locus-tag	class	description
I6J41_RS00090	COG1132	(ABC) transporter
I6J41_RS00130	COG2197	response regulator
I6J41_RS00150	COG0583	DNA-binding transcription factor activity
I6J41_RS00165	COG0590	tRNA wobble adenosine to inosine editing
I6J41_RS00180	COG3848	Pyruvate phosphate dikinase
I6J41_RS00180	COG0574	Belongs to the PEP-utilizing enzyme family
I6J41_RS00225	COG4941	Belongs to the sigma-70 factor family
I6J41_RS00235	COG5297	Belongs to the glycosyl hydrolase family 6
I6J41_RS00270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J41_RS00280	COG0477	Major facilitator Superfamily
I6J41_RS00290	COG1846	Transcriptional regulator
I6J41_RS00295	COG1764	response to oxidative stress
I6J41_RS00305	COG0789	Transcriptional regulator
I6J41_RS00330	COG1902	pentaerythritol trinitrate reductase activity
I6J41_RS00335	COG0640	Transcriptional regulator
I6J41_RS00340	COG1064	alcohol dehydrogenase
I6J41_RS00355	COG0702	epimerase
I6J41_RS00370	COG0642	Histidine kinase
I6J41_RS00385	COG2318	DinB family
I6J41_RS00440	COG1349	DNA-binding transcription factor activity
I6J41_RS00475	COG0596	Alpha beta hydrolase
I6J41_RS00505	COG2318	DinB family
I6J41_RS00530	COG0254	rRNA binding
I6J41_RS00535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J41_RS00585	COG1024	Enoyl-CoA hydratase
I6J41_RS00605	COG1132	(ABC) transporter
I6J41_RS00610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J41_RS00625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J41_RS00655	COG2070	2-Nitropropane dioxygenase
I6J41_RS00660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J41_RS00670	COG0515	serine threonine protein kinase
I6J41_RS00675	COG0659	secondary active sulfate transmembrane transporter activity
I6J41_RS00680	COG0789	Transcriptional regulator
I6J41_RS00695	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS00700	COG2813	Specifically methylates the guanine in position
I6J41_RS00715	COG2356	endonuclease I
I6J41_RS00720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6J41_RS00720	COG2066	Belongs to the glutaminase family
I6J41_RS00730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J41_RS00735	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J41_RS00750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J41_RS00755	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J41_RS00760	COG2080	2 iron, 2 sulfur cluster binding
I6J41_RS00805	COG2365	Tyrosine phosphatase family
I6J41_RS00840	COG1120	ATPase activity
I6J41_RS00845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J41_RS00855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS00865	COG0477	Major facilitator Superfamily
I6J41_RS00875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS00885	COG1169	isochorismate synthase
I6J41_RS00890	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J41_RS00895	COG3433	isochorismatase activity
I6J41_RS00895	COG1535	isochorismatase
I6J41_RS00900	COG3433	isochorismatase activity
I6J41_RS00900	COG1535	isochorismatase
I6J41_RS00905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J41_RS00925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J41_RS00960	COG3845	ABC transporter
I6J41_RS00980	COG0148	phosphopyruvate hydratase activity
I6J41_RS01000	COG2382	esterase
I6J41_RS01005	COG1132	(ABC) transporter
I6J41_RS01020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J41_RS01025	COG1120	ATPase activity
I6J41_RS01030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS01040	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J41_RS01055	COG5002	protein histidine kinase activity
I6J41_RS01060	COG0745	RESPONSE REGULATOR receiver
I6J41_RS01090	COG3559	Exporter of polyketide antibiotics
I6J41_RS01095	COG1131	(ABC) transporter
I6J41_RS01105	COG0587	DNA-directed DNA polymerase activity
I6J41_RS01180	COG1295	ribonuclease BN
I6J41_RS01255	COG4221	oxidoreductase activity
I6J41_RS01270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS01290	COG2376	Dihydroxyacetone kinase
I6J41_RS01295	COG1461	Dihydroxyacetone kinase
I6J41_RS01310	COG0488	(ABC) transporter
I6J41_RS01340	COG1191	sigma factor activity
I6J41_RS01345	COG1309	transcriptional regulator
I6J41_RS01350	COG3246	L-lysine catabolic process to acetate
I6J41_RS01355	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS01370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J41_RS01390	COG1120	ATPase activity
I6J41_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS01420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS01475	COG1959	2 iron, 2 sulfur cluster binding
I6J41_RS01475	COG1295	ribonuclease BN
I6J41_RS01505	COG1120	ATPase activity
I6J41_RS01510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS01515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS01550	COG0366	Alpha amylase catalytic
I6J41_RS01550	COG1874	Beta-galactosidase
I6J41_RS01555	COG1609	Transcriptional regulator
I6J41_RS01560	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J41_RS01570	COG1129	ABC transporter
I6J41_RS01575	COG1879	ABC-type sugar transport system periplasmic component
I6J41_RS01630	COG0328	RNA-DNA hybrid ribonuclease activity
I6J41_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS01640	COG1132	(ABC) transporter
I6J41_RS01780	COG5002	protein histidine kinase activity
I6J41_RS01815	COG0464	growth
I6J41_RS01825	COG1349	DNA-binding transcription factor activity
I6J41_RS01840	COG0702	epimerase
I6J41_RS01875	COG1940	carbohydrate kinase activity
I6J41_RS01880	COG2223	nitrite transmembrane transporter activity
I6J41_RS01900	COG0445	tRNA wobble uridine modification
I6J41_RS01910	COG0494	nUDIX hydrolase
I6J41_RS01940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J41_RS01990	COG0584	glycerophosphoryl diester phosphodiesterase
I6J41_RS02010	COG0671	phosphoesterase, PA-phosphatase related
I6J41_RS02055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J41_RS02070	COG2706	6-phosphogluconolactonase activity
I6J41_RS02115	COG3961	Belongs to the TPP enzyme family
I6J41_RS02120	COG2197	response regulator
I6J41_RS02135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J41_RS02140	COG3483	tryptophan 2,3-dioxygenase activity
I6J41_RS02145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J41_RS02165	COG0107	imidazoleglycerol-phosphate synthase activity
I6J41_RS02220	COG0515	serine threonine protein kinase
I6J41_RS02220	COG2815	serine threonine protein kinase
I6J41_RS02225	COG0667	Aldo Keto reductase
I6J41_RS02250	COG1253	flavin adenine dinucleotide binding
I6J41_RS02285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J41_RS02290	COG0531	amino acid
I6J41_RS02300	COG0174	glutamine synthetase
I6J41_RS02305	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS02340	COG4981	capsule polysaccharide biosynthetic process
I6J41_RS02360	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J41_RS02370	COG1802	Transcriptional regulator
I6J41_RS02375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J41_RS02380	COG0402	S-adenosylhomocysteine deaminase activity
I6J41_RS02400	COG0542	response to heat
I6J41_RS02455	COG1335	isochorismatase
I6J41_RS02470	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J41_RS02500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J41_RS02505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J41_RS02510	COG2080	2 iron, 2 sulfur cluster binding
I6J41_RS02540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J41_RS02550	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS02605	COG1891	lyase activity
I6J41_RS02620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J41_RS02675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J41_RS02700	COG1309	transcriptional regulator
I6J41_RS02705	COG1982	Orn Lys Arg decarboxylase major
I6J41_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS02725	COG1309	transcriptional regulator
I6J41_RS02780	COG2814	Major facilitator Superfamily
I6J41_RS02800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J41_RS02845	COG1959	2 iron, 2 sulfur cluster binding
I6J41_RS02870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J41_RS02880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J41_RS02885	COG1116	anion transmembrane transporter activity
I6J41_RS02900	COG2072	flavoprotein involved in K transport
I6J41_RS02905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J41_RS02915	COG1132	(ABC) transporter
I6J41_RS02920	COG1846	Transcriptional regulator
I6J41_RS02925	COG0277	FAD linked oxidase domain protein
I6J41_RS02930	COG0673	inositol 2-dehydrogenase activity
I6J41_RS02935	COG1132	(ABC) transporter
I6J41_RS02940	COG1132	(ABC) transporter
I6J41_RS02960	COG1793	dna ligase
I6J41_RS02975	COG1946	Acyl-CoA thioesterase
I6J41_RS02990	COG0386	Belongs to the glutathione peroxidase family
I6J41_RS02995	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS03005	COG0242	peptide deformylase activity
I6J41_RS03015	COG3442	glutamine amidotransferase
I6J41_RS03020	COG0205	6-phosphofructokinase activity
I6J41_RS03035	COG0204	Acyl-transferase
I6J41_RS03050	COG0829	nickel cation binding
I6J41_RS03055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J41_RS03065	COG0804	urea catabolic process
I6J41_RS03070	COG0832	Belongs to the urease beta subunit family
I6J41_RS03075	COG0831	urea catabolic process
I6J41_RS03080	COG1309	transcriptional regulator
I6J41_RS03095	COG0740	serine-type endopeptidase activity
I6J41_RS03110	COG1280	lysine exporter protein (LysE YggA)
I6J41_RS03115	COG0583	DNA-binding transcription factor activity
I6J41_RS03135	COG0156	8-amino-7-oxononanoate synthase activity
I6J41_RS03140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J41_RS03145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J41_RS03150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J41_RS03195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J41_RS03205	COG1940	carbohydrate kinase activity
I6J41_RS03210	COG2188	Transcriptional regulator
I6J41_RS03215	COG1595	DNA-templated transcription, initiation
I6J41_RS03230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J41_RS03255	COG0626	cystathionine gamma-synthase activity
I6J41_RS03275	COG0419	ATPase involved in DNA repair
I6J41_RS03280	COG0420	3'-5' exonuclease activity
I6J41_RS03285	COG1739	Uncharacterized protein family UPF0029
I6J41_RS03290	COG1832	CoA-binding protein
I6J41_RS03330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J41_RS03350	COG1968	undecaprenyl-diphosphatase activity
I6J41_RS03380	COG2226	methyltransferase
I6J41_RS03445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J41_RS03505	COG0069	glutamate synthase activity
I6J41_RS03560	COG0477	Major facilitator Superfamily
I6J41_RS03575	COG0784	Response regulator, receiver
I6J41_RS03580	COG4251	negative regulation of phosphorylation
I6J41_RS03585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J41_RS03595	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J41_RS03605	COG1215	transferase activity, transferring glycosyl groups
I6J41_RS03625	COG3800	Transcriptional regulator
I6J41_RS03625	COG1396	sequence-specific DNA binding
I6J41_RS03725	COG1695	Transcriptional regulator
I6J41_RS03750	COG1595	DNA-templated transcription, initiation
I6J41_RS03805	COG0384	phenazine biosynthesis protein PhzF
I6J41_RS03835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J41_RS03835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J41_RS03845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J41_RS03865	COG1716	ATPase activity
I6J41_RS03885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J41_RS03915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J41_RS03925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J41_RS03940	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J41_RS03970	COG2018	Roadblock/LC7 domain
I6J41_RS04035	COG2364	Membrane
I6J41_RS04045	COG2270	Major facilitator Superfamily
I6J41_RS04060	COG1216	Glycosyl transferase, family 2
I6J41_RS04080	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS04085	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS04095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J41_RS04140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J41_RS04145	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J41_RS04150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J41_RS04155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J41_RS04155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J41_RS04160	COG3201	nicotinamide mononucleotide transporter
I6J41_RS04185	COG0738	Major facilitator superfamily
I6J41_RS04190	COG2233	PERMEase
I6J41_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS04215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J41_RS04235	COG0142	geranyltranstransferase activity
I6J41_RS04250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J41_RS04260	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS04275	COG2390	Transcriptional regulator
I6J41_RS04280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J41_RS04290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J41_RS04305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J41_RS04315	COG1758	RNA polymerase activity
I6J41_RS04330	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J41_RS04335	COG0167	dihydroorotate dehydrogenase activity
I6J41_RS04340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J41_RS04345	COG0505	Belongs to the CarA family
I6J41_RS04355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J41_RS04360	COG0540	Belongs to the ATCase OTCase family
I6J41_RS04365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J41_RS04375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J41_RS04380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J41_RS04385	COG0006	proline dipeptidase activity
I6J41_RS04395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J41_RS04400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J41_RS04405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J41_RS04410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J41_RS04420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J41_RS04425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J41_RS04445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J41_RS04465	COG0124	histidyl-tRNA synthetase
I6J41_RS04480	COG1196	nuclear chromosome segregation
I6J41_RS04500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J41_RS04505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J41_RS04510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J41_RS04515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J41_RS04525	COG2255	four-way junction helicase activity
I6J41_RS04530	COG0632	four-way junction helicase activity
I6J41_RS04535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J41_RS04540	COG0217	transcriptional regulatory protein
I6J41_RS04545	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J41_RS04550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J41_RS04560	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS04565	COG1560	Kdo2-lipid A biosynthetic process
I6J41_RS04570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J41_RS04590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J41_RS04605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J41_RS04665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J41_RS04720	COG1648	precorrin-2 dehydrogenase activity
I6J41_RS04720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J41_RS04725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J41_RS04740	COG1464	Belongs to the NlpA lipoprotein family
I6J41_RS04745	COG2011	ABC-type metal ion transport system permease component
I6J41_RS04785	COG0477	Major facilitator Superfamily
I6J41_RS04795	COG3973	AAA domain
I6J41_RS04805	COG0165	Argininosuccinate lyase
I6J41_RS04810	COG0137	argininosuccinate synthase activity
I6J41_RS04825	COG1438	arginine binding
