locus-tag	class	description
I6J42_RS00120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J42_RS00145	COG0312	modulator of DNA gyrase
I6J42_RS00165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J42_RS00190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J42_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS00240	COG0395	ABC-type sugar transport system, permease component
I6J42_RS00295	COG1070	Carbohydrate kinase
I6J42_RS00305	COG0406	alpha-ribazole phosphatase activity
I6J42_RS00310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J42_RS00320	COG4213	ABC transporter substrate-binding protein
I6J42_RS00330	COG4214	carbohydrate transport
I6J42_RS00340	COG0829	nickel cation binding
I6J42_RS00345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J42_RS00350	COG0830	nickel cation binding
I6J42_RS00360	COG0832	Belongs to the urease beta subunit family
I6J42_RS00365	COG0831	urea catabolic process
I6J42_RS00375	COG1595	DNA-templated transcription, initiation
I6J42_RS00400	COG1404	Belongs to the peptidase S8 family
I6J42_RS00410	COG2205	protein histidine kinase activity
I6J42_RS00415	COG0745	RESPONSE REGULATOR receiver
I6J42_RS00420	COG2226	methyltransferase
I6J42_RS00435	COG0586	Pfam SNARE associated Golgi protein
I6J42_RS00485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J42_RS00500	COG1120	ATPase activity
I6J42_RS00505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS00520	COG0745	RESPONSE REGULATOR receiver
I6J42_RS00525	COG2205	protein histidine kinase activity
I6J42_RS00555	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J42_RS00560	COG0714	Associated with various cellular activities
I6J42_RS00570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J42_RS00580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS00585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J42_RS00590	COG0395	ABC-type sugar transport system, permease component
I6J42_RS00605	COG1609	Transcriptional regulator
I6J42_RS00615	COG2318	DinB family
I6J42_RS00630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J42_RS00655	COG0009	L-threonylcarbamoyladenylate synthase
I6J42_RS00675	COG0488	(ABC) transporter
I6J42_RS00715	COG2340	Cysteine-rich secretory protein family
I6J42_RS00725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J42_RS00735	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J42_RS00750	COG1024	Enoyl-CoA hydratase
I6J42_RS00765	COG0456	acetyltransferase
I6J42_RS00775	COG2018	Roadblock/LC7 domain
I6J42_RS00790	COG0640	Transcriptional regulator
I6J42_RS00830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J42_RS00875	COG0385	Bile acid
I6J42_RS00885	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS00905	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS00910	COG0789	Transcriptional regulator
I6J42_RS00930	COG1349	DNA-binding transcription factor activity
I6J42_RS00950	COG1063	alcohol dehydrogenase
I6J42_RS00970	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J42_RS00995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J42_RS01010	COG0477	Major facilitator Superfamily
I6J42_RS01015	COG1278	Cold shock
I6J42_RS01040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J42_RS01100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J42_RS01100	COG1796	DNA polymerase
I6J42_RS01200	COG0444	Belongs to the ABC transporter superfamily
I6J42_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS01210	COG0601	transmembrane transport
I6J42_RS01225	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS01230	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS01260	COG1125	glycine betaine transport
I6J42_RS01260	COG0517	IMP dehydrogenase activity
I6J42_RS01275	COG1174	glycine betaine transport
I6J42_RS01280	COG1174	glycine betaine transport
I6J42_RS01295	COG0297	glycogen (starch) synthase activity
I6J42_RS01295	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS01315	COG0726	polysaccharide deacetylase
I6J42_RS01320	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS01340	COG2304	oxidoreductase activity
I6J42_RS01365	COG1132	(ABC) transporter
I6J42_RS01370	COG1132	(ABC) transporter
I6J42_RS01395	COG1120	ATPase activity
I6J42_RS01400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS01405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS01420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J42_RS01425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J42_RS01430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J42_RS01435	COG0254	rRNA binding
I6J42_RS01445	COG0477	Major facilitator Superfamily
I6J42_RS01510	COG0463	Glycosyl transferase, family 2
I6J42_RS01530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J42_RS01605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J42_RS01620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J42_RS01625	COG1228	amidohydrolase
I6J42_RS01635	COG1834	amidinotransferase
I6J42_RS01640	COG2045	Belongs to the ComB family
I6J42_RS01650	COG1191	sigma factor activity
I6J42_RS01670	COG0714	Associated with various cellular activities
I6J42_RS01690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J42_RS01695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J42_RS01705	COG1609	Transcriptional regulator
I6J42_RS01725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J42_RS01730	COG0121	glutamine amidotransferase
I6J42_RS01735	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J42_RS01750	COG1653	transport
I6J42_RS01755	COG3360	Dodecin
I6J42_RS01765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS01775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J42_RS01780	COG1053	succinate dehydrogenase
I6J42_RS01790	COG0583	DNA-binding transcription factor activity
I6J42_RS01860	COG3275	phosphorelay sensor kinase activity
I6J42_RS01865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J42_RS01880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J42_RS01920	COG1191	sigma factor activity
I6J42_RS01925	COG2201	protein-glutamate methylesterase activity
I6J42_RS01930	COG4251	negative regulation of phosphorylation
I6J42_RS01935	COG0784	Response regulator, receiver
I6J42_RS01945	COG2208	phosphoserine phosphatase activity
I6J42_RS01970	COG1652	LysM domain
I6J42_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS01990	COG0596	Alpha beta hydrolase
I6J42_RS02020	COG1595	DNA-templated transcription, initiation
I6J42_RS02030	COG1119	ATPase activity
I6J42_RS02045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J42_RS02050	COG2837	iron assimilation
I6J42_RS02055	COG0019	diaminopimelate decarboxylase activity
I6J42_RS02065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J42_RS02095	COG1794	racemase activity, acting on amino acids and derivatives
I6J42_RS02110	COG1742	UPF0060 membrane protein
I6J42_RS02115	COG2188	Transcriptional regulator
I6J42_RS02120	COG3647	Membrane
I6J42_RS02140	COG2226	methyltransferase
I6J42_RS02155	COG1175	transmembrane transport
I6J42_RS02160	COG0395	ABC-type sugar transport system, permease component
I6J42_RS02165	COG4948	Mandelate Racemase Muconate Lactonizing
I6J42_RS02175	COG2130	NADP-dependent
I6J42_RS02225	COG1846	Transcriptional regulator
I6J42_RS02230	COG2409	Drug exporters of the RND superfamily
I6J42_RS02240	COG1902	pentaerythritol trinitrate reductase activity
I6J42_RS02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J42_RS02295	COG1280	lysine exporter protein (LysE YggA)
I6J42_RS02320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS02335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J42_RS02370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS02375	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS02380	COG2423	ornithine cyclodeaminase activity
I6J42_RS02385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J42_RS02420	COG2197	response regulator
I6J42_RS02455	COG3851	Histidine kinase
I6J42_RS02460	COG2197	response regulator
I6J42_RS02470	COG3511	phospholipase C
I6J42_RS02485	COG0789	Transcriptional regulator
I6J42_RS02495	COG1733	regulation of RNA biosynthetic process
I6J42_RS02505	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS02515	COG3959	Transketolase, thiamine diphosphate binding domain
I6J42_RS02520	COG3958	Transketolase
I6J42_RS02575	COG0789	Transcriptional regulator
I6J42_RS02585	COG3467	pyridoxamine 5'-phosphate
I6J42_RS02625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J42_RS02635	COG2755	lipolytic protein G-D-S-L family
I6J42_RS02675	COG1657	PFAM Prenyltransferase squalene oxidase
I6J42_RS02685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J42_RS02695	COG1562	ergosterol biosynthetic process
I6J42_RS02700	COG1134	teichoic acid transport
I6J42_RS02720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J42_RS02750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J42_RS02765	COG1024	Enoyl-CoA hydratase
I6J42_RS02775	COG4977	sequence-specific DNA binding
I6J42_RS02795	COG0488	(ABC) transporter
I6J42_RS02810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J42_RS02835	COG0789	Transcriptional regulator
I6J42_RS02840	COG1024	Enoyl-CoA hydratase
I6J42_RS02840	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS02845	COG0183	Belongs to the thiolase family
I6J42_RS02850	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS02855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J42_RS02860	COG3268	Saccharopine dehydrogenase
I6J42_RS02870	COG1515	deoxyribonuclease V activity
I6J42_RS02895	COG0488	(ABC) transporter
I6J42_RS02910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J42_RS02960	COG1793	dna ligase
I6J42_RS02965	COG2326	polyphosphate kinase activity
I6J42_RS03005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J42_RS03030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J42_RS03075	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS03100	COG3012	SEC-C Motif Domain Protein
I6J42_RS03130	COG1486	melibiose metabolic process
I6J42_RS03135	COG2124	cytochrome p450
I6J42_RS03185	COG1940	carbohydrate kinase activity
I6J42_RS03195	COG1070	Carbohydrate kinase
I6J42_RS03205	COG0488	(ABC) transporter
I6J42_RS03245	COG4176	ABC-type proline glycine betaine transport system permease component
I6J42_RS03250	COG4175	Glycine betaine
I6J42_RS03250	COG0517	IMP dehydrogenase activity
I6J42_RS03260	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS03290	COG0745	RESPONSE REGULATOR receiver
I6J42_RS03295	COG5002	protein histidine kinase activity
I6J42_RS03310	COG3568	Endonuclease Exonuclease Phosphatase
I6J42_RS03325	COG0714	Associated with various cellular activities
I6J42_RS03335	COG1869	D-ribose catabolic process
I6J42_RS03340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J42_RS03345	COG1879	ABC-type sugar transport system periplasmic component
I6J42_RS03350	COG1129	ABC transporter
I6J42_RS03360	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS03365	COG0477	Major facilitator Superfamily
I6J42_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS03390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J42_RS03395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J42_RS03400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS03405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS03440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS03460	COG3321	synthase
I6J42_RS03460	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J42_RS03460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS03465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS03470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS03485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J42_RS03490	COG0300	oxidoreductase activity
I6J42_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS03490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS03490	COG3321	synthase
I6J42_RS03490	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS03570	COG0084	hydrolase, TatD family'
I6J42_RS03585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J42_RS03605	COG0673	inositol 2-dehydrogenase activity
I6J42_RS03610	COG1879	ABC-type sugar transport system periplasmic component
I6J42_RS03615	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J42_RS03620	COG1129	ABC transporter
I6J42_RS03630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J42_RS03635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J42_RS03650	COG0656	L-ascorbic acid biosynthetic process
I6J42_RS03680	COG0300	oxidoreductase activity
I6J42_RS03685	COG4106	trans-aconitate 2-methyltransferase activity
I6J42_RS03695	COG0702	epimerase
I6J42_RS03705	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J42_RS03715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J42_RS03715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J42_RS03730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J42_RS03785	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J42_RS03795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J42_RS03800	COG2362	D-Aminopeptidase
I6J42_RS03820	COG0667	Aldo Keto reductase
I6J42_RS03825	COG0583	DNA-binding transcription factor activity
I6J42_RS03855	COG0596	Alpha beta hydrolase
I6J42_RS03865	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS03885	COG0604	alcohol dehydrogenase
I6J42_RS03890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J42_RS03890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J42_RS03895	COG2301	Belongs to the HpcH HpaI aldolase family
I6J42_RS03905	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS03910	COG0688	phosphatidylethanolamine metabolic process
I6J42_RS03945	COG1929	Belongs to the glycerate kinase type-1 family
I6J42_RS03975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J42_RS04000	COG0483	inositol monophosphate 1-phosphatase activity
I6J42_RS04010	COG1024	Enoyl-CoA hydratase
I6J42_RS04015	COG1131	(ABC) transporter
I6J42_RS04025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS04035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J42_RS04040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J42_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS04080	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS04085	COG1024	Enoyl-CoA hydratase
I6J42_RS04130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J42_RS04145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J42_RS04165	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS04170	COG1024	Enoyl-CoA hydratase
I6J42_RS04190	COG0095	Lipoate-protein ligase
I6J42_RS04245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS04260	COG0626	cystathionine gamma-synthase activity
I6J42_RS04305	COG2895	sulfate adenylyltransferase (ATP) activity
I6J42_RS04310	COG0175	sulfate reduction
I6J42_RS04325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS04340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J42_RS04350	COG0463	Glycosyl transferase, family 2
I6J42_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS04460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J42_RS04495	COG0405	Gamma-glutamyltransferase
I6J42_RS04505	COG0183	Belongs to the thiolase family
I6J42_RS04510	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS04510	COG1024	Enoyl-CoA hydratase
I6J42_RS04525	COG0765	amino acid transport
I6J42_RS04530	COG0765	amino acid transport
I6J42_RS04535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS04540	COG1126	abc transporter atp-binding protein
I6J42_RS04575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J42_RS04580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J42_RS04590	COG1940	carbohydrate kinase activity
I6J42_RS04595	COG1129	ABC transporter
I6J42_RS04610	COG2188	Transcriptional regulator
I6J42_RS04615	COG0673	inositol 2-dehydrogenase activity
I6J42_RS04630	COG2197	response regulator
I6J42_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS04655	COG0656	L-ascorbic acid biosynthetic process
I6J42_RS04665	COG4266	Belongs to the allantoicase family
I6J42_RS04670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J42_RS04675	COG1414	Transcriptional regulator
