locus-tag	class	description
I6J43_RS00125	COG1132	(ABC) transporter
I6J43_RS00165	COG2197	response regulator
I6J43_RS00185	COG0583	DNA-binding transcription factor activity
I6J43_RS00200	COG0590	tRNA wobble adenosine to inosine editing
I6J43_RS00215	COG3848	Pyruvate phosphate dikinase
I6J43_RS00215	COG0574	Belongs to the PEP-utilizing enzyme family
I6J43_RS00260	COG4941	Belongs to the sigma-70 factor family
I6J43_RS00270	COG5297	Belongs to the glycosyl hydrolase family 6
I6J43_RS00305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J43_RS00315	COG0477	Major facilitator Superfamily
I6J43_RS00325	COG1846	Transcriptional regulator
I6J43_RS00330	COG1764	response to oxidative stress
I6J43_RS00340	COG0789	Transcriptional regulator
I6J43_RS00365	COG1902	pentaerythritol trinitrate reductase activity
I6J43_RS00370	COG0640	Transcriptional regulator
I6J43_RS00375	COG1064	alcohol dehydrogenase
I6J43_RS00390	COG0702	epimerase
I6J43_RS00405	COG0642	Histidine kinase
I6J43_RS00420	COG2318	DinB family
I6J43_RS00475	COG1349	DNA-binding transcription factor activity
I6J43_RS00510	COG0596	Alpha beta hydrolase
I6J43_RS00540	COG2318	DinB family
I6J43_RS00565	COG0254	rRNA binding
I6J43_RS00570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J43_RS00620	COG1024	Enoyl-CoA hydratase
I6J43_RS00640	COG1132	(ABC) transporter
I6J43_RS00645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J43_RS00660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J43_RS00690	COG2070	2-Nitropropane dioxygenase
I6J43_RS00695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J43_RS00705	COG0515	serine threonine protein kinase
I6J43_RS00710	COG0659	secondary active sulfate transmembrane transporter activity
I6J43_RS00715	COG0789	Transcriptional regulator
I6J43_RS00730	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS00735	COG2813	Specifically methylates the guanine in position
I6J43_RS00750	COG2356	endonuclease I
I6J43_RS00755	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6J43_RS00755	COG2066	Belongs to the glutaminase family
I6J43_RS00765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J43_RS00770	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J43_RS00785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J43_RS00790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J43_RS00795	COG2080	2 iron, 2 sulfur cluster binding
I6J43_RS00840	COG2365	Tyrosine phosphatase family
I6J43_RS00875	COG1120	ATPase activity
I6J43_RS00880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J43_RS00890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS00900	COG0477	Major facilitator Superfamily
I6J43_RS00910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS00920	COG1169	isochorismate synthase
I6J43_RS00925	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J43_RS00930	COG3433	isochorismatase activity
I6J43_RS00930	COG1535	isochorismatase
I6J43_RS00935	COG3433	isochorismatase activity
I6J43_RS00935	COG1535	isochorismatase
I6J43_RS00940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J43_RS00960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J43_RS00995	COG3845	ABC transporter
I6J43_RS01015	COG0148	phosphopyruvate hydratase activity
I6J43_RS01035	COG2382	esterase
I6J43_RS01040	COG1132	(ABC) transporter
I6J43_RS01055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J43_RS01060	COG1120	ATPase activity
I6J43_RS01065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS01075	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J43_RS01090	COG5002	protein histidine kinase activity
I6J43_RS01095	COG0745	RESPONSE REGULATOR receiver
I6J43_RS01125	COG3559	Exporter of polyketide antibiotics
I6J43_RS01130	COG1131	(ABC) transporter
I6J43_RS01140	COG0587	DNA-directed DNA polymerase activity
I6J43_RS01215	COG1295	ribonuclease BN
I6J43_RS01290	COG4221	oxidoreductase activity
I6J43_RS01305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS01325	COG2376	Dihydroxyacetone kinase
I6J43_RS01330	COG1461	Dihydroxyacetone kinase
I6J43_RS01345	COG0488	(ABC) transporter
I6J43_RS01375	COG1191	sigma factor activity
I6J43_RS01380	COG1309	transcriptional regulator
I6J43_RS01385	COG3246	L-lysine catabolic process to acetate
I6J43_RS01390	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS01405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J43_RS01425	COG1120	ATPase activity
I6J43_RS01430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS01455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS01510	COG1959	2 iron, 2 sulfur cluster binding
I6J43_RS01510	COG1295	ribonuclease BN
I6J43_RS01540	COG1120	ATPase activity
I6J43_RS01545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS01550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS01585	COG1874	Beta-galactosidase
I6J43_RS01585	COG0366	Alpha amylase catalytic
I6J43_RS01590	COG1609	Transcriptional regulator
I6J43_RS01595	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J43_RS01605	COG1129	ABC transporter
I6J43_RS01610	COG1879	ABC-type sugar transport system periplasmic component
I6J43_RS01665	COG0328	RNA-DNA hybrid ribonuclease activity
I6J43_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS01675	COG1132	(ABC) transporter
I6J43_RS01815	COG5002	protein histidine kinase activity
I6J43_RS01850	COG0464	growth
I6J43_RS01860	COG1349	DNA-binding transcription factor activity
I6J43_RS01875	COG0702	epimerase
I6J43_RS01910	COG1940	carbohydrate kinase activity
I6J43_RS01915	COG2223	nitrite transmembrane transporter activity
I6J43_RS01935	COG0445	tRNA wobble uridine modification
I6J43_RS01945	COG0494	nUDIX hydrolase
I6J43_RS01975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J43_RS02025	COG0584	glycerophosphoryl diester phosphodiesterase
I6J43_RS02045	COG0671	phosphoesterase, PA-phosphatase related
I6J43_RS02090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J43_RS02105	COG2706	6-phosphogluconolactonase activity
I6J43_RS02150	COG3961	Belongs to the TPP enzyme family
I6J43_RS02155	COG2197	response regulator
I6J43_RS02170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J43_RS02175	COG3483	tryptophan 2,3-dioxygenase activity
I6J43_RS02180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J43_RS02200	COG0107	imidazoleglycerol-phosphate synthase activity
I6J43_RS02255	COG0515	serine threonine protein kinase
I6J43_RS02255	COG2815	serine threonine protein kinase
I6J43_RS02260	COG0667	Aldo Keto reductase
I6J43_RS02285	COG1253	flavin adenine dinucleotide binding
I6J43_RS02320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J43_RS02325	COG0531	amino acid
I6J43_RS02335	COG0174	glutamine synthetase
I6J43_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS02375	COG4981	capsule polysaccharide biosynthetic process
I6J43_RS02395	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J43_RS02405	COG1802	Transcriptional regulator
I6J43_RS02410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J43_RS02415	COG0402	S-adenosylhomocysteine deaminase activity
I6J43_RS02435	COG0542	response to heat
I6J43_RS02490	COG1335	isochorismatase
I6J43_RS02505	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J43_RS02535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J43_RS02540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J43_RS02545	COG2080	2 iron, 2 sulfur cluster binding
I6J43_RS02575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J43_RS02585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS02640	COG1891	lyase activity
I6J43_RS02655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J43_RS02710	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J43_RS02735	COG1309	transcriptional regulator
I6J43_RS02740	COG1982	Orn Lys Arg decarboxylase major
I6J43_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS02760	COG1309	transcriptional regulator
I6J43_RS02815	COG2814	Major facilitator Superfamily
I6J43_RS02840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J43_RS02885	COG1959	2 iron, 2 sulfur cluster binding
I6J43_RS02910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J43_RS02920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J43_RS02925	COG1116	anion transmembrane transporter activity
I6J43_RS02940	COG2072	flavoprotein involved in K transport
I6J43_RS02945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J43_RS02955	COG1132	(ABC) transporter
I6J43_RS02960	COG1846	Transcriptional regulator
I6J43_RS02965	COG0277	FAD linked oxidase domain protein
I6J43_RS02970	COG0673	inositol 2-dehydrogenase activity
I6J43_RS02975	COG1132	(ABC) transporter
I6J43_RS02980	COG1132	(ABC) transporter
I6J43_RS03000	COG1793	dna ligase
I6J43_RS03015	COG1946	Acyl-CoA thioesterase
I6J43_RS03030	COG0386	Belongs to the glutathione peroxidase family
I6J43_RS03035	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS03045	COG0242	peptide deformylase activity
I6J43_RS03055	COG3442	glutamine amidotransferase
I6J43_RS03060	COG0205	6-phosphofructokinase activity
I6J43_RS03075	COG0204	Acyl-transferase
I6J43_RS03090	COG0829	nickel cation binding
I6J43_RS03095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J43_RS03105	COG0804	urea catabolic process
I6J43_RS03110	COG0832	Belongs to the urease beta subunit family
I6J43_RS03115	COG0831	urea catabolic process
I6J43_RS03120	COG1309	transcriptional regulator
I6J43_RS03135	COG0740	serine-type endopeptidase activity
I6J43_RS03150	COG1280	lysine exporter protein (LysE YggA)
I6J43_RS03155	COG0583	DNA-binding transcription factor activity
I6J43_RS03175	COG0156	8-amino-7-oxononanoate synthase activity
I6J43_RS03180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J43_RS03185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J43_RS03190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J43_RS03235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J43_RS03245	COG1940	carbohydrate kinase activity
I6J43_RS03250	COG2188	Transcriptional regulator
I6J43_RS03255	COG1595	DNA-templated transcription, initiation
I6J43_RS03270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J43_RS03295	COG0626	cystathionine gamma-synthase activity
I6J43_RS03315	COG0419	ATPase involved in DNA repair
I6J43_RS03320	COG0420	3'-5' exonuclease activity
I6J43_RS03325	COG1739	Uncharacterized protein family UPF0029
I6J43_RS03330	COG1832	CoA-binding protein
I6J43_RS03370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J43_RS03390	COG1968	undecaprenyl-diphosphatase activity
I6J43_RS03420	COG2226	methyltransferase
I6J43_RS03485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J43_RS03545	COG0069	glutamate synthase activity
I6J43_RS03600	COG0477	Major facilitator Superfamily
I6J43_RS03615	COG0784	Response regulator, receiver
I6J43_RS03620	COG4251	negative regulation of phosphorylation
I6J43_RS03625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J43_RS03635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J43_RS03645	COG1215	transferase activity, transferring glycosyl groups
I6J43_RS03665	COG3800	Transcriptional regulator
I6J43_RS03665	COG1396	sequence-specific DNA binding
I6J43_RS03765	COG1695	Transcriptional regulator
I6J43_RS03790	COG1595	DNA-templated transcription, initiation
I6J43_RS03845	COG0384	phenazine biosynthesis protein PhzF
I6J43_RS03875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J43_RS03875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J43_RS03885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J43_RS03905	COG1716	ATPase activity
I6J43_RS03925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J43_RS03955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J43_RS03965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J43_RS03980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6J43_RS04010	COG2018	Roadblock/LC7 domain
I6J43_RS04075	COG2364	Membrane
I6J43_RS04085	COG2270	Major facilitator Superfamily
I6J43_RS04100	COG1216	Glycosyl transferase, family 2
I6J43_RS04120	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS04125	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS04135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J43_RS04180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J43_RS04185	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J43_RS04190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J43_RS04195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J43_RS04195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J43_RS04200	COG3201	nicotinamide mononucleotide transporter
I6J43_RS04225	COG0738	Major facilitator superfamily
I6J43_RS04230	COG2233	PERMEase
I6J43_RS04240	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS04255	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J43_RS04275	COG0142	geranyltranstransferase activity
I6J43_RS04290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J43_RS04300	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS04315	COG2390	Transcriptional regulator
I6J43_RS04320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J43_RS04330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J43_RS04345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J43_RS04355	COG1758	RNA polymerase activity
I6J43_RS04370	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J43_RS04375	COG0167	dihydroorotate dehydrogenase activity
I6J43_RS04380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J43_RS04385	COG0505	Belongs to the CarA family
I6J43_RS04395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J43_RS04400	COG0540	Belongs to the ATCase OTCase family
I6J43_RS04405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J43_RS04415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J43_RS04420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J43_RS04425	COG0006	proline dipeptidase activity
I6J43_RS04435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J43_RS04440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J43_RS04445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J43_RS04450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J43_RS04460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J43_RS04465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J43_RS04485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J43_RS04505	COG0124	histidyl-tRNA synthetase
I6J43_RS04520	COG1196	nuclear chromosome segregation
I6J43_RS04540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J43_RS04545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J43_RS04550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J43_RS04555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J43_RS04565	COG2255	four-way junction helicase activity
I6J43_RS04570	COG0632	four-way junction helicase activity
I6J43_RS04575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J43_RS04580	COG0217	transcriptional regulatory protein
I6J43_RS04585	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J43_RS04590	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J43_RS04600	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS04605	COG1560	Kdo2-lipid A biosynthetic process
I6J43_RS04610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J43_RS04630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J43_RS04645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J43_RS04705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J43_RS04760	COG1648	precorrin-2 dehydrogenase activity
I6J43_RS04760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J43_RS04765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J43_RS04780	COG1464	Belongs to the NlpA lipoprotein family
I6J43_RS04785	COG2011	ABC-type metal ion transport system permease component
I6J43_RS04825	COG0477	Major facilitator Superfamily
I6J43_RS04835	COG3973	AAA domain
I6J43_RS04845	COG0165	Argininosuccinate lyase
I6J43_RS04850	COG0137	argininosuccinate synthase activity
I6J43_RS04865	COG1438	arginine binding
