locus-tag	class	description
I6J40_RS00050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J40_RS00075	COG0312	modulator of DNA gyrase
I6J40_RS00095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J40_RS00120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J40_RS00145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS00170	COG0395	ABC-type sugar transport system, permease component
I6J40_RS00225	COG1070	Carbohydrate kinase
I6J40_RS00235	COG0406	alpha-ribazole phosphatase activity
I6J40_RS00240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J40_RS00250	COG4213	ABC transporter substrate-binding protein
I6J40_RS00260	COG4214	carbohydrate transport
I6J40_RS00270	COG0829	nickel cation binding
I6J40_RS00275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J40_RS00280	COG0830	nickel cation binding
I6J40_RS00290	COG0832	Belongs to the urease beta subunit family
I6J40_RS00295	COG0831	urea catabolic process
I6J40_RS00305	COG1595	DNA-templated transcription, initiation
I6J40_RS00330	COG1404	Belongs to the peptidase S8 family
I6J40_RS00340	COG2205	protein histidine kinase activity
I6J40_RS00345	COG0745	RESPONSE REGULATOR receiver
I6J40_RS00350	COG2226	methyltransferase
I6J40_RS00365	COG0586	Pfam SNARE associated Golgi protein
I6J40_RS00415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J40_RS00430	COG1120	ATPase activity
I6J40_RS00435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS00450	COG0745	RESPONSE REGULATOR receiver
I6J40_RS00455	COG2205	protein histidine kinase activity
I6J40_RS00485	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J40_RS00490	COG0714	Associated with various cellular activities
I6J40_RS00500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J40_RS00510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS00515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J40_RS00520	COG0395	ABC-type sugar transport system, permease component
I6J40_RS00535	COG1609	Transcriptional regulator
I6J40_RS00545	COG2318	DinB family
I6J40_RS00560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J40_RS00585	COG0009	L-threonylcarbamoyladenylate synthase
I6J40_RS00605	COG0488	(ABC) transporter
I6J40_RS00645	COG2340	Cysteine-rich secretory protein family
I6J40_RS00655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J40_RS00665	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J40_RS00680	COG1024	Enoyl-CoA hydratase
I6J40_RS00695	COG0456	acetyltransferase
I6J40_RS00705	COG2018	Roadblock/LC7 domain
I6J40_RS00720	COG0640	Transcriptional regulator
I6J40_RS00760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J40_RS00805	COG0385	Bile acid
I6J40_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS00835	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS00840	COG0789	Transcriptional regulator
I6J40_RS00860	COG1349	DNA-binding transcription factor activity
I6J40_RS00880	COG1063	alcohol dehydrogenase
I6J40_RS00900	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J40_RS00905	COG1132	(ABC) transporter
I6J40_RS00915	COG0596	Alpha beta hydrolase
I6J40_RS00925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J40_RS00940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS00955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS00960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS00970	COG0693	protein deglycase activity
I6J40_RS00975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J40_RS00990	COG0477	Major facilitator Superfamily
I6J40_RS00995	COG1278	Cold shock
I6J40_RS01020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J40_RS01080	COG1796	DNA polymerase
I6J40_RS01080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J40_RS01180	COG0444	Belongs to the ABC transporter superfamily
I6J40_RS01185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS01190	COG0601	transmembrane transport
I6J40_RS01205	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS01210	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS01240	COG1125	glycine betaine transport
I6J40_RS01240	COG0517	IMP dehydrogenase activity
I6J40_RS01255	COG1174	glycine betaine transport
I6J40_RS01260	COG1174	glycine betaine transport
I6J40_RS01275	COG0297	glycogen (starch) synthase activity
I6J40_RS01275	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS01290	COG0728	peptidoglycan biosynthetic process
I6J40_RS01295	COG0726	polysaccharide deacetylase
I6J40_RS01300	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS01320	COG2304	oxidoreductase activity
I6J40_RS01345	COG1132	(ABC) transporter
I6J40_RS01375	COG1120	ATPase activity
I6J40_RS01380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS01385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS01400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J40_RS01405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J40_RS01410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J40_RS01415	COG0254	rRNA binding
I6J40_RS01425	COG0477	Major facilitator Superfamily
I6J40_RS01490	COG0463	Glycosyl transferase, family 2
I6J40_RS01510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J40_RS01570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J40_RS01575	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6J40_RS01580	COG3971	2-oxopent-4-enoate hydratase activity
I6J40_RS01605	COG3971	2-oxopent-4-enoate hydratase activity
I6J40_RS01615	COG0477	Major facilitator Superfamily
I6J40_RS01670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J40_RS01685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J40_RS01690	COG1228	amidohydrolase
I6J40_RS01700	COG1834	amidinotransferase
I6J40_RS01705	COG2045	Belongs to the ComB family
I6J40_RS01715	COG1191	sigma factor activity
I6J40_RS01735	COG0714	Associated with various cellular activities
I6J40_RS01770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J40_RS01775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J40_RS01785	COG1609	Transcriptional regulator
I6J40_RS01805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J40_RS01810	COG0121	glutamine amidotransferase
I6J40_RS01815	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J40_RS01830	COG1653	transport
I6J40_RS01835	COG3360	Dodecin
I6J40_RS01845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS01855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J40_RS01860	COG1053	succinate dehydrogenase
I6J40_RS01870	COG0583	DNA-binding transcription factor activity
I6J40_RS01940	COG3275	phosphorelay sensor kinase activity
I6J40_RS01945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J40_RS01960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J40_RS02000	COG1191	sigma factor activity
I6J40_RS02005	COG2201	protein-glutamate methylesterase activity
I6J40_RS02010	COG4251	negative regulation of phosphorylation
I6J40_RS02015	COG0784	Response regulator, receiver
I6J40_RS02025	COG2208	phosphoserine phosphatase activity
I6J40_RS02050	COG1652	LysM domain
I6J40_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS02070	COG0596	Alpha beta hydrolase
I6J40_RS02100	COG1595	DNA-templated transcription, initiation
I6J40_RS02110	COG1119	ATPase activity
I6J40_RS02125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J40_RS02130	COG2837	iron assimilation
I6J40_RS02135	COG0019	diaminopimelate decarboxylase activity
I6J40_RS02145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J40_RS02180	COG1794	racemase activity, acting on amino acids and derivatives
I6J40_RS02195	COG1742	UPF0060 membrane protein
I6J40_RS02200	COG2188	Transcriptional regulator
I6J40_RS02205	COG3647	Membrane
I6J40_RS02225	COG2226	methyltransferase
I6J40_RS02240	COG1175	transmembrane transport
I6J40_RS02245	COG0395	ABC-type sugar transport system, permease component
I6J40_RS02250	COG4948	Mandelate Racemase Muconate Lactonizing
I6J40_RS02260	COG2130	NADP-dependent
I6J40_RS02310	COG1846	Transcriptional regulator
I6J40_RS02315	COG2409	Drug exporters of the RND superfamily
I6J40_RS02325	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J40_RS02325	COG1902	pentaerythritol trinitrate reductase activity
I6J40_RS02380	COG1280	lysine exporter protein (LysE YggA)
I6J40_RS02405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS02420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J40_RS02460	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS02465	COG2423	ornithine cyclodeaminase activity
I6J40_RS02470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J40_RS02475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS02505	COG2197	response regulator
I6J40_RS02545	COG3851	Histidine kinase
I6J40_RS02550	COG2197	response regulator
I6J40_RS02560	COG3511	phospholipase C
I6J40_RS02575	COG0789	Transcriptional regulator
I6J40_RS02585	COG1733	regulation of RNA biosynthetic process
I6J40_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS02605	COG3959	Transketolase, thiamine diphosphate binding domain
I6J40_RS02610	COG3958	Transketolase
I6J40_RS02665	COG0789	Transcriptional regulator
I6J40_RS02720	COG3467	pyridoxamine 5'-phosphate
I6J40_RS02760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J40_RS02770	COG2755	lipolytic protein G-D-S-L family
I6J40_RS02810	COG1657	PFAM Prenyltransferase squalene oxidase
I6J40_RS02820	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J40_RS02830	COG1562	ergosterol biosynthetic process
I6J40_RS02835	COG1134	teichoic acid transport
I6J40_RS02855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J40_RS02885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J40_RS02900	COG1024	Enoyl-CoA hydratase
I6J40_RS02910	COG4977	sequence-specific DNA binding
I6J40_RS02925	COG2226	methyltransferase
I6J40_RS02930	COG0488	(ABC) transporter
I6J40_RS02945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J40_RS02970	COG0789	Transcriptional regulator
I6J40_RS02975	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS02975	COG1024	Enoyl-CoA hydratase
I6J40_RS02980	COG0183	Belongs to the thiolase family
I6J40_RS02985	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS02990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J40_RS02995	COG3268	Saccharopine dehydrogenase
I6J40_RS03005	COG1515	deoxyribonuclease V activity
I6J40_RS03045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J40_RS03095	COG1793	dna ligase
I6J40_RS03100	COG2326	polyphosphate kinase activity
I6J40_RS03140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J40_RS03165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J40_RS03210	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS03235	COG3012	SEC-C Motif Domain Protein
I6J40_RS03265	COG1486	melibiose metabolic process
I6J40_RS03320	COG1940	carbohydrate kinase activity
I6J40_RS03330	COG1070	Carbohydrate kinase
I6J40_RS03340	COG0488	(ABC) transporter
I6J40_RS03380	COG4176	ABC-type proline glycine betaine transport system permease component
I6J40_RS03385	COG4175	Glycine betaine
I6J40_RS03385	COG0517	IMP dehydrogenase activity
I6J40_RS03395	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS03425	COG0745	RESPONSE REGULATOR receiver
I6J40_RS03430	COG5002	protein histidine kinase activity
I6J40_RS03445	COG3568	Endonuclease Exonuclease Phosphatase
I6J40_RS03460	COG0714	Associated with various cellular activities
I6J40_RS03470	COG1869	D-ribose catabolic process
I6J40_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J40_RS03480	COG1879	ABC-type sugar transport system periplasmic component
I6J40_RS03485	COG1129	ABC transporter
I6J40_RS03495	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS03500	COG0477	Major facilitator Superfamily
I6J40_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS03525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J40_RS03530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J40_RS03535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS03540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS03575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS03595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS03595	COG3321	synthase
I6J40_RS03595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J40_RS03600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS03605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS03620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J40_RS03625	COG0300	oxidoreductase activity
I6J40_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS03625	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS03625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS03625	COG3321	synthase
I6J40_RS03705	COG0084	hydrolase, TatD family'
I6J40_RS03720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J40_RS03740	COG0673	inositol 2-dehydrogenase activity
I6J40_RS03745	COG1879	ABC-type sugar transport system periplasmic component
I6J40_RS03750	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J40_RS03755	COG1129	ABC transporter
I6J40_RS03765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J40_RS03770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J40_RS03785	COG0656	L-ascorbic acid biosynthetic process
I6J40_RS03815	COG0300	oxidoreductase activity
I6J40_RS03820	COG4106	trans-aconitate 2-methyltransferase activity
I6J40_RS03830	COG0702	epimerase
I6J40_RS03840	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J40_RS03850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J40_RS03850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J40_RS03865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J40_RS03920	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J40_RS03930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J40_RS03935	COG2362	D-Aminopeptidase
I6J40_RS03955	COG0667	Aldo Keto reductase
I6J40_RS03960	COG0583	DNA-binding transcription factor activity
I6J40_RS04305	COG0741	lytic transglycosylase activity
I6J40_RS04305	COG1196	nuclear chromosome segregation
I6J40_RS04305	COG0739	heme binding
I6J40_RS04445	COG0596	Alpha beta hydrolase
I6J40_RS04455	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS04475	COG0604	alcohol dehydrogenase
I6J40_RS04480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J40_RS04480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J40_RS04485	COG2301	Belongs to the HpcH HpaI aldolase family
I6J40_RS04495	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS04500	COG0688	phosphatidylethanolamine metabolic process
I6J40_RS04535	COG1929	Belongs to the glycerate kinase type-1 family
I6J40_RS04570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J40_RS04595	COG0483	inositol monophosphate 1-phosphatase activity
I6J40_RS04605	COG1024	Enoyl-CoA hydratase
I6J40_RS04610	COG1131	(ABC) transporter
I6J40_RS04620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS04630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J40_RS04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J40_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS04675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS04680	COG1024	Enoyl-CoA hydratase
I6J40_RS04725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J40_RS04740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J40_RS04760	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS04765	COG1024	Enoyl-CoA hydratase
I6J40_RS04785	COG0095	Lipoate-protein ligase
I6J40_RS04840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS04855	COG0626	cystathionine gamma-synthase activity
I6J40_RS04900	COG2895	sulfate adenylyltransferase (ATP) activity
I6J40_RS04905	COG0175	sulfate reduction
I6J40_RS04920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS04935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J40_RS04945	COG0463	Glycosyl transferase, family 2
I6J40_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS05055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J40_RS05090	COG0405	Gamma-glutamyltransferase
I6J40_RS05095	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS05100	COG1309	transcriptional regulator
I6J40_RS05110	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS05130	COG0183	Belongs to the thiolase family
I6J40_RS05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS05135	COG1024	Enoyl-CoA hydratase