I6J42_RS04695	COG2197	response regulator
I6J42_RS04710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J42_RS04715	COG0242	peptide deformylase activity
I6J42_RS04745	COG1288	antiporter activity
I6J42_RS04770	COG2233	PERMEase
I6J42_RS04780	COG2233	PERMEase
I6J42_RS04790	COG2351	hydroxyisourate hydrolase activity
I6J42_RS04810	COG2706	6-phosphogluconolactonase activity
I6J42_RS04815	COG3622	Belongs to the hyi family
I6J42_RS04820	COG2084	Dehydrogenase
I6J42_RS04825	COG0753	catalase activity
I6J42_RS04850	COG3960	tartronate-semialdehyde synthase activity
I6J42_RS04870	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS04875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J42_RS04880	COG2197	response regulator
I6J42_RS04895	COG0435	Glutathione S-transferase
I6J42_RS04925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS04950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J42_RS04950	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J42_RS04955	COG2252	PERMEase
I6J42_RS04960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J42_RS04985	COG1802	Transcriptional regulator
I6J42_RS05005	COG0028	Belongs to the TPP enzyme family
I6J42_RS05015	COG1404	Belongs to the peptidase S8 family
I6J42_RS05035	COG1162	GTPase activity
I6J42_RS05085	COG0183	Belongs to the thiolase family
I6J42_RS05090	COG0583	DNA-binding transcription factor activity
I6J42_RS05095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J42_RS05100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J42_RS05105	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS05125	COG2814	Major facilitator Superfamily
I6J42_RS05130	COG0583	DNA-binding transcription factor activity
I6J42_RS05155	COG1917	Cupin 2, conserved barrel domain protein
I6J42_RS05170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J42_RS05175	COG3844	kynureninase activity
I6J42_RS05210	COG0175	sulfate reduction
I6J42_RS05215	COG0529	Catalyzes the synthesis of activated sulfate
I6J42_RS05235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J42_RS05240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J42_RS05250	COG2226	methyltransferase
I6J42_RS05255	COG1120	ATPase activity
I6J42_RS05260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS05270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J42_RS05275	COG1132	(ABC) transporter
I6J42_RS05280	COG1132	(ABC) transporter
I6J42_RS05300	COG1404	Belongs to the peptidase S8 family
I6J42_RS05320	COG1175	transmembrane transport
I6J42_RS05375	COG2723	6-phospho-beta-galactosidase activity
I6J42_RS05395	COG1072	(Pantothenic acid kinase))
I6J42_RS05400	COG0346	lactoylglutathione lyase activity
I6J42_RS05410	COG0583	DNA-binding transcription factor activity
I6J42_RS05415	COG0156	8-amino-7-oxononanoate synthase activity
I6J42_RS05420	COG1063	alcohol dehydrogenase
I6J42_RS05525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J42_RS05530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J42_RS05580	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J42_RS05600	COG4152	abc transporter atp-binding protein
I6J42_RS05615	COG3220	belongs to the UPF0276 family
I6J42_RS05630	COG3253	May function as heme-dependent peroxidase
I6J42_RS05635	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J42_RS05645	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J42_RS05650	COG0745	RESPONSE REGULATOR receiver
I6J42_RS05665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J42_RS05690	COG0183	Belongs to the thiolase family
I6J42_RS05695	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS05695	COG1024	Enoyl-CoA hydratase
I6J42_RS05710	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS05735	COG0531	amino acid
I6J42_RS05740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J42_RS05745	COG4214	carbohydrate transport
I6J42_RS05755	COG4213	ABC transporter substrate-binding protein
I6J42_RS05760	COG1940	carbohydrate kinase activity
I6J42_RS05765	COG0395	ABC-type sugar transport system, permease component
I6J42_RS05770	COG1175	transmembrane transport
I6J42_RS05775	COG1653	transport
I6J42_RS05785	COG0588	phosphoglycerate mutase activity
I6J42_RS05805	COG0494	nUDIX hydrolase
I6J42_RS05810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J42_RS05840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J42_RS05855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS05875	COG0475	glutathione-regulated potassium exporter activity
I6J42_RS05900	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS05910	COG0300	oxidoreductase activity
I6J42_RS05925	COG3903	Transcriptional regulator
I6J42_RS05925	COG3629	intracellular signal transduction
I6J42_RS05930	COG0477	Major facilitator Superfamily
I6J42_RS05970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J42_RS05990	COG2197	response regulator
I6J42_RS06005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J42_RS06010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J42_RS06015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J42_RS06050	COG0489	protein tyrosine kinase activity
I6J42_RS06055	COG0297	glycogen (starch) synthase activity
I6J42_RS06070	COG1320	monovalent cation:proton antiporter activity
I6J42_RS06085	COG0651	ATP synthesis coupled electron transport
I6J42_RS06090	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J42_RS06095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J42_RS06095	COG2111	Na H antiporter
I6J42_RS06135	COG1024	Enoyl-CoA hydratase
I6J42_RS06145	COG0531	amino acid
I6J42_RS06150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J42_RS06160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J42_RS06170	COG2040	homocysteine
I6J42_RS06190	COG1799	cell septum assembly
I6J42_RS06195	COG1349	DNA-binding transcription factor activity
I6J42_RS06200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J42_RS06205	COG0586	Pfam SNARE associated Golgi protein
I6J42_RS06215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS06220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS06250	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J42_RS06255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J42_RS06260	COG1280	lysine exporter protein (LysE YggA)
I6J42_RS06270	COG3291	Pkd domain containing protein
I6J42_RS06285	COG0601	transmembrane transport
I6J42_RS06290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS06300	COG0006	proline dipeptidase activity
I6J42_RS06305	COG1802	Transcriptional regulator
I6J42_RS06310	COG2423	ornithine cyclodeaminase activity
I6J42_RS06320	COG3938	Belongs to the proline racemase family
I6J42_RS06330	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J42_RS06340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J42_RS06350	COG0596	Alpha beta hydrolase
I6J42_RS06365	COG2814	Major facilitator Superfamily
I6J42_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS06410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J42_RS06430	COG4552	Acetyltransferase involved in intracellular survival and related
I6J42_RS06435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J42_RS06465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J42_RS06470	COG0531	amino acid
I6J42_RS06475	COG0569	domain protein
I6J42_RS06500	COG1136	(ABC) transporter
I6J42_RS06500	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J42_RS06510	COG0756	dUTP diphosphatase activity
I6J42_RS06535	COG2205	protein histidine kinase activity
I6J42_RS06540	COG0745	RESPONSE REGULATOR receiver
I6J42_RS06555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J42_RS06595	COG1435	thymidine kinase activity
I6J42_RS06610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J42_RS06610	COG1042	CoA-binding domain protein
I6J42_RS06610	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J42_RS06615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J42_RS06620	COG1802	Transcriptional regulator
I6J42_RS06635	COG0612	Peptidase, M16
I6J42_RS06640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J42_RS06650	COG0372	Belongs to the citrate synthase family
I6J42_RS06655	COG0372	Belongs to the citrate synthase family
I6J42_RS06660	COG3290	protein histidine kinase activity
I6J42_RS06665	COG4565	transcriptional regulatory protein
I6J42_RS06670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J42_RS06695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J42_RS06700	COG2186	Transcriptional regulator
I6J42_RS06735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J42_RS06765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J42_RS06770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J42_RS06775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J42_RS06815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J42_RS06825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J42_RS06830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J42_RS06840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J42_RS06855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J42_RS06860	COG2358	TRAP transporter, solute receptor (TAXI family
I6J42_RS06865	COG2205	protein histidine kinase activity
I6J42_RS06875	COG1126	abc transporter atp-binding protein
I6J42_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS06885	COG0765	amino acid transport
I6J42_RS06890	COG0765	amino acid transport
I6J42_RS06920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J42_RS06950	COG1917	Cupin 2, conserved barrel domain protein
I6J42_RS06950	COG2207	Transcriptional regulator
I6J42_RS06955	COG1201	RNA secondary structure unwinding
I6J42_RS06960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J42_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS06975	COG0783	Belongs to the Dps family
I6J42_RS06980	COG1396	sequence-specific DNA binding
I6J42_RS06985	COG1546	Belongs to the CinA family
I6J42_RS06985	COG1058	Belongs to the CinA family
I6J42_RS06995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J42_RS07005	COG1674	ftsk spoiiie
I6J42_RS07015	COG2205	protein histidine kinase activity
I6J42_RS07015	COG4999	Histidine kinase
I6J42_RS07015	COG3437	response regulator, receiver
I6J42_RS07015	COG3850	Histidine kinase
I6J42_RS07045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J42_RS07050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J42_RS07055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J42_RS07075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J42_RS07080	COG0612	Peptidase, M16
I6J42_RS07085	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J42_RS07090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J42_RS07100	COG1674	ftsk spoiiie
I6J42_RS07115	COG1404	Belongs to the peptidase S8 family
I6J42_RS07130	COG1404	Belongs to the peptidase S8 family
I6J42_RS07155	COG0455	bacterial-type flagellum organization
I6J42_RS07160	COG0747	negative chemotaxis
I6J42_RS07165	COG0601	transmembrane transport
I6J42_RS07170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS07180	COG4608	Belongs to the ABC transporter superfamily
I6J42_RS07215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J42_RS07220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J42_RS07230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J42_RS07245	COG0779	Required for maturation of 30S ribosomal subunits
I6J42_RS07265	COG0442	prolyl-tRNA aminoacylation
I6J42_RS07280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J42_RS07285	COG0750	zinc metalloprotease
I6J42_RS07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J42_RS07295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J42_RS07305	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS07310	COG2814	Major facilitator Superfamily
I6J42_RS07320	COG2508	Transcriptional regulator
I6J42_RS07350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J42_RS07355	COG1177	transmembrane transport
I6J42_RS07360	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J42_RS07365	COG3842	ATPase activity
I6J42_RS07395	COG1595	DNA-templated transcription, initiation
I6J42_RS07435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J42_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS07470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J42_RS07485	COG3842	ATPase activity
I6J42_RS07500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J42_RS07505	COG2226	methyltransferase
I6J42_RS07590	COG0575	Belongs to the CDS family
I6J42_RS07595	COG0233	cytoplasmic translational termination
I6J42_RS07600	COG0528	UMP kinase activity
I6J42_RS07605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J42_RS07610	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J42_RS07625	COG1191	sigma factor activity
I6J42_RS07690	COG0792	nuclease activity
I6J42_RS07700	COG1051	belongs to the nudix hydrolase family
I6J42_RS07710	COG0681	Belongs to the peptidase S26 family
I6J42_RS07725	COG0335	large ribosomal subunit rRNA binding
I6J42_RS07730	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J42_RS07735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J42_RS07740	COG1837	Belongs to the UPF0109 family
I6J42_RS07745	COG0228	four-way junction DNA binding
I6J42_RS07765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J42_RS07800	COG0477	Major facilitator Superfamily
I6J42_RS07805	COG1196	nuclear chromosome segregation
I6J42_RS07815	COG1254	Belongs to the acylphosphatase family
I6J42_RS07820	COG2340	Cysteine-rich secretory protein family
I6J42_RS07855	COG0546	phosphoglycolate phosphatase activity
I6J42_RS07865	COG1733	regulation of RNA biosynthetic process
I6J42_RS07870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J42_RS07875	COG0571	ribonuclease III activity
I6J42_RS07880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J42_RS07895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J42_RS07900	COG0742	ribosomal rna small subunit methyltransferase
I6J42_RS07910	COG1461	Dihydroxyacetone kinase
I6J42_RS07915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J42_RS07920	COG0351	phosphomethylpyrimidine kinase
I6J42_RS07940	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J42_RS07945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J42_RS07955	COG1920	GTP binding
I6J42_RS07965	COG0776	regulation of translation
I6J42_RS07975	COG0066	3-isopropylmalate dehydratase activity
I6J42_RS07980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J42_RS07985	COG1414	Transcriptional regulator
I6J42_RS08030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J42_RS08035	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J42_RS08045	COG5002	protein histidine kinase activity
I6J42_RS08050	COG2018	Roadblock/LC7 domain
I6J42_RS08070	COG2018	Roadblock/LC7 domain
I6J42_RS08090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J42_RS08095	COG0366	Alpha amylase catalytic
I6J42_RS08095	COG1470	cell adhesion involved in biofilm formation
I6J42_RS08110	COG2353	YceI-like domain
I6J42_RS08115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J42_RS08120	COG1120	ATPase activity
I6J42_RS08125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS08130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS08175	COG0492	ferredoxin-NADP+ reductase activity
I6J42_RS08195	COG3708	Transcriptional regulator
I6J42_RS08195	COG2207	Transcriptional regulator
I6J42_RS08210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J42_RS08235	COG0542	response to heat
I6J42_RS08245	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J42_RS08250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J42_RS08260	COG2957	Belongs to the agmatine deiminase family
I6J42_RS08270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J42_RS08275	COG0473	3-isopropylmalate dehydrogenase activity
I6J42_RS08290	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J42_RS08290	COG0778	Nitroreductase
I6J42_RS08295	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS08300	COG0506	proline dehydrogenase activity
I6J42_RS08305	COG2508	Transcriptional regulator