I6J43_RS04870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J43_RS04875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J43_RS04880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J43_RS04885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J43_RS04945	COG0697	spore germination
I6J43_RS04955	COG1649	PFAM Uncharacterised BCR, COG1649
I6J43_RS04980	COG0072	phenylalanine-tRNA ligase activity
I6J43_RS04980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J43_RS04985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J43_RS04990	COG5002	protein histidine kinase activity
I6J43_RS04995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J43_RS05000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J43_RS05005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J43_RS05010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J43_RS05020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J43_RS05075	COG0517	IMP dehydrogenase activity
I6J43_RS05075	COG4175	Glycine betaine
I6J43_RS05080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J43_RS05110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J43_RS05115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J43_RS05155	COG0805	protein transport
I6J43_RS05160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J43_RS05180	COG2378	regulation of single-species biofilm formation
I6J43_RS05190	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J43_RS05195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J43_RS05205	COG1609	Transcriptional regulator
I6J43_RS05210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J43_RS05215	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J43_RS05225	COG4122	O-methyltransferase activity
I6J43_RS05230	COG1222	aaa ATPase
I6J43_RS05250	COG1994	Peptidase M50
I6J43_RS05250	COG0517	IMP dehydrogenase activity
I6J43_RS05260	COG2197	response regulator
I6J43_RS05265	COG4166	transmembrane transport
I6J43_RS05270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS05275	COG0646	methionine synthase
I6J43_RS05275	COG1410	methionine synthase
I6J43_RS05280	COG1414	Transcriptional regulator
I6J43_RS05285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J43_RS05290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J43_RS05295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J43_RS05300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS05310	COG0215	cysteine-tRNA ligase activity
I6J43_RS05330	COG0598	Magnesium transport protein CorA
I6J43_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS05345	COG0667	Aldo Keto reductase
I6J43_RS05375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J43_RS05385	COG0564	pseudouridine synthase activity
I6J43_RS05400	COG2186	Transcriptional regulator
I6J43_RS05405	COG3265	gluconokinase activity
I6J43_RS05435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J43_RS05440	COG2149	membrane
I6J43_RS05460	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS05465	COG2234	aminopeptidase activity
I6J43_RS05465	COG4935	Belongs to the peptidase S8 family
I6J43_RS05475	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS05485	COG3876	Protein conserved in bacteria
I6J43_RS05520	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS05535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J43_RS05545	COG2318	DinB family
I6J43_RS05555	COG2851	Citrate transporter
I6J43_RS05560	COG1309	transcriptional regulator
I6J43_RS05580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6J43_RS05585	COG2188	Transcriptional regulator
I6J43_RS05595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J43_RS05605	COG2755	lipolytic protein G-D-S-L family
I6J43_RS05615	COG1725	Transcriptional regulator
I6J43_RS05630	COG0346	lactoylglutathione lyase activity
I6J43_RS05650	COG4565	transcriptional regulatory protein
I6J43_RS05685	COG4585	Histidine kinase
I6J43_RS05690	COG2197	response regulator
I6J43_RS05710	COG0641	radical SAM
I6J43_RS05745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS05750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS05755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS05760	COG1126	abc transporter atp-binding protein
I6J43_RS05775	COG0765	amino acid transport
I6J43_RS05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS05790	COG1799	cell septum assembly
I6J43_RS05795	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS05800	COG0477	Major facilitator Superfamily
I6J43_RS05805	COG0671	phosphoesterase, PA-phosphatase related
I6J43_RS05820	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS05835	COG1160	GTP binding
I6J43_RS05845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J43_RS05870	COG0494	nUDIX hydrolase
I6J43_RS05885	COG1187	pseudouridine synthase activity
I6J43_RS05890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J43_RS05895	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J43_RS05910	COG0686	Belongs to the AlaDH PNT family
I6J43_RS05920	COG0494	nUDIX hydrolase
I6J43_RS05925	COG0504	CTP synthase activity
I6J43_RS05930	COG3387	PFAM Glycoside hydrolase 15-related
I6J43_RS05955	COG0497	DNA recombination
I6J43_RS05960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J43_RS05980	COG1120	ATPase activity
I6J43_RS05985	COG0647	UMP catabolic process
I6J43_RS06020	COG2094	Belongs to the DNA glycosylase MPG family
I6J43_RS06030	COG1881	PFAM PEBP family protein
I6J43_RS06055	COG1119	ATPase activity
I6J43_RS06065	COG2197	response regulator
I6J43_RS06070	COG4585	Histidine kinase
I6J43_RS06080	COG1716	ATPase activity
I6J43_RS06080	COG1131	(ABC) transporter
I6J43_RS06080	COG0842	Transport permease protein
I6J43_RS06085	COG0560	Phosphoserine phosphatase
I6J43_RS06085	COG3830	Belongs to the UPF0237 family
I6J43_RS06115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J43_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS06145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J43_RS06150	COG2261	transglycosylase associated protein
I6J43_RS06165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J43_RS06170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J43_RS06210	COG3387	PFAM Glycoside hydrolase 15-related
I6J43_RS06250	COG1024	Enoyl-CoA hydratase
I6J43_RS06260	COG0488	(ABC) transporter
I6J43_RS06285	COG0235	Class ii aldolase
I6J43_RS06300	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J43_RS06305	COG1492	cobalamin metabolic process
I6J43_RS06320	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J43_RS06345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J43_RS06375	COG1902	pentaerythritol trinitrate reductase activity
I6J43_RS06425	COG4585	Histidine kinase
I6J43_RS06430	COG2197	response regulator
I6J43_RS06435	COG0768	penicillin binding
I6J43_RS06475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J43_RS06480	COG2171	N-acyltransferase activity
I6J43_RS06485	COG3226	Transcriptional regulator
I6J43_RS06500	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J43_RS06505	COG0822	iron-sulfur transferase activity
I6J43_RS06510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J43_RS06515	COG0396	ATPase activity
I6J43_RS06525	COG0719	Fe-S assembly protein
I6J43_RS06560	COG0109	protoheme IX farnesyltransferase activity
I6J43_RS06570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J43_RS06585	COG0363	glucosamine-6-phosphate deaminase activity
I6J43_RS06595	COG4195	phage-related replication protein
I6J43_RS06610	COG0166	Belongs to the GPI family
I6J43_RS06620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J43_RS06625	COG0149	triose-phosphate isomerase activity
I6J43_RS06630	COG0126	phosphoglycerate kinase activity
I6J43_RS06635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J43_RS06640	COG1481	regulation of sporulation
I6J43_RS06645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J43_RS06650	COG1660	Displays ATPase and GTPase activities
I6J43_RS06655	COG0322	excinuclease ABC activity
I6J43_RS06680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J43_RS06710	COG0556	nucleotide-excision repair
I6J43_RS06720	COG0584	glycerophosphoryl diester phosphodiesterase
I6J43_RS06730	COG2814	Major facilitator Superfamily
I6J43_RS06740	COG2313	pseudouridylate synthase activity
I6J43_RS06760	COG0436	Aminotransferase
I6J43_RS06780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J43_RS06790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J43_RS06810	COG0237	dephospho-CoA kinase activity
I6J43_RS06835	COG1643	Atp-dependent helicase
I6J43_RS06870	COG2050	protein possibly involved in aromatic compounds catabolism
I6J43_RS06880	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J43_RS06925	COG0737	Belongs to the 5'-nucleotidase family
I6J43_RS06960	COG0287	Prephenate dehydrogenase
I6J43_RS06960	COG1605	Chorismate mutase
I6J43_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS07000	COG1024	Enoyl-CoA hydratase
I6J43_RS07025	COG1278	Cold shock
I6J43_RS07030	COG0183	Belongs to the thiolase family
I6J43_RS07035	COG1309	transcriptional regulator
I6J43_RS07045	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS07075	COG0705	Rhomboid family
I6J43_RS07085	COG0067	glutamate synthase
I6J43_RS07085	COG0069	glutamate synthase activity
I6J43_RS07085	COG0070	glutamate synthase
I6J43_RS07115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J43_RS07120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J43_RS07130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J43_RS07140	COG0159	tryptophan synthase activity
I6J43_RS07145	COG0133	tryptophan synthase activity
I6J43_RS07155	COG0134	indole-3-glycerol-phosphate synthase activity
I6J43_RS07175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J43_RS07180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J43_RS07200	COG0107	imidazoleglycerol-phosphate synthase activity
I6J43_RS07205	COG0251	oxidation-reduction process
I6J43_RS07210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J43_RS07215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J43_RS07225	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J43_RS07230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J43_RS07235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J43_RS07255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J43_RS07280	COG1432	Conserved Protein
I6J43_RS07290	COG0587	DNA-directed DNA polymerase activity
I6J43_RS07335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J43_RS07345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J43_RS07350	COG3599	regulation of cell shape
I6J43_RS07360	COG1799	cell septum assembly
I6J43_RS07365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J43_RS07385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J43_RS07395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J43_RS07400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J43_RS07410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J43_RS07415	COG0768	penicillin binding
I6J43_RS07425	COG0275	rRNA processing
I6J43_RS07435	COG0714	Associated with various cellular activities
I6J43_RS07455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J43_RS07465	COG1136	(ABC) transporter
I6J43_RS07465	COG0577	efflux transmembrane transporter activity
I6J43_RS07485	COG1233	COG1233 Phytoene dehydrogenase and related
I6J43_RS07500	COG0352	thiamine-phosphate diphosphorylase activity
I6J43_RS07520	COG2022	thiamine diphosphate biosynthetic process
I6J43_RS07520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J43_RS07530	COG2022	thiamine diphosphate biosynthetic process
I6J43_RS07535	COG0515	serine threonine protein kinase
I6J43_RS07535	COG2815	serine threonine protein kinase
I6J43_RS07540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J43_RS07545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J43_RS07550	COG2193	ferroxidase activity
I6J43_RS07560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J43_RS07575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J43_RS07580	COG2197	response regulator
I6J43_RS07610	COG1940	carbohydrate kinase activity
I6J43_RS07620	COG0003	Pfam Anion-transporting ATPase
I6J43_RS07635	COG1022	Amp-dependent synthetase and ligase
I6J43_RS07685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J43_RS07690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J43_RS07695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J43_RS07700	COG0723	plastoquinol--plastocyanin reductase activity
I6J43_RS07705	COG2010	Cytochrome c
I6J43_RS07710	COG1845	cytochrome c oxidase, subunit III
I6J43_RS07720	COG1376	ErfK ybiS ycfS ynhG family protein
I6J43_RS07730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J43_RS07735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J43_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J43_RS07765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J43_RS07775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J43_RS07780	COG2197	response regulator
I6J43_RS07785	COG4585	Histidine kinase
I6J43_RS07810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J43_RS07825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J43_RS07840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J43_RS07845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J43_RS07850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J43_RS07855	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J43_RS07865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J43_RS07885	COG1090	epimerase
I6J43_RS07905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J43_RS07930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J43_RS07935	COG3896	Chloramphenicol phosphotransferase-like protein
I6J43_RS07965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J43_RS07970	COG0673	inositol 2-dehydrogenase activity
I6J43_RS07990	COG0745	RESPONSE REGULATOR receiver
I6J43_RS07995	COG2409	Drug exporters of the RND superfamily
I6J43_RS08000	COG4585	Histidine kinase
I6J43_RS08005	COG2197	response regulator
I6J43_RS08065	COG0366	Alpha amylase catalytic
I6J43_RS08070	COG0395	ABC-type sugar transport system, permease component
I6J43_RS08080	COG2182	Extracellular solute-binding protein
I6J43_RS08085	COG1609	Transcriptional regulator
I6J43_RS08095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J43_RS08100	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J43_RS08105	COG0477	Major facilitator Superfamily
I6J43_RS08145	COG0494	nUDIX hydrolase
I6J43_RS08170	COG2188	Transcriptional regulator
I6J43_RS08205	COG0174	glutamine synthetase
I6J43_RS08220	COG2132	Multicopper oxidase
I6J43_RS08225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J43_RS08225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J43_RS08230	COG2814	Major facilitator Superfamily
I6J43_RS08245	COG0477	Major facilitator Superfamily
I6J43_RS08250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J43_RS08270	COG1994	Peptidase M50
I6J43_RS08330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS08335	COG1120	ATPase activity
I6J43_RS08355	COG1834	amidinotransferase
I6J43_RS08370	COG2814	Major facilitator Superfamily
I6J43_RS08380	COG3540	Alkaline phosphatase
I6J43_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS08395	COG0384	phenazine biosynthesis protein PhzF
I6J43_RS08435	COG2273	Hydrolase Family 16
I6J43_RS08460	COG3022	response to hydroperoxide
I6J43_RS08465	COG0800	Aldolase
I6J43_RS08480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J43_RS08485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J43_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS08510	COG2030	dehydratase
I6J43_RS08520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J43_RS08525	COG0183	Belongs to the thiolase family
I6J43_RS08530	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS08540	COG3340	Belongs to the peptidase S51 family
I6J43_RS08555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J43_RS08560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J43_RS08580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS08605	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS08610	COG1309	transcriptional regulator