I6J40_RS05150	COG0765	amino acid transport
I6J40_RS05155	COG0765	amino acid transport
I6J40_RS05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS05165	COG1126	abc transporter atp-binding protein
I6J40_RS05200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J40_RS05205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J40_RS05215	COG1940	carbohydrate kinase activity
I6J40_RS05220	COG1129	ABC transporter
I6J40_RS05235	COG2188	Transcriptional regulator
I6J40_RS05240	COG0673	inositol 2-dehydrogenase activity
I6J40_RS05255	COG2197	response regulator
I6J40_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS05280	COG0656	L-ascorbic acid biosynthetic process
I6J40_RS05290	COG4266	Belongs to the allantoicase family
I6J40_RS05295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J40_RS05300	COG1414	Transcriptional regulator
I6J40_RS05320	COG2197	response regulator
I6J40_RS05335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J40_RS05340	COG0242	peptide deformylase activity
I6J40_RS05370	COG1288	antiporter activity
I6J40_RS05395	COG2233	PERMEase
I6J40_RS05405	COG2233	PERMEase
I6J40_RS05415	COG2351	hydroxyisourate hydrolase activity
I6J40_RS05435	COG2706	6-phosphogluconolactonase activity
I6J40_RS05440	COG3622	Belongs to the hyi family
I6J40_RS05445	COG2084	Dehydrogenase
I6J40_RS05450	COG0753	catalase activity
I6J40_RS05475	COG3960	tartronate-semialdehyde synthase activity
I6J40_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS05500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J40_RS05505	COG2197	response regulator
I6J40_RS05520	COG0435	Glutathione S-transferase
I6J40_RS05550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS05575	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J40_RS05575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J40_RS05580	COG2252	PERMEase
I6J40_RS05585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J40_RS05610	COG1802	Transcriptional regulator
I6J40_RS05630	COG0028	Belongs to the TPP enzyme family
I6J40_RS05640	COG1404	Belongs to the peptidase S8 family
I6J40_RS05660	COG1162	GTPase activity
I6J40_RS05710	COG0183	Belongs to the thiolase family
I6J40_RS05715	COG0583	DNA-binding transcription factor activity
I6J40_RS05720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J40_RS05725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J40_RS05730	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS05755	COG0583	DNA-binding transcription factor activity
I6J40_RS05780	COG1917	Cupin 2, conserved barrel domain protein
I6J40_RS05795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J40_RS05800	COG3844	kynureninase activity
I6J40_RS05835	COG0175	sulfate reduction
I6J40_RS05840	COG0529	Catalyzes the synthesis of activated sulfate
I6J40_RS05860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J40_RS05865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J40_RS05875	COG2226	methyltransferase
I6J40_RS05880	COG1120	ATPase activity
I6J40_RS05885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS05890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS05895	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J40_RS05900	COG1132	(ABC) transporter
I6J40_RS05905	COG1132	(ABC) transporter
I6J40_RS05925	COG1404	Belongs to the peptidase S8 family
I6J40_RS05945	COG1175	transmembrane transport
I6J40_RS06000	COG2723	6-phospho-beta-galactosidase activity
I6J40_RS06020	COG1072	(Pantothenic acid kinase))
I6J40_RS06025	COG0346	lactoylglutathione lyase activity
I6J40_RS06035	COG0583	DNA-binding transcription factor activity
I6J40_RS06040	COG0156	8-amino-7-oxononanoate synthase activity
I6J40_RS06045	COG1063	alcohol dehydrogenase
I6J40_RS06155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J40_RS06160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J40_RS06220	COG2945	thiolester hydrolase activity
I6J40_RS06220	COG0596	Alpha beta hydrolase
I6J40_RS06230	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J40_RS06260	COG3220	belongs to the UPF0276 family
I6J40_RS06275	COG3253	May function as heme-dependent peroxidase
I6J40_RS06280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J40_RS06290	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J40_RS06295	COG0745	RESPONSE REGULATOR receiver
I6J40_RS06310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J40_RS06335	COG0183	Belongs to the thiolase family
I6J40_RS06340	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS06340	COG1024	Enoyl-CoA hydratase
I6J40_RS06355	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS06380	COG0531	amino acid
I6J40_RS06385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J40_RS06390	COG4214	carbohydrate transport
I6J40_RS06400	COG4213	ABC transporter substrate-binding protein
I6J40_RS06405	COG1940	carbohydrate kinase activity
I6J40_RS06410	COG0395	ABC-type sugar transport system, permease component
I6J40_RS06415	COG1175	transmembrane transport
I6J40_RS06420	COG1653	transport
I6J40_RS06430	COG0588	phosphoglycerate mutase activity
I6J40_RS06445	COG0494	nUDIX hydrolase
I6J40_RS06450	COG0494	nUDIX hydrolase
I6J40_RS06455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J40_RS06485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J40_RS06500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS06520	COG0475	glutathione-regulated potassium exporter activity
I6J40_RS06545	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS06555	COG0300	oxidoreductase activity
I6J40_RS06570	COG3629	intracellular signal transduction
I6J40_RS06570	COG3903	Transcriptional regulator
I6J40_RS06575	COG0477	Major facilitator Superfamily
I6J40_RS06615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J40_RS06635	COG2197	response regulator
I6J40_RS06650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J40_RS06655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J40_RS06660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J40_RS06695	COG0489	protein tyrosine kinase activity
I6J40_RS06700	COG0297	glycogen (starch) synthase activity
I6J40_RS06715	COG1320	monovalent cation:proton antiporter activity
I6J40_RS06730	COG0651	ATP synthesis coupled electron transport
I6J40_RS06735	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J40_RS06740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J40_RS06740	COG2111	Na H antiporter
I6J40_RS06780	COG1024	Enoyl-CoA hydratase
I6J40_RS06790	COG0531	amino acid
I6J40_RS06795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J40_RS06805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J40_RS06815	COG2040	homocysteine
I6J40_RS06835	COG1799	cell septum assembly
I6J40_RS06840	COG1349	DNA-binding transcription factor activity
I6J40_RS06845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J40_RS06850	COG0586	Pfam SNARE associated Golgi protein
I6J40_RS06860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS06865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS06895	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J40_RS06900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J40_RS06905	COG1280	lysine exporter protein (LysE YggA)
I6J40_RS06915	COG3291	Pkd domain containing protein
I6J40_RS06930	COG0601	transmembrane transport
I6J40_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS06945	COG0006	proline dipeptidase activity
I6J40_RS06950	COG1802	Transcriptional regulator
I6J40_RS06955	COG2423	ornithine cyclodeaminase activity
I6J40_RS06965	COG3938	Belongs to the proline racemase family
I6J40_RS06975	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J40_RS06995	COG0596	Alpha beta hydrolase
I6J40_RS07010	COG2814	Major facilitator Superfamily
I6J40_RS07055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J40_RS07075	COG4552	Acetyltransferase involved in intracellular survival and related
I6J40_RS07080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J40_RS07115	COG3335	DDE superfamily endonuclease
I6J40_RS07140	COG3415	Transposase
I6J40_RS07140	COG2801	Transposase and inactivated derivatives
I6J40_RS07205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J40_RS07210	COG0531	amino acid
I6J40_RS07215	COG0569	domain protein
I6J40_RS07245	COG1136	(ABC) transporter
I6J40_RS07245	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J40_RS07255	COG0756	dUTP diphosphatase activity
I6J40_RS07280	COG2205	protein histidine kinase activity
I6J40_RS07285	COG0745	RESPONSE REGULATOR receiver
I6J40_RS07300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J40_RS07340	COG1435	thymidine kinase activity
I6J40_RS07355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J40_RS07355	COG1042	CoA-binding domain protein
I6J40_RS07355	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J40_RS07360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J40_RS07365	COG1802	Transcriptional regulator
I6J40_RS07380	COG0612	Peptidase, M16
I6J40_RS07385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J40_RS07395	COG0372	Belongs to the citrate synthase family
I6J40_RS07400	COG0372	Belongs to the citrate synthase family
I6J40_RS07405	COG3290	protein histidine kinase activity
I6J40_RS07410	COG4565	transcriptional regulatory protein
I6J40_RS07415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J40_RS07440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J40_RS07445	COG2186	Transcriptional regulator
I6J40_RS07480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J40_RS07510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J40_RS07515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J40_RS07520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J40_RS07560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J40_RS07570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J40_RS07575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J40_RS07585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J40_RS07600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J40_RS07605	COG2358	TRAP transporter, solute receptor (TAXI family
I6J40_RS07610	COG2205	protein histidine kinase activity
I6J40_RS07620	COG1126	abc transporter atp-binding protein
I6J40_RS07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS07630	COG0765	amino acid transport
I6J40_RS07635	COG0765	amino acid transport
I6J40_RS07665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J40_RS07695	COG2207	Transcriptional regulator
I6J40_RS07695	COG1917	Cupin 2, conserved barrel domain protein
I6J40_RS07700	COG1201	RNA secondary structure unwinding
I6J40_RS07705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J40_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS07720	COG0783	Belongs to the Dps family
I6J40_RS07725	COG1396	sequence-specific DNA binding
I6J40_RS07730	COG1058	Belongs to the CinA family
I6J40_RS07730	COG1546	Belongs to the CinA family
I6J40_RS07740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J40_RS07750	COG1674	ftsk spoiiie
I6J40_RS07760	COG4999	Histidine kinase
I6J40_RS07760	COG3850	Histidine kinase
I6J40_RS07760	COG2205	protein histidine kinase activity
I6J40_RS07760	COG3437	response regulator, receiver
I6J40_RS07790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J40_RS07795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J40_RS07800	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J40_RS07820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J40_RS07825	COG0612	Peptidase, M16
I6J40_RS07830	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J40_RS07835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J40_RS07845	COG1674	ftsk spoiiie
I6J40_RS07860	COG1404	Belongs to the peptidase S8 family
I6J40_RS07875	COG1404	Belongs to the peptidase S8 family
I6J40_RS07880	COG3266	domain, Protein
I6J40_RS07900	COG0455	bacterial-type flagellum organization
I6J40_RS07905	COG0747	negative chemotaxis
I6J40_RS07910	COG0601	transmembrane transport
I6J40_RS07915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS07925	COG4608	Belongs to the ABC transporter superfamily
I6J40_RS07955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J40_RS07960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J40_RS07970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J40_RS07985	COG0779	Required for maturation of 30S ribosomal subunits
I6J40_RS08005	COG0442	prolyl-tRNA aminoacylation
I6J40_RS08020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J40_RS08025	COG0750	zinc metalloprotease
I6J40_RS08030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J40_RS08035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J40_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS08045	COG2814	Major facilitator Superfamily
I6J40_RS08055	COG2508	Transcriptional regulator
I6J40_RS08085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J40_RS08090	COG1177	transmembrane transport
I6J40_RS08095	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J40_RS08100	COG3842	ATPase activity
I6J40_RS08105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J40_RS08130	COG1595	DNA-templated transcription, initiation
I6J40_RS08155	COG2801	Transposase and inactivated derivatives
I6J40_RS08155	COG3415	Transposase
I6J40_RS08175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J40_RS08200	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS08210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J40_RS08215	COG1136	(ABC) transporter
I6J40_RS08225	COG3842	ATPase activity
I6J40_RS08240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J40_RS08250	COG2188	Transcriptional regulator
I6J40_RS08350	COG0575	Belongs to the CDS family
I6J40_RS08355	COG0233	cytoplasmic translational termination
I6J40_RS08360	COG0528	UMP kinase activity
I6J40_RS08365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J40_RS08370	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J40_RS08385	COG1191	sigma factor activity
I6J40_RS08400	COG0792	nuclease activity
I6J40_RS08410	COG1051	belongs to the nudix hydrolase family
I6J40_RS08420	COG0681	Belongs to the peptidase S26 family
I6J40_RS08435	COG0335	large ribosomal subunit rRNA binding
I6J40_RS08440	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J40_RS08445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J40_RS08450	COG1837	Belongs to the UPF0109 family
I6J40_RS08455	COG0228	four-way junction DNA binding
I6J40_RS08475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J40_RS08510	COG0477	Major facilitator Superfamily
I6J40_RS08515	COG1196	nuclear chromosome segregation
I6J40_RS08525	COG1254	Belongs to the acylphosphatase family
I6J40_RS08530	COG2340	Cysteine-rich secretory protein family
I6J40_RS08535	COG1733	regulation of RNA biosynthetic process
I6J40_RS08540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J40_RS08545	COG0571	ribonuclease III activity
I6J40_RS08550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J40_RS08565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J40_RS08570	COG0742	ribosomal rna small subunit methyltransferase
I6J40_RS08580	COG1461	Dihydroxyacetone kinase
I6J40_RS08585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J40_RS08590	COG0351	phosphomethylpyrimidine kinase
I6J40_RS08610	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J40_RS08615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J40_RS08625	COG1920	GTP binding
I6J40_RS08635	COG0776	regulation of translation
I6J40_RS08645	COG0066	3-isopropylmalate dehydratase activity
I6J40_RS08650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J40_RS08655	COG1414	Transcriptional regulator
I6J40_RS08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J40_RS08705	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J40_RS08715	COG5002	protein histidine kinase activity
I6J40_RS08720	COG2018	Roadblock/LC7 domain
I6J40_RS08740	COG2018	Roadblock/LC7 domain
I6J40_RS08760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J40_RS08765	COG0366	Alpha amylase catalytic
I6J40_RS08765	COG1470	cell adhesion involved in biofilm formation
I6J40_RS08780	COG2353	YceI-like domain
I6J40_RS08785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J40_RS08790	COG1120	ATPase activity