I6J42_RS08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J42_RS08335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J42_RS08340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J42_RS08345	COG0440	acetolactate synthase activity
I6J42_RS08355	COG3300	MHYT domain
I6J42_RS08355	COG5001	Diguanylate cyclase
I6J42_RS08365	COG0667	Aldo Keto reductase
I6J42_RS08370	COG2133	pyrroloquinoline quinone binding
I6J42_RS08380	COG2197	response regulator
I6J42_RS08395	COG2409	Drug exporters of the RND superfamily
I6J42_RS08405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J42_RS08410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J42_RS08420	COG0154	amidase activity
I6J42_RS08425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J42_RS08435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J42_RS08445	COG4221	oxidoreductase activity
I6J42_RS08465	COG0482	sulfurtransferase activity
I6J42_RS08495	COG2378	regulation of single-species biofilm formation
I6J42_RS08505	COG2860	membrane
I6J42_RS08510	COG4608	Belongs to the ABC transporter superfamily
I6J42_RS08520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS08525	COG0601	transmembrane transport
I6J42_RS08530	COG0747	negative chemotaxis
I6J42_RS08550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J42_RS08555	COG0509	glycine decarboxylation via glycine cleavage system
I6J42_RS08560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J42_RS08565	COG1760	l-serine dehydratase
I6J42_RS08595	COG0464	growth
I6J42_RS08605	COG1506	peptidase
I6J42_RS08605	COG0823	Involved in the tonB-independent uptake of proteins
I6J42_RS08705	COG0515	serine threonine protein kinase
I6J42_RS08755	COG2197	response regulator
I6J42_RS08770	COG1131	(ABC) transporter
I6J42_RS08780	COG1132	(ABC) transporter
I6J42_RS08785	COG1742	UPF0060 membrane protein
I6J42_RS08805	COG0387	Pfam Sodium calcium exchanger
I6J42_RS08825	COG0058	SHG alpha-glucan phosphorylase activity
I6J42_RS08830	COG0366	Alpha amylase catalytic
I6J42_RS08835	COG0366	Alpha amylase catalytic
I6J42_RS08845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J42_RS08870	COG1301	dicarboxylic acid transport
I6J42_RS08875	COG3290	protein histidine kinase activity
I6J42_RS08880	COG4565	transcriptional regulatory protein
I6J42_RS08890	COG0205	6-phosphofructokinase activity
I6J42_RS08895	COG0280	phosphate acetyltransferase
I6J42_RS08895	COG0857	belongs to the CobB CobQ family
I6J42_RS08900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J42_RS08945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J42_RS08945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J42_RS09015	COG5002	protein histidine kinase activity
I6J42_RS09015	COG5000	phosphorelay sensor kinase activity
I6J42_RS09020	COG0745	RESPONSE REGULATOR receiver
I6J42_RS09035	COG0183	Belongs to the thiolase family
I6J42_RS09090	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J42_RS09105	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS09135	COG4585	Histidine kinase
I6J42_RS09140	COG2197	response regulator
I6J42_RS09155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J42_RS09160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J42_RS09165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J42_RS09170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J42_RS09175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J42_RS09180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J42_RS09185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J42_RS09205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J42_RS09210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J42_RS09220	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J42_RS09225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J42_RS09230	COG0254	rRNA binding
I6J42_RS09235	COG1316	TRANSCRIPTIONal
I6J42_RS09245	COG0083	homoserine kinase activity
I6J42_RS09250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J42_RS09255	COG0460	homoserine dehydrogenase
I6J42_RS09260	COG0019	diaminopimelate decarboxylase activity
I6J42_RS09265	COG0018	arginyl-trna synthetase
I6J42_RS09290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J42_RS09300	COG0515	serine threonine protein kinase
I6J42_RS09305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J42_RS09310	COG1793	dna ligase
I6J42_RS09310	COG3285	dna ligase
I6J42_RS09330	COG2205	protein histidine kinase activity
I6J42_RS09380	COG1309	transcriptional regulator
I6J42_RS09440	COG0726	polysaccharide deacetylase
I6J42_RS09445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J42_RS09455	COG0745	RESPONSE REGULATOR receiver
I6J42_RS09460	COG2205	protein histidine kinase activity
I6J42_RS09465	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J42_RS09465	COG0567	Dehydrogenase, E1 component
I6J42_RS09490	COG0542	response to heat
I6J42_RS09510	COG0604	alcohol dehydrogenase
I6J42_RS09515	COG0281	malic enzyme
I6J42_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS09525	COG0765	amino acid transport
I6J42_RS09530	COG1126	abc transporter atp-binding protein
I6J42_RS09540	COG1595	DNA-templated transcription, initiation
I6J42_RS09545	COG4106	trans-aconitate 2-methyltransferase activity
I6J42_RS09570	COG0242	peptide deformylase activity
I6J42_RS09605	COG1695	Transcriptional regulator
I6J42_RS09625	COG4585	Histidine kinase
I6J42_RS09630	COG2197	response regulator
I6J42_RS09695	COG0142	geranyltranstransferase activity
I6J42_RS09700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J42_RS09705	COG1959	2 iron, 2 sulfur cluster binding
I6J42_RS09745	COG1597	lipid kinase activity
I6J42_RS09760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J42_RS09765	COG0363	glucosamine-6-phosphate deaminase activity
I6J42_RS09770	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J42_RS09775	COG0395	ABC-type sugar transport system, permease component
I6J42_RS09780	COG1175	transmembrane transport
I6J42_RS09785	COG2182	Extracellular solute-binding protein
I6J42_RS09790	COG2188	Transcriptional regulator
I6J42_RS09795	COG1966	Carbon starvation protein
I6J42_RS09830	COG0242	peptide deformylase activity
I6J42_RS09840	COG5662	AntiSigma factor
I6J42_RS09845	COG1595	DNA-templated transcription, initiation
I6J42_RS09855	COG2135	peptidase activity
I6J42_RS09865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J42_RS09875	COG2076	Multidrug Resistance protein
I6J42_RS09885	COG0483	inositol monophosphate 1-phosphatase activity
I6J42_RS09895	COG0753	catalase activity
I6J42_RS09920	COG1615	UPF0182 protein
I6J42_RS09930	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J42_RS10030	COG0210	DNA helicase
I6J42_RS10075	COG4172	Belongs to the ABC transporter superfamily
I6J42_RS10080	COG0601	transmembrane transport
I6J42_RS10090	COG0747	negative chemotaxis
I6J42_RS10130	COG0513	Belongs to the DEAD box helicase family
I6J42_RS10140	COG1432	Conserved Protein
I6J42_RS10150	COG2095	MarC family integral membrane protein
I6J42_RS10165	COG2814	Major facilitator Superfamily
I6J42_RS10175	COG0598	Magnesium transport protein CorA
I6J42_RS10210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J42_RS10215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J42_RS10225	COG1595	DNA-templated transcription, initiation
I6J42_RS10240	COG1024	Enoyl-CoA hydratase
I6J42_RS10245	COG0519	Catalyzes the synthesis of GMP from XMP
I6J42_RS10255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J42_RS10260	COG1611	Belongs to the LOG family
I6J42_RS10265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J42_RS10295	COG2912	Transglutaminase-like superfamily
I6J42_RS10300	COG2197	response regulator
I6J42_RS10305	COG1132	(ABC) transporter
I6J42_RS10320	COG0515	serine threonine protein kinase
I6J42_RS10335	COG0110	maltose O-acetyltransferase activity
I6J42_RS10355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J42_RS10370	COG4608	Belongs to the ABC transporter superfamily
I6J42_RS10380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS10385	COG0601	transmembrane transport
I6J42_RS10390	COG4166	transmembrane transport
I6J42_RS10395	COG4608	Belongs to the ABC transporter superfamily
I6J42_RS10405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS10410	COG0601	transmembrane transport
I6J42_RS10420	COG1217	gtp-binding protein TYPA
I6J42_RS10435	COG0154	amidase activity
I6J42_RS10440	COG2197	response regulator
I6J42_RS10445	COG4585	Histidine kinase
I6J42_RS10450	COG2409	Drug exporters of the RND superfamily
I6J42_RS10465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J42_RS10520	COG0789	Transcriptional regulator
I6J42_RS10650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J42_RS10660	COG0477	Major facilitator Superfamily
I6J42_RS10670	COG0012	GTP binding
I6J42_RS10685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J42_RS10695	COG1570	exodeoxyribonuclease VII activity
I6J42_RS10700	COG1722	exodeoxyribonuclease VII activity
I6J42_RS10705	COG0778	Nitroreductase
I6J42_RS10730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J42_RS10730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J42_RS10760	COG1362	aminopeptidase activity
I6J42_RS10770	COG0114	fumarate hydratase activity
I6J42_RS10785	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J42_RS10785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J42_RS10805	COG1136	(ABC) transporter
I6J42_RS10820	COG0450	alkyl hydroperoxide reductase
I6J42_RS10825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J42_RS10840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J42_RS10845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J42_RS10850	COG0667	Aldo Keto reductase
I6J42_RS10860	COG2226	methyltransferase
I6J42_RS10925	COG2885	chlorophyll binding
I6J42_RS10945	COG2197	response regulator
I6J42_RS10980	COG2894	cell division
I6J42_RS11005	COG2610	gluconate transmembrane transporter activity
I6J42_RS11010	COG0251	oxidation-reduction process
I6J42_RS11015	COG1414	Transcriptional regulator
I6J42_RS11030	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J42_RS11050	COG1733	regulation of RNA biosynthetic process
I6J42_RS11070	COG0436	Aminotransferase
I6J42_RS11080	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J42_RS11090	COG1331	Highly conserved protein containing a thioredoxin domain
I6J42_RS11115	COG0154	amidase activity
I6J42_RS11145	COG4585	Histidine kinase
I6J42_RS11155	COG0577	efflux transmembrane transporter activity
I6J42_RS11155	COG1136	(ABC) transporter
I6J42_RS11160	COG2197	response regulator
I6J42_RS11165	COG2175	clavaminate synthase activity
I6J42_RS11170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J42_RS11200	COG3251	PFAM MbtH domain protein
I6J42_RS11205	COG0300	oxidoreductase activity
I6J42_RS11205	COG3321	synthase
I6J42_RS11205	COG3321	synthase
I6J42_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS11205	COG0300	oxidoreductase activity
I6J42_RS11205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS11205	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS11205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS11205	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS11225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J42_RS11250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J42_RS11260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J42_RS11275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J42_RS11285	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS11290	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS11295	COG2172	sigma factor antagonist activity
I6J42_RS11305	COG0784	Response regulator, receiver
I6J42_RS11305	COG2198	Histidine kinase
I6J42_RS11305	COG5002	protein histidine kinase activity
I6J42_RS11310	COG0745	RESPONSE REGULATOR receiver
I6J42_RS11315	COG1595	DNA-templated transcription, initiation
I6J42_RS11340	COG0501	Belongs to the peptidase M48B family
I6J42_RS11355	COG0583	DNA-binding transcription factor activity
I6J42_RS11360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J42_RS11370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J42_RS11390	COG1376	ErfK ybiS ycfS ynhG family protein
I6J42_RS11415	COG1024	Enoyl-CoA hydratase
I6J42_RS11430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J42_RS11440	COG0424	maF-like protein
I6J42_RS11450	COG4770	biotin carboxylase activity
I6J42_RS11480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J42_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS11515	COG1595	DNA-templated transcription, initiation
I6J42_RS11520	COG0745	RESPONSE REGULATOR receiver
I6J42_RS11525	COG2205	protein histidine kinase activity
I6J42_RS11550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J42_RS11570	COG0583	DNA-binding transcription factor activity
I6J42_RS11575	COG2814	Major facilitator Superfamily
I6J42_RS11595	COG1404	Belongs to the peptidase S8 family
I6J42_RS11615	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J42_RS11620	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J42_RS11625	COG3845	ABC transporter
I6J42_RS11630	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J42_RS11635	COG1473	amidohydrolase
I6J42_RS11635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J42_RS11660	COG2089	acid synthase
I6J42_RS11665	COG1083	cytidylyl-transferase
I6J42_RS11675	COG1216	Glycosyl transferase, family 2
I6J42_RS11720	COG1595	DNA-templated transcription, initiation
I6J42_RS11725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J42_RS11765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J42_RS11770	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J42_RS11775	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J42_RS11825	COG2009	succinate dehydrogenase
I6J42_RS11835	COG1053	succinate dehydrogenase
I6J42_RS11840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J42_RS11875	COG1408	metallophosphoesterase
I6J42_RS11890	COG1295	ribonuclease BN
I6J42_RS11910	COG0180	Tryptophanyl-tRNA synthetase
I6J42_RS11915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J42_RS11920	COG0754	glutathionylspermidine amidase activity
I6J42_RS11930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J42_RS11935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J42_RS11955	COG0039	L-malate dehydrogenase activity
I6J42_RS11970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J42_RS11985	COG0138	bifunctional purine biosynthesis protein purh
I6J42_RS12015	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J42_RS12020	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J42_RS12030	COG0714	Associated with various cellular activities
I6J42_RS12050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J42_RS12060	COG0739	heme binding
I6J42_RS12085	COG2197	response regulator
I6J42_RS12115	COG4106	trans-aconitate 2-methyltransferase activity
I6J42_RS12125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J42_RS12125	COG0519	Catalyzes the synthesis of GMP from XMP
I6J42_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS12150	COG0515	serine threonine protein kinase
I6J42_RS12165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J42_RS12180	COG0516	GMP reductase activity
I6J42_RS12190	COG1595	DNA-templated transcription, initiation
I6J42_RS12205	COG0583	DNA-binding transcription factor activity
I6J42_RS12220	COG2132	Multicopper oxidase
I6J42_RS12235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J42_RS12245	COG0726	polysaccharide deacetylase
I6J42_RS12280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J42_RS12305	COG0802	atpase or kinase
I6J42_RS12320	COG3189	MarR family transcriptional regulator
I6J42_RS12330	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J42_RS12335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J42_RS12415	COG1072	(Pantothenic acid kinase))
I6J42_RS12425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J42_RS12430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J42_RS12435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J42_RS12440	COG0488	(ABC) transporter
I6J42_RS12450	COG0101	tRNA pseudouridine synthase activity
