locus-tag	class	description
I6J39_RS00015	COG3293	Transposase
I6J39_RS00150	COG3293	Transposase
I6J39_RS00260	COG1132	(ABC) transporter
I6J39_RS00300	COG2197	response regulator
I6J39_RS00320	COG0583	DNA-binding transcription factor activity
I6J39_RS00335	COG0590	tRNA wobble adenosine to inosine editing
I6J39_RS00350	COG0574	Belongs to the PEP-utilizing enzyme family
I6J39_RS00350	COG3848	Pyruvate phosphate dikinase
I6J39_RS00395	COG4941	Belongs to the sigma-70 factor family
I6J39_RS00405	COG5297	Belongs to the glycosyl hydrolase family 6
I6J39_RS00440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J39_RS00450	COG0477	Major facilitator Superfamily
I6J39_RS00460	COG1846	Transcriptional regulator
I6J39_RS00465	COG1764	response to oxidative stress
I6J39_RS00475	COG0789	Transcriptional regulator
I6J39_RS00500	COG1902	pentaerythritol trinitrate reductase activity
I6J39_RS00505	COG0640	Transcriptional regulator
I6J39_RS00510	COG1064	alcohol dehydrogenase
I6J39_RS00525	COG0702	epimerase
I6J39_RS00540	COG0642	Histidine kinase
I6J39_RS00555	COG2318	DinB family
I6J39_RS00610	COG1349	DNA-binding transcription factor activity
I6J39_RS00645	COG0596	Alpha beta hydrolase
I6J39_RS00675	COG2318	DinB family
I6J39_RS00700	COG0254	rRNA binding
I6J39_RS00705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J39_RS00755	COG1024	Enoyl-CoA hydratase
I6J39_RS00775	COG1132	(ABC) transporter
I6J39_RS00780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J39_RS00795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J39_RS00825	COG2070	2-Nitropropane dioxygenase
I6J39_RS00830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J39_RS00840	COG0515	serine threonine protein kinase
I6J39_RS00845	COG0659	secondary active sulfate transmembrane transporter activity
I6J39_RS00850	COG0789	Transcriptional regulator
I6J39_RS00865	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS00870	COG2813	Specifically methylates the guanine in position
I6J39_RS00885	COG2356	endonuclease I
I6J39_RS00890	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6J39_RS00890	COG2066	Belongs to the glutaminase family
I6J39_RS00900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J39_RS00905	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J39_RS00920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J39_RS00925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J39_RS00930	COG2080	2 iron, 2 sulfur cluster binding
I6J39_RS00975	COG2365	Tyrosine phosphatase family
I6J39_RS01010	COG1120	ATPase activity
I6J39_RS01015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J39_RS01025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS01035	COG0477	Major facilitator Superfamily
I6J39_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS01055	COG1169	isochorismate synthase
I6J39_RS01060	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J39_RS01065	COG3433	isochorismatase activity
I6J39_RS01065	COG1535	isochorismatase
I6J39_RS01070	COG1535	isochorismatase
I6J39_RS01070	COG3433	isochorismatase activity
I6J39_RS01075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J39_RS01095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J39_RS01130	COG3845	ABC transporter
I6J39_RS01150	COG0148	phosphopyruvate hydratase activity
I6J39_RS01170	COG2382	esterase
I6J39_RS01175	COG1132	(ABC) transporter
I6J39_RS01190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J39_RS01195	COG1120	ATPase activity
I6J39_RS01200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01210	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J39_RS01225	COG5002	protein histidine kinase activity
I6J39_RS01230	COG0745	RESPONSE REGULATOR receiver
I6J39_RS01260	COG3559	Exporter of polyketide antibiotics
I6J39_RS01265	COG1131	(ABC) transporter
I6J39_RS01275	COG0587	DNA-directed DNA polymerase activity
I6J39_RS01350	COG1295	ribonuclease BN
I6J39_RS01425	COG4221	oxidoreductase activity
I6J39_RS01440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS01460	COG2376	Dihydroxyacetone kinase
I6J39_RS01465	COG1461	Dihydroxyacetone kinase
I6J39_RS01480	COG0488	(ABC) transporter
I6J39_RS01510	COG1191	sigma factor activity
I6J39_RS01515	COG1309	transcriptional regulator
I6J39_RS01520	COG3246	L-lysine catabolic process to acetate
I6J39_RS01525	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS01540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J39_RS01560	COG1120	ATPase activity
I6J39_RS01565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS01645	COG1295	ribonuclease BN
I6J39_RS01645	COG1959	2 iron, 2 sulfur cluster binding
I6J39_RS01675	COG1120	ATPase activity
I6J39_RS01680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS01720	COG0366	Alpha amylase catalytic
I6J39_RS01720	COG1874	Beta-galactosidase
I6J39_RS01725	COG1609	Transcriptional regulator
I6J39_RS01730	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J39_RS01740	COG1129	ABC transporter
I6J39_RS01745	COG1879	ABC-type sugar transport system periplasmic component
I6J39_RS01800	COG0328	RNA-DNA hybrid ribonuclease activity
I6J39_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS01810	COG1132	(ABC) transporter
I6J39_RS01950	COG5002	protein histidine kinase activity
I6J39_RS01985	COG0464	growth
I6J39_RS01995	COG1349	DNA-binding transcription factor activity
I6J39_RS02010	COG0702	epimerase
I6J39_RS02045	COG1940	carbohydrate kinase activity
I6J39_RS02050	COG2223	nitrite transmembrane transporter activity
I6J39_RS02070	COG0445	tRNA wobble uridine modification
I6J39_RS02080	COG0494	nUDIX hydrolase
I6J39_RS02110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J39_RS02160	COG0584	glycerophosphoryl diester phosphodiesterase
I6J39_RS02180	COG0671	phosphoesterase, PA-phosphatase related
I6J39_RS02225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J39_RS02240	COG2706	6-phosphogluconolactonase activity
I6J39_RS02285	COG3961	Belongs to the TPP enzyme family
I6J39_RS02290	COG2197	response regulator
I6J39_RS02305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J39_RS02310	COG3483	tryptophan 2,3-dioxygenase activity
I6J39_RS02315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J39_RS02335	COG0107	imidazoleglycerol-phosphate synthase activity
I6J39_RS02390	COG2815	serine threonine protein kinase
I6J39_RS02390	COG0515	serine threonine protein kinase
I6J39_RS02395	COG0667	Aldo Keto reductase
I6J39_RS02420	COG1253	flavin adenine dinucleotide binding
I6J39_RS02455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J39_RS02460	COG0531	amino acid
I6J39_RS02470	COG0174	glutamine synthetase
I6J39_RS02475	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS02510	COG4981	capsule polysaccharide biosynthetic process
I6J39_RS02530	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J39_RS02540	COG1802	Transcriptional regulator
I6J39_RS02545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J39_RS02550	COG0402	S-adenosylhomocysteine deaminase activity
I6J39_RS02570	COG0542	response to heat
I6J39_RS02625	COG1335	isochorismatase
I6J39_RS02640	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J39_RS02670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J39_RS02675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J39_RS02680	COG2080	2 iron, 2 sulfur cluster binding
I6J39_RS02710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J39_RS02720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS02775	COG1891	lyase activity
I6J39_RS02790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J39_RS02845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J39_RS02870	COG1309	transcriptional regulator
I6J39_RS02875	COG1982	Orn Lys Arg decarboxylase major
I6J39_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS02895	COG1309	transcriptional regulator
I6J39_RS02950	COG2814	Major facilitator Superfamily
I6J39_RS02970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J39_RS03015	COG1959	2 iron, 2 sulfur cluster binding
I6J39_RS03040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J39_RS03050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J39_RS03055	COG1116	anion transmembrane transporter activity
I6J39_RS03070	COG2072	flavoprotein involved in K transport
I6J39_RS03075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J39_RS03085	COG1132	(ABC) transporter
I6J39_RS03090	COG1846	Transcriptional regulator
I6J39_RS03095	COG0277	FAD linked oxidase domain protein
I6J39_RS03100	COG0673	inositol 2-dehydrogenase activity
I6J39_RS03105	COG1132	(ABC) transporter
I6J39_RS03110	COG1132	(ABC) transporter
I6J39_RS03130	COG1793	dna ligase
I6J39_RS03145	COG1946	Acyl-CoA thioesterase
I6J39_RS03160	COG0386	Belongs to the glutathione peroxidase family
I6J39_RS03165	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS03175	COG0242	peptide deformylase activity
I6J39_RS03185	COG3442	glutamine amidotransferase
I6J39_RS03190	COG0205	6-phosphofructokinase activity
I6J39_RS03205	COG0204	Acyl-transferase
I6J39_RS03220	COG0829	nickel cation binding
I6J39_RS03225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J39_RS03235	COG0804	urea catabolic process
I6J39_RS03240	COG0832	Belongs to the urease beta subunit family
I6J39_RS03245	COG0831	urea catabolic process
I6J39_RS03250	COG1309	transcriptional regulator
I6J39_RS03265	COG0740	serine-type endopeptidase activity
I6J39_RS03280	COG1280	lysine exporter protein (LysE YggA)
I6J39_RS03285	COG0583	DNA-binding transcription factor activity
I6J39_RS03305	COG0156	8-amino-7-oxononanoate synthase activity
I6J39_RS03310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J39_RS03315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J39_RS03320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J39_RS03365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J39_RS03375	COG1940	carbohydrate kinase activity
I6J39_RS03380	COG2188	Transcriptional regulator
I6J39_RS03385	COG1595	DNA-templated transcription, initiation
I6J39_RS03400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J39_RS03425	COG0626	cystathionine gamma-synthase activity
I6J39_RS03445	COG0419	ATPase involved in DNA repair
I6J39_RS03450	COG0420	3'-5' exonuclease activity
I6J39_RS03455	COG1739	Uncharacterized protein family UPF0029
I6J39_RS03460	COG1832	CoA-binding protein
I6J39_RS03500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J39_RS03520	COG1968	undecaprenyl-diphosphatase activity
I6J39_RS03550	COG2226	methyltransferase
I6J39_RS03615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J39_RS03675	COG0069	glutamate synthase activity
I6J39_RS03730	COG0477	Major facilitator Superfamily
I6J39_RS03745	COG0784	Response regulator, receiver
I6J39_RS03750	COG4251	negative regulation of phosphorylation
I6J39_RS03755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J39_RS03765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J39_RS03775	COG1215	transferase activity, transferring glycosyl groups
I6J39_RS03795	COG1396	sequence-specific DNA binding
I6J39_RS03795	COG3800	Transcriptional regulator
I6J39_RS03895	COG1695	Transcriptional regulator
I6J39_RS03920	COG1595	DNA-templated transcription, initiation
I6J39_RS03975	COG0384	phenazine biosynthesis protein PhzF
I6J39_RS04005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J39_RS04005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J39_RS04015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J39_RS04035	COG1716	ATPase activity
I6J39_RS04055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J39_RS04085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J39_RS04095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J39_RS04110	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J39_RS04140	COG2018	Roadblock/LC7 domain
I6J39_RS04205	COG2364	Membrane
I6J39_RS04215	COG2270	Major facilitator Superfamily
I6J39_RS04230	COG1216	Glycosyl transferase, family 2
I6J39_RS04250	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS04255	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS04265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J39_RS04310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J39_RS04315	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J39_RS04320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J39_RS04325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J39_RS04325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J39_RS04330	COG3201	nicotinamide mononucleotide transporter
I6J39_RS04355	COG0738	Major facilitator superfamily
I6J39_RS04360	COG2233	PERMEase
I6J39_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS04385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J39_RS04405	COG0142	geranyltranstransferase activity
I6J39_RS04420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J39_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS04445	COG2390	Transcriptional regulator
I6J39_RS04450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J39_RS04460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J39_RS04475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J39_RS04485	COG1758	RNA polymerase activity
I6J39_RS04500	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J39_RS04505	COG0167	dihydroorotate dehydrogenase activity
I6J39_RS04510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J39_RS04515	COG0505	Belongs to the CarA family
I6J39_RS04525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J39_RS04530	COG0540	Belongs to the ATCase OTCase family
I6J39_RS04535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J39_RS04545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J39_RS04550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J39_RS04555	COG0006	proline dipeptidase activity
I6J39_RS04565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J39_RS04570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J39_RS04575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J39_RS04580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J39_RS04590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J39_RS04595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J39_RS04615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J39_RS04635	COG0124	histidyl-tRNA synthetase
I6J39_RS04650	COG1196	nuclear chromosome segregation
I6J39_RS04670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J39_RS04675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J39_RS04680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J39_RS04685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J39_RS04695	COG2255	four-way junction helicase activity
I6J39_RS04700	COG0632	four-way junction helicase activity
I6J39_RS04705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J39_RS04710	COG0217	transcriptional regulatory protein
I6J39_RS04715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J39_RS04720	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J39_RS04730	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS04735	COG1560	Kdo2-lipid A biosynthetic process
I6J39_RS04740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J39_RS04760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J39_RS04775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J39_RS04835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J39_RS04890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J39_RS04890	COG1648	precorrin-2 dehydrogenase activity
I6J39_RS04895	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J39_RS04910	COG1464	Belongs to the NlpA lipoprotein family
I6J39_RS04915	COG2011	ABC-type metal ion transport system permease component
I6J39_RS04955	COG0477	Major facilitator Superfamily
I6J39_RS04965	COG3973	AAA domain
I6J39_RS04975	COG0165	Argininosuccinate lyase
I6J39_RS04980	COG0137	argininosuccinate synthase activity
I6J39_RS04995	COG1438	arginine binding