I6J40_RS08795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS08800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS08865	COG3708	Transcriptional regulator
I6J40_RS08865	COG2207	Transcriptional regulator
I6J40_RS08880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J40_RS08905	COG0542	response to heat
I6J40_RS08915	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J40_RS08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J40_RS08930	COG2957	Belongs to the agmatine deiminase family
I6J40_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J40_RS08945	COG0473	3-isopropylmalate dehydrogenase activity
I6J40_RS08960	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J40_RS08960	COG0778	Nitroreductase
I6J40_RS08965	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS08970	COG0506	proline dehydrogenase activity
I6J40_RS08975	COG2508	Transcriptional regulator
I6J40_RS08985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J40_RS09005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J40_RS09010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J40_RS09015	COG0440	acetolactate synthase activity
I6J40_RS09025	COG5001	Diguanylate cyclase
I6J40_RS09025	COG3300	MHYT domain
I6J40_RS09035	COG0667	Aldo Keto reductase
I6J40_RS09040	COG2133	pyrroloquinoline quinone binding
I6J40_RS09050	COG2197	response regulator
I6J40_RS09065	COG2409	Drug exporters of the RND superfamily
I6J40_RS09075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J40_RS09080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J40_RS09090	COG0154	amidase activity
I6J40_RS09095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J40_RS09105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J40_RS09115	COG4221	oxidoreductase activity
I6J40_RS09135	COG0482	sulfurtransferase activity
I6J40_RS09165	COG2378	regulation of single-species biofilm formation
I6J40_RS09175	COG2860	membrane
I6J40_RS09180	COG4608	Belongs to the ABC transporter superfamily
I6J40_RS09190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS09195	COG0601	transmembrane transport
I6J40_RS09200	COG0747	negative chemotaxis
I6J40_RS09220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J40_RS09225	COG0509	glycine decarboxylation via glycine cleavage system
I6J40_RS09230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J40_RS09235	COG1760	l-serine dehydratase
I6J40_RS09265	COG0464	growth
I6J40_RS09275	COG0823	Involved in the tonB-independent uptake of proteins
I6J40_RS09275	COG1506	peptidase
I6J40_RS09410	COG2197	response regulator
I6J40_RS09425	COG1131	(ABC) transporter
I6J40_RS09435	COG1132	(ABC) transporter
I6J40_RS09440	COG0387	Pfam Sodium calcium exchanger
I6J40_RS09470	COG0058	SHG alpha-glucan phosphorylase activity
I6J40_RS09475	COG0366	Alpha amylase catalytic
I6J40_RS09480	COG0366	Alpha amylase catalytic
I6J40_RS09490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J40_RS09500	COG3118	belongs to the thioredoxin family
I6J40_RS09515	COG1301	dicarboxylic acid transport
I6J40_RS09520	COG3290	protein histidine kinase activity
I6J40_RS09525	COG4565	transcriptional regulatory protein
I6J40_RS09535	COG0205	6-phosphofructokinase activity
I6J40_RS09540	COG0280	phosphate acetyltransferase
I6J40_RS09540	COG0857	belongs to the CobB CobQ family
I6J40_RS09545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J40_RS09590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J40_RS09590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J40_RS09660	COG5000	phosphorelay sensor kinase activity
I6J40_RS09660	COG5002	protein histidine kinase activity
I6J40_RS09665	COG0745	RESPONSE REGULATOR receiver
I6J40_RS09680	COG0183	Belongs to the thiolase family
I6J40_RS09700	COG1131	(ABC) transporter
I6J40_RS09735	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J40_RS09750	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS09780	COG4585	Histidine kinase
I6J40_RS09785	COG2197	response regulator
I6J40_RS09800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J40_RS09805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J40_RS09810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J40_RS09815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J40_RS09820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J40_RS09825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J40_RS09830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J40_RS09850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J40_RS09855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J40_RS09865	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J40_RS09870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J40_RS09875	COG0254	rRNA binding
I6J40_RS09880	COG1316	TRANSCRIPTIONal
I6J40_RS09890	COG0083	homoserine kinase activity
I6J40_RS09895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J40_RS09900	COG0460	homoserine dehydrogenase
I6J40_RS09905	COG0019	diaminopimelate decarboxylase activity
I6J40_RS09910	COG0018	arginyl-trna synthetase
I6J40_RS09930	COG2801	Transposase and inactivated derivatives
I6J40_RS09930	COG3415	Transposase
I6J40_RS09940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J40_RS09950	COG0515	serine threonine protein kinase
I6J40_RS09955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J40_RS09960	COG1793	dna ligase
I6J40_RS09960	COG3285	dna ligase
I6J40_RS09980	COG2205	protein histidine kinase activity
I6J40_RS10030	COG1309	transcriptional regulator
I6J40_RS10070	COG5002	protein histidine kinase activity
I6J40_RS10090	COG0726	polysaccharide deacetylase
I6J40_RS10095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J40_RS10105	COG0745	RESPONSE REGULATOR receiver
I6J40_RS10110	COG2205	protein histidine kinase activity
I6J40_RS10115	COG0567	Dehydrogenase, E1 component
I6J40_RS10115	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J40_RS10140	COG0542	response to heat
I6J40_RS10160	COG0604	alcohol dehydrogenase
I6J40_RS10165	COG0281	malic enzyme
I6J40_RS10170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS10175	COG0765	amino acid transport
I6J40_RS10180	COG1126	abc transporter atp-binding protein
I6J40_RS10190	COG1595	DNA-templated transcription, initiation
I6J40_RS10195	COG4106	trans-aconitate 2-methyltransferase activity
I6J40_RS10225	COG1695	Transcriptional regulator
I6J40_RS10245	COG4585	Histidine kinase
I6J40_RS10250	COG2197	response regulator
I6J40_RS10315	COG0142	geranyltranstransferase activity
I6J40_RS10320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J40_RS10325	COG1959	2 iron, 2 sulfur cluster binding
I6J40_RS10365	COG1597	lipid kinase activity
I6J40_RS10380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J40_RS10385	COG0363	glucosamine-6-phosphate deaminase activity
I6J40_RS10390	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J40_RS10395	COG0395	ABC-type sugar transport system, permease component
I6J40_RS10400	COG1175	transmembrane transport
I6J40_RS10405	COG2182	Extracellular solute-binding protein
I6J40_RS10410	COG2188	Transcriptional regulator
I6J40_RS10415	COG1966	Carbon starvation protein
I6J40_RS10450	COG0242	peptide deformylase activity
I6J40_RS10460	COG5662	AntiSigma factor
I6J40_RS10465	COG1595	DNA-templated transcription, initiation
I6J40_RS10475	COG2135	peptidase activity
I6J40_RS10485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J40_RS10495	COG2076	Multidrug Resistance protein
I6J40_RS10505	COG0483	inositol monophosphate 1-phosphatase activity
I6J40_RS10515	COG0753	catalase activity
I6J40_RS10540	COG1615	UPF0182 protein
I6J40_RS10550	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J40_RS10650	COG0210	DNA helicase
I6J40_RS10700	COG0601	transmembrane transport
I6J40_RS10710	COG0747	negative chemotaxis
I6J40_RS10750	COG0513	Belongs to the DEAD box helicase family
I6J40_RS10760	COG1432	Conserved Protein
I6J40_RS10770	COG2095	MarC family integral membrane protein
I6J40_RS10785	COG2814	Major facilitator Superfamily
I6J40_RS10795	COG0598	Magnesium transport protein CorA
I6J40_RS10830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J40_RS10835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J40_RS10845	COG1595	DNA-templated transcription, initiation
I6J40_RS10860	COG1024	Enoyl-CoA hydratase
I6J40_RS10865	COG0519	Catalyzes the synthesis of GMP from XMP
I6J40_RS10875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J40_RS10880	COG1611	Belongs to the LOG family
I6J40_RS10885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J40_RS10915	COG2912	Transglutaminase-like superfamily
I6J40_RS10920	COG2197	response regulator
I6J40_RS10925	COG1132	(ABC) transporter
I6J40_RS10940	COG0515	serine threonine protein kinase
I6J40_RS10955	COG0110	maltose O-acetyltransferase activity
I6J40_RS10965	COG1396	sequence-specific DNA binding
I6J40_RS10970	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6J40_RS10985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J40_RS11000	COG4608	Belongs to the ABC transporter superfamily
I6J40_RS11010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS11015	COG0601	transmembrane transport
I6J40_RS11020	COG4166	transmembrane transport
I6J40_RS11025	COG4608	Belongs to the ABC transporter superfamily
I6J40_RS11035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS11040	COG0601	transmembrane transport
I6J40_RS11050	COG1217	gtp-binding protein TYPA
I6J40_RS11065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J40_RS11120	COG0789	Transcriptional regulator
I6J40_RS11230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J40_RS11240	COG0477	Major facilitator Superfamily
I6J40_RS11250	COG0012	GTP binding
I6J40_RS11265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J40_RS11275	COG1570	exodeoxyribonuclease VII activity
I6J40_RS11280	COG1722	exodeoxyribonuclease VII activity
I6J40_RS11285	COG0778	Nitroreductase
I6J40_RS11310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J40_RS11310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J40_RS11340	COG1362	aminopeptidase activity
I6J40_RS11350	COG0114	fumarate hydratase activity
I6J40_RS11365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J40_RS11365	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J40_RS11385	COG1136	(ABC) transporter
I6J40_RS11400	COG0450	alkyl hydroperoxide reductase
I6J40_RS11405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J40_RS11420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J40_RS11425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J40_RS11430	COG0667	Aldo Keto reductase
I6J40_RS11440	COG2226	methyltransferase
I6J40_RS11505	COG2885	chlorophyll binding
I6J40_RS11525	COG2197	response regulator
I6J40_RS11560	COG2894	cell division
I6J40_RS11585	COG2610	gluconate transmembrane transporter activity
I6J40_RS11590	COG0251	oxidation-reduction process
I6J40_RS11595	COG1414	Transcriptional regulator
I6J40_RS11610	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J40_RS11630	COG1733	regulation of RNA biosynthetic process
I6J40_RS11650	COG0436	Aminotransferase
I6J40_RS11660	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J40_RS11670	COG1331	Highly conserved protein containing a thioredoxin domain
I6J40_RS11695	COG4585	Histidine kinase
I6J40_RS11705	COG1136	(ABC) transporter
I6J40_RS11705	COG0577	efflux transmembrane transporter activity
I6J40_RS11710	COG2197	response regulator
I6J40_RS11755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J40_RS11765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J40_RS11780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J40_RS11790	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J40_RS11795	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J40_RS11800	COG2172	sigma factor antagonist activity
I6J40_RS11810	COG0784	Response regulator, receiver
I6J40_RS11810	COG5002	protein histidine kinase activity
I6J40_RS11810	COG2198	Histidine kinase
I6J40_RS11815	COG0745	RESPONSE REGULATOR receiver
I6J40_RS11820	COG1595	DNA-templated transcription, initiation
I6J40_RS11860	COG0583	DNA-binding transcription factor activity
I6J40_RS11865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J40_RS11880	COG1396	sequence-specific DNA binding
I6J40_RS11890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J40_RS11910	COG1376	ErfK ybiS ycfS ynhG family protein
I6J40_RS11935	COG1024	Enoyl-CoA hydratase
I6J40_RS11950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J40_RS11960	COG0424	maF-like protein
I6J40_RS11970	COG4770	biotin carboxylase activity
I6J40_RS12000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J40_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS12035	COG1595	DNA-templated transcription, initiation
I6J40_RS12040	COG0745	RESPONSE REGULATOR receiver
I6J40_RS12045	COG2205	protein histidine kinase activity
I6J40_RS12070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J40_RS12090	COG0583	DNA-binding transcription factor activity
I6J40_RS12095	COG2814	Major facilitator Superfamily
I6J40_RS12115	COG1404	Belongs to the peptidase S8 family
I6J40_RS12135	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J40_RS12140	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J40_RS12145	COG3845	ABC transporter
I6J40_RS12150	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J40_RS12155	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J40_RS12155	COG1473	amidohydrolase
I6J40_RS12165	COG2089	acid synthase
I6J40_RS12170	COG1083	cytidylyl-transferase
I6J40_RS12180	COG1216	Glycosyl transferase, family 2
I6J40_RS12230	COG1595	DNA-templated transcription, initiation
I6J40_RS12235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J40_RS12275	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J40_RS12280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J40_RS12285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J40_RS12335	COG2009	succinate dehydrogenase
I6J40_RS12345	COG1053	succinate dehydrogenase
I6J40_RS12350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J40_RS12385	COG1408	metallophosphoesterase
I6J40_RS12400	COG1295	ribonuclease BN
I6J40_RS12420	COG0180	Tryptophanyl-tRNA synthetase
I6J40_RS12425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J40_RS12430	COG0754	glutathionylspermidine amidase activity
I6J40_RS12440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J40_RS12445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J40_RS12465	COG0039	L-malate dehydrogenase activity
I6J40_RS12480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J40_RS12495	COG0138	bifunctional purine biosynthesis protein purh
I6J40_RS12525	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J40_RS12530	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J40_RS12540	COG0714	Associated with various cellular activities
I6J40_RS12560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J40_RS12570	COG0739	heme binding
I6J40_RS12590	COG0791	NLP P60 protein
I6J40_RS12595	COG2197	response regulator
I6J40_RS12625	COG4106	trans-aconitate 2-methyltransferase activity
I6J40_RS12635	COG0519	Catalyzes the synthesis of GMP from XMP
I6J40_RS12635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J40_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS12665	COG0515	serine threonine protein kinase
I6J40_RS12700	COG0516	GMP reductase activity
I6J40_RS12710	COG1595	DNA-templated transcription, initiation
I6J40_RS12725	COG0583	DNA-binding transcription factor activity
I6J40_RS12740	COG2132	Multicopper oxidase
I6J40_RS12755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J40_RS12765	COG0726	polysaccharide deacetylase
I6J40_RS12800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J40_RS12825	COG0802	atpase or kinase
I6J40_RS12835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J40_RS12840	COG3189	MarR family transcriptional regulator
I6J40_RS12850	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J40_RS12855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J40_RS12865	COG0596	Alpha beta hydrolase
I6J40_RS12960	COG1072	(Pantothenic acid kinase))
I6J40_RS12970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J40_RS12975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J40_RS12980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J40_RS12985	COG0488	(ABC) transporter