I6J41_RS04830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J41_RS04835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J41_RS04840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J41_RS04845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J41_RS04905	COG0697	spore germination
I6J41_RS04915	COG1649	PFAM Uncharacterised BCR, COG1649
I6J41_RS04940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J41_RS04940	COG0072	phenylalanine-tRNA ligase activity
I6J41_RS04945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J41_RS04950	COG5002	protein histidine kinase activity
I6J41_RS04955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J41_RS04960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J41_RS04965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J41_RS04970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J41_RS04980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J41_RS05035	COG0517	IMP dehydrogenase activity
I6J41_RS05035	COG4175	Glycine betaine
I6J41_RS05040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J41_RS05070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J41_RS05075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J41_RS05115	COG0805	protein transport
I6J41_RS05120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J41_RS05140	COG2378	regulation of single-species biofilm formation
I6J41_RS05150	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J41_RS05155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J41_RS05165	COG1609	Transcriptional regulator
I6J41_RS05170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J41_RS05175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J41_RS05185	COG4122	O-methyltransferase activity
I6J41_RS05190	COG1222	aaa ATPase
I6J41_RS05210	COG0517	IMP dehydrogenase activity
I6J41_RS05210	COG1994	Peptidase M50
I6J41_RS05220	COG2197	response regulator
I6J41_RS05225	COG4166	transmembrane transport
I6J41_RS05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS05235	COG1410	methionine synthase
I6J41_RS05235	COG0646	methionine synthase
I6J41_RS05240	COG1414	Transcriptional regulator
I6J41_RS05245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J41_RS05250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J41_RS05255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J41_RS05260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS05270	COG0215	cysteine-tRNA ligase activity
I6J41_RS05290	COG0598	Magnesium transport protein CorA
I6J41_RS05300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS05305	COG0667	Aldo Keto reductase
I6J41_RS05335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J41_RS05345	COG0564	pseudouridine synthase activity
I6J41_RS05360	COG2186	Transcriptional regulator
I6J41_RS05365	COG3265	gluconokinase activity
I6J41_RS05395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J41_RS05400	COG2149	membrane
I6J41_RS05420	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS05425	COG4935	Belongs to the peptidase S8 family
I6J41_RS05425	COG2234	aminopeptidase activity
I6J41_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS05445	COG3876	Protein conserved in bacteria
I6J41_RS05480	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS05495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J41_RS05505	COG2318	DinB family
I6J41_RS05515	COG2851	Citrate transporter
I6J41_RS05520	COG1309	transcriptional regulator
I6J41_RS05540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6J41_RS05545	COG2188	Transcriptional regulator
I6J41_RS05555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J41_RS05565	COG2755	lipolytic protein G-D-S-L family
I6J41_RS05575	COG1725	Transcriptional regulator
I6J41_RS05590	COG0346	lactoylglutathione lyase activity
I6J41_RS05610	COG4565	transcriptional regulatory protein
I6J41_RS05645	COG4585	Histidine kinase
I6J41_RS05650	COG2197	response regulator
I6J41_RS05670	COG0641	radical SAM
I6J41_RS05705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS05710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS05715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS05720	COG1126	abc transporter atp-binding protein
I6J41_RS05735	COG0765	amino acid transport
I6J41_RS05740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS05750	COG1799	cell septum assembly
I6J41_RS05755	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS05760	COG0477	Major facilitator Superfamily
I6J41_RS05765	COG0671	phosphoesterase, PA-phosphatase related
I6J41_RS05780	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS05795	COG1160	GTP binding
I6J41_RS05805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J41_RS05830	COG0494	nUDIX hydrolase
I6J41_RS05845	COG1187	pseudouridine synthase activity
I6J41_RS05850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J41_RS05855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J41_RS05870	COG0686	Belongs to the AlaDH PNT family
I6J41_RS05880	COG0494	nUDIX hydrolase
I6J41_RS05885	COG0504	CTP synthase activity
I6J41_RS05890	COG3387	PFAM Glycoside hydrolase 15-related
I6J41_RS05915	COG0497	DNA recombination
I6J41_RS05920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J41_RS05940	COG1120	ATPase activity
I6J41_RS05945	COG0647	UMP catabolic process
I6J41_RS05980	COG2094	Belongs to the DNA glycosylase MPG family
I6J41_RS05990	COG1881	PFAM PEBP family protein
I6J41_RS06015	COG1119	ATPase activity
I6J41_RS06025	COG2197	response regulator
I6J41_RS06030	COG4585	Histidine kinase
I6J41_RS06040	COG0842	Transport permease protein
I6J41_RS06040	COG1131	(ABC) transporter
I6J41_RS06040	COG1716	ATPase activity
I6J41_RS06045	COG3830	Belongs to the UPF0237 family
I6J41_RS06045	COG0560	Phosphoserine phosphatase
I6J41_RS06075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J41_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS06105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J41_RS06110	COG2261	transglycosylase associated protein
I6J41_RS06125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J41_RS06130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J41_RS06170	COG3387	PFAM Glycoside hydrolase 15-related
I6J41_RS06210	COG1024	Enoyl-CoA hydratase
I6J41_RS06220	COG0488	(ABC) transporter
I6J41_RS06245	COG0235	Class ii aldolase
I6J41_RS06260	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J41_RS06265	COG1492	cobalamin metabolic process
I6J41_RS06280	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J41_RS06305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J41_RS06335	COG1902	pentaerythritol trinitrate reductase activity
I6J41_RS06385	COG4585	Histidine kinase
I6J41_RS06390	COG2197	response regulator
I6J41_RS06395	COG0768	penicillin binding
I6J41_RS06435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J41_RS06440	COG2171	N-acyltransferase activity
I6J41_RS06445	COG3226	Transcriptional regulator
I6J41_RS06460	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J41_RS06465	COG0822	iron-sulfur transferase activity
I6J41_RS06470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J41_RS06475	COG0396	ATPase activity
I6J41_RS06485	COG0719	Fe-S assembly protein
I6J41_RS06520	COG0109	protoheme IX farnesyltransferase activity
I6J41_RS06530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J41_RS06545	COG0363	glucosamine-6-phosphate deaminase activity
I6J41_RS06555	COG4195	phage-related replication protein
I6J41_RS06570	COG0166	Belongs to the GPI family
I6J41_RS06580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J41_RS06585	COG0149	triose-phosphate isomerase activity
I6J41_RS06590	COG0126	phosphoglycerate kinase activity
I6J41_RS06595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J41_RS06600	COG1481	regulation of sporulation
I6J41_RS06605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J41_RS06610	COG1660	Displays ATPase and GTPase activities
I6J41_RS06615	COG0322	excinuclease ABC activity
I6J41_RS06640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J41_RS06670	COG0556	nucleotide-excision repair
I6J41_RS06680	COG0584	glycerophosphoryl diester phosphodiesterase
I6J41_RS06690	COG2814	Major facilitator Superfamily
I6J41_RS06700	COG2313	pseudouridylate synthase activity
I6J41_RS06720	COG0436	Aminotransferase
I6J41_RS06740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J41_RS06750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J41_RS06770	COG0237	dephospho-CoA kinase activity
I6J41_RS06795	COG1643	Atp-dependent helicase
I6J41_RS06830	COG2050	protein possibly involved in aromatic compounds catabolism
I6J41_RS06840	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J41_RS06885	COG0737	Belongs to the 5'-nucleotidase family
I6J41_RS06920	COG1605	Chorismate mutase
I6J41_RS06920	COG0287	Prephenate dehydrogenase
I6J41_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS06960	COG1024	Enoyl-CoA hydratase
I6J41_RS06985	COG1278	Cold shock
I6J41_RS06990	COG0183	Belongs to the thiolase family
I6J41_RS06995	COG1309	transcriptional regulator
I6J41_RS07005	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS07035	COG0705	Rhomboid family
I6J41_RS07045	COG0070	glutamate synthase
I6J41_RS07045	COG0069	glutamate synthase activity
I6J41_RS07045	COG0067	glutamate synthase
I6J41_RS07075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J41_RS07080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J41_RS07090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J41_RS07100	COG0159	tryptophan synthase activity
I6J41_RS07105	COG0133	tryptophan synthase activity
I6J41_RS07115	COG0134	indole-3-glycerol-phosphate synthase activity
I6J41_RS07135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J41_RS07140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J41_RS07160	COG0107	imidazoleglycerol-phosphate synthase activity
I6J41_RS07165	COG0251	oxidation-reduction process
I6J41_RS07170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J41_RS07175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J41_RS07185	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J41_RS07190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J41_RS07195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J41_RS07215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J41_RS07240	COG1432	Conserved Protein
I6J41_RS07250	COG0587	DNA-directed DNA polymerase activity
I6J41_RS07295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J41_RS07305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J41_RS07310	COG3599	regulation of cell shape
I6J41_RS07320	COG1799	cell septum assembly
I6J41_RS07325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J41_RS07345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J41_RS07355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J41_RS07360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J41_RS07370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J41_RS07375	COG0768	penicillin binding
I6J41_RS07385	COG0275	rRNA processing
I6J41_RS07395	COG0714	Associated with various cellular activities
I6J41_RS07415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J41_RS07425	COG1136	(ABC) transporter
I6J41_RS07425	COG0577	efflux transmembrane transporter activity
I6J41_RS07445	COG1233	COG1233 Phytoene dehydrogenase and related
I6J41_RS07460	COG0352	thiamine-phosphate diphosphorylase activity
I6J41_RS07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J41_RS07480	COG2022	thiamine diphosphate biosynthetic process
I6J41_RS07490	COG2022	thiamine diphosphate biosynthetic process
I6J41_RS07495	COG0515	serine threonine protein kinase
I6J41_RS07495	COG2815	serine threonine protein kinase
I6J41_RS07500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J41_RS07505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J41_RS07510	COG2193	ferroxidase activity
I6J41_RS07520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J41_RS07535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J41_RS07540	COG2197	response regulator
I6J41_RS07570	COG1940	carbohydrate kinase activity
I6J41_RS07580	COG0003	Pfam Anion-transporting ATPase
I6J41_RS07645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J41_RS07650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J41_RS07655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J41_RS07660	COG0723	plastoquinol--plastocyanin reductase activity
I6J41_RS07665	COG2010	Cytochrome c
I6J41_RS07670	COG1845	cytochrome c oxidase, subunit III
I6J41_RS07680	COG1376	ErfK ybiS ycfS ynhG family protein
I6J41_RS07690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J41_RS07695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J41_RS07705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J41_RS07725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J41_RS07735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J41_RS07740	COG2197	response regulator
I6J41_RS07745	COG4585	Histidine kinase
I6J41_RS07770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J41_RS07785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J41_RS07800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J41_RS07805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J41_RS07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J41_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J41_RS07825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J41_RS07845	COG1090	epimerase
I6J41_RS07865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J41_RS07890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J41_RS07895	COG3896	Chloramphenicol phosphotransferase-like protein
I6J41_RS07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J41_RS07930	COG0673	inositol 2-dehydrogenase activity
I6J41_RS07950	COG0745	RESPONSE REGULATOR receiver
I6J41_RS07955	COG2409	Drug exporters of the RND superfamily
I6J41_RS07960	COG4585	Histidine kinase
I6J41_RS07965	COG2197	response regulator
I6J41_RS08025	COG0366	Alpha amylase catalytic
I6J41_RS08030	COG0395	ABC-type sugar transport system, permease component
I6J41_RS08040	COG2182	Extracellular solute-binding protein
I6J41_RS08045	COG1609	Transcriptional regulator
I6J41_RS08055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J41_RS08060	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J41_RS08065	COG0477	Major facilitator Superfamily
I6J41_RS08105	COG0494	nUDIX hydrolase
I6J41_RS08120	COG0174	glutamine synthetase
I6J41_RS08135	COG2132	Multicopper oxidase
I6J41_RS08140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J41_RS08140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J41_RS08145	COG2814	Major facilitator Superfamily
I6J41_RS08160	COG0477	Major facilitator Superfamily
I6J41_RS08165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J41_RS08185	COG1994	Peptidase M50
I6J41_RS08245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS08250	COG1120	ATPase activity
I6J41_RS08270	COG1834	amidinotransferase
I6J41_RS08285	COG2814	Major facilitator Superfamily
I6J41_RS08295	COG3540	Alkaline phosphatase
I6J41_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS08310	COG0384	phenazine biosynthesis protein PhzF
I6J41_RS08350	COG2273	Hydrolase Family 16
I6J41_RS08375	COG3022	response to hydroperoxide
I6J41_RS08380	COG0800	Aldolase
I6J41_RS08395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J41_RS08400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J41_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS08425	COG2030	dehydratase
I6J41_RS08435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J41_RS08440	COG0183	Belongs to the thiolase family
I6J41_RS08445	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS08455	COG3340	Belongs to the peptidase S51 family
I6J41_RS08470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J41_RS08475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J41_RS08495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS08520	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS08525	COG1309	transcriptional regulator