I6J39_RS05000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J39_RS05005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J39_RS05010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J39_RS05015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J39_RS05075	COG0697	spore germination
I6J39_RS05085	COG1649	PFAM Uncharacterised BCR, COG1649
I6J39_RS05110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J39_RS05110	COG0072	phenylalanine-tRNA ligase activity
I6J39_RS05115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J39_RS05120	COG5002	protein histidine kinase activity
I6J39_RS05125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J39_RS05130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J39_RS05135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J39_RS05140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J39_RS05150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J39_RS05205	COG0517	IMP dehydrogenase activity
I6J39_RS05205	COG4175	Glycine betaine
I6J39_RS05210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J39_RS05240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J39_RS05245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J39_RS05285	COG0805	protein transport
I6J39_RS05290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J39_RS05310	COG2378	regulation of single-species biofilm formation
I6J39_RS05320	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J39_RS05325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J39_RS05335	COG1609	Transcriptional regulator
I6J39_RS05340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J39_RS05345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J39_RS05355	COG4122	O-methyltransferase activity
I6J39_RS05360	COG1222	aaa ATPase
I6J39_RS05380	COG0517	IMP dehydrogenase activity
I6J39_RS05380	COG1994	Peptidase M50
I6J39_RS05390	COG2197	response regulator
I6J39_RS05395	COG4166	transmembrane transport
I6J39_RS05400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS05405	COG0646	methionine synthase
I6J39_RS05405	COG1410	methionine synthase
I6J39_RS05410	COG1414	Transcriptional regulator
I6J39_RS05415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J39_RS05420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J39_RS05425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J39_RS05430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS05440	COG0215	cysteine-tRNA ligase activity
I6J39_RS05460	COG0598	Magnesium transport protein CorA
I6J39_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS05475	COG0667	Aldo Keto reductase
I6J39_RS05505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J39_RS05515	COG0564	pseudouridine synthase activity
I6J39_RS05530	COG2186	Transcriptional regulator
I6J39_RS05535	COG3265	gluconokinase activity
I6J39_RS05565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J39_RS05570	COG2149	membrane
I6J39_RS05590	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS05595	COG4935	Belongs to the peptidase S8 family
I6J39_RS05595	COG2234	aminopeptidase activity
I6J39_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS05615	COG3876	Protein conserved in bacteria
I6J39_RS05650	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS05665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J39_RS05675	COG2318	DinB family
I6J39_RS05685	COG2851	Citrate transporter
I6J39_RS05690	COG1309	transcriptional regulator
I6J39_RS05710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6J39_RS05715	COG2188	Transcriptional regulator
I6J39_RS05725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J39_RS05735	COG2755	lipolytic protein G-D-S-L family
I6J39_RS05745	COG1725	Transcriptional regulator
I6J39_RS05760	COG0346	lactoylglutathione lyase activity
I6J39_RS05780	COG4565	transcriptional regulatory protein
I6J39_RS05815	COG4585	Histidine kinase
I6J39_RS05820	COG2197	response regulator
I6J39_RS05840	COG0641	radical SAM
I6J39_RS05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS05880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS05885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS05890	COG1126	abc transporter atp-binding protein
I6J39_RS05905	COG0765	amino acid transport
I6J39_RS05910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS05920	COG1799	cell septum assembly
I6J39_RS05925	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS05930	COG0477	Major facilitator Superfamily
I6J39_RS05935	COG0671	phosphoesterase, PA-phosphatase related
I6J39_RS05950	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS05965	COG1160	GTP binding
I6J39_RS05975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J39_RS06000	COG0494	nUDIX hydrolase
I6J39_RS06015	COG1187	pseudouridine synthase activity
I6J39_RS06020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J39_RS06025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J39_RS06040	COG0686	Belongs to the AlaDH PNT family
I6J39_RS06050	COG0494	nUDIX hydrolase
I6J39_RS06055	COG0504	CTP synthase activity
I6J39_RS06060	COG3387	PFAM Glycoside hydrolase 15-related
I6J39_RS06085	COG0497	DNA recombination
I6J39_RS06090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J39_RS06110	COG1120	ATPase activity
I6J39_RS06115	COG0647	UMP catabolic process
I6J39_RS06150	COG2094	Belongs to the DNA glycosylase MPG family
I6J39_RS06160	COG1881	PFAM PEBP family protein
I6J39_RS06185	COG1119	ATPase activity
I6J39_RS06195	COG2197	response regulator
I6J39_RS06200	COG4585	Histidine kinase
I6J39_RS06210	COG1716	ATPase activity
I6J39_RS06210	COG0842	Transport permease protein
I6J39_RS06210	COG1131	(ABC) transporter
I6J39_RS06215	COG0560	Phosphoserine phosphatase
I6J39_RS06215	COG3830	Belongs to the UPF0237 family
I6J39_RS06245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J39_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS06275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J39_RS06280	COG2261	transglycosylase associated protein
I6J39_RS06295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J39_RS06300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J39_RS06340	COG3387	PFAM Glycoside hydrolase 15-related
I6J39_RS06380	COG1024	Enoyl-CoA hydratase
I6J39_RS06390	COG0488	(ABC) transporter
I6J39_RS06415	COG0235	Class ii aldolase
I6J39_RS06430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J39_RS06435	COG1492	cobalamin metabolic process
I6J39_RS06450	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J39_RS06475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J39_RS06505	COG1902	pentaerythritol trinitrate reductase activity
I6J39_RS06555	COG4585	Histidine kinase
I6J39_RS06560	COG2197	response regulator
I6J39_RS06565	COG0768	penicillin binding
I6J39_RS06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J39_RS06610	COG2171	N-acyltransferase activity
I6J39_RS06615	COG3226	Transcriptional regulator
I6J39_RS06630	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J39_RS06635	COG0822	iron-sulfur transferase activity
I6J39_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J39_RS06645	COG0396	ATPase activity
I6J39_RS06655	COG0719	Fe-S assembly protein
I6J39_RS06690	COG0109	protoheme IX farnesyltransferase activity
I6J39_RS06700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J39_RS06715	COG0363	glucosamine-6-phosphate deaminase activity
I6J39_RS06725	COG4195	phage-related replication protein
I6J39_RS06740	COG0166	Belongs to the GPI family
I6J39_RS06750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J39_RS06755	COG0149	triose-phosphate isomerase activity
I6J39_RS06760	COG0126	phosphoglycerate kinase activity
I6J39_RS06765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J39_RS06770	COG1481	regulation of sporulation
I6J39_RS06775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J39_RS06780	COG1660	Displays ATPase and GTPase activities
I6J39_RS06785	COG0322	excinuclease ABC activity
I6J39_RS06810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J39_RS06840	COG0556	nucleotide-excision repair
I6J39_RS06850	COG0584	glycerophosphoryl diester phosphodiesterase
I6J39_RS06860	COG2814	Major facilitator Superfamily
I6J39_RS06870	COG2313	pseudouridylate synthase activity
I6J39_RS06890	COG0436	Aminotransferase
I6J39_RS06910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J39_RS06920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J39_RS06940	COG0237	dephospho-CoA kinase activity
I6J39_RS06965	COG1643	Atp-dependent helicase
I6J39_RS07000	COG2050	protein possibly involved in aromatic compounds catabolism
I6J39_RS07010	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J39_RS07055	COG0737	Belongs to the 5'-nucleotidase family
I6J39_RS07090	COG1605	Chorismate mutase
I6J39_RS07090	COG0287	Prephenate dehydrogenase
I6J39_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS07130	COG1024	Enoyl-CoA hydratase
I6J39_RS07155	COG1278	Cold shock
I6J39_RS07160	COG0183	Belongs to the thiolase family
I6J39_RS07165	COG1309	transcriptional regulator
I6J39_RS07175	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS07205	COG0705	Rhomboid family
I6J39_RS07215	COG0067	glutamate synthase
I6J39_RS07215	COG0069	glutamate synthase activity
I6J39_RS07215	COG0070	glutamate synthase
I6J39_RS07245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J39_RS07250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J39_RS07260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J39_RS07270	COG0159	tryptophan synthase activity
I6J39_RS07275	COG0133	tryptophan synthase activity
I6J39_RS07285	COG0134	indole-3-glycerol-phosphate synthase activity
I6J39_RS07305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J39_RS07310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J39_RS07330	COG0107	imidazoleglycerol-phosphate synthase activity
I6J39_RS07335	COG0251	oxidation-reduction process
I6J39_RS07340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J39_RS07345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J39_RS07355	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J39_RS07360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J39_RS07365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J39_RS07385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J39_RS07410	COG1432	Conserved Protein
I6J39_RS07420	COG0587	DNA-directed DNA polymerase activity
I6J39_RS07465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J39_RS07475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J39_RS07480	COG3599	regulation of cell shape
I6J39_RS07490	COG1799	cell septum assembly
I6J39_RS07495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J39_RS07515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J39_RS07525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J39_RS07530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J39_RS07540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J39_RS07545	COG0768	penicillin binding
I6J39_RS07555	COG0275	rRNA processing
I6J39_RS07565	COG0714	Associated with various cellular activities
I6J39_RS07585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J39_RS07595	COG0577	efflux transmembrane transporter activity
I6J39_RS07595	COG1136	(ABC) transporter
I6J39_RS07615	COG1233	COG1233 Phytoene dehydrogenase and related
I6J39_RS07630	COG0352	thiamine-phosphate diphosphorylase activity
I6J39_RS07650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J39_RS07650	COG2022	thiamine diphosphate biosynthetic process
I6J39_RS07660	COG2022	thiamine diphosphate biosynthetic process
I6J39_RS07665	COG0515	serine threonine protein kinase
I6J39_RS07665	COG2815	serine threonine protein kinase
I6J39_RS07670	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J39_RS07675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J39_RS07680	COG2193	ferroxidase activity
I6J39_RS07690	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J39_RS07705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J39_RS07710	COG2197	response regulator
I6J39_RS07740	COG1940	carbohydrate kinase activity
I6J39_RS07750	COG0003	Pfam Anion-transporting ATPase
I6J39_RS07765	COG1022	Amp-dependent synthetase and ligase
I6J39_RS07815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J39_RS07820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J39_RS07825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J39_RS07830	COG0723	plastoquinol--plastocyanin reductase activity
I6J39_RS07835	COG2010	Cytochrome c
I6J39_RS07840	COG1845	cytochrome c oxidase, subunit III
I6J39_RS07850	COG1376	ErfK ybiS ycfS ynhG family protein
I6J39_RS07860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J39_RS07865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J39_RS07875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J39_RS07895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J39_RS07905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J39_RS07910	COG2197	response regulator
I6J39_RS07915	COG4585	Histidine kinase
I6J39_RS07940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J39_RS07955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J39_RS07970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J39_RS07975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J39_RS07980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J39_RS07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J39_RS07995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J39_RS08015	COG1090	epimerase
I6J39_RS08035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J39_RS08060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J39_RS08065	COG3896	Chloramphenicol phosphotransferase-like protein
I6J39_RS08095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J39_RS08100	COG0673	inositol 2-dehydrogenase activity
I6J39_RS08120	COG0745	RESPONSE REGULATOR receiver
I6J39_RS08125	COG2409	Drug exporters of the RND superfamily
I6J39_RS08130	COG4585	Histidine kinase
I6J39_RS08135	COG2197	response regulator
I6J39_RS08195	COG0366	Alpha amylase catalytic
I6J39_RS08200	COG0395	ABC-type sugar transport system, permease component
I6J39_RS08210	COG2182	Extracellular solute-binding protein
I6J39_RS08215	COG1609	Transcriptional regulator
I6J39_RS08225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J39_RS08230	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J39_RS08235	COG0477	Major facilitator Superfamily
I6J39_RS08275	COG0494	nUDIX hydrolase
I6J39_RS08290	COG0174	glutamine synthetase
I6J39_RS08305	COG2132	Multicopper oxidase
I6J39_RS08310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J39_RS08310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J39_RS08315	COG2814	Major facilitator Superfamily
I6J39_RS08330	COG0477	Major facilitator Superfamily
I6J39_RS08335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J39_RS08355	COG1994	Peptidase M50
I6J39_RS08415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS08420	COG1120	ATPase activity
I6J39_RS08440	COG1834	amidinotransferase
I6J39_RS08455	COG2814	Major facilitator Superfamily
I6J39_RS08465	COG3540	Alkaline phosphatase
I6J39_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS08480	COG0384	phenazine biosynthesis protein PhzF
I6J39_RS08520	COG2273	Hydrolase Family 16
I6J39_RS08545	COG3022	response to hydroperoxide
I6J39_RS08550	COG0800	Aldolase
I6J39_RS08565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J39_RS08570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J39_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS08595	COG2030	dehydratase
I6J39_RS08605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J39_RS08610	COG0183	Belongs to the thiolase family
I6J39_RS08615	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS08625	COG3340	Belongs to the peptidase S51 family
I6J39_RS08640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J39_RS08645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J39_RS08665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS08690	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS08695	COG1309	transcriptional regulator