I6J40_RS12995	COG0101	tRNA pseudouridine synthase activity
I6J40_RS13000	COG0203	ribosomal protein L17
I6J40_RS13005	COG0202	RNA polymerase activity
I6J40_RS13010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J40_RS13015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J40_RS13020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J40_RS13025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J40_RS13035	COG0563	adenylate kinase activity
I6J40_RS13045	COG0200	Binds to the 23S rRNA
I6J40_RS13050	COG1841	ribosomal large subunit assembly
I6J40_RS13055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J40_RS13060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J40_RS13065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J40_RS13070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J40_RS13075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J40_RS13080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J40_RS13085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J40_RS13090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J40_RS13095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J40_RS13100	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J40_RS13105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J40_RS13110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J40_RS13115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J40_RS13120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J40_RS13125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J40_RS13130	COG0089	rRNA binding
I6J40_RS13135	COG0088	Forms part of the polypeptide exit tunnel
I6J40_RS13140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J40_RS13145	COG0051	transcription antitermination factor activity, RNA binding
I6J40_RS13155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J40_RS13235	COG2197	response regulator
I6J40_RS13240	COG4585	Histidine kinase
I6J40_RS13245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J40_RS13250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J40_RS13255	COG0049	tRNA binding
I6J40_RS13260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J40_RS13275	COG1196	nuclear chromosome segregation
I6J40_RS13275	COG0739	heme binding
I6J40_RS13275	COG0741	lytic transglycosylase activity
I6J40_RS13355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J40_RS13360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J40_RS13365	COG0085	RNA polymerase activity
I6J40_RS13370	COG0222	ribosome binding
I6J40_RS13375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J40_RS13385	COG0081	regulation of translation
I6J40_RS13390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J40_RS13410	COG0436	Aminotransferase
I6J40_RS13415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J40_RS13420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J40_RS13440	COG2030	dehydratase
I6J40_RS13445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J40_RS13465	COG0702	epimerase
I6J40_RS13475	COG1666	GTP binding
I6J40_RS13480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J40_RS13495	COG3304	Inner membrane component domain
I6J40_RS13500	COG0501	Belongs to the peptidase M48B family
I6J40_RS13505	COG1970	mechanosensitive ion channel activity
I6J40_RS13510	COG1007	ATP synthesis coupled electron transport
I6J40_RS13525	COG0713	ATP synthesis coupled electron transport
I6J40_RS13530	COG0839	Belongs to the complex I subunit 6 family
I6J40_RS13535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J40_RS13545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13550	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J40_RS13570	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J40_RS13575	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J40_RS13580	COG1733	regulation of RNA biosynthetic process
I6J40_RS13585	COG0702	epimerase
I6J40_RS13675	COG0667	Aldo Keto reductase
I6J40_RS13690	COG0561	phosphatase activity
I6J40_RS13720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J40_RS13720	COG0515	serine threonine protein kinase
I6J40_RS13745	COG0142	geranyltranstransferase activity
I6J40_RS13750	COG3104	oligopeptide transport
I6J40_RS13785	COG0514	ATP-dependent DNA helicase (RecQ)
I6J40_RS13790	COG1007	ATP synthesis coupled electron transport
I6J40_RS13800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J40_RS13805	COG0713	ATP synthesis coupled electron transport
I6J40_RS13810	COG0839	Belongs to the complex I subunit 6 family
I6J40_RS13815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J40_RS13825	COG1034	ATP synthesis coupled electron transport
I6J40_RS13830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J40_RS13840	COG0649	NAD binding
I6J40_RS13845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J40_RS13915	COG2226	methyltransferase
I6J40_RS13920	COG2175	clavaminate synthase activity
I6J40_RS13930	COG4521	taurine ABC transporter
I6J40_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J40_RS13960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J40_RS13970	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J40_RS13975	COG1278	Cold shock
I6J40_RS13980	COG0789	Transcriptional regulator
I6J40_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS14025	COG1024	Enoyl-CoA hydratase
I6J40_RS14050	COG1309	transcriptional regulator
I6J40_RS14060	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS14085	COG0501	Belongs to the peptidase M48B family
I6J40_RS14100	COG2124	cytochrome p450
I6J40_RS14115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS14125	COG4592	Periplasmic binding protein
I6J40_RS14130	COG2072	flavoprotein involved in K transport
I6J40_RS14140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J40_RS14165	COG1024	Enoyl-CoA hydratase
I6J40_RS14170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J40_RS14210	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS14215	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS14230	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS14235	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS14245	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS14260	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J40_RS14290	COG0604	alcohol dehydrogenase
I6J40_RS14345	COG4821	SIS domain
I6J40_RS14355	COG0259	pyridoxamine-phosphate oxidase activity
I6J40_RS14375	COG1396	sequence-specific DNA binding
I6J40_RS14415	COG1309	transcriptional regulator
I6J40_RS14420	COG1024	Enoyl-CoA hydratase
I6J40_RS14425	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS14440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J40_RS14455	COG1051	belongs to the nudix hydrolase family
I6J40_RS14465	COG2080	2 iron, 2 sulfur cluster binding
I6J40_RS14465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J40_RS14495	COG5006	permease, DMT superfamily
I6J40_RS14500	COG0583	DNA-binding transcription factor activity
I6J40_RS14505	COG0247	lactate metabolic process
I6J40_RS14505	COG0277	FAD linked oxidase domain protein
I6J40_RS14510	COG2205	protein histidine kinase activity
I6J40_RS14540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J40_RS14550	COG2318	DinB family
I6J40_RS14565	COG1335	isochorismatase
I6J40_RS14630	COG1309	transcriptional regulator
I6J40_RS14650	COG2205	protein histidine kinase activity
I6J40_RS14655	COG0745	RESPONSE REGULATOR receiver
I6J40_RS14675	COG1136	(ABC) transporter
I6J40_RS14675	COG0577	efflux transmembrane transporter activity
I6J40_RS14715	COG2161	toxin-antitoxin pair type II binding
I6J40_RS14735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J40_RS14800	COG2318	DinB family
I6J40_RS14835	COG0113	porphobilinogen synthase activity
I6J40_RS14840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J40_RS14840	COG1648	precorrin-2 dehydrogenase activity
I6J40_RS14845	COG0181	hydroxymethylbilane synthase activity
I6J40_RS14850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J40_RS14855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J40_RS14915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS14935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J40_RS14945	COG0842	Transport permease protein
I6J40_RS14945	COG1129	ABC transporter
I6J40_RS14955	COG4991	sh3 domain protein
I6J40_RS14960	COG0515	serine threonine protein kinase
I6J40_RS14960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J40_RS14965	COG0129	dihydroxy-acid dehydratase activity
I6J40_RS14975	COG1082	Xylose isomerase domain protein TIM barrel
I6J40_RS14980	COG0248	Ppx GppA phosphatase
I6J40_RS15000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6J40_RS15010	COG1194	a g-specific adenine glycosylase
I6J40_RS15015	COG1595	DNA-templated transcription, initiation
I6J40_RS15025	COG0745	RESPONSE REGULATOR receiver
I6J40_RS15030	COG2205	protein histidine kinase activity
I6J40_RS15035	COG0739	heme binding
I6J40_RS15065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J40_RS15085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J40_RS15095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J40_RS15100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J40_RS15125	COG1660	Displays ATPase and GTPase activities
I6J40_RS15130	COG2197	response regulator
I6J40_RS15145	COG0649	NAD binding
I6J40_RS15160	COG1174	glycine betaine transport
I6J40_RS15165	COG1174	glycine betaine transport
I6J40_RS15170	COG1125	glycine betaine transport
I6J40_RS15170	COG0517	IMP dehydrogenase activity
I6J40_RS15180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J40_RS15180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J40_RS15195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J40_RS15215	COG0302	gtp cyclohydrolase
I6J40_RS15230	COG0037	tRNA processing
I6J40_RS15240	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J40_RS15245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J40_RS15255	COG0586	Pfam SNARE associated Golgi protein
I6J40_RS15260	COG0393	Putative heavy-metal-binding
I6J40_RS15270	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J40_RS15275	COG0076	glutamate decarboxylase activity
I6J40_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS15345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J40_RS15345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J40_RS15370	COG1653	transport
I6J40_RS15380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J40_RS15405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J40_RS15435	COG4585	Histidine kinase
I6J40_RS15440	COG2197	response regulator
I6J40_RS15460	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J40_RS15480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J40_RS15525	COG0745	RESPONSE REGULATOR receiver
I6J40_RS15575	COG3311	Transcriptional regulator
I6J40_RS15670	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J40_RS15705	COG3842	ATPase activity
I6J40_RS15730	COG0215	cysteine-tRNA ligase activity
I6J40_RS15735	COG3467	pyridoxamine 5'-phosphate
I6J40_RS15745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J40_RS15760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J40_RS15765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J40_RS15770	COG1329	Transcriptional regulator
I6J40_RS15785	COG5002	protein histidine kinase activity
I6J40_RS15805	COG0588	phosphoglycerate mutase activity
I6J40_RS15810	COG0456	acetyltransferase
I6J40_RS15815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J40_RS15820	COG0798	PFAM Bile acid sodium symporter
I6J40_RS15825	COG0640	Transcriptional regulator
I6J40_RS15870	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS15940	COG4942	peptidase
I6J40_RS15980	COG4552	Acetyltransferase involved in intracellular survival and related
I6J40_RS15995	COG1490	D-aminoacyl-tRNA deacylase activity
I6J40_RS16005	COG0735	belongs to the Fur family
I6J40_RS16010	COG3485	protocatechuate 3,4-dioxygenase
I6J40_RS16030	COG2897	thiosulfate sulfurtransferase activity
I6J40_RS16055	COG0745	RESPONSE REGULATOR receiver
I6J40_RS16060	COG1609	Transcriptional regulator
I6J40_RS16065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J40_RS16100	COG0739	heme binding
I6J40_RS16120	COG4977	sequence-specific DNA binding
I6J40_RS16150	COG2801	Transposase and inactivated derivatives
I6J40_RS16150	COG3415	Transposase
I6J40_RS16175	COG0154	amidase activity
I6J40_RS16185	COG0737	Belongs to the 5'-nucleotidase family
I6J40_RS16195	COG0456	acetyltransferase
I6J40_RS16200	COG1725	Transcriptional regulator
I6J40_RS16205	COG1116	anion transmembrane transporter activity
I6J40_RS16225	COG0494	nUDIX hydrolase
I6J40_RS16225	COG0406	alpha-ribazole phosphatase activity
I6J40_RS16230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J40_RS16250	COG0306	phosphate transporter
I6J40_RS16260	COG1937	Protein conserved in bacteria
I6J40_RS16280	COG0671	phosphoesterase, PA-phosphatase related
I6J40_RS16285	COG0739	heme binding
I6J40_RS16285	COG0741	lytic transglycosylase activity
I6J40_RS16285	COG1196	nuclear chromosome segregation
I6J40_RS16365	COG4585	Histidine kinase
I6J40_RS16370	COG2197	response regulator
I6J40_RS16390	COG1846	Transcriptional regulator
I6J40_RS16405	COG1252	NADH dehydrogenase
I6J40_RS16430	COG0579	oxidoreductase
I6J40_RS16435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J40_RS16450	COG1196	nuclear chromosome segregation
I6J40_RS16450	COG0741	lytic transglycosylase activity
I6J40_RS16450	COG0739	heme binding
I6J40_RS16475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J40_RS16480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J40_RS16485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J40_RS16485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J40_RS16500	COG1937	Protein conserved in bacteria
I6J40_RS16520	COG0513	Belongs to the DEAD box helicase family
I6J40_RS16530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J40_RS16565	COG0785	Cytochrome C biogenesis protein
I6J40_RS16570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J40_RS16570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J40_RS16580	COG1643	Atp-dependent helicase
I6J40_RS16600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J40_RS16610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J40_RS16620	COG3119	arylsulfatase activity
I6J40_RS16635	COG0741	lytic transglycosylase activity
I6J40_RS16635	COG1196	nuclear chromosome segregation
I6J40_RS16635	COG0739	heme binding
I6J40_RS16645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J40_RS16650	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J40_RS16655	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J40_RS16675	COG1131	(ABC) transporter
I6J40_RS16690	COG2197	response regulator
I6J40_RS16700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J40_RS16715	COG0151	Belongs to the GarS family
I6J40_RS16830	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J40_RS16855	COG4941	Belongs to the sigma-70 factor family
I6J40_RS16875	COG2234	aminopeptidase activity
I6J40_RS16890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J40_RS16930	COG1191	sigma factor activity
I6J40_RS16935	COG1191	sigma factor activity
I6J40_RS16960	COG2353	YceI-like domain
I6J40_RS16965	COG3467	pyridoxamine 5'-phosphate
I6J40_RS16980	COG0477	Major facilitator Superfamily
I6J40_RS16990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J40_RS17010	COG0745	RESPONSE REGULATOR receiver
I6J40_RS17030	COG1595	DNA-templated transcription, initiation
I6J40_RS17035	COG1252	NADH dehydrogenase
I6J40_RS17050	COG0494	nUDIX hydrolase
I6J40_RS17075	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS17080	COG1595	DNA-templated transcription, initiation
I6J40_RS17105	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS17130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J40_RS17145	COG0653	protein targeting
I6J40_RS17160	COG0006	proline dipeptidase activity
I6J40_RS17180	COG1999	signal sequence binding
I6J40_RS17190	COG2372	response to copper ion
I6J40_RS17195	COG2837	iron assimilation
I6J40_RS17205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J40_RS17210	COG0561	phosphatase activity
I6J40_RS17235	COG1131	(ABC) transporter