I6J42_RS12455	COG0203	ribosomal protein L17
I6J42_RS12460	COG0202	RNA polymerase activity
I6J42_RS12465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J42_RS12470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J42_RS12475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J42_RS12480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J42_RS12490	COG0563	adenylate kinase activity
I6J42_RS12500	COG0200	Binds to the 23S rRNA
I6J42_RS12505	COG1841	ribosomal large subunit assembly
I6J42_RS12510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J42_RS12515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J42_RS12520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J42_RS12525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J42_RS12530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J42_RS12535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J42_RS12540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J42_RS12545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J42_RS12550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J42_RS12555	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J42_RS12560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J42_RS12565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J42_RS12570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J42_RS12575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J42_RS12580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J42_RS12585	COG0089	rRNA binding
I6J42_RS12590	COG0088	Forms part of the polypeptide exit tunnel
I6J42_RS12595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J42_RS12600	COG0051	transcription antitermination factor activity, RNA binding
I6J42_RS12615	COG2197	response regulator
I6J42_RS12620	COG4585	Histidine kinase
I6J42_RS12625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J42_RS12630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J42_RS12635	COG0049	tRNA binding
I6J42_RS12640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J42_RS12655	COG0741	lytic transglycosylase activity
I6J42_RS12655	COG0739	heme binding
I6J42_RS12655	COG1196	nuclear chromosome segregation
I6J42_RS12735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J42_RS12740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J42_RS12745	COG0085	RNA polymerase activity
I6J42_RS12750	COG0222	ribosome binding
I6J42_RS12755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J42_RS12765	COG0081	regulation of translation
I6J42_RS12770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J42_RS12790	COG0436	Aminotransferase
I6J42_RS12795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J42_RS12800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J42_RS12820	COG2030	dehydratase
I6J42_RS12825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J42_RS12845	COG0702	epimerase
I6J42_RS12855	COG1666	GTP binding
I6J42_RS12860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J42_RS12875	COG3304	Inner membrane component domain
I6J42_RS12880	COG0501	Belongs to the peptidase M48B family
I6J42_RS12885	COG1970	mechanosensitive ion channel activity
I6J42_RS12890	COG1007	ATP synthesis coupled electron transport
I6J42_RS12900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J42_RS12905	COG0713	ATP synthesis coupled electron transport
I6J42_RS12910	COG0839	Belongs to the complex I subunit 6 family
I6J42_RS12915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS12920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J42_RS12925	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS12935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS12950	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J42_RS12950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J42_RS12955	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J42_RS12960	COG1733	regulation of RNA biosynthetic process
I6J42_RS12965	COG0702	epimerase
I6J42_RS13055	COG0667	Aldo Keto reductase
I6J42_RS13070	COG0561	phosphatase activity
I6J42_RS13090	COG4221	oxidoreductase activity
I6J42_RS13095	COG0789	Transcriptional regulator
I6J42_RS13110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J42_RS13110	COG0515	serine threonine protein kinase
I6J42_RS13135	COG0142	geranyltranstransferase activity
I6J42_RS13140	COG3104	oligopeptide transport
I6J42_RS13175	COG0514	ATP-dependent DNA helicase (RecQ)
I6J42_RS13180	COG1007	ATP synthesis coupled electron transport
I6J42_RS13190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J42_RS13195	COG0713	ATP synthesis coupled electron transport
I6J42_RS13200	COG0839	Belongs to the complex I subunit 6 family
I6J42_RS13205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS13210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J42_RS13215	COG1034	ATP synthesis coupled electron transport
I6J42_RS13220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J42_RS13230	COG0649	NAD binding
I6J42_RS13235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS13240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J42_RS13305	COG2226	methyltransferase
I6J42_RS13310	COG2175	clavaminate synthase activity
I6J42_RS13320	COG4521	taurine ABC transporter
I6J42_RS13325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J42_RS13350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J42_RS13360	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J42_RS13365	COG1278	Cold shock
I6J42_RS13370	COG0789	Transcriptional regulator
I6J42_RS13400	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS13415	COG1024	Enoyl-CoA hydratase
I6J42_RS13440	COG1309	transcriptional regulator
I6J42_RS13450	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS13475	COG0501	Belongs to the peptidase M48B family
I6J42_RS13490	COG2124	cytochrome p450
I6J42_RS13505	COG2072	flavoprotein involved in K transport
I6J42_RS13515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J42_RS13540	COG1024	Enoyl-CoA hydratase
I6J42_RS13545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J42_RS13585	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS13605	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS13610	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS13620	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS13630	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS13660	COG0604	alcohol dehydrogenase
I6J42_RS13715	COG4821	SIS domain
I6J42_RS13725	COG0259	pyridoxamine-phosphate oxidase activity
I6J42_RS13745	COG1396	sequence-specific DNA binding
I6J42_RS13815	COG1024	Enoyl-CoA hydratase
I6J42_RS13820	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS13835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J42_RS13860	COG1309	transcriptional regulator
I6J42_RS13865	COG4221	oxidoreductase activity
I6J42_RS13870	COG5006	permease, DMT superfamily
I6J42_RS13875	COG0583	DNA-binding transcription factor activity
I6J42_RS13880	COG0247	lactate metabolic process
I6J42_RS13880	COG0277	FAD linked oxidase domain protein
I6J42_RS13885	COG2205	protein histidine kinase activity
I6J42_RS13915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J42_RS13925	COG2318	DinB family
I6J42_RS13940	COG1335	isochorismatase
I6J42_RS14000	COG1309	transcriptional regulator
I6J42_RS14020	COG2205	protein histidine kinase activity
I6J42_RS14025	COG0745	RESPONSE REGULATOR receiver
I6J42_RS14045	COG0577	efflux transmembrane transporter activity
I6J42_RS14045	COG1136	(ABC) transporter
I6J42_RS14085	COG2161	toxin-antitoxin pair type II binding
I6J42_RS14110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J42_RS14145	COG2318	DinB family
I6J42_RS14180	COG0113	porphobilinogen synthase activity
I6J42_RS14185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J42_RS14185	COG1648	precorrin-2 dehydrogenase activity
I6J42_RS14190	COG0181	hydroxymethylbilane synthase activity
I6J42_RS14195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J42_RS14200	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J42_RS14260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS14280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J42_RS14290	COG1129	ABC transporter
I6J42_RS14290	COG0842	Transport permease protein
I6J42_RS14300	COG4991	sh3 domain protein
I6J42_RS14305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J42_RS14305	COG0515	serine threonine protein kinase
I6J42_RS14310	COG0129	dihydroxy-acid dehydratase activity
I6J42_RS14320	COG1082	Xylose isomerase domain protein TIM barrel
I6J42_RS14325	COG0248	Ppx GppA phosphatase
I6J42_RS14345	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6J42_RS14355	COG1194	a g-specific adenine glycosylase
I6J42_RS14360	COG1595	DNA-templated transcription, initiation
I6J42_RS14370	COG0745	RESPONSE REGULATOR receiver
I6J42_RS14375	COG2205	protein histidine kinase activity
I6J42_RS14380	COG0739	heme binding
I6J42_RS14410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J42_RS14430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J42_RS14440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J42_RS14445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J42_RS14470	COG1660	Displays ATPase and GTPase activities
I6J42_RS14475	COG2197	response regulator
I6J42_RS14490	COG0649	NAD binding
I6J42_RS14505	COG1174	glycine betaine transport
I6J42_RS14510	COG1174	glycine betaine transport
I6J42_RS14515	COG1125	glycine betaine transport
I6J42_RS14515	COG0517	IMP dehydrogenase activity
I6J42_RS14525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J42_RS14525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J42_RS14540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J42_RS14555	COG0302	gtp cyclohydrolase
I6J42_RS14570	COG0037	tRNA processing
I6J42_RS14580	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J42_RS14585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J42_RS14595	COG0586	Pfam SNARE associated Golgi protein
I6J42_RS14600	COG0393	Putative heavy-metal-binding
I6J42_RS14610	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J42_RS14615	COG0076	glutamate decarboxylase activity
I6J42_RS14645	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS14705	COG1653	transport
I6J42_RS14715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J42_RS14740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J42_RS14775	COG2197	response regulator
I6J42_RS14795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J42_RS14815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J42_RS14860	COG0745	RESPONSE REGULATOR receiver
I6J42_RS14920	COG3842	ATPase activity
I6J42_RS14945	COG0215	cysteine-tRNA ligase activity
I6J42_RS14950	COG3467	pyridoxamine 5'-phosphate
I6J42_RS14960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J42_RS14975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J42_RS14980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J42_RS14985	COG1329	Transcriptional regulator
I6J42_RS15000	COG5002	protein histidine kinase activity
I6J42_RS15020	COG0588	phosphoglycerate mutase activity
I6J42_RS15030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J42_RS15035	COG0798	PFAM Bile acid sodium symporter
I6J42_RS15040	COG0640	Transcriptional regulator
I6J42_RS15095	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS15160	COG4942	peptidase
I6J42_RS15200	COG4552	Acetyltransferase involved in intracellular survival and related
I6J42_RS15215	COG1490	D-aminoacyl-tRNA deacylase activity
I6J42_RS15225	COG0735	belongs to the Fur family
I6J42_RS15230	COG3485	protocatechuate 3,4-dioxygenase
I6J42_RS15250	COG2897	thiosulfate sulfurtransferase activity
I6J42_RS15275	COG0745	RESPONSE REGULATOR receiver
I6J42_RS15280	COG1609	Transcriptional regulator
I6J42_RS15285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J42_RS15320	COG0739	heme binding
I6J42_RS15335	COG4977	sequence-specific DNA binding
I6J42_RS15350	COG0154	amidase activity
I6J42_RS15375	COG4106	trans-aconitate 2-methyltransferase activity
I6J42_RS15380	COG0737	Belongs to the 5'-nucleotidase family
I6J42_RS15390	COG0456	acetyltransferase
I6J42_RS15400	COG1725	Transcriptional regulator
I6J42_RS15420	COG0494	nUDIX hydrolase
I6J42_RS15420	COG0406	alpha-ribazole phosphatase activity
I6J42_RS15425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J42_RS15445	COG0306	phosphate transporter
I6J42_RS15455	COG1937	Protein conserved in bacteria
I6J42_RS15475	COG0671	phosphoesterase, PA-phosphatase related
I6J42_RS15480	COG1196	nuclear chromosome segregation
I6J42_RS15480	COG0741	lytic transglycosylase activity
I6J42_RS15480	COG0739	heme binding
I6J42_RS15560	COG4585	Histidine kinase
I6J42_RS15565	COG2197	response regulator
I6J42_RS15585	COG1846	Transcriptional regulator
I6J42_RS15600	COG1252	NADH dehydrogenase
I6J42_RS15625	COG0579	oxidoreductase
I6J42_RS15630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J42_RS15645	COG1196	nuclear chromosome segregation
I6J42_RS15645	COG0741	lytic transglycosylase activity
I6J42_RS15645	COG0739	heme binding
I6J42_RS15665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J42_RS15670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J42_RS15675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J42_RS15675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J42_RS15690	COG1937	Protein conserved in bacteria
I6J42_RS15705	COG1191	sigma factor activity
I6J42_RS15715	COG0596	Alpha beta hydrolase
I6J42_RS15725	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS15730	COG0596	Alpha beta hydrolase
I6J42_RS15740	COG0513	Belongs to the DEAD box helicase family
I6J42_RS15750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J42_RS15785	COG0785	Cytochrome C biogenesis protein
I6J42_RS15790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J42_RS15790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J42_RS15800	COG1643	Atp-dependent helicase
I6J42_RS15820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J42_RS15830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J42_RS15840	COG3119	arylsulfatase activity
I6J42_RS15855	COG0739	heme binding
I6J42_RS15855	COG1196	nuclear chromosome segregation
I6J42_RS15855	COG0741	lytic transglycosylase activity
I6J42_RS15865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J42_RS15870	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J42_RS15875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J42_RS15895	COG1131	(ABC) transporter
I6J42_RS15910	COG2197	response regulator
I6J42_RS15920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J42_RS15935	COG0151	Belongs to the GarS family
I6J42_RS15960	COG0492	ferredoxin-NADP+ reductase activity
I6J42_RS16080	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J42_RS16130	COG4941	Belongs to the sigma-70 factor family
I6J42_RS16210	COG0464	growth
I6J42_RS16245	COG2234	aminopeptidase activity
I6J42_RS16260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J42_RS16300	COG1191	sigma factor activity
I6J42_RS16305	COG1191	sigma factor activity
I6J42_RS16330	COG2353	YceI-like domain
I6J42_RS16335	COG3467	pyridoxamine 5'-phosphate
I6J42_RS16350	COG0477	Major facilitator Superfamily
I6J42_RS16360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J42_RS16375	COG0745	RESPONSE REGULATOR receiver
I6J42_RS16395	COG1595	DNA-templated transcription, initiation
I6J42_RS16400	COG1252	NADH dehydrogenase
I6J42_RS16410	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J42_RS16430	COG0494	nUDIX hydrolase
I6J42_RS16450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J42_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS16490	COG1595	DNA-templated transcription, initiation
I6J42_RS16515	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS16540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J42_RS16555	COG0653	protein targeting
I6J42_RS16570	COG0006	proline dipeptidase activity
I6J42_RS16590	COG1999	signal sequence binding
I6J42_RS16600	COG2372	response to copper ion
I6J42_RS16605	COG2837	iron assimilation
I6J42_RS16615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J42_RS16620	COG0561	phosphatase activity