I6J39_RS08750	COG3845	ABC transporter
I6J39_RS08765	COG0183	Belongs to the thiolase family
I6J39_RS08770	COG2124	cytochrome p450
I6J39_RS08815	COG2259	Doxx family
I6J39_RS08890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J39_RS08895	COG2188	Transcriptional regulator
I6J39_RS08950	COG0582	viral genome integration into host DNA
I6J39_RS08985	COG1358	cellular component organization or biogenesis
I6J39_RS09030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J39_RS09040	COG0477	Major facilitator Superfamily
I6J39_RS09045	COG1309	transcriptional regulator
I6J39_RS09060	COG4585	Histidine kinase
I6J39_RS09065	COG2197	response regulator
I6J39_RS09080	COG0667	Aldo Keto reductase
I6J39_RS09085	COG0789	Transcriptional regulator
I6J39_RS09095	COG2205	protein histidine kinase activity
I6J39_RS09100	COG0745	RESPONSE REGULATOR receiver
I6J39_RS09110	COG0667	Aldo Keto reductase
I6J39_RS09120	COG1929	Belongs to the glycerate kinase type-1 family
I6J39_RS09195	COG1674	ftsk spoiiie
I6J39_RS09200	COG1404	Belongs to the peptidase S8 family
I6J39_RS09255	COG2957	Belongs to the agmatine deiminase family
I6J39_RS09260	COG0456	acetyltransferase
I6J39_RS09270	COG1741	Belongs to the pirin family
I6J39_RS09315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J39_RS09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS09325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS09350	COG1764	response to oxidative stress
I6J39_RS09355	COG2130	NADP-dependent
I6J39_RS09385	COG1522	sequence-specific DNA binding
I6J39_RS09395	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS09400	COG0825	malonyl-CoA metabolic process
I6J39_RS09400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J39_RS09405	COG0477	Major facilitator Superfamily
I6J39_RS09430	COG1070	Carbohydrate kinase
I6J39_RS09445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J39_RS09450	COG0358	DNA primase activity
I6J39_RS09460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J39_RS09470	COG2949	membrane
I6J39_RS09515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J39_RS09515	COG2146	nitrite reductase [NAD(P)H] activity
I6J39_RS09540	COG0574	Belongs to the PEP-utilizing enzyme family
I6J39_RS09540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J39_RS09545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS09550	COG3842	ATPase activity
I6J39_RS09570	COG2188	Transcriptional regulator
I6J39_RS09600	COG0477	Major facilitator Superfamily
I6J39_RS09605	COG2066	Belongs to the glutaminase family
I6J39_RS09620	COG1309	transcriptional regulator
I6J39_RS09750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J39_RS09765	COG0277	FAD linked oxidase domain protein
I6J39_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS09775	COG2124	cytochrome p450
I6J39_RS09810	COG0477	Major facilitator Superfamily
I6J39_RS09815	COG2345	Transcriptional regulator
I6J39_RS09840	COG0367	asparagine synthase
I6J39_RS09850	COG0662	Cupin 2, conserved barrel domain protein
I6J39_RS09855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS09860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS09885	COG3104	oligopeptide transport
I6J39_RS09895	COG0423	glycine-tRNA ligase activity
I6J39_RS09905	COG1121	(ABC) transporter
I6J39_RS09910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J39_RS09920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J39_RS09925	COG1381	Involved in DNA repair and RecF pathway recombination
I6J39_RS09935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J39_RS09950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J39_RS09965	COG2315	Protein conserved in bacteria
I6J39_RS09975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J39_RS09985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J39_RS09985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J39_RS09995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J39_RS10000	COG1234	tRNA 3'-trailer cleavage
I6J39_RS10005	COG0537	adenosine 5'-monophosphoramidase activity
I6J39_RS10020	COG0484	heat shock protein binding
I6J39_RS10025	COG1420	regulation of RNA biosynthetic process
I6J39_RS10065	COG0481	GTPase activity
I6J39_RS10070	COG0268	Binds directly to 16S ribosomal RNA
I6J39_RS10095	COG1234	tRNA 3'-trailer cleavage
I6J39_RS10100	COG1555	photosystem II stabilization
I6J39_RS10105	COG1307	EDD domain protein, DegV family
I6J39_RS10115	COG0495	leucyl-tRNA aminoacylation
I6J39_RS10135	COG0588	phosphoglycerate mutase activity
I6J39_RS10140	COG0799	negative regulation of ribosome biogenesis
I6J39_RS10150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J39_RS10165	COG0501	Belongs to the peptidase M48B family
I6J39_RS10180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J39_RS10190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J39_RS10215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J39_RS10220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J39_RS10225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J39_RS10230	COG1530	ribonuclease E activity
I6J39_RS10255	COG0772	Belongs to the SEDS family
I6J39_RS10260	COG0768	penicillin binding
I6J39_RS10275	COG1077	Cell shape determining protein MreB Mrl
I6J39_RS10280	COG0105	UTP biosynthetic process
I6J39_RS10290	COG0285	dihydrofolate synthase activity
I6J39_RS10295	COG0525	valine-tRNA ligase activity
I6J39_RS10305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J39_RS10310	COG0740	serine-type endopeptidase activity
I6J39_RS10315	COG0740	serine-type endopeptidase activity
I6J39_RS10320	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J39_RS10340	COG3594	Acyltransferase
I6J39_RS10350	COG0475	glutathione-regulated potassium exporter activity
I6J39_RS10370	COG1113	amino acid transport
I6J39_RS10380	COG1268	BioY protein
I6J39_RS10385	COG1113	amino acid transport
I6J39_RS10395	COG0584	glycerophosphoryl diester phosphodiesterase
I6J39_RS10400	COG0783	Belongs to the Dps family
I6J39_RS10410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J39_RS10415	COG0640	Transcriptional regulator
I6J39_RS10430	COG0110	maltose O-acetyltransferase activity
I6J39_RS10435	COG1404	Belongs to the peptidase S8 family
I6J39_RS10450	COG2252	PERMEase
I6J39_RS10460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J39_RS10485	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J39_RS10510	COG4266	Belongs to the allantoicase family
I6J39_RS10515	COG0583	DNA-binding transcription factor activity
I6J39_RS10535	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J39_RS10535	COG3291	Pkd domain containing protein
I6J39_RS10545	COG0668	transmembrane transport
I6J39_RS10565	COG1940	carbohydrate kinase activity
I6J39_RS10575	COG1175	transmembrane transport
I6J39_RS10580	COG0395	ABC-type sugar transport system, permease component
I6J39_RS10585	COG1486	melibiose metabolic process
I6J39_RS10600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS10630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J39_RS10650	COG0577	efflux transmembrane transporter activity
I6J39_RS10650	COG1136	(ABC) transporter
I6J39_RS10675	COG0629	single-stranded DNA binding
I6J39_RS10710	COG1674	ftsk spoiiie
I6J39_RS10810	COG4585	Histidine kinase
I6J39_RS10830	COG3962	Belongs to the TPP enzyme family
I6J39_RS10835	COG3718	enzyme involved in inositol metabolism
I6J39_RS10845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J39_RS10855	COG2318	DinB family
I6J39_RS10895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J39_RS10920	COG0596	Alpha beta hydrolase
I6J39_RS10970	COG0673	inositol 2-dehydrogenase activity
I6J39_RS10975	COG1609	Transcriptional regulator
I6J39_RS11010	COG0515	serine threonine protein kinase
I6J39_RS11045	COG1404	Belongs to the peptidase S8 family
I6J39_RS11070	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J39_RS11085	COG0477	Major facilitator Superfamily
I6J39_RS11115	COG0028	Belongs to the TPP enzyme family
I6J39_RS11150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J39_RS11175	COG1946	Acyl-CoA thioesterase
I6J39_RS11205	COG1309	transcriptional regulator
I6J39_RS11210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J39_RS11225	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS11245	COG0076	glutamate decarboxylase activity
I6J39_RS11250	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J39_RS11275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J39_RS11285	COG4977	sequence-specific DNA binding
I6J39_RS11320	COG0395	ABC-type sugar transport system, permease component
I6J39_RS11335	COG2985	domain, Protein
I6J39_RS11350	COG0745	RESPONSE REGULATOR receiver
I6J39_RS11425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS11435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J39_RS11445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS11450	COG0765	amino acid transport
I6J39_RS11455	COG0765	amino acid transport
I6J39_RS11460	COG1126	abc transporter atp-binding protein
I6J39_RS11465	COG1414	Transcriptional regulator
I6J39_RS11475	COG3397	chitin binding
I6J39_RS11540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J39_RS11545	COG2188	Transcriptional regulator
I6J39_RS11555	COG1940	carbohydrate kinase activity
I6J39_RS11560	COG0673	inositol 2-dehydrogenase activity
I6J39_RS11565	COG4702	Belongs to the UPF0303 family
I6J39_RS11570	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J39_RS11575	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
I6J39_RS11575	COG0706	membrane insertase activity
I6J39_RS11585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J39_RS11595	COG3764	Sortase (surface protein transpeptidase)
I6J39_RS11635	COG3655	Transcriptional regulator
I6J39_RS11665	COG3135	benzoate transporter
I6J39_RS11670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J39_RS11685	COG2175	clavaminate synthase activity
I6J39_RS11695	COG0596	Alpha beta hydrolase
I6J39_RS11705	COG2733	membrane
I6J39_RS11720	COG4555	ABC transporter
I6J39_RS11735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J39_RS11760	COG0477	Major facilitator Superfamily
I6J39_RS11780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J39_RS11790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J39_RS11795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J39_RS11800	COG1263	PTS System
I6J39_RS11805	COG1263	PTS System
I6J39_RS11815	COG1234	tRNA 3'-trailer cleavage
I6J39_RS11840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS11855	COG1113	amino acid transport
I6J39_RS11865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J39_RS11875	COG1335	isochorismatase
I6J39_RS11910	COG0277	FAD linked oxidase domain protein
I6J39_RS11920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J39_RS11930	COG1174	glycine betaine transport
I6J39_RS11935	COG0517	IMP dehydrogenase activity
I6J39_RS11935	COG1125	glycine betaine transport
I6J39_RS11940	COG1174	glycine betaine transport
I6J39_RS11945	COG1732	Glycine betaine
I6J39_RS11965	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J39_RS12000	COG3654	unkown
I6J39_RS12060	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J39_RS12065	COG0395	ABC-type sugar transport system, permease component
I6J39_RS12075	COG2182	Extracellular solute-binding protein
I6J39_RS12085	COG1678	Uncharacterized ACR, COG1678
I6J39_RS12090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J39_RS12095	COG0776	regulation of translation
I6J39_RS12105	COG3973	AAA domain
I6J39_RS12105	COG3973	AAA domain
I6J39_RS12130	COG2223	nitrite transmembrane transporter activity
I6J39_RS12135	COG0583	DNA-binding transcription factor activity
I6J39_RS12180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J39_RS12185	COG0793	Belongs to the peptidase S41A family
I6J39_RS12190	COG2177	Part of the ABC transporter FtsEX involved in
I6J39_RS12195	COG2884	Cell division ATP-binding protein ftsE
I6J39_RS12210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J39_RS12215	COG0515	serine threonine protein kinase
I6J39_RS12220	COG0515	serine threonine protein kinase
I6J39_RS12230	COG1653	transport
I6J39_RS12235	COG1175	transmembrane transport
I6J39_RS12240	COG0395	ABC-type sugar transport system, permease component
I6J39_RS12245	COG1216	Glycosyl transferase, family 2
I6J39_RS12245	COG1442	glycosyl transferase family 8
I6J39_RS12250	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS12255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J39_RS12260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J39_RS12265	COG4122	O-methyltransferase activity
I6J39_RS12270	COG2226	methyltransferase
I6J39_RS12270	COG1073	alpha beta
I6J39_RS12275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J39_RS12280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J39_RS12290	COG1309	transcriptional regulator
I6J39_RS12300	COG1134	teichoic acid transport
I6J39_RS12305	COG2902	Dehydrogenase
I6J39_RS12325	COG0653	protein targeting
I6J39_RS12340	COG2197	response regulator
I6J39_RS12345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J39_RS12355	COG0823	Involved in the tonB-independent uptake of proteins
I6J39_RS12360	COG5002	protein histidine kinase activity
I6J39_RS12360	COG5000	phosphorelay sensor kinase activity
I6J39_RS12365	COG0745	RESPONSE REGULATOR receiver
I6J39_RS12445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J39_RS12465	COG0714	Associated with various cellular activities
I6J39_RS12505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J39_RS12525	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J39_RS12530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J39_RS12565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J39_RS12570	COG0778	Nitroreductase
I6J39_RS12570	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J39_RS12575	COG0531	amino acid
I6J39_RS12600	COG1316	TRANSCRIPTIONal
I6J39_RS12605	COG1316	TRANSCRIPTIONal
I6J39_RS12610	COG1316	TRANSCRIPTIONal
I6J39_RS12615	COG1316	TRANSCRIPTIONal
I6J39_RS12625	COG1316	TRANSCRIPTIONal
I6J39_RS12725	COG2205	protein histidine kinase activity
I6J39_RS12730	COG0745	RESPONSE REGULATOR receiver
I6J39_RS12735	COG3104	oligopeptide transport
I6J39_RS12765	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J39_RS12770	COG1191	sigma factor activity
I6J39_RS12775	COG1228	amidohydrolase
I6J39_RS12785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J39_RS12790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J39_RS12795	COG0531	amino acid
I6J39_RS12835	COG2755	lipolytic protein G-D-S-L family
I6J39_RS12840	COG0183	Belongs to the thiolase family
I6J39_RS12865	COG1136	(ABC) transporter
I6J39_RS12870	COG1136	(ABC) transporter
I6J39_RS12870	COG0577	efflux transmembrane transporter activity
I6J39_RS12875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J39_RS12880	COG1252	NADH dehydrogenase
I6J39_RS12900	COG0148	phosphopyruvate hydratase activity
I6J39_RS12910	COG1652	LysM domain
I6J39_RS12935	COG2815	serine threonine protein kinase
I6J39_RS12935	COG0515	serine threonine protein kinase
I6J39_RS12955	COG1335	isochorismatase
I6J39_RS13000	COG1473	amidohydrolase
I6J39_RS13055	COG3903	Transcriptional regulator
I6J39_RS13055	COG3629	intracellular signal transduction
I6J39_RS13065	COG0577	efflux transmembrane transporter activity
I6J39_RS13070	COG1136	(ABC) transporter
I6J39_RS13075	COG0477	Major facilitator Superfamily
I6J39_RS13080	COG0346	lactoylglutathione lyase activity
I6J39_RS13125	COG2124	cytochrome p450
I6J39_RS13155	COG2226	methyltransferase
I6J39_RS13170	COG4585	Histidine kinase
I6J39_RS13180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J39_RS13185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J39_RS13190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J39_RS13195	COG0193	aminoacyl-tRNA hydrolase activity
I6J39_RS13200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J39_RS13225	COG4106	trans-aconitate 2-methyltransferase activity
I6J39_RS13230	COG1846	Transcriptional regulator
