog G9272_RS16030 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G9272_RS16040 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G9272_RS16050 ENOG4105K64 Glycosyl transferase, family 2 G9272_RS16070 ENOG4105DGI Alkaline phosphatase G9272_RS16080 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G9272_RS16085 ENOG4105K46 50S ribosomal protein l27 G9272_RS16090 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G9272_RS16135 ENOG4105J5G Transferase hexapeptide repeat containing protein G9272_RS16150 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G9272_RS16170 ENOG4108IJ1 Dehydrogenase G9272_RS16180 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G9272_RS16185 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G9272_RS16190 ENOG4105C03 ribonuclease G9272_RS16225 ENOG4105CNI cell division protein FtsW G9272_RS16230 ENOG4105CJN penicillin-binding protein G9272_RS16245 ENOG4105DFF Rod shape-determining protein mreb G9272_RS16250 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G9272_RS16260 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G9272_RS16265 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G9272_RS16275 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G9272_RS16280 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G9272_RS16285 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G9272_RS16290 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G9272_RS16310 ENOG4108TGC Acyltransferase G9272_RS16340 ENOG4105C85 amino acid G9272_RS16345 ENOG4108UGD Serine Threonine protein kinase G9272_RS16360 ENOG4105E2R ROK family G9272_RS16370 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G9272_RS16375 ENOG4105E2Y ABC, transporter G9272_RS16390 ENOG4105C85 amino acid G9272_RS16395 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G9272_RS16410 ENOG4105ENE Histidine kinase G9272_RS16415 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS16425 ENOG4105MC2 DSBA oxidoreductase G9272_RS16475 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G9272_RS16505 ENOG4108KTG Membrane protein, drug metabolite transporter G9272_RS16510 ENOG4108ZT1 Transcriptional regulator G9272_RS16540 ENOG4105D8X mechanosensitive ion channel G9272_RS16545 ENOG4105E2R ROK family G9272_RS16560 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9272_RS16565 ENOG4105F8D glycoside hydrolase family 4 G9272_RS16580 ENOG4105CT1 (ABC) transporter G9272_RS16610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G9272_RS16655 ENOG4105VHU single-stranded DNA-binding protein G9272_RS16675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G9272_RS16900 ENOG4106S9K Transcriptional regulator G9272_RS16920 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G9272_RS16925 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G9272_RS17000 ENOG4105D3Q Sugar transferase G9272_RS17010 ENOG4105CJR Integral membrane protein (MviN G9272_RS17050 ENOG4105S2J secreted protein G9272_RS17050 ENOG4105S2J secreted protein G9272_RS17105 ENOG4105C26 Dehydrogenase G9272_RS17110 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G9272_RS17115 ENOG4105DH8 myo-inositol catabolism G9272_RS17125 ENOG4105EDK PfkB domain protein G9272_RS17130 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G9272_RS17155 ENOG4107R13 MMPL domain protein G9272_RS17180 ENOG4105C7H Helicase, RecD TraA family G9272_RS17190 ENOG4105C2J ABC transporter G9272_RS17195 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9272_RS17200 ENOG4108RVA ribokinase G9272_RS17205 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G9272_RS17230 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS17255 ENOG4107R11 Transcriptional regulator G9272_RS17265 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G9272_RS17270 ENOG4108594 Permease of the drug metabolite transporter G9272_RS17280 ENOG4105D17 glycoside hydrolase, family 3 domain protein G9272_RS17290 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS17295 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G9272_RS17300 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS17340 ENOG4105EDW glycosyl transferase, family 39 G9272_RS17345 ENOG4108K8S endonuclease I G9272_RS17360 ENOG4105C7K acetolactate synthase G9272_RS17370 ENOG4105CK7 Sodium proline symporter G9272_RS17380 ENOG4108XFF G9272_RS17385 ENOG4105C29 acyl-CoA thioesterase G9272_RS17400 ENOG4107QX3 carboxylase G9272_RS17410 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G9272_RS17415 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS17430 ENOG4105DY8 decarboxylase G9272_RS17435 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) G9272_RS17445 ENOG4105DUU IucA IucC family protein G9272_RS17465 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G9272_RS17485 ENOG4105ECQ AraC Family Transcriptional Regulator G9272_RS17490 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G9272_RS17505 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS17520 ENOG4105DRS transport system, permease G9272_RS17540 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 G9272_RS17550 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G9272_RS17555 ENOG4105EPJ extracellular solute-binding protein family 1 G9272_RS17560 ENOG4108NNZ chitinase G9272_RS17565 ENOG410804D Sensor Signal Transduction Histidine Kinase G9272_RS17570 ENOG4108RQS Two component transcriptional regulator (Winged helix family G9272_RS17580 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G9272_RS17595 ENOG4105CVJ phosphoglycerate mutase G9272_RS17640 ENOG4105BZU Histidine kinase G9272_RS17645 ENOG4105DEN Luciferase family G9272_RS17670 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G9272_RS17710 ENOG4105J5T Amp-dependent synthetase and ligase G9272_RS17720 ENOG4108M1A Chitin-binding protein G9272_RS17750 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G9272_RS17780 ENOG4105D9R oxidoreductase G9272_RS17785 ENOG41090KN UPF0303 protein G9272_RS17815 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G9272_RS17825 ENOG4108U4N (sortase) family G9272_RS17855 ENOG4105NI8 Cytosine-specific methyltransferase G9272_RS17880 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G9272_RS17950 ENOG4105EMN RNA polymerase sigma factor G9272_RS17990 ENOG4107QNK )-transporter G9272_RS17995 ENOG4106BRA Membrane G9272_RS18010 ENOG4108IUW ABC transporter G9272_RS18025 ENOG4105BZ4 penicillin-binding protein G9272_RS18055 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G9272_RS18065 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G9272_RS18105 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS18110 ENOG4108RWI nicotinamidase G9272_RS18120 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G9272_RS18130 ENOG4105C85 amino acid G9272_RS18165 ENOG4105KF0 sporulation and cell division protein, SsgA G9272_RS18170 ENOG4105CQB FAD linked oxidase domain protein G9272_RS18180 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase G9272_RS18190 ENOG4105E90 ABC transporter G9272_RS18195 ENOG4108IJ8 ABC transporter G9272_RS18200 ENOG4105E90 ABC transporter G9272_RS18225 ENOG41086VY Fic/DOC family G9272_RS18295 ENOG4105E2D ec 3.2.1.52 G9272_RS18320 ENOG4108UJU UPF0301 protein G9272_RS18325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G9272_RS18330 ENOG4108426 dNA-binding protein G9272_RS18340 ENOG4105EEM helicase G9272_RS18365 ENOG4105DQQ Major facilitator superfamily MFS_1 G9272_RS18385 ENOG4108JP0 extracellular solute-binding protein family 1 G9272_RS18400 ENOG4105CJQ hydrolase, family 31 G9272_RS18420 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G9272_RS18425 ENOG4105CN1 protease G9272_RS18435 ENOG4105CAK Cell division ATP-binding protein ftsE G9272_RS18450 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G9272_RS18455 ENOG4108QVN serine threonine protein kinase G9272_RS18460 ENOG4108UGD Serine Threonine protein kinase G9272_RS18470 ENOG4105EPJ extracellular solute-binding protein family 1 G9272_RS18480 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G9272_RS18485 ENOG4107SJB teichoic acid biosynthesis G9272_RS18490 ENOG4107SJB teichoic acid biosynthesis G9272_RS18510 ENOG4108ZHJ Organic hydroperoxide resistance protein G9272_RS18515 ENOG4105K56 Transcriptional regulator G9272_RS18545 ENOG4105EY8 ABC transporter G9272_RS18550 ENOG4105C7I Dehydrogenase G9272_RS18575 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G9272_RS18585 ENOG4105T0Z Conserved Protein G9272_RS18590 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS18595 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G9272_RS18605 ENOG4105G3P Lipoprotein lpqB G9272_RS18610 ENOG4105BZU Histidine kinase G9272_RS18615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS18625 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G9272_RS18640 ENOG4108WQ6 secreted protein G9272_RS18645 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G9272_RS18685 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G9272_RS18695 ENOG4105EIP mannose-6-phosphate isomerase G9272_RS18705 ENOG4105W49 UPF0434 protein G9272_RS18710 ENOG4107QKV phosphomannomutase G9272_RS18735 ENOG4107RGC Glycosyl transferase, family 2 G9272_RS18740 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G9272_RS18755 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G9272_RS18765 ENOG4107V9E glucose-1-phosphate thymidylyltransferase G9272_RS18780 ENOG4108KGH TRANSCRIPTIONal G9272_RS18785 ENOG4108KGH TRANSCRIPTIONal G9272_RS18790 ENOG4108KGH TRANSCRIPTIONal G9272_RS18810 ENOG4108KGH TRANSCRIPTIONal G9272_RS18825 ENOG4105C6Y Udp-glucose 6-dehydrogenase G9272_RS18850 ENOG4108Z6Z Transcriptional regulator G9272_RS18855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G9272_RS18865 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G9272_RS18880 ENOG41065SU Two-component system sensor kinase G9272_RS18885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS18890 ENOG4105DUX Transporter G9272_RS18920 ENOG41082AN stage II sporulation protein G9272_RS18925 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS18940 ENOG4105CI2 imidazolone-5-propionate hydrolase G9272_RS18955 ENOG4105CGP Urocanate hydratase G9272_RS18990 ENOG4105C84 Histidine ammonia-lyase G9272_RS18995 ENOG4108IJ8 ABC transporter G9272_RS19000 ENOG4105R40 Glycine betaine carnitine choline G9272_RS19005 ENOG4105E90 ABC transporter G9272_RS19020 ENOG4105EMU Dehydrogenase G9272_RS19040 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS19075 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS19080 ENOG4107RBB ABC transporter, permease G9272_RS19085 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G9272_RS19090 ENOG4105CEP NADH dehydrogenase G9272_RS19110 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G9272_RS19185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS19190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS19195 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS19205 ENOG4107QN1 sodium solute G9272_RS19215 ENOG4105CPC Aldo Keto reductase G9272_RS19250 ENOG4108ZGX Histidine kinase G9272_RS19260 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G9272_RS19265 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G9272_RS19270 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G9272_RS19275 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G9272_RS19285 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G9272_RS19295 ENOG41067SE Tetr family transcriptional regulator G9272_RS19310 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G9272_RS19315 ENOG4108ZT1 Transcriptional regulator G9272_RS19320 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS19330 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G9272_RS19405 ENOG4105C5H ABC transporter G9272_RS19415 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G9272_RS19420 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G9272_RS19430 ENOG4105F8V Hydrolase, tatD family G9272_RS19460 ENOG4105KF0 sporulation and cell division protein, SsgA G9272_RS19465 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) G9272_RS19475 ENOG4108JJB ABC transporter G9272_RS19480 ENOG4105K56 Transcriptional regulator G9272_RS19485 ENOG4108ZHJ Organic