I6J40_RS17250	COG0789	Transcriptional regulator
I6J40_RS17255	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J40_RS17265	COG0561	phosphatase activity
I6J40_RS17275	COG4988	ABC transporter
I6J40_RS17280	COG1294	oxidase, subunit
I6J40_RS17285	COG1271	oxidase subunit
I6J40_RS17290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J40_RS17295	COG1609	Transcriptional regulator
I6J40_RS17300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J40_RS17310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J40_RS17335	COG0662	Cupin 2, conserved barrel domain protein
I6J40_RS17340	COG1950	PFAM Membrane protein of
I6J40_RS17345	COG0626	cystathionine gamma-synthase activity
I6J40_RS17360	COG2814	Major facilitator Superfamily
I6J40_RS17390	COG0305	Participates in initiation and elongation during chromosome replication
I6J40_RS17400	COG0359	binds to the 23S rRNA
I6J40_RS17405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J40_RS17410	COG0629	single-stranded DNA binding
I6J40_RS17415	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J40_RS17440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J40_RS17475	COG0515	serine threonine protein kinase
I6J40_RS17475	COG2815	serine threonine protein kinase
I6J40_RS17480	COG1595	DNA-templated transcription, initiation
I6J40_RS17490	COG0492	ferredoxin-NADP+ reductase activity
I6J40_RS17495	COG3118	belongs to the thioredoxin family
I6J40_RS17510	COG1192	Involved in chromosome partitioning
I6J40_RS17515	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J40_RS17525	COG0706	membrane insertase activity
I6J40_RS17530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J40_RS17535	COG0594	ribonuclease P activity
I6J40_RS17550	COG0592	DNA-directed DNA polymerase activity
I6J40_RS17555	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J40_RS17560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J40_RS17565	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J40_RS17575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J40_RS17605	COG0515	serine threonine protein kinase
I6J40_RS17645	COG3764	Sortase (surface protein transpeptidase)
I6J40_RS17660	COG3764	Sortase (surface protein transpeptidase)
I6J40_RS17665	COG3764	Sortase (surface protein transpeptidase)
I6J40_RS17670	COG0515	serine threonine protein kinase
I6J40_RS17675	COG0768	penicillin binding
I6J40_RS17690	COG1716	ATPase activity
I6J40_RS17695	COG1716	ATPase activity
I6J40_RS17730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J40_RS17735	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J40_RS17740	COG3396	Phenylacetate-CoA oxygenase
I6J40_RS17745	COG3460	Phenylacetate-CoA oxygenase
I6J40_RS17750	COG3396	Phenylacetate-CoA oxygenase
I6J40_RS17775	COG1309	transcriptional regulator
I6J40_RS17780	COG1522	sequence-specific DNA binding
I6J40_RS17830	COG1136	(ABC) transporter
I6J40_RS17830	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J40_RS17845	COG0515	serine threonine protein kinase
I6J40_RS17850	COG0515	serine threonine protein kinase
I6J40_RS17875	COG0022	dehydrogenase e1 component
I6J40_RS17880	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J40_RS17895	COG2271	Major facilitator Superfamily
I6J40_RS17905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J40_RS17930	COG3629	intracellular signal transduction
I6J40_RS17930	COG3903	Transcriptional regulator
I6J40_RS17940	COG1362	aminopeptidase activity
I6J40_RS17950	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS17960	COG1741	Belongs to the pirin family
I6J40_RS17975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J40_RS17990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J40_RS17995	COG0745	RESPONSE REGULATOR receiver
I6J40_RS18000	COG2205	protein histidine kinase activity
I6J40_RS18005	COG2304	oxidoreductase activity
I6J40_RS18030	COG0431	NADPH-dependent FMN reductase
I6J40_RS18065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS18070	COG0180	Tryptophanyl-tRNA synthetase
I6J40_RS18080	COG2255	four-way junction helicase activity
I6J40_RS18105	COG0181	hydroxymethylbilane synthase activity
I6J40_RS18110	COG0475	glutathione-regulated potassium exporter activity
I6J40_RS18115	COG0490	domain, Protein
I6J40_RS18165	COG2268	Band 7 protein
I6J40_RS18175	COG0450	alkyl hydroperoxide reductase
I6J40_RS18225	COG1278	Cold shock
I6J40_RS18230	COG0513	Belongs to the DEAD box helicase family
I6J40_RS18240	COG2409	Drug exporters of the RND superfamily
I6J40_RS18305	COG0745	RESPONSE REGULATOR receiver
I6J40_RS18310	COG2205	protein histidine kinase activity
I6J40_RS18370	COG4585	Histidine kinase
I6J40_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS18405	COG1309	transcriptional regulator
I6J40_RS18470	COG0717	Belongs to the dCTP deaminase family
I6J40_RS18490	COG0247	lactate metabolic process
I6J40_RS18490	COG2181	nitrate reductase activity
I6J40_RS18495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J40_RS18500	COG0443	Heat shock 70 kDa protein
I6J40_RS18505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J40_RS18510	COG0484	heat shock protein binding
I6J40_RS18515	COG0789	Transcriptional regulator
I6J40_RS18555	COG0542	response to heat
I6J40_RS18580	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6J40_RS18595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J40_RS18600	COG0191	fructose-bisphosphate aldolase activity
I6J40_RS18605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J40_RS18610	COG0477	Major facilitator Superfamily
I6J40_RS18625	COG3844	kynureninase activity
I6J40_RS18635	COG0702	epimerase
I6J40_RS18640	COG4585	Histidine kinase
I6J40_RS18645	COG2197	response regulator
I6J40_RS18650	COG2124	cytochrome p450
I6J40_RS18670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J40_RS18700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J40_RS18710	COG0590	tRNA wobble adenosine to inosine editing
I6J40_RS18770	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS18775	COG0662	Cupin 2, conserved barrel domain protein
I6J40_RS18785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS18810	COG0667	Aldo Keto reductase
I6J40_RS18815	COG3226	Transcriptional regulator
I6J40_RS18820	COG0738	Major facilitator superfamily
I6J40_RS18830	COG2124	cytochrome p450
I6J40_RS18840	COG0693	protein deglycase activity
I6J40_RS18845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J40_RS18850	COG1802	Transcriptional regulator
I6J40_RS18865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J40_RS18870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J40_RS18880	COG0702	epimerase
I6J40_RS18905	COG1595	DNA-templated transcription, initiation
I6J40_RS18925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J40_RS18935	COG2755	lipolytic protein G-D-S-L family
I6J40_RS18940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J40_RS18985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J40_RS18995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J40_RS19025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J40_RS19065	COG0017	Asparaginyl-tRNA synthetase
I6J40_RS19120	COG1609	Transcriptional regulator
I6J40_RS19155	COG1408	metallophosphoesterase
I6J40_RS19160	COG1610	YqeY-like protein
I6J40_RS19165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J40_RS19175	COG0003	Pfam Anion-transporting ATPase
I6J40_RS19190	COG0251	oxidation-reduction process
I6J40_RS19200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J40_RS19225	COG2267	carboxylic ester hydrolase activity
I6J40_RS19235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J40_RS19240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J40_RS19300	COG1205	dead DEAH box helicase
I6J40_RS19300	COG1111	helicase
I6J40_RS19305	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J40_RS19315	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J40_RS19325	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J40_RS19335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J40_RS19335	COG1754	DNA topoisomerase type I activity
I6J40_RS19340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J40_RS19345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J40_RS19385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J40_RS19410	COG2197	response regulator
I6J40_RS19420	COG1136	(ABC) transporter
I6J40_RS19420	COG0577	efflux transmembrane transporter activity
I6J40_RS19440	COG1131	(ABC) transporter
I6J40_RS19475	COG2197	response regulator
I6J40_RS19500	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6J40_RS19510	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J40_RS19515	COG0463	Glycosyl transferase, family 2
I6J40_RS19565	COG1132	(ABC) transporter
I6J40_RS19575	COG1595	DNA-templated transcription, initiation
I6J40_RS19620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J40_RS19630	COG2226	methyltransferase
I6J40_RS19655	COG0395	ABC-type sugar transport system, permease component
I6J40_RS19660	COG1175	transmembrane transport
I6J40_RS19695	COG4251	negative regulation of phosphorylation
I6J40_RS19700	COG2204	response regulator
I6J40_RS19725	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J40_RS19770	COG4257	antibiotic catabolic process
I6J40_RS19790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J40_RS19790	COG1263	PTS System
I6J40_RS19795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J40_RS19800	COG1737	Transcriptional regulator
I6J40_RS19820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J40_RS19825	COG0640	Transcriptional regulator
I6J40_RS19830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J40_RS19840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J40_RS19850	COG1984	allophanate hydrolase subunit 2
I6J40_RS19870	COG3973	AAA domain
I6J40_RS19895	COG1120	ATPase activity
I6J40_RS19905	COG1061	Type III restriction enzyme res subunit
I6J40_RS19945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J40_RS19950	COG1120	ATPase activity
I6J40_RS19955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS19960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS19985	COG1278	Cold shock
I6J40_RS19995	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J40_RS20000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J40_RS20010	COG2814	Major facilitator Superfamily
I6J40_RS20030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J40_RS20040	COG2252	PERMEase
I6J40_RS20070	COG1309	transcriptional regulator
I6J40_RS20075	COG0667	Aldo Keto reductase
I6J40_RS20090	COG0671	phosphoesterase, PA-phosphatase related
I6J40_RS20155	COG2267	carboxylic ester hydrolase activity
I6J40_RS20195	COG0515	serine threonine protein kinase
I6J40_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS20205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS20245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J40_RS20280	COG0018	arginyl-trna synthetase
I6J40_RS20285	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6J40_RS20310	COG1690	Belongs to the RtcB family
I6J40_RS20315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J40_RS20355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J40_RS20360	COG0406	alpha-ribazole phosphatase activity
I6J40_RS20370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J40_RS20375	COG0785	Cytochrome C biogenesis protein
I6J40_RS20380	COG1333	cytochrome c biogenesis protein
I6J40_RS20385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J40_RS20395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J40_RS20410	COG0163	prenyltransferase activity
I6J40_RS20420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J40_RS20430	COG1301	dicarboxylic acid transport
I6J40_RS20440	COG1309	transcriptional regulator
I6J40_RS20460	COG2208	phosphoserine phosphatase activity
I6J40_RS20460	COG2770	Histidine kinase
I6J40_RS20475	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS20480	COG0183	Belongs to the thiolase family
I6J40_RS20505	COG0741	lytic transglycosylase activity
I6J40_RS20505	COG1196	nuclear chromosome segregation
I6J40_RS20505	COG0739	heme binding
I6J40_RS20620	COG0768	penicillin binding
I6J40_RS20625	COG3386	PFAM SMP-30 Gluconolaconase
I6J40_RS20640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J40_RS20735	COG1686	Belongs to the peptidase S11 family
I6J40_RS20765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS20770	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS20795	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS20815	COG1846	Transcriptional regulator
I6J40_RS20820	COG3384	dioxygenase
I6J40_RS20840	COG0477	Major facilitator Superfamily
I6J40_RS20860	COG0243	molybdopterin cofactor binding
I6J40_RS20865	COG0437	4 iron, 4 sulfur cluster binding
I6J40_RS20890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J40_RS20905	COG3263	regulation of cellular component size
I6J40_RS20915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J40_RS20920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J40_RS20930	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J40_RS20935	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J40_RS20970	COG2340	Cysteine-rich secretory protein family
I6J40_RS21000	COG0708	Exodeoxyribonuclease III
I6J40_RS21010	COG2072	flavoprotein involved in K transport
I6J40_RS21020	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS21030	COG4946	Tricorn protease homolog
I6J40_RS21030	COG0793	Belongs to the peptidase S41A family
I6J40_RS21040	COG2409	Drug exporters of the RND superfamily
I6J40_RS21050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J40_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS21075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J40_RS21080	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I6J40_RS21100	COG0442	prolyl-tRNA aminoacylation
I6J40_RS21105	COG2207	Transcriptional regulator
I6J40_RS21110	COG2223	nitrite transmembrane transporter activity
I6J40_RS21160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J40_RS21190	COG0084	hydrolase, TatD family'
I6J40_RS21195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J40_RS21200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J40_RS21215	COG4115	mRNA cleavage
I6J40_RS21220	COG2161	toxin-antitoxin pair type II binding
I6J40_RS21240	COG0488	(ABC) transporter
I6J40_RS21265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J40_RS21280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J40_RS21290	COG2197	response regulator
I6J40_RS21295	COG1846	Transcriptional regulator
I6J40_RS21300	COG4106	trans-aconitate 2-methyltransferase activity
I6J40_RS21325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J40_RS21330	COG0193	aminoacyl-tRNA hydrolase activity
I6J40_RS21335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J40_RS21340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J40_RS21345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J40_RS21355	COG4585	Histidine kinase
I6J40_RS21385	COG2124	cytochrome p450
I6J40_RS21430	COG0346	lactoylglutathione lyase activity
I6J40_RS21435	COG0477	Major facilitator Superfamily
I6J40_RS21440	COG1136	(ABC) transporter
I6J40_RS21445	COG0577	efflux transmembrane transporter activity
I6J40_RS21455	COG3629	intracellular signal transduction
I6J40_RS21455	COG3903	Transcriptional regulator
I6J40_RS21510	COG1473	amidohydrolase
I6J40_RS21565	COG1335	isochorismatase
I6J40_RS21585	COG2815	serine threonine protein kinase
I6J40_RS21585	COG0515	serine threonine protein kinase
I6J40_RS21610	COG1652	LysM domain
I6J40_RS21620	COG0148	phosphopyruvate hydratase activity
I6J40_RS21640	COG1252	NADH dehydrogenase
I6J40_RS21645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J40_RS21650	COG1136	(ABC) transporter
I6J40_RS21650	COG0577	efflux transmembrane transporter activity
I6J40_RS21655	COG1136	(ABC) transporter
I6J40_RS21655	COG0577	efflux transmembrane transporter activity
I6J40_RS21680	COG0183	Belongs to the thiolase family
I6J40_RS21685	COG2755	lipolytic protein G-D-S-L family
I6J40_RS21725	COG0531	amino acid
I6J40_RS21730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J40_RS21735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J40_RS21745	COG1228	amidohydrolase