I6J41_RS08580	COG3845	ABC transporter
I6J41_RS08595	COG0183	Belongs to the thiolase family
I6J41_RS08600	COG2124	cytochrome p450
I6J41_RS08645	COG2259	Doxx family
I6J41_RS08720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J41_RS08725	COG2188	Transcriptional regulator
I6J41_RS08780	COG0582	viral genome integration into host DNA
I6J41_RS08815	COG1358	cellular component organization or biogenesis
I6J41_RS08860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J41_RS08870	COG0477	Major facilitator Superfamily
I6J41_RS08875	COG1309	transcriptional regulator
I6J41_RS08890	COG4585	Histidine kinase
I6J41_RS08895	COG2197	response regulator
I6J41_RS08910	COG0667	Aldo Keto reductase
I6J41_RS08915	COG0789	Transcriptional regulator
I6J41_RS08925	COG2205	protein histidine kinase activity
I6J41_RS08930	COG0745	RESPONSE REGULATOR receiver
I6J41_RS08940	COG0667	Aldo Keto reductase
I6J41_RS08950	COG1929	Belongs to the glycerate kinase type-1 family
I6J41_RS09025	COG1674	ftsk spoiiie
I6J41_RS09030	COG1404	Belongs to the peptidase S8 family
I6J41_RS09085	COG2957	Belongs to the agmatine deiminase family
I6J41_RS09090	COG0456	acetyltransferase
I6J41_RS09100	COG1741	Belongs to the pirin family
I6J41_RS09145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J41_RS09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS09155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS09180	COG1764	response to oxidative stress
I6J41_RS09185	COG2130	NADP-dependent
I6J41_RS09215	COG1522	sequence-specific DNA binding
I6J41_RS09225	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS09230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J41_RS09230	COG0825	malonyl-CoA metabolic process
I6J41_RS09235	COG0477	Major facilitator Superfamily
I6J41_RS09260	COG1070	Carbohydrate kinase
I6J41_RS09275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J41_RS09280	COG0358	DNA primase activity
I6J41_RS09290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J41_RS09300	COG2949	membrane
I6J41_RS09345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J41_RS09345	COG2146	nitrite reductase [NAD(P)H] activity
I6J41_RS09370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J41_RS09370	COG0574	Belongs to the PEP-utilizing enzyme family
I6J41_RS09375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS09380	COG3842	ATPase activity
I6J41_RS09400	COG2188	Transcriptional regulator
I6J41_RS09430	COG0477	Major facilitator Superfamily
I6J41_RS09435	COG2066	Belongs to the glutaminase family
I6J41_RS09450	COG1309	transcriptional regulator
I6J41_RS09580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J41_RS09595	COG0277	FAD linked oxidase domain protein
I6J41_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS09605	COG2124	cytochrome p450
I6J41_RS09640	COG0477	Major facilitator Superfamily
I6J41_RS09645	COG2345	Transcriptional regulator
I6J41_RS09670	COG0367	asparagine synthase
I6J41_RS09680	COG0662	Cupin 2, conserved barrel domain protein
I6J41_RS09685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS09690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS09700	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS09715	COG3104	oligopeptide transport
I6J41_RS09725	COG0423	glycine-tRNA ligase activity
I6J41_RS09735	COG1121	(ABC) transporter
I6J41_RS09740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J41_RS09750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J41_RS09755	COG1381	Involved in DNA repair and RecF pathway recombination
I6J41_RS09765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J41_RS09780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J41_RS09795	COG2315	Protein conserved in bacteria
I6J41_RS09805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J41_RS09815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J41_RS09815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J41_RS09825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J41_RS09830	COG1234	tRNA 3'-trailer cleavage
I6J41_RS09835	COG0537	adenosine 5'-monophosphoramidase activity
I6J41_RS09850	COG0484	heat shock protein binding
I6J41_RS09855	COG1420	regulation of RNA biosynthetic process
I6J41_RS09895	COG0481	GTPase activity
I6J41_RS09900	COG0268	Binds directly to 16S ribosomal RNA
I6J41_RS09925	COG1234	tRNA 3'-trailer cleavage
I6J41_RS09930	COG1555	photosystem II stabilization
I6J41_RS09935	COG1307	EDD domain protein, DegV family
I6J41_RS09945	COG0495	leucyl-tRNA aminoacylation
I6J41_RS09965	COG0588	phosphoglycerate mutase activity
I6J41_RS09970	COG0799	negative regulation of ribosome biogenesis
I6J41_RS09980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J41_RS09995	COG0501	Belongs to the peptidase M48B family
I6J41_RS10010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J41_RS10020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J41_RS10045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J41_RS10050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J41_RS10055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J41_RS10060	COG1530	ribonuclease E activity
I6J41_RS10085	COG0772	Belongs to the SEDS family
I6J41_RS10090	COG0768	penicillin binding
I6J41_RS10105	COG1077	Cell shape determining protein MreB Mrl
I6J41_RS10110	COG0105	UTP biosynthetic process
I6J41_RS10120	COG0285	dihydrofolate synthase activity
I6J41_RS10125	COG0525	valine-tRNA ligase activity
I6J41_RS10135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J41_RS10140	COG0740	serine-type endopeptidase activity
I6J41_RS10145	COG0740	serine-type endopeptidase activity
I6J41_RS10150	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J41_RS10170	COG3594	Acyltransferase
I6J41_RS10180	COG0475	glutathione-regulated potassium exporter activity
I6J41_RS10200	COG1113	amino acid transport
I6J41_RS10210	COG1268	BioY protein
I6J41_RS10215	COG1113	amino acid transport
I6J41_RS10225	COG0584	glycerophosphoryl diester phosphodiesterase
I6J41_RS10230	COG0783	Belongs to the Dps family
I6J41_RS10240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J41_RS10245	COG0640	Transcriptional regulator
I6J41_RS10260	COG0110	maltose O-acetyltransferase activity
I6J41_RS10265	COG1404	Belongs to the peptidase S8 family
I6J41_RS10285	COG2252	PERMEase
I6J41_RS10295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J41_RS10320	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J41_RS10345	COG4266	Belongs to the allantoicase family
I6J41_RS10350	COG0583	DNA-binding transcription factor activity
I6J41_RS10370	COG3291	Pkd domain containing protein
I6J41_RS10370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J41_RS10380	COG0668	transmembrane transport
I6J41_RS10400	COG1940	carbohydrate kinase activity
I6J41_RS10410	COG1175	transmembrane transport
I6J41_RS10415	COG0395	ABC-type sugar transport system, permease component
I6J41_RS10420	COG1486	melibiose metabolic process
I6J41_RS10435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS10465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J41_RS10485	COG0577	efflux transmembrane transporter activity
I6J41_RS10485	COG1136	(ABC) transporter
I6J41_RS10510	COG0629	single-stranded DNA binding
I6J41_RS10545	COG1674	ftsk spoiiie
I6J41_RS10645	COG4585	Histidine kinase
I6J41_RS10665	COG3962	Belongs to the TPP enzyme family
I6J41_RS10670	COG3718	enzyme involved in inositol metabolism
I6J41_RS10680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J41_RS10690	COG2318	DinB family
I6J41_RS10730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J41_RS10755	COG0596	Alpha beta hydrolase
I6J41_RS10805	COG0673	inositol 2-dehydrogenase activity
I6J41_RS10810	COG1609	Transcriptional regulator
I6J41_RS10845	COG0515	serine threonine protein kinase
I6J41_RS10880	COG1404	Belongs to the peptidase S8 family
I6J41_RS10905	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J41_RS10920	COG0477	Major facilitator Superfamily
I6J41_RS10950	COG0028	Belongs to the TPP enzyme family
I6J41_RS10985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J41_RS11010	COG1946	Acyl-CoA thioesterase
I6J41_RS11040	COG1309	transcriptional regulator
I6J41_RS11045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J41_RS11060	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS11080	COG0076	glutamate decarboxylase activity
I6J41_RS11085	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J41_RS11110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J41_RS11120	COG4977	sequence-specific DNA binding
I6J41_RS11155	COG0395	ABC-type sugar transport system, permease component
I6J41_RS11170	COG2985	domain, Protein
I6J41_RS11185	COG0745	RESPONSE REGULATOR receiver
I6J41_RS11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS11270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J41_RS11280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS11285	COG0765	amino acid transport
I6J41_RS11290	COG0765	amino acid transport
I6J41_RS11295	COG1126	abc transporter atp-binding protein
I6J41_RS11300	COG1414	Transcriptional regulator
I6J41_RS11310	COG3397	chitin binding
I6J41_RS11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J41_RS11380	COG2188	Transcriptional regulator
I6J41_RS11390	COG1940	carbohydrate kinase activity
I6J41_RS11395	COG0673	inositol 2-dehydrogenase activity
I6J41_RS11400	COG4702	Belongs to the UPF0303 family
I6J41_RS11405	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J41_RS11410	COG0706	membrane insertase activity
I6J41_RS11410	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
I6J41_RS11420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J41_RS11430	COG3764	Sortase (surface protein transpeptidase)
I6J41_RS11470	COG3655	Transcriptional regulator
I6J41_RS11500	COG3135	benzoate transporter
I6J41_RS11505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J41_RS11520	COG2175	clavaminate synthase activity
I6J41_RS11530	COG0596	Alpha beta hydrolase
I6J41_RS11540	COG2733	membrane
I6J41_RS11555	COG4555	ABC transporter
I6J41_RS11570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J41_RS11595	COG0477	Major facilitator Superfamily
I6J41_RS11615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J41_RS11625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J41_RS11630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J41_RS11635	COG1263	PTS System
I6J41_RS11640	COG1263	PTS System
I6J41_RS11650	COG1234	tRNA 3'-trailer cleavage
I6J41_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS11690	COG1113	amino acid transport
I6J41_RS11700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J41_RS11710	COG1335	isochorismatase
I6J41_RS11745	COG0277	FAD linked oxidase domain protein
I6J41_RS11755	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J41_RS11765	COG1174	glycine betaine transport
I6J41_RS11770	COG1125	glycine betaine transport
I6J41_RS11770	COG0517	IMP dehydrogenase activity
I6J41_RS11775	COG1174	glycine betaine transport
I6J41_RS11780	COG1732	Glycine betaine
I6J41_RS11800	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J41_RS11835	COG3654	unkown
I6J41_RS11895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J41_RS11900	COG0395	ABC-type sugar transport system, permease component
I6J41_RS11910	COG2182	Extracellular solute-binding protein
I6J41_RS11920	COG1678	Uncharacterized ACR, COG1678
I6J41_RS11925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J41_RS11930	COG0776	regulation of translation
I6J41_RS11940	COG3973	AAA domain
I6J41_RS11940	COG3973	AAA domain
I6J41_RS11965	COG2223	nitrite transmembrane transporter activity
I6J41_RS11970	COG0583	DNA-binding transcription factor activity
I6J41_RS12015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J41_RS12020	COG0793	Belongs to the peptidase S41A family
I6J41_RS12025	COG2177	Part of the ABC transporter FtsEX involved in
I6J41_RS12030	COG2884	Cell division ATP-binding protein ftsE
I6J41_RS12045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J41_RS12050	COG0515	serine threonine protein kinase
I6J41_RS12055	COG0515	serine threonine protein kinase
I6J41_RS12065	COG1653	transport
I6J41_RS12070	COG1175	transmembrane transport
I6J41_RS12075	COG0395	ABC-type sugar transport system, permease component
I6J41_RS12080	COG1216	Glycosyl transferase, family 2
I6J41_RS12080	COG1442	glycosyl transferase family 8
I6J41_RS12085	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS12090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J41_RS12095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J41_RS12100	COG4122	O-methyltransferase activity
I6J41_RS12105	COG1073	alpha beta
I6J41_RS12105	COG2226	methyltransferase
I6J41_RS12110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J41_RS12115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J41_RS12125	COG1309	transcriptional regulator
I6J41_RS12135	COG1134	teichoic acid transport
I6J41_RS12140	COG2902	Dehydrogenase
I6J41_RS12160	COG0653	protein targeting
I6J41_RS12175	COG2197	response regulator
I6J41_RS12180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J41_RS12190	COG0823	Involved in the tonB-independent uptake of proteins
I6J41_RS12195	COG5002	protein histidine kinase activity
I6J41_RS12195	COG5000	phosphorelay sensor kinase activity
I6J41_RS12200	COG0745	RESPONSE REGULATOR receiver
I6J41_RS12280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J41_RS12300	COG0714	Associated with various cellular activities
I6J41_RS12340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J41_RS12360	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J41_RS12365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J41_RS12400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J41_RS12405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J41_RS12405	COG0778	Nitroreductase
I6J41_RS12410	COG0531	amino acid
I6J41_RS12435	COG1316	TRANSCRIPTIONal
I6J41_RS12440	COG1316	TRANSCRIPTIONal
I6J41_RS12445	COG1316	TRANSCRIPTIONal
I6J41_RS12450	COG1316	TRANSCRIPTIONal
I6J41_RS12460	COG1316	TRANSCRIPTIONal
I6J41_RS12530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J41_RS12560	COG2205	protein histidine kinase activity
I6J41_RS12565	COG0745	RESPONSE REGULATOR receiver
I6J41_RS12570	COG3104	oligopeptide transport
I6J41_RS12600	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS12605	COG1191	sigma factor activity
I6J41_RS12610	COG1228	amidohydrolase
I6J41_RS12620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J41_RS12625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J41_RS12630	COG0531	amino acid
I6J41_RS12670	COG2755	lipolytic protein G-D-S-L family
I6J41_RS12675	COG0183	Belongs to the thiolase family
I6J41_RS12700	COG1136	(ABC) transporter
I6J41_RS12705	COG1136	(ABC) transporter
I6J41_RS12705	COG0577	efflux transmembrane transporter activity
I6J41_RS12710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J41_RS12715	COG1252	NADH dehydrogenase
I6J41_RS12735	COG0148	phosphopyruvate hydratase activity
I6J41_RS12745	COG1652	LysM domain
I6J41_RS12770	COG0515	serine threonine protein kinase
I6J41_RS12770	COG2815	serine threonine protein kinase
I6J41_RS12790	COG1335	isochorismatase
I6J41_RS12835	COG1473	amidohydrolase
I6J41_RS12890	COG3629	intracellular signal transduction
I6J41_RS12890	COG3903	Transcriptional regulator
I6J41_RS12900	COG0577	efflux transmembrane transporter activity
I6J41_RS12905	COG1136	(ABC) transporter
I6J41_RS12910	COG0477	Major facilitator Superfamily
I6J41_RS12915	COG0346	lactoylglutathione lyase activity
I6J41_RS12960	COG2124	cytochrome p450
I6J41_RS12990	COG2226	methyltransferase
I6J41_RS13005	COG4585	Histidine kinase
I6J41_RS13015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J41_RS13020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J41_RS13025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J41_RS13030	COG0193	aminoacyl-tRNA hydrolase activity
I6J41_RS13035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J41_RS13060	COG4106	trans-aconitate 2-methyltransferase activity