hydroperoxide resistance protein G9272_RS19510 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G9272_RS19515 ENOG4105EYF MMPL domain protein G9272_RS19535 ENOG4108BAS reductase G9272_RS19540 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G9272_RS19545 ENOG4105F95 Monooxygenase G9272_RS19565 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS19595 ENOG4108Z9I -acetyltransferase G9272_RS19600 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G9272_RS19605 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G9272_RS19615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G9272_RS19620 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G9272_RS19645 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G9272_RS19655 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G9272_RS19670 ENOG4105KXX peptidase s58 dmpa G9272_RS19675 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G9272_RS19690 ENOG4105DM4 PTS System G9272_RS19700 ENOG410804X Transcriptional regulator G9272_RS19725 ENOG4108Z7F N-acetyltransferase G9272_RS19730 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G9272_RS19755 ENOG4107HP6 Transcriptional regulator G9272_RS19800 ENOG4105ECY inositol monophosphatase G9272_RS19880 ENOG4105VBF alkaline shock protein G9272_RS19900 ENOG4105DFW ABC transporter G9272_RS19905 ENOG4108KPJ rna polymerase sigma factor G9272_RS19920 ENOG4105BZU Histidine kinase G9272_RS19925 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS19935 ENOG4108TGC Acyltransferase G9272_RS19955 ENOG4105K56 Transcriptional regulator G9272_RS20035 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G9272_RS20165 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS20210 ENOG4108762 serine threonine protein kinase G9272_RS20220 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G9272_RS20225 ENOG4108ZRZ Transcriptional regulator (AsnC family) G9272_RS20230 ENOG4105N14 lysine exporter protein LysE YggA G9272_RS20240 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS20265 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G9272_RS20290 ENOG4105H3G oxidoreductase G9272_RS20305 ENOG4105CGU Enoyl-CoA hydratase G9272_RS20340 ENOG4105CC9 acyl-Coa dehydrogenase G9272_RS20345 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G9272_RS20360 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS20365 ENOG4105CC9 acyl-Coa dehydrogenase G9272_RS20385 ENOG41082AN stage II sporulation protein G9272_RS20430 ENOG4105CJ1 ABC, transporter G9272_RS20450 ENOG4108SU4 UPF0309 protein G9272_RS20475 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G9272_RS20490 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS20505 ENOG4107QX3 carboxylase G9272_RS20525 ENOG4107AQZ Membrane G9272_RS20535 ENOG4105CQB FAD linked oxidase domain protein G9272_RS20540 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G9272_RS20545 ENOG4106R7G Glycoside hydrolase family 5 G9272_RS20560 ENOG4105CPC Aldo Keto reductase G9272_RS20600 ENOG4105C7N Xanthine uracil vitamin C permease G9272_RS20610 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G9272_RS20640 ENOG4108N0W Major Facilitator superfamily G9272_RS20650 ENOG4108UIH futalosine nucleosidase G9272_RS20655 ENOG4105E63 Pfam:DUF178 G9272_RS20660 ENOG4105VEQ Cold shock protein G9272_RS20690 ENOG4105CFI type iii restriction protein res subunit G9272_RS20700 ENOG4105EEM helicase G9272_RS20730 ENOG4106KNT transcriptional regulator G9272_RS20735 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G9272_RS20750 ENOG4105EBR Carboxylesterase G9272_RS20755 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS20760 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G9272_RS20810 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G9272_RS20830 ENOG4105C3Q Glycosyl transferase, family 2 G9272_RS20860 ENOG4105CE4 GlcNAc 6-P deacetylase G9272_RS20865 ENOG4105DE4 1-phosphofructokinase G9272_RS20875 ENOG4105BZU Histidine kinase G9272_RS20895 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G9272_RS20965 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G9272_RS20975 ENOG4105C2N RNA methyltransferase TrmH family group 3 G9272_RS20980 ENOG4105C8N cysteinyl-tRNA synthetase G9272_RS20985 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G9272_RS20990 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G9272_RS20995 ENOG4108VJ1 Transcriptional regulator (CarD family G9272_RS21010 ENOG4105BZU Histidine kinase G9272_RS21075 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G9272_RS21100 ENOG4108YZJ Pfam:DUF2596 G9272_RS21105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G9272_RS21165 ENOG41073TP transcriptional regulator G9272_RS21180 ENOG4105HHS UPF0256 protein G9272_RS21190 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G9272_RS21195 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G9272_RS21205 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G9272_RS21235 ENOG4105PKJ carbohydrate binding G9272_RS21240 ENOG4105KHC sulfurtransferase G9272_RS21265 ENOG4107NHD transcriptional regulator G9272_RS21270 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS21275 ENOG4105C0H protease G9272_RS21285 ENOG4105ETX regulatoR G9272_RS21290 ENOG41062D9 Histidine kinase G9272_RS21300 ENOG4105ETX regulatoR G9272_RS21305 ENOG4105BZ1 (ABC) transporter G9272_RS21310 ENOG4105CGH 5'-nucleotidase G9272_RS21315 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G9272_RS21330 ENOG4105CJ1 ABC, transporter G9272_RS21345 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G9272_RS21350 ENOG4105CZV ABC transporter G9272_RS21365 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G9272_RS21395 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G9272_RS21400 ENOG4105CJ3 phosphate transporter G9272_RS21410 ENOG4105VPX protein, conserved in bacteria G9272_RS21430 ENOG4105DNP FAD linked oxidase domain protein G9272_RS21435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G9272_RS21440 ENOG4105E4C Lytic transglycosylase catalytic G9272_RS21465 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G9272_RS21545 ENOG4105CEP NADH dehydrogenase G9272_RS21575 ENOG4105D5U fad dependent oxidoreductase G9272_RS21580 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G9272_RS21590 ENOG4105CPC Aldo Keto reductase G9272_RS21615 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) G9272_RS21620 ENOG4107VIJ nudix hydrolase G9272_RS21630 ENOG4105E98 transcriptional regulator DeoR family G9272_RS21665 ENOG4105C1J atp-dependent rna helicase G9272_RS21700 ENOG4105CQ7 ATP-dependent helicase G9272_RS21715 ENOG4108TAC G9272_RS21720 ENOG4107RDP Dehydrogenase G9272_RS21730 ENOG4105CXB phosphoribosylaminoimidazole synthetase G9272_RS21750 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G9272_RS21755 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G9272_RS21760 ENOG410839H phosphoribosylformylglycinamidine synthase G9272_RS21790 ENOG4105BZU Histidine kinase G9272_RS21805 ENOG4105C8V SAICAR synthetase G9272_RS21825 ENOG4105C12 Phosphoribosylglycinamide synthetase G9272_RS21875 ENOG4105CHR reductase G9272_RS21910 ENOG4105D7A ATP-binding protein G9272_RS21925 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G9272_RS21940 ENOG4108Z6B deaminase G9272_RS21965 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein G9272_RS21970 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS21975 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS21990 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G9272_RS21995 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS22000 ENOG4108YYC ycei family G9272_RS22005 ENOG410905P Pyridoxamine 5-phosphate G9272_RS22015 ENOG4105C57 major facilitator superfamily G9272_RS22020 ENOG4105EDW glycosyl transferase, family 39 G9272_RS22030 ENOG4105BZU Histidine kinase G9272_RS22035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS22040 ENOG4105KAC Antibiotic biosynthesis monooxygenase G9272_RS22100 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS22105 ENOG4105NAF rna polymerase sigma factor G9272_RS22110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G9272_RS22170 ENOG4105C0H protease G9272_RS22185 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G9272_RS22205 ENOG4107T6F Xaa-Pro aminopeptidase G9272_RS22220 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G9272_RS22260 ENOG4105DBE peroxidase G9272_RS22270 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G9272_RS22275 ENOG410667J hydrolase G9272_RS22325 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) G9272_RS22340 ENOG410667J hydrolase G9272_RS22345 ENOG41086D8 Transcriptional regulator G9272_RS22350 ENOG4105E4C Lytic transglycosylase catalytic G9272_RS22355 ENOG4108JJ9 ABC, transporter G9272_RS22360 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G9272_RS22365 ENOG4105C4M (Ubiquinol oxidase) subunit I G9272_RS22370 ENOG4105CIH Imidazole acetol-phosphate transaminase G9272_RS22375 ENOG4107P2S Transcriptional regulator G9272_RS22380 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G9272_RS22395 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G9272_RS22420 ENOG4106048 Cupin 2, conserved barrel domain protein G9272_RS22425 ENOG41082T9 Membrane G9272_RS22430 ENOG4105KJF protein tyrosine phosphatase G9272_RS22435 ENOG4105C28 cystathionine G9272_RS22470 ENOG4105F27 Major Facilitator G9272_RS22500 ENOG4105CDU Replicative dna helicase G9272_RS22510 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G9272_RS22515 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G9272_RS22520 ENOG4107YH6 single-stranded DNA-binding protein G9272_RS22525 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G9272_RS22550 ENOG4105BZ4 penicillin-binding protein G9272_RS22575 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G9272_RS22590 ENOG4105D9P serine threonine protein kinase G9272_RS22605 ENOG4105C3M thioredoxin reductase G9272_RS22610 ENOG4105K63 Thioredoxin G9272_RS22625 ENOG4107QJE Chromosome Partitioning Protein G9272_RS22630 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G9272_RS22640 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G9272_RS22645 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G9272_RS22650 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G9272_RS22660 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G9272_RS22665 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G9272_RS22670 ENOG4108J5G 6-phosphogluconate dehydrogenase G9272_RS22675 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G9272_RS22680 ENOG4105K7N UPF0232 protein G9272_RS22685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9272_RS22690 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9272_RS22705 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G9272_RS22755 ENOG4105ZJT Cell division protein CrgA G9272_RS22765 ENOG4108U4N (sortase) family G9272_RS22780 ENOG4108U4N (sortase) family G9272_RS22785 ENOG4108RN7 integral membrane protein G9272_RS22795 ENOG4105CJN penicillin-binding protein G9272_RS22810 ENOG4105HZM Fha domain containing protein G9272_RS22815 ENOG4105TV9 FHA Domain-Containing protein G9272_RS22845 ENOG4108KC2 acyl-Coa dehydrogenase G9272_RS22850 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9272_RS22855 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G9272_RS22860 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G9272_RS22865 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G9272_RS22870 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G9272_RS22885 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase G9272_RS22895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9272_RS22900 ENOG4108IG5 Transcriptional regulator G9272_RS22920 ENOG4107QSN dihydrolipoamide acetyltransferase G9272_RS22965 ENOG4108VC7 Protein of unknown function (DUF2587) G9272_RS22970 ENOG4107QPV Serine Threonine protein kinase G9272_RS22980 ENOG4105CUV Homoserine Kinase G9272_RS22990 ENOG4105CPP Dehydrogenase, E1 component G9272_RS22995 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G9272_RS23070 ENOG4105DFM M18 family aminopeptidase G9272_RS23075 ENOG4105CSU acyl-Coa dehydrogenase G9272_RS23085 ENOG4105EUB pirin domain protein G9272_RS23105 