I6J40_RS21750	COG1191	sigma factor activity
I6J40_RS21755	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J40_RS21785	COG3104	oligopeptide transport
I6J40_RS21790	COG0745	RESPONSE REGULATOR receiver
I6J40_RS21795	COG2205	protein histidine kinase activity
I6J40_RS21825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J40_RS21900	COG1316	TRANSCRIPTIONal
I6J40_RS21910	COG1316	TRANSCRIPTIONal
I6J40_RS21920	COG1316	TRANSCRIPTIONal
I6J40_RS21925	COG1316	TRANSCRIPTIONal
I6J40_RS21950	COG0531	amino acid
I6J40_RS21955	COG0778	Nitroreductase
I6J40_RS21955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J40_RS21960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J40_RS21995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J40_RS22000	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J40_RS22020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J40_RS22060	COG0714	Associated with various cellular activities
I6J40_RS22080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J40_RS22085	COG0745	RESPONSE REGULATOR receiver
I6J40_RS22090	COG5000	phosphorelay sensor kinase activity
I6J40_RS22090	COG5002	protein histidine kinase activity
I6J40_RS22095	COG0823	Involved in the tonB-independent uptake of proteins
I6J40_RS22105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J40_RS22110	COG2197	response regulator
I6J40_RS22125	COG0653	protein targeting
I6J40_RS22145	COG2902	Dehydrogenase
I6J40_RS22150	COG1134	teichoic acid transport
I6J40_RS22170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J40_RS22175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J40_RS22180	COG1073	alpha beta
I6J40_RS22180	COG2226	methyltransferase
I6J40_RS22185	COG4122	O-methyltransferase activity
I6J40_RS22190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J40_RS22195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J40_RS22200	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS22205	COG1216	Glycosyl transferase, family 2
I6J40_RS22205	COG1442	glycosyl transferase family 8
I6J40_RS22210	COG0395	ABC-type sugar transport system, permease component
I6J40_RS22215	COG1175	transmembrane transport
I6J40_RS22220	COG1653	transport
I6J40_RS22535	COG0515	serine threonine protein kinase
I6J40_RS22540	COG0515	serine threonine protein kinase
I6J40_RS22545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J40_RS22560	COG2884	Cell division ATP-binding protein ftsE
I6J40_RS22565	COG2177	Part of the ABC transporter FtsEX involved in
I6J40_RS22570	COG0793	Belongs to the peptidase S41A family
I6J40_RS22575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J40_RS22620	COG0583	DNA-binding transcription factor activity
I6J40_RS22625	COG2223	nitrite transmembrane transporter activity
I6J40_RS22650	COG3973	AAA domain
I6J40_RS22650	COG3973	AAA domain
I6J40_RS22660	COG0776	regulation of translation
I6J40_RS22665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J40_RS22670	COG1678	Uncharacterized ACR, COG1678
I6J40_RS22680	COG2182	Extracellular solute-binding protein
I6J40_RS22690	COG0395	ABC-type sugar transport system, permease component
I6J40_RS22695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J40_RS22740	COG3654	unkown
I6J40_RS22745	COG1061	Type III restriction enzyme res subunit
I6J40_RS22770	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J40_RS22790	COG1732	Glycine betaine
I6J40_RS22795	COG1174	glycine betaine transport
I6J40_RS22800	COG1125	glycine betaine transport
I6J40_RS22800	COG0517	IMP dehydrogenase activity
I6J40_RS22805	COG1174	glycine betaine transport
I6J40_RS22815	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J40_RS22825	COG0277	FAD linked oxidase domain protein
I6J40_RS22860	COG1335	isochorismatase
I6J40_RS22870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J40_RS22880	COG1113	amino acid transport
I6J40_RS22895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS22920	COG1234	tRNA 3'-trailer cleavage
I6J40_RS22930	COG1263	PTS System
I6J40_RS22935	COG1263	PTS System
I6J40_RS22940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J40_RS22945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J40_RS22955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J40_RS22975	COG0477	Major facilitator Superfamily
I6J40_RS23000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J40_RS23015	COG4555	ABC transporter
I6J40_RS23030	COG2733	membrane
I6J40_RS23040	COG0596	Alpha beta hydrolase
I6J40_RS23050	COG2175	clavaminate synthase activity
I6J40_RS23065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J40_RS23070	COG3135	benzoate transporter
I6J40_RS23100	COG3655	Transcriptional regulator
I6J40_RS23130	COG1074	ATP-dependent DNA helicase activity
I6J40_RS23160	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J40_RS23190	COG3764	Sortase (surface protein transpeptidase)
I6J40_RS23200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J40_RS23210	COG0706	membrane insertase activity
I6J40_RS23215	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J40_RS23220	COG4702	Belongs to the UPF0303 family
I6J40_RS23225	COG0673	inositol 2-dehydrogenase activity
I6J40_RS23230	COG1940	carbohydrate kinase activity
I6J40_RS23240	COG2188	Transcriptional regulator
I6J40_RS23245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J40_RS23310	COG3397	chitin binding
I6J40_RS23320	COG1414	Transcriptional regulator
I6J40_RS23325	COG1126	abc transporter atp-binding protein
I6J40_RS23330	COG0765	amino acid transport
I6J40_RS23335	COG0765	amino acid transport
I6J40_RS23340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS23350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J40_RS23360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS23435	COG0745	RESPONSE REGULATOR receiver
I6J40_RS23465	COG0395	ABC-type sugar transport system, permease component
I6J40_RS23500	COG4977	sequence-specific DNA binding
I6J40_RS23510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J40_RS23535	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J40_RS23540	COG0076	glutamate decarboxylase activity
I6J40_RS23560	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS23575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J40_RS23580	COG1309	transcriptional regulator
I6J40_RS23610	COG1946	Acyl-CoA thioesterase
I6J40_RS23635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J40_RS23650	COG4106	trans-aconitate 2-methyltransferase activity
I6J40_RS23670	COG0028	Belongs to the TPP enzyme family
I6J40_RS23700	COG0477	Major facilitator Superfamily
I6J40_RS23715	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J40_RS23740	COG1404	Belongs to the peptidase S8 family
I6J40_RS23810	COG1609	Transcriptional regulator
I6J40_RS23815	COG0673	inositol 2-dehydrogenase activity
I6J40_RS23865	COG0596	Alpha beta hydrolase
I6J40_RS23890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J40_RS23930	COG2318	DinB family
I6J40_RS23940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J40_RS23950	COG3718	enzyme involved in inositol metabolism
I6J40_RS23955	COG3962	Belongs to the TPP enzyme family
I6J40_RS23975	COG4585	Histidine kinase
I6J40_RS23980	COG2197	response regulator
I6J40_RS23990	COG1131	(ABC) transporter
I6J40_RS24055	COG0629	single-stranded DNA binding
I6J40_RS24080	COG1136	(ABC) transporter
I6J40_RS24080	COG0577	efflux transmembrane transporter activity
I6J40_RS24100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J40_RS24130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS24145	COG1486	melibiose metabolic process
I6J40_RS24150	COG0395	ABC-type sugar transport system, permease component
I6J40_RS24155	COG1175	transmembrane transport
I6J40_RS24185	COG0668	transmembrane transport
I6J40_RS24195	COG3291	Pkd domain containing protein
I6J40_RS24195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J40_RS24215	COG0583	DNA-binding transcription factor activity
I6J40_RS24220	COG4266	Belongs to the allantoicase family
I6J40_RS24265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J40_RS24275	COG2252	PERMEase
I6J40_RS24290	COG1404	Belongs to the peptidase S8 family
I6J40_RS24295	COG0110	maltose O-acetyltransferase activity
I6J40_RS24310	COG0640	Transcriptional regulator
I6J40_RS24315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J40_RS24325	COG0783	Belongs to the Dps family
I6J40_RS24330	COG0584	glycerophosphoryl diester phosphodiesterase
I6J40_RS24335	COG1113	amino acid transport
I6J40_RS24340	COG1113	amino acid transport
I6J40_RS24345	COG1268	BioY protein
I6J40_RS24355	COG1113	amino acid transport
I6J40_RS24375	COG0475	glutathione-regulated potassium exporter activity
I6J40_RS24385	COG3594	Acyltransferase
I6J40_RS24405	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J40_RS24410	COG0740	serine-type endopeptidase activity
I6J40_RS24415	COG0740	serine-type endopeptidase activity
I6J40_RS24420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J40_RS24430	COG0525	valine-tRNA ligase activity
I6J40_RS24435	COG0285	dihydrofolate synthase activity
I6J40_RS24445	COG0105	UTP biosynthetic process
I6J40_RS24450	COG1077	Cell shape determining protein MreB Mrl
I6J40_RS24465	COG0768	penicillin binding
I6J40_RS24470	COG0772	Belongs to the SEDS family
I6J40_RS24495	COG1530	ribonuclease E activity
I6J40_RS24500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J40_RS24505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J40_RS24510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J40_RS24535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J40_RS24545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J40_RS24560	COG0501	Belongs to the peptidase M48B family
I6J40_RS24575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J40_RS24585	COG0799	negative regulation of ribosome biogenesis
I6J40_RS24590	COG0588	phosphoglycerate mutase activity
I6J40_RS24610	COG0495	leucyl-tRNA aminoacylation
I6J40_RS24620	COG1307	EDD domain protein, DegV family
I6J40_RS24625	COG1555	photosystem II stabilization
I6J40_RS24655	COG0268	Binds directly to 16S ribosomal RNA
I6J40_RS24660	COG0481	GTPase activity
I6J40_RS24700	COG1420	regulation of RNA biosynthetic process
I6J40_RS24705	COG0484	heat shock protein binding
I6J40_RS24720	COG0537	adenosine 5'-monophosphoramidase activity
I6J40_RS24725	COG1234	tRNA 3'-trailer cleavage
I6J40_RS24730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J40_RS24740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J40_RS24740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J40_RS24750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J40_RS24760	COG2315	Protein conserved in bacteria
I6J40_RS24775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J40_RS24790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J40_RS24800	COG1381	Involved in DNA repair and RecF pathway recombination
I6J40_RS24805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J40_RS24815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J40_RS24820	COG1121	(ABC) transporter
I6J40_RS24830	COG0423	glycine-tRNA ligase activity
I6J40_RS24840	COG3104	oligopeptide transport
I6J40_RS24855	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS24860	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS24865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS24870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS24875	COG0662	Cupin 2, conserved barrel domain protein
I6J40_RS24885	COG0367	asparagine synthase
I6J40_RS24910	COG2345	Transcriptional regulator
I6J40_RS24915	COG0477	Major facilitator Superfamily
I6J40_RS24950	COG2124	cytochrome p450
I6J40_RS24955	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS24960	COG0277	FAD linked oxidase domain protein
I6J40_RS24975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J40_RS25155	COG2066	Belongs to the glutaminase family
I6J40_RS25160	COG0477	Major facilitator Superfamily
I6J40_RS25190	COG2188	Transcriptional regulator
I6J40_RS25210	COG3842	ATPase activity
I6J40_RS25215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS25220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J40_RS25220	COG0574	Belongs to the PEP-utilizing enzyme family
I6J40_RS25245	COG2146	nitrite reductase [NAD(P)H] activity
I6J40_RS25245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J40_RS25290	COG2949	membrane
I6J40_RS25300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J40_RS25310	COG0358	DNA primase activity
I6J40_RS25315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J40_RS25330	COG1070	Carbohydrate kinase
I6J40_RS25380	COG0477	Major facilitator Superfamily
I6J40_RS25385	COG0825	malonyl-CoA metabolic process
I6J40_RS25385	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J40_RS25390	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS25400	COG1522	sequence-specific DNA binding
I6J40_RS25430	COG2130	NADP-dependent
I6J40_RS25435	COG1764	response to oxidative stress
I6J40_RS25465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS25470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS25475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J40_RS25520	COG1741	Belongs to the pirin family
I6J40_RS25530	COG0456	acetyltransferase
I6J40_RS25535	COG2957	Belongs to the agmatine deiminase family
I6J40_RS25600	COG1404	Belongs to the peptidase S8 family
I6J40_RS25605	COG1674	ftsk spoiiie
I6J40_RS25680	COG1929	Belongs to the glycerate kinase type-1 family
I6J40_RS25690	COG0667	Aldo Keto reductase
I6J40_RS25700	COG0745	RESPONSE REGULATOR receiver
I6J40_RS25705	COG2205	protein histidine kinase activity
I6J40_RS25715	COG0789	Transcriptional regulator
I6J40_RS25720	COG0667	Aldo Keto reductase
I6J40_RS25735	COG2197	response regulator
I6J40_RS25740	COG4585	Histidine kinase
I6J40_RS25755	COG1309	transcriptional regulator
I6J40_RS25760	COG0477	Major facilitator Superfamily
I6J40_RS25770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J40_RS25815	COG1358	cellular component organization or biogenesis
I6J40_RS25895	COG2259	Doxx family
I6J40_RS25940	COG2124	cytochrome p450
I6J40_RS25945	COG0183	Belongs to the thiolase family
I6J40_RS25965	COG3845	ABC transporter
I6J40_RS26025	COG1309	transcriptional regulator
I6J40_RS26030	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS26055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS26075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J40_RS26080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J40_RS26095	COG3340	Belongs to the peptidase S51 family
I6J40_RS26105	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS26110	COG0183	Belongs to the thiolase family
I6J40_RS26115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J40_RS26125	COG2030	dehydratase
I6J40_RS26135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS26150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J40_RS26155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J40_RS26170	COG0800	Aldolase
I6J40_RS26175	COG3022	response to hydroperoxide
I6J40_RS26200	COG2273	Hydrolase Family 16
I6J40_RS26240	COG0384	phenazine biosynthesis protein PhzF
I6J40_RS26250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS26255	COG3540	Alkaline phosphatase
I6J40_RS26265	COG2814	Major facilitator Superfamily
I6J40_RS26280	COG1834	amidinotransferase
I6J40_RS26300	COG1120	ATPase activity
I6J40_RS26305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS26365	COG1994	Peptidase M50
I6J40_RS26385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J40_RS26390	COG0477	Major facilitator Superfamily
I6J40_RS26405	COG2814	Major facilitator Superfamily
I6J40_RS26410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J40_RS26410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J40_RS26415	COG2132	Multicopper oxidase
I6J40_RS26430	COG0174	glutamine synthetase
I6J40_RS26470	COG0477	Major facilitator Superfamily
I6J40_RS26475	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J40_RS26480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J40_RS26505	COG1609	Transcriptional regulator
I6J40_RS26510	COG2182	Extracellular solute-binding protein
I6J40_RS26520	COG0395	ABC-type sugar transport system, permease component
I6J40_RS26525	COG0366	Alpha amylase catalytic