I6J43_RS08665	COG3845	ABC transporter
I6J43_RS08680	COG0183	Belongs to the thiolase family
I6J43_RS08685	COG2124	cytochrome p450
I6J43_RS08730	COG2259	Doxx family
I6J43_RS08810	COG1358	cellular component organization or biogenesis
I6J43_RS08855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J43_RS08865	COG0477	Major facilitator Superfamily
I6J43_RS08870	COG1309	transcriptional regulator
I6J43_RS08885	COG4585	Histidine kinase
I6J43_RS08890	COG2197	response regulator
I6J43_RS08905	COG0667	Aldo Keto reductase
I6J43_RS08910	COG0789	Transcriptional regulator
I6J43_RS08920	COG2205	protein histidine kinase activity
I6J43_RS08925	COG0745	RESPONSE REGULATOR receiver
I6J43_RS08935	COG0667	Aldo Keto reductase
I6J43_RS08945	COG1929	Belongs to the glycerate kinase type-1 family
I6J43_RS09020	COG1674	ftsk spoiiie
I6J43_RS09025	COG1404	Belongs to the peptidase S8 family
I6J43_RS09080	COG2957	Belongs to the agmatine deiminase family
I6J43_RS09085	COG0456	acetyltransferase
I6J43_RS09095	COG1741	Belongs to the pirin family
I6J43_RS09140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J43_RS09145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS09150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS09175	COG1764	response to oxidative stress
I6J43_RS09180	COG2130	NADP-dependent
I6J43_RS09210	COG1522	sequence-specific DNA binding
I6J43_RS09220	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS09225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J43_RS09225	COG0825	malonyl-CoA metabolic process
I6J43_RS09230	COG0477	Major facilitator Superfamily
I6J43_RS09255	COG1070	Carbohydrate kinase
I6J43_RS09270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J43_RS09275	COG0358	DNA primase activity
I6J43_RS09285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J43_RS09295	COG2949	membrane
I6J43_RS09340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J43_RS09340	COG2146	nitrite reductase [NAD(P)H] activity
I6J43_RS09365	COG0574	Belongs to the PEP-utilizing enzyme family
I6J43_RS09365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J43_RS09370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS09375	COG3842	ATPase activity
I6J43_RS09395	COG2188	Transcriptional regulator
I6J43_RS09425	COG0477	Major facilitator Superfamily
I6J43_RS09430	COG2066	Belongs to the glutaminase family
I6J43_RS09445	COG1309	transcriptional regulator
I6J43_RS09575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J43_RS09590	COG0277	FAD linked oxidase domain protein
I6J43_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS09600	COG2124	cytochrome p450
I6J43_RS09635	COG0477	Major facilitator Superfamily
I6J43_RS09640	COG2345	Transcriptional regulator
I6J43_RS09665	COG0367	asparagine synthase
I6J43_RS09675	COG0662	Cupin 2, conserved barrel domain protein
I6J43_RS09680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS09685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS09710	COG3104	oligopeptide transport
I6J43_RS09720	COG0423	glycine-tRNA ligase activity
I6J43_RS09730	COG1121	(ABC) transporter
I6J43_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J43_RS09745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J43_RS09750	COG1381	Involved in DNA repair and RecF pathway recombination
I6J43_RS09760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J43_RS09775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J43_RS09790	COG2315	Protein conserved in bacteria
I6J43_RS09800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J43_RS09810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J43_RS09810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J43_RS09820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J43_RS09825	COG1234	tRNA 3'-trailer cleavage
I6J43_RS09830	COG0537	adenosine 5'-monophosphoramidase activity
I6J43_RS09845	COG0484	heat shock protein binding
I6J43_RS09850	COG1420	regulation of RNA biosynthetic process
I6J43_RS09890	COG0481	GTPase activity
I6J43_RS09895	COG0268	Binds directly to 16S ribosomal RNA
I6J43_RS09930	COG0210	DNA helicase
I6J43_RS09935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J43_RS09965	COG1555	photosystem II stabilization
I6J43_RS09970	COG1307	EDD domain protein, DegV family
I6J43_RS09980	COG0495	leucyl-tRNA aminoacylation
I6J43_RS10000	COG0588	phosphoglycerate mutase activity
I6J43_RS10005	COG0799	negative regulation of ribosome biogenesis
I6J43_RS10015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J43_RS10030	COG0501	Belongs to the peptidase M48B family
I6J43_RS10045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J43_RS10055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J43_RS10080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J43_RS10085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J43_RS10090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J43_RS10095	COG1530	ribonuclease E activity
I6J43_RS10120	COG0772	Belongs to the SEDS family
I6J43_RS10125	COG0768	penicillin binding
I6J43_RS10140	COG1077	Cell shape determining protein MreB Mrl
I6J43_RS10145	COG0105	UTP biosynthetic process
I6J43_RS10155	COG0285	dihydrofolate synthase activity
I6J43_RS10160	COG0525	valine-tRNA ligase activity
I6J43_RS10170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J43_RS10175	COG0740	serine-type endopeptidase activity
I6J43_RS10180	COG0740	serine-type endopeptidase activity
I6J43_RS10185	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J43_RS10205	COG3594	Acyltransferase
I6J43_RS10215	COG0475	glutathione-regulated potassium exporter activity
I6J43_RS10235	COG1113	amino acid transport
I6J43_RS10245	COG1268	BioY protein
I6J43_RS10250	COG1113	amino acid transport
I6J43_RS10260	COG0584	glycerophosphoryl diester phosphodiesterase
I6J43_RS10265	COG0783	Belongs to the Dps family
I6J43_RS10275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J43_RS10280	COG0640	Transcriptional regulator
I6J43_RS10295	COG0110	maltose O-acetyltransferase activity
I6J43_RS10300	COG1404	Belongs to the peptidase S8 family
I6J43_RS10320	COG2252	PERMEase
I6J43_RS10330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J43_RS10355	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J43_RS10380	COG4266	Belongs to the allantoicase family
I6J43_RS10385	COG0583	DNA-binding transcription factor activity
I6J43_RS10405	COG3291	Pkd domain containing protein
I6J43_RS10405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J43_RS10415	COG0668	transmembrane transport
I6J43_RS10435	COG1940	carbohydrate kinase activity
I6J43_RS10445	COG1175	transmembrane transport
I6J43_RS10450	COG0395	ABC-type sugar transport system, permease component
I6J43_RS10455	COG1486	melibiose metabolic process
I6J43_RS10470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS10500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J43_RS10520	COG1136	(ABC) transporter
I6J43_RS10520	COG0577	efflux transmembrane transporter activity
I6J43_RS10545	COG0629	single-stranded DNA binding
I6J43_RS10580	COG1674	ftsk spoiiie
I6J43_RS10680	COG2197	response regulator
I6J43_RS10685	COG4585	Histidine kinase
I6J43_RS10705	COG3962	Belongs to the TPP enzyme family
I6J43_RS10710	COG3718	enzyme involved in inositol metabolism
I6J43_RS10720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J43_RS10730	COG2318	DinB family
I6J43_RS10770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J43_RS10795	COG0596	Alpha beta hydrolase
I6J43_RS10845	COG0673	inositol 2-dehydrogenase activity
I6J43_RS10850	COG1609	Transcriptional regulator
I6J43_RS10885	COG0515	serine threonine protein kinase
I6J43_RS10920	COG1404	Belongs to the peptidase S8 family
I6J43_RS10945	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J43_RS10960	COG0477	Major facilitator Superfamily
I6J43_RS10990	COG0028	Belongs to the TPP enzyme family
I6J43_RS11025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J43_RS11050	COG1946	Acyl-CoA thioesterase
I6J43_RS11080	COG1309	transcriptional regulator
I6J43_RS11085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J43_RS11100	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS11120	COG0076	glutamate decarboxylase activity
I6J43_RS11125	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J43_RS11150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J43_RS11160	COG4977	sequence-specific DNA binding
I6J43_RS11195	COG0395	ABC-type sugar transport system, permease component
I6J43_RS11210	COG2985	domain, Protein
I6J43_RS11225	COG0745	RESPONSE REGULATOR receiver
I6J43_RS11300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS11310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J43_RS11320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS11325	COG0765	amino acid transport
I6J43_RS11330	COG0765	amino acid transport
I6J43_RS11335	COG1126	abc transporter atp-binding protein
I6J43_RS11340	COG1414	Transcriptional regulator
I6J43_RS11350	COG3397	chitin binding
I6J43_RS11415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J43_RS11420	COG2188	Transcriptional regulator
I6J43_RS11430	COG1940	carbohydrate kinase activity
I6J43_RS11435	COG0673	inositol 2-dehydrogenase activity
I6J43_RS11440	COG4702	Belongs to the UPF0303 family
I6J43_RS11445	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J43_RS11450	COG0706	membrane insertase activity
I6J43_RS11450	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
I6J43_RS11460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J43_RS11470	COG3764	Sortase (surface protein transpeptidase)
I6J43_RS11510	COG3655	Transcriptional regulator
I6J43_RS11540	COG3135	benzoate transporter
I6J43_RS11545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J43_RS11560	COG2175	clavaminate synthase activity
I6J43_RS11570	COG0596	Alpha beta hydrolase
I6J43_RS11580	COG2733	membrane
I6J43_RS11595	COG4555	ABC transporter
I6J43_RS11610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J43_RS11635	COG0477	Major facilitator Superfamily
I6J43_RS11655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J43_RS11665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J43_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J43_RS11675	COG1263	PTS System
I6J43_RS11680	COG1263	PTS System
I6J43_RS11690	COG1234	tRNA 3'-trailer cleavage
I6J43_RS11715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS11730	COG1113	amino acid transport
I6J43_RS11740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J43_RS11750	COG1335	isochorismatase
I6J43_RS11785	COG0277	FAD linked oxidase domain protein
I6J43_RS11795	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J43_RS11805	COG1174	glycine betaine transport
I6J43_RS11810	COG1125	glycine betaine transport
I6J43_RS11810	COG0517	IMP dehydrogenase activity
I6J43_RS11815	COG1174	glycine betaine transport
I6J43_RS11820	COG1732	Glycine betaine
I6J43_RS11840	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J43_RS11875	COG3654	unkown
I6J43_RS11935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J43_RS11940	COG0395	ABC-type sugar transport system, permease component
I6J43_RS11950	COG2182	Extracellular solute-binding protein
I6J43_RS11960	COG1678	Uncharacterized ACR, COG1678
I6J43_RS11965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J43_RS11970	COG0776	regulation of translation
I6J43_RS11980	COG3973	AAA domain
I6J43_RS11980	COG3973	AAA domain
I6J43_RS12005	COG2223	nitrite transmembrane transporter activity
I6J43_RS12010	COG0583	DNA-binding transcription factor activity
I6J43_RS12055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J43_RS12060	COG0793	Belongs to the peptidase S41A family
I6J43_RS12065	COG2177	Part of the ABC transporter FtsEX involved in
I6J43_RS12070	COG2884	Cell division ATP-binding protein ftsE
I6J43_RS12085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J43_RS12090	COG0515	serine threonine protein kinase
I6J43_RS12095	COG0515	serine threonine protein kinase
I6J43_RS12105	COG1653	transport
I6J43_RS12110	COG1175	transmembrane transport
I6J43_RS12115	COG0395	ABC-type sugar transport system, permease component
I6J43_RS12120	COG1216	Glycosyl transferase, family 2
I6J43_RS12120	COG1442	glycosyl transferase family 8
I6J43_RS12125	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS12130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J43_RS12135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J43_RS12140	COG4122	O-methyltransferase activity
I6J43_RS12145	COG2226	methyltransferase
I6J43_RS12145	COG1073	alpha beta
I6J43_RS12150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J43_RS12155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J43_RS12165	COG1309	transcriptional regulator
I6J43_RS12175	COG1134	teichoic acid transport
I6J43_RS12180	COG2902	Dehydrogenase
I6J43_RS12200	COG0653	protein targeting
I6J43_RS12215	COG2197	response regulator
I6J43_RS12220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J43_RS12230	COG0823	Involved in the tonB-independent uptake of proteins
I6J43_RS12235	COG5002	protein histidine kinase activity
I6J43_RS12235	COG5000	phosphorelay sensor kinase activity
I6J43_RS12240	COG0745	RESPONSE REGULATOR receiver
I6J43_RS12260	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J43_RS12265	COG2188	Transcriptional regulator
I6J43_RS12325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J43_RS12345	COG0714	Associated with various cellular activities
I6J43_RS12385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J43_RS12405	COG2835	tetraacyldisaccharide 4'-kinase activity
I6J43_RS12410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J43_RS12445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J43_RS12450	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J43_RS12450	COG0778	Nitroreductase
I6J43_RS12455	COG0531	amino acid
I6J43_RS12480	COG1316	TRANSCRIPTIONal
I6J43_RS12485	COG1316	TRANSCRIPTIONal
I6J43_RS12490	COG1316	TRANSCRIPTIONal
I6J43_RS12495	COG1316	TRANSCRIPTIONal
I6J43_RS12505	COG1316	TRANSCRIPTIONal
I6J43_RS12575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J43_RS12605	COG2205	protein histidine kinase activity
I6J43_RS12610	COG0745	RESPONSE REGULATOR receiver
I6J43_RS12615	COG3104	oligopeptide transport
I6J43_RS12645	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS12650	COG1191	sigma factor activity
I6J43_RS12655	COG1228	amidohydrolase
I6J43_RS12665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J43_RS12670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J43_RS12675	COG0531	amino acid
I6J43_RS12715	COG2755	lipolytic protein G-D-S-L family
I6J43_RS12720	COG0183	Belongs to the thiolase family
I6J43_RS12745	COG1136	(ABC) transporter
I6J43_RS12750	COG1136	(ABC) transporter
I6J43_RS12750	COG0577	efflux transmembrane transporter activity
I6J43_RS12755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J43_RS12760	COG1252	NADH dehydrogenase
I6J43_RS12780	COG0148	phosphopyruvate hydratase activity
I6J43_RS12790	COG1652	LysM domain
I6J43_RS12815	COG2815	serine threonine protein kinase
I6J43_RS12815	COG0515	serine threonine protein kinase
I6J43_RS12835	COG1335	isochorismatase
I6J43_RS12880	COG1473	amidohydrolase
I6J43_RS12935	COG3903	Transcriptional regulator
I6J43_RS12935	COG3629	intracellular signal transduction
I6J43_RS12945	COG0577	efflux transmembrane transporter activity
I6J43_RS12950	COG1136	(ABC) transporter
I6J43_RS12955	COG0477	Major facilitator Superfamily
I6J43_RS12960	COG0346	lactoylglutathione lyase activity
I6J43_RS13005	COG2124	cytochrome p450
I6J43_RS13035	COG2226	methyltransferase
I6J43_RS13050	COG4585	Histidine kinase
I6J43_RS13060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J43_RS13065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J43_RS13070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J43_RS13075	COG0193	aminoacyl-tRNA hydrolase activity
I6J43_RS13080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J43_RS13105	COG4106	trans-aconitate 2-methyltransferase activity
I6J43_RS13110	COG1846	Transcriptional regulator
I6J43_RS13115	COG2197	response regulator