ENOG4105C9M aspartyl-trna synthetase G9272_RS23165 ENOG4108J20 pectate lyase G9272_RS23175 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G9272_RS23190 ENOG410613R integral membrane protein, YccS YhfK family G9272_RS23195 ENOG4107NA1 Endonuclease Exonuclease phosphatase G9272_RS23205 ENOG4107SQD Transcriptional regulator, GntR family G9272_RS23245 ENOG4108PJD permease G9272_RS23265 ENOG4105C22 threonyL-tRNA synthetase G9272_RS23280 ENOG4105CG3 alpha amylase, catalytic region G9272_RS23300 ENOG4105EBR Carboxylesterase G9272_RS23385 ENOG4108KGH TRANSCRIPTIONal G9272_RS23390 ENOG4105BZU Histidine kinase G9272_RS23410 ENOG4108KPJ rna polymerase sigma factor G9272_RS23540 ENOG4105C1J atp-dependent rna helicase G9272_RS23545 ENOG4105VEQ Cold shock protein G9272_RS23580 ENOG410905P Pyridoxamine 5-phosphate G9272_RS23610 ENOG4105I6B RNA polymerase G9272_RS23630 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS23660 ENOG4105VEQ Cold shock protein G9272_RS23665 ENOG4107T94 Endo-14-beta-xylanase G9272_RS23675 ENOG4108HWW ABC transporter G9272_RS23680 ENOG4105C2J ABC transporter G9272_RS23685 ENOG4105DFW ABC transporter G9272_RS23705 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS23710 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS23715 ENOG4105BZU Histidine kinase G9272_RS23725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G9272_RS23775 ENOG4107U9T Pfam:Ribonuclease_BN G9272_RS23845 ENOG4105CJ1 ABC, transporter G9272_RS23855 ENOG4105BZU Histidine kinase G9272_RS23860 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS23925 ENOG4105DHP deoxycytidine triphosphate deaminase G9272_RS23930 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) G9272_RS23945 ENOG4105DF6 Fe-S oxidoreductase G9272_RS23955 ENOG4105CFG Acts as a chaperone (By similarity) G9272_RS23960 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G9272_RS23965 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G9272_RS23970 ENOG4105KNI merR family transcriptional Regulator G9272_RS24090 ENOG4105DFW ABC transporter G9272_RS24135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G9272_RS24165 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G9272_RS24180 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G9272_RS24195 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G9272_RS24200 ENOG4107RCW fructose-bisphosphate aldolase G9272_RS24215 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G9272_RS24220 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) G9272_RS24240 ENOG4105BZU Histidine kinase G9272_RS24245 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS24250 ENOG4105BZU Histidine kinase G9272_RS24255 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS24275 ENOG4105DIM ABC transporter G9272_RS24280 ENOG4105CIG ABC transporter G9272_RS24295 ENOG4105CPD ethanolamine ammonia-lyase G9272_RS24300 ENOG4107FQ9 ethanolamine ammonia-lyase G9272_RS24310 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G9272_RS24315 ENOG4105CGH 5'-nucleotidase G9272_RS24330 ENOG4105CKK Glycosyl transferase, family 2 G9272_RS24335 ENOG4108WYP Transcriptional regulator G9272_RS24340 ENOG4108JPW Aminotransferase G9272_RS24345 ENOG4108V4B ThiJ pfpI G9272_RS24360 ENOG4105CVA phosphate G9272_RS24370 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G9272_RS24375 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G9272_RS24395 ENOG4105EB3 Histidine kinase G9272_RS24405 ENOG4105CFH Aspartokinase G9272_RS24415 ENOG4105NAF rna polymerase sigma factor G9272_RS24440 ENOG4108PJD permease G9272_RS24455 ENOG4105CVR type I restriction-modification system G9272_RS24485 ENOG4108HMN Caspase domain G9272_RS24505 ENOG4107Z3H Transcriptional regulator, TetR family G9272_RS24510 ENOG4108RYK Nad-dependent epimerase dehydratase G9272_RS24520 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G9272_RS24535 ENOG4105VBF alkaline shock protein G9272_RS24555 ENOG41062D9 Histidine kinase G9272_RS24575 ENOG4105BZ4 penicillin-binding protein G9272_RS24585 ENOG4105EMN RNA polymerase sigma factor G9272_RS24655 ENOG4105BZU Histidine kinase G9272_RS24670 ENOG4105M6F mutator MutT protein G9272_RS24685 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) G9272_RS24695 ENOG4105CVJ phosphoglycerate mutase G9272_RS24700 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G9272_RS24815 ENOG4105BZ4 penicillin-binding protein G9272_RS24850 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G9272_RS24870 ENOG4105P8F nudix hydrolase G9272_RS24880 ENOG4105D74 hydrolase G9272_RS24890 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G9272_RS24895 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G9272_RS24900 ENOG4107B2H carbonic anhydrase G9272_RS24960 ENOG4108I5C dEAD DEAH box helicase G9272_RS24965 ENOG4105WN5 stage II sporulation protein G9272_RS24970 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G9272_RS24975 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for G9272_RS24995 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G9272_RS25000 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G9272_RS25025 ENOG4107T65 Integrase G9272_RS25035 ENOG4107ZVI PhiRv2 prophage protein G9272_RS25050 ENOG4107RHI Cytosine-specific methyltransferase G9272_RS25110 ENOG41062IR nudix hydrolase G9272_RS25145 ENOG4105C4R Atp-dependent dna helicase G9272_RS25210 ENOG4108JQ1 Dehydrogenase G9272_RS25235 ENOG4105C2M dna polymerase I G9272_RS25260 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G9272_RS25265 ENOG4105KDC 50s ribosomal protein l28 G9272_RS25275 ENOG4105NRA 50s ribosomal protein l31 type b G9272_RS25285 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G9272_RS25305 ENOG4105C26 Dehydrogenase G9272_RS25325 ENOG4105CVK Glutamate decarboxylase G9272_RS25330 ENOG4105VCT ion-transport protein YfeO G9272_RS25335 ENOG4107TXC Transcriptional regulator G9272_RS25340 ENOG41082VC UPF0145 protein G9272_RS25355 ENOG4105F0N pyrophosphate phospho-hydrolase G9272_RS25370 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G9272_RS25375 ENOG4108UGV hypoxanthine phosphoribosyltransferase G9272_RS25385 ENOG4105EUJ GTP cyclohydrolase i G9272_RS25395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G9272_RS25415 ENOG4105CRK lysyL-tRNA synthetase G9272_RS25440 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS25455 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS25460 ENOG41082SX arsR family transcriptional regulator G9272_RS25480 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G9272_RS25485 ENOG4108IYU L-aspartate oxidase G9272_RS25495 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G9272_RS25540 ENOG4105DR5 peptidase G9272_RS25545 ENOG4108IG5 Transcriptional regulator G9272_RS25550 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS25555 ENOG4108FKE two-component system sensor kinase G9272_RS25560 ENOG4108PYU two-component system response regulator G9272_RS25565 ENOG41075QH Lipoprotein CseA G9272_RS25570 ENOG4105NAF rna polymerase sigma factor G9272_RS25575 ENOG4105CEN a g-specific adenine glycosylase G9272_RS25585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G9272_RS25600 ENOG4108JWX G9272_RS25605 ENOG4107R33 ppx gppa phosphatase G9272_RS25610 ENOG4105EY0 Xylose isomerase domain protein TIM barrel G9272_RS25615 ENOG4105PF9 Transcriptional regulator G9272_RS25620 ENOG4105C01 Dihydroxy-acid dehydratase G9272_RS25630 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein G9272_RS25645 ENOG4105CHH sulfate transporter G9272_RS25650 ENOG4105CJ1 ABC, transporter G9272_RS25660 ENOG4105II7 pyrroline-5-carboxylate reductase G9272_RS25670 ENOG4105ECQ AraC Family Transcriptional Regulator G9272_RS25675 ENOG4105C31 Tryptophanyl-tRNA synthetase G9272_RS25695 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G9272_RS25710 ENOG4105DGU Histone deacetylase G9272_RS25715 ENOG4108XFF G9272_RS25770 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) G9272_RS25775 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G9272_RS25780 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G9272_RS25785 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G9272_RS25795 ENOG4105D52 delta-aminolevulinic acid dehydratase G9272_RS25820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9272_RS25840 ENOG4105C75 arginyL-tRNA synthetase G9272_RS25845 ENOG4105DK7 lysyl-tRNA synthetase G9272_RS25865 ENOG4105E0Y RtcB Protein G9272_RS25885 ENOG4105KK4 UPF0060 membrane protein G9272_RS25910 ENOG4105KVH Transcriptional regulator G9272_RS25925 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G9272_RS25930 ENOG4108UZX fmn reductase G9272_RS25940 ENOG41062D9 Histidine kinase G9272_RS25965 ENOG4105CSH Transporter G9272_RS26000 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G9272_RS26005 ENOG4108RH7 phosphoglycerate mutase G9272_RS26015 ENOG4107ZT5 Thiol disulfide interchange protein G9272_RS26020 ENOG4107QIV Cytochrome c biogenesis protein G9272_RS26025 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) G9272_RS26030 ENOG4105CRE cytochrome C G9272_RS26070 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G9272_RS26080 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G9272_RS26090 ENOG4105DVY radical SAM domain protein G9272_RS26105 ENOG4108R86 Transcriptional regulator G9272_RS26115 ENOG4105CHR reductase G9272_RS26120 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS26180 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G9272_RS26200 ENOG4107R6F Alpha Beta Hydrolase Fold protein G9272_RS26205 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) G9272_RS26210 ENOG4105VEQ Cold shock protein G9272_RS26215 ENOG4105EV6 Pfam:DUF178 G9272_RS26235 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G9272_RS26255 ENOG4105CND Glycosyl transferase, family 2 G9272_RS26265 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS26275 ENOG4105KNA -acetyltransferase G9272_RS26295 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26300 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G9272_RS26305 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26315 ENOG4107QIZ NADH dehydrogenase G9272_RS26320 ENOG4108IEH NADH dehydrogenase subunit g G9272_RS26325 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G9272_RS26330 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26335 ENOG4105DF2 NADH dehydrogenase subunit j G9272_RS26340 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26345 ENOG4105D65 subunit l G9272_RS26355 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26360 ENOG4105C9U ATP-dependent DNA helicase RecQ G9272_RS26365 ENOG4108IYU L-aspartate oxidase G9272_RS26370 ENOG4108IY8 ABC, transporter G9272_RS26390 ENOG4105FDP GntR family transcriptional regulator G9272_RS26450 ENOG410667J hydrolase G9272_RS26455 ENOG4108FKH Transglycosylase SLT domain G9272_RS26470 ENOG4105CJ1 ABC, transporter G9272_RS26480 ENOG4108WS4 fmn reductase G9272_RS26515 ENOG4105ECR NmrA family G9272_RS26520 ENOG4105KVH Transcriptional regulator G9272_RS26525 ENOG4105DQU oxidoreductase, subunit beta G9272_RS26530 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G9272_RS26550 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G9272_RS26555 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26560 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G9272_RS26565 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G9272_RS26570 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26575 ENOG4107YX3 NADH dehydrogenase subunit j G9272_RS26580 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26590 ENOG4105C8S subunit m G9272_RS26595 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G9272_RS26600 ENOG4105D0M Protease HtpX homolog G9272_RS26605 ENOG410901E Membrane G9272_RS26620 ENOG4105Y3U Transglycosylase-associated protein G9272_RS26625 ENOG4108VPT UPF0234 protein G9272_RS26670 ENOG4105WDJ 50S ribosomal protein L33 G9272_RS26675 ENOG410900P UPF0336 protein G9272_RS26695 ENOG4107R4N Cell wall formation (By similarity) G9272_RS26700 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G9272_RS26720 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G9272_RS26725 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G9272_RS26730 