I6J42_RS16645	COG1131	(ABC) transporter
I6J42_RS16660	COG0789	Transcriptional regulator
I6J42_RS16665	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J42_RS16675	COG0561	phosphatase activity
I6J42_RS16685	COG4988	ABC transporter
I6J42_RS16690	COG1294	oxidase, subunit
I6J42_RS16695	COG1271	oxidase subunit
I6J42_RS16700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J42_RS16705	COG1609	Transcriptional regulator
I6J42_RS16710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J42_RS16720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J42_RS16745	COG0662	Cupin 2, conserved barrel domain protein
I6J42_RS16750	COG1950	PFAM Membrane protein of
I6J42_RS16755	COG0626	cystathionine gamma-synthase activity
I6J42_RS16770	COG2814	Major facilitator Superfamily
I6J42_RS16795	COG0305	Participates in initiation and elongation during chromosome replication
I6J42_RS16805	COG0359	binds to the 23S rRNA
I6J42_RS16810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J42_RS16815	COG0629	single-stranded DNA binding
I6J42_RS16820	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J42_RS16845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J42_RS16865	COG0617	tRNA 3'-terminal CCA addition
I6J42_RS16880	COG2815	serine threonine protein kinase
I6J42_RS16880	COG0515	serine threonine protein kinase
I6J42_RS16885	COG1595	DNA-templated transcription, initiation
I6J42_RS16895	COG0492	ferredoxin-NADP+ reductase activity
I6J42_RS16900	COG3118	belongs to the thioredoxin family
I6J42_RS16915	COG1192	Involved in chromosome partitioning
I6J42_RS16920	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J42_RS16930	COG0706	membrane insertase activity
I6J42_RS16935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J42_RS16940	COG0594	ribonuclease P activity
I6J42_RS16955	COG0592	DNA-directed DNA polymerase activity
I6J42_RS16960	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J42_RS16965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J42_RS16970	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J42_RS16980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J42_RS16995	COG0582	viral genome integration into host DNA
I6J42_RS17040	COG0515	serine threonine protein kinase
I6J42_RS17080	COG3764	Sortase (surface protein transpeptidase)
I6J42_RS17095	COG3764	Sortase (surface protein transpeptidase)
I6J42_RS17100	COG3764	Sortase (surface protein transpeptidase)
I6J42_RS17105	COG0515	serine threonine protein kinase
I6J42_RS17110	COG0768	penicillin binding
I6J42_RS17125	COG1716	ATPase activity
I6J42_RS17130	COG1716	ATPase activity
I6J42_RS17165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J42_RS17170	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J42_RS17175	COG3396	Phenylacetate-CoA oxygenase
I6J42_RS17180	COG3460	Phenylacetate-CoA oxygenase
I6J42_RS17185	COG3396	Phenylacetate-CoA oxygenase
I6J42_RS17210	COG1309	transcriptional regulator
I6J42_RS17215	COG1522	sequence-specific DNA binding
I6J42_RS17240	COG0303	'Molybdopterin
I6J42_RS17265	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J42_RS17265	COG1136	(ABC) transporter
I6J42_RS17280	COG0515	serine threonine protein kinase
I6J42_RS17285	COG0515	serine threonine protein kinase
I6J42_RS17310	COG0022	dehydrogenase e1 component
I6J42_RS17315	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J42_RS17325	COG1802	Transcriptional regulator
I6J42_RS17330	COG2271	Major facilitator Superfamily
I6J42_RS17340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J42_RS17365	COG3903	Transcriptional regulator
I6J42_RS17365	COG3629	intracellular signal transduction
I6J42_RS17375	COG1362	aminopeptidase activity
I6J42_RS17385	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS17395	COG1741	Belongs to the pirin family
I6J42_RS17410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J42_RS17425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J42_RS17430	COG0745	RESPONSE REGULATOR receiver
I6J42_RS17435	COG2205	protein histidine kinase activity
I6J42_RS17440	COG2304	oxidoreductase activity
I6J42_RS17465	COG0431	NADPH-dependent FMN reductase
I6J42_RS17500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS17505	COG0180	Tryptophanyl-tRNA synthetase
I6J42_RS17515	COG2255	four-way junction helicase activity
I6J42_RS17540	COG0181	hydroxymethylbilane synthase activity
I6J42_RS17545	COG0475	glutathione-regulated potassium exporter activity
I6J42_RS17550	COG0490	domain, Protein
I6J42_RS17605	COG2268	Band 7 protein
I6J42_RS17615	COG0450	alkyl hydroperoxide reductase
I6J42_RS17665	COG1278	Cold shock
I6J42_RS17670	COG0513	Belongs to the DEAD box helicase family
I6J42_RS17680	COG2409	Drug exporters of the RND superfamily
I6J42_RS17745	COG0745	RESPONSE REGULATOR receiver
I6J42_RS17750	COG2205	protein histidine kinase activity
I6J42_RS17820	COG1278	Cold shock
I6J42_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS17830	COG1309	transcriptional regulator
I6J42_RS17850	COG3209	COG3209 Rhs family protein
I6J42_RS17890	COG0717	Belongs to the dCTP deaminase family
I6J42_RS17910	COG0247	lactate metabolic process
I6J42_RS17910	COG2181	nitrate reductase activity
I6J42_RS17915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J42_RS17920	COG0443	Heat shock 70 kDa protein
I6J42_RS17925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J42_RS17930	COG0484	heat shock protein binding
I6J42_RS17935	COG0789	Transcriptional regulator
I6J42_RS17980	COG0542	response to heat
I6J42_RS18000	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6J42_RS18015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J42_RS18020	COG0191	fructose-bisphosphate aldolase activity
I6J42_RS18025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J42_RS18030	COG0477	Major facilitator Superfamily
I6J42_RS18045	COG3844	kynureninase activity
I6J42_RS18055	COG0702	epimerase
I6J42_RS18060	COG4585	Histidine kinase
I6J42_RS18065	COG2197	response regulator
I6J42_RS18070	COG2124	cytochrome p450
I6J42_RS18090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J42_RS18120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J42_RS18130	COG0590	tRNA wobble adenosine to inosine editing
I6J42_RS18185	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS18190	COG0662	Cupin 2, conserved barrel domain protein
I6J42_RS18200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS18225	COG0667	Aldo Keto reductase
I6J42_RS18230	COG3226	Transcriptional regulator
I6J42_RS18235	COG0738	Major facilitator superfamily
I6J42_RS18245	COG2124	cytochrome p450
I6J42_RS18255	COG0693	protein deglycase activity
I6J42_RS18260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J42_RS18265	COG1802	Transcriptional regulator
I6J42_RS18280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J42_RS18285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J42_RS18295	COG0702	epimerase
I6J42_RS18325	COG1595	DNA-templated transcription, initiation
I6J42_RS18345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J42_RS18355	COG2755	lipolytic protein G-D-S-L family
I6J42_RS18360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J42_RS18375	COG1408	metallophosphoesterase
I6J42_RS18380	COG1610	YqeY-like protein
I6J42_RS18385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J42_RS18395	COG0003	Pfam Anion-transporting ATPase
I6J42_RS18410	COG0251	oxidation-reduction process
I6J42_RS18420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J42_RS18445	COG2267	carboxylic ester hydrolase activity
I6J42_RS18455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J42_RS18460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J42_RS18520	COG1111	helicase
I6J42_RS18520	COG1205	dead DEAH box helicase
I6J42_RS18525	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS18535	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J42_RS18545	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J42_RS18555	COG1754	DNA topoisomerase type I activity
I6J42_RS18555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J42_RS18560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J42_RS18565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J42_RS18610	COG2197	response regulator
I6J42_RS18620	COG0577	efflux transmembrane transporter activity
I6J42_RS18620	COG1136	(ABC) transporter
I6J42_RS18660	COG2197	response regulator
I6J42_RS18685	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6J42_RS18700	COG0463	Glycosyl transferase, family 2
I6J42_RS18750	COG1132	(ABC) transporter
I6J42_RS18765	COG2319	Wd-40 repeat
I6J42_RS18765	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J42_RS18770	COG1595	DNA-templated transcription, initiation
I6J42_RS18830	COG0546	phosphoglycolate phosphatase activity
I6J42_RS18835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J42_RS18850	COG2318	DinB family
I6J42_RS18870	COG0395	ABC-type sugar transport system, permease component
I6J42_RS18875	COG1175	transmembrane transport
I6J42_RS18915	COG4251	negative regulation of phosphorylation
I6J42_RS18920	COG2204	response regulator
I6J42_RS18965	COG4257	antibiotic catabolic process
I6J42_RS18990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J42_RS18995	COG1737	Transcriptional regulator
I6J42_RS19015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J42_RS19020	COG0640	Transcriptional regulator
I6J42_RS19025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J42_RS19035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J42_RS19045	COG1984	allophanate hydrolase subunit 2
I6J42_RS19065	COG3973	AAA domain
I6J42_RS19095	COG1120	ATPase activity
I6J42_RS19105	COG1061	Type III restriction enzyme res subunit
I6J42_RS19155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J42_RS19160	COG1120	ATPase activity
I6J42_RS19165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS19170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS19195	COG1278	Cold shock
I6J42_RS19205	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J42_RS19210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J42_RS19220	COG2814	Major facilitator Superfamily
I6J42_RS19240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J42_RS19250	COG2252	PERMEase
I6J42_RS19280	COG1309	transcriptional regulator
I6J42_RS19285	COG0667	Aldo Keto reductase
I6J42_RS19300	COG0671	phosphoesterase, PA-phosphatase related
I6J42_RS19340	COG2267	carboxylic ester hydrolase activity
I6J42_RS19380	COG0515	serine threonine protein kinase
I6J42_RS19385	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS19390	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS19430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J42_RS19470	COG0018	arginyl-trna synthetase
I6J42_RS19475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6J42_RS19540	COG1690	Belongs to the RtcB family
I6J42_RS19545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J42_RS19575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J42_RS19580	COG0406	alpha-ribazole phosphatase activity
I6J42_RS19590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J42_RS19595	COG0785	Cytochrome C biogenesis protein
I6J42_RS19600	COG1333	cytochrome c biogenesis protein
I6J42_RS19605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J42_RS19615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J42_RS19630	COG0163	prenyltransferase activity
I6J42_RS19640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J42_RS19650	COG1301	dicarboxylic acid transport
I6J42_RS19660	COG1309	transcriptional regulator
I6J42_RS19680	COG2208	phosphoserine phosphatase activity
I6J42_RS19680	COG2770	Histidine kinase
I6J42_RS19695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS19700	COG0183	Belongs to the thiolase family
I6J42_RS19710	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
I6J42_RS19730	COG0741	lytic transglycosylase activity
I6J42_RS19730	COG0739	heme binding
I6J42_RS19730	COG1196	nuclear chromosome segregation
I6J42_RS19830	COG0768	penicillin binding
I6J42_RS19835	COG3386	PFAM SMP-30 Gluconolaconase
I6J42_RS19850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J42_RS19955	COG1686	Belongs to the peptidase S11 family
I6J42_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS20015	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS20035	COG1846	Transcriptional regulator
I6J42_RS20040	COG3384	dioxygenase
I6J42_RS20060	COG0477	Major facilitator Superfamily
I6J42_RS20080	COG0243	molybdopterin cofactor binding
I6J42_RS20085	COG0437	4 iron, 4 sulfur cluster binding
I6J42_RS20110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J42_RS20135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J42_RS20140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J42_RS20150	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J42_RS20155	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J42_RS20175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J42_RS20195	COG2340	Cysteine-rich secretory protein family
I6J42_RS20225	COG0708	Exodeoxyribonuclease III
I6J42_RS20235	COG2072	flavoprotein involved in K transport
I6J42_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS20255	COG0793	Belongs to the peptidase S41A family
I6J42_RS20255	COG4946	Tricorn protease homolog
I6J42_RS20265	COG2409	Drug exporters of the RND superfamily
I6J42_RS20275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J42_RS20280	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS20300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J42_RS20305	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I6J42_RS20325	COG0442	prolyl-tRNA aminoacylation
I6J42_RS20330	COG2207	Transcriptional regulator
I6J42_RS20335	COG2223	nitrite transmembrane transporter activity
I6J42_RS20380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J42_RS20410	COG0084	hydrolase, TatD family'
I6J42_RS20415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J42_RS20420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J42_RS20435	COG4115	mRNA cleavage
I6J42_RS20440	COG2161	toxin-antitoxin pair type II binding
I6J42_RS20460	COG0488	(ABC) transporter
I6J42_RS20485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J42_RS20500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J42_RS20510	COG2197	response regulator
I6J42_RS20515	COG1846	Transcriptional regulator
I6J42_RS20520	COG4106	trans-aconitate 2-methyltransferase activity
I6J42_RS20545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J42_RS20550	COG0193	aminoacyl-tRNA hydrolase activity
I6J42_RS20555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J42_RS20560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J42_RS20565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J42_RS20575	COG4585	Histidine kinase
I6J42_RS20590	COG2226	methyltransferase
I6J42_RS20620	COG2124	cytochrome p450
I6J42_RS20665	COG0346	lactoylglutathione lyase activity
I6J42_RS20670	COG0477	Major facilitator Superfamily
I6J42_RS20675	COG1136	(ABC) transporter
I6J42_RS20680	COG0577	efflux transmembrane transporter activity
I6J42_RS20690	COG3629	intracellular signal transduction
I6J42_RS20690	COG3903	Transcriptional regulator
I6J42_RS20745	COG1473	amidohydrolase
I6J42_RS20790	COG1335	isochorismatase
I6J42_RS20810	COG0515	serine threonine protein kinase
I6J42_RS20810	COG2815	serine threonine protein kinase
I6J42_RS20835	COG1652	LysM domain
I6J42_RS20845	COG0148	phosphopyruvate hydratase activity
I6J42_RS20865	COG1252	NADH dehydrogenase
I6J42_RS20870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J42_RS20875	COG1136	(ABC) transporter
I6J42_RS20875	COG0577	efflux transmembrane transporter activity
I6J42_RS20880	COG1136	(ABC) transporter
I6J42_RS20905	COG0183	Belongs to the thiolase family
I6J42_RS20910	COG2755	lipolytic protein G-D-S-L family
I6J42_RS20950	COG0531	amino acid
I6J42_RS20955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J42_RS20960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J42_RS20970	COG1228	amidohydrolase
I6J42_RS20975	COG1191	sigma factor activity