I6J43_RS13125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J43_RS13140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J43_RS13165	COG0488	(ABC) transporter
I6J43_RS13185	COG2161	toxin-antitoxin pair type II binding
I6J43_RS13190	COG4115	mRNA cleavage
I6J43_RS13205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J43_RS13210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J43_RS13215	COG0084	hydrolase, TatD family'
I6J43_RS13245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J43_RS13290	COG2223	nitrite transmembrane transporter activity
I6J43_RS13295	COG2207	Transcriptional regulator
I6J43_RS13300	COG0442	prolyl-tRNA aminoacylation
I6J43_RS13320	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I6J43_RS13325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J43_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS13350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J43_RS13360	COG2409	Drug exporters of the RND superfamily
I6J43_RS13370	COG4946	Tricorn protease homolog
I6J43_RS13370	COG0793	Belongs to the peptidase S41A family
I6J43_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS13390	COG2072	flavoprotein involved in K transport
I6J43_RS13400	COG0708	Exodeoxyribonuclease III
I6J43_RS13430	COG2340	Cysteine-rich secretory protein family
I6J43_RS13450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J43_RS13470	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J43_RS13475	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J43_RS13485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J43_RS13490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J43_RS13515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J43_RS13540	COG0437	4 iron, 4 sulfur cluster binding
I6J43_RS13545	COG0243	molybdopterin cofactor binding
I6J43_RS13565	COG0477	Major facilitator Superfamily
I6J43_RS13585	COG3384	dioxygenase
I6J43_RS13590	COG1846	Transcriptional regulator
I6J43_RS13610	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS13670	COG1686	Belongs to the peptidase S11 family
I6J43_RS13775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J43_RS13790	COG3386	PFAM SMP-30 Gluconolaconase
I6J43_RS13795	COG0768	penicillin binding
I6J43_RS13895	COG1196	nuclear chromosome segregation
I6J43_RS13895	COG0739	heme binding
I6J43_RS13895	COG0741	lytic transglycosylase activity
I6J43_RS13915	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
I6J43_RS13925	COG0183	Belongs to the thiolase family
I6J43_RS13930	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS13945	COG2208	phosphoserine phosphatase activity
I6J43_RS13945	COG2770	Histidine kinase
I6J43_RS13965	COG1309	transcriptional regulator
I6J43_RS13975	COG1301	dicarboxylic acid transport
I6J43_RS13985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J43_RS13995	COG0163	prenyltransferase activity
I6J43_RS14010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J43_RS14020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J43_RS14025	COG1333	cytochrome c biogenesis protein
I6J43_RS14030	COG0785	Cytochrome C biogenesis protein
I6J43_RS14035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J43_RS14045	COG0406	alpha-ribazole phosphatase activity
I6J43_RS14050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J43_RS14080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J43_RS14085	COG1690	Belongs to the RtcB family
I6J43_RS14150	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6J43_RS14155	COG0018	arginyl-trna synthetase
I6J43_RS14195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J43_RS14235	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS14240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS14245	COG0515	serine threonine protein kinase
I6J43_RS14285	COG2267	carboxylic ester hydrolase activity
I6J43_RS14325	COG0671	phosphoesterase, PA-phosphatase related
I6J43_RS14340	COG0667	Aldo Keto reductase
I6J43_RS14345	COG1309	transcriptional regulator
I6J43_RS14375	COG2252	PERMEase
I6J43_RS14385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J43_RS14405	COG2814	Major facilitator Superfamily
I6J43_RS14415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J43_RS14420	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J43_RS14430	COG1278	Cold shock
I6J43_RS14455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS14460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS14465	COG1120	ATPase activity
I6J43_RS14470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J43_RS14520	COG1061	Type III restriction enzyme res subunit
I6J43_RS14530	COG1120	ATPase activity
I6J43_RS14560	COG3973	AAA domain
I6J43_RS14580	COG1984	allophanate hydrolase subunit 2
I6J43_RS14590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J43_RS14600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J43_RS14605	COG0640	Transcriptional regulator
I6J43_RS14610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J43_RS14630	COG1737	Transcriptional regulator
I6J43_RS14635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J43_RS14660	COG4257	antibiotic catabolic process
I6J43_RS14705	COG2204	response regulator
I6J43_RS14710	COG4251	negative regulation of phosphorylation
I6J43_RS14750	COG1175	transmembrane transport
I6J43_RS14755	COG0395	ABC-type sugar transport system, permease component
I6J43_RS14775	COG2318	DinB family
I6J43_RS14790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J43_RS14795	COG0546	phosphoglycolate phosphatase activity
I6J43_RS14855	COG1595	DNA-templated transcription, initiation
I6J43_RS14860	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J43_RS14860	COG2319	Wd-40 repeat
I6J43_RS14875	COG1132	(ABC) transporter
I6J43_RS14925	COG0463	Glycosyl transferase, family 2
I6J43_RS14940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6J43_RS14965	COG2197	response regulator
I6J43_RS15005	COG0577	efflux transmembrane transporter activity
I6J43_RS15005	COG1136	(ABC) transporter
I6J43_RS15015	COG2197	response regulator
I6J43_RS15060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J43_RS15065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J43_RS15070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J43_RS15070	COG1754	DNA topoisomerase type I activity
I6J43_RS15080	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J43_RS15090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J43_RS15100	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS15105	COG1205	dead DEAH box helicase
I6J43_RS15105	COG1111	helicase
I6J43_RS15165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J43_RS15170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J43_RS15180	COG2267	carboxylic ester hydrolase activity
I6J43_RS15205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J43_RS15215	COG0251	oxidation-reduction process
I6J43_RS15230	COG0003	Pfam Anion-transporting ATPase
I6J43_RS15240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J43_RS15245	COG1610	YqeY-like protein
I6J43_RS15250	COG1408	metallophosphoesterase
I6J43_RS15265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J43_RS15270	COG2755	lipolytic protein G-D-S-L family
I6J43_RS15280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J43_RS15300	COG1595	DNA-templated transcription, initiation
I6J43_RS15330	COG0702	epimerase
I6J43_RS15340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J43_RS15345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J43_RS15360	COG1802	Transcriptional regulator
I6J43_RS15365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J43_RS15370	COG0693	protein deglycase activity
I6J43_RS15380	COG2124	cytochrome p450
I6J43_RS15390	COG0738	Major facilitator superfamily
I6J43_RS15395	COG3226	Transcriptional regulator
I6J43_RS15400	COG0667	Aldo Keto reductase
I6J43_RS15425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS15435	COG0662	Cupin 2, conserved barrel domain protein
I6J43_RS15440	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS15495	COG0590	tRNA wobble adenosine to inosine editing
I6J43_RS15505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J43_RS15535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J43_RS15555	COG2124	cytochrome p450
I6J43_RS15560	COG2197	response regulator
I6J43_RS15565	COG4585	Histidine kinase
I6J43_RS15570	COG0702	epimerase
I6J43_RS15580	COG3844	kynureninase activity
I6J43_RS15595	COG0477	Major facilitator Superfamily
I6J43_RS15600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J43_RS15605	COG0191	fructose-bisphosphate aldolase activity
I6J43_RS15610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J43_RS15625	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6J43_RS15645	COG0542	response to heat
I6J43_RS15690	COG0789	Transcriptional regulator
I6J43_RS15695	COG0484	heat shock protein binding
I6J43_RS15700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J43_RS15705	COG0443	Heat shock 70 kDa protein
I6J43_RS15710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J43_RS15715	COG0247	lactate metabolic process
I6J43_RS15715	COG2181	nitrate reductase activity
I6J43_RS15735	COG0717	Belongs to the dCTP deaminase family
I6J43_RS15775	COG3209	COG3209 Rhs family protein
I6J43_RS15795	COG1309	transcriptional regulator
I6J43_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS15805	COG1278	Cold shock
I6J43_RS15875	COG2205	protein histidine kinase activity
I6J43_RS15880	COG0745	RESPONSE REGULATOR receiver
I6J43_RS15945	COG2409	Drug exporters of the RND superfamily
I6J43_RS15955	COG0513	Belongs to the DEAD box helicase family
I6J43_RS15960	COG1278	Cold shock
I6J43_RS16010	COG0450	alkyl hydroperoxide reductase
I6J43_RS16020	COG2268	Band 7 protein
I6J43_RS16075	COG0490	domain, Protein
I6J43_RS16080	COG0475	glutathione-regulated potassium exporter activity
I6J43_RS16085	COG0181	hydroxymethylbilane synthase activity
I6J43_RS16110	COG2255	four-way junction helicase activity
I6J43_RS16120	COG0180	Tryptophanyl-tRNA synthetase
I6J43_RS16125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS16160	COG0431	NADPH-dependent FMN reductase
I6J43_RS16185	COG2304	oxidoreductase activity
I6J43_RS16190	COG2205	protein histidine kinase activity
I6J43_RS16195	COG0745	RESPONSE REGULATOR receiver
I6J43_RS16200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J43_RS16215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J43_RS16230	COG1741	Belongs to the pirin family
I6J43_RS16240	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS16250	COG1362	aminopeptidase activity
I6J43_RS16260	COG3903	Transcriptional regulator
I6J43_RS16260	COG3629	intracellular signal transduction
I6J43_RS16285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J43_RS16295	COG2271	Major facilitator Superfamily
I6J43_RS16300	COG1802	Transcriptional regulator
I6J43_RS16310	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J43_RS16315	COG0022	dehydrogenase e1 component
I6J43_RS16340	COG0515	serine threonine protein kinase
I6J43_RS16345	COG0515	serine threonine protein kinase
I6J43_RS16360	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J43_RS16360	COG1136	(ABC) transporter
I6J43_RS16385	COG0303	'Molybdopterin
I6J43_RS16410	COG1522	sequence-specific DNA binding
I6J43_RS16415	COG1309	transcriptional regulator
I6J43_RS16440	COG3396	Phenylacetate-CoA oxygenase
I6J43_RS16445	COG3460	Phenylacetate-CoA oxygenase
I6J43_RS16450	COG3396	Phenylacetate-CoA oxygenase
I6J43_RS16455	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J43_RS16460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J43_RS16495	COG1716	ATPase activity
I6J43_RS16500	COG1716	ATPase activity
I6J43_RS16515	COG0768	penicillin binding
I6J43_RS16520	COG0515	serine threonine protein kinase
I6J43_RS16525	COG3764	Sortase (surface protein transpeptidase)
I6J43_RS16530	COG3764	Sortase (surface protein transpeptidase)
I6J43_RS16545	COG3764	Sortase (surface protein transpeptidase)
I6J43_RS16585	COG0515	serine threonine protein kinase
I6J43_RS16630	COG0582	viral genome integration into host DNA
I6J43_RS16645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J43_RS16655	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J43_RS16660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J43_RS16665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J43_RS16670	COG0592	DNA-directed DNA polymerase activity
I6J43_RS16685	COG0594	ribonuclease P activity
I6J43_RS16690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J43_RS16695	COG0706	membrane insertase activity
I6J43_RS16705	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J43_RS16710	COG1192	Involved in chromosome partitioning
I6J43_RS16725	COG3118	belongs to the thioredoxin family
I6J43_RS16730	COG0492	ferredoxin-NADP+ reductase activity
I6J43_RS16740	COG1595	DNA-templated transcription, initiation
I6J43_RS16745	COG0515	serine threonine protein kinase
I6J43_RS16745	COG2815	serine threonine protein kinase
I6J43_RS16760	COG0617	tRNA 3'-terminal CCA addition
I6J43_RS16780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J43_RS16805	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J43_RS16810	COG0629	single-stranded DNA binding
I6J43_RS16815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J43_RS16820	COG0359	binds to the 23S rRNA
I6J43_RS16830	COG0305	Participates in initiation and elongation during chromosome replication
I6J43_RS16855	COG2814	Major facilitator Superfamily
I6J43_RS16870	COG0626	cystathionine gamma-synthase activity
I6J43_RS16875	COG1950	PFAM Membrane protein of
I6J43_RS16880	COG0662	Cupin 2, conserved barrel domain protein
I6J43_RS16905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J43_RS16915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J43_RS16920	COG1609	Transcriptional regulator
I6J43_RS16925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J43_RS16930	COG1271	oxidase subunit
I6J43_RS16935	COG1294	oxidase, subunit
I6J43_RS16940	COG4988	ABC transporter
I6J43_RS16950	COG0561	phosphatase activity
I6J43_RS16960	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J43_RS16965	COG0789	Transcriptional regulator
I6J43_RS16980	COG1131	(ABC) transporter
I6J43_RS17005	COG0561	phosphatase activity
I6J43_RS17010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J43_RS17020	COG2837	iron assimilation
I6J43_RS17025	COG2372	response to copper ion
I6J43_RS17035	COG1999	signal sequence binding
I6J43_RS17055	COG0006	proline dipeptidase activity
I6J43_RS17070	COG0653	protein targeting
I6J43_RS17085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J43_RS17110	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS17135	COG1595	DNA-templated transcription, initiation
I6J43_RS17140	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS17175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J43_RS17200	COG0494	nUDIX hydrolase
I6J43_RS17220	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J43_RS17230	COG1252	NADH dehydrogenase
I6J43_RS17235	COG1595	DNA-templated transcription, initiation
I6J43_RS17255	COG0745	RESPONSE REGULATOR receiver
I6J43_RS17270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J43_RS17280	COG0477	Major facilitator Superfamily
I6J43_RS17295	COG3467	pyridoxamine 5'-phosphate
I6J43_RS17300	COG2353	YceI-like domain
I6J43_RS17325	COG1191	sigma factor activity
I6J43_RS17330	COG1191	sigma factor activity
I6J43_RS17370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J43_RS17385	COG2234	aminopeptidase activity
I6J43_RS17405	COG2197	response regulator
I6J43_RS17420	COG0464	growth
I6J43_RS17500	COG4941	Belongs to the sigma-70 factor family
I6J43_RS17550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J43_RS17670	COG0492	ferredoxin-NADP+ reductase activity
I6J43_RS17695	COG0151	Belongs to the GarS family
I6J43_RS17710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J43_RS17720	COG2197	response regulator
I6J43_RS17735	COG1131	(ABC) transporter