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G9272_RS26740 ENOG4105QCJ Lipoprotein G9272_RS26745 ENOG4108VZM 50s ribosomal protein L10 G9272_RS26750 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G9272_RS26755 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9272_RS26760 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9272_RS26895 ENOG4105CKK Glycosyl transferase, family 2 G9272_RS26900 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G9272_RS26905 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G9272_RS26910 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G9272_RS26915 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G9272_RS26930 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G9272_RS26935 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G9272_RS26940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G9272_RS26945 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G9272_RS26950 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G9272_RS26955 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G9272_RS26960 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G9272_RS26965 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G9272_RS26970 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G9272_RS26975 ENOG41082SA 50s ribosomal protein l29 G9272_RS26980 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G9272_RS26985 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G9272_RS26990 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G9272_RS26995 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G9272_RS27000 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G9272_RS27005 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G9272_RS27010 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G9272_RS27015 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G9272_RS27020 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G9272_RS27025 ENOG410849U 50S ribosomal protein L30 G9272_RS27030 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G9272_RS27040 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G9272_RS27050 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G9272_RS27055 ENOG41067V7 50S ribosomal protein L36 G9272_RS27060 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G9272_RS27065 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G9272_RS27070 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9272_RS27075 ENOG4108ZT0 50S ribosomal protein l17 G9272_RS27080 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G9272_RS27090 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G9272_RS27095 ENOG4108UJD 30S ribosomal protein S9 G9272_RS27100 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G9272_RS27110 ENOG4105CS9 pantothenic acid kinase G9272_RS27115 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G9272_RS27145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G9272_RS27150 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G9272_RS27155 ENOG4108097 ATP-binding protein G9272_RS27180 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G9272_RS27205 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G9272_RS27210 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS27220 ENOG4107TB5 TRANSCRIPTIONal G9272_RS27240 ENOG4105CHP RNA polymerase G9272_RS27265 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G9272_RS27270 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G9272_RS27280 ENOG4105EMU Dehydrogenase G9272_RS27290 ENOG4105DND Transcriptional regulator G9272_RS27295 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G9272_RS27305 ENOG4108MMM RNA Polymerase G9272_RS27315 ENOG4107QVP Dehydrogenase G9272_RS27320 ENOG4107QQG Dehydrogenase G9272_RS27325 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G9272_RS27340 ENOG4105D9P serine threonine protein kinase G9272_RS27345 ENOG4105D9P serine threonine protein kinase G9272_RS27350 ENOG4108UGD Serine Threonine protein kinase G9272_RS27355 ENOG4107TPY serine threonine protein kinase G9272_RS27365 ENOG4105C26 Dehydrogenase G9272_RS27390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G9272_RS27440 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS27470 ENOG4105DR5 peptidase G9272_RS27495 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G9272_RS27500 ENOG4105RD5 G9272_RS27505 ENOG4105DEG Vwa containing coxe family protein G9272_RS27515 ENOG4105CMV Succinyl-CoA synthetase subunit beta G9272_RS27545 ENOG4105DC1 bifunctional purine biosynthesis protein purh G9272_RS27555 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS27575 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G9272_RS27590 ENOG4105C57 major facilitator superfamily G9272_RS27615 ENOG4108IJ7 Glycine betaine G9272_RS27620 ENOG4108HQS Glycine betaine G9272_RS27635 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS27640 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS27645 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9272_RS27650 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS27660 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G9272_RS27665 ENOG410680H amp-dependent synthetase and ligase G9272_RS27670 ENOG4108ES0 acetoacetyl-CoA synthetase G9272_RS27680 ENOG4108ZFD Antibiotic biosynthesis monooxygenase G9272_RS27700 ENOG4106032 Glutathionylspermidine synthase G9272_RS27705 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G9272_RS27710 ENOG4105C31 Tryptophanyl-tRNA synthetase G9272_RS27740 ENOG4107H3J ribonuclease G9272_RS27755 ENOG4107RN3 metallophosphoesterase G9272_RS27770 ENOG4105BZU Histidine kinase G9272_RS27775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS27780 ENOG4105EYF MMPL domain protein G9272_RS27825 ENOG4108J01 L-aspartate oxidase G9272_RS27845 ENOG4105E2D ec 3.2.1.52 G9272_RS27870 ENOG4108MMM RNA Polymerase G9272_RS27905 ENOG4105CKK Glycosyl transferase, family 2 G9272_RS27925 ENOG4105K64 Glycosyl transferase, family 2 G9272_RS27945 ENOG4105K64 Glycosyl transferase, family 2 G9272_RS27955 ENOG4105F0R Cytidylyltransferase G9272_RS27960 ENOG4105D2T synthase G9272_RS27970 ENOG4107RM1 amidohydrolase G9272_RS27975 ENOG4105DIH basic membrane G9272_RS27980 ENOG4105DIH basic membrane G9272_RS27985 ENOG4108JQ9 ABC transporter G9272_RS28020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G9272_RS28025 ENOG4105D94 Major Facilitator Superfamily G9272_RS28030 ENOG4107RSM transcriptional regulator G9272_RS28040 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G9272_RS28065 ENOG41065SU Two-component system sensor kinase G9272_RS28070 ENOG4108KXV response regulator G9272_RS28075 ENOG4105NAF rna polymerase sigma factor G9272_RS28090 ENOG4105C26 Dehydrogenase G9272_RS28095 ENOG4105C26 Dehydrogenase G9272_RS28100 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G9272_RS28115 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G9272_RS28145 ENOG4108JIK carboxylase G9272_RS28155 ENOG4107WR6 Maf-like protein G9272_RS28165 ENOG4105D8K carboxyl transferase G9272_RS28175 ENOG4108QER Adenylate cyclase G9272_RS28185 ENOG4105E39 Enoyl-CoA hydratase G9272_RS28190 ENOG4105KDM Diguanylate cyclase with gaf sensor G9272_RS28195 ENOG4105C84 Histidine ammonia-lyase G9272_RS28225 ENOG4105C19 ABC transporter G9272_RS28240 ENOG4105DQ4 alcohol dehydrogenase G9272_RS28245 ENOG4105TVJ transport system, permease G9272_RS28250 ENOG4105DQ5 transport system permease protein G9272_RS28285 ENOG4105C02 permease G9272_RS28290 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G9272_RS28315 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G9272_RS28320 ENOG4105C7B Threonine dehydratase G9272_RS28335 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G9272_RS28345 ENOG4105T1M mycothiol conjugate amidase mca G9272_RS28355 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G9272_RS28360 ENOG4105C7Z Conserved Protein G9272_RS28395 ENOG4105C57 major facilitator superfamily G9272_RS28405 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G9272_RS28435 ENOG4105CHM Aminotransferase G9272_RS28450 ENOG4105C7W Xanthine dehydrogenase G9272_RS28480 ENOG4108FUF Transcriptional regulator, IclR family G9272_RS28485 ENOG4105KME endoribonuclease L-psp G9272_RS28490 ENOG4105C6Z Gluconate G9272_RS28540 ENOG4105D7V transposase G9272_RS28585 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS28615 ENOG4105NAE bifunctional deaminase-reductase domain protein G9272_RS28620 ENOG4105F2W methyltransferase G9272_RS28625 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G9272_RS28630 ENOG4108IAB Phoh family G9272_RS28635 ENOG4106770 Is able to cleave peptidoglycan (By similarity) G9272_RS28670 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G9272_RS28690 ENOG4105BZ4 penicillin-binding protein G9272_RS28700 ENOG4105EVI UPF0374 protein G9272_RS28705 ENOG4105C9Q fumarate hydratase class II G9272_RS28710 ENOG4105JVQ RNA Polymerase G9272_RS28740 ENOG4107GFK fumarate G9272_RS28750 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G9272_RS28765 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G9272_RS28770 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G9272_RS28775 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G9272_RS28780 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G9272_RS28795 ENOG4105C3G gtp-binding protein G9272_RS28865 ENOG4105DZR Type I site-specific deoxyribonuclease G9272_RS28900 ENOG4108M15 ABC transporter G9272_RS28910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G9272_RS28915 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS28920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9272_RS28925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G9272_RS28945 ENOG4105CHR reductase G9272_RS28950 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9272_RS28975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G9272_RS28990 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS29060 ENOG4105E33 succinate dehydrogenase G9272_RS29065 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G9272_RS29085 ENOG4105CI3 gtp-binding protein typa G9272_RS29090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS29095 ENOG4108J59 Extracellular solute-binding protein, family 5 G9272_RS29105 ENOG4105C3U ABC transporter G9272_RS29110 ENOG4108JQ7 (ABC) transporter G9272_RS29115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G9272_RS29155 ENOG4105BZ1 (ABC) transporter G9272_RS29160 ENOG4105CJA serine threonine protein kinase G9272_RS29165 ENOG4108JQ7 (ABC) transporter G9272_RS29185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS29195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G9272_RS29200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS29205 ENOG4105C3U ABC transporter G9272_RS29210 ENOG4108JQ7 (ABC) transporter G9272_RS29265 ENOG4108M15 ABC transporter G9272_RS29275 ENOG4105BZU Histidine kinase G9272_RS29280 ENOG4108S01 response regulator G9272_RS29295 ENOG4108Z4U Ferredoxin G9272_RS29315 ENOG4107R4C succinyl-diaminopimelate desuccinylase G9272_RS29320 ENOG4108URH decarboxylase G9272_RS29325 ENOG4105EEI dihydropteroate synthase G9272_RS29335 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G9272_RS29340 ENOG4108UKI Enoyl-CoA hydratase G9272_RS29355 ENOG4105DU6 RNA polymerase G9272_RS29365 ENOG4105C0H protease G9272_RS29370 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G9272_RS29405 ENOG4105D7N magnesium and cobalt transport protein CorA G9272_RS29415 ENOG4105DXB Major Facilitator superfamily G9272_RS29430 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G9272_RS29450 ENOG4105C1J atp-dependent rna helicase G9272_RS29490 ENOG4105DEF Extracellular solute-binding protein, family 5 G9272_RS29495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS29535 ENOG4106JDR secreted G9272_RS29560 ENOG4105C4R Atp-dependent dna helicase G9272_RS29565 ENOG4107QSE Dipeptidase G9272_RS29590 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G9272_RS29655 ENOG41063PX domain protein G9272_RS29665 ENOG4105DJZ UPF0182 protein G9272_RS29695 ENOG4107TK4 histidinol-phosphate phosphatase G9272_RS29715 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G9272_RS29725 