I6J39_RS13235	COG2197	response regulator
I6J39_RS13245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J39_RS13260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J39_RS13285	COG0488	(ABC) transporter
I6J39_RS13305	COG2161	toxin-antitoxin pair type II binding
I6J39_RS13310	COG4115	mRNA cleavage
I6J39_RS13325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J39_RS13330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J39_RS13335	COG0084	hydrolase, TatD family'
I6J39_RS13365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J39_RS13410	COG2223	nitrite transmembrane transporter activity
I6J39_RS13415	COG2207	Transcriptional regulator
I6J39_RS13420	COG0442	prolyl-tRNA aminoacylation
I6J39_RS13440	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I6J39_RS13445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J39_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS13470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J39_RS13480	COG2409	Drug exporters of the RND superfamily
I6J39_RS13490	COG0793	Belongs to the peptidase S41A family
I6J39_RS13490	COG4946	Tricorn protease homolog
I6J39_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS13510	COG2072	flavoprotein involved in K transport
I6J39_RS13520	COG0708	Exodeoxyribonuclease III
I6J39_RS13550	COG2340	Cysteine-rich secretory protein family
I6J39_RS13570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J39_RS13590	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J39_RS13595	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J39_RS13605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J39_RS13610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J39_RS13635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J39_RS13660	COG0437	4 iron, 4 sulfur cluster binding
I6J39_RS13665	COG0243	molybdopterin cofactor binding
I6J39_RS13685	COG0477	Major facilitator Superfamily
I6J39_RS13705	COG3384	dioxygenase
I6J39_RS13710	COG1846	Transcriptional regulator
I6J39_RS13730	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS13790	COG1686	Belongs to the peptidase S11 family
I6J39_RS13895	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J39_RS13910	COG3386	PFAM SMP-30 Gluconolaconase
I6J39_RS13915	COG0768	penicillin binding
I6J39_RS14015	COG1196	nuclear chromosome segregation
I6J39_RS14015	COG0739	heme binding
I6J39_RS14015	COG0741	lytic transglycosylase activity
I6J39_RS14035	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
I6J39_RS14045	COG0183	Belongs to the thiolase family
I6J39_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS14065	COG2770	Histidine kinase
I6J39_RS14065	COG2208	phosphoserine phosphatase activity
I6J39_RS14085	COG1309	transcriptional regulator
I6J39_RS14095	COG1301	dicarboxylic acid transport
I6J39_RS14105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J39_RS14115	COG0163	prenyltransferase activity
I6J39_RS14130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J39_RS14140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J39_RS14145	COG1333	cytochrome c biogenesis protein
I6J39_RS14150	COG0785	Cytochrome C biogenesis protein
I6J39_RS14155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J39_RS14165	COG0406	alpha-ribazole phosphatase activity
I6J39_RS14170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J39_RS14200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J39_RS14205	COG1690	Belongs to the RtcB family
I6J39_RS14230	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6J39_RS14235	COG0018	arginyl-trna synthetase
I6J39_RS14275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J39_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS14325	COG0515	serine threonine protein kinase
I6J39_RS14365	COG2267	carboxylic ester hydrolase activity
I6J39_RS14405	COG0671	phosphoesterase, PA-phosphatase related
I6J39_RS14420	COG0667	Aldo Keto reductase
I6J39_RS14425	COG1309	transcriptional regulator
I6J39_RS14455	COG2252	PERMEase
I6J39_RS14465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J39_RS14485	COG2814	Major facilitator Superfamily
I6J39_RS14495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J39_RS14500	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J39_RS14510	COG1278	Cold shock
I6J39_RS14535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS14540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS14545	COG1120	ATPase activity
I6J39_RS14550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J39_RS14600	COG1061	Type III restriction enzyme res subunit
I6J39_RS14610	COG1120	ATPase activity
I6J39_RS14640	COG3973	AAA domain
I6J39_RS14660	COG1984	allophanate hydrolase subunit 2
I6J39_RS14670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J39_RS14680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J39_RS14685	COG0640	Transcriptional regulator
I6J39_RS14690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J39_RS14710	COG1737	Transcriptional regulator
I6J39_RS14715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J39_RS14740	COG4257	antibiotic catabolic process
I6J39_RS14760	COG2204	response regulator
I6J39_RS14765	COG4251	negative regulation of phosphorylation
I6J39_RS14805	COG1175	transmembrane transport
I6J39_RS14810	COG0395	ABC-type sugar transport system, permease component
I6J39_RS14830	COG2318	DinB family
I6J39_RS14845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J39_RS14850	COG0546	phosphoglycolate phosphatase activity
I6J39_RS14910	COG1595	DNA-templated transcription, initiation
I6J39_RS14915	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J39_RS14915	COG2319	Wd-40 repeat
I6J39_RS14930	COG1132	(ABC) transporter
I6J39_RS14980	COG0463	Glycosyl transferase, family 2
I6J39_RS14995	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6J39_RS15020	COG2197	response regulator
I6J39_RS15060	COG0577	efflux transmembrane transporter activity
I6J39_RS15060	COG1136	(ABC) transporter
I6J39_RS15070	COG2197	response regulator
I6J39_RS15115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J39_RS15120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J39_RS15125	COG1754	DNA topoisomerase type I activity
I6J39_RS15125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J39_RS15135	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J39_RS15145	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J39_RS15155	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J39_RS15160	COG1111	helicase
I6J39_RS15160	COG1205	dead DEAH box helicase
I6J39_RS15220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J39_RS15225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J39_RS15235	COG2267	carboxylic ester hydrolase activity
I6J39_RS15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J39_RS15270	COG0251	oxidation-reduction process
I6J39_RS15285	COG0003	Pfam Anion-transporting ATPase
I6J39_RS15295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J39_RS15300	COG1610	YqeY-like protein
I6J39_RS15305	COG1408	metallophosphoesterase
I6J39_RS15320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J39_RS15325	COG2755	lipolytic protein G-D-S-L family
I6J39_RS15335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J39_RS15355	COG1595	DNA-templated transcription, initiation
I6J39_RS15385	COG0702	epimerase
I6J39_RS15395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J39_RS15400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J39_RS15415	COG1802	Transcriptional regulator
I6J39_RS15420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J39_RS15425	COG0693	protein deglycase activity
I6J39_RS15435	COG2124	cytochrome p450
I6J39_RS15445	COG0738	Major facilitator superfamily
I6J39_RS15450	COG3226	Transcriptional regulator
I6J39_RS15455	COG0667	Aldo Keto reductase
I6J39_RS15480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS15490	COG0662	Cupin 2, conserved barrel domain protein
I6J39_RS15495	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS15550	COG0590	tRNA wobble adenosine to inosine editing
I6J39_RS15560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J39_RS15590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J39_RS15610	COG2124	cytochrome p450
I6J39_RS15615	COG2197	response regulator
I6J39_RS15620	COG4585	Histidine kinase
I6J39_RS15625	COG0702	epimerase
I6J39_RS15635	COG3844	kynureninase activity
I6J39_RS15650	COG0477	Major facilitator Superfamily
I6J39_RS15655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J39_RS15660	COG0191	fructose-bisphosphate aldolase activity
I6J39_RS15665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J39_RS15680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6J39_RS15705	COG0542	response to heat
I6J39_RS15750	COG0789	Transcriptional regulator
I6J39_RS15755	COG0484	heat shock protein binding
I6J39_RS15760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J39_RS15765	COG0443	Heat shock 70 kDa protein
I6J39_RS15770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J39_RS15775	COG2181	nitrate reductase activity
I6J39_RS15775	COG0247	lactate metabolic process
I6J39_RS15795	COG0717	Belongs to the dCTP deaminase family
I6J39_RS15835	COG3209	COG3209 Rhs family protein
I6J39_RS15855	COG1309	transcriptional regulator
I6J39_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS15865	COG1278	Cold shock
I6J39_RS15935	COG2205	protein histidine kinase activity
I6J39_RS15940	COG0745	RESPONSE REGULATOR receiver
I6J39_RS16005	COG2409	Drug exporters of the RND superfamily
I6J39_RS16015	COG0513	Belongs to the DEAD box helicase family
I6J39_RS16020	COG1278	Cold shock
I6J39_RS16070	COG0450	alkyl hydroperoxide reductase
I6J39_RS16080	COG2268	Band 7 protein
I6J39_RS16130	COG0490	domain, Protein
I6J39_RS16135	COG0475	glutathione-regulated potassium exporter activity
I6J39_RS16140	COG0181	hydroxymethylbilane synthase activity
I6J39_RS16165	COG2255	four-way junction helicase activity
I6J39_RS16175	COG0180	Tryptophanyl-tRNA synthetase
I6J39_RS16180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS16215	COG0431	NADPH-dependent FMN reductase
I6J39_RS16240	COG2304	oxidoreductase activity
I6J39_RS16245	COG2205	protein histidine kinase activity
I6J39_RS16250	COG0745	RESPONSE REGULATOR receiver
I6J39_RS16255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J39_RS16270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J39_RS16285	COG1741	Belongs to the pirin family
I6J39_RS16295	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS16305	COG1362	aminopeptidase activity
I6J39_RS16315	COG3903	Transcriptional regulator
I6J39_RS16315	COG3629	intracellular signal transduction
I6J39_RS16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J39_RS16350	COG2271	Major facilitator Superfamily
I6J39_RS16355	COG1802	Transcriptional regulator
I6J39_RS16365	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J39_RS16370	COG0022	dehydrogenase e1 component
I6J39_RS16395	COG0515	serine threonine protein kinase
I6J39_RS16400	COG0515	serine threonine protein kinase
I6J39_RS16415	COG1136	(ABC) transporter
I6J39_RS16415	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J39_RS16440	COG0303	'Molybdopterin
I6J39_RS16465	COG1522	sequence-specific DNA binding
I6J39_RS16470	COG1309	transcriptional regulator
I6J39_RS16495	COG3396	Phenylacetate-CoA oxygenase
I6J39_RS16500	COG3460	Phenylacetate-CoA oxygenase
I6J39_RS16505	COG3396	Phenylacetate-CoA oxygenase
I6J39_RS16510	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J39_RS16515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J39_RS16550	COG1716	ATPase activity
I6J39_RS16555	COG1716	ATPase activity
I6J39_RS16570	COG0768	penicillin binding
I6J39_RS16575	COG0515	serine threonine protein kinase
I6J39_RS16580	COG3764	Sortase (surface protein transpeptidase)
I6J39_RS16585	COG3764	Sortase (surface protein transpeptidase)
I6J39_RS16600	COG3764	Sortase (surface protein transpeptidase)
I6J39_RS16640	COG0515	serine threonine protein kinase
I6J39_RS16670	COG0582	viral genome integration into host DNA
I6J39_RS16675	COG0582	viral genome integration into host DNA
I6J39_RS17105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J39_RS17115	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J39_RS17120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J39_RS17125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J39_RS17130	COG0592	DNA-directed DNA polymerase activity
I6J39_RS17145	COG0594	ribonuclease P activity
I6J39_RS17150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J39_RS17155	COG0706	membrane insertase activity
I6J39_RS17165	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J39_RS17170	COG1192	Involved in chromosome partitioning
I6J39_RS17185	COG3118	belongs to the thioredoxin family
I6J39_RS17190	COG0492	ferredoxin-NADP+ reductase activity
I6J39_RS17200	COG1595	DNA-templated transcription, initiation
I6J39_RS17205	COG0515	serine threonine protein kinase
I6J39_RS17205	COG2815	serine threonine protein kinase
I6J39_RS17220	COG0617	tRNA 3'-terminal CCA addition
I6J39_RS17240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J39_RS17265	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J39_RS17270	COG0629	single-stranded DNA binding
I6J39_RS17275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J39_RS17280	COG0359	binds to the 23S rRNA
I6J39_RS17290	COG0305	Participates in initiation and elongation during chromosome replication
I6J39_RS17315	COG2814	Major facilitator Superfamily
I6J39_RS17330	COG0626	cystathionine gamma-synthase activity
I6J39_RS17335	COG1950	PFAM Membrane protein of
I6J39_RS17340	COG0662	Cupin 2, conserved barrel domain protein
I6J39_RS17365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J39_RS17375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J39_RS17380	COG1609	Transcriptional regulator
I6J39_RS17385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J39_RS17390	COG1271	oxidase subunit
I6J39_RS17395	COG1294	oxidase, subunit
I6J39_RS17400	COG4988	ABC transporter
I6J39_RS17410	COG0561	phosphatase activity
I6J39_RS17420	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J39_RS17425	COG0789	Transcriptional regulator
I6J39_RS17440	COG1131	(ABC) transporter
I6J39_RS17465	COG0561	phosphatase activity
I6J39_RS17470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J39_RS17480	COG2837	iron assimilation
I6J39_RS17485	COG2372	response to copper ion
I6J39_RS17495	COG1999	signal sequence binding
I6J39_RS17515	COG0006	proline dipeptidase activity
I6J39_RS17530	COG0653	protein targeting
I6J39_RS17545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J39_RS17570	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS17595	COG1595	DNA-templated transcription, initiation
I6J39_RS17600	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS17635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J39_RS17660	COG0494	nUDIX hydrolase
I6J39_RS17680	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J39_RS17690	COG1252	NADH dehydrogenase
I6J39_RS17695	COG1595	DNA-templated transcription, initiation
I6J39_RS17715	COG0745	RESPONSE REGULATOR receiver
I6J39_RS17730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J39_RS17740	COG0477	Major facilitator Superfamily
I6J39_RS17755	COG3467	pyridoxamine 5'-phosphate
I6J39_RS17760	COG2353	YceI-like domain
I6J39_RS17785	COG1191	sigma factor activity
I6J39_RS17790	COG1191	sigma factor activity
I6J39_RS17830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J39_RS17845	COG2234	aminopeptidase activity
I6J39_RS17880	COG0464	growth
I6J39_RS17960	COG4941	Belongs to the sigma-70 factor family
I6J39_RS18010	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J39_RS18130	COG0492	ferredoxin-NADP+ reductase activity
I6J39_RS18155	COG0151	Belongs to the GarS family
I6J39_RS18170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J39_RS18180	COG2197	response regulator
I6J39_RS18195	COG1131	(ABC) transporter