I6J43_RS17755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J43_RS17760	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J43_RS17765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J43_RS17775	COG1196	nuclear chromosome segregation
I6J43_RS17775	COG0739	heme binding
I6J43_RS17775	COG0741	lytic transglycosylase activity
I6J43_RS17790	COG3119	arylsulfatase activity
I6J43_RS17800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J43_RS17810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J43_RS17830	COG1643	Atp-dependent helicase
I6J43_RS17840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J43_RS17840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J43_RS17845	COG0785	Cytochrome C biogenesis protein
I6J43_RS17880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J43_RS17890	COG0513	Belongs to the DEAD box helicase family
I6J43_RS17900	COG0596	Alpha beta hydrolase
I6J43_RS17905	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS17915	COG0596	Alpha beta hydrolase
I6J43_RS17925	COG1191	sigma factor activity
I6J43_RS17940	COG1937	Protein conserved in bacteria
I6J43_RS17955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J43_RS17955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J43_RS17960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J43_RS17965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J43_RS17985	COG0739	heme binding
I6J43_RS17985	COG0741	lytic transglycosylase activity
I6J43_RS17985	COG1196	nuclear chromosome segregation
I6J43_RS18000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J43_RS18005	COG0579	oxidoreductase
I6J43_RS18030	COG1252	NADH dehydrogenase
I6J43_RS18045	COG1846	Transcriptional regulator
I6J43_RS18065	COG2197	response regulator
I6J43_RS18070	COG4585	Histidine kinase
I6J43_RS18150	COG1196	nuclear chromosome segregation
I6J43_RS18150	COG0741	lytic transglycosylase activity
I6J43_RS18150	COG0739	heme binding
I6J43_RS18155	COG0671	phosphoesterase, PA-phosphatase related
I6J43_RS18175	COG1937	Protein conserved in bacteria
I6J43_RS18185	COG0306	phosphate transporter
I6J43_RS18205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J43_RS18210	COG0494	nUDIX hydrolase
I6J43_RS18210	COG0406	alpha-ribazole phosphatase activity
I6J43_RS18230	COG1725	Transcriptional regulator
I6J43_RS18240	COG0456	acetyltransferase
I6J43_RS18250	COG0737	Belongs to the 5'-nucleotidase family
I6J43_RS18255	COG4106	trans-aconitate 2-methyltransferase activity
I6J43_RS18280	COG0154	amidase activity
I6J43_RS18295	COG4977	sequence-specific DNA binding
I6J43_RS18310	COG0739	heme binding
I6J43_RS18345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J43_RS18350	COG1609	Transcriptional regulator
I6J43_RS18355	COG0745	RESPONSE REGULATOR receiver
I6J43_RS18380	COG2897	thiosulfate sulfurtransferase activity
I6J43_RS18400	COG3485	protocatechuate 3,4-dioxygenase
I6J43_RS18405	COG0735	belongs to the Fur family
I6J43_RS18415	COG1490	D-aminoacyl-tRNA deacylase activity
I6J43_RS18430	COG4552	Acetyltransferase involved in intracellular survival and related
I6J43_RS18470	COG4942	peptidase
I6J43_RS18545	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS18600	COG0640	Transcriptional regulator
I6J43_RS18605	COG0798	PFAM Bile acid sodium symporter
I6J43_RS18610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J43_RS18620	COG0588	phosphoglycerate mutase activity
I6J43_RS18640	COG5002	protein histidine kinase activity
I6J43_RS18655	COG1329	Transcriptional regulator
I6J43_RS18660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J43_RS18665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J43_RS18680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS18690	COG3467	pyridoxamine 5'-phosphate
I6J43_RS18695	COG0215	cysteine-tRNA ligase activity
I6J43_RS18720	COG3842	ATPase activity
I6J43_RS18780	COG0745	RESPONSE REGULATOR receiver
I6J43_RS18825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J43_RS18845	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J43_RS18865	COG2197	response regulator
I6J43_RS18900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J43_RS18925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J43_RS18935	COG1653	transport
I6J43_RS18995	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS19025	COG0076	glutamate decarboxylase activity
I6J43_RS19030	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J43_RS19040	COG0393	Putative heavy-metal-binding
I6J43_RS19045	COG0586	Pfam SNARE associated Golgi protein
I6J43_RS19055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J43_RS19060	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J43_RS19070	COG0037	tRNA processing
I6J43_RS19085	COG0302	gtp cyclohydrolase
I6J43_RS19100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J43_RS19115	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J43_RS19115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J43_RS19125	COG0517	IMP dehydrogenase activity
I6J43_RS19125	COG1125	glycine betaine transport
I6J43_RS19130	COG1174	glycine betaine transport
I6J43_RS19135	COG1174	glycine betaine transport
I6J43_RS19150	COG0649	NAD binding
I6J43_RS19165	COG2197	response regulator
I6J43_RS19170	COG1660	Displays ATPase and GTPase activities
I6J43_RS19195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J43_RS19200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J43_RS19210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J43_RS19230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J43_RS19260	COG0739	heme binding
I6J43_RS19265	COG2205	protein histidine kinase activity
I6J43_RS19270	COG0745	RESPONSE REGULATOR receiver
I6J43_RS19280	COG1595	DNA-templated transcription, initiation
I6J43_RS19285	COG1194	a g-specific adenine glycosylase
I6J43_RS19295	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6J43_RS19315	COG0248	Ppx GppA phosphatase
I6J43_RS19320	COG1082	Xylose isomerase domain protein TIM barrel
I6J43_RS19330	COG0129	dihydroxy-acid dehydratase activity
I6J43_RS19335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J43_RS19335	COG0515	serine threonine protein kinase
I6J43_RS19340	COG4991	sh3 domain protein
I6J43_RS19350	COG0842	Transport permease protein
I6J43_RS19350	COG1129	ABC transporter
I6J43_RS19360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J43_RS19380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS19440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J43_RS19445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J43_RS19450	COG0181	hydroxymethylbilane synthase activity
I6J43_RS19455	COG1648	precorrin-2 dehydrogenase activity
I6J43_RS19455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J43_RS19460	COG0113	porphobilinogen synthase activity
I6J43_RS19495	COG2318	DinB family
I6J43_RS19530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J43_RS19555	COG2161	toxin-antitoxin pair type II binding
I6J43_RS19595	COG1136	(ABC) transporter
I6J43_RS19595	COG0577	efflux transmembrane transporter activity
I6J43_RS19615	COG0745	RESPONSE REGULATOR receiver
I6J43_RS19620	COG2205	protein histidine kinase activity
I6J43_RS19640	COG1309	transcriptional regulator
I6J43_RS19700	COG1335	isochorismatase
I6J43_RS19715	COG2318	DinB family
I6J43_RS19725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J43_RS19755	COG2205	protein histidine kinase activity
I6J43_RS19760	COG0277	FAD linked oxidase domain protein
I6J43_RS19760	COG0247	lactate metabolic process
I6J43_RS19765	COG0583	DNA-binding transcription factor activity
I6J43_RS19770	COG5006	permease, DMT superfamily
I6J43_RS19775	COG4221	oxidoreductase activity
I6J43_RS19780	COG1309	transcriptional regulator
I6J43_RS19805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J43_RS19820	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS19825	COG1024	Enoyl-CoA hydratase
I6J43_RS19890	COG1396	sequence-specific DNA binding
I6J43_RS19910	COG0259	pyridoxamine-phosphate oxidase activity
I6J43_RS19920	COG4821	SIS domain
I6J43_RS19975	COG0604	alcohol dehydrogenase
I6J43_RS20005	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS20015	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS20025	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS20030	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS20050	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS20090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J43_RS20095	COG1024	Enoyl-CoA hydratase
I6J43_RS20120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J43_RS20130	COG2072	flavoprotein involved in K transport
I6J43_RS20145	COG2124	cytochrome p450
I6J43_RS20160	COG0501	Belongs to the peptidase M48B family
I6J43_RS20185	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS20195	COG1309	transcriptional regulator
I6J43_RS20220	COG1024	Enoyl-CoA hydratase
I6J43_RS20235	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS20265	COG0789	Transcriptional regulator
I6J43_RS20270	COG1278	Cold shock
I6J43_RS20275	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I6J43_RS20285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J43_RS20310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J43_RS20315	COG4521	taurine ABC transporter
I6J43_RS20325	COG2175	clavaminate synthase activity
I6J43_RS20330	COG2226	methyltransferase
I6J43_RS20395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20405	COG0649	NAD binding
I6J43_RS20415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J43_RS20420	COG1034	ATP synthesis coupled electron transport
I6J43_RS20425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J43_RS20430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20435	COG0839	Belongs to the complex I subunit 6 family
I6J43_RS20440	COG0713	ATP synthesis coupled electron transport
I6J43_RS20445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J43_RS20455	COG1007	ATP synthesis coupled electron transport
I6J43_RS20460	COG0514	ATP-dependent DNA helicase (RecQ)
I6J43_RS20495	COG3104	oligopeptide transport
I6J43_RS20500	COG0142	geranyltranstransferase activity
I6J43_RS20525	COG0515	serine threonine protein kinase
I6J43_RS20525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J43_RS20540	COG0789	Transcriptional regulator
I6J43_RS20545	COG4221	oxidoreductase activity
I6J43_RS20565	COG0561	phosphatase activity
I6J43_RS20580	COG0667	Aldo Keto reductase
I6J43_RS20670	COG0702	epimerase
I6J43_RS20675	COG1733	regulation of RNA biosynthetic process
I6J43_RS20680	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J43_RS20685	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J43_RS20685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J43_RS20700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20715	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J43_RS20720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J43_RS20725	COG0839	Belongs to the complex I subunit 6 family
I6J43_RS20730	COG0713	ATP synthesis coupled electron transport
I6J43_RS20735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J43_RS20745	COG1007	ATP synthesis coupled electron transport
I6J43_RS20750	COG1970	mechanosensitive ion channel activity
I6J43_RS20755	COG0501	Belongs to the peptidase M48B family
I6J43_RS20760	COG3304	Inner membrane component domain
I6J43_RS20775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J43_RS20780	COG1666	GTP binding
I6J43_RS20790	COG0702	epimerase
I6J43_RS20810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J43_RS20815	COG2030	dehydratase
I6J43_RS20835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J43_RS20840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J43_RS20845	COG0436	Aminotransferase
I6J43_RS20865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J43_RS20870	COG0081	regulation of translation
I6J43_RS20880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J43_RS20885	COG0222	ribosome binding
I6J43_RS20890	COG0085	RNA polymerase activity
I6J43_RS20895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J43_RS20900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J43_RS20980	COG1196	nuclear chromosome segregation
I6J43_RS20980	COG0741	lytic transglycosylase activity
I6J43_RS20980	COG0739	heme binding
I6J43_RS20995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J43_RS21000	COG0049	tRNA binding
I6J43_RS21005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J43_RS21010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J43_RS21015	COG4585	Histidine kinase
I6J43_RS21020	COG2197	response regulator
I6J43_RS21035	COG0051	transcription antitermination factor activity, RNA binding
I6J43_RS21040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J43_RS21045	COG0088	Forms part of the polypeptide exit tunnel
I6J43_RS21050	COG0089	rRNA binding
I6J43_RS21055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J43_RS21060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J43_RS21065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J43_RS21070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J43_RS21075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J43_RS21080	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J43_RS21085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J43_RS21090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J43_RS21095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J43_RS21100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J43_RS21105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J43_RS21110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J43_RS21115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J43_RS21120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J43_RS21125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J43_RS21130	COG1841	ribosomal large subunit assembly
I6J43_RS21135	COG0200	Binds to the 23S rRNA
I6J43_RS21145	COG0563	adenylate kinase activity
I6J43_RS21155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J43_RS21160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J43_RS21165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J43_RS21170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J43_RS21175	COG0202	RNA polymerase activity
I6J43_RS21180	COG0203	ribosomal protein L17
I6J43_RS21185	COG0101	tRNA pseudouridine synthase activity
I6J43_RS21195	COG0488	(ABC) transporter
I6J43_RS21200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J43_RS21205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J43_RS21210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J43_RS21220	COG1072	(Pantothenic acid kinase))
I6J43_RS21300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J43_RS21305	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J43_RS21315	COG3189	MarR family transcriptional regulator
I6J43_RS21330	COG0802	atpase or kinase
I6J43_RS21355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J43_RS21390	COG0726	polysaccharide deacetylase
I6J43_RS21400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J43_RS21415	COG2132	Multicopper oxidase
I6J43_RS21430	COG0583	DNA-binding transcription factor activity
I6J43_RS21445	COG1595	DNA-templated transcription, initiation
I6J43_RS21455	COG0516	GMP reductase activity
I6J43_RS21470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J43_RS21485	COG0515	serine threonine protein kinase
I6J43_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS21510	COG0519	Catalyzes the synthesis of GMP from XMP
I6J43_RS21510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J43_RS21520	COG4106	trans-aconitate 2-methyltransferase activity
I6J43_RS21550	COG2197	response regulator
I6J43_RS21575	COG0739	heme binding
I6J43_RS21585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J43_RS21605	COG0714	Associated with various cellular activities
I6J43_RS21615	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J43_RS21620	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J43_RS21650	COG0138	bifunctional purine biosynthesis protein purh
I6J43_RS21665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J43_RS21680	COG0039	L-malate dehydrogenase activity