I6J42_RS20980	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J42_RS21010	COG3104	oligopeptide transport
I6J42_RS21015	COG0745	RESPONSE REGULATOR receiver
I6J42_RS21020	COG2205	protein histidine kinase activity
I6J42_RS21050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J42_RS21120	COG1316	TRANSCRIPTIONal
I6J42_RS21130	COG1316	TRANSCRIPTIONal
I6J42_RS21135	COG1316	TRANSCRIPTIONal
I6J42_RS21140	COG1316	TRANSCRIPTIONal
I6J42_RS21145	COG1316	TRANSCRIPTIONal
I6J42_RS21170	COG0531	amino acid
I6J42_RS21175	COG0778	Nitroreductase
I6J42_RS21175	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J42_RS21180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J42_RS21215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J42_RS21220	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J42_RS21240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J42_RS21280	COG0714	Associated with various cellular activities
I6J42_RS21300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J42_RS21360	COG2188	Transcriptional regulator
I6J42_RS21365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J42_RS21385	COG0745	RESPONSE REGULATOR receiver
I6J42_RS21390	COG5002	protein histidine kinase activity
I6J42_RS21390	COG5000	phosphorelay sensor kinase activity
I6J42_RS21395	COG0823	Involved in the tonB-independent uptake of proteins
I6J42_RS21405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J42_RS21410	COG2197	response regulator
I6J42_RS21425	COG0653	protein targeting
I6J42_RS21445	COG2902	Dehydrogenase
I6J42_RS21450	COG1134	teichoic acid transport
I6J42_RS21460	COG1309	transcriptional regulator
I6J42_RS21470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J42_RS21475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J42_RS21480	COG1073	alpha beta
I6J42_RS21480	COG2226	methyltransferase
I6J42_RS21485	COG4122	O-methyltransferase activity
I6J42_RS21490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J42_RS21495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J42_RS21500	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS21505	COG1442	glycosyl transferase family 8
I6J42_RS21505	COG1216	Glycosyl transferase, family 2
I6J42_RS21510	COG0395	ABC-type sugar transport system, permease component
I6J42_RS21515	COG1175	transmembrane transport
I6J42_RS21520	COG1653	transport
I6J42_RS21530	COG0515	serine threonine protein kinase
I6J42_RS21535	COG0515	serine threonine protein kinase
I6J42_RS21540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J42_RS21555	COG2884	Cell division ATP-binding protein ftsE
I6J42_RS21560	COG2177	Part of the ABC transporter FtsEX involved in
I6J42_RS21565	COG0793	Belongs to the peptidase S41A family
I6J42_RS21570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J42_RS21615	COG0583	DNA-binding transcription factor activity
I6J42_RS21620	COG2223	nitrite transmembrane transporter activity
I6J42_RS21645	COG3973	AAA domain
I6J42_RS21645	COG3973	AAA domain
I6J42_RS21655	COG0776	regulation of translation
I6J42_RS21660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J42_RS21665	COG1678	Uncharacterized ACR, COG1678
I6J42_RS21675	COG2182	Extracellular solute-binding protein
I6J42_RS21680	COG1175	transmembrane transport
I6J42_RS21685	COG0395	ABC-type sugar transport system, permease component
I6J42_RS21690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J42_RS21750	COG3654	unkown
I6J42_RS21785	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J42_RS21805	COG1732	Glycine betaine
I6J42_RS21810	COG1174	glycine betaine transport
I6J42_RS21815	COG0517	IMP dehydrogenase activity
I6J42_RS21815	COG1125	glycine betaine transport
I6J42_RS21820	COG1174	glycine betaine transport
I6J42_RS21830	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J42_RS21840	COG0277	FAD linked oxidase domain protein
I6J42_RS21875	COG1335	isochorismatase
I6J42_RS21885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J42_RS21895	COG1113	amino acid transport
I6J42_RS21910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS21935	COG1234	tRNA 3'-trailer cleavage
I6J42_RS21945	COG1263	PTS System
I6J42_RS21950	COG1263	PTS System
I6J42_RS21955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J42_RS21960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J42_RS21970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J42_RS21990	COG0477	Major facilitator Superfamily
I6J42_RS22015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J42_RS22030	COG4555	ABC transporter
I6J42_RS22045	COG2733	membrane
I6J42_RS22055	COG0596	Alpha beta hydrolase
I6J42_RS22065	COG2175	clavaminate synthase activity
I6J42_RS22080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J42_RS22085	COG3135	benzoate transporter
I6J42_RS22115	COG3655	Transcriptional regulator
I6J42_RS22155	COG3764	Sortase (surface protein transpeptidase)
I6J42_RS22165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J42_RS22175	COG0706	membrane insertase activity
I6J42_RS22175	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
I6J42_RS22180	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J42_RS22185	COG4702	Belongs to the UPF0303 family
I6J42_RS22190	COG0673	inositol 2-dehydrogenase activity
I6J42_RS22195	COG1940	carbohydrate kinase activity
I6J42_RS22205	COG2188	Transcriptional regulator
I6J42_RS22210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J42_RS22275	COG3397	chitin binding
I6J42_RS22285	COG1414	Transcriptional regulator
I6J42_RS22290	COG1126	abc transporter atp-binding protein
I6J42_RS22295	COG0765	amino acid transport
I6J42_RS22300	COG0765	amino acid transport
I6J42_RS22305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS22315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J42_RS22325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS22400	COG0745	RESPONSE REGULATOR receiver
I6J42_RS22415	COG2985	domain, Protein
I6J42_RS22430	COG0395	ABC-type sugar transport system, permease component
I6J42_RS22465	COG4977	sequence-specific DNA binding
I6J42_RS22475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J42_RS22500	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J42_RS22505	COG0076	glutamate decarboxylase activity
I6J42_RS22525	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS22540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J42_RS22545	COG1309	transcriptional regulator
I6J42_RS22575	COG1946	Acyl-CoA thioesterase
I6J42_RS22600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J42_RS22635	COG0028	Belongs to the TPP enzyme family
I6J42_RS22665	COG0477	Major facilitator Superfamily
I6J42_RS22680	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J42_RS22705	COG1404	Belongs to the peptidase S8 family
I6J42_RS22740	COG0515	serine threonine protein kinase
I6J42_RS22775	COG1609	Transcriptional regulator
I6J42_RS22780	COG0673	inositol 2-dehydrogenase activity
I6J42_RS22830	COG0596	Alpha beta hydrolase
I6J42_RS22855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J42_RS22895	COG2318	DinB family
I6J42_RS22905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J42_RS22915	COG3718	enzyme involved in inositol metabolism
I6J42_RS22920	COG3962	Belongs to the TPP enzyme family
I6J42_RS22940	COG4585	Histidine kinase
I6J42_RS22945	COG2197	response regulator
I6J42_RS23040	COG1674	ftsk spoiiie
I6J42_RS23075	COG0629	single-stranded DNA binding
I6J42_RS23100	COG0577	efflux transmembrane transporter activity
I6J42_RS23100	COG1136	(ABC) transporter
I6J42_RS23120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J42_RS23150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS23165	COG1486	melibiose metabolic process
I6J42_RS23170	COG0395	ABC-type sugar transport system, permease component
I6J42_RS23175	COG1175	transmembrane transport
I6J42_RS23185	COG1940	carbohydrate kinase activity
I6J42_RS23205	COG0668	transmembrane transport
I6J42_RS23215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J42_RS23215	COG3291	Pkd domain containing protein
I6J42_RS23235	COG0583	DNA-binding transcription factor activity
I6J42_RS23240	COG4266	Belongs to the allantoicase family
I6J42_RS23265	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J42_RS23290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J42_RS23300	COG2252	PERMEase
I6J42_RS23320	COG1404	Belongs to the peptidase S8 family
I6J42_RS23325	COG0110	maltose O-acetyltransferase activity
I6J42_RS23340	COG0640	Transcriptional regulator
I6J42_RS23345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J42_RS23355	COG0783	Belongs to the Dps family
I6J42_RS23360	COG0584	glycerophosphoryl diester phosphodiesterase
I6J42_RS23370	COG1113	amino acid transport
I6J42_RS23375	COG1268	BioY protein
I6J42_RS23385	COG1113	amino acid transport
I6J42_RS23405	COG0475	glutathione-regulated potassium exporter activity
I6J42_RS23415	COG3594	Acyltransferase
I6J42_RS23435	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J42_RS23440	COG0740	serine-type endopeptidase activity
I6J42_RS23445	COG0740	serine-type endopeptidase activity
I6J42_RS23450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J42_RS23460	COG0525	valine-tRNA ligase activity
I6J42_RS23465	COG0285	dihydrofolate synthase activity
I6J42_RS23475	COG0105	UTP biosynthetic process
I6J42_RS23480	COG1077	Cell shape determining protein MreB Mrl
I6J42_RS23495	COG0768	penicillin binding
I6J42_RS23500	COG0772	Belongs to the SEDS family
I6J42_RS23525	COG1530	ribonuclease E activity
I6J42_RS23530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J42_RS23535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J42_RS23540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J42_RS23565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J42_RS23575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J42_RS23590	COG0501	Belongs to the peptidase M48B family
I6J42_RS23605	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J42_RS23615	COG0799	negative regulation of ribosome biogenesis
I6J42_RS23620	COG0588	phosphoglycerate mutase activity
I6J42_RS23640	COG0495	leucyl-tRNA aminoacylation
I6J42_RS23650	COG1307	EDD domain protein, DegV family
I6J42_RS23655	COG1555	photosystem II stabilization
I6J42_RS23685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J42_RS23690	COG0210	DNA helicase
I6J42_RS23725	COG0268	Binds directly to 16S ribosomal RNA
I6J42_RS23730	COG0481	GTPase activity
I6J42_RS23770	COG1420	regulation of RNA biosynthetic process
I6J42_RS23775	COG0484	heat shock protein binding
I6J42_RS23790	COG0537	adenosine 5'-monophosphoramidase activity
I6J42_RS23795	COG1234	tRNA 3'-trailer cleavage
I6J42_RS23800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J42_RS23810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J42_RS23810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J42_RS23820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J42_RS23830	COG2315	Protein conserved in bacteria
I6J42_RS23845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J42_RS23860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J42_RS23870	COG1381	Involved in DNA repair and RecF pathway recombination
I6J42_RS23875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J42_RS23885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J42_RS23890	COG1121	(ABC) transporter
I6J42_RS23900	COG0423	glycine-tRNA ligase activity
I6J42_RS23910	COG3104	oligopeptide transport
I6J42_RS23925	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS23930	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS23935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS23940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS23945	COG0662	Cupin 2, conserved barrel domain protein
I6J42_RS23955	COG0367	asparagine synthase
I6J42_RS23980	COG2345	Transcriptional regulator
I6J42_RS23985	COG0477	Major facilitator Superfamily
I6J42_RS24020	COG2124	cytochrome p450
I6J42_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS24030	COG0277	FAD linked oxidase domain protein
I6J42_RS24045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J42_RS24175	COG1309	transcriptional regulator
I6J42_RS24190	COG2066	Belongs to the glutaminase family
I6J42_RS24195	COG0477	Major facilitator Superfamily
I6J42_RS24225	COG2188	Transcriptional regulator
I6J42_RS24245	COG3842	ATPase activity
I6J42_RS24250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS24255	COG0574	Belongs to the PEP-utilizing enzyme family
I6J42_RS24255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J42_RS24280	COG2146	nitrite reductase [NAD(P)H] activity
I6J42_RS24280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J42_RS24325	COG2949	membrane
I6J42_RS24335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J42_RS24345	COG0358	DNA primase activity
I6J42_RS24350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J42_RS24365	COG1070	Carbohydrate kinase
I6J42_RS24390	COG0477	Major facilitator Superfamily
I6J42_RS24395	COG0825	malonyl-CoA metabolic process
I6J42_RS24395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J42_RS24400	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS24410	COG1522	sequence-specific DNA binding
I6J42_RS24440	COG2130	NADP-dependent
I6J42_RS24445	COG1764	response to oxidative stress
I6J42_RS24470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS24475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J42_RS24480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J42_RS24525	COG1741	Belongs to the pirin family
I6J42_RS24535	COG0456	acetyltransferase
I6J42_RS24540	COG2957	Belongs to the agmatine deiminase family
I6J42_RS24595	COG1404	Belongs to the peptidase S8 family
I6J42_RS24600	COG1674	ftsk spoiiie
I6J42_RS24675	COG1929	Belongs to the glycerate kinase type-1 family
I6J42_RS24685	COG0667	Aldo Keto reductase
I6J42_RS24695	COG0745	RESPONSE REGULATOR receiver
I6J42_RS24700	COG2205	protein histidine kinase activity
I6J42_RS24710	COG0789	Transcriptional regulator
I6J42_RS24715	COG0667	Aldo Keto reductase
I6J42_RS24730	COG2197	response regulator
I6J42_RS24735	COG4585	Histidine kinase
I6J42_RS24750	COG1309	transcriptional regulator
I6J42_RS24755	COG0477	Major facilitator Superfamily
I6J42_RS24765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J42_RS24810	COG1358	cellular component organization or biogenesis
I6J42_RS24890	COG2259	Doxx family
I6J42_RS24935	COG2124	cytochrome p450
I6J42_RS24940	COG0183	Belongs to the thiolase family
I6J42_RS24955	COG3845	ABC transporter
I6J42_RS25015	COG1309	transcriptional regulator
I6J42_RS25020	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS25045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS25065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J42_RS25070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J42_RS25085	COG3340	Belongs to the peptidase S51 family
I6J42_RS25095	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS25100	COG0183	Belongs to the thiolase family
I6J42_RS25105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J42_RS25115	COG2030	dehydratase
I6J42_RS25125	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS25140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J42_RS25145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J42_RS25160	COG0800	Aldolase
I6J42_RS25165	COG3022	response to hydroperoxide
I6J42_RS25190	COG2273	Hydrolase Family 16
I6J42_RS25230	COG0384	phenazine biosynthesis protein PhzF
I6J42_RS25240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS25245	COG3540	Alkaline phosphatase
I6J42_RS25255	COG2814	Major facilitator Superfamily
I6J42_RS25270	COG1834	amidinotransferase
I6J42_RS25290	COG1120	ATPase activity
I6J42_RS25295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS25355	COG1994	Peptidase M50
I6J42_RS25375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J42_RS25380	COG0477	Major facilitator Superfamily
I6J42_RS25395	COG2814	Major facilitator Superfamily
I6J42_RS25400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J42_RS25400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J42_RS25405	COG2132	Multicopper oxidase