ENOG4108RAV Conserved protein G9272_RS29735 ENOG4105EMN RNA polymerase sigma factor G9272_RS29740 ENOG4105WMN AntiSigma factor G9272_RS29745 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G9272_RS29760 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G9272_RS29770 ENOG41068W2 Cytochrome p-450 G9272_RS29785 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9272_RS29790 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9272_RS29810 ENOG4105FDP GntR family transcriptional regulator G9272_RS29830 ENOG4105D17 glycoside hydrolase, family 3 domain protein G9272_RS29835 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G9272_RS29850 ENOG4105CBD Diacylglycerol kinase G9272_RS29880 ENOG4105K6H D-cysteine desulfhydrase G9272_RS29885 ENOG4105ESN nucleotide-binding protein G9272_RS29925 ENOG4108VEQ Superoxide dismutase G9272_RS29940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G9272_RS29945 ENOG4105CDA abc transporter atp-binding protein G9272_RS29950 ENOG4105E5Q amino acid AbC transporter G9272_RS29960 ENOG4105C6K Malic enzyme G9272_RS29965 ENOG4105CB2 alcohol dehydrogenase G9272_RS30040 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G9272_RS30045 ENOG4105EB3 Histidine kinase G9272_RS30050 ENOG4108PYU two-component system response regulator G9272_RS30075 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G9272_RS30115 ENOG4105K4H Nlp p60 protein G9272_RS30125 ENOG41060BG Tetr family transcriptional regulator G9272_RS30155 ENOG4105CJN penicillin-binding protein G9272_RS30170 ENOG4108FKE two-component system sensor kinase G9272_RS30190 ENOG4105DQE DNA ligase G9272_RS30195 ENOG4105FDF Could be involved in DNA repair (By similarity) G9272_RS30205 ENOG4105DJ2 Major Facilitator Superfamily G9272_RS30220 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS30400 ENOG4105C75 arginyL-tRNA synthetase G9272_RS30405 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G9272_RS30410 ENOG4105D6E homoserine dehydrogenase G9272_RS30415 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G9272_RS30420 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G9272_RS30435 ENOG4108RCF TRANSCRIPTIONal G9272_RS30440 ENOG4105VFB Binds the 23S rRNA (By similarity) G9272_RS30445 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G9272_RS30450 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G9272_RS30460 ENOG4107ZF2 Phosphatase G9272_RS30465 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G9272_RS30470 ENOG4105ESV Glycosyl transferase, family 4 G9272_RS30475 ENOG4105Z3P ATP synthase G9272_RS30485 ENOG4105ZA1 atp synthase G9272_RS30490 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) G9272_RS30495 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G9272_RS30500 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G9272_RS30505 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G9272_RS30510 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G9272_RS30515 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G9272_RS30530 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS30535 ENOG4105BZU Histidine kinase G9272_RS30560 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) G9272_RS30595 ENOG4105CJ1 ABC, transporter G9272_RS30610 ENOG4108ZVT methylmalonyl-coA epimerase G9272_RS30615 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS30635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS30695 ENOG4105WX6 Membrane G9272_RS30735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G9272_RS30740 ENOG4105C6K Malic enzyme G9272_RS30745 ENOG4105CTQ phosphohexokinase G9272_RS30755 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G9272_RS30765 ENOG4108MRH transcriptional regulatory protein G9272_RS30775 ENOG4107QJT sodium dicarboxylate symporter G9272_RS30780 ENOG4108FN7 Aldo keto reductase G9272_RS30800 ENOG4105C3M thioredoxin reductase G9272_RS30810 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G9272_RS30815 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G9272_RS30825 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G9272_RS30830 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin G9272_RS30835 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G9272_RS30850 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G9272_RS30875 ENOG4105BZ1 (ABC) transporter G9272_RS30880 ENOG4105BZ1 (ABC) transporter G9272_RS30885 ENOG4105BZ1 (ABC) transporter G9272_RS30890 ENOG4105BZ1 (ABC) transporter G9272_RS30900 ENOG41061MV Arylsulfatase G9272_RS30915 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G9272_RS30965 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) G9272_RS30975 ENOG4105EJQ L-serine dehydratase G9272_RS30980 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G9272_RS30985 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G9272_RS30990 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G9272_RS31010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS31030 ENOG4108JQ7 (ABC) transporter G9272_RS31035 ENOG4105EN6 Membrane G9272_RS31040 ENOG4108SEA Esterase G9272_RS31075 ENOG4105E6M Sulphatase-modifying factor protein G9272_RS31085 ENOG4105E3B Multicopper oxidase G9272_RS31090 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G9272_RS31095 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G9272_RS31110 ENOG4108URH decarboxylase G9272_RS31125 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G9272_RS31130 ENOG4105BZU Histidine kinase G9272_RS31135 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G9272_RS31140 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G9272_RS31150 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G9272_RS31160 ENOG4105EYF MMPL domain protein G9272_RS31165 ENOG4105D9U N-acetyltransferase G9272_RS31180 ENOG4107SM8 Adenylate Guanylate cyclase G9272_RS31195 ENOG4105CPC Aldo Keto reductase G9272_RS31205 ENOG4105BZU Histidine kinase G9272_RS31215 ENOG4108ZP8 Acetolactate synthase small subunit G9272_RS31220 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G9272_RS31225 ENOG4108JQ1 Dehydrogenase G9272_RS31230 ENOG4105C57 major facilitator superfamily G9272_RS31240 ENOG4107YHD transcriptional regulator G9272_RS31250 ENOG4105C26 Dehydrogenase G9272_RS31260 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G9272_RS31270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G9272_RS31275 ENOG4105CM2 brancheD-chain amino acid aminotransferase G9272_RS31285 ENOG4105CQM Urea amidohydrolase subunit alpha G9272_RS31290 ENOG4105DWY Agmatine deiminase G9272_RS31300 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G9272_RS31310 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G9272_RS31355 ENOG4105D8K carboxyl transferase G9272_RS31375 ENOG4105GWZ Roadblock lc7 family protein G9272_RS31395 ENOG4105GWZ Roadblock lc7 family protein G9272_RS31410 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS31415 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G9272_RS31460 ENOG41069M3 Transcriptional regulator G9272_RS31465 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G9272_RS31470 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G9272_RS31480 ENOG4105K70 DNA-binding protein G9272_RS31500 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G9272_RS31505 ENOG4105CPF Cell wall formation (By similarity) G9272_RS31525 ENOG4105DWF phosphomethylpyrimidine kinase G9272_RS31540 ENOG4105VB9 50S ribosomal protein l28 G9272_RS31545 ENOG4105DP4 dak2 domain fusion protein ylov G9272_RS31565 ENOG4106H78 methyltransferase G9272_RS31570 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G9272_RS31585 ENOG41084BZ 50S ribosomal protein L32 G9272_RS31590 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G9272_RS31595 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G9272_RS31600 ENOG4105KVH Transcriptional regulator G9272_RS31605 ENOG4105CS1 NAD(P)H quinone oxidoreductase G9272_RS31610 ENOG4105K4I Scp-like extracellular G9272_RS31615 ENOG4108375 Acylphosphatase (EC 3.6.1.7) G9272_RS31665 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G9272_RS31680 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) G9272_RS31690 ENOG4105K5M 30s ribosomal protein S16 G9272_RS31695 ENOG41082KU UPF0109 protein G9272_RS31700 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G9272_RS31705 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G9272_RS31710 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G9272_RS31715 ENOG4107QYR Signal peptidase i G9272_RS31720 ENOG4107QYR Signal peptidase i G9272_RS31735 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G9272_RS31745 ENOG41080R2 UPF0102 protein G9272_RS31755 ENOG4108SVB resolvase G9272_RS32190 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS32205 ENOG4105CE9 30S ribosomal protein S2 G9272_RS32210 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G9272_RS32215 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G9272_RS32220 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G9272_RS32225 ENOG4105KNE Phosphatidate cytidylyltransferase G9272_RS32235 ENOG4105RV9 Transcriptional regulator G9272_RS32240 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G9272_RS32250 ENOG4105ECW sulfate abc transporter G9272_RS32255 ENOG4108UCS ABC, transporter G9272_RS32280 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G9272_RS32285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G9272_RS32295 ENOG4105C26 Dehydrogenase G9272_RS32310 ENOG4105E1F short-chain dehydrogenase reductase G9272_RS32330 ENOG4105JVQ RNA Polymerase G9272_RS32370 ENOG4105KVH Transcriptional regulator G9272_RS32385 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G9272_RS32410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9272_RS32415 ENOG4105F38 ABC transporter, permease G9272_RS32420 ENOG4105D38 putrescine abc transporter G9272_RS32425 ENOG4105CJP fad dependent oxidoreductase G9272_RS32435 ENOG4105G9B Transcriptional regulator G9272_RS32460 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G9272_RS32475 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G9272_RS32545 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G9272_RS32550 ENOG4105DZP Membrane-associated zinc metalloprotease G9272_RS32555 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G9272_RS32570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G9272_RS32605 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase G9272_RS32620 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) G9272_RS32635 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G9272_RS32645 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G9272_RS32650 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G9272_RS32760 ENOG4105EC2 ftsk spoIIIe G9272_RS32775 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G9272_RS32780 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G9272_RS32785 ENOG4105C1V Peptidase, M16 G9272_RS32790 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G9272_RS32815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9272_RS32820 ENOG4105CN5 Metallo-Beta-Lactamase G9272_RS32855 ENOG4105BZU Histidine kinase G9272_RS32860 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G9272_RS32875 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G9272_RS32885 ENOG4105CEV competence damage-inducible protein G9272_RS32890 ENOG4105WBV Transcriptional regulator G9272_RS32895 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G9272_RS32900 ENOG4105CHR reductase G9272_RS32905 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G9272_RS32910 ENOG4107QRT dEAD DEAH box helicase G9272_RS32915 ENOG4106AXJ AraC family transcriptional regulator G9272_RS32940 ENOG4105DSF transport protein G9272_RS32950 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G9272_RS32965 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9272_RS32970 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G9272_RS32980 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G9272_RS32990 ENOG4105DRP amino acid AbC transporter G9272_RS32995 ENOG4108Q1T ABC transporter G9272_RS33000 ENOG4107UBR Extracellular solute-binding protein family 3 G9272_RS33005 ENOG4105CDA abc transporter atp-binding protein