I6J43_RS21700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J43_RS21705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J43_RS21715	COG0754	glutathionylspermidine amidase activity
I6J43_RS21720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J43_RS21725	COG0180	Tryptophanyl-tRNA synthetase
I6J43_RS21745	COG1295	ribonuclease BN
I6J43_RS21760	COG1408	metallophosphoesterase
I6J43_RS21795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J43_RS21800	COG1053	succinate dehydrogenase
I6J43_RS21810	COG2009	succinate dehydrogenase
I6J43_RS21860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J43_RS21865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J43_RS21870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J43_RS21910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J43_RS21915	COG1595	DNA-templated transcription, initiation
I6J43_RS21960	COG1216	Glycosyl transferase, family 2
I6J43_RS21970	COG1083	cytidylyl-transferase
I6J43_RS21975	COG2089	acid synthase
I6J43_RS22000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J43_RS22000	COG1473	amidohydrolase
I6J43_RS22005	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J43_RS22010	COG3845	ABC transporter
I6J43_RS22015	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J43_RS22020	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J43_RS22040	COG1404	Belongs to the peptidase S8 family
I6J43_RS22060	COG2814	Major facilitator Superfamily
I6J43_RS22065	COG0583	DNA-binding transcription factor activity
I6J43_RS22085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J43_RS22110	COG2205	protein histidine kinase activity
I6J43_RS22115	COG0745	RESPONSE REGULATOR receiver
I6J43_RS22120	COG1595	DNA-templated transcription, initiation
I6J43_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS22140	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS22155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J43_RS22185	COG4770	biotin carboxylase activity
I6J43_RS22195	COG0424	maF-like protein
I6J43_RS22205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J43_RS22220	COG1024	Enoyl-CoA hydratase
I6J43_RS22245	COG1376	ErfK ybiS ycfS ynhG family protein
I6J43_RS22265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J43_RS22275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J43_RS22280	COG0583	DNA-binding transcription factor activity
I6J43_RS22295	COG0501	Belongs to the peptidase M48B family
I6J43_RS22320	COG1595	DNA-templated transcription, initiation
I6J43_RS22325	COG0745	RESPONSE REGULATOR receiver
I6J43_RS22330	COG5002	protein histidine kinase activity
I6J43_RS22330	COG2198	Histidine kinase
I6J43_RS22330	COG0784	Response regulator, receiver
I6J43_RS22340	COG2172	sigma factor antagonist activity
I6J43_RS22345	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS22350	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J43_RS22360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J43_RS22375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J43_RS22385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J43_RS22410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J43_RS22430	COG0300	oxidoreductase activity
I6J43_RS22430	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS22430	COG0300	oxidoreductase activity
I6J43_RS22430	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS22430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS22430	COG3321	synthase
I6J43_RS22430	COG3321	synthase
I6J43_RS22430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS22435	COG3251	PFAM MbtH domain protein
I6J43_RS22465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J43_RS22470	COG2175	clavaminate synthase activity
I6J43_RS22475	COG2197	response regulator
I6J43_RS22480	COG0577	efflux transmembrane transporter activity
I6J43_RS22480	COG1136	(ABC) transporter
I6J43_RS22490	COG4585	Histidine kinase
I6J43_RS22520	COG0154	amidase activity
I6J43_RS22545	COG1331	Highly conserved protein containing a thioredoxin domain
I6J43_RS22555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J43_RS22565	COG0436	Aminotransferase
I6J43_RS22585	COG1733	regulation of RNA biosynthetic process
I6J43_RS22605	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J43_RS22620	COG1414	Transcriptional regulator
I6J43_RS22625	COG0251	oxidation-reduction process
I6J43_RS22630	COG2610	gluconate transmembrane transporter activity
I6J43_RS22655	COG2894	cell division
I6J43_RS22690	COG2197	response regulator
I6J43_RS22710	COG2885	chlorophyll binding
I6J43_RS22775	COG2226	methyltransferase
I6J43_RS22785	COG0667	Aldo Keto reductase
I6J43_RS22790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J43_RS22795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J43_RS22810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J43_RS22815	COG0450	alkyl hydroperoxide reductase
I6J43_RS22830	COG1136	(ABC) transporter
I6J43_RS22850	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J43_RS22850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J43_RS22865	COG0114	fumarate hydratase activity
I6J43_RS22875	COG1362	aminopeptidase activity
I6J43_RS22905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J43_RS22905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J43_RS22930	COG0778	Nitroreductase
I6J43_RS22935	COG1722	exodeoxyribonuclease VII activity
I6J43_RS22940	COG1570	exodeoxyribonuclease VII activity
I6J43_RS22950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J43_RS22965	COG0012	GTP binding
I6J43_RS22975	COG0477	Major facilitator Superfamily
I6J43_RS22985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J43_RS23115	COG0789	Transcriptional regulator
I6J43_RS23170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6J43_RS23185	COG2409	Drug exporters of the RND superfamily
I6J43_RS23190	COG4585	Histidine kinase
I6J43_RS23195	COG2197	response regulator
I6J43_RS23200	COG0154	amidase activity
I6J43_RS23215	COG1217	gtp-binding protein TYPA
I6J43_RS23225	COG0601	transmembrane transport
I6J43_RS23230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS23240	COG4608	Belongs to the ABC transporter superfamily
I6J43_RS23245	COG4166	transmembrane transport
I6J43_RS23250	COG0601	transmembrane transport
I6J43_RS23255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS23265	COG4608	Belongs to the ABC transporter superfamily
I6J43_RS23280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J43_RS23300	COG0110	maltose O-acetyltransferase activity
I6J43_RS23315	COG0515	serine threonine protein kinase
I6J43_RS23330	COG1132	(ABC) transporter
I6J43_RS23335	COG2197	response regulator
I6J43_RS23340	COG2912	Transglutaminase-like superfamily
I6J43_RS23370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J43_RS23375	COG1611	Belongs to the LOG family
I6J43_RS23380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J43_RS23390	COG0519	Catalyzes the synthesis of GMP from XMP
I6J43_RS23395	COG1024	Enoyl-CoA hydratase
I6J43_RS23410	COG1595	DNA-templated transcription, initiation
I6J43_RS23420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J43_RS23425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J43_RS23460	COG0598	Magnesium transport protein CorA
I6J43_RS23470	COG2814	Major facilitator Superfamily
I6J43_RS23485	COG2095	MarC family integral membrane protein
I6J43_RS23495	COG1432	Conserved Protein
I6J43_RS23505	COG0513	Belongs to the DEAD box helicase family
I6J43_RS23545	COG0747	negative chemotaxis
I6J43_RS23555	COG0601	transmembrane transport
I6J43_RS23560	COG4172	Belongs to the ABC transporter superfamily
I6J43_RS23605	COG0210	DNA helicase
I6J43_RS23705	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J43_RS23715	COG1615	UPF0182 protein
I6J43_RS23740	COG0753	catalase activity
I6J43_RS23750	COG0483	inositol monophosphate 1-phosphatase activity
I6J43_RS23760	COG2076	Multidrug Resistance protein
I6J43_RS23770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J43_RS23780	COG2135	peptidase activity
I6J43_RS23790	COG1595	DNA-templated transcription, initiation
I6J43_RS23795	COG5662	AntiSigma factor
I6J43_RS23805	COG0242	peptide deformylase activity
I6J43_RS23840	COG1966	Carbon starvation protein
I6J43_RS23845	COG2188	Transcriptional regulator
I6J43_RS23850	COG2182	Extracellular solute-binding protein
I6J43_RS23855	COG1175	transmembrane transport
I6J43_RS23860	COG0395	ABC-type sugar transport system, permease component
I6J43_RS23865	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J43_RS23870	COG0363	glucosamine-6-phosphate deaminase activity
I6J43_RS23875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J43_RS23890	COG1597	lipid kinase activity
I6J43_RS23930	COG1959	2 iron, 2 sulfur cluster binding
I6J43_RS23935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J43_RS23940	COG0142	geranyltranstransferase activity
I6J43_RS24005	COG2197	response regulator
I6J43_RS24010	COG4585	Histidine kinase
I6J43_RS24030	COG1695	Transcriptional regulator
I6J43_RS24065	COG0242	peptide deformylase activity
I6J43_RS24090	COG4106	trans-aconitate 2-methyltransferase activity
I6J43_RS24095	COG1595	DNA-templated transcription, initiation
I6J43_RS24105	COG1126	abc transporter atp-binding protein
I6J43_RS24110	COG0765	amino acid transport
I6J43_RS24115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS24120	COG0281	malic enzyme
I6J43_RS24125	COG0604	alcohol dehydrogenase
I6J43_RS24145	COG0542	response to heat
I6J43_RS24170	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J43_RS24170	COG0567	Dehydrogenase, E1 component
I6J43_RS24175	COG2205	protein histidine kinase activity
I6J43_RS24180	COG0745	RESPONSE REGULATOR receiver
I6J43_RS24190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J43_RS24195	COG0726	polysaccharide deacetylase
I6J43_RS24255	COG1309	transcriptional regulator
I6J43_RS24305	COG2205	protein histidine kinase activity
I6J43_RS24325	COG1793	dna ligase
I6J43_RS24325	COG3285	dna ligase
I6J43_RS24330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J43_RS24335	COG0515	serine threonine protein kinase
I6J43_RS24345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J43_RS24370	COG0018	arginyl-trna synthetase
I6J43_RS24375	COG0019	diaminopimelate decarboxylase activity
I6J43_RS24380	COG0460	homoserine dehydrogenase
I6J43_RS24385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J43_RS24390	COG0083	homoserine kinase activity
I6J43_RS24400	COG1316	TRANSCRIPTIONal
I6J43_RS24405	COG0254	rRNA binding
I6J43_RS24410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J43_RS24415	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J43_RS24425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J43_RS24430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J43_RS24450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J43_RS24455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J43_RS24460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J43_RS24465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J43_RS24470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J43_RS24475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J43_RS24480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J43_RS24495	COG2197	response regulator
I6J43_RS24500	COG4585	Histidine kinase
I6J43_RS24530	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS24545	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J43_RS24600	COG0183	Belongs to the thiolase family
I6J43_RS24615	COG0745	RESPONSE REGULATOR receiver
I6J43_RS24620	COG5000	phosphorelay sensor kinase activity
I6J43_RS24620	COG5002	protein histidine kinase activity
I6J43_RS24690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J43_RS24690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J43_RS24735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J43_RS24740	COG0280	phosphate acetyltransferase
I6J43_RS24740	COG0857	belongs to the CobB CobQ family
I6J43_RS24745	COG0205	6-phosphofructokinase activity
I6J43_RS24755	COG4565	transcriptional regulatory protein
I6J43_RS24760	COG3290	protein histidine kinase activity
I6J43_RS24765	COG1301	dicarboxylic acid transport
I6J43_RS24790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J43_RS24800	COG0366	Alpha amylase catalytic
I6J43_RS24805	COG0366	Alpha amylase catalytic
I6J43_RS24810	COG0058	SHG alpha-glucan phosphorylase activity
I6J43_RS24830	COG0387	Pfam Sodium calcium exchanger
I6J43_RS24850	COG1742	UPF0060 membrane protein
I6J43_RS24855	COG1132	(ABC) transporter
I6J43_RS24865	COG1131	(ABC) transporter
I6J43_RS24880	COG2197	response regulator
I6J43_RS24930	COG0515	serine threonine protein kinase
I6J43_RS25030	COG0823	Involved in the tonB-independent uptake of proteins
I6J43_RS25030	COG1506	peptidase
I6J43_RS25040	COG0464	growth
I6J43_RS25070	COG1760	l-serine dehydratase
I6J43_RS25075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J43_RS25080	COG0509	glycine decarboxylation via glycine cleavage system
I6J43_RS25085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J43_RS25105	COG0747	negative chemotaxis
I6J43_RS25110	COG0601	transmembrane transport
I6J43_RS25115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS25125	COG4608	Belongs to the ABC transporter superfamily
I6J43_RS25130	COG2860	membrane
I6J43_RS25140	COG2378	regulation of single-species biofilm formation
I6J43_RS25170	COG0482	sulfurtransferase activity
I6J43_RS25190	COG4221	oxidoreductase activity
I6J43_RS25200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J43_RS25210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J43_RS25215	COG0154	amidase activity
I6J43_RS25225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J43_RS25230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J43_RS25240	COG2409	Drug exporters of the RND superfamily
I6J43_RS25255	COG2197	response regulator
I6J43_RS25265	COG2133	pyrroloquinoline quinone binding
I6J43_RS25270	COG0667	Aldo Keto reductase
I6J43_RS25280	COG3300	MHYT domain
I6J43_RS25280	COG5001	Diguanylate cyclase
I6J43_RS25290	COG0440	acetolactate synthase activity
I6J43_RS25295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J43_RS25300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J43_RS25320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J43_RS25330	COG2508	Transcriptional regulator
I6J43_RS25335	COG0506	proline dehydrogenase activity
I6J43_RS25340	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS25345	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J43_RS25345	COG0778	Nitroreductase
I6J43_RS25360	COG0473	3-isopropylmalate dehydrogenase activity
I6J43_RS25365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J43_RS25375	COG2957	Belongs to the agmatine deiminase family
I6J43_RS25385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J43_RS25390	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J43_RS25400	COG0542	response to heat
I6J43_RS25425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J43_RS25440	COG3708	Transcriptional regulator
I6J43_RS25440	COG2207	Transcriptional regulator
I6J43_RS25460	COG0492	ferredoxin-NADP+ reductase activity
I6J43_RS25505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS25510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS25515	COG1120	ATPase activity
I6J43_RS25520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J43_RS25525	COG2353	YceI-like domain
I6J43_RS25540	COG0366	Alpha amylase catalytic
I6J43_RS25540	COG1470	cell adhesion involved in biofilm formation
I6J43_RS25545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J43_RS25565	COG2018	Roadblock/LC7 domain
I6J43_RS25585	COG2018	Roadblock/LC7 domain
I6J43_RS25590	COG5002	protein histidine kinase activity
I6J43_RS25600	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J43_RS25605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J43_RS25650	COG1414	Transcriptional regulator
I6J43_RS25655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J43_RS25660	COG0066	3-isopropylmalate dehydratase activity
I6J43_RS25670	COG0776	regulation of translation