I6J40_RS26585	COG2197	response regulator
I6J40_RS26590	COG4585	Histidine kinase
I6J40_RS26595	COG2409	Drug exporters of the RND superfamily
I6J40_RS26600	COG0745	RESPONSE REGULATOR receiver
I6J40_RS26620	COG0673	inositol 2-dehydrogenase activity
I6J40_RS26625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J40_RS26650	COG2362	D-Aminopeptidase
I6J40_RS26655	COG3896	Chloramphenicol phosphotransferase-like protein
I6J40_RS26660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J40_RS26685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J40_RS26690	COG0321	lipoyl(octanoyl) transferase activity
I6J40_RS26705	COG1090	epimerase
I6J40_RS26725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J40_RS26735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J40_RS26740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J40_RS26745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J40_RS26750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J40_RS26780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J40_RS26805	COG4585	Histidine kinase
I6J40_RS26810	COG2197	response regulator
I6J40_RS26815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J40_RS26825	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J40_RS26845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J40_RS26855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J40_RS26860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J40_RS26870	COG1376	ErfK ybiS ycfS ynhG family protein
I6J40_RS26880	COG1845	cytochrome c oxidase, subunit III
I6J40_RS26885	COG2010	Cytochrome c
I6J40_RS26890	COG0723	plastoquinol--plastocyanin reductase activity
I6J40_RS26895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J40_RS26900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J40_RS26905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J40_RS26970	COG0003	Pfam Anion-transporting ATPase
I6J40_RS26980	COG1940	carbohydrate kinase activity
I6J40_RS27010	COG2197	response regulator
I6J40_RS27015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J40_RS27030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J40_RS27040	COG2193	ferroxidase activity
I6J40_RS27045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J40_RS27050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J40_RS27055	COG2815	serine threonine protein kinase
I6J40_RS27055	COG0515	serine threonine protein kinase
I6J40_RS27060	COG2022	thiamine diphosphate biosynthetic process
I6J40_RS27070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J40_RS27070	COG2022	thiamine diphosphate biosynthetic process
I6J40_RS27090	COG0352	thiamine-phosphate diphosphorylase activity
I6J40_RS27105	COG1233	COG1233 Phytoene dehydrogenase and related
I6J40_RS27125	COG1129	ABC transporter
I6J40_RS27135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J40_RS27155	COG0714	Associated with various cellular activities
I6J40_RS27165	COG0275	rRNA processing
I6J40_RS27175	COG0768	penicillin binding
I6J40_RS27180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J40_RS27190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J40_RS27195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J40_RS27205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J40_RS27225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J40_RS27230	COG1799	cell septum assembly
I6J40_RS27240	COG3599	regulation of cell shape
I6J40_RS27245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J40_RS27255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J40_RS27300	COG0587	DNA-directed DNA polymerase activity
I6J40_RS27310	COG1432	Conserved Protein
I6J40_RS27330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J40_RS27350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J40_RS27355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J40_RS27360	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J40_RS27370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J40_RS27375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J40_RS27380	COG0251	oxidation-reduction process
I6J40_RS27385	COG0107	imidazoleglycerol-phosphate synthase activity
I6J40_RS27405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J40_RS27410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J40_RS27430	COG0134	indole-3-glycerol-phosphate synthase activity
I6J40_RS27440	COG0133	tryptophan synthase activity
I6J40_RS27445	COG0159	tryptophan synthase activity
I6J40_RS27455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J40_RS27465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J40_RS27470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J40_RS27500	COG0070	glutamate synthase
I6J40_RS27500	COG0069	glutamate synthase activity
I6J40_RS27500	COG0067	glutamate synthase
I6J40_RS27510	COG0705	Rhomboid family
I6J40_RS27530	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS27535	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS27540	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS27545	COG1309	transcriptional regulator
I6J40_RS27550	COG0183	Belongs to the thiolase family
I6J40_RS27555	COG1278	Cold shock
I6J40_RS27580	COG1024	Enoyl-CoA hydratase
I6J40_RS27585	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS27620	COG0287	Prephenate dehydrogenase
I6J40_RS27620	COG1605	Chorismate mutase
I6J40_RS27655	COG0737	Belongs to the 5'-nucleotidase family
I6J40_RS27700	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J40_RS27710	COG2050	protein possibly involved in aromatic compounds catabolism
I6J40_RS27745	COG1643	Atp-dependent helicase
I6J40_RS27750	COG2226	methyltransferase
I6J40_RS27770	COG0237	dephospho-CoA kinase activity
I6J40_RS27785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J40_RS27795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J40_RS27815	COG0436	Aminotransferase
I6J40_RS27835	COG2313	pseudouridylate synthase activity
I6J40_RS27845	COG2814	Major facilitator Superfamily
I6J40_RS27855	COG0584	glycerophosphoryl diester phosphodiesterase
I6J40_RS27865	COG0556	nucleotide-excision repair
I6J40_RS27895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J40_RS27920	COG0322	excinuclease ABC activity
I6J40_RS27925	COG1660	Displays ATPase and GTPase activities
I6J40_RS27930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J40_RS27935	COG1481	regulation of sporulation
I6J40_RS27940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J40_RS27945	COG0126	phosphoglycerate kinase activity
I6J40_RS27950	COG0149	triose-phosphate isomerase activity
I6J40_RS27955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J40_RS27965	COG0166	Belongs to the GPI family
I6J40_RS27980	COG4195	phage-related replication protein
I6J40_RS27990	COG0363	glucosamine-6-phosphate deaminase activity
I6J40_RS28005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J40_RS28015	COG0109	protoheme IX farnesyltransferase activity
I6J40_RS28050	COG0719	Fe-S assembly protein
I6J40_RS28060	COG0396	ATPase activity
I6J40_RS28065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J40_RS28070	COG0822	iron-sulfur transferase activity
I6J40_RS28075	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J40_RS28090	COG3226	Transcriptional regulator
I6J40_RS28095	COG2171	N-acyltransferase activity
I6J40_RS28100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J40_RS28140	COG0768	penicillin binding
I6J40_RS28145	COG2197	response regulator
I6J40_RS28200	COG1902	pentaerythritol trinitrate reductase activity
I6J40_RS28230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J40_RS28255	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J40_RS28270	COG1492	cobalamin metabolic process
I6J40_RS28275	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J40_RS28290	COG0235	Class ii aldolase
I6J40_RS28315	COG0488	(ABC) transporter
I6J40_RS28325	COG1024	Enoyl-CoA hydratase
I6J40_RS28365	COG3387	PFAM Glycoside hydrolase 15-related
I6J40_RS28405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J40_RS28410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J40_RS28425	COG2261	transglycosylase associated protein
I6J40_RS28430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J40_RS28455	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS28460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J40_RS28490	COG0560	Phosphoserine phosphatase
I6J40_RS28490	COG3830	Belongs to the UPF0237 family
I6J40_RS28495	COG0842	Transport permease protein
I6J40_RS28495	COG1131	(ABC) transporter
I6J40_RS28495	COG1716	ATPase activity
I6J40_RS28505	COG4585	Histidine kinase
I6J40_RS28510	COG2197	response regulator
I6J40_RS28520	COG1119	ATPase activity
I6J40_RS28545	COG1881	PFAM PEBP family protein
I6J40_RS28555	COG2094	Belongs to the DNA glycosylase MPG family
I6J40_RS28590	COG0647	UMP catabolic process
I6J40_RS28595	COG1120	ATPase activity
I6J40_RS28615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J40_RS28620	COG0497	DNA recombination
I6J40_RS28645	COG3387	PFAM Glycoside hydrolase 15-related
I6J40_RS28650	COG0504	CTP synthase activity
I6J40_RS28655	COG0494	nUDIX hydrolase
I6J40_RS28665	COG0686	Belongs to the AlaDH PNT family
I6J40_RS28680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J40_RS28685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J40_RS28690	COG1187	pseudouridine synthase activity
I6J40_RS28705	COG0494	nUDIX hydrolase
I6J40_RS28730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J40_RS28740	COG1160	GTP binding
I6J40_RS28755	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS28770	COG0671	phosphoesterase, PA-phosphatase related
I6J40_RS28775	COG0477	Major facilitator Superfamily
I6J40_RS28780	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS28785	COG1799	cell septum assembly
I6J40_RS28795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS28800	COG0765	amino acid transport
I6J40_RS28815	COG1126	abc transporter atp-binding protein
I6J40_RS28820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J40_RS28825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS28830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS28865	COG0641	radical SAM
I6J40_RS28885	COG2197	response regulator
I6J40_RS28890	COG4585	Histidine kinase
I6J40_RS28925	COG4565	transcriptional regulatory protein
I6J40_RS28945	COG0346	lactoylglutathione lyase activity
I6J40_RS28960	COG1725	Transcriptional regulator
I6J40_RS28970	COG2755	lipolytic protein G-D-S-L family
I6J40_RS28980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J40_RS28990	COG2188	Transcriptional regulator
I6J40_RS28995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6J40_RS29015	COG1309	transcriptional regulator
I6J40_RS29020	COG2851	Citrate transporter
I6J40_RS29030	COG2318	DinB family
I6J40_RS29040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J40_RS29055	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS29090	COG3876	Protein conserved in bacteria
I6J40_RS29095	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS29100	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS29110	COG2234	aminopeptidase activity
I6J40_RS29110	COG4935	Belongs to the peptidase S8 family
I6J40_RS29115	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS29135	COG2149	membrane
I6J40_RS29140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J40_RS29170	COG3265	gluconokinase activity
I6J40_RS29175	COG2186	Transcriptional regulator
I6J40_RS29190	COG0564	pseudouridine synthase activity
I6J40_RS29200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J40_RS29230	COG0667	Aldo Keto reductase
I6J40_RS29235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS29245	COG0598	Magnesium transport protein CorA
I6J40_RS29265	COG0215	cysteine-tRNA ligase activity
I6J40_RS29275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS29280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J40_RS29285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J40_RS29290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J40_RS29295	COG1414	Transcriptional regulator
I6J40_RS29300	COG1410	methionine synthase
I6J40_RS29300	COG0646	methionine synthase
I6J40_RS29305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS29310	COG4166	transmembrane transport
I6J40_RS29315	COG2197	response regulator
I6J40_RS29325	COG0517	IMP dehydrogenase activity
I6J40_RS29325	COG1994	Peptidase M50
I6J40_RS29345	COG1222	aaa ATPase
I6J40_RS29350	COG4122	O-methyltransferase activity
I6J40_RS29360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J40_RS29365	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J40_RS29370	COG1609	Transcriptional regulator
I6J40_RS29380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J40_RS29385	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J40_RS29395	COG2378	regulation of single-species biofilm formation
I6J40_RS29415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J40_RS29420	COG0805	protein transport
I6J40_RS29460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J40_RS29465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J40_RS29495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J40_RS29500	COG0517	IMP dehydrogenase activity
I6J40_RS29500	COG4175	Glycine betaine
I6J40_RS29555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J40_RS29565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J40_RS29570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J40_RS29575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J40_RS29580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J40_RS29585	COG5002	protein histidine kinase activity
I6J40_RS29590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J40_RS29595	COG0072	phenylalanine-tRNA ligase activity
I6J40_RS29595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J40_RS29620	COG1649	PFAM Uncharacterised BCR, COG1649
I6J40_RS29630	COG0697	spore germination
I6J40_RS29690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J40_RS29695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J40_RS29700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J40_RS29705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J40_RS29710	COG1438	arginine binding
I6J40_RS29725	COG0137	argininosuccinate synthase activity
I6J40_RS29730	COG0165	Argininosuccinate lyase
I6J40_RS29740	COG3973	AAA domain
I6J40_RS29750	COG0477	Major facilitator Superfamily
I6J40_RS29790	COG2011	ABC-type metal ion transport system permease component
I6J40_RS29795	COG1464	Belongs to the NlpA lipoprotein family
I6J40_RS29810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J40_RS29815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J40_RS29815	COG1648	precorrin-2 dehydrogenase activity
I6J40_RS29870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J40_RS29930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J40_RS29945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J40_RS29965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J40_RS29970	COG1560	Kdo2-lipid A biosynthetic process
I6J40_RS29975	COG0438	transferase activity, transferring glycosyl groups
I6J40_RS29985	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J40_RS29990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J40_RS29995	COG0217	transcriptional regulatory protein
I6J40_RS30005	COG0632	four-way junction helicase activity
I6J40_RS30010	COG2255	four-way junction helicase activity
I6J40_RS30020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J40_RS30025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J40_RS30030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J40_RS30035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J40_RS30055	COG1196	nuclear chromosome segregation
I6J40_RS30070	COG0124	histidyl-tRNA synthetase
I6J40_RS30090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J40_RS30110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J40_RS30115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J40_RS30125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J40_RS30130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J40_RS30135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J40_RS30140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J40_RS30150	COG0006	proline dipeptidase activity