G9272_RS33010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS33050 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS33055 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G9272_RS33075 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G9272_RS33085 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G9272_RS33090 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G9272_RS33100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G9272_RS33135 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G9272_RS33140 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G9272_RS33145 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G9272_RS33160 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G9272_RS33180 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G9272_RS33195 ENOG4105C9U ATP-dependent DNA helicase RecQ G9272_RS33220 ENOG4105C6F GntR Family Transcriptional Regulator G9272_RS33225 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS33230 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap G9272_RS33240 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9272_RS33255 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS33265 ENOG4107QN1 sodium solute G9272_RS33270 ENOG4108V9W transcriptional regulatory protein G9272_RS33280 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9272_RS33290 ENOG4108V9W transcriptional regulatory protein G9272_RS33305 ENOG4105BZN citrate synthase G9272_RS33325 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G9272_RS33345 ENOG4105DRR Transcriptional regulator, GntR family G9272_RS33350 ENOG410849S phosphocarrier protein (HPr) G9272_RS33355 ENOG4105CD5 CoA-binding domain protein G9272_RS33370 ENOG4107W53 thymidine kinase G9272_RS33405 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G9272_RS33420 ENOG4105F44 Two component transcriptional regulator, winged helix family G9272_RS33425 ENOG4106F60 Histidine kinase G9272_RS33450 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G9272_RS33490 ENOG4107VEG TrkA-N domain protein G9272_RS33495 ENOG4105C0X amino acid G9272_RS33500 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G9272_RS33590 ENOG4105D9P serine threonine protein kinase G9272_RS33675 ENOG4105C2C drug resistance transporter, Bcr CflA G9272_RS33695 ENOG4105C57 major facilitator superfamily G9272_RS33705 ENOG4108YYC ycei family G9272_RS33750 ENOG4107S1Q Phosphatase G9272_RS33770 ENOG4105CEU Arginine dihydrolase G9272_RS33775 ENOG4105DBV ornithine carbamoyltransferase G9272_RS33785 ENOG4105CGU Enoyl-CoA hydratase G9272_RS33835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G9272_RS33840 ENOG4105F4R Transcriptional regulator mode G9272_RS33865 ENOG4108HMN Caspase domain G9272_RS33935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G9272_RS33945 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G9272_RS33960 ENOG4107QM5 aconitate hydratase G9272_RS33965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS33970 ENOG4105BZU Histidine kinase G9272_RS33985 ENOG4105I82 acetyl xylan esterase G9272_RS33995 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G9272_RS34000 ENOG4105E0S extracellular solute-binding protein family 1 G9272_RS34040 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS34050 ENOG4105E2R ROK family G9272_RS34055 ENOG4105DFW ABC transporter G9272_RS34060 ENOG4105C2J ABC transporter G9272_RS34065 ENOG4108HWW ABC transporter G9272_RS34070 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G9272_RS34075 ENOG4105CUB amino acid G9272_RS34090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9272_RS34095 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS34100 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS34120 ENOG4105EG2 ABC transporter, permease G9272_RS34125 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G9272_RS34140 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G9272_RS34155 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase G9272_RS34170 ENOG4107JTW chlorite dismutase G9272_RS34190 ENOG4105E18 UPF0276 protein G9272_RS34200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G9272_RS34235 ENOG4107B2H carbonic anhydrase G9272_RS34260 ENOG4105DFU Cell wall formation (By similarity) G9272_RS34265 ENOG4105E0X reductase G9272_RS34275 ENOG4105BZU Histidine kinase G9272_RS34280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS34285 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G9272_RS34295 ENOG4105CJ2 (LipO)protein G9272_RS34300 ENOG4105EDW glycosyl transferase, family 39 G9272_RS34315 ENOG4108IJ8 ABC transporter G9272_RS34320 ENOG4105E90 ABC transporter G9272_RS34325 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component G9272_RS34345 ENOG4105GWZ Roadblock lc7 family protein G9272_RS34360 ENOG4105C84 Histidine ammonia-lyase G9272_RS34390 ENOG4105DHQ Histidine kinase G9272_RS34430 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G9272_RS34435 ENOG4108IND Tetr family transcriptional regulator G9272_RS34445 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein G9272_RS34450 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G9272_RS34455 ENOG4105DUM transcriptional regulator, lysR family G9272_RS34495 ENOG4105ZSU inhibitor G9272_RS34565 ENOG4108KXV response regulator G9272_RS34570 ENOG41065SU Two-component system sensor kinase G9272_RS34600 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G9272_RS34615 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9272_RS34650 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G9272_RS34665 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G9272_RS34675 ENOG4107RR1 TRANSCRIPTIONal G9272_RS34680 ENOG4105CSU acyl-Coa dehydrogenase G9272_RS34695 ENOG4105E7U AraC family transcriptional regulator G9272_RS34720 ENOG4105CR4 methylisocitrate lyase G9272_RS34735 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS34740 ENOG4105DSG hydrolase family 43 G9272_RS34750 ENOG4105D56 permease protein G9272_RS34765 ENOG4108JQ1 Dehydrogenase G9272_RS34775 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G9272_RS34780 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9272_RS34800 ENOG4105EBR Carboxylesterase G9272_RS34805 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS34810 ENOG4108J5H Homocysteine s-methyltransferase G9272_RS34835 ENOG4107TDE lipolytic protein G-D-S-L family G9272_RS34865 ENOG4105EQK -acetyltransferase G9272_RS34890 ENOG4105CJ1 ABC, transporter G9272_RS34900 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G9272_RS34920 ENOG4105QE3 oxidoreductase G9272_RS34930 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G9272_RS34935 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G9272_RS34945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G9272_RS34965 ENOG4105C7K acetolactate synthase G9272_RS35010 ENOG4105DRR Transcriptional regulator, GntR family G9272_RS35035 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G9272_RS35040 ENOG4105C7N Xanthine uracil vitamin C permease G9272_RS35060 ENOG4108ZJ4 polysaccharide deacetylase G9272_RS35065 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) G9272_RS35070 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) G9272_RS35090 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS35095 ENOG4105BZU Histidine kinase G9272_RS35100 ENOG4105EYF MMPL domain protein G9272_RS35120 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS35145 ENOG4107258 Transcriptional regulator G9272_RS35160 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap G9272_RS35180 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS35190 ENOG41060W2 glyoxylate carboligase G9272_RS35205 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G9272_RS35210 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G9272_RS35230 ENOG4105VT2 5-hydroxyisourate hydrolase G9272_RS35240 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G9272_RS35270 ENOG4105KVH Transcriptional regulator G9272_RS35285 ENOG4108ZM9 phosphoglycerate mutase G9272_RS35290 ENOG4105CHM Aminotransferase G9272_RS35310 ENOG4105DUU IucA IucC family protein G9272_RS35320 ENOG4105CPN adenine deaminase G9272_RS35340 ENOG4105E0A ABC, transporter G9272_RS35345 ENOG4105TVJ transport system, permease G9272_RS35350 ENOG4105DQ5 transport system permease protein G9272_RS35360 ENOG4105WQT MbtH domain protein G9272_RS35365 ENOG4108HUF Transporter G9272_RS35370 ENOG4105BZ1 (ABC) transporter G9272_RS35375 ENOG4105BZ1 (ABC) transporter G9272_RS35385 ENOG4105E0A ABC, transporter G9272_RS35390 ENOG4105EHG Permease protein G9272_RS35410 ENOG4107R9S Malate synthase G9272_RS35425 ENOG4107HP6 Transcriptional regulator G9272_RS35440 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G9272_RS35470 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS35480 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G9272_RS35495 ENOG4105DKQ ROK family G9272_RS35505 ENOG4105C0D helicase G9272_RS35525 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G9272_RS35530 ENOG4105E8R UPF0173 metal-dependent hydrolase G9272_RS35535 ENOG4105CGK Exodeoxyribonuclease III G9272_RS35545 ENOG4105CDA abc transporter atp-binding protein G9272_RS35550 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) G9272_RS35560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G9272_RS35590 ENOG4105C8Y Acetylornithine aminotransferase G9272_RS35605 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) G9272_RS35615 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G9272_RS35630 ENOG4105ECY inositol monophosphatase G9272_RS35640 ENOG4108UVJ appr-1-p processing domain protein G9272_RS35680 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G9272_RS35720 ENOG4105FBN Acid phosphatase G9272_RS35735 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G9272_RS35745 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G9272_RS35755 ENOG4105BZW Glycerate kinase G9272_RS35765 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme G9272_RS35770 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS35780 ENOG4105CI0 Citrate lyase G9272_RS35800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9272_RS35820 ENOG4106JDR secreted G9272_RS35875 ENOG4105F95 Monooxygenase G9272_RS35880 ENOG4108ME1 Peptidase M55 D-aminopeptidase G9272_RS35885 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G9272_RS35890 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G9272_RS35895 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G9272_RS35905 ENOG4105D9U N-acetyltransferase G9272_RS35935 ENOG4105DQE DNA ligase G9272_RS35945 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G9272_RS35970 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G9272_RS35980 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) G9272_RS35995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS36005 ENOG4105GCF PGAM G9272_RS36010 ENOG4105C5H ABC transporter G9272_RS36120 ENOG410842T Pterin carbinolamine dehydratase G9272_RS36125 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G9272_RS36140 ENOG4105D29 Helix-turn-helix type 11 domain protein G9272_RS36145 ENOG4105CX8 fg-gap repeat protein G9272_RS36155 ENOG4105CYP glycoside hydrolase, family G9272_RS36160 ENOG41065HY 1,4-beta-cellobiosidase G9272_RS36165 ENOG41065HY 1,4-beta-cellobiosidase G9272_RS36175 ENOG4105EMU Dehydrogenase G9272_RS36180 ENOG4105CV8 reductase G9272_RS36200 ENOG4105DUM transcriptional regulator, lysR family G9272_RS36205 ENOG4105DHU Bile acid G9272_RS36210 ENOG4105CPQ Dehydrogenase G9272_RS36215 ENOG4108VHT MarR family transcriptional regulator G9272_RS36220 ENOG4105D3W isochorismatase G9272_RS36225 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G9272_RS36240 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G9272_RS36245 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G9272_RS36260 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G9272_RS36270 ENOG4105E2R ROK family G9272_RS36275 ENOG4105C2J ABC transporter G9272_RS36280 ENOG4105CNN ABC, transporter G9272_RS36285 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9272_RS36350 ENOG4105FCD Major Facilitator G9272_RS36370 ENOG4105CMV Succinyl-CoA synthetase subunit beta G9272_RS36380 ENOG4105C26 Dehydrogenase G9272_RS36425 ENOG4105CT3 Monooxygenase