I6J43_RS25680	COG1920	GTP binding
I6J43_RS25690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J43_RS25695	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J43_RS25715	COG0351	phosphomethylpyrimidine kinase
I6J43_RS25720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J43_RS25725	COG1461	Dihydroxyacetone kinase
I6J43_RS25735	COG0742	ribosomal rna small subunit methyltransferase
I6J43_RS25740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J43_RS25755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J43_RS25760	COG0571	ribonuclease III activity
I6J43_RS25765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J43_RS25770	COG1733	regulation of RNA biosynthetic process
I6J43_RS25780	COG0546	phosphoglycolate phosphatase activity
I6J43_RS25815	COG2340	Cysteine-rich secretory protein family
I6J43_RS25820	COG1254	Belongs to the acylphosphatase family
I6J43_RS25830	COG1196	nuclear chromosome segregation
I6J43_RS25835	COG0477	Major facilitator Superfamily
I6J43_RS25870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J43_RS25890	COG0228	four-way junction DNA binding
I6J43_RS25895	COG1837	Belongs to the UPF0109 family
I6J43_RS25900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J43_RS25905	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J43_RS25910	COG0335	large ribosomal subunit rRNA binding
I6J43_RS25925	COG0681	Belongs to the peptidase S26 family
I6J43_RS25935	COG1051	belongs to the nudix hydrolase family
I6J43_RS25945	COG0792	nuclease activity
I6J43_RS26010	COG1191	sigma factor activity
I6J43_RS26025	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J43_RS26030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J43_RS26035	COG0528	UMP kinase activity
I6J43_RS26040	COG0233	cytoplasmic translational termination
I6J43_RS26045	COG0575	Belongs to the CDS family
I6J43_RS26130	COG2226	methyltransferase
I6J43_RS26135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J43_RS26150	COG3842	ATPase activity
I6J43_RS26165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J43_RS26175	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS26200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J43_RS26240	COG1595	DNA-templated transcription, initiation
I6J43_RS26270	COG3842	ATPase activity
I6J43_RS26275	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J43_RS26280	COG1177	transmembrane transport
I6J43_RS26285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J43_RS26315	COG2508	Transcriptional regulator
I6J43_RS26325	COG2814	Major facilitator Superfamily
I6J43_RS26330	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS26340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J43_RS26345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J43_RS26350	COG0750	zinc metalloprotease
I6J43_RS26355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J43_RS26370	COG0442	prolyl-tRNA aminoacylation
I6J43_RS26390	COG0779	Required for maturation of 30S ribosomal subunits
I6J43_RS26405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J43_RS26415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J43_RS26420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J43_RS26455	COG4608	Belongs to the ABC transporter superfamily
I6J43_RS26465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS26470	COG0601	transmembrane transport
I6J43_RS26475	COG0747	negative chemotaxis
I6J43_RS26480	COG0455	bacterial-type flagellum organization
I6J43_RS26505	COG1404	Belongs to the peptidase S8 family
I6J43_RS26520	COG1404	Belongs to the peptidase S8 family
I6J43_RS26535	COG1674	ftsk spoiiie
I6J43_RS26545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J43_RS26550	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J43_RS26555	COG0612	Peptidase, M16
I6J43_RS26560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J43_RS26580	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6J43_RS26585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J43_RS26590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J43_RS26620	COG2205	protein histidine kinase activity
I6J43_RS26620	COG3437	response regulator, receiver
I6J43_RS26620	COG4999	Histidine kinase
I6J43_RS26620	COG3850	Histidine kinase
I6J43_RS26630	COG1674	ftsk spoiiie
I6J43_RS26640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J43_RS26650	COG1546	Belongs to the CinA family
I6J43_RS26650	COG1058	Belongs to the CinA family
I6J43_RS26655	COG1396	sequence-specific DNA binding
I6J43_RS26660	COG0783	Belongs to the Dps family
I6J43_RS26670	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS26675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J43_RS26680	COG1201	RNA secondary structure unwinding
I6J43_RS26685	COG1917	Cupin 2, conserved barrel domain protein
I6J43_RS26685	COG2207	Transcriptional regulator
I6J43_RS26715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J43_RS26745	COG0765	amino acid transport
I6J43_RS26750	COG0765	amino acid transport
I6J43_RS26755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS26760	COG1126	abc transporter atp-binding protein
I6J43_RS26770	COG2205	protein histidine kinase activity
I6J43_RS26775	COG2358	TRAP transporter, solute receptor (TAXI family
I6J43_RS26780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J43_RS26795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J43_RS26805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J43_RS26810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J43_RS26820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J43_RS26860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J43_RS26865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J43_RS26870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J43_RS26900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J43_RS26935	COG2186	Transcriptional regulator
I6J43_RS26940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J43_RS26965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J43_RS26970	COG4565	transcriptional regulatory protein
I6J43_RS26975	COG3290	protein histidine kinase activity
I6J43_RS26980	COG0372	Belongs to the citrate synthase family
I6J43_RS26985	COG0372	Belongs to the citrate synthase family
I6J43_RS26995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J43_RS27000	COG0612	Peptidase, M16
I6J43_RS27015	COG1802	Transcriptional regulator
I6J43_RS27020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J43_RS27025	COG1042	CoA-binding domain protein
I6J43_RS27025	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J43_RS27025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J43_RS27040	COG1435	thymidine kinase activity
I6J43_RS27080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J43_RS27095	COG0745	RESPONSE REGULATOR receiver
I6J43_RS27100	COG2205	protein histidine kinase activity
I6J43_RS27125	COG0756	dUTP diphosphatase activity
I6J43_RS27135	COG1136	(ABC) transporter
I6J43_RS27135	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J43_RS27165	COG0569	domain protein
I6J43_RS27170	COG0531	amino acid
I6J43_RS27175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J43_RS27205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J43_RS27210	COG4552	Acetyltransferase involved in intracellular survival and related
I6J43_RS27230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J43_RS27250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS27275	COG2814	Major facilitator Superfamily
I6J43_RS27290	COG0596	Alpha beta hydrolase
I6J43_RS27300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J43_RS27310	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J43_RS27320	COG3938	Belongs to the proline racemase family
I6J43_RS27330	COG2423	ornithine cyclodeaminase activity
I6J43_RS27335	COG1802	Transcriptional regulator
I6J43_RS27340	COG0006	proline dipeptidase activity
I6J43_RS27350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS27355	COG0601	transmembrane transport
I6J43_RS27370	COG3291	Pkd domain containing protein
I6J43_RS27380	COG1280	lysine exporter protein (LysE YggA)
I6J43_RS27385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J43_RS27390	COG3046	protein related to deoxyribodipyrimidine photolyase
I6J43_RS27420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS27425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS27435	COG0586	Pfam SNARE associated Golgi protein
I6J43_RS27440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J43_RS27445	COG1349	DNA-binding transcription factor activity
I6J43_RS27450	COG1799	cell septum assembly
I6J43_RS27470	COG2040	homocysteine
I6J43_RS27480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J43_RS27490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J43_RS27495	COG0531	amino acid
I6J43_RS27505	COG1024	Enoyl-CoA hydratase
I6J43_RS27545	COG2111	Na H antiporter
I6J43_RS27545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J43_RS27550	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J43_RS27555	COG0651	ATP synthesis coupled electron transport
I6J43_RS27570	COG1320	monovalent cation:proton antiporter activity
I6J43_RS27585	COG0297	glycogen (starch) synthase activity
I6J43_RS27590	COG0489	protein tyrosine kinase activity
I6J43_RS27625	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J43_RS27630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J43_RS27635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J43_RS27650	COG2197	response regulator
I6J43_RS27670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J43_RS27710	COG0477	Major facilitator Superfamily
I6J43_RS27715	COG3903	Transcriptional regulator
I6J43_RS27715	COG3629	intracellular signal transduction
I6J43_RS27730	COG0300	oxidoreductase activity
I6J43_RS27740	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS27765	COG0475	glutathione-regulated potassium exporter activity
I6J43_RS27785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS27800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J43_RS27830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J43_RS27835	COG0494	nUDIX hydrolase
I6J43_RS27855	COG0588	phosphoglycerate mutase activity
I6J43_RS27865	COG1653	transport
I6J43_RS27870	COG1175	transmembrane transport
I6J43_RS27875	COG0395	ABC-type sugar transport system, permease component
I6J43_RS27880	COG1940	carbohydrate kinase activity
I6J43_RS27885	COG4213	ABC transporter substrate-binding protein
I6J43_RS27895	COG4214	carbohydrate transport
I6J43_RS27900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J43_RS27905	COG0531	amino acid
I6J43_RS27930	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS27945	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS27945	COG1024	Enoyl-CoA hydratase
I6J43_RS27950	COG0183	Belongs to the thiolase family
I6J43_RS27975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J43_RS27990	COG0745	RESPONSE REGULATOR receiver
I6J43_RS27995	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J43_RS28005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J43_RS28010	COG3253	May function as heme-dependent peroxidase
I6J43_RS28025	COG3220	belongs to the UPF0276 family
I6J43_RS28040	COG4152	abc transporter atp-binding protein
I6J43_RS28060	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J43_RS28110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J43_RS28115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J43_RS28220	COG1063	alcohol dehydrogenase
I6J43_RS28225	COG0156	8-amino-7-oxononanoate synthase activity
I6J43_RS28230	COG0583	DNA-binding transcription factor activity
I6J43_RS28240	COG0346	lactoylglutathione lyase activity
I6J43_RS28245	COG1072	(Pantothenic acid kinase))
I6J43_RS28265	COG2723	6-phospho-beta-galactosidase activity
I6J43_RS28320	COG1175	transmembrane transport
I6J43_RS28340	COG1404	Belongs to the peptidase S8 family
I6J43_RS28360	COG1132	(ABC) transporter
I6J43_RS28365	COG1132	(ABC) transporter
I6J43_RS28370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J43_RS28375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS28380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS28385	COG1120	ATPase activity
I6J43_RS28390	COG2226	methyltransferase
I6J43_RS28400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J43_RS28405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J43_RS28425	COG0529	Catalyzes the synthesis of activated sulfate
I6J43_RS28430	COG0175	sulfate reduction
I6J43_RS28465	COG3844	kynureninase activity
I6J43_RS28470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J43_RS28485	COG1917	Cupin 2, conserved barrel domain protein
I6J43_RS28510	COG0583	DNA-binding transcription factor activity
I6J43_RS28515	COG2814	Major facilitator Superfamily
I6J43_RS28535	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS28540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J43_RS28545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J43_RS28550	COG0583	DNA-binding transcription factor activity
I6J43_RS28555	COG0183	Belongs to the thiolase family
I6J43_RS28605	COG1162	GTPase activity
I6J43_RS28625	COG1404	Belongs to the peptidase S8 family
I6J43_RS28635	COG0028	Belongs to the TPP enzyme family
I6J43_RS28655	COG1802	Transcriptional regulator
I6J43_RS28680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J43_RS28685	COG2252	PERMEase
I6J43_RS28690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J43_RS28690	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J43_RS28715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS28745	COG0435	Glutathione S-transferase
I6J43_RS28760	COG2197	response regulator
I6J43_RS28765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J43_RS28770	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS28790	COG3960	tartronate-semialdehyde synthase activity
I6J43_RS28815	COG0753	catalase activity
I6J43_RS28820	COG2084	Dehydrogenase
I6J43_RS28825	COG3622	Belongs to the hyi family
I6J43_RS28830	COG2706	6-phosphogluconolactonase activity
I6J43_RS28850	COG2351	hydroxyisourate hydrolase activity
I6J43_RS28860	COG2233	PERMEase
I6J43_RS28870	COG2233	PERMEase
I6J43_RS28895	COG1288	antiporter activity
I6J43_RS28925	COG0242	peptide deformylase activity
I6J43_RS28930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J43_RS28945	COG2197	response regulator
I6J43_RS28965	COG1414	Transcriptional regulator
I6J43_RS28970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J43_RS28975	COG4266	Belongs to the allantoicase family
I6J43_RS28985	COG0656	L-ascorbic acid biosynthetic process
I6J43_RS28990	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS29010	COG2197	response regulator
I6J43_RS29025	COG0673	inositol 2-dehydrogenase activity
I6J43_RS29030	COG2188	Transcriptional regulator
I6J43_RS29045	COG1129	ABC transporter
I6J43_RS29050	COG1940	carbohydrate kinase activity
I6J43_RS29060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J43_RS29065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J43_RS29100	COG1126	abc transporter atp-binding protein
I6J43_RS29105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J43_RS29110	COG0765	amino acid transport
I6J43_RS29115	COG0765	amino acid transport
I6J43_RS29130	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS29130	COG1024	Enoyl-CoA hydratase
I6J43_RS29135	COG0183	Belongs to the thiolase family
I6J43_RS29145	COG0405	Gamma-glutamyltransferase
I6J43_RS29180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J43_RS29270	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS29290	COG0463	Glycosyl transferase, family 2
I6J43_RS29300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J43_RS29315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS29330	COG0175	sulfate reduction
I6J43_RS29335	COG2895	sulfate adenylyltransferase (ATP) activity
I6J43_RS29380	COG0626	cystathionine gamma-synthase activity
I6J43_RS29395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS29450	COG0095	Lipoate-protein ligase
I6J43_RS29470	COG1024	Enoyl-CoA hydratase