I6J39_RS18215	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J39_RS18220	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J39_RS18225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J39_RS18235	COG1196	nuclear chromosome segregation
I6J39_RS18235	COG0741	lytic transglycosylase activity
I6J39_RS18235	COG0739	heme binding
I6J39_RS18250	COG3119	arylsulfatase activity
I6J39_RS18260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J39_RS18270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J39_RS18290	COG1643	Atp-dependent helicase
I6J39_RS18300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J39_RS18300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J39_RS18305	COG0785	Cytochrome C biogenesis protein
I6J39_RS18340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J39_RS18350	COG0513	Belongs to the DEAD box helicase family
I6J39_RS18360	COG0596	Alpha beta hydrolase
I6J39_RS18365	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J39_RS18375	COG0596	Alpha beta hydrolase
I6J39_RS18385	COG1191	sigma factor activity
I6J39_RS18400	COG1937	Protein conserved in bacteria
I6J39_RS18415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J39_RS18415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J39_RS18420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J39_RS18425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J39_RS18445	COG1196	nuclear chromosome segregation
I6J39_RS18445	COG0741	lytic transglycosylase activity
I6J39_RS18445	COG0739	heme binding
I6J39_RS18460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J39_RS18465	COG0579	oxidoreductase
I6J39_RS18490	COG1252	NADH dehydrogenase
I6J39_RS18505	COG1846	Transcriptional regulator
I6J39_RS18525	COG2197	response regulator
I6J39_RS18530	COG4585	Histidine kinase
I6J39_RS18610	COG0741	lytic transglycosylase activity
I6J39_RS18610	COG0739	heme binding
I6J39_RS18610	COG1196	nuclear chromosome segregation
I6J39_RS18615	COG0671	phosphoesterase, PA-phosphatase related
I6J39_RS18635	COG1937	Protein conserved in bacteria
I6J39_RS18645	COG0306	phosphate transporter
I6J39_RS18665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J39_RS18670	COG0406	alpha-ribazole phosphatase activity
I6J39_RS18670	COG0494	nUDIX hydrolase
I6J39_RS18690	COG1725	Transcriptional regulator
I6J39_RS18700	COG0456	acetyltransferase
I6J39_RS18710	COG0737	Belongs to the 5'-nucleotidase family
I6J39_RS18715	COG4106	trans-aconitate 2-methyltransferase activity
I6J39_RS18740	COG0154	amidase activity
I6J39_RS18755	COG4977	sequence-specific DNA binding
I6J39_RS18770	COG0739	heme binding
I6J39_RS18805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J39_RS18810	COG1609	Transcriptional regulator
I6J39_RS18815	COG0745	RESPONSE REGULATOR receiver
I6J39_RS18840	COG2897	thiosulfate sulfurtransferase activity
I6J39_RS18860	COG3485	protocatechuate 3,4-dioxygenase
I6J39_RS18865	COG0735	belongs to the Fur family
I6J39_RS18875	COG1490	D-aminoacyl-tRNA deacylase activity
I6J39_RS18890	COG4552	Acetyltransferase involved in intracellular survival and related
I6J39_RS18930	COG4942	peptidase
I6J39_RS18995	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS19050	COG0640	Transcriptional regulator
I6J39_RS19055	COG0798	PFAM Bile acid sodium symporter
I6J39_RS19060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J39_RS19070	COG0588	phosphoglycerate mutase activity
I6J39_RS19090	COG5002	protein histidine kinase activity
I6J39_RS19105	COG1329	Transcriptional regulator
I6J39_RS19110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J39_RS19115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J39_RS19130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS19140	COG3467	pyridoxamine 5'-phosphate
I6J39_RS19145	COG0215	cysteine-tRNA ligase activity
I6J39_RS19170	COG3842	ATPase activity
I6J39_RS19230	COG0745	RESPONSE REGULATOR receiver
I6J39_RS19275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J39_RS19295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J39_RS19315	COG2197	response regulator
I6J39_RS19350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J39_RS19375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J39_RS19385	COG1653	transport
I6J39_RS19410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J39_RS19410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J39_RS19445	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS19475	COG0076	glutamate decarboxylase activity
I6J39_RS19480	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J39_RS19490	COG0393	Putative heavy-metal-binding
I6J39_RS19495	COG0586	Pfam SNARE associated Golgi protein
I6J39_RS19505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J39_RS19510	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J39_RS19520	COG0037	tRNA processing
I6J39_RS19535	COG0302	gtp cyclohydrolase
I6J39_RS19550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J39_RS19565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J39_RS19565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J39_RS19575	COG1125	glycine betaine transport
I6J39_RS19575	COG0517	IMP dehydrogenase activity
I6J39_RS19580	COG1174	glycine betaine transport
I6J39_RS19585	COG1174	glycine betaine transport
I6J39_RS19600	COG0649	NAD binding
I6J39_RS19615	COG2197	response regulator
I6J39_RS19620	COG1660	Displays ATPase and GTPase activities
I6J39_RS19645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J39_RS19650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J39_RS19660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J39_RS19680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J39_RS19710	COG0739	heme binding
I6J39_RS19715	COG2205	protein histidine kinase activity
I6J39_RS19720	COG0745	RESPONSE REGULATOR receiver
I6J39_RS19730	COG1595	DNA-templated transcription, initiation
I6J39_RS19735	COG1194	a g-specific adenine glycosylase
I6J39_RS19745	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6J39_RS19765	COG0248	Ppx GppA phosphatase
I6J39_RS19770	COG1082	Xylose isomerase domain protein TIM barrel
I6J39_RS19780	COG0129	dihydroxy-acid dehydratase activity
I6J39_RS19785	COG0515	serine threonine protein kinase
I6J39_RS19785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J39_RS19790	COG4991	sh3 domain protein
I6J39_RS19800	COG1129	ABC transporter
I6J39_RS19800	COG0842	Transport permease protein
I6J39_RS19810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J39_RS19830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS19890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J39_RS19895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J39_RS19900	COG0181	hydroxymethylbilane synthase activity
I6J39_RS19905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J39_RS19905	COG1648	precorrin-2 dehydrogenase activity
I6J39_RS19910	COG0113	porphobilinogen synthase activity
I6J39_RS19945	COG2318	DinB family
I6J39_RS19980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J39_RS20005	COG2161	toxin-antitoxin pair type II binding
I6J39_RS20045	COG0577	efflux transmembrane transporter activity
I6J39_RS20045	COG1136	(ABC) transporter
I6J39_RS20065	COG0745	RESPONSE REGULATOR receiver
I6J39_RS20070	COG2205	protein histidine kinase activity
I6J39_RS20090	COG1309	transcriptional regulator
I6J39_RS20150	COG1335	isochorismatase
I6J39_RS20165	COG2318	DinB family
I6J39_RS20175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J39_RS20205	COG2205	protein histidine kinase activity
I6J39_RS20210	COG0277	FAD linked oxidase domain protein
I6J39_RS20210	COG0247	lactate metabolic process
I6J39_RS20215	COG0583	DNA-binding transcription factor activity
I6J39_RS20220	COG5006	permease, DMT superfamily
I6J39_RS20225	COG4221	oxidoreductase activity
I6J39_RS20230	COG1309	transcriptional regulator
I6J39_RS20255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J39_RS20270	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS20275	COG1024	Enoyl-CoA hydratase
I6J39_RS20345	COG1396	sequence-specific DNA binding
I6J39_RS20365	COG0259	pyridoxamine-phosphate oxidase activity
I6J39_RS20375	COG4821	SIS domain
I6J39_RS20430	COG0604	alcohol dehydrogenase
I6J39_RS20460	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS20465	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS20485	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS20525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J39_RS20530	COG1024	Enoyl-CoA hydratase
I6J39_RS20555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J39_RS20565	COG2072	flavoprotein involved in K transport
I6J39_RS20580	COG2124	cytochrome p450
I6J39_RS20595	COG0501	Belongs to the peptidase M48B family
I6J39_RS20620	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS20630	COG1309	transcriptional regulator
I6J39_RS20655	COG1024	Enoyl-CoA hydratase
I6J39_RS20670	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS20700	COG0789	Transcriptional regulator
I6J39_RS20705	COG1278	Cold shock
I6J39_RS20710	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J39_RS20720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J39_RS20745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J39_RS20750	COG4521	taurine ABC transporter
I6J39_RS20760	COG2175	clavaminate synthase activity
I6J39_RS20765	COG2226	methyltransferase
I6J39_RS20830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS20835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS20840	COG0649	NAD binding
I6J39_RS20850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J39_RS20855	COG1034	ATP synthesis coupled electron transport
I6J39_RS20860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J39_RS20865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS20870	COG0839	Belongs to the complex I subunit 6 family
I6J39_RS20875	COG0713	ATP synthesis coupled electron transport
I6J39_RS20880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J39_RS20890	COG1007	ATP synthesis coupled electron transport
I6J39_RS20895	COG0514	ATP-dependent DNA helicase (RecQ)
I6J39_RS20930	COG3104	oligopeptide transport
I6J39_RS20935	COG0142	geranyltranstransferase activity
I6J39_RS20960	COG0515	serine threonine protein kinase
I6J39_RS20960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J39_RS20975	COG0789	Transcriptional regulator
I6J39_RS20980	COG4221	oxidoreductase activity
I6J39_RS21000	COG0561	phosphatase activity
I6J39_RS21015	COG0667	Aldo Keto reductase
I6J39_RS21105	COG0702	epimerase
I6J39_RS21110	COG1733	regulation of RNA biosynthetic process
I6J39_RS21115	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J39_RS21120	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J39_RS21120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J39_RS21135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS21145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS21150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J39_RS21155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J39_RS21160	COG0839	Belongs to the complex I subunit 6 family
I6J39_RS21165	COG0713	ATP synthesis coupled electron transport
I6J39_RS21170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J39_RS21180	COG1007	ATP synthesis coupled electron transport
I6J39_RS21185	COG1970	mechanosensitive ion channel activity
I6J39_RS21190	COG0501	Belongs to the peptidase M48B family
I6J39_RS21195	COG3304	Inner membrane component domain
I6J39_RS21210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J39_RS21215	COG1666	GTP binding
I6J39_RS21225	COG0702	epimerase
I6J39_RS21245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J39_RS21250	COG2030	dehydratase
I6J39_RS21270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J39_RS21275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J39_RS21280	COG0436	Aminotransferase
I6J39_RS21300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J39_RS21305	COG0081	regulation of translation
I6J39_RS21315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J39_RS21320	COG0222	ribosome binding
I6J39_RS21325	COG0085	RNA polymerase activity
I6J39_RS21330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J39_RS21335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J39_RS21415	COG0739	heme binding
I6J39_RS21415	COG1196	nuclear chromosome segregation
I6J39_RS21415	COG0741	lytic transglycosylase activity
I6J39_RS21430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J39_RS21435	COG0049	tRNA binding
I6J39_RS21440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J39_RS21445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J39_RS21450	COG4585	Histidine kinase
I6J39_RS21455	COG2197	response regulator
I6J39_RS21470	COG0051	transcription antitermination factor activity, RNA binding
I6J39_RS21475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J39_RS21480	COG0088	Forms part of the polypeptide exit tunnel
I6J39_RS21485	COG0089	rRNA binding
I6J39_RS21490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J39_RS21495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J39_RS21500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J39_RS21505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J39_RS21510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J39_RS21515	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J39_RS21520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J39_RS21525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J39_RS21530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J39_RS21535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J39_RS21540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J39_RS21545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J39_RS21550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J39_RS21555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J39_RS21560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J39_RS21565	COG1841	ribosomal large subunit assembly
I6J39_RS21570	COG0200	Binds to the 23S rRNA
I6J39_RS21580	COG0563	adenylate kinase activity
I6J39_RS21590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J39_RS21595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J39_RS21600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J39_RS21605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J39_RS21610	COG0202	RNA polymerase activity
I6J39_RS21615	COG0203	ribosomal protein L17
I6J39_RS21620	COG0101	tRNA pseudouridine synthase activity
I6J39_RS21630	COG0488	(ABC) transporter
I6J39_RS21635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J39_RS21640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J39_RS21645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J39_RS21655	COG1072	(Pantothenic acid kinase))
I6J39_RS21735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J39_RS21740	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J39_RS21750	COG3189	MarR family transcriptional regulator
I6J39_RS21765	COG0802	atpase or kinase
I6J39_RS21790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J39_RS21825	COG0726	polysaccharide deacetylase
I6J39_RS21835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J39_RS21850	COG2132	Multicopper oxidase
I6J39_RS21865	COG0583	DNA-binding transcription factor activity
I6J39_RS21880	COG1595	DNA-templated transcription, initiation
I6J39_RS21890	COG0516	GMP reductase activity
I6J39_RS21905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J39_RS21920	COG0515	serine threonine protein kinase
I6J39_RS21925	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS21945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J39_RS21945	COG0519	Catalyzes the synthesis of GMP from XMP
I6J39_RS21955	COG4106	trans-aconitate 2-methyltransferase activity
I6J39_RS21985	COG2197	response regulator
I6J39_RS22010	COG0739	heme binding
I6J39_RS22020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J39_RS22040	COG0714	Associated with various cellular activities