I6J41_RS13065	COG1846	Transcriptional regulator
I6J41_RS13070	COG2197	response regulator
I6J41_RS13080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J41_RS13095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J41_RS13120	COG0488	(ABC) transporter
I6J41_RS13140	COG2161	toxin-antitoxin pair type II binding
I6J41_RS13145	COG4115	mRNA cleavage
I6J41_RS13160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J41_RS13165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J41_RS13170	COG0084	hydrolase, TatD family'
I6J41_RS13200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J41_RS13245	COG2223	nitrite transmembrane transporter activity
I6J41_RS13250	COG2207	Transcriptional regulator
I6J41_RS13255	COG0442	prolyl-tRNA aminoacylation
I6J41_RS13275	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I6J41_RS13280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J41_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS13305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J41_RS13315	COG2409	Drug exporters of the RND superfamily
I6J41_RS13325	COG0793	Belongs to the peptidase S41A family
I6J41_RS13325	COG4946	Tricorn protease homolog
I6J41_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS13345	COG2072	flavoprotein involved in K transport
I6J41_RS13355	COG0708	Exodeoxyribonuclease III
I6J41_RS13385	COG2340	Cysteine-rich secretory protein family
I6J41_RS13405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J41_RS13425	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J41_RS13430	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J41_RS13440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J41_RS13445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J41_RS13470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J41_RS13495	COG0437	4 iron, 4 sulfur cluster binding
I6J41_RS13500	COG0243	molybdopterin cofactor binding
I6J41_RS13520	COG0477	Major facilitator Superfamily
I6J41_RS13540	COG3384	dioxygenase
I6J41_RS13545	COG1846	Transcriptional regulator
I6J41_RS13565	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS13625	COG1686	Belongs to the peptidase S11 family
I6J41_RS13730	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J41_RS13745	COG3386	PFAM SMP-30 Gluconolaconase
I6J41_RS13750	COG0768	penicillin binding
I6J41_RS13850	COG0739	heme binding
I6J41_RS13850	COG0741	lytic transglycosylase activity
I6J41_RS13850	COG1196	nuclear chromosome segregation
I6J41_RS13870	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
I6J41_RS13880	COG0183	Belongs to the thiolase family
I6J41_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS13900	COG2208	phosphoserine phosphatase activity
I6J41_RS13900	COG2770	Histidine kinase
I6J41_RS13920	COG1309	transcriptional regulator
I6J41_RS13930	COG1301	dicarboxylic acid transport
I6J41_RS13940	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J41_RS13950	COG0163	prenyltransferase activity
I6J41_RS13965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J41_RS13975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J41_RS13980	COG1333	cytochrome c biogenesis protein
I6J41_RS13985	COG0785	Cytochrome C biogenesis protein
I6J41_RS13990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J41_RS14000	COG0406	alpha-ribazole phosphatase activity
I6J41_RS14005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J41_RS14035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J41_RS14040	COG1690	Belongs to the RtcB family
I6J41_RS14065	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6J41_RS14070	COG0018	arginyl-trna synthetase
I6J41_RS14110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J41_RS14150	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS14160	COG0515	serine threonine protein kinase
I6J41_RS14200	COG2267	carboxylic ester hydrolase activity
I6J41_RS14240	COG0671	phosphoesterase, PA-phosphatase related
I6J41_RS14255	COG0667	Aldo Keto reductase
I6J41_RS14260	COG1309	transcriptional regulator
I6J41_RS14290	COG2252	PERMEase
I6J41_RS14300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J41_RS14320	COG2814	Major facilitator Superfamily
I6J41_RS14330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J41_RS14335	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J41_RS14345	COG1278	Cold shock
I6J41_RS14370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS14375	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS14380	COG1120	ATPase activity
I6J41_RS14385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J41_RS14435	COG1061	Type III restriction enzyme res subunit
I6J41_RS14445	COG1120	ATPase activity
I6J41_RS14475	COG3973	AAA domain
I6J41_RS14495	COG1984	allophanate hydrolase subunit 2
I6J41_RS14505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J41_RS14515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J41_RS14520	COG0640	Transcriptional regulator
I6J41_RS14525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J41_RS14545	COG1737	Transcriptional regulator
I6J41_RS14550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J41_RS14575	COG4257	antibiotic catabolic process
I6J41_RS14595	COG2204	response regulator
I6J41_RS14600	COG4251	negative regulation of phosphorylation
I6J41_RS14640	COG1175	transmembrane transport
I6J41_RS14645	COG0395	ABC-type sugar transport system, permease component
I6J41_RS14665	COG2318	DinB family
I6J41_RS14680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J41_RS14685	COG0546	phosphoglycolate phosphatase activity
I6J41_RS14745	COG1595	DNA-templated transcription, initiation
I6J41_RS14750	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J41_RS14750	COG2319	Wd-40 repeat
I6J41_RS14765	COG1132	(ABC) transporter
I6J41_RS14815	COG0463	Glycosyl transferase, family 2
I6J41_RS14830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6J41_RS14855	COG2197	response regulator
I6J41_RS14895	COG1136	(ABC) transporter
I6J41_RS14895	COG0577	efflux transmembrane transporter activity
I6J41_RS14905	COG2197	response regulator
I6J41_RS14950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J41_RS14955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J41_RS14960	COG1754	DNA topoisomerase type I activity
I6J41_RS14960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J41_RS14970	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J41_RS14980	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J41_RS14990	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS14995	COG1205	dead DEAH box helicase
I6J41_RS14995	COG1111	helicase
I6J41_RS15055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J41_RS15060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J41_RS15070	COG2267	carboxylic ester hydrolase activity
I6J41_RS15095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J41_RS15105	COG0251	oxidation-reduction process
I6J41_RS15120	COG0003	Pfam Anion-transporting ATPase
I6J41_RS15130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J41_RS15135	COG1610	YqeY-like protein
I6J41_RS15140	COG1408	metallophosphoesterase
I6J41_RS15155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J41_RS15160	COG2755	lipolytic protein G-D-S-L family
I6J41_RS15170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J41_RS15190	COG1595	DNA-templated transcription, initiation
I6J41_RS15220	COG0702	epimerase
I6J41_RS15230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J41_RS15235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J41_RS15250	COG1802	Transcriptional regulator
I6J41_RS15255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J41_RS15260	COG0693	protein deglycase activity
I6J41_RS15270	COG2124	cytochrome p450
I6J41_RS15280	COG0738	Major facilitator superfamily
I6J41_RS15285	COG3226	Transcriptional regulator
I6J41_RS15290	COG0667	Aldo Keto reductase
I6J41_RS15315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS15325	COG0662	Cupin 2, conserved barrel domain protein
I6J41_RS15330	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS15385	COG0590	tRNA wobble adenosine to inosine editing
I6J41_RS15395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J41_RS15425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J41_RS15445	COG2124	cytochrome p450
I6J41_RS15450	COG2197	response regulator
I6J41_RS15455	COG4585	Histidine kinase
I6J41_RS15460	COG0702	epimerase
I6J41_RS15470	COG3844	kynureninase activity
I6J41_RS15485	COG0477	Major facilitator Superfamily
I6J41_RS15490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J41_RS15495	COG0191	fructose-bisphosphate aldolase activity
I6J41_RS15500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J41_RS15515	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6J41_RS15540	COG0542	response to heat
I6J41_RS15585	COG0789	Transcriptional regulator
I6J41_RS15590	COG0484	heat shock protein binding
I6J41_RS15595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J41_RS15600	COG0443	Heat shock 70 kDa protein
I6J41_RS15605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J41_RS15610	COG2181	nitrate reductase activity
I6J41_RS15610	COG0247	lactate metabolic process
I6J41_RS15630	COG0717	Belongs to the dCTP deaminase family
I6J41_RS15670	COG3209	COG3209 Rhs family protein
I6J41_RS15690	COG1309	transcriptional regulator
I6J41_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS15700	COG1278	Cold shock
I6J41_RS15770	COG2205	protein histidine kinase activity
I6J41_RS15775	COG0745	RESPONSE REGULATOR receiver
I6J41_RS15840	COG2409	Drug exporters of the RND superfamily
I6J41_RS15850	COG0513	Belongs to the DEAD box helicase family
I6J41_RS15855	COG1278	Cold shock
I6J41_RS15905	COG0450	alkyl hydroperoxide reductase
I6J41_RS15915	COG2268	Band 7 protein
I6J41_RS15965	COG0490	domain, Protein
I6J41_RS15970	COG0475	glutathione-regulated potassium exporter activity
I6J41_RS15975	COG0181	hydroxymethylbilane synthase activity
I6J41_RS16000	COG2255	four-way junction helicase activity
I6J41_RS16010	COG0180	Tryptophanyl-tRNA synthetase
I6J41_RS16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS16050	COG0431	NADPH-dependent FMN reductase
I6J41_RS16075	COG2304	oxidoreductase activity
I6J41_RS16080	COG2205	protein histidine kinase activity
I6J41_RS16085	COG0745	RESPONSE REGULATOR receiver
I6J41_RS16090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J41_RS16105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J41_RS16120	COG1741	Belongs to the pirin family
I6J41_RS16130	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS16140	COG1362	aminopeptidase activity
I6J41_RS16150	COG3629	intracellular signal transduction
I6J41_RS16150	COG3903	Transcriptional regulator
I6J41_RS16175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J41_RS16185	COG2271	Major facilitator Superfamily
I6J41_RS16190	COG1802	Transcriptional regulator
I6J41_RS16200	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J41_RS16205	COG0022	dehydrogenase e1 component
I6J41_RS16230	COG0515	serine threonine protein kinase
I6J41_RS16235	COG0515	serine threonine protein kinase
I6J41_RS16250	COG1136	(ABC) transporter
I6J41_RS16250	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J41_RS16275	COG0303	'Molybdopterin
I6J41_RS16300	COG1522	sequence-specific DNA binding
I6J41_RS16305	COG1309	transcriptional regulator
I6J41_RS16330	COG3396	Phenylacetate-CoA oxygenase
I6J41_RS16335	COG3460	Phenylacetate-CoA oxygenase
I6J41_RS16340	COG3396	Phenylacetate-CoA oxygenase
I6J41_RS16345	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J41_RS16350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J41_RS16385	COG1716	ATPase activity
I6J41_RS16390	COG1716	ATPase activity
I6J41_RS16405	COG0768	penicillin binding
I6J41_RS16410	COG0515	serine threonine protein kinase
I6J41_RS16415	COG3764	Sortase (surface protein transpeptidase)
I6J41_RS16420	COG3764	Sortase (surface protein transpeptidase)
I6J41_RS16435	COG3764	Sortase (surface protein transpeptidase)
I6J41_RS16470	COG2226	methyltransferase
I6J41_RS16555	COG0515	serine threonine protein kinase
I6J41_RS16585	COG0582	viral genome integration into host DNA
I6J41_RS16590	COG0582	viral genome integration into host DNA
I6J41_RS17020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J41_RS17030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J41_RS17035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J41_RS17040	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J41_RS17045	COG0592	DNA-directed DNA polymerase activity
I6J41_RS17060	COG0594	ribonuclease P activity
I6J41_RS17065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J41_RS17070	COG0706	membrane insertase activity
I6J41_RS17080	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J41_RS17085	COG1192	Involved in chromosome partitioning
I6J41_RS17100	COG3118	belongs to the thioredoxin family
I6J41_RS17105	COG0492	ferredoxin-NADP+ reductase activity
I6J41_RS17115	COG1595	DNA-templated transcription, initiation
I6J41_RS17120	COG0515	serine threonine protein kinase
I6J41_RS17120	COG2815	serine threonine protein kinase
I6J41_RS17135	COG0617	tRNA 3'-terminal CCA addition
I6J41_RS17155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J41_RS17180	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J41_RS17185	COG0629	single-stranded DNA binding
I6J41_RS17190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J41_RS17195	COG0359	binds to the 23S rRNA
I6J41_RS17205	COG0305	Participates in initiation and elongation during chromosome replication
I6J41_RS17230	COG2814	Major facilitator Superfamily
I6J41_RS17245	COG0626	cystathionine gamma-synthase activity
I6J41_RS17250	COG1950	PFAM Membrane protein of
I6J41_RS17255	COG0662	Cupin 2, conserved barrel domain protein
I6J41_RS17280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J41_RS17290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J41_RS17295	COG1609	Transcriptional regulator
I6J41_RS17300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J41_RS17305	COG1271	oxidase subunit
I6J41_RS17310	COG1294	oxidase, subunit
I6J41_RS17315	COG4988	ABC transporter
I6J41_RS17325	COG0561	phosphatase activity
I6J41_RS17335	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J41_RS17340	COG0789	Transcriptional regulator
I6J41_RS17355	COG1131	(ABC) transporter
I6J41_RS17380	COG0561	phosphatase activity
I6J41_RS17385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J41_RS17395	COG2837	iron assimilation
I6J41_RS17400	COG2372	response to copper ion
I6J41_RS17410	COG1999	signal sequence binding
I6J41_RS17430	COG0006	proline dipeptidase activity
I6J41_RS17445	COG0653	protein targeting
I6J41_RS17460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J41_RS17485	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS17510	COG1595	DNA-templated transcription, initiation
I6J41_RS17515	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS17550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J41_RS17575	COG0494	nUDIX hydrolase
I6J41_RS17595	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J41_RS17605	COG1252	NADH dehydrogenase
I6J41_RS17610	COG1595	DNA-templated transcription, initiation
I6J41_RS17630	COG0745	RESPONSE REGULATOR receiver
I6J41_RS17645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J41_RS17655	COG0477	Major facilitator Superfamily
I6J41_RS17670	COG3467	pyridoxamine 5'-phosphate
I6J41_RS17675	COG2353	YceI-like domain
I6J41_RS17700	COG1191	sigma factor activity
I6J41_RS17705	COG1191	sigma factor activity
I6J41_RS17745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J41_RS17760	COG2234	aminopeptidase activity
I6J41_RS17795	COG0464	growth
I6J41_RS17875	COG4941	Belongs to the sigma-70 factor family
I6J41_RS17925	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J41_RS18045	COG0492	ferredoxin-NADP+ reductase activity
I6J41_RS18070	COG0151	Belongs to the GarS family
I6J41_RS18085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J41_RS18095	COG2197	response regulator