I6J43_RS29475	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS29495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J43_RS29510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J43_RS29555	COG1024	Enoyl-CoA hydratase
I6J43_RS29560	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS29590	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS29595	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS29600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J43_RS29605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J43_RS29615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS29625	COG1131	(ABC) transporter
I6J43_RS29630	COG1024	Enoyl-CoA hydratase
I6J43_RS29640	COG0483	inositol monophosphate 1-phosphatase activity
I6J43_RS29665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J43_RS29695	COG1929	Belongs to the glycerate kinase type-1 family
I6J43_RS29730	COG0688	phosphatidylethanolamine metabolic process
I6J43_RS29735	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS29745	COG2301	Belongs to the HpcH HpaI aldolase family
I6J43_RS29750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J43_RS29750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J43_RS29755	COG0604	alcohol dehydrogenase
I6J43_RS29775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS29785	COG0596	Alpha beta hydrolase
I6J43_RS29815	COG0583	DNA-binding transcription factor activity
I6J43_RS29820	COG0667	Aldo Keto reductase
I6J43_RS29840	COG2362	D-Aminopeptidase
I6J43_RS29845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J43_RS29855	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J43_RS29910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J43_RS29925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J43_RS29925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J43_RS29935	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J43_RS29945	COG0702	epimerase
I6J43_RS29955	COG4106	trans-aconitate 2-methyltransferase activity
I6J43_RS29960	COG0300	oxidoreductase activity
I6J43_RS29990	COG0656	L-ascorbic acid biosynthetic process
I6J43_RS30005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J43_RS30010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J43_RS30020	COG1129	ABC transporter
I6J43_RS30025	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J43_RS30030	COG1879	ABC-type sugar transport system periplasmic component
I6J43_RS30035	COG0673	inositol 2-dehydrogenase activity
I6J43_RS30055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J43_RS30070	COG0084	hydrolase, TatD family'
I6J43_RS30150	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS30150	COG0300	oxidoreductase activity
I6J43_RS30150	COG3321	synthase
I6J43_RS30150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS30150	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS30155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J43_RS30170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS30175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS30180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J43_RS30180	COG3321	synthase
I6J43_RS30180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS30200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS30210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS30235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J43_RS30240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS30245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J43_RS30250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J43_RS30255	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS30275	COG0477	Major facilitator Superfamily
I6J43_RS30280	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS30290	COG1129	ABC transporter
I6J43_RS30295	COG1879	ABC-type sugar transport system periplasmic component
I6J43_RS30300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J43_RS30305	COG1869	D-ribose catabolic process
I6J43_RS30315	COG0714	Associated with various cellular activities
I6J43_RS30330	COG3568	Endonuclease Exonuclease Phosphatase
I6J43_RS30345	COG5002	protein histidine kinase activity
I6J43_RS30350	COG0745	RESPONSE REGULATOR receiver
I6J43_RS30380	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS30390	COG4175	Glycine betaine
I6J43_RS30390	COG0517	IMP dehydrogenase activity
I6J43_RS30395	COG4176	ABC-type proline glycine betaine transport system permease component
I6J43_RS30435	COG0488	(ABC) transporter
I6J43_RS30445	COG1070	Carbohydrate kinase
I6J43_RS30455	COG1940	carbohydrate kinase activity
I6J43_RS30505	COG2124	cytochrome p450
I6J43_RS30510	COG1486	melibiose metabolic process
I6J43_RS30540	COG3012	SEC-C Motif Domain Protein
I6J43_RS30565	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS30610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J43_RS30635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J43_RS30675	COG2326	polyphosphate kinase activity
I6J43_RS30680	COG1793	dna ligase
I6J43_RS30730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J43_RS30745	COG0488	(ABC) transporter
I6J43_RS30770	COG1515	deoxyribonuclease V activity
I6J43_RS30780	COG3268	Saccharopine dehydrogenase
I6J43_RS30785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J43_RS30790	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS30795	COG0183	Belongs to the thiolase family
I6J43_RS30800	COG1024	Enoyl-CoA hydratase
I6J43_RS30800	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS30805	COG0789	Transcriptional regulator
I6J43_RS30830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J43_RS30845	COG0488	(ABC) transporter
I6J43_RS30865	COG4977	sequence-specific DNA binding
I6J43_RS30875	COG1024	Enoyl-CoA hydratase
I6J43_RS30890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J43_RS30920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J43_RS30940	COG1134	teichoic acid transport
I6J43_RS30945	COG1562	ergosterol biosynthetic process
I6J43_RS30955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J43_RS30965	COG1657	PFAM Prenyltransferase squalene oxidase
I6J43_RS31005	COG2755	lipolytic protein G-D-S-L family
I6J43_RS31015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J43_RS31055	COG3467	pyridoxamine 5'-phosphate
I6J43_RS31065	COG0789	Transcriptional regulator
I6J43_RS31120	COG3958	Transketolase
I6J43_RS31125	COG3959	Transketolase, thiamine diphosphate binding domain
I6J43_RS31135	COG0318	PFAM AMP-dependent synthetase and ligase
I6J43_RS31145	COG1733	regulation of RNA biosynthetic process
I6J43_RS31155	COG0789	Transcriptional regulator
I6J43_RS31170	COG3511	phospholipase C
I6J43_RS31180	COG2197	response regulator
I6J43_RS31185	COG3851	Histidine kinase
I6J43_RS31220	COG2197	response regulator
I6J43_RS31255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J43_RS31260	COG2423	ornithine cyclodeaminase activity
I6J43_RS31265	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS31270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS31305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J43_RS31320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS31345	COG1280	lysine exporter protein (LysE YggA)
I6J43_RS31400	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J43_RS31400	COG1902	pentaerythritol trinitrate reductase activity
I6J43_RS31410	COG2409	Drug exporters of the RND superfamily
I6J43_RS31415	COG1846	Transcriptional regulator
I6J43_RS31465	COG2130	NADP-dependent
I6J43_RS31475	COG4948	Mandelate Racemase Muconate Lactonizing
I6J43_RS31480	COG0395	ABC-type sugar transport system, permease component
I6J43_RS31485	COG1175	transmembrane transport
I6J43_RS31500	COG2226	methyltransferase
I6J43_RS31520	COG3647	Membrane
I6J43_RS31525	COG2188	Transcriptional regulator
I6J43_RS31530	COG1742	UPF0060 membrane protein
I6J43_RS31545	COG1794	racemase activity, acting on amino acids and derivatives
I6J43_RS31575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J43_RS31585	COG0019	diaminopimelate decarboxylase activity
I6J43_RS31590	COG2837	iron assimilation
I6J43_RS31595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J43_RS31610	COG1119	ATPase activity
I6J43_RS31620	COG1595	DNA-templated transcription, initiation
I6J43_RS31650	COG0596	Alpha beta hydrolase
I6J43_RS31660	COG1028	Short-chain dehydrogenase reductase Sdr
I6J43_RS31670	COG1652	LysM domain
I6J43_RS31695	COG2208	phosphoserine phosphatase activity
I6J43_RS31705	COG0784	Response regulator, receiver
I6J43_RS31710	COG4251	negative regulation of phosphorylation
I6J43_RS31715	COG2201	protein-glutamate methylesterase activity
I6J43_RS31720	COG1191	sigma factor activity
I6J43_RS31760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J43_RS31775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J43_RS31780	COG3275	phosphorelay sensor kinase activity
I6J43_RS31850	COG0583	DNA-binding transcription factor activity
I6J43_RS31860	COG1053	succinate dehydrogenase
I6J43_RS31865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J43_RS31875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J43_RS31885	COG3360	Dodecin
I6J43_RS31890	COG1653	transport
I6J43_RS31905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J43_RS31910	COG0121	glutamine amidotransferase
I6J43_RS31915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J43_RS31935	COG1609	Transcriptional regulator
I6J43_RS31945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J43_RS31950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J43_RS31970	COG0714	Associated with various cellular activities
I6J43_RS31990	COG1191	sigma factor activity
I6J43_RS32000	COG2045	Belongs to the ComB family
I6J43_RS32005	COG1834	amidinotransferase
I6J43_RS32015	COG1228	amidohydrolase
I6J43_RS32020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J43_RS32035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J43_RS32110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J43_RS32130	COG0463	Glycosyl transferase, family 2
I6J43_RS32195	COG0477	Major facilitator Superfamily
I6J43_RS32205	COG0254	rRNA binding
I6J43_RS32210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J43_RS32215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J43_RS32220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J43_RS32235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS32240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS32245	COG1120	ATPase activity
I6J43_RS32270	COG1132	(ABC) transporter
I6J43_RS32275	COG1132	(ABC) transporter
I6J43_RS32300	COG2304	oxidoreductase activity
I6J43_RS32320	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS32325	COG0726	polysaccharide deacetylase
I6J43_RS32345	COG0438	transferase activity, transferring glycosyl groups
I6J43_RS32345	COG0297	glycogen (starch) synthase activity
I6J43_RS32360	COG1174	glycine betaine transport
I6J43_RS32365	COG1174	glycine betaine transport
I6J43_RS32380	COG1125	glycine betaine transport
I6J43_RS32380	COG0517	IMP dehydrogenase activity
I6J43_RS32410	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS32415	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS32430	COG0601	transmembrane transport
I6J43_RS32435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J43_RS32440	COG0444	Belongs to the ABC transporter superfamily
I6J43_RS32540	COG1796	DNA polymerase
I6J43_RS32540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J43_RS32600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J43_RS32625	COG1278	Cold shock
I6J43_RS32630	COG0477	Major facilitator Superfamily
I6J43_RS32645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J43_RS32670	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J43_RS32690	COG1063	alcohol dehydrogenase
I6J43_RS32710	COG1349	DNA-binding transcription factor activity
I6J43_RS32730	COG0789	Transcriptional regulator
I6J43_RS32735	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS32755	COG1012	belongs to the aldehyde dehydrogenase family
I6J43_RS32765	COG0385	Bile acid
I6J43_RS32810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J43_RS32850	COG0640	Transcriptional regulator
I6J43_RS32865	COG2018	Roadblock/LC7 domain
I6J43_RS32875	COG0456	acetyltransferase
I6J43_RS32890	COG1024	Enoyl-CoA hydratase
I6J43_RS32905	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J43_RS32915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J43_RS32925	COG2340	Cysteine-rich secretory protein family
I6J43_RS32965	COG0488	(ABC) transporter
I6J43_RS32985	COG0009	L-threonylcarbamoyladenylate synthase
I6J43_RS33010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J43_RS33025	COG2318	DinB family
I6J43_RS33035	COG1609	Transcriptional regulator
I6J43_RS33050	COG0395	ABC-type sugar transport system, permease component
I6J43_RS33055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J43_RS33060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS33070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J43_RS33080	COG0714	Associated with various cellular activities
I6J43_RS33085	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J43_RS33115	COG2205	protein histidine kinase activity
I6J43_RS33120	COG0745	RESPONSE REGULATOR receiver
I6J43_RS33135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J43_RS33140	COG1120	ATPase activity
I6J43_RS33155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J43_RS33205	COG0586	Pfam SNARE associated Golgi protein
I6J43_RS33220	COG2226	methyltransferase
I6J43_RS33225	COG0745	RESPONSE REGULATOR receiver
I6J43_RS33230	COG2205	protein histidine kinase activity
I6J43_RS33240	COG1404	Belongs to the peptidase S8 family
I6J43_RS33265	COG1595	DNA-templated transcription, initiation
I6J43_RS33275	COG0831	urea catabolic process
I6J43_RS33280	COG0832	Belongs to the urease beta subunit family
I6J43_RS33290	COG0830	nickel cation binding
I6J43_RS33295	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J43_RS33300	COG0829	nickel cation binding
I6J43_RS33310	COG4214	carbohydrate transport
I6J43_RS33320	COG4213	ABC transporter substrate-binding protein
I6J43_RS33330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J43_RS33335	COG0406	alpha-ribazole phosphatase activity
I6J43_RS33345	COG1070	Carbohydrate kinase
I6J43_RS33400	COG0395	ABC-type sugar transport system, permease component
I6J43_RS33425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J43_RS33450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J43_RS33475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J43_RS33495	COG0312	modulator of DNA gyrase
I6J43_RS33520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J43_RS33895	COG4264	IucA IucC family
I6J43_RS33905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6J43_RS33930	COG0720	synthase
I6J43_RS33945	COG0302	gtp cyclohydrolase
I6J43_RS33960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J43_RS33990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J43_RS33995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J43_RS34030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J43_RS34040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J43_RS34060	COG1960	acyl-CoA dehydrogenase activity
I6J43_RS34090	COG1132	(ABC) transporter
I6J43_RS34095	COG2226	methyltransferase
I6J43_RS34155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J43_RS34160	COG1518	maintenance of DNA repeat elements
I6J43_RS34215	COG1725	Transcriptional regulator
I6J43_RS34280	COG1674	ftsk spoiiie
I6J43_RS34285	COG4974	Belongs to the 'phage' integrase family
I6J43_RS34400	COG1192	Involved in chromosome partitioning
I6J43_RS34440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J43_RS34455	COG0587	DNA-directed DNA polymerase activity
I6J43_RS34485	COG0492	ferredoxin-NADP+ reductase activity
I6J43_RS34490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J43_RS34500	COG0798	PFAM Bile acid sodium symporter
I6J43_RS34510	COG2072	flavoprotein involved in K transport
I6J43_RS34535	COG0640	Transcriptional regulator
I6J43_RS34560	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J43_RS34625	COG3328	transposase activity