I6J39_RS22050	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J39_RS22055	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J39_RS22085	COG0138	bifunctional purine biosynthesis protein purh
I6J39_RS22100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J39_RS22115	COG0039	L-malate dehydrogenase activity
I6J39_RS22135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J39_RS22140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J39_RS22150	COG0754	glutathionylspermidine amidase activity
I6J39_RS22155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J39_RS22160	COG0180	Tryptophanyl-tRNA synthetase
I6J39_RS22180	COG1295	ribonuclease BN
I6J39_RS22195	COG1408	metallophosphoesterase
I6J39_RS22230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J39_RS22235	COG1053	succinate dehydrogenase
I6J39_RS22245	COG2009	succinate dehydrogenase
I6J39_RS22295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J39_RS22300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J39_RS22305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J39_RS22345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J39_RS22350	COG1595	DNA-templated transcription, initiation
I6J39_RS22395	COG1216	Glycosyl transferase, family 2
I6J39_RS22405	COG1083	cytidylyl-transferase
I6J39_RS22410	COG2089	acid synthase
I6J39_RS22435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J39_RS22435	COG1473	amidohydrolase
I6J39_RS22440	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J39_RS22445	COG3845	ABC transporter
I6J39_RS22450	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J39_RS22455	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J39_RS22475	COG1404	Belongs to the peptidase S8 family
I6J39_RS22495	COG2814	Major facilitator Superfamily
I6J39_RS22500	COG0583	DNA-binding transcription factor activity
I6J39_RS22520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J39_RS22545	COG2205	protein histidine kinase activity
I6J39_RS22550	COG0745	RESPONSE REGULATOR receiver
I6J39_RS22555	COG1595	DNA-templated transcription, initiation
I6J39_RS22570	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS22575	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS22590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J39_RS22620	COG4770	biotin carboxylase activity
I6J39_RS22630	COG0424	maF-like protein
I6J39_RS22640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J39_RS22655	COG1024	Enoyl-CoA hydratase
I6J39_RS22680	COG1376	ErfK ybiS ycfS ynhG family protein
I6J39_RS22700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J39_RS22710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J39_RS22715	COG0583	DNA-binding transcription factor activity
I6J39_RS22755	COG1595	DNA-templated transcription, initiation
I6J39_RS22760	COG0745	RESPONSE REGULATOR receiver
I6J39_RS22765	COG5002	protein histidine kinase activity
I6J39_RS22765	COG0784	Response regulator, receiver
I6J39_RS22765	COG2198	Histidine kinase
I6J39_RS22775	COG2172	sigma factor antagonist activity
I6J39_RS22780	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J39_RS22785	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J39_RS22795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J39_RS22810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J39_RS22820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J39_RS22845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J39_RS22865	COG3321	synthase
I6J39_RS22865	COG3321	synthase
I6J39_RS22865	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS22865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS22865	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS22865	COG0300	oxidoreductase activity
I6J39_RS22865	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS22865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS22865	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS22865	COG0300	oxidoreductase activity
I6J39_RS22870	COG3251	PFAM MbtH domain protein
I6J39_RS22900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J39_RS22905	COG2175	clavaminate synthase activity
I6J39_RS22910	COG2197	response regulator
I6J39_RS22915	COG0577	efflux transmembrane transporter activity
I6J39_RS22915	COG1136	(ABC) transporter
I6J39_RS22925	COG4585	Histidine kinase
I6J39_RS22955	COG0154	amidase activity
I6J39_RS22980	COG1331	Highly conserved protein containing a thioredoxin domain
I6J39_RS22990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J39_RS23000	COG0436	Aminotransferase
I6J39_RS23020	COG1733	regulation of RNA biosynthetic process
I6J39_RS23040	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J39_RS23055	COG1414	Transcriptional regulator
I6J39_RS23060	COG0251	oxidation-reduction process
I6J39_RS23065	COG2610	gluconate transmembrane transporter activity
I6J39_RS23090	COG2894	cell division
I6J39_RS23125	COG2197	response regulator
I6J39_RS23145	COG2885	chlorophyll binding
I6J39_RS23210	COG2226	methyltransferase
I6J39_RS23220	COG0667	Aldo Keto reductase
I6J39_RS23225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J39_RS23230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J39_RS23245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J39_RS23250	COG0450	alkyl hydroperoxide reductase
I6J39_RS23265	COG1136	(ABC) transporter
I6J39_RS23285	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J39_RS23285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J39_RS23300	COG0114	fumarate hydratase activity
I6J39_RS23310	COG1362	aminopeptidase activity
I6J39_RS23340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J39_RS23340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J39_RS23365	COG0778	Nitroreductase
I6J39_RS23370	COG1722	exodeoxyribonuclease VII activity
I6J39_RS23375	COG1570	exodeoxyribonuclease VII activity
I6J39_RS23385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J39_RS23400	COG0012	GTP binding
I6J39_RS23410	COG0477	Major facilitator Superfamily
I6J39_RS23420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J39_RS23550	COG0789	Transcriptional regulator
I6J39_RS23605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J39_RS23620	COG2409	Drug exporters of the RND superfamily
I6J39_RS23625	COG4585	Histidine kinase
I6J39_RS23630	COG2197	response regulator
I6J39_RS23635	COG0154	amidase activity
I6J39_RS23650	COG1217	gtp-binding protein TYPA
I6J39_RS23660	COG0601	transmembrane transport
I6J39_RS23665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS23675	COG4608	Belongs to the ABC transporter superfamily
I6J39_RS23680	COG4166	transmembrane transport
I6J39_RS23685	COG0601	transmembrane transport
I6J39_RS23690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS23700	COG4608	Belongs to the ABC transporter superfamily
I6J39_RS23715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J39_RS23735	COG0110	maltose O-acetyltransferase activity
I6J39_RS23750	COG0515	serine threonine protein kinase
I6J39_RS23765	COG1132	(ABC) transporter
I6J39_RS23770	COG2197	response regulator
I6J39_RS23775	COG2912	Transglutaminase-like superfamily
I6J39_RS23805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J39_RS23810	COG1611	Belongs to the LOG family
I6J39_RS23815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J39_RS23825	COG0519	Catalyzes the synthesis of GMP from XMP
I6J39_RS23830	COG1024	Enoyl-CoA hydratase
I6J39_RS23845	COG1595	DNA-templated transcription, initiation
I6J39_RS23855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J39_RS23860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J39_RS23895	COG0598	Magnesium transport protein CorA
I6J39_RS23905	COG2814	Major facilitator Superfamily
I6J39_RS23920	COG2095	MarC family integral membrane protein
I6J39_RS23930	COG1432	Conserved Protein
I6J39_RS23940	COG0513	Belongs to the DEAD box helicase family
I6J39_RS23980	COG0747	negative chemotaxis
I6J39_RS23990	COG0601	transmembrane transport
I6J39_RS23995	COG4172	Belongs to the ABC transporter superfamily
I6J39_RS24040	COG0210	DNA helicase
I6J39_RS24140	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J39_RS24150	COG1615	UPF0182 protein
I6J39_RS24175	COG0753	catalase activity
I6J39_RS24185	COG0483	inositol monophosphate 1-phosphatase activity
I6J39_RS24195	COG2076	Multidrug Resistance protein
I6J39_RS24205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J39_RS24215	COG2135	peptidase activity
I6J39_RS24225	COG1595	DNA-templated transcription, initiation
I6J39_RS24230	COG5662	AntiSigma factor
I6J39_RS24240	COG0242	peptide deformylase activity
I6J39_RS24275	COG1966	Carbon starvation protein
I6J39_RS24280	COG2188	Transcriptional regulator
I6J39_RS24285	COG2182	Extracellular solute-binding protein
I6J39_RS24290	COG1175	transmembrane transport
I6J39_RS24295	COG0395	ABC-type sugar transport system, permease component
I6J39_RS24300	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J39_RS24305	COG0363	glucosamine-6-phosphate deaminase activity
I6J39_RS24310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J39_RS24325	COG1597	lipid kinase activity
I6J39_RS24365	COG1959	2 iron, 2 sulfur cluster binding
I6J39_RS24370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J39_RS24375	COG0142	geranyltranstransferase activity
I6J39_RS24440	COG2197	response regulator
I6J39_RS24445	COG4585	Histidine kinase
I6J39_RS24465	COG1695	Transcriptional regulator
I6J39_RS24500	COG0242	peptide deformylase activity
I6J39_RS24525	COG4106	trans-aconitate 2-methyltransferase activity
I6J39_RS24530	COG1595	DNA-templated transcription, initiation
I6J39_RS24540	COG1126	abc transporter atp-binding protein
I6J39_RS24545	COG0765	amino acid transport
I6J39_RS24550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS24555	COG0281	malic enzyme
I6J39_RS24560	COG0604	alcohol dehydrogenase
I6J39_RS24580	COG0542	response to heat
I6J39_RS24605	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J39_RS24605	COG0567	Dehydrogenase, E1 component
I6J39_RS24610	COG2205	protein histidine kinase activity
I6J39_RS24615	COG0745	RESPONSE REGULATOR receiver
I6J39_RS24625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J39_RS24630	COG0726	polysaccharide deacetylase
I6J39_RS24690	COG1309	transcriptional regulator
I6J39_RS24740	COG2205	protein histidine kinase activity
I6J39_RS24760	COG1793	dna ligase
I6J39_RS24760	COG3285	dna ligase
I6J39_RS24765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J39_RS24770	COG0515	serine threonine protein kinase
I6J39_RS24780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J39_RS24805	COG0018	arginyl-trna synthetase
I6J39_RS24810	COG0019	diaminopimelate decarboxylase activity
I6J39_RS24815	COG0460	homoserine dehydrogenase
I6J39_RS24820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J39_RS24825	COG0083	homoserine kinase activity
I6J39_RS24835	COG1316	TRANSCRIPTIONal
I6J39_RS24840	COG0254	rRNA binding
I6J39_RS24845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J39_RS24850	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J39_RS24860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J39_RS24865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J39_RS24885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J39_RS24890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J39_RS24895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J39_RS24900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J39_RS24905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J39_RS24910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J39_RS24915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J39_RS24930	COG2197	response regulator
I6J39_RS24935	COG4585	Histidine kinase
I6J39_RS24965	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS24980	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J39_RS25035	COG0183	Belongs to the thiolase family
I6J39_RS25050	COG0745	RESPONSE REGULATOR receiver
I6J39_RS25055	COG5000	phosphorelay sensor kinase activity
I6J39_RS25055	COG5002	protein histidine kinase activity
I6J39_RS25125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J39_RS25125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J39_RS25170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J39_RS25175	COG0857	belongs to the CobB CobQ family
I6J39_RS25175	COG0280	phosphate acetyltransferase
I6J39_RS25180	COG0205	6-phosphofructokinase activity
I6J39_RS25190	COG4565	transcriptional regulatory protein
I6J39_RS25195	COG3290	protein histidine kinase activity
I6J39_RS25200	COG1301	dicarboxylic acid transport
I6J39_RS25225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J39_RS25235	COG0366	Alpha amylase catalytic
I6J39_RS25240	COG0366	Alpha amylase catalytic
I6J39_RS25245	COG0058	SHG alpha-glucan phosphorylase activity
I6J39_RS25265	COG0387	Pfam Sodium calcium exchanger
I6J39_RS25285	COG1742	UPF0060 membrane protein
I6J39_RS25290	COG1132	(ABC) transporter
I6J39_RS25300	COG1131	(ABC) transporter
I6J39_RS25315	COG2197	response regulator
I6J39_RS25365	COG0515	serine threonine protein kinase
I6J39_RS25465	COG0823	Involved in the tonB-independent uptake of proteins
I6J39_RS25465	COG1506	peptidase
I6J39_RS25475	COG0464	growth
I6J39_RS25505	COG1760	l-serine dehydratase
I6J39_RS25510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J39_RS25515	COG0509	glycine decarboxylation via glycine cleavage system
I6J39_RS25520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J39_RS25540	COG0747	negative chemotaxis
I6J39_RS25545	COG0601	transmembrane transport
I6J39_RS25550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS25560	COG4608	Belongs to the ABC transporter superfamily
I6J39_RS25565	COG2860	membrane
I6J39_RS25575	COG2378	regulation of single-species biofilm formation
I6J39_RS25605	COG0482	sulfurtransferase activity
I6J39_RS25625	COG4221	oxidoreductase activity
I6J39_RS25635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J39_RS25645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J39_RS25650	COG0154	amidase activity
I6J39_RS25660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J39_RS25665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J39_RS25675	COG2409	Drug exporters of the RND superfamily
I6J39_RS25690	COG2197	response regulator
I6J39_RS25700	COG2133	pyrroloquinoline quinone binding
I6J39_RS25705	COG0667	Aldo Keto reductase
I6J39_RS25715	COG5001	Diguanylate cyclase
I6J39_RS25715	COG3300	MHYT domain
I6J39_RS25725	COG0440	acetolactate synthase activity
I6J39_RS25730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J39_RS25735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J39_RS25755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J39_RS25765	COG2508	Transcriptional regulator
I6J39_RS25770	COG0506	proline dehydrogenase activity
I6J39_RS25775	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS25780	COG0778	Nitroreductase
I6J39_RS25780	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J39_RS25795	COG0473	3-isopropylmalate dehydrogenase activity
I6J39_RS25800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J39_RS25810	COG2957	Belongs to the agmatine deiminase family
I6J39_RS25820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J39_RS25825	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J39_RS25835	COG0542	response to heat
I6J39_RS25860	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J39_RS25875	COG2207	Transcriptional regulator
I6J39_RS25875	COG3708	Transcriptional regulator
I6J39_RS25895	COG0492	ferredoxin-NADP+ reductase activity
I6J39_RS25940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS25945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS25950	COG1120	ATPase activity
I6J39_RS25955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J39_RS25960	COG2353	YceI-like domain
I6J39_RS25975	COG1470	cell adhesion involved in biofilm formation
I6J39_RS25975	COG0366	Alpha amylase catalytic
I6J39_RS25980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J39_RS26000	COG2018	Roadblock/LC7 domain
I6J39_RS26020	COG2018	Roadblock/LC7 domain