I6J42_RS25420	COG0174	glutamine synthetase
I6J42_RS25455	COG2188	Transcriptional regulator
I6J42_RS25480	COG0494	nUDIX hydrolase
I6J42_RS25520	COG0477	Major facilitator Superfamily
I6J42_RS25525	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J42_RS25530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J42_RS25540	COG1609	Transcriptional regulator
I6J42_RS25545	COG2182	Extracellular solute-binding protein
I6J42_RS25555	COG0395	ABC-type sugar transport system, permease component
I6J42_RS25560	COG0366	Alpha amylase catalytic
I6J42_RS25620	COG2197	response regulator
I6J42_RS25625	COG4585	Histidine kinase
I6J42_RS25630	COG2409	Drug exporters of the RND superfamily
I6J42_RS25635	COG0745	RESPONSE REGULATOR receiver
I6J42_RS25655	COG0673	inositol 2-dehydrogenase activity
I6J42_RS25660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J42_RS25690	COG3896	Chloramphenicol phosphotransferase-like protein
I6J42_RS25695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J42_RS25720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J42_RS25740	COG1090	epimerase
I6J42_RS25760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J42_RS25770	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J42_RS25775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J42_RS25780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J42_RS25785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J42_RS25800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J42_RS25815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J42_RS25840	COG4585	Histidine kinase
I6J42_RS25845	COG2197	response regulator
I6J42_RS25850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J42_RS25860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J42_RS25880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J42_RS25890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J42_RS25895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J42_RS25905	COG1376	ErfK ybiS ycfS ynhG family protein
I6J42_RS25915	COG1845	cytochrome c oxidase, subunit III
I6J42_RS25920	COG2010	Cytochrome c
I6J42_RS25925	COG0723	plastoquinol--plastocyanin reductase activity
I6J42_RS25930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J42_RS25935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J42_RS25940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J42_RS25990	COG1022	Amp-dependent synthetase and ligase
I6J42_RS26005	COG0003	Pfam Anion-transporting ATPase
I6J42_RS26015	COG1940	carbohydrate kinase activity
I6J42_RS26045	COG2197	response regulator
I6J42_RS26050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J42_RS26065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J42_RS26075	COG2193	ferroxidase activity
I6J42_RS26080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J42_RS26085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J42_RS26090	COG2815	serine threonine protein kinase
I6J42_RS26090	COG0515	serine threonine protein kinase
I6J42_RS26095	COG2022	thiamine diphosphate biosynthetic process
I6J42_RS26105	COG2022	thiamine diphosphate biosynthetic process
I6J42_RS26105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J42_RS26125	COG0352	thiamine-phosphate diphosphorylase activity
I6J42_RS26140	COG1233	COG1233 Phytoene dehydrogenase and related
I6J42_RS26160	COG1136	(ABC) transporter
I6J42_RS26160	COG0577	efflux transmembrane transporter activity
I6J42_RS26170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J42_RS26190	COG0714	Associated with various cellular activities
I6J42_RS26200	COG0275	rRNA processing
I6J42_RS26210	COG0768	penicillin binding
I6J42_RS26215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J42_RS26225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J42_RS26230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J42_RS26240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J42_RS26260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J42_RS26265	COG1799	cell septum assembly
I6J42_RS26275	COG3599	regulation of cell shape
I6J42_RS26280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J42_RS26290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J42_RS26335	COG0587	DNA-directed DNA polymerase activity
I6J42_RS26345	COG1432	Conserved Protein
I6J42_RS26370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J42_RS26390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J42_RS26395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J42_RS26400	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J42_RS26410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J42_RS26415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J42_RS26420	COG0251	oxidation-reduction process
I6J42_RS26425	COG0107	imidazoleglycerol-phosphate synthase activity
I6J42_RS26445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J42_RS26450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J42_RS26470	COG0134	indole-3-glycerol-phosphate synthase activity
I6J42_RS26480	COG0133	tryptophan synthase activity
I6J42_RS26485	COG0159	tryptophan synthase activity
I6J42_RS26495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J42_RS26505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J42_RS26510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J42_RS26540	COG0067	glutamate synthase
I6J42_RS26540	COG0069	glutamate synthase activity
I6J42_RS26540	COG0070	glutamate synthase
I6J42_RS26550	COG0705	Rhomboid family
I6J42_RS26580	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS26590	COG1309	transcriptional regulator
I6J42_RS26595	COG0183	Belongs to the thiolase family
I6J42_RS26600	COG1278	Cold shock
I6J42_RS26625	COG1024	Enoyl-CoA hydratase
I6J42_RS26630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS26665	COG1605	Chorismate mutase
I6J42_RS26665	COG0287	Prephenate dehydrogenase
I6J42_RS26700	COG0737	Belongs to the 5'-nucleotidase family
I6J42_RS26745	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J42_RS26755	COG2050	protein possibly involved in aromatic compounds catabolism
I6J42_RS26790	COG1643	Atp-dependent helicase
I6J42_RS26815	COG0237	dephospho-CoA kinase activity
I6J42_RS26835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J42_RS26845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J42_RS26865	COG0436	Aminotransferase
I6J42_RS26885	COG2313	pseudouridylate synthase activity
I6J42_RS26895	COG2814	Major facilitator Superfamily
I6J42_RS26905	COG0584	glycerophosphoryl diester phosphodiesterase
I6J42_RS26915	COG0556	nucleotide-excision repair
I6J42_RS26945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J42_RS26970	COG0322	excinuclease ABC activity
I6J42_RS26975	COG1660	Displays ATPase and GTPase activities
I6J42_RS26980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J42_RS26985	COG1481	regulation of sporulation
I6J42_RS26990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J42_RS26995	COG0126	phosphoglycerate kinase activity
I6J42_RS27000	COG0149	triose-phosphate isomerase activity
I6J42_RS27005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J42_RS27015	COG0166	Belongs to the GPI family
I6J42_RS27030	COG4195	phage-related replication protein
I6J42_RS27040	COG0363	glucosamine-6-phosphate deaminase activity
I6J42_RS27055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J42_RS27065	COG0109	protoheme IX farnesyltransferase activity
I6J42_RS27100	COG0719	Fe-S assembly protein
I6J42_RS27110	COG0396	ATPase activity
I6J42_RS27115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J42_RS27120	COG0822	iron-sulfur transferase activity
I6J42_RS27125	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J42_RS27140	COG3226	Transcriptional regulator
I6J42_RS27145	COG2171	N-acyltransferase activity
I6J42_RS27150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J42_RS27190	COG0768	penicillin binding
I6J42_RS27195	COG2197	response regulator
I6J42_RS27200	COG4585	Histidine kinase
I6J42_RS27250	COG1902	pentaerythritol trinitrate reductase activity
I6J42_RS27280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J42_RS27305	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J42_RS27320	COG1492	cobalamin metabolic process
I6J42_RS27325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J42_RS27340	COG0235	Class ii aldolase
I6J42_RS27365	COG0488	(ABC) transporter
I6J42_RS27375	COG1024	Enoyl-CoA hydratase
I6J42_RS27415	COG3387	PFAM Glycoside hydrolase 15-related
I6J42_RS27455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J42_RS27460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J42_RS27475	COG2261	transglycosylase associated protein
I6J42_RS27480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J42_RS27505	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS27510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J42_RS27540	COG3830	Belongs to the UPF0237 family
I6J42_RS27540	COG0560	Phosphoserine phosphatase
I6J42_RS27545	COG1131	(ABC) transporter
I6J42_RS27545	COG0842	Transport permease protein
I6J42_RS27545	COG1716	ATPase activity
I6J42_RS27555	COG4585	Histidine kinase
I6J42_RS27560	COG2197	response regulator
I6J42_RS27570	COG1119	ATPase activity
I6J42_RS27595	COG1881	PFAM PEBP family protein
I6J42_RS27605	COG2094	Belongs to the DNA glycosylase MPG family
I6J42_RS27640	COG0647	UMP catabolic process
I6J42_RS27645	COG1120	ATPase activity
I6J42_RS27665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J42_RS27670	COG0497	DNA recombination
I6J42_RS27695	COG3387	PFAM Glycoside hydrolase 15-related
I6J42_RS27700	COG0504	CTP synthase activity
I6J42_RS27705	COG0494	nUDIX hydrolase
I6J42_RS27715	COG0686	Belongs to the AlaDH PNT family
I6J42_RS27730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J42_RS27735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J42_RS27740	COG1187	pseudouridine synthase activity
I6J42_RS27755	COG0494	nUDIX hydrolase
I6J42_RS27780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J42_RS27790	COG1160	GTP binding
I6J42_RS27805	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS27820	COG0671	phosphoesterase, PA-phosphatase related
I6J42_RS27825	COG0477	Major facilitator Superfamily
I6J42_RS27830	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS27835	COG1799	cell septum assembly
I6J42_RS27845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS27850	COG0765	amino acid transport
I6J42_RS27865	COG1126	abc transporter atp-binding protein
I6J42_RS27870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J42_RS27875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS27880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS27915	COG0641	radical SAM
I6J42_RS27935	COG2197	response regulator
I6J42_RS27940	COG4585	Histidine kinase
I6J42_RS27975	COG4565	transcriptional regulatory protein
I6J42_RS27995	COG0346	lactoylglutathione lyase activity
I6J42_RS28010	COG1725	Transcriptional regulator
I6J42_RS28020	COG2755	lipolytic protein G-D-S-L family
I6J42_RS28030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J42_RS28040	COG2188	Transcriptional regulator
I6J42_RS28045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6J42_RS28065	COG1309	transcriptional regulator
I6J42_RS28070	COG2851	Citrate transporter
I6J42_RS28080	COG2318	DinB family
I6J42_RS28090	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J42_RS28105	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS28140	COG3876	Protein conserved in bacteria
I6J42_RS28145	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS28150	COG0318	PFAM AMP-dependent synthetase and ligase
I6J42_RS28160	COG4935	Belongs to the peptidase S8 family
I6J42_RS28160	COG2234	aminopeptidase activity
I6J42_RS28165	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS28185	COG2149	membrane
I6J42_RS28190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J42_RS28220	COG3265	gluconokinase activity
I6J42_RS28225	COG2186	Transcriptional regulator
I6J42_RS28240	COG0564	pseudouridine synthase activity
I6J42_RS28250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J42_RS28280	COG0667	Aldo Keto reductase
I6J42_RS28285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS28295	COG0598	Magnesium transport protein CorA
I6J42_RS28315	COG0215	cysteine-tRNA ligase activity
I6J42_RS28325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS28330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J42_RS28335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J42_RS28340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J42_RS28345	COG1414	Transcriptional regulator
I6J42_RS28350	COG1410	methionine synthase
I6J42_RS28350	COG0646	methionine synthase
I6J42_RS28355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS28360	COG4166	transmembrane transport
I6J42_RS28365	COG2197	response regulator
I6J42_RS28375	COG0517	IMP dehydrogenase activity
I6J42_RS28375	COG1994	Peptidase M50
I6J42_RS28395	COG1222	aaa ATPase
I6J42_RS28400	COG4122	O-methyltransferase activity
I6J42_RS28410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J42_RS28415	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J42_RS28420	COG1609	Transcriptional regulator
I6J42_RS28430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J42_RS28435	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J42_RS28445	COG2378	regulation of single-species biofilm formation
I6J42_RS28465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J42_RS28470	COG0805	protein transport
I6J42_RS28510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J42_RS28515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J42_RS28545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J42_RS28550	COG4175	Glycine betaine
I6J42_RS28550	COG0517	IMP dehydrogenase activity
I6J42_RS28605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J42_RS28615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J42_RS28620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J42_RS28625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J42_RS28630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J42_RS28635	COG5002	protein histidine kinase activity
I6J42_RS28640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J42_RS28645	COG0072	phenylalanine-tRNA ligase activity
I6J42_RS28645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J42_RS28670	COG1649	PFAM Uncharacterised BCR, COG1649
I6J42_RS28680	COG0697	spore germination
I6J42_RS28740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J42_RS28745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J42_RS28750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J42_RS28755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J42_RS28760	COG1438	arginine binding
I6J42_RS28775	COG0137	argininosuccinate synthase activity
I6J42_RS28780	COG0165	Argininosuccinate lyase
I6J42_RS28790	COG3973	AAA domain
I6J42_RS28800	COG0477	Major facilitator Superfamily
I6J42_RS28840	COG2011	ABC-type metal ion transport system permease component
I6J42_RS28845	COG1464	Belongs to the NlpA lipoprotein family
I6J42_RS28860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J42_RS28865	COG1648	precorrin-2 dehydrogenase activity
I6J42_RS28865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J42_RS28920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J42_RS28980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J42_RS28995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J42_RS29015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J42_RS29020	COG1560	Kdo2-lipid A biosynthetic process
I6J42_RS29025	COG0438	transferase activity, transferring glycosyl groups
I6J42_RS29035	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J42_RS29040	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J42_RS29045	COG0217	transcriptional regulatory protein
I6J42_RS29050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J42_RS29055	COG0632	four-way junction helicase activity
I6J42_RS29060	COG2255	four-way junction helicase activity