I6J41_RS18110	COG1131	(ABC) transporter
I6J41_RS18130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J41_RS18135	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J41_RS18140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J41_RS18150	COG0739	heme binding
I6J41_RS18150	COG0741	lytic transglycosylase activity
I6J41_RS18150	COG1196	nuclear chromosome segregation
I6J41_RS18165	COG3119	arylsulfatase activity
I6J41_RS18175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J41_RS18185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J41_RS18205	COG1643	Atp-dependent helicase
I6J41_RS18215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J41_RS18215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J41_RS18220	COG0785	Cytochrome C biogenesis protein
I6J41_RS18255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J41_RS18265	COG0513	Belongs to the DEAD box helicase family
I6J41_RS18275	COG0596	Alpha beta hydrolase
I6J41_RS18280	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS18290	COG0596	Alpha beta hydrolase
I6J41_RS18300	COG1191	sigma factor activity
I6J41_RS18315	COG1937	Protein conserved in bacteria
I6J41_RS18330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J41_RS18330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J41_RS18335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J41_RS18340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J41_RS18360	COG0741	lytic transglycosylase activity
I6J41_RS18360	COG0739	heme binding
I6J41_RS18360	COG1196	nuclear chromosome segregation
I6J41_RS18375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J41_RS18380	COG0579	oxidoreductase
I6J41_RS18405	COG1252	NADH dehydrogenase
I6J41_RS18420	COG1846	Transcriptional regulator
I6J41_RS18440	COG2197	response regulator
I6J41_RS18445	COG4585	Histidine kinase
I6J41_RS18525	COG0741	lytic transglycosylase activity
I6J41_RS18525	COG1196	nuclear chromosome segregation
I6J41_RS18525	COG0739	heme binding
I6J41_RS18530	COG0671	phosphoesterase, PA-phosphatase related
I6J41_RS18550	COG1937	Protein conserved in bacteria
I6J41_RS18560	COG0306	phosphate transporter
I6J41_RS18580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J41_RS18585	COG0494	nUDIX hydrolase
I6J41_RS18585	COG0406	alpha-ribazole phosphatase activity
I6J41_RS18605	COG1725	Transcriptional regulator
I6J41_RS18615	COG0456	acetyltransferase
I6J41_RS18625	COG0737	Belongs to the 5'-nucleotidase family
I6J41_RS18630	COG4106	trans-aconitate 2-methyltransferase activity
I6J41_RS18655	COG0154	amidase activity
I6J41_RS18670	COG4977	sequence-specific DNA binding
I6J41_RS18685	COG0739	heme binding
I6J41_RS18720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J41_RS18730	COG0745	RESPONSE REGULATOR receiver
I6J41_RS18755	COG2897	thiosulfate sulfurtransferase activity
I6J41_RS18775	COG3485	protocatechuate 3,4-dioxygenase
I6J41_RS18780	COG0735	belongs to the Fur family
I6J41_RS18790	COG1490	D-aminoacyl-tRNA deacylase activity
I6J41_RS18805	COG4552	Acetyltransferase involved in intracellular survival and related
I6J41_RS18845	COG4942	peptidase
I6J41_RS18915	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS18970	COG0640	Transcriptional regulator
I6J41_RS18975	COG0798	PFAM Bile acid sodium symporter
I6J41_RS18980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J41_RS18990	COG0588	phosphoglycerate mutase activity
I6J41_RS19010	COG5002	protein histidine kinase activity
I6J41_RS19025	COG1329	Transcriptional regulator
I6J41_RS19030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J41_RS19035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J41_RS19050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS19060	COG3467	pyridoxamine 5'-phosphate
I6J41_RS19065	COG0215	cysteine-tRNA ligase activity
I6J41_RS19090	COG3842	ATPase activity
I6J41_RS19150	COG0745	RESPONSE REGULATOR receiver
I6J41_RS19195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J41_RS19215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J41_RS19235	COG2197	response regulator
I6J41_RS19270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J41_RS19295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J41_RS19305	COG1653	transport
I6J41_RS19365	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS19395	COG0076	glutamate decarboxylase activity
I6J41_RS19400	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J41_RS19410	COG0393	Putative heavy-metal-binding
I6J41_RS19415	COG0586	Pfam SNARE associated Golgi protein
I6J41_RS19425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J41_RS19430	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J41_RS19440	COG0037	tRNA processing
I6J41_RS19455	COG0302	gtp cyclohydrolase
I6J41_RS19470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J41_RS19485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J41_RS19485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J41_RS19495	COG1125	glycine betaine transport
I6J41_RS19495	COG0517	IMP dehydrogenase activity
I6J41_RS19500	COG1174	glycine betaine transport
I6J41_RS19505	COG1174	glycine betaine transport
I6J41_RS19520	COG0649	NAD binding
I6J41_RS19535	COG2197	response regulator
I6J41_RS19540	COG1660	Displays ATPase and GTPase activities
I6J41_RS19565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J41_RS19570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J41_RS19580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J41_RS19600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J41_RS19630	COG0739	heme binding
I6J41_RS19635	COG2205	protein histidine kinase activity
I6J41_RS19640	COG0745	RESPONSE REGULATOR receiver
I6J41_RS19650	COG1595	DNA-templated transcription, initiation
I6J41_RS19655	COG1194	a g-specific adenine glycosylase
I6J41_RS19665	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6J41_RS19685	COG0248	Ppx GppA phosphatase
I6J41_RS19690	COG1082	Xylose isomerase domain protein TIM barrel
I6J41_RS19700	COG0129	dihydroxy-acid dehydratase activity
I6J41_RS19705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J41_RS19705	COG0515	serine threonine protein kinase
I6J41_RS19710	COG4991	sh3 domain protein
I6J41_RS19720	COG1129	ABC transporter
I6J41_RS19720	COG0842	Transport permease protein
I6J41_RS19730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J41_RS19750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS19810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J41_RS19815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J41_RS19820	COG0181	hydroxymethylbilane synthase activity
I6J41_RS19825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J41_RS19825	COG1648	precorrin-2 dehydrogenase activity
I6J41_RS19830	COG0113	porphobilinogen synthase activity
I6J41_RS19865	COG2318	DinB family
I6J41_RS19900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J41_RS19925	COG2161	toxin-antitoxin pair type II binding
I6J41_RS19965	COG1136	(ABC) transporter
I6J41_RS19965	COG0577	efflux transmembrane transporter activity
I6J41_RS19985	COG0745	RESPONSE REGULATOR receiver
I6J41_RS19990	COG2205	protein histidine kinase activity
I6J41_RS20010	COG1309	transcriptional regulator
I6J41_RS20070	COG1335	isochorismatase
I6J41_RS20085	COG2318	DinB family
I6J41_RS20095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J41_RS20125	COG2205	protein histidine kinase activity
I6J41_RS20130	COG0277	FAD linked oxidase domain protein
I6J41_RS20130	COG0247	lactate metabolic process
I6J41_RS20135	COG0583	DNA-binding transcription factor activity
I6J41_RS20140	COG5006	permease, DMT superfamily
I6J41_RS20145	COG4221	oxidoreductase activity
I6J41_RS20150	COG1309	transcriptional regulator
I6J41_RS20175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J41_RS20190	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS20195	COG1024	Enoyl-CoA hydratase
I6J41_RS20260	COG1396	sequence-specific DNA binding
I6J41_RS20280	COG0259	pyridoxamine-phosphate oxidase activity
I6J41_RS20290	COG4821	SIS domain
I6J41_RS20345	COG0604	alcohol dehydrogenase
I6J41_RS20375	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS20385	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS20395	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS20400	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS20420	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS20460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J41_RS20465	COG1024	Enoyl-CoA hydratase
I6J41_RS20490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J41_RS20500	COG2072	flavoprotein involved in K transport
I6J41_RS20515	COG2124	cytochrome p450
I6J41_RS20530	COG0501	Belongs to the peptidase M48B family
I6J41_RS20555	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS20565	COG1309	transcriptional regulator
I6J41_RS20590	COG1024	Enoyl-CoA hydratase
I6J41_RS20605	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS20640	COG0789	Transcriptional regulator
I6J41_RS20645	COG1278	Cold shock
I6J41_RS20650	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J41_RS20660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J41_RS20685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J41_RS20690	COG4521	taurine ABC transporter
I6J41_RS20700	COG2175	clavaminate synthase activity
I6J41_RS20705	COG2226	methyltransferase
I6J41_RS20770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS20775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS20780	COG0649	NAD binding
I6J41_RS20790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J41_RS20795	COG1034	ATP synthesis coupled electron transport
I6J41_RS20800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J41_RS20805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS20810	COG0839	Belongs to the complex I subunit 6 family
I6J41_RS20815	COG0713	ATP synthesis coupled electron transport
I6J41_RS20820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J41_RS20830	COG1007	ATP synthesis coupled electron transport
I6J41_RS20835	COG0514	ATP-dependent DNA helicase (RecQ)
I6J41_RS20870	COG3104	oligopeptide transport
I6J41_RS20875	COG0142	geranyltranstransferase activity
I6J41_RS20900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J41_RS20900	COG0515	serine threonine protein kinase
I6J41_RS20915	COG0789	Transcriptional regulator
I6J41_RS20920	COG4221	oxidoreductase activity
I6J41_RS20940	COG0561	phosphatase activity
I6J41_RS20955	COG0667	Aldo Keto reductase
I6J41_RS21045	COG0702	epimerase
I6J41_RS21050	COG1733	regulation of RNA biosynthetic process
I6J41_RS21055	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J41_RS21060	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J41_RS21060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J41_RS21075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS21085	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS21090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J41_RS21095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J41_RS21100	COG0839	Belongs to the complex I subunit 6 family
I6J41_RS21105	COG0713	ATP synthesis coupled electron transport
I6J41_RS21110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J41_RS21120	COG1007	ATP synthesis coupled electron transport
I6J41_RS21125	COG1970	mechanosensitive ion channel activity
I6J41_RS21130	COG0501	Belongs to the peptidase M48B family
I6J41_RS21135	COG3304	Inner membrane component domain
I6J41_RS21150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J41_RS21155	COG1666	GTP binding
I6J41_RS21165	COG0702	epimerase
I6J41_RS21185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J41_RS21190	COG2030	dehydratase
I6J41_RS21210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J41_RS21215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J41_RS21220	COG0436	Aminotransferase
I6J41_RS21240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J41_RS21245	COG0081	regulation of translation
I6J41_RS21255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J41_RS21260	COG0222	ribosome binding
I6J41_RS21265	COG0085	RNA polymerase activity
I6J41_RS21270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J41_RS21275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J41_RS21355	COG0741	lytic transglycosylase activity
I6J41_RS21355	COG1196	nuclear chromosome segregation
I6J41_RS21355	COG0739	heme binding
I6J41_RS21370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J41_RS21375	COG0049	tRNA binding
I6J41_RS21380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J41_RS21385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J41_RS21390	COG4585	Histidine kinase
I6J41_RS21395	COG2197	response regulator
I6J41_RS21410	COG0051	transcription antitermination factor activity, RNA binding
I6J41_RS21415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J41_RS21420	COG0088	Forms part of the polypeptide exit tunnel
I6J41_RS21425	COG0089	rRNA binding
I6J41_RS21430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J41_RS21435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J41_RS21440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J41_RS21445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J41_RS21450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J41_RS21455	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J41_RS21460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J41_RS21465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J41_RS21470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J41_RS21475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J41_RS21480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J41_RS21485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J41_RS21490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J41_RS21495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J41_RS21500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J41_RS21505	COG1841	ribosomal large subunit assembly
I6J41_RS21510	COG0200	Binds to the 23S rRNA
I6J41_RS21520	COG0563	adenylate kinase activity
I6J41_RS21530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J41_RS21535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J41_RS21540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J41_RS21545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J41_RS21550	COG0202	RNA polymerase activity
I6J41_RS21555	COG0203	ribosomal protein L17
I6J41_RS21560	COG0101	tRNA pseudouridine synthase activity
I6J41_RS21570	COG0488	(ABC) transporter
I6J41_RS21575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J41_RS21580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J41_RS21585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J41_RS21595	COG1072	(Pantothenic acid kinase))
I6J41_RS21675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J41_RS21680	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J41_RS21690	COG3189	MarR family transcriptional regulator
I6J41_RS21705	COG0802	atpase or kinase
I6J41_RS21730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J41_RS21765	COG0726	polysaccharide deacetylase
I6J41_RS21775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J41_RS21790	COG2132	Multicopper oxidase
I6J41_RS21805	COG0583	DNA-binding transcription factor activity
I6J41_RS21820	COG1595	DNA-templated transcription, initiation
I6J41_RS21830	COG0516	GMP reductase activity
I6J41_RS21845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J41_RS21860	COG0515	serine threonine protein kinase
I6J41_RS21865	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS21885	COG0519	Catalyzes the synthesis of GMP from XMP
I6J41_RS21885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J41_RS21895	COG4106	trans-aconitate 2-methyltransferase activity
I6J41_RS21925	COG2197	response regulator
I6J41_RS21950	COG0739	heme binding
I6J41_RS21960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J41_RS21980	COG0714	Associated with various cellular activities