I6J39_RS26025	COG5002	protein histidine kinase activity
I6J39_RS26035	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J39_RS26040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J39_RS26085	COG1414	Transcriptional regulator
I6J39_RS26090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J39_RS26095	COG0066	3-isopropylmalate dehydratase activity
I6J39_RS26105	COG0776	regulation of translation
I6J39_RS26115	COG1920	GTP binding
I6J39_RS26125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J39_RS26130	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J39_RS26150	COG0351	phosphomethylpyrimidine kinase
I6J39_RS26155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J39_RS26160	COG1461	Dihydroxyacetone kinase
I6J39_RS26170	COG0742	ribosomal rna small subunit methyltransferase
I6J39_RS26175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J39_RS26190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J39_RS26195	COG0571	ribonuclease III activity
I6J39_RS26200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J39_RS26205	COG1733	regulation of RNA biosynthetic process
I6J39_RS26210	COG2340	Cysteine-rich secretory protein family
I6J39_RS26215	COG1254	Belongs to the acylphosphatase family
I6J39_RS26225	COG1196	nuclear chromosome segregation
I6J39_RS26230	COG0477	Major facilitator Superfamily
I6J39_RS26265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J39_RS26285	COG0228	four-way junction DNA binding
I6J39_RS26290	COG1837	Belongs to the UPF0109 family
I6J39_RS26295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J39_RS26300	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J39_RS26305	COG0335	large ribosomal subunit rRNA binding
I6J39_RS26320	COG0681	Belongs to the peptidase S26 family
I6J39_RS26330	COG1051	belongs to the nudix hydrolase family
I6J39_RS26340	COG0792	nuclease activity
I6J39_RS26385	COG1396	sequence-specific DNA binding
I6J39_RS26385	COG3800	Transcriptional regulator
I6J39_RS26445	COG1191	sigma factor activity
I6J39_RS26460	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J39_RS26465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J39_RS26470	COG0528	UMP kinase activity
I6J39_RS26475	COG0233	cytoplasmic translational termination
I6J39_RS26480	COG0575	Belongs to the CDS family
I6J39_RS26565	COG2226	methyltransferase
I6J39_RS26570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J39_RS26585	COG3842	ATPase activity
I6J39_RS26600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J39_RS26610	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS26635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J39_RS26675	COG1595	DNA-templated transcription, initiation
I6J39_RS26705	COG3842	ATPase activity
I6J39_RS26710	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J39_RS26715	COG1177	transmembrane transport
I6J39_RS26720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J39_RS26750	COG2508	Transcriptional regulator
I6J39_RS26760	COG2814	Major facilitator Superfamily
I6J39_RS26765	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS26775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J39_RS26780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J39_RS26785	COG0750	zinc metalloprotease
I6J39_RS26790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J39_RS26805	COG0442	prolyl-tRNA aminoacylation
I6J39_RS26825	COG0779	Required for maturation of 30S ribosomal subunits
I6J39_RS26840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J39_RS26850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J39_RS26855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J39_RS26890	COG4608	Belongs to the ABC transporter superfamily
I6J39_RS26900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS26905	COG0601	transmembrane transport
I6J39_RS26910	COG0747	negative chemotaxis
I6J39_RS26915	COG0455	bacterial-type flagellum organization
I6J39_RS26940	COG1404	Belongs to the peptidase S8 family
I6J39_RS26955	COG1404	Belongs to the peptidase S8 family
I6J39_RS26970	COG1674	ftsk spoiiie
I6J39_RS26980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J39_RS26985	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J39_RS26990	COG0612	Peptidase, M16
I6J39_RS26995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J39_RS27015	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J39_RS27020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J39_RS27025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J39_RS27055	COG2205	protein histidine kinase activity
I6J39_RS27055	COG3850	Histidine kinase
I6J39_RS27055	COG3437	response regulator, receiver
I6J39_RS27055	COG4999	Histidine kinase
I6J39_RS27065	COG1674	ftsk spoiiie
I6J39_RS27075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J39_RS27085	COG1058	Belongs to the CinA family
I6J39_RS27085	COG1546	Belongs to the CinA family
I6J39_RS27090	COG1396	sequence-specific DNA binding
I6J39_RS27095	COG0783	Belongs to the Dps family
I6J39_RS27105	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS27110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J39_RS27115	COG1201	RNA secondary structure unwinding
I6J39_RS27120	COG1917	Cupin 2, conserved barrel domain protein
I6J39_RS27120	COG2207	Transcriptional regulator
I6J39_RS27150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J39_RS27180	COG0765	amino acid transport
I6J39_RS27185	COG0765	amino acid transport
I6J39_RS27190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS27195	COG1126	abc transporter atp-binding protein
I6J39_RS27205	COG2205	protein histidine kinase activity
I6J39_RS27210	COG2358	TRAP transporter, solute receptor (TAXI family
I6J39_RS27215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J39_RS27230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J39_RS27240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J39_RS27245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J39_RS27255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J39_RS27295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J39_RS27300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J39_RS27305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J39_RS27335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J39_RS27370	COG2186	Transcriptional regulator
I6J39_RS27375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J39_RS27400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J39_RS27405	COG4565	transcriptional regulatory protein
I6J39_RS27410	COG3290	protein histidine kinase activity
I6J39_RS27415	COG0372	Belongs to the citrate synthase family
I6J39_RS27420	COG0372	Belongs to the citrate synthase family
I6J39_RS27430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J39_RS27435	COG0612	Peptidase, M16
I6J39_RS27450	COG1802	Transcriptional regulator
I6J39_RS27455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J39_RS27460	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J39_RS27460	COG1042	CoA-binding domain protein
I6J39_RS27460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J39_RS27475	COG1435	thymidine kinase activity
I6J39_RS27515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J39_RS27530	COG0745	RESPONSE REGULATOR receiver
I6J39_RS27535	COG2205	protein histidine kinase activity
I6J39_RS27560	COG0756	dUTP diphosphatase activity
I6J39_RS27570	COG1136	(ABC) transporter
I6J39_RS27570	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J39_RS27600	COG0569	domain protein
I6J39_RS27605	COG0531	amino acid
I6J39_RS27610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J39_RS27640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J39_RS27645	COG4552	Acetyltransferase involved in intracellular survival and related
I6J39_RS27665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J39_RS27710	COG2814	Major facilitator Superfamily
I6J39_RS27725	COG0596	Alpha beta hydrolase
I6J39_RS27735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J39_RS27745	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J39_RS27755	COG3938	Belongs to the proline racemase family
I6J39_RS27765	COG2423	ornithine cyclodeaminase activity
I6J39_RS27770	COG1802	Transcriptional regulator
I6J39_RS27775	COG0006	proline dipeptidase activity
I6J39_RS27785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS27790	COG0601	transmembrane transport
I6J39_RS27805	COG3291	Pkd domain containing protein
I6J39_RS27815	COG1280	lysine exporter protein (LysE YggA)
I6J39_RS27820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J39_RS27825	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J39_RS27855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS27860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS27870	COG0586	Pfam SNARE associated Golgi protein
I6J39_RS27875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J39_RS27880	COG1349	DNA-binding transcription factor activity
I6J39_RS27885	COG1799	cell septum assembly
I6J39_RS27905	COG2040	homocysteine
I6J39_RS27915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J39_RS27925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J39_RS27930	COG0531	amino acid
I6J39_RS27940	COG1024	Enoyl-CoA hydratase
I6J39_RS27980	COG2111	Na H antiporter
I6J39_RS27980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J39_RS27985	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J39_RS27990	COG0651	ATP synthesis coupled electron transport
I6J39_RS28005	COG1320	monovalent cation:proton antiporter activity
I6J39_RS28020	COG0297	glycogen (starch) synthase activity
I6J39_RS28025	COG0489	protein tyrosine kinase activity
I6J39_RS28060	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J39_RS28065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J39_RS28070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J39_RS28085	COG2197	response regulator
I6J39_RS28105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J39_RS28145	COG0477	Major facilitator Superfamily
I6J39_RS28150	COG3903	Transcriptional regulator
I6J39_RS28150	COG3629	intracellular signal transduction
I6J39_RS28165	COG0300	oxidoreductase activity
I6J39_RS28175	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS28200	COG0475	glutathione-regulated potassium exporter activity
I6J39_RS28220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS28235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J39_RS28265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J39_RS28270	COG0494	nUDIX hydrolase
I6J39_RS28290	COG0588	phosphoglycerate mutase activity
I6J39_RS28300	COG1653	transport
I6J39_RS28305	COG1175	transmembrane transport
I6J39_RS28310	COG0395	ABC-type sugar transport system, permease component
I6J39_RS28315	COG1940	carbohydrate kinase activity
I6J39_RS28320	COG4213	ABC transporter substrate-binding protein
I6J39_RS28330	COG4214	carbohydrate transport
I6J39_RS28335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J39_RS28340	COG0531	amino acid
I6J39_RS28365	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS28380	COG1024	Enoyl-CoA hydratase
I6J39_RS28380	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS28385	COG0183	Belongs to the thiolase family
I6J39_RS28410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J39_RS28425	COG0745	RESPONSE REGULATOR receiver
I6J39_RS28430	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J39_RS28440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J39_RS28445	COG3253	May function as heme-dependent peroxidase
I6J39_RS28460	COG3220	belongs to the UPF0276 family
I6J39_RS28475	COG4152	abc transporter atp-binding protein
I6J39_RS28495	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J39_RS28545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J39_RS28550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J39_RS28655	COG1063	alcohol dehydrogenase
I6J39_RS28660	COG0156	8-amino-7-oxononanoate synthase activity
I6J39_RS28665	COG0583	DNA-binding transcription factor activity
I6J39_RS28675	COG0346	lactoylglutathione lyase activity
I6J39_RS28680	COG1072	(Pantothenic acid kinase))
I6J39_RS28700	COG2723	6-phospho-beta-galactosidase activity
I6J39_RS28755	COG1175	transmembrane transport
I6J39_RS28775	COG1404	Belongs to the peptidase S8 family
I6J39_RS28795	COG1132	(ABC) transporter
I6J39_RS28800	COG1132	(ABC) transporter
I6J39_RS28805	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J39_RS28810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS28815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS28820	COG1120	ATPase activity
I6J39_RS28825	COG2226	methyltransferase
I6J39_RS28835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J39_RS28840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J39_RS28860	COG0529	Catalyzes the synthesis of activated sulfate
I6J39_RS28865	COG0175	sulfate reduction
I6J39_RS28900	COG3844	kynureninase activity
I6J39_RS28905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J39_RS28920	COG1917	Cupin 2, conserved barrel domain protein
I6J39_RS28945	COG0583	DNA-binding transcription factor activity
I6J39_RS28950	COG2814	Major facilitator Superfamily
I6J39_RS28970	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS28975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J39_RS28980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J39_RS28985	COG0583	DNA-binding transcription factor activity
I6J39_RS28990	COG0183	Belongs to the thiolase family
I6J39_RS29040	COG1162	GTPase activity
I6J39_RS29060	COG1404	Belongs to the peptidase S8 family
I6J39_RS29070	COG0028	Belongs to the TPP enzyme family
I6J39_RS29090	COG1802	Transcriptional regulator
I6J39_RS29115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J39_RS29120	COG2252	PERMEase
I6J39_RS29125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J39_RS29125	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J39_RS29150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS29180	COG0435	Glutathione S-transferase
I6J39_RS29195	COG2197	response regulator
I6J39_RS29200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J39_RS29205	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS29225	COG3960	tartronate-semialdehyde synthase activity
I6J39_RS29250	COG0753	catalase activity
I6J39_RS29255	COG2084	Dehydrogenase
I6J39_RS29260	COG3622	Belongs to the hyi family
I6J39_RS29265	COG2706	6-phosphogluconolactonase activity
I6J39_RS29285	COG2351	hydroxyisourate hydrolase activity
I6J39_RS29295	COG2233	PERMEase
I6J39_RS29305	COG2233	PERMEase
I6J39_RS29330	COG1288	antiporter activity
I6J39_RS29360	COG0242	peptide deformylase activity
I6J39_RS29365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J39_RS29380	COG2197	response regulator
I6J39_RS29400	COG1414	Transcriptional regulator
I6J39_RS29405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J39_RS29410	COG4266	Belongs to the allantoicase family
I6J39_RS29420	COG0656	L-ascorbic acid biosynthetic process
I6J39_RS29425	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS29445	COG2197	response regulator
I6J39_RS29460	COG0673	inositol 2-dehydrogenase activity
I6J39_RS29465	COG2188	Transcriptional regulator
I6J39_RS29480	COG1129	ABC transporter
I6J39_RS29485	COG1940	carbohydrate kinase activity
I6J39_RS29495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J39_RS29500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J39_RS29535	COG1126	abc transporter atp-binding protein
I6J39_RS29540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J39_RS29545	COG0765	amino acid transport
I6J39_RS29550	COG0765	amino acid transport
I6J39_RS29565	COG1024	Enoyl-CoA hydratase
I6J39_RS29565	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS29570	COG0183	Belongs to the thiolase family
I6J39_RS29580	COG0405	Gamma-glutamyltransferase
I6J39_RS29615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J39_RS29705	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS29725	COG0463	Glycosyl transferase, family 2