G9272_RS36435 ENOG4105CTU Proline racemase G9272_RS36440 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G9272_RS36455 ENOG4105MWK D-amino acid dehydrogenase, small subunit G9272_RS36470 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G9272_RS36475 ENOG4105EGE secreted protein G9272_RS36490 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G9272_RS36500 ENOG4108RZ2 Glycoside hydrolase family 16 G9272_RS36530 ENOG4107RRN ABC transporter substrate-binding protein G9272_RS36535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS36570 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G9272_RS36590 ENOG4107QJN gtp cyclohydrolase ii G9272_RS36625 ENOG410905P Pyridoxamine 5-phosphate G9272_RS36630 ENOG4108MP6 LysR family Transcriptional regulator G9272_RS36650 ENOG4105CSH Transporter G9272_RS36660 ENOG4107S9B Shikimate dehydrogenase G9272_RS36675 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G9272_RS36680 ENOG4108J5G 6-phosphogluconate dehydrogenase G9272_RS36685 ENOG4107QP8 phosphohexose isomerase G9272_RS36700 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G9272_RS36705 ENOG4105CV1 Transketolase (EC 2.2.1.1) G9272_RS36785 ENOG4105CHR reductase G9272_RS36810 ENOG41088CQ domain protein G9272_RS36815 ENOG4105CNT hydrolase family 2 G9272_RS36825 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G9272_RS36835 ENOG4107UEK pfkb domain protein G9272_RS36845 ENOG4105F8D glycoside hydrolase family 4 G9272_RS36860 ENOG4106UDK Cellulose-binding, family II G9272_RS36910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9272_RS36915 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G9272_RS36940 ENOG4105CPC Aldo Keto reductase G9272_RS36975 ENOG4107S5I aldo keto reductase G9272_RS36990 ENOG4105F27 Major Facilitator G9272_RS37000 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G9272_RS37005 ENOG4108RZE Tetr family transcriptional regulator G9272_RS37020 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G9272_RS37030 ENOG4105XDV G9272_RS37050 ENOG4106BQ7 Glycosyl Transferase G9272_RS37070 ENOG4108KEZ Dehydrogenase G9272_RS37085 ENOG4105C26 Dehydrogenase G9272_RS37130 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS37145 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS37160 ENOG4106YT9 Enoyl-CoA hydratase G9272_RS37165 ENOG410846T CoA-transferase family III G9272_RS37170 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS37180 ENOG4105D2B acyl-CoA dehydrogenase G9272_RS37185 ENOG4105FDP GntR family transcriptional regulator G9272_RS37200 ENOG4105CC9 acyl-Coa dehydrogenase G9272_RS37210 ENOG41076PI Short-chain dehydrogenase reductase Sdr G9272_RS37225 ENOG41076PI Short-chain dehydrogenase reductase Sdr G9272_RS37235 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G9272_RS37250 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G9272_RS37255 ENOG4105IKQ hydratase G9272_RS37265 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G9272_RS37280 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS37290 ENOG4105CPQ Dehydrogenase G9272_RS37295 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS37300 ENOG4108IG5 Transcriptional regulator G9272_RS37305 ENOG4105CPP Dehydrogenase, E1 component G9272_RS37325 ENOG4107S2E monooxygenase G9272_RS37330 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G9272_RS37355 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G9272_RS37390 ENOG4108IAJ Nad-dependent epimerase dehydratase G9272_RS37400 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G9272_RS37450 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G9272_RS37455 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G9272_RS37460 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G9272_RS37485 ENOG41067TZ transcriptional regulator, MarR family G9272_RS37505 ENOG4105DQE DNA ligase G9272_RS37525 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS37535 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G9272_RS37585 ENOG4106V2I dimethylaminohydrolase G9272_RS37590 ENOG4105C5H ABC transporter G9272_RS37610 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G9272_RS37620 ENOG4105EG6 Saccharopine dehydrogenase G9272_RS37625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS37630 ENOG4105CHU acetyl-coa acetyltransferase G9272_RS37635 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G9272_RS37655 ENOG4108U3T pfkb domain protein G9272_RS37675 ENOG4108DN8 FAD dependent oxidoreductase G9272_RS37680 ENOG4105C5H ABC transporter G9272_RS37685 ENOG4105BZM domain protein G9272_RS37710 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G9272_RS37730 ENOG4108MDK Dehydrogenase G9272_RS37750 ENOG4105EY8 ABC transporter G9272_RS37755 ENOG4105FBD synthase G9272_RS37765 ENOG4107S11 squalene-associated FAD-dependent desaturase G9272_RS37775 ENOG4105EWU Squalene--hopene cyclase G9272_RS37790 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G9272_RS37830 ENOG4105EKC G9272_RS37840 ENOG4105CX8 fg-gap repeat protein G9272_RS37850 ENOG41090WU lipolytic protein G-D-S-L family G9272_RS37905 ENOG4105CPQ Dehydrogenase G9272_RS37910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G9272_RS37915 ENOG4106NZI LysR family Transcriptional regulator G9272_RS37965 ENOG4105C5F glutamine synthetase G9272_RS37975 ENOG4108HCJ Hydrolase G9272_RS38000 ENOG4105E5G Alpha beta hydrolase fold G9272_RS38045 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS38070 ENOG4105CNN ABC, transporter G9272_RS38075 ENOG4105C2J ABC transporter G9272_RS38085 ENOG4107QK9 Beta-lactamase G9272_RS38100 ENOG4105CHR reductase G9272_RS38120 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G9272_RS38125 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS38140 ENOG4108QBF Transcriptional regulator G9272_RS38150 ENOG4105JSC dimethylmenaquinone methyltransferase G9272_RS38165 ENOG4105D2S major facilitator superfamily G9272_RS38185 ENOG4105C2J ABC transporter G9272_RS38190 ENOG4105CNN ABC, transporter G9272_RS38195 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9272_RS38200 ENOG4105CR8 Transcriptional regulator G9272_RS38205 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G9272_RS38225 ENOG4107YUH hydrolase G9272_RS38245 ENOG4105C26 Dehydrogenase G9272_RS38250 ENOG4105D5U fad dependent oxidoreductase G9272_RS38260 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G9272_RS38305 ENOG4105CHR reductase G9272_RS38335 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G9272_RS38350 ENOG4105D49 3-dehydroquinate synthase G9272_RS38365 ENOG4105CB2 alcohol dehydrogenase G9272_RS38370 ENOG4106YKD Cytochrome p-450 G9272_RS38375 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G9272_RS38390 ENOG4107XGZ Hydrolase G9272_RS38420 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G9272_RS38425 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G9272_RS38430 ENOG4108M8W Monooxygenase G9272_RS38435 ENOG4105CHR reductase G9272_RS38455 ENOG41085A6 mbth domain-containing protein G9272_RS38465 ENOG4106A3M Cytochrome p-450 G9272_RS38485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G9272_RS38490 ENOG4105D8K carboxyl transferase G9272_RS38495 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS38515 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G9272_RS38530 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G9272_RS38630 ENOG4105DE4 1-phosphofructokinase G9272_RS38665 ENOG4105CDA abc transporter atp-binding protein G9272_RS38675 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G9272_RS38695 ENOG4105DEN Luciferase family G9272_RS38700 ENOG4105CUV Homoserine Kinase G9272_RS38710 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G9272_RS38780 ENOG4105E9K Isocitrate dehydrogenase G9272_RS38790 ENOG4105D64 Mechanosensitive ion channel G9272_RS38805 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9272_RS38810 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein G9272_RS38825 ENOG4105BZ1 (ABC) transporter G9272_RS38835 ENOG4105EYF MMPL domain protein G9272_RS38840 ENOG4105BZU Histidine kinase G9272_RS38845 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS38850 ENOG4107U9T Pfam:Ribonuclease_BN G9272_RS38880 ENOG41061MD high-affinity nickel-transporter G9272_RS38885 ENOG4105ECQ AraC Family Transcriptional Regulator G9272_RS38895 ENOG4108ZFD Antibiotic biosynthesis monooxygenase G9272_RS38905 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G9272_RS38915 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G9272_RS38935 ENOG4107QPH glycogen) synthase G9272_RS38940 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G9272_RS38955 ENOG4108R85 Short chain dehydrogenase G9272_RS38970 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G9272_RS38975 ENOG41073TP transcriptional regulator G9272_RS38980 ENOG4105CHR reductase G9272_RS39045 ENOG4105CRK lysyL-tRNA synthetase G9272_RS39050 ENOG4108ZJ4 polysaccharide deacetylase G9272_RS39090 ENOG4105BZU Histidine kinase G9272_RS39100 ENOG4107RSM transcriptional regulator G9272_RS39110 ENOG4105C5Q Transcriptional regulator G9272_RS39125 ENOG4105E33 succinate dehydrogenase G9272_RS39150 ENOG4105DEN Luciferase family G9272_RS39160 ENOG4105WKW Pfam:DUF1458 G9272_RS39170 ENOG41067HS methyltransferase G9272_RS39175 ENOG4108V75 Glutamine amidotransferase G9272_RS39180 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G9272_RS39200 ENOG4105DZ6 Band 7 protein G9272_RS39245 ENOG4105D7W serine acetyltransferase G9272_RS39270 ENOG4105BZU Histidine kinase G9272_RS39275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS39295 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS39300 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS39355 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G9272_RS39365 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS39380 ENOG41080RH Thioredoxin G9272_RS39390 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G9272_RS39415 ENOG4105Q56 cytochrome P450 G9272_RS39430 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G9272_RS39460 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS39465 ENOG4108ZGX Histidine kinase G9272_RS39495 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G9272_RS39505 ENOG4108W5M transcriptional regulator G9272_RS39570 ENOG4105EUB pirin domain protein G9272_RS39620 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB G9272_RS39635 ENOG4105KVH Transcriptional regulator G9272_RS39640 ENOG41080R8 Conserved Protein G9272_RS39650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G9272_RS39655 ENOG4105DET Rhamnulokinase G9272_RS39670 ENOG4105C2J ABC transporter G9272_RS39675 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane G9272_RS39680 ENOG4105F5R ABC transporter G9272_RS39685 ENOG4105D4B ABC, transporter G9272_RS39700 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS39715 ENOG4105DDN Pentapeptide repeat-containing protein G9272_RS39720 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G9272_RS39725 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G9272_RS39735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G9272_RS39760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G9272_RS39795 ENOG4105DCG PHP domain protein G9272_RS39815 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G9272_RS39825 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G9272_RS39830 ENOG4105C26 Dehydrogenase G9272_RS39845 ENOG4105ECQ AraC Family Transcriptional Regulator G9272_RS39880 ENOG4105CHF Glutathione S-transferase G9272_RS39935 ENOG4105CPC Aldo Keto reductase G9272_RS39965 ENOG4105CNT hydrolase family 2 G9272_RS39995 ENOG4105DMF Dehydrogenase G9272_RS40020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G9272_RS40040 ENOG4108JJA ABC, transporter G9272_RS40045 ENOG4108JJA ABC, transporter G9272_RS40090 ENOG4105CJA serine threonine protein kinase G9272_RS40110 ENOG4107V9E glucose-1-phosphate thymidylyltransferase G9272_RS40145 ENOG4105XRQ Xanthine dehydrogenase accessory factor G9272_RS40175 ENOG4105EX0 alpha-galactosidase G9272_RS40210 ENOG4105CHR reductase G9272_RS40240 ENOG4107FKK extracellular solute-binding protein family 1 G9272_RS40245 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G9272_RS40250 