I6J41_RS21990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J41_RS21995	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J41_RS22025	COG0138	bifunctional purine biosynthesis protein purh
I6J41_RS22040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J41_RS22055	COG0039	L-malate dehydrogenase activity
I6J41_RS22075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J41_RS22080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J41_RS22090	COG0754	glutathionylspermidine amidase activity
I6J41_RS22095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J41_RS22100	COG0180	Tryptophanyl-tRNA synthetase
I6J41_RS22120	COG1295	ribonuclease BN
I6J41_RS22135	COG1408	metallophosphoesterase
I6J41_RS22170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J41_RS22175	COG1053	succinate dehydrogenase
I6J41_RS22185	COG2009	succinate dehydrogenase
I6J41_RS22235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J41_RS22240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J41_RS22245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J41_RS22285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J41_RS22290	COG1595	DNA-templated transcription, initiation
I6J41_RS22335	COG1216	Glycosyl transferase, family 2
I6J41_RS22345	COG1083	cytidylyl-transferase
I6J41_RS22350	COG2089	acid synthase
I6J41_RS22375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J41_RS22375	COG1473	amidohydrolase
I6J41_RS22380	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J41_RS22385	COG3845	ABC transporter
I6J41_RS22390	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J41_RS22395	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J41_RS22415	COG1404	Belongs to the peptidase S8 family
I6J41_RS22435	COG2814	Major facilitator Superfamily
I6J41_RS22440	COG0583	DNA-binding transcription factor activity
I6J41_RS22460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J41_RS22485	COG2205	protein histidine kinase activity
I6J41_RS22490	COG0745	RESPONSE REGULATOR receiver
I6J41_RS22495	COG1595	DNA-templated transcription, initiation
I6J41_RS22510	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS22530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J41_RS22560	COG4770	biotin carboxylase activity
I6J41_RS22570	COG0424	maF-like protein
I6J41_RS22580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J41_RS22595	COG1024	Enoyl-CoA hydratase
I6J41_RS22620	COG1376	ErfK ybiS ycfS ynhG family protein
I6J41_RS22640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J41_RS22650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J41_RS22655	COG0583	DNA-binding transcription factor activity
I6J41_RS22695	COG1595	DNA-templated transcription, initiation
I6J41_RS22700	COG0745	RESPONSE REGULATOR receiver
I6J41_RS22705	COG5002	protein histidine kinase activity
I6J41_RS22705	COG0784	Response regulator, receiver
I6J41_RS22705	COG2198	Histidine kinase
I6J41_RS22715	COG2172	sigma factor antagonist activity
I6J41_RS22720	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS22725	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J41_RS22735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J41_RS22750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J41_RS22760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J41_RS22785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J41_RS22805	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS22805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS22805	COG0300	oxidoreductase activity
I6J41_RS22805	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS22805	COG3321	synthase
I6J41_RS22805	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS22805	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS22805	COG3321	synthase
I6J41_RS22805	COG0300	oxidoreductase activity
I6J41_RS22805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS22810	COG3251	PFAM MbtH domain protein
I6J41_RS22840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J41_RS22845	COG2175	clavaminate synthase activity
I6J41_RS22850	COG2197	response regulator
I6J41_RS22855	COG1136	(ABC) transporter
I6J41_RS22855	COG0577	efflux transmembrane transporter activity
I6J41_RS22865	COG4585	Histidine kinase
I6J41_RS22895	COG0154	amidase activity
I6J41_RS22920	COG1331	Highly conserved protein containing a thioredoxin domain
I6J41_RS22930	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J41_RS22940	COG0436	Aminotransferase
I6J41_RS22960	COG1733	regulation of RNA biosynthetic process
I6J41_RS22980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J41_RS22995	COG1414	Transcriptional regulator
I6J41_RS23000	COG0251	oxidation-reduction process
I6J41_RS23005	COG2610	gluconate transmembrane transporter activity
I6J41_RS23030	COG2894	cell division
I6J41_RS23065	COG2197	response regulator
I6J41_RS23085	COG2885	chlorophyll binding
I6J41_RS23150	COG2226	methyltransferase
I6J41_RS23160	COG0667	Aldo Keto reductase
I6J41_RS23165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J41_RS23170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J41_RS23185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J41_RS23190	COG0450	alkyl hydroperoxide reductase
I6J41_RS23205	COG1136	(ABC) transporter
I6J41_RS23225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J41_RS23225	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J41_RS23240	COG0114	fumarate hydratase activity
I6J41_RS23250	COG1362	aminopeptidase activity
I6J41_RS23280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J41_RS23280	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J41_RS23305	COG0778	Nitroreductase
I6J41_RS23310	COG1722	exodeoxyribonuclease VII activity
I6J41_RS23315	COG1570	exodeoxyribonuclease VII activity
I6J41_RS23325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J41_RS23340	COG0012	GTP binding
I6J41_RS23350	COG0477	Major facilitator Superfamily
I6J41_RS23360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J41_RS23490	COG0789	Transcriptional regulator
I6J41_RS23545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J41_RS23560	COG2409	Drug exporters of the RND superfamily
I6J41_RS23565	COG4585	Histidine kinase
I6J41_RS23570	COG2197	response regulator
I6J41_RS23575	COG0154	amidase activity
I6J41_RS23590	COG1217	gtp-binding protein TYPA
I6J41_RS23600	COG0601	transmembrane transport
I6J41_RS23605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS23615	COG4608	Belongs to the ABC transporter superfamily
I6J41_RS23620	COG4166	transmembrane transport
I6J41_RS23625	COG0601	transmembrane transport
I6J41_RS23630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS23640	COG4608	Belongs to the ABC transporter superfamily
I6J41_RS23655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J41_RS23675	COG0110	maltose O-acetyltransferase activity
I6J41_RS23690	COG0515	serine threonine protein kinase
I6J41_RS23705	COG1132	(ABC) transporter
I6J41_RS23710	COG2197	response regulator
I6J41_RS23715	COG2912	Transglutaminase-like superfamily
I6J41_RS23745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J41_RS23750	COG1611	Belongs to the LOG family
I6J41_RS23755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J41_RS23765	COG0519	Catalyzes the synthesis of GMP from XMP
I6J41_RS23770	COG1024	Enoyl-CoA hydratase
I6J41_RS23785	COG1595	DNA-templated transcription, initiation
I6J41_RS23795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J41_RS23800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J41_RS23835	COG0598	Magnesium transport protein CorA
I6J41_RS23845	COG2814	Major facilitator Superfamily
I6J41_RS23860	COG2095	MarC family integral membrane protein
I6J41_RS23870	COG1432	Conserved Protein
I6J41_RS23880	COG0513	Belongs to the DEAD box helicase family
I6J41_RS23920	COG0747	negative chemotaxis
I6J41_RS23930	COG0601	transmembrane transport
I6J41_RS23935	COG4172	Belongs to the ABC transporter superfamily
I6J41_RS23980	COG0210	DNA helicase
I6J41_RS24080	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J41_RS24090	COG1615	UPF0182 protein
I6J41_RS24115	COG0753	catalase activity
I6J41_RS24125	COG0483	inositol monophosphate 1-phosphatase activity
I6J41_RS24135	COG2076	Multidrug Resistance protein
I6J41_RS24145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J41_RS24155	COG2135	peptidase activity
I6J41_RS24165	COG1595	DNA-templated transcription, initiation
I6J41_RS24170	COG5662	AntiSigma factor
I6J41_RS24180	COG0242	peptide deformylase activity
I6J41_RS24215	COG1966	Carbon starvation protein
I6J41_RS24220	COG2188	Transcriptional regulator
I6J41_RS24225	COG2182	Extracellular solute-binding protein
I6J41_RS24230	COG1175	transmembrane transport
I6J41_RS24235	COG0395	ABC-type sugar transport system, permease component
I6J41_RS24240	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J41_RS24245	COG0363	glucosamine-6-phosphate deaminase activity
I6J41_RS24250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J41_RS24265	COG1597	lipid kinase activity
I6J41_RS24305	COG1959	2 iron, 2 sulfur cluster binding
I6J41_RS24310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J41_RS24315	COG0142	geranyltranstransferase activity
I6J41_RS24380	COG2197	response regulator
I6J41_RS24385	COG4585	Histidine kinase
I6J41_RS24405	COG1695	Transcriptional regulator
I6J41_RS24440	COG0242	peptide deformylase activity
I6J41_RS24465	COG4106	trans-aconitate 2-methyltransferase activity
I6J41_RS24470	COG1595	DNA-templated transcription, initiation
I6J41_RS24480	COG1126	abc transporter atp-binding protein
I6J41_RS24485	COG0765	amino acid transport
I6J41_RS24490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS24495	COG0281	malic enzyme
I6J41_RS24500	COG0604	alcohol dehydrogenase
I6J41_RS24520	COG0542	response to heat
I6J41_RS24545	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J41_RS24545	COG0567	Dehydrogenase, E1 component
I6J41_RS24550	COG2205	protein histidine kinase activity
I6J41_RS24555	COG0745	RESPONSE REGULATOR receiver
I6J41_RS24565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J41_RS24570	COG0726	polysaccharide deacetylase
I6J41_RS24630	COG1309	transcriptional regulator
I6J41_RS24680	COG2205	protein histidine kinase activity
I6J41_RS24700	COG1793	dna ligase
I6J41_RS24700	COG3285	dna ligase
I6J41_RS24705	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J41_RS24710	COG0515	serine threonine protein kinase
I6J41_RS24720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J41_RS24745	COG0018	arginyl-trna synthetase
I6J41_RS24750	COG0019	diaminopimelate decarboxylase activity
I6J41_RS24755	COG0460	homoserine dehydrogenase
I6J41_RS24760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J41_RS24765	COG0083	homoserine kinase activity
I6J41_RS24775	COG1316	TRANSCRIPTIONal
I6J41_RS24780	COG0254	rRNA binding
I6J41_RS24785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J41_RS24790	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J41_RS24800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J41_RS24805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J41_RS24825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J41_RS24830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J41_RS24835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J41_RS24840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J41_RS24845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J41_RS24850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J41_RS24855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J41_RS24870	COG2197	response regulator
I6J41_RS24875	COG4585	Histidine kinase
I6J41_RS24905	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS24920	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J41_RS24975	COG0183	Belongs to the thiolase family
I6J41_RS24990	COG0745	RESPONSE REGULATOR receiver
I6J41_RS24995	COG5000	phosphorelay sensor kinase activity
I6J41_RS24995	COG5002	protein histidine kinase activity
I6J41_RS25065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J41_RS25065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J41_RS25110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J41_RS25115	COG0280	phosphate acetyltransferase
I6J41_RS25115	COG0857	belongs to the CobB CobQ family
I6J41_RS25120	COG0205	6-phosphofructokinase activity
I6J41_RS25130	COG4565	transcriptional regulatory protein
I6J41_RS25135	COG3290	protein histidine kinase activity
I6J41_RS25140	COG1301	dicarboxylic acid transport
I6J41_RS25165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J41_RS25175	COG0366	Alpha amylase catalytic
I6J41_RS25180	COG0366	Alpha amylase catalytic
I6J41_RS25185	COG0058	SHG alpha-glucan phosphorylase activity
I6J41_RS25205	COG0387	Pfam Sodium calcium exchanger
I6J41_RS25225	COG1742	UPF0060 membrane protein
I6J41_RS25230	COG1132	(ABC) transporter
I6J41_RS25240	COG1131	(ABC) transporter
I6J41_RS25255	COG2197	response regulator
I6J41_RS25305	COG0515	serine threonine protein kinase
I6J41_RS25405	COG1506	peptidase
I6J41_RS25405	COG0823	Involved in the tonB-independent uptake of proteins
I6J41_RS25415	COG0464	growth
I6J41_RS25445	COG1760	l-serine dehydratase
I6J41_RS25450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J41_RS25455	COG0509	glycine decarboxylation via glycine cleavage system
I6J41_RS25460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J41_RS25480	COG0747	negative chemotaxis
I6J41_RS25485	COG0601	transmembrane transport
I6J41_RS25490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS25500	COG4608	Belongs to the ABC transporter superfamily
I6J41_RS25505	COG2860	membrane
I6J41_RS25515	COG2378	regulation of single-species biofilm formation
I6J41_RS25545	COG0482	sulfurtransferase activity
I6J41_RS25565	COG4221	oxidoreductase activity
I6J41_RS25575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J41_RS25585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J41_RS25590	COG0154	amidase activity
I6J41_RS25600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J41_RS25605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J41_RS25615	COG2409	Drug exporters of the RND superfamily
I6J41_RS25630	COG2197	response regulator
I6J41_RS25640	COG2133	pyrroloquinoline quinone binding
I6J41_RS25645	COG0667	Aldo Keto reductase
I6J41_RS25655	COG5001	Diguanylate cyclase
I6J41_RS25655	COG3300	MHYT domain
I6J41_RS25665	COG0440	acetolactate synthase activity
I6J41_RS25670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J41_RS25675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J41_RS25695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J41_RS25705	COG2508	Transcriptional regulator
I6J41_RS25710	COG0506	proline dehydrogenase activity
I6J41_RS25715	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS25720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J41_RS25720	COG0778	Nitroreductase
I6J41_RS25735	COG0473	3-isopropylmalate dehydrogenase activity
I6J41_RS25740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J41_RS25750	COG2957	Belongs to the agmatine deiminase family
I6J41_RS25760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J41_RS25765	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J41_RS25775	COG0542	response to heat
I6J41_RS25800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J41_RS25815	COG3708	Transcriptional regulator
I6J41_RS25815	COG2207	Transcriptional regulator
I6J41_RS25835	COG0492	ferredoxin-NADP+ reductase activity
I6J41_RS25880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS25885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS25890	COG1120	ATPase activity
I6J41_RS25895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J41_RS25900	COG2353	YceI-like domain
I6J41_RS25915	COG0366	Alpha amylase catalytic
I6J41_RS25915	COG1470	cell adhesion involved in biofilm formation
I6J41_RS25920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J41_RS25940	COG2018	Roadblock/LC7 domain
I6J41_RS25960	COG2018	Roadblock/LC7 domain