I6J39_RS29735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J39_RS29750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS29765	COG0175	sulfate reduction
I6J39_RS29770	COG2895	sulfate adenylyltransferase (ATP) activity
I6J39_RS29815	COG0626	cystathionine gamma-synthase activity
I6J39_RS29830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS29885	COG0095	Lipoate-protein ligase
I6J39_RS29905	COG1024	Enoyl-CoA hydratase
I6J39_RS29910	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS29930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J39_RS29945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J39_RS29985	COG1024	Enoyl-CoA hydratase
I6J39_RS29990	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS30020	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS30025	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS30030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J39_RS30035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J39_RS30045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS30055	COG1131	(ABC) transporter
I6J39_RS30060	COG1024	Enoyl-CoA hydratase
I6J39_RS30095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J39_RS30125	COG1929	Belongs to the glycerate kinase type-1 family
I6J39_RS30160	COG0688	phosphatidylethanolamine metabolic process
I6J39_RS30165	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS30175	COG2301	Belongs to the HpcH HpaI aldolase family
I6J39_RS30180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J39_RS30180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J39_RS30185	COG0604	alcohol dehydrogenase
I6J39_RS30205	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS30215	COG0596	Alpha beta hydrolase
I6J39_RS30245	COG0583	DNA-binding transcription factor activity
I6J39_RS30250	COG0667	Aldo Keto reductase
I6J39_RS30270	COG2362	D-Aminopeptidase
I6J39_RS30275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J39_RS30285	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J39_RS30340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J39_RS30355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J39_RS30355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J39_RS30365	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J39_RS30375	COG0702	epimerase
I6J39_RS30385	COG4106	trans-aconitate 2-methyltransferase activity
I6J39_RS30390	COG0300	oxidoreductase activity
I6J39_RS30420	COG0656	L-ascorbic acid biosynthetic process
I6J39_RS30435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J39_RS30440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J39_RS30450	COG1129	ABC transporter
I6J39_RS30455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J39_RS30460	COG1879	ABC-type sugar transport system periplasmic component
I6J39_RS30465	COG0673	inositol 2-dehydrogenase activity
I6J39_RS30485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J39_RS30500	COG0084	hydrolase, TatD family'
I6J39_RS30580	COG3321	synthase
I6J39_RS30580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS30580	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS30580	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS30580	COG0300	oxidoreductase activity
I6J39_RS30585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J39_RS30600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS30605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS30610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS30610	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J39_RS30610	COG3321	synthase
I6J39_RS30630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS30640	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS30665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J39_RS30670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS30675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J39_RS30680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J39_RS30685	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS30705	COG0477	Major facilitator Superfamily
I6J39_RS30710	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS30720	COG1129	ABC transporter
I6J39_RS30725	COG1879	ABC-type sugar transport system periplasmic component
I6J39_RS30730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J39_RS30735	COG1869	D-ribose catabolic process
I6J39_RS30745	COG0714	Associated with various cellular activities
I6J39_RS30760	COG3568	Endonuclease Exonuclease Phosphatase
I6J39_RS30775	COG5002	protein histidine kinase activity
I6J39_RS30780	COG0745	RESPONSE REGULATOR receiver
I6J39_RS30810	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS30820	COG4175	Glycine betaine
I6J39_RS30820	COG0517	IMP dehydrogenase activity
I6J39_RS30825	COG4176	ABC-type proline glycine betaine transport system permease component
I6J39_RS30865	COG0488	(ABC) transporter
I6J39_RS30875	COG1070	Carbohydrate kinase
I6J39_RS30885	COG1940	carbohydrate kinase activity
I6J39_RS30935	COG2124	cytochrome p450
I6J39_RS30940	COG1486	melibiose metabolic process
I6J39_RS30970	COG3012	SEC-C Motif Domain Protein
I6J39_RS30995	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS31040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J39_RS31065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J39_RS31105	COG2326	polyphosphate kinase activity
I6J39_RS31110	COG1793	dna ligase
I6J39_RS31160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J39_RS31175	COG0488	(ABC) transporter
I6J39_RS31200	COG1515	deoxyribonuclease V activity
I6J39_RS31210	COG3268	Saccharopine dehydrogenase
I6J39_RS31215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J39_RS31220	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS31225	COG0183	Belongs to the thiolase family
I6J39_RS31230	COG1024	Enoyl-CoA hydratase
I6J39_RS31230	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J39_RS31235	COG0789	Transcriptional regulator
I6J39_RS31260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J39_RS31275	COG0488	(ABC) transporter
I6J39_RS31295	COG4977	sequence-specific DNA binding
I6J39_RS31305	COG1024	Enoyl-CoA hydratase
I6J39_RS31320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J39_RS31350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J39_RS31370	COG1134	teichoic acid transport
I6J39_RS31375	COG1562	ergosterol biosynthetic process
I6J39_RS31385	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J39_RS31395	COG1657	PFAM Prenyltransferase squalene oxidase
I6J39_RS31435	COG2755	lipolytic protein G-D-S-L family
I6J39_RS31445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J39_RS31485	COG3467	pyridoxamine 5'-phosphate
I6J39_RS31495	COG0789	Transcriptional regulator
I6J39_RS31550	COG3958	Transketolase
I6J39_RS31555	COG3959	Transketolase, thiamine diphosphate binding domain
I6J39_RS31565	COG0318	PFAM AMP-dependent synthetase and ligase
I6J39_RS31575	COG1733	regulation of RNA biosynthetic process
I6J39_RS31585	COG0789	Transcriptional regulator
I6J39_RS31600	COG3511	phospholipase C
I6J39_RS31610	COG2197	response regulator
I6J39_RS31615	COG3851	Histidine kinase
I6J39_RS31650	COG2197	response regulator
I6J39_RS31685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J39_RS31690	COG2423	ornithine cyclodeaminase activity
I6J39_RS31695	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS31700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J39_RS31735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J39_RS31750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS31775	COG1280	lysine exporter protein (LysE YggA)
I6J39_RS31830	COG1902	pentaerythritol trinitrate reductase activity
I6J39_RS31830	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J39_RS31840	COG2409	Drug exporters of the RND superfamily
I6J39_RS31845	COG1846	Transcriptional regulator
I6J39_RS31895	COG2130	NADP-dependent
I6J39_RS31905	COG4948	Mandelate Racemase Muconate Lactonizing
I6J39_RS31910	COG0395	ABC-type sugar transport system, permease component
I6J39_RS31915	COG1175	transmembrane transport
I6J39_RS31930	COG2226	methyltransferase
I6J39_RS31950	COG3647	Membrane
I6J39_RS31955	COG2188	Transcriptional regulator
I6J39_RS31960	COG1742	UPF0060 membrane protein
I6J39_RS31975	COG1794	racemase activity, acting on amino acids and derivatives
I6J39_RS32005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J39_RS32015	COG0019	diaminopimelate decarboxylase activity
I6J39_RS32020	COG2837	iron assimilation
I6J39_RS32025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J39_RS32040	COG1119	ATPase activity
I6J39_RS32050	COG1595	DNA-templated transcription, initiation
I6J39_RS32080	COG0596	Alpha beta hydrolase
I6J39_RS32090	COG1028	Short-chain dehydrogenase reductase Sdr
I6J39_RS32100	COG1652	LysM domain
I6J39_RS32125	COG2208	phosphoserine phosphatase activity
I6J39_RS32135	COG0784	Response regulator, receiver
I6J39_RS32140	COG4251	negative regulation of phosphorylation
I6J39_RS32145	COG2201	protein-glutamate methylesterase activity
I6J39_RS32150	COG1191	sigma factor activity
I6J39_RS32190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J39_RS32205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J39_RS32210	COG3275	phosphorelay sensor kinase activity
I6J39_RS32280	COG0583	DNA-binding transcription factor activity
I6J39_RS32290	COG1053	succinate dehydrogenase
I6J39_RS32295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J39_RS32305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J39_RS32315	COG3360	Dodecin
I6J39_RS32320	COG1653	transport
I6J39_RS32335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J39_RS32340	COG0121	glutamine amidotransferase
I6J39_RS32345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J39_RS32365	COG1609	Transcriptional regulator
I6J39_RS32375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J39_RS32380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J39_RS32400	COG0714	Associated with various cellular activities
I6J39_RS32420	COG1191	sigma factor activity
I6J39_RS32430	COG2045	Belongs to the ComB family
I6J39_RS32435	COG1834	amidinotransferase
I6J39_RS32445	COG1228	amidohydrolase
I6J39_RS32450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J39_RS32465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J39_RS32540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J39_RS32560	COG0463	Glycosyl transferase, family 2
I6J39_RS32625	COG0477	Major facilitator Superfamily
I6J39_RS32635	COG0254	rRNA binding
I6J39_RS32640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J39_RS32645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J39_RS32650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J39_RS32665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS32670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS32675	COG1120	ATPase activity
I6J39_RS32700	COG1132	(ABC) transporter
I6J39_RS32705	COG1132	(ABC) transporter
I6J39_RS32730	COG2304	oxidoreductase activity
I6J39_RS32750	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS32755	COG0726	polysaccharide deacetylase
I6J39_RS32775	COG0438	transferase activity, transferring glycosyl groups
I6J39_RS32775	COG0297	glycogen (starch) synthase activity
I6J39_RS32790	COG1174	glycine betaine transport
I6J39_RS32795	COG1174	glycine betaine transport
I6J39_RS32810	COG0517	IMP dehydrogenase activity
I6J39_RS32810	COG1125	glycine betaine transport
I6J39_RS32840	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS32845	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS32860	COG0601	transmembrane transport
I6J39_RS32865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J39_RS32870	COG0444	Belongs to the ABC transporter superfamily
I6J39_RS32970	COG1796	DNA polymerase
I6J39_RS32970	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J39_RS33030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J39_RS33055	COG1278	Cold shock
I6J39_RS33060	COG0477	Major facilitator Superfamily
I6J39_RS33075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J39_RS33100	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J39_RS33120	COG1063	alcohol dehydrogenase
I6J39_RS33140	COG1349	DNA-binding transcription factor activity
I6J39_RS33160	COG0789	Transcriptional regulator
I6J39_RS33165	COG1960	acyl-CoA dehydrogenase activity
I6J39_RS33185	COG1012	belongs to the aldehyde dehydrogenase family
I6J39_RS33195	COG0385	Bile acid
I6J39_RS33240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J39_RS33280	COG0640	Transcriptional regulator
I6J39_RS33295	COG2018	Roadblock/LC7 domain
I6J39_RS33305	COG0456	acetyltransferase
I6J39_RS33320	COG1024	Enoyl-CoA hydratase
I6J39_RS33335	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J39_RS33345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J39_RS33355	COG2340	Cysteine-rich secretory protein family
I6J39_RS33395	COG0488	(ABC) transporter
I6J39_RS33415	COG0009	L-threonylcarbamoyladenylate synthase
I6J39_RS33440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J39_RS33455	COG2318	DinB family
I6J39_RS33465	COG1609	Transcriptional regulator
I6J39_RS33480	COG0395	ABC-type sugar transport system, permease component
I6J39_RS33485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J39_RS33490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS33500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J39_RS33510	COG0714	Associated with various cellular activities
I6J39_RS33515	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J39_RS33545	COG2205	protein histidine kinase activity
I6J39_RS33550	COG0745	RESPONSE REGULATOR receiver
I6J39_RS33565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J39_RS33570	COG1120	ATPase activity
I6J39_RS33585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J39_RS33635	COG0586	Pfam SNARE associated Golgi protein
I6J39_RS33650	COG2226	methyltransferase
I6J39_RS33655	COG0745	RESPONSE REGULATOR receiver
I6J39_RS33660	COG2205	protein histidine kinase activity
I6J39_RS33670	COG1404	Belongs to the peptidase S8 family
I6J39_RS33695	COG1595	DNA-templated transcription, initiation
I6J39_RS33705	COG0831	urea catabolic process
I6J39_RS33710	COG0832	Belongs to the urease beta subunit family
I6J39_RS33720	COG0830	nickel cation binding
I6J39_RS33725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J39_RS33730	COG0829	nickel cation binding
I6J39_RS33740	COG4214	carbohydrate transport
I6J39_RS33750	COG4213	ABC transporter substrate-binding protein
I6J39_RS33760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J39_RS33765	COG0406	alpha-ribazole phosphatase activity
I6J39_RS33775	COG1070	Carbohydrate kinase
I6J39_RS33830	COG0395	ABC-type sugar transport system, permease component
I6J39_RS33855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J39_RS33880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J39_RS33905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J39_RS33925	COG0312	modulator of DNA gyrase
I6J39_RS33950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J39_RS34210	COG3328	transposase activity
I6J39_RS34275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J39_RS34320	COG1192	Involved in chromosome partitioning
I6J39_RS34425	COG4974	Belongs to the 'phage' integrase family
I6J39_RS34515	COG2188	Transcriptional regulator
I6J39_RS34570	COG1518	maintenance of DNA repeat elements
I6J39_RS34575	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J39_RS34590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J39_RS34605	COG0302	gtp cyclohydrolase
I6J39_RS34620	COG0720	synthase
I6J39_RS34645	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J39_RS34655	COG4264	IucA IucC family
I6J39_RS34685	COG1051	belongs to the nudix hydrolase family
I6J39_RS34725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J39_RS34730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J39_RS34825	COG2815	serine threonine protein kinase
I6J39_RS34825	COG0515	serine threonine protein kinase
I6J39_RS34850	COG1396	sequence-specific DNA binding
I6J39_RS34885	COG3293	Transposase