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS40255 ENOG4105DKQ ROK family G9272_RS40280 ENOG4105C87 Aminotransferase class I and II G9272_RS40285 ENOG4105E0S extracellular solute-binding protein family 1 G9272_RS40290 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component G9272_RS40295 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G9272_RS40305 ENOG4105EQX glucarate dehydratase G9272_RS40325 ENOG41067SE Tetr family transcriptional regulator G9272_RS40330 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS40375 ENOG41066F8 ROK family G9272_RS40385 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G9272_RS40390 ENOG4105DRS transport system, permease G9272_RS40405 ENOG4105DBI uridine monophosphokinase G9272_RS40445 ENOG4105CH2 amidohydrolase G9272_RS40475 ENOG4105EYF MMPL domain protein G9272_RS40500 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G9272_RS40520 ENOG4105G9B Transcriptional regulator G9272_RS40540 ENOG4108IV0 ABC, transporter G9272_RS40545 ENOG4105C0Z ABC transporter G9272_RS40550 ENOG4105C32 Amino acid ABC transporter (Permease) G9272_RS40565 ENOG4107SET aldo keto reductase G9272_RS40570 ENOG4105BZ1 (ABC) transporter G9272_RS40595 ENOG4105C7W Xanthine dehydrogenase G9272_RS40600 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G9272_RS40605 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G9272_RS40620 ENOG4105E39 Enoyl-CoA hydratase G9272_RS40635 ENOG4105F27 Major Facilitator G9272_RS40640 ENOG4105F76 Sarcosine oxidase G9272_RS40655 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G9272_RS40670 ENOG4108762 serine threonine protein kinase G9272_RS40685 ENOG4107TTQ Alpha beta hydrolase fold G9272_RS40695 ENOG4105CSR polyphosphate kinase 2 G9272_RS40705 ENOG4107QRI Phosphoketolase G9272_RS40715 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9272_RS40720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS40725 ENOG4105BZU Histidine kinase G9272_RS40765 ENOG4108BAS reductase G9272_RS40770 ENOG4107R13 MMPL domain protein G9272_RS40820 ENOG4108NIW Leucine export protein LeuE G9272_RS40855 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G9272_RS40885 ENOG4105D9P serine threonine protein kinase G9272_RS40890 ENOG4105FQP Beta-lactamase G9272_RS40910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G9272_RS40930 ENOG4105GTG Isochorismatase G9272_RS40935 ENOG4105HSS phospholipase C G9272_RS40960 ENOG4105CBD Diacylglycerol kinase G9272_RS40970 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G9272_RS41005 ENOG4105CPQ Dehydrogenase G9272_RS41030 ENOG4108FN7 Aldo keto reductase G9272_RS41040 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G9272_RS41045 ENOG4107RT4 flavin reductase domain protein G9272_RS41070 ENOG4105DEG Vwa containing coxe family protein G9272_RS41075 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G9272_RS41090 ENOG4107SYN Glycosyl hydrolases family 43 G9272_RS41100 ENOG4105ETX regulatoR G9272_RS41120 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G9272_RS41130 ENOG4105E4C Lytic transglycosylase catalytic G9272_RS41200 ENOG4105C4C beta-galactosidase G9272_RS41210 ENOG4105DRS transport system, permease G9272_RS41220 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS41285 ENOG4105CSR polyphosphate kinase 2 G9272_RS41310 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G9272_RS41320 ENOG4105DPX Hydrogenase, large subunit G9272_RS41350 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G9272_RS41370 ENOG4105CQS hydrogenase expression formation protein HypD G9272_RS41385 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS41415 ENOG4105R0I Feruloyl esterase G9272_RS41430 ENOG4105E0A ABC, transporter G9272_RS41435 ENOG4105J76 Periplasmic binding protein G9272_RS41440 ENOG4105S6R Iron-hydroxamate transporter permease subunit G9272_RS41455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G9272_RS41460 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G9272_RS41465 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS41515 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9272_RS41535 ENOG4105WQI isochorismatase G9272_RS41540 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS41550 ENOG4105EHG Permease protein G9272_RS41555 ENOG4105E0A ABC, transporter G9272_RS41570 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein G9272_RS41575 ENOG4105C32 Amino acid ABC transporter (Permease) G9272_RS41585 ENOG4105C0Z ABC transporter G9272_RS41590 ENOG4108IV0 ABC, transporter G9272_RS41615 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G9272_RS41625 ENOG4108JQ6 ABC transporter G9272_RS41630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G9272_RS41650 ENOG4105D9P serine threonine protein kinase G9272_RS41695 ENOG4106UDK Cellulose-binding, family II G9272_RS41700 ENOG4105EGE secreted protein G9272_RS41705 ENOG4105CHR reductase G9272_RS41710 ENOG4108KB2 LysR family Transcriptional regulator G9272_RS41715 ENOG4105DFW ABC transporter G9272_RS41720 ENOG4108HWW ABC transporter G9272_RS41730 ENOG4105E2R ROK family G9272_RS41745 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) G9272_RS41755 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS41765 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS41795 ENOG4105CEP NADH dehydrogenase G9272_RS41815 ENOG4105BZP glycoside hydrolase 15-related G9272_RS41850 ENOG4107791 aminotransferase class V G9272_RS41855 ENOG4108KEZ Dehydrogenase G9272_RS41895 ENOG4105E2R ROK family G9272_RS41900 ENOG4105EX0 alpha-galactosidase G9272_RS41925 ENOG4105CSR polyphosphate kinase 2 G9272_RS41935 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G9272_RS41975 ENOG4105CEY Amp-dependent synthetase and ligase G9272_RS42050 ENOG4105DIA mandelate racemase muconate lactonizing G9272_RS42055 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS42065 ENOG4105C2J ABC transporter G9272_RS42070 ENOG4105CNN ABC, transporter G9272_RS42075 ENOG4105FDP GntR family transcriptional regulator G9272_RS42090 ENOG4105EYF MMPL domain protein G9272_RS42100 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS42105 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G9272_RS42130 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G9272_RS42150 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS42155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G9272_RS42160 ENOG4105C2J ABC transporter G9272_RS42165 ENOG4107R9N ABC transporter G9272_RS42170 ENOG4105CNN ABC, transporter G9272_RS42180 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G9272_RS42225 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G9272_RS42230 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G9272_RS42235 ENOG4105CG3 alpha amylase, catalytic region G9272_RS42270 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein G9272_RS42305 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G9272_RS42315 ENOG4108RKS Short-chain dehydrogenase reductase Sdr G9272_RS42375 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G9272_RS42380 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G9272_RS42395 ENOG410841Q phosphoesterase PA-phosphatase related protein G9272_RS42415 ENOG4105KVH Transcriptional regulator G9272_RS42430 ENOG4107SET aldo keto reductase G9272_RS42455 ENOG4105DQ4 alcohol dehydrogenase G9272_RS42520 ENOG4105CPQ Dehydrogenase G9272_RS42525 ENOG4105CPQ Dehydrogenase G9272_RS42535 ENOG4107URF beta-phospho-glucomutase G9272_RS42565 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G9272_RS42675 ENOG4105WH1 Two component transcriptional regulator luxr family G9272_RS42680 ENOG4105ENE Histidine kinase G9272_RS42690 ENOG4105CJ1 ABC, transporter G9272_RS42720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G9272_RS42735 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G9272_RS42745 ENOG4107T3P ABC, transporter G9272_RS42750 ENOG4105CG3 alpha amylase, catalytic region G9272_RS42760 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component G9272_RS42765 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G9272_RS42775 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth G9272_RS42785 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G9272_RS42805 ENOG4105GAK amidohydrolase 2 G9272_RS42810 ENOG4105KHM amidohydrolase 2 G9272_RS42815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G9272_RS42820 ENOG4105BZU Histidine kinase G9272_RS42925 ENOG4105CH6 catalase G9272_RS42955 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G9272_RS42975 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G9272_RS43015 ENOG4105D49 3-dehydroquinate synthase G9272_RS43020 ENOG4105E2X shikimate dehydrogenase G9272_RS43025 ENOG4105DVW rieske (2Fe-2S) G9272_RS43060 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G9272_RS43065 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G9272_RS43075 ENOG4105CKK Glycosyl transferase, family 2 G9272_RS43130 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G9272_RS43140 ENOG4106F60 Histidine kinase G9272_RS43145 ENOG4105F44 Two component transcriptional regulator, winged helix family G9272_RS43195 ENOG4105CAQ asparagine synthetase G9272_RS43200 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G9272_RS43310 ENOG4108UMN azlc family G9272_RS43365 ENOG4105KVH Transcriptional regulator G9272_RS43380 ENOG4107R39 (ABC) transporter G9272_RS43445 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G9272_RS43460 ENOG4105VMP Transcriptional regulator G9272_RS43465 ENOG4105EMU Dehydrogenase G9272_RS43485 ENOG4105CHR reductase G9272_RS43535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G9272_RS43540 ENOG4105CPC Aldo Keto reductase G9272_RS43565 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G9272_RS43570 ENOG4105C1G acyl-Coa dehydrogenase G9272_RS43595 ENOG4107RSM transcriptional regulator G9272_RS43615 ENOG4108N3Q Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G9272_RS43625 ENOG4105ETE Transcriptional regulator (LacI family G9272_RS43630 ENOG4105ERH Fumarylacetoacetate hydrolase G9272_RS43635 ENOG4105D2S major facilitator superfamily G9272_RS43640 ENOG4108JQ1 Dehydrogenase G9272_RS43675 ENOG4105D9P serine threonine protein kinase G9272_RS43680 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G9272_RS43690 ENOG4105MSB protein, conserved in bacteria G9272_RS43810 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G9272_RS43815 ENOG4105CPC Aldo Keto reductase G9272_RS43825 ENOG4105EMU Dehydrogenase G9272_RS43885 ENOG4105EMN RNA polymerase sigma factor G9272_RS43905 ENOG4105FDF Could be involved in DNA repair (By similarity) G9272_RS43965 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G9272_RS43995 ENOG4105DF6 Fe-S oxidoreductase G9272_RS44010 ENOG41064MX Tetr family transcriptional regulator G9272_RS44055 ENOG41065KQ synthase G9272_RS44065 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G9272_RS44080 ENOG4105CS1 NAD(P)H quinone oxidoreductase G9272_RS44085 ENOG410680H amp-dependent synthetase and ligase G9272_RS44125 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G9272_RS44130 ENOG4107T4Z adenosine kinase G9272_RS44140 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G9272_RS44195 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G9272_RS44215 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G9272_RS44280 ENOG4106YKD Cytochrome p-450 G9272_RS44290 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G9272_RS44300 ENOG4105JAB phenazine biosynthesis protein, phzf family G9272_RS44325 ENOG4106YKD Cytochrome p-450 G9272_RS44340 ENOG4108HMN Caspase domain G9272_RS44350 ENOG4107STQ Multicopper oxidase G9272_RS44355 ENOG4105C0R drug resistance transporter emrb qaca subfamily G9272_RS44360 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G9272_RS44370 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G9272_RS44400 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G9272_RS44410 ENOG4108TVJ Nitroreductase G9272_RS44460 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G9272_RS44465 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G9272_RS44470 ENOG4105F27 Major Facilitator G9272_RS44480 ENOG4105NRA 50s ribosomal protein l31 type b G9272_RS44495 ENOG4105F7P transcriptional regulator AsnC family