I6J40_RS30155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J40_RS30160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J40_RS30170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J40_RS30175	COG0540	Belongs to the ATCase OTCase family
I6J40_RS30180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J40_RS30190	COG0505	Belongs to the CarA family
I6J40_RS30195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J40_RS30200	COG0167	dihydroorotate dehydrogenase activity
I6J40_RS30205	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J40_RS30220	COG1758	RNA polymerase activity
I6J40_RS30230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J40_RS30245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J40_RS30255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J40_RS30260	COG2390	Transcriptional regulator
I6J40_RS30275	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS30285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J40_RS30300	COG0142	geranyltranstransferase activity
I6J40_RS30320	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J40_RS30335	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS30345	COG2233	PERMEase
I6J40_RS30350	COG0738	Major facilitator superfamily
I6J40_RS30375	COG3201	nicotinamide mononucleotide transporter
I6J40_RS30380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J40_RS30380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J40_RS30385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J40_RS30390	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J40_RS30395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J40_RS30430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J40_RS30440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J40_RS30450	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS30455	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS30475	COG1216	Glycosyl transferase, family 2
I6J40_RS30490	COG2270	Major facilitator Superfamily
I6J40_RS30500	COG2364	Membrane
I6J40_RS30565	COG2018	Roadblock/LC7 domain
I6J40_RS30595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J40_RS30610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J40_RS30620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J40_RS30650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J40_RS30670	COG1716	ATPase activity
I6J40_RS30690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J40_RS30700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J40_RS30700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J40_RS30730	COG0384	phenazine biosynthesis protein PhzF
I6J40_RS30780	COG1595	DNA-templated transcription, initiation
I6J40_RS30805	COG1695	Transcriptional regulator
I6J40_RS30905	COG3800	Transcriptional regulator
I6J40_RS30905	COG1396	sequence-specific DNA binding
I6J40_RS30925	COG1215	transferase activity, transferring glycosyl groups
I6J40_RS30935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J40_RS30945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J40_RS30950	COG4251	negative regulation of phosphorylation
I6J40_RS30955	COG0784	Response regulator, receiver
I6J40_RS30965	COG0477	Major facilitator Superfamily
I6J40_RS31000	COG0069	glutamate synthase activity
I6J40_RS31055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J40_RS31120	COG2226	methyltransferase
I6J40_RS31125	COG0243	molybdopterin cofactor binding
I6J40_RS31145	COG1968	undecaprenyl-diphosphatase activity
I6J40_RS31165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J40_RS31205	COG1832	CoA-binding protein
I6J40_RS31210	COG1739	Uncharacterized protein family UPF0029
I6J40_RS31215	COG0420	3'-5' exonuclease activity
I6J40_RS31220	COG0419	ATPase involved in DNA repair
I6J40_RS31240	COG0626	cystathionine gamma-synthase activity
I6J40_RS31265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J40_RS31280	COG1595	DNA-templated transcription, initiation
I6J40_RS31285	COG2188	Transcriptional regulator
I6J40_RS31290	COG1940	carbohydrate kinase activity
I6J40_RS31300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J40_RS31340	COG2226	methyltransferase
I6J40_RS31345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J40_RS31350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J40_RS31355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J40_RS31360	COG0156	8-amino-7-oxononanoate synthase activity
I6J40_RS31380	COG0583	DNA-binding transcription factor activity
I6J40_RS31385	COG1280	lysine exporter protein (LysE YggA)
I6J40_RS31400	COG0740	serine-type endopeptidase activity
I6J40_RS31415	COG1309	transcriptional regulator
I6J40_RS31420	COG0831	urea catabolic process
I6J40_RS31425	COG0832	Belongs to the urease beta subunit family
I6J40_RS31430	COG0804	urea catabolic process
I6J40_RS31440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J40_RS31445	COG0829	nickel cation binding
I6J40_RS31460	COG0204	Acyl-transferase
I6J40_RS31475	COG0205	6-phosphofructokinase activity
I6J40_RS31480	COG3442	glutamine amidotransferase
I6J40_RS31490	COG0242	peptide deformylase activity
I6J40_RS31500	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS31505	COG0386	Belongs to the glutathione peroxidase family
I6J40_RS31520	COG1946	Acyl-CoA thioesterase
I6J40_RS31535	COG1793	dna ligase
I6J40_RS31555	COG1132	(ABC) transporter
I6J40_RS31565	COG0673	inositol 2-dehydrogenase activity
I6J40_RS31570	COG0277	FAD linked oxidase domain protein
I6J40_RS31575	COG1846	Transcriptional regulator
I6J40_RS31580	COG1132	(ABC) transporter
I6J40_RS31590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J40_RS31595	COG2072	flavoprotein involved in K transport
I6J40_RS31610	COG1116	anion transmembrane transporter activity
I6J40_RS31615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J40_RS31640	COG2814	Major facilitator Superfamily
I6J40_RS31645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS31655	COG0154	amidase activity
I6J40_RS31660	COG1309	transcriptional regulator
I6J40_RS31670	COG1309	transcriptional regulator
I6J40_RS31695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J40_RS31750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J40_RS31765	COG1891	lyase activity
I6J40_RS31815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS31820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS31830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J40_RS31860	COG2080	2 iron, 2 sulfur cluster binding
I6J40_RS31865	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J40_RS31870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J40_RS31890	COG4912	Dna alkylation repair
I6J40_RS31900	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J40_RS31965	COG0542	response to heat
I6J40_RS31985	COG0402	S-adenosylhomocysteine deaminase activity
I6J40_RS31990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J40_RS31995	COG1802	Transcriptional regulator
I6J40_RS32005	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J40_RS32025	COG4981	capsule polysaccharide biosynthetic process
I6J40_RS32060	COG1012	belongs to the aldehyde dehydrogenase family
I6J40_RS32065	COG0174	glutamine synthetase
I6J40_RS32075	COG0531	amino acid
I6J40_RS32080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J40_RS32115	COG1253	flavin adenine dinucleotide binding
I6J40_RS32145	COG2815	serine threonine protein kinase
I6J40_RS32145	COG0515	serine threonine protein kinase
I6J40_RS32195	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J40_RS32200	COG0107	imidazoleglycerol-phosphate synthase activity
I6J40_RS32220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J40_RS32225	COG3483	tryptophan 2,3-dioxygenase activity
I6J40_RS32230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J40_RS32245	COG2197	response regulator
I6J40_RS32250	COG3961	Belongs to the TPP enzyme family
I6J40_RS32295	COG2706	6-phosphogluconolactonase activity
I6J40_RS32310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J40_RS32355	COG0671	phosphoesterase, PA-phosphatase related
I6J40_RS32375	COG0584	glycerophosphoryl diester phosphodiesterase
I6J40_RS32425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J40_RS32455	COG0494	nUDIX hydrolase
I6J40_RS32465	COG0445	tRNA wobble uridine modification
I6J40_RS32485	COG2223	nitrite transmembrane transporter activity
I6J40_RS32490	COG1940	carbohydrate kinase activity
I6J40_RS32525	COG0702	epimerase
I6J40_RS32540	COG1349	DNA-binding transcription factor activity
I6J40_RS32550	COG0464	growth
I6J40_RS32585	COG5002	protein histidine kinase activity
I6J40_RS32720	COG1132	(ABC) transporter
I6J40_RS32725	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS32730	COG0328	RNA-DNA hybrid ribonuclease activity
I6J40_RS32780	COG1879	ABC-type sugar transport system periplasmic component
I6J40_RS32785	COG1129	ABC transporter
I6J40_RS32795	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J40_RS32800	COG1609	Transcriptional regulator
I6J40_RS32805	COG1874	Beta-galactosidase
I6J40_RS32805	COG0366	Alpha amylase catalytic
I6J40_RS32830	COG0789	Transcriptional regulator
I6J40_RS32840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS32845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS32850	COG1120	ATPase activity
I6J40_RS32935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J40_RS32960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS32965	COG1120	ATPase activity
I6J40_RS32980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J40_RS32985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J40_RS33000	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J40_RS33005	COG3246	L-lysine catabolic process to acetate
I6J40_RS33010	COG1309	transcriptional regulator
I6J40_RS33015	COG1191	sigma factor activity
I6J40_RS33045	COG0488	(ABC) transporter
I6J40_RS33060	COG1461	Dihydroxyacetone kinase
I6J40_RS33065	COG2376	Dihydroxyacetone kinase
I6J40_RS33105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J40_RS33110	COG4221	oxidoreductase activity
I6J40_RS33135	COG1295	ribonuclease BN
I6J40_RS33210	COG0587	DNA-directed DNA polymerase activity
I6J40_RS33220	COG1131	(ABC) transporter
I6J40_RS33225	COG3559	Exporter of polyketide antibiotics
I6J40_RS33255	COG0745	RESPONSE REGULATOR receiver
I6J40_RS33260	COG5002	protein histidine kinase activity
I6J40_RS33275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J40_RS33280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS33285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS33290	COG1120	ATPase activity
I6J40_RS33295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J40_RS33310	COG1132	(ABC) transporter
I6J40_RS33315	COG2382	esterase
I6J40_RS33335	COG0148	phosphopyruvate hydratase activity
I6J40_RS33355	COG3845	ABC transporter
I6J40_RS33390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J40_RS33410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J40_RS33415	COG1535	isochorismatase
I6J40_RS33415	COG3433	isochorismatase activity
I6J40_RS33420	COG1535	isochorismatase
I6J40_RS33420	COG3433	isochorismatase activity
I6J40_RS33425	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J40_RS33430	COG1169	isochorismate synthase
I6J40_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
I6J40_RS33440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J40_RS33450	COG0477	Major facilitator Superfamily
I6J40_RS33460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS33470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J40_RS33475	COG1120	ATPase activity
I6J40_RS33510	COG2365	Tyrosine phosphatase family
I6J40_RS33555	COG2080	2 iron, 2 sulfur cluster binding
I6J40_RS33560	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J40_RS33565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J40_RS33580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J40_RS33585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J40_RS33595	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6J40_RS33595	COG2066	Belongs to the glutaminase family
I6J40_RS33600	COG2356	endonuclease I
I6J40_RS33615	COG2813	Specifically methylates the guanine in position
I6J40_RS33620	COG1960	acyl-CoA dehydrogenase activity
I6J40_RS33635	COG0789	Transcriptional regulator
I6J40_RS33640	COG0659	secondary active sulfate transmembrane transporter activity
I6J40_RS33645	COG0515	serine threonine protein kinase
I6J40_RS33655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J40_RS33660	COG2070	2-Nitropropane dioxygenase
I6J40_RS33690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J40_RS33705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J40_RS33710	COG1132	(ABC) transporter
I6J40_RS33730	COG1024	Enoyl-CoA hydratase
I6J40_RS33780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J40_RS33785	COG0254	rRNA binding
I6J40_RS33810	COG2318	DinB family
I6J40_RS33840	COG0596	Alpha beta hydrolase
I6J40_RS33875	COG1349	DNA-binding transcription factor activity
I6J40_RS33930	COG2318	DinB family
I6J40_RS33945	COG0642	Histidine kinase
I6J40_RS33960	COG0702	epimerase
I6J40_RS33975	COG1064	alcohol dehydrogenase
I6J40_RS33980	COG0640	Transcriptional regulator
I6J40_RS33985	COG1902	pentaerythritol trinitrate reductase activity
I6J40_RS34010	COG0789	Transcriptional regulator
I6J40_RS34020	COG1764	response to oxidative stress
I6J40_RS34025	COG1846	Transcriptional regulator
I6J40_RS34035	COG0477	Major facilitator Superfamily
I6J40_RS34045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J40_RS34080	COG5297	Belongs to the glycosyl hydrolase family 6
I6J40_RS34090	COG4941	Belongs to the sigma-70 factor family
I6J40_RS34110	COG4977	sequence-specific DNA binding
I6J40_RS34135	COG0574	Belongs to the PEP-utilizing enzyme family
I6J40_RS34135	COG3848	Pyruvate phosphate dikinase
I6J40_RS34150	COG0590	tRNA wobble adenosine to inosine editing
I6J40_RS34165	COG0583	DNA-binding transcription factor activity
I6J40_RS34185	COG1132	(ABC) transporter
I6J40_RS34290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J40_RS34335	COG0305	Participates in initiation and elongation during chromosome replication
I6J40_RS34700	COG1475	DNA binding
I6J40_RS34780	COG0629	single-stranded DNA binding
I6J40_RS34855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J40_RS34940	COG1131	(ABC) transporter
I6J40_RS34975	COG0484	heat shock protein binding
I6J40_RS34990	COG0006	proline dipeptidase activity
I6J40_RS34995	COG4934	collagen metabolic process
I6J40_RS35035	COG1191	sigma factor activity
I6J40_RS35095	COG0484	heat shock protein binding
I6J40_RS35170	COG1404	Belongs to the peptidase S8 family
I6J40_RS35180	COG1672	PFAM Archaeal ATPase
I6J40_RS35180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J40_RS35190	COG4264	IucA IucC family
I6J40_RS35200	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J40_RS35225	COG0720	synthase
I6J40_RS35240	COG0302	gtp cyclohydrolase
I6J40_RS35255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J40_RS35295	COG1051	belongs to the nudix hydrolase family
I6J40_RS35305	COG3415	Transposase
I6J40_RS35305	COG2801	Transposase and inactivated derivatives
I6J40_RS35310	COG3293	Transposase
I6J40_RS35340	COG2188	Transcriptional regulator
I6J40_RS35405	COG1674	ftsk spoiiie
I6J40_RS35415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J40_RS35465	COG1192	Involved in chromosome partitioning
I6J40_RS35510	COG0587	DNA-directed DNA polymerase activity
I6J40_RS35515	COG0596	Alpha beta hydrolase
I6J40_RS35555	COG1131	(ABC) transporter
I6J40_RS35585	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J40_RS35600	COG1024	Enoyl-CoA hydratase
I6J40_RS35605	COG0456	acetyltransferase
I6J40_RS35610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS35620	COG0318	PFAM AMP-dependent synthetase and ligase
I6J40_RS35625	COG0019	diaminopimelate decarboxylase activity
I6J40_RS35630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J40_RS35650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J40_RS35660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J40_RS35665	COG1280	lysine exporter protein (LysE YggA)
I6J40_RS35750	COG0039	L-malate dehydrogenase activity
I6J40_RS35830	COG0456	acetyltransferase