I6J42_RS29070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J42_RS29075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J42_RS29080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J42_RS29085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J42_RS29105	COG1196	nuclear chromosome segregation
I6J42_RS29120	COG0124	histidyl-tRNA synthetase
I6J42_RS29140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J42_RS29160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J42_RS29165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J42_RS29175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J42_RS29180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J42_RS29185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J42_RS29190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J42_RS29200	COG0006	proline dipeptidase activity
I6J42_RS29205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J42_RS29210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J42_RS29220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J42_RS29225	COG0540	Belongs to the ATCase OTCase family
I6J42_RS29230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J42_RS29240	COG0505	Belongs to the CarA family
I6J42_RS29245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J42_RS29250	COG0167	dihydroorotate dehydrogenase activity
I6J42_RS29255	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J42_RS29270	COG1758	RNA polymerase activity
I6J42_RS29280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J42_RS29295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J42_RS29305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J42_RS29310	COG2390	Transcriptional regulator
I6J42_RS29325	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS29335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J42_RS29350	COG0142	geranyltranstransferase activity
I6J42_RS29370	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J42_RS29385	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS29395	COG2233	PERMEase
I6J42_RS29400	COG0738	Major facilitator superfamily
I6J42_RS29425	COG3201	nicotinamide mononucleotide transporter
I6J42_RS29430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J42_RS29430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J42_RS29435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J42_RS29440	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J42_RS29445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J42_RS29490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J42_RS29500	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS29505	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS29525	COG1216	Glycosyl transferase, family 2
I6J42_RS29540	COG2270	Major facilitator Superfamily
I6J42_RS29550	COG2364	Membrane
I6J42_RS29615	COG2018	Roadblock/LC7 domain
I6J42_RS29645	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J42_RS29660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J42_RS29670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J42_RS29700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J42_RS29720	COG1716	ATPase activity
I6J42_RS29740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J42_RS29750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J42_RS29750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J42_RS29780	COG0384	phenazine biosynthesis protein PhzF
I6J42_RS29835	COG1595	DNA-templated transcription, initiation
I6J42_RS29860	COG1695	Transcriptional regulator
I6J42_RS29960	COG3800	Transcriptional regulator
I6J42_RS29960	COG1396	sequence-specific DNA binding
I6J42_RS29980	COG1215	transferase activity, transferring glycosyl groups
I6J42_RS29990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J42_RS30000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J42_RS30005	COG4251	negative regulation of phosphorylation
I6J42_RS30010	COG0784	Response regulator, receiver
I6J42_RS30025	COG0477	Major facilitator Superfamily
I6J42_RS30080	COG0069	glutamate synthase activity
I6J42_RS30140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J42_RS30205	COG2226	methyltransferase
I6J42_RS30240	COG1968	undecaprenyl-diphosphatase activity
I6J42_RS30260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J42_RS30300	COG1832	CoA-binding protein
I6J42_RS30305	COG1739	Uncharacterized protein family UPF0029
I6J42_RS30310	COG0420	3'-5' exonuclease activity
I6J42_RS30315	COG0419	ATPase involved in DNA repair
I6J42_RS30335	COG0626	cystathionine gamma-synthase activity
I6J42_RS30360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J42_RS30375	COG1595	DNA-templated transcription, initiation
I6J42_RS30380	COG2188	Transcriptional regulator
I6J42_RS30385	COG1940	carbohydrate kinase activity
I6J42_RS30395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J42_RS30440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J42_RS30445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J42_RS30450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J42_RS30455	COG0156	8-amino-7-oxononanoate synthase activity
I6J42_RS30475	COG0583	DNA-binding transcription factor activity
I6J42_RS30480	COG1280	lysine exporter protein (LysE YggA)
I6J42_RS30495	COG0740	serine-type endopeptidase activity
I6J42_RS30510	COG1309	transcriptional regulator
I6J42_RS30515	COG0831	urea catabolic process
I6J42_RS30520	COG0832	Belongs to the urease beta subunit family
I6J42_RS30525	COG0804	urea catabolic process
I6J42_RS30535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J42_RS30540	COG0829	nickel cation binding
I6J42_RS30555	COG0204	Acyl-transferase
I6J42_RS30570	COG0205	6-phosphofructokinase activity
I6J42_RS30575	COG3442	glutamine amidotransferase
I6J42_RS30585	COG0242	peptide deformylase activity
I6J42_RS30595	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS30600	COG0386	Belongs to the glutathione peroxidase family
I6J42_RS30615	COG1946	Acyl-CoA thioesterase
I6J42_RS30630	COG1793	dna ligase
I6J42_RS30650	COG1132	(ABC) transporter
I6J42_RS30655	COG1132	(ABC) transporter
I6J42_RS30660	COG0673	inositol 2-dehydrogenase activity
I6J42_RS30665	COG0277	FAD linked oxidase domain protein
I6J42_RS30670	COG1846	Transcriptional regulator
I6J42_RS30675	COG1132	(ABC) transporter
I6J42_RS30685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J42_RS30690	COG2072	flavoprotein involved in K transport
I6J42_RS30705	COG1116	anion transmembrane transporter activity
I6J42_RS30710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J42_RS30720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J42_RS30745	COG1959	2 iron, 2 sulfur cluster binding
I6J42_RS30790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J42_RS30815	COG2814	Major facilitator Superfamily
I6J42_RS30870	COG1309	transcriptional regulator
I6J42_RS30885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS30890	COG1982	Orn Lys Arg decarboxylase major
I6J42_RS30895	COG1309	transcriptional regulator
I6J42_RS30920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J42_RS30975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J42_RS30990	COG1891	lyase activity
I6J42_RS31040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS31045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS31055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J42_RS31085	COG2080	2 iron, 2 sulfur cluster binding
I6J42_RS31090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J42_RS31095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J42_RS31125	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J42_RS31140	COG1335	isochorismatase
I6J42_RS31195	COG0542	response to heat
I6J42_RS31215	COG0402	S-adenosylhomocysteine deaminase activity
I6J42_RS31220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J42_RS31225	COG1802	Transcriptional regulator
I6J42_RS31235	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J42_RS31255	COG4981	capsule polysaccharide biosynthetic process
I6J42_RS31290	COG1012	belongs to the aldehyde dehydrogenase family
I6J42_RS31295	COG0174	glutamine synthetase
I6J42_RS31305	COG0531	amino acid
I6J42_RS31310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J42_RS31345	COG1253	flavin adenine dinucleotide binding
I6J42_RS31370	COG0667	Aldo Keto reductase
I6J42_RS31375	COG0515	serine threonine protein kinase
I6J42_RS31375	COG2815	serine threonine protein kinase
I6J42_RS31430	COG0107	imidazoleglycerol-phosphate synthase activity
I6J42_RS31450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J42_RS31455	COG3483	tryptophan 2,3-dioxygenase activity
I6J42_RS31460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J42_RS31475	COG2197	response regulator
I6J42_RS31480	COG3961	Belongs to the TPP enzyme family
I6J42_RS31525	COG2706	6-phosphogluconolactonase activity
I6J42_RS31540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J42_RS31585	COG0671	phosphoesterase, PA-phosphatase related
I6J42_RS31605	COG0584	glycerophosphoryl diester phosphodiesterase
I6J42_RS31655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J42_RS31685	COG0494	nUDIX hydrolase
I6J42_RS31695	COG0445	tRNA wobble uridine modification
I6J42_RS31715	COG2223	nitrite transmembrane transporter activity
I6J42_RS31720	COG1940	carbohydrate kinase activity
I6J42_RS31755	COG0702	epimerase
I6J42_RS31770	COG1349	DNA-binding transcription factor activity
I6J42_RS31780	COG0464	growth
I6J42_RS31815	COG5002	protein histidine kinase activity
I6J42_RS31955	COG1132	(ABC) transporter
I6J42_RS31960	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS31965	COG0328	RNA-DNA hybrid ribonuclease activity
I6J42_RS32020	COG1879	ABC-type sugar transport system periplasmic component
I6J42_RS32025	COG1129	ABC transporter
I6J42_RS32035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J42_RS32040	COG1609	Transcriptional regulator
I6J42_RS32045	COG0366	Alpha amylase catalytic
I6J42_RS32045	COG1874	Beta-galactosidase
I6J42_RS32080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32090	COG1120	ATPase activity
I6J42_RS32120	COG1295	ribonuclease BN
I6J42_RS32120	COG1959	2 iron, 2 sulfur cluster binding
I6J42_RS32175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J42_RS32200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32205	COG1120	ATPase activity
I6J42_RS32225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J42_RS32240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS32245	COG3246	L-lysine catabolic process to acetate
I6J42_RS32250	COG1309	transcriptional regulator
I6J42_RS32255	COG1191	sigma factor activity
I6J42_RS32285	COG0488	(ABC) transporter
I6J42_RS32300	COG1461	Dihydroxyacetone kinase
I6J42_RS32305	COG2376	Dihydroxyacetone kinase
I6J42_RS32325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J42_RS32340	COG4221	oxidoreductase activity
I6J42_RS32415	COG1295	ribonuclease BN
I6J42_RS32490	COG0587	DNA-directed DNA polymerase activity
I6J42_RS32500	COG1131	(ABC) transporter
I6J42_RS32505	COG3559	Exporter of polyketide antibiotics
I6J42_RS32535	COG0745	RESPONSE REGULATOR receiver
I6J42_RS32540	COG5002	protein histidine kinase activity
I6J42_RS32555	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J42_RS32560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32570	COG1120	ATPase activity
I6J42_RS32575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J42_RS32590	COG1132	(ABC) transporter
I6J42_RS32595	COG2382	esterase
I6J42_RS32615	COG0148	phosphopyruvate hydratase activity
I6J42_RS32635	COG3845	ABC transporter
I6J42_RS32670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J42_RS32690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J42_RS32695	COG3433	isochorismatase activity
I6J42_RS32695	COG1535	isochorismatase
I6J42_RS32700	COG1535	isochorismatase
I6J42_RS32700	COG3433	isochorismatase activity
I6J42_RS32705	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J42_RS32710	COG1169	isochorismate synthase
I6J42_RS32715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J42_RS32720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J42_RS32730	COG0477	Major facilitator Superfamily
I6J42_RS32740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS32750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J42_RS32755	COG1120	ATPase activity
I6J42_RS32790	COG2365	Tyrosine phosphatase family
I6J42_RS32835	COG2080	2 iron, 2 sulfur cluster binding
I6J42_RS32840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J42_RS32845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J42_RS32860	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J42_RS32865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J42_RS32875	COG2066	Belongs to the glutaminase family
I6J42_RS32875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6J42_RS32880	COG2356	endonuclease I
I6J42_RS32895	COG2813	Specifically methylates the guanine in position
I6J42_RS32900	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS32915	COG0789	Transcriptional regulator
I6J42_RS32920	COG0659	secondary active sulfate transmembrane transporter activity
I6J42_RS32925	COG0515	serine threonine protein kinase
I6J42_RS32935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J42_RS32940	COG2070	2-Nitropropane dioxygenase
I6J42_RS32970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J42_RS32985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J42_RS32990	COG1132	(ABC) transporter
I6J42_RS33010	COG1024	Enoyl-CoA hydratase
I6J42_RS33060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J42_RS33065	COG0254	rRNA binding
I6J42_RS33090	COG2318	DinB family
I6J42_RS33120	COG0596	Alpha beta hydrolase
I6J42_RS33155	COG1349	DNA-binding transcription factor activity
I6J42_RS33210	COG2318	DinB family
I6J42_RS33225	COG0642	Histidine kinase
I6J42_RS33240	COG0702	epimerase
I6J42_RS33255	COG1064	alcohol dehydrogenase
I6J42_RS33260	COG0640	Transcriptional regulator
I6J42_RS33265	COG1902	pentaerythritol trinitrate reductase activity
I6J42_RS33290	COG0789	Transcriptional regulator
I6J42_RS33300	COG1764	response to oxidative stress
I6J42_RS33305	COG1846	Transcriptional regulator
I6J42_RS33315	COG0477	Major facilitator Superfamily
I6J42_RS33325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J42_RS33360	COG5297	Belongs to the glycosyl hydrolase family 6
I6J42_RS33370	COG4941	Belongs to the sigma-70 factor family
I6J42_RS33415	COG3848	Pyruvate phosphate dikinase
I6J42_RS33415	COG0574	Belongs to the PEP-utilizing enzyme family
I6J42_RS33430	COG0590	tRNA wobble adenosine to inosine editing
I6J42_RS33445	COG0583	DNA-binding transcription factor activity
I6J42_RS33465	COG2197	response regulator
I6J42_RS33510	COG1132	(ABC) transporter
I6J42_RS33895	COG4264	IucA IucC family
I6J42_RS33905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J42_RS33930	COG0720	synthase
I6J42_RS33945	COG0302	gtp cyclohydrolase
I6J42_RS33960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J42_RS33990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J42_RS33995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J42_RS34030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J42_RS34040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J42_RS34060	COG1960	acyl-CoA dehydrogenase activity
I6J42_RS34090	COG1132	(ABC) transporter
I6J42_RS34095	COG2226	methyltransferase
I6J42_RS34155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J42_RS34160	COG1518	maintenance of DNA repeat elements
I6J42_RS34215	COG1725	Transcriptional regulator
I6J42_RS34280	COG1674	ftsk spoiiie
I6J42_RS34285	COG4974	Belongs to the 'phage' integrase family
I6J42_RS34400	COG1192	Involved in chromosome partitioning
I6J42_RS34440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J42_RS34455	COG0587	DNA-directed DNA polymerase activity
I6J42_RS34485	COG0492	ferredoxin-NADP+ reductase activity
I6J42_RS34490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J42_RS34500	COG0798	PFAM Bile acid sodium symporter
I6J42_RS34510	COG2072	flavoprotein involved in K transport
I6J42_RS34535	COG0640	Transcriptional regulator
I6J42_RS34560	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J42_RS34625	COG3328	transposase activity