I6J41_RS25965	COG5002	protein histidine kinase activity
I6J41_RS25975	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J41_RS25980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J41_RS26025	COG1414	Transcriptional regulator
I6J41_RS26030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J41_RS26035	COG0066	3-isopropylmalate dehydratase activity
I6J41_RS26045	COG0776	regulation of translation
I6J41_RS26055	COG1920	GTP binding
I6J41_RS26065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J41_RS26070	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J41_RS26090	COG0351	phosphomethylpyrimidine kinase
I6J41_RS26095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J41_RS26100	COG1461	Dihydroxyacetone kinase
I6J41_RS26110	COG0742	ribosomal rna small subunit methyltransferase
I6J41_RS26115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J41_RS26130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J41_RS26135	COG0571	ribonuclease III activity
I6J41_RS26140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J41_RS26145	COG1733	regulation of RNA biosynthetic process
I6J41_RS26150	COG2340	Cysteine-rich secretory protein family
I6J41_RS26155	COG1254	Belongs to the acylphosphatase family
I6J41_RS26165	COG1196	nuclear chromosome segregation
I6J41_RS26170	COG0477	Major facilitator Superfamily
I6J41_RS26205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J41_RS26225	COG0228	four-way junction DNA binding
I6J41_RS26230	COG1837	Belongs to the UPF0109 family
I6J41_RS26235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J41_RS26240	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J41_RS26245	COG0335	large ribosomal subunit rRNA binding
I6J41_RS26260	COG0681	Belongs to the peptidase S26 family
I6J41_RS26270	COG1051	belongs to the nudix hydrolase family
I6J41_RS26280	COG0792	nuclease activity
I6J41_RS26325	COG3800	Transcriptional regulator
I6J41_RS26325	COG1396	sequence-specific DNA binding
I6J41_RS26385	COG1191	sigma factor activity
I6J41_RS26400	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J41_RS26405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J41_RS26410	COG0528	UMP kinase activity
I6J41_RS26415	COG0233	cytoplasmic translational termination
I6J41_RS26420	COG0575	Belongs to the CDS family
I6J41_RS26505	COG2226	methyltransferase
I6J41_RS26510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J41_RS26525	COG3842	ATPase activity
I6J41_RS26540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J41_RS26550	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS26575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J41_RS26615	COG1595	DNA-templated transcription, initiation
I6J41_RS26645	COG3842	ATPase activity
I6J41_RS26650	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J41_RS26655	COG1177	transmembrane transport
I6J41_RS26660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J41_RS26690	COG2508	Transcriptional regulator
I6J41_RS26700	COG2814	Major facilitator Superfamily
I6J41_RS26705	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS26715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J41_RS26720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J41_RS26725	COG0750	zinc metalloprotease
I6J41_RS26730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J41_RS26745	COG0442	prolyl-tRNA aminoacylation
I6J41_RS26765	COG0779	Required for maturation of 30S ribosomal subunits
I6J41_RS26780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J41_RS26790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J41_RS26795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J41_RS26830	COG4608	Belongs to the ABC transporter superfamily
I6J41_RS26840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS26845	COG0601	transmembrane transport
I6J41_RS26850	COG0747	negative chemotaxis
I6J41_RS26880	COG1404	Belongs to the peptidase S8 family
I6J41_RS26895	COG1404	Belongs to the peptidase S8 family
I6J41_RS26910	COG1674	ftsk spoiiie
I6J41_RS26920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J41_RS26925	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J41_RS26930	COG0612	Peptidase, M16
I6J41_RS26935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J41_RS26955	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J41_RS26960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J41_RS26965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J41_RS26995	COG2205	protein histidine kinase activity
I6J41_RS26995	COG3437	response regulator, receiver
I6J41_RS26995	COG3850	Histidine kinase
I6J41_RS26995	COG4999	Histidine kinase
I6J41_RS27005	COG1674	ftsk spoiiie
I6J41_RS27015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J41_RS27025	COG1546	Belongs to the CinA family
I6J41_RS27025	COG1058	Belongs to the CinA family
I6J41_RS27030	COG1396	sequence-specific DNA binding
I6J41_RS27035	COG0783	Belongs to the Dps family
I6J41_RS27045	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS27050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J41_RS27055	COG1201	RNA secondary structure unwinding
I6J41_RS27060	COG2207	Transcriptional regulator
I6J41_RS27060	COG1917	Cupin 2, conserved barrel domain protein
I6J41_RS27090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J41_RS27120	COG0765	amino acid transport
I6J41_RS27125	COG0765	amino acid transport
I6J41_RS27130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS27135	COG1126	abc transporter atp-binding protein
I6J41_RS27145	COG2205	protein histidine kinase activity
I6J41_RS27150	COG2358	TRAP transporter, solute receptor (TAXI family
I6J41_RS27155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J41_RS27170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J41_RS27180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J41_RS27185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J41_RS27195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J41_RS27235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J41_RS27240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J41_RS27245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J41_RS27275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J41_RS27310	COG2186	Transcriptional regulator
I6J41_RS27315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J41_RS27340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J41_RS27345	COG4565	transcriptional regulatory protein
I6J41_RS27350	COG3290	protein histidine kinase activity
I6J41_RS27355	COG0372	Belongs to the citrate synthase family
I6J41_RS27360	COG0372	Belongs to the citrate synthase family
I6J41_RS27370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J41_RS27375	COG0612	Peptidase, M16
I6J41_RS27390	COG1802	Transcriptional regulator
I6J41_RS27395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J41_RS27400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J41_RS27400	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J41_RS27400	COG1042	CoA-binding domain protein
I6J41_RS27415	COG1435	thymidine kinase activity
I6J41_RS27455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J41_RS27470	COG0745	RESPONSE REGULATOR receiver
I6J41_RS27475	COG2205	protein histidine kinase activity
I6J41_RS27500	COG0756	dUTP diphosphatase activity
I6J41_RS27510	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J41_RS27510	COG1136	(ABC) transporter
I6J41_RS27540	COG0569	domain protein
I6J41_RS27545	COG0531	amino acid
I6J41_RS27550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J41_RS27580	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J41_RS27585	COG4552	Acetyltransferase involved in intracellular survival and related
I6J41_RS27605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J41_RS27650	COG2814	Major facilitator Superfamily
I6J41_RS27665	COG0596	Alpha beta hydrolase
I6J41_RS27675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J41_RS27685	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J41_RS27695	COG3938	Belongs to the proline racemase family
I6J41_RS27705	COG2423	ornithine cyclodeaminase activity
I6J41_RS27710	COG1802	Transcriptional regulator
I6J41_RS27715	COG0006	proline dipeptidase activity
I6J41_RS27725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS27730	COG0601	transmembrane transport
I6J41_RS27745	COG3291	Pkd domain containing protein
I6J41_RS27755	COG1280	lysine exporter protein (LysE YggA)
I6J41_RS27760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J41_RS27765	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J41_RS27795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS27800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS27810	COG0586	Pfam SNARE associated Golgi protein
I6J41_RS27815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J41_RS27820	COG1349	DNA-binding transcription factor activity
I6J41_RS27825	COG1799	cell septum assembly
I6J41_RS27845	COG2040	homocysteine
I6J41_RS27855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J41_RS27865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J41_RS27870	COG0531	amino acid
I6J41_RS27880	COG1024	Enoyl-CoA hydratase
I6J41_RS27920	COG2111	Na H antiporter
I6J41_RS27920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J41_RS27925	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J41_RS27930	COG0651	ATP synthesis coupled electron transport
I6J41_RS27945	COG1320	monovalent cation:proton antiporter activity
I6J41_RS27960	COG0297	glycogen (starch) synthase activity
I6J41_RS27965	COG0489	protein tyrosine kinase activity
I6J41_RS28000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J41_RS28005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J41_RS28010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J41_RS28025	COG2197	response regulator
I6J41_RS28045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J41_RS28085	COG0477	Major facilitator Superfamily
I6J41_RS28090	COG3903	Transcriptional regulator
I6J41_RS28090	COG3629	intracellular signal transduction
I6J41_RS28105	COG0300	oxidoreductase activity
I6J41_RS28115	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS28140	COG0475	glutathione-regulated potassium exporter activity
I6J41_RS28160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS28175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J41_RS28205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J41_RS28210	COG0494	nUDIX hydrolase
I6J41_RS28230	COG0588	phosphoglycerate mutase activity
I6J41_RS28240	COG1653	transport
I6J41_RS28245	COG1175	transmembrane transport
I6J41_RS28250	COG0395	ABC-type sugar transport system, permease component
I6J41_RS28255	COG1940	carbohydrate kinase activity
I6J41_RS28260	COG4213	ABC transporter substrate-binding protein
I6J41_RS28270	COG4214	carbohydrate transport
I6J41_RS28275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J41_RS28280	COG0531	amino acid
I6J41_RS28305	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS28320	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS28320	COG1024	Enoyl-CoA hydratase
I6J41_RS28325	COG0183	Belongs to the thiolase family
I6J41_RS28350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J41_RS28365	COG0745	RESPONSE REGULATOR receiver
I6J41_RS28370	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J41_RS28380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J41_RS28385	COG3253	May function as heme-dependent peroxidase
I6J41_RS28400	COG3220	belongs to the UPF0276 family
I6J41_RS28415	COG4152	abc transporter atp-binding protein
I6J41_RS28435	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J41_RS28485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J41_RS28490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J41_RS28595	COG1063	alcohol dehydrogenase
I6J41_RS28600	COG0156	8-amino-7-oxononanoate synthase activity
I6J41_RS28605	COG0583	DNA-binding transcription factor activity
I6J41_RS28615	COG0346	lactoylglutathione lyase activity
I6J41_RS28620	COG1072	(Pantothenic acid kinase))
I6J41_RS28640	COG2723	6-phospho-beta-galactosidase activity
I6J41_RS28695	COG1175	transmembrane transport
I6J41_RS28715	COG1404	Belongs to the peptidase S8 family
I6J41_RS28735	COG1132	(ABC) transporter
I6J41_RS28740	COG1132	(ABC) transporter
I6J41_RS28745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J41_RS28750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS28755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS28760	COG1120	ATPase activity
I6J41_RS28765	COG2226	methyltransferase
I6J41_RS28775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J41_RS28780	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J41_RS28800	COG0529	Catalyzes the synthesis of activated sulfate
I6J41_RS28805	COG0175	sulfate reduction
I6J41_RS28840	COG3844	kynureninase activity
I6J41_RS28845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J41_RS28860	COG1917	Cupin 2, conserved barrel domain protein
I6J41_RS28885	COG0583	DNA-binding transcription factor activity
I6J41_RS28890	COG2814	Major facilitator Superfamily
I6J41_RS28910	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS28915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J41_RS28920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J41_RS28925	COG0583	DNA-binding transcription factor activity
I6J41_RS28930	COG0183	Belongs to the thiolase family
I6J41_RS28980	COG1162	GTPase activity
I6J41_RS29000	COG1404	Belongs to the peptidase S8 family
I6J41_RS29010	COG0028	Belongs to the TPP enzyme family
I6J41_RS29030	COG1802	Transcriptional regulator
I6J41_RS29055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J41_RS29060	COG2252	PERMEase
I6J41_RS29065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J41_RS29065	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J41_RS29090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS29120	COG0435	Glutathione S-transferase
I6J41_RS29135	COG2197	response regulator
I6J41_RS29140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J41_RS29145	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS29165	COG3960	tartronate-semialdehyde synthase activity
I6J41_RS29190	COG0753	catalase activity
I6J41_RS29195	COG2084	Dehydrogenase
I6J41_RS29200	COG3622	Belongs to the hyi family
I6J41_RS29205	COG2706	6-phosphogluconolactonase activity
I6J41_RS29225	COG2351	hydroxyisourate hydrolase activity
I6J41_RS29235	COG2233	PERMEase
I6J41_RS29245	COG2233	PERMEase
I6J41_RS29270	COG1288	antiporter activity
I6J41_RS29300	COG0242	peptide deformylase activity
I6J41_RS29305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J41_RS29320	COG2197	response regulator
I6J41_RS29340	COG1414	Transcriptional regulator
I6J41_RS29345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J41_RS29350	COG4266	Belongs to the allantoicase family
I6J41_RS29360	COG0656	L-ascorbic acid biosynthetic process
I6J41_RS29365	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS29385	COG2197	response regulator
I6J41_RS29400	COG0673	inositol 2-dehydrogenase activity
I6J41_RS29405	COG2188	Transcriptional regulator
I6J41_RS29420	COG1129	ABC transporter
I6J41_RS29425	COG1940	carbohydrate kinase activity
I6J41_RS29435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J41_RS29440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J41_RS29475	COG1126	abc transporter atp-binding protein
I6J41_RS29480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J41_RS29485	COG0765	amino acid transport
I6J41_RS29490	COG0765	amino acid transport
I6J41_RS29505	COG1024	Enoyl-CoA hydratase
I6J41_RS29505	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS29510	COG0183	Belongs to the thiolase family
I6J41_RS29520	COG0405	Gamma-glutamyltransferase
I6J41_RS29555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J41_RS29645	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS29665	COG0463	Glycosyl transferase, family 2
I6J41_RS29675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J41_RS29690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS29705	COG0175	sulfate reduction
I6J41_RS29710	COG2895	sulfate adenylyltransferase (ATP) activity
I6J41_RS29755	COG0626	cystathionine gamma-synthase activity
I6J41_RS29770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS29825	COG0095	Lipoate-protein ligase
I6J41_RS29845	COG1024	Enoyl-CoA hydratase
I6J41_RS29850	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS29870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J41_RS29885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J41_RS29930	COG1024	Enoyl-CoA hydratase
I6J41_RS29935	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS29965	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS29970	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS29975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J41_RS29980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J41_RS29990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS30000	COG1131	(ABC) transporter
I6J41_RS30005	COG1024	Enoyl-CoA hydratase
I6J41_RS30040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J41_RS30070	COG1929	Belongs to the glycerate kinase type-1 family
I6J41_RS30105	COG0688	phosphatidylethanolamine metabolic process
I6J41_RS30110	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS30120	COG2301	Belongs to the HpcH HpaI aldolase family
I6J41_RS30125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J41_RS30125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J41_RS30130	COG0604	alcohol dehydrogenase
I6J41_RS30150	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS30160	COG0596	Alpha beta hydrolase
I6J41_RS30190	COG0583	DNA-binding transcription factor activity
I6J41_RS30195	COG0667	Aldo Keto reductase
I6J41_RS30215	COG2362	D-Aminopeptidase
I6J41_RS30220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J41_RS30230	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J41_RS30285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J41_RS30300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J41_RS30300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J41_RS30310	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J41_RS30320	COG0702	epimerase
I6J41_RS30330	COG4106	trans-aconitate 2-methyltransferase activity
I6J41_RS30335	COG0300	oxidoreductase activity
I6J41_RS30365	COG0656	L-ascorbic acid biosynthetic process
I6J41_RS30380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J41_RS30385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J41_RS30395	COG1129	ABC transporter
I6J41_RS30400	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J41_RS30405	COG1879	ABC-type sugar transport system periplasmic component
I6J41_RS30410	COG0673	inositol 2-dehydrogenase activity
I6J41_RS30430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J41_RS30445	COG0084	hydrolase, TatD family'
I6J41_RS30525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS30525	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS30525	COG0300	oxidoreductase activity
I6J41_RS30525	COG3321	synthase
I6J41_RS30525	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS30530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J41_RS30545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS30550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS30555	COG3321	synthase
I6J41_RS30555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J41_RS30555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS30575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS30585	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS30610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J41_RS30615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS30620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J41_RS30625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J41_RS30630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS30650	COG0477	Major facilitator Superfamily
I6J41_RS30655	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS30665	COG1129	ABC transporter
I6J41_RS30670	COG1879	ABC-type sugar transport system periplasmic component
I6J41_RS30675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J41_RS30680	COG1869	D-ribose catabolic process
I6J41_RS30690	COG0714	Associated with various cellular activities
I6J41_RS30705	COG3568	Endonuclease Exonuclease Phosphatase
I6J41_RS30720	COG5002	protein histidine kinase activity
I6J41_RS30725	COG0745	RESPONSE REGULATOR receiver
I6J41_RS30755	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS30765	COG4175	Glycine betaine
I6J41_RS30765	COG0517	IMP dehydrogenase activity
I6J41_RS30770	COG4176	ABC-type proline glycine betaine transport system permease component
I6J41_RS30810	COG0488	(ABC) transporter
I6J41_RS30820	COG1070	Carbohydrate kinase
I6J41_RS30830	COG1940	carbohydrate kinase activity
I6J41_RS30880	COG2124	cytochrome p450
I6J41_RS30885	COG1486	melibiose metabolic process
I6J41_RS30915	COG3012	SEC-C Motif Domain Protein
I6J41_RS30940	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS30985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J41_RS31010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J41_RS31050	COG2326	polyphosphate kinase activity
I6J41_RS31055	COG1793	dna ligase
I6J41_RS31105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J41_RS31120	COG0488	(ABC) transporter
I6J41_RS31145	COG1515	deoxyribonuclease V activity
I6J41_RS31155	COG3268	Saccharopine dehydrogenase
I6J41_RS31160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J41_RS31165	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS31170	COG0183	Belongs to the thiolase family
I6J41_RS31175	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J41_RS31175	COG1024	Enoyl-CoA hydratase
I6J41_RS31180	COG0789	Transcriptional regulator
I6J41_RS31205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J41_RS31220	COG0488	(ABC) transporter
I6J41_RS31240	COG4977	sequence-specific DNA binding
I6J41_RS31250	COG1024	Enoyl-CoA hydratase
I6J41_RS31265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J41_RS31295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J41_RS31315	COG1134	teichoic acid transport
I6J41_RS31320	COG1562	ergosterol biosynthetic process
I6J41_RS31330	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J41_RS31340	COG1657	PFAM Prenyltransferase squalene oxidase
I6J41_RS31380	COG2755	lipolytic protein G-D-S-L family
I6J41_RS31390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J41_RS31430	COG3467	pyridoxamine 5'-phosphate
I6J41_RS31440	COG0789	Transcriptional regulator
I6J41_RS31495	COG3958	Transketolase
I6J41_RS31500	COG3959	Transketolase, thiamine diphosphate binding domain
I6J41_RS31510	COG0318	PFAM AMP-dependent synthetase and ligase
I6J41_RS31520	COG1733	regulation of RNA biosynthetic process
I6J41_RS31530	COG0789	Transcriptional regulator
I6J41_RS31545	COG3511	phospholipase C
I6J41_RS31555	COG2197	response regulator
I6J41_RS31560	COG3851	Histidine kinase
I6J41_RS31580	COG3293	Transposase
I6J41_RS31605	COG2197	response regulator
I6J41_RS31640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J41_RS31645	COG2423	ornithine cyclodeaminase activity
I6J41_RS31650	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS31655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J41_RS31690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J41_RS31705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS31730	COG1280	lysine exporter protein (LysE YggA)
I6J41_RS31785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J41_RS31785	COG1902	pentaerythritol trinitrate reductase activity
I6J41_RS31795	COG2409	Drug exporters of the RND superfamily
I6J41_RS31800	COG1846	Transcriptional regulator
I6J41_RS31850	COG2130	NADP-dependent
I6J41_RS31860	COG4948	Mandelate Racemase Muconate Lactonizing
I6J41_RS31865	COG0395	ABC-type sugar transport system, permease component
I6J41_RS31870	COG1175	transmembrane transport
I6J41_RS31885	COG2226	methyltransferase
I6J41_RS31900	COG3647	Membrane
I6J41_RS31905	COG2188	Transcriptional regulator
I6J41_RS31910	COG1742	UPF0060 membrane protein
I6J41_RS31925	COG1794	racemase activity, acting on amino acids and derivatives
I6J41_RS31955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J41_RS31965	COG0019	diaminopimelate decarboxylase activity
I6J41_RS31970	COG2837	iron assimilation
I6J41_RS31975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J41_RS31990	COG1119	ATPase activity
I6J41_RS32000	COG1595	DNA-templated transcription, initiation
I6J41_RS32030	COG0596	Alpha beta hydrolase
I6J41_RS32040	COG1028	Short-chain dehydrogenase reductase Sdr
I6J41_RS32050	COG1652	LysM domain
I6J41_RS32075	COG2208	phosphoserine phosphatase activity
I6J41_RS32085	COG0784	Response regulator, receiver
I6J41_RS32090	COG4251	negative regulation of phosphorylation
I6J41_RS32095	COG2201	protein-glutamate methylesterase activity
I6J41_RS32100	COG1191	sigma factor activity
I6J41_RS32140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J41_RS32155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J41_RS32160	COG3275	phosphorelay sensor kinase activity
I6J41_RS32230	COG0583	DNA-binding transcription factor activity
I6J41_RS32240	COG1053	succinate dehydrogenase
I6J41_RS32245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J41_RS32255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J41_RS32265	COG3360	Dodecin
I6J41_RS32270	COG1653	transport
I6J41_RS32285	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J41_RS32290	COG0121	glutamine amidotransferase
I6J41_RS32295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J41_RS32315	COG1609	Transcriptional regulator
I6J41_RS32325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J41_RS32330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J41_RS32350	COG0714	Associated with various cellular activities
I6J41_RS32370	COG1191	sigma factor activity
I6J41_RS32380	COG2045	Belongs to the ComB family
I6J41_RS32385	COG1834	amidinotransferase
I6J41_RS32395	COG1228	amidohydrolase
I6J41_RS32400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J41_RS32415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J41_RS32490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J41_RS32510	COG0463	Glycosyl transferase, family 2
I6J41_RS32575	COG0477	Major facilitator Superfamily
I6J41_RS32585	COG0254	rRNA binding
I6J41_RS32590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J41_RS32595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J41_RS32600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J41_RS32615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS32620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS32625	COG1120	ATPase activity
I6J41_RS32650	COG1132	(ABC) transporter
I6J41_RS32655	COG1132	(ABC) transporter
I6J41_RS32680	COG2304	oxidoreductase activity
I6J41_RS32700	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS32705	COG0726	polysaccharide deacetylase
I6J41_RS32725	COG0297	glycogen (starch) synthase activity
I6J41_RS32725	COG0438	transferase activity, transferring glycosyl groups
I6J41_RS32740	COG1174	glycine betaine transport
I6J41_RS32745	COG1174	glycine betaine transport
I6J41_RS32760	COG0517	IMP dehydrogenase activity
I6J41_RS32760	COG1125	glycine betaine transport
I6J41_RS32790	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS32795	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS32810	COG0601	transmembrane transport
I6J41_RS32815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J41_RS32820	COG0444	Belongs to the ABC transporter superfamily
I6J41_RS32920	COG1796	DNA polymerase
I6J41_RS32920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J41_RS32980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J41_RS33005	COG1278	Cold shock
I6J41_RS33010	COG0477	Major facilitator Superfamily
I6J41_RS33025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J41_RS33050	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J41_RS33070	COG1063	alcohol dehydrogenase
I6J41_RS33090	COG1349	DNA-binding transcription factor activity
I6J41_RS33110	COG0789	Transcriptional regulator
I6J41_RS33115	COG1960	acyl-CoA dehydrogenase activity
I6J41_RS33135	COG1012	belongs to the aldehyde dehydrogenase family
I6J41_RS33145	COG0385	Bile acid
I6J41_RS33190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J41_RS33230	COG0640	Transcriptional regulator
I6J41_RS33245	COG2018	Roadblock/LC7 domain
I6J41_RS33255	COG0456	acetyltransferase
I6J41_RS33270	COG1024	Enoyl-CoA hydratase
I6J41_RS33285	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J41_RS33295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J41_RS33305	COG2340	Cysteine-rich secretory protein family
I6J41_RS33345	COG0488	(ABC) transporter
I6J41_RS33365	COG0009	L-threonylcarbamoyladenylate synthase
I6J41_RS33390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J41_RS33405	COG2318	DinB family
I6J41_RS33415	COG1609	Transcriptional regulator
I6J41_RS33430	COG0395	ABC-type sugar transport system, permease component
I6J41_RS33435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J41_RS33440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS33450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J41_RS33460	COG0714	Associated with various cellular activities
I6J41_RS33465	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J41_RS33495	COG2205	protein histidine kinase activity
I6J41_RS33500	COG0745	RESPONSE REGULATOR receiver
I6J41_RS33515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J41_RS33520	COG1120	ATPase activity
I6J41_RS33535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J41_RS33585	COG0586	Pfam SNARE associated Golgi protein
I6J41_RS33600	COG2226	methyltransferase
I6J41_RS33605	COG0745	RESPONSE REGULATOR receiver
I6J41_RS33610	COG2205	protein histidine kinase activity
I6J41_RS33620	COG1404	Belongs to the peptidase S8 family
I6J41_RS33645	COG1595	DNA-templated transcription, initiation
I6J41_RS33655	COG0831	urea catabolic process
I6J41_RS33660	COG0832	Belongs to the urease beta subunit family
I6J41_RS33670	COG0830	nickel cation binding
I6J41_RS33675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J41_RS33680	COG0829	nickel cation binding
I6J41_RS33690	COG4214	carbohydrate transport
I6J41_RS33700	COG4213	ABC transporter substrate-binding protein
I6J41_RS33710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J41_RS33715	COG0406	alpha-ribazole phosphatase activity
I6J41_RS33725	COG1070	Carbohydrate kinase
I6J41_RS33780	COG0395	ABC-type sugar transport system, permease component
I6J41_RS33805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J41_RS33830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J41_RS33855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J41_RS33875	COG0312	modulator of DNA gyrase
I6J41_RS33900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J41_RS34145	COG3328	transposase activity
I6J41_RS34210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J41_RS34255	COG1192	Involved in chromosome partitioning
I6J41_RS34360	COG4974	Belongs to the 'phage' integrase family
I6J41_RS34450	COG2188	Transcriptional regulator
I6J41_RS34505	COG1518	maintenance of DNA repeat elements
I6J41_RS34510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J41_RS34525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J41_RS34540	COG0302	gtp cyclohydrolase
I6J41_RS34555	COG0720	synthase
I6J41_RS34580	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J41_RS34590	COG4264	IucA IucC family
I6J41_RS34620	COG1051	belongs to the nudix hydrolase family
I6J41_RS34660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J41_RS34665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J41_RS34760	COG0515	serine threonine protein kinase
I6J41_RS34760	COG2815	serine threonine protein kinase
I6J41_RS34785	COG1396	sequence-specific DNA binding
I6J41_RS34820	COG3293	Transposase
I6J41_RS35020	COG3293	Transposase