locus-tag	class	description
CVT27_RS00040	COG0367	asparagine synthase
CVT27_RS00045	COG0477	Major facilitator Superfamily
CVT27_RS00050	COG2050	protein possibly involved in aromatic compounds catabolism
CVT27_RS00060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVT27_RS00065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS00075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS00080	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS00150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CVT27_RS00155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVT27_RS00165	COG1846	Transcriptional regulator
CVT27_RS00170	COG1764	response to oxidative stress
CVT27_RS00180	COG0789	Transcriptional regulator
CVT27_RS00205	COG0277	FAD linked oxidase domain protein
CVT27_RS00215	COG1902	pentaerythritol trinitrate reductase activity
CVT27_RS00220	COG0640	Transcriptional regulator
CVT27_RS00225	COG1064	alcohol dehydrogenase
CVT27_RS00250	COG0702	epimerase
CVT27_RS00280	COG0642	Histidine kinase
CVT27_RS00300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVT27_RS00305	COG0366	Alpha amylase catalytic
CVT27_RS00310	COG0395	ABC-type sugar transport system, permease component
CVT27_RS00315	COG1175	transmembrane transport
CVT27_RS00360	COG1349	DNA-binding transcription factor activity
CVT27_RS00365	COG1105	Belongs to the carbohydrate kinase PfkB family
CVT27_RS00440	COG0254	rRNA binding
CVT27_RS00500	COG1024	Enoyl-CoA hydratase
CVT27_RS00525	COG0765	amino acid transport
CVT27_RS00535	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS00540	COG2366	antibiotic biosynthetic process
CVT27_RS00550	COG2070	2-Nitropropane dioxygenase
CVT27_RS00555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CVT27_RS00565	COG0515	serine threonine protein kinase
CVT27_RS00580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVT27_RS00585	COG0346	lactoylglutathione lyase activity
CVT27_RS00600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS00610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS00610	COG3321	synthase
CVT27_RS00610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS00610	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CVT27_RS00610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVT27_RS00610	COG3321	synthase
CVT27_RS00610	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CVT27_RS00610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVT27_RS00615	COG0300	oxidoreductase activity
CVT27_RS00615	COG3321	synthase
CVT27_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS00615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS00615	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS00620	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS00625	COG2813	Specifically methylates the guanine in position
CVT27_RS00640	COG2356	endonuclease I
CVT27_RS00645	COG2066	Belongs to the glutaminase family
CVT27_RS00645	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CVT27_RS00660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVT27_RS00665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CVT27_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS00680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVT27_RS00685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVT27_RS00690	COG2080	2 iron, 2 sulfur cluster binding
CVT27_RS00750	COG2365	Tyrosine phosphatase family
CVT27_RS00775	COG1120	ATPase activity
CVT27_RS00780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVT27_RS00790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS00800	COG0477	Major facilitator Superfamily
CVT27_RS00805	COG2382	esterase
CVT27_RS00810	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS00820	COG1169	isochorismate synthase
CVT27_RS00825	COG1021	2,3-dihydroxybenzoate-AMP ligase
CVT27_RS00830	COG3433	isochorismatase activity
CVT27_RS00830	COG1535	isochorismatase
CVT27_RS00835	COG3433	isochorismatase activity
CVT27_RS00835	COG1535	isochorismatase
CVT27_RS00855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVT27_RS00890	COG3845	ABC transporter
CVT27_RS00915	COG1470	cell adhesion involved in biofilm formation
CVT27_RS00950	COG1063	alcohol dehydrogenase
CVT27_RS00955	COG0395	ABC-type sugar transport system, permease component
CVT27_RS00970	COG1349	DNA-binding transcription factor activity
CVT27_RS01000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CVT27_RS01020	COG2382	esterase
CVT27_RS01025	COG1132	(ABC) transporter
CVT27_RS01035	COG1132	(ABC) transporter
CVT27_RS01045	COG1120	ATPase activity
CVT27_RS01050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS01060	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CVT27_RS01080	COG3842	ATPase activity
CVT27_RS01115	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVT27_RS01115	COG1902	pentaerythritol trinitrate reductase activity
CVT27_RS01125	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS01130	COG1309	transcriptional regulator
CVT27_RS01135	COG0640	Transcriptional regulator
CVT27_RS01170	COG1132	(ABC) transporter
CVT27_RS01175	COG1132	(ABC) transporter
CVT27_RS01180	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVT27_RS01195	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVT27_RS01215	COG0504	CTP synthase activity
CVT27_RS01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CVT27_RS01225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVT27_RS01230	COG2197	response regulator
CVT27_RS01235	COG0640	Transcriptional regulator
CVT27_RS01240	COG0243	molybdopterin cofactor binding
CVT27_RS01265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVT27_RS01270	COG0573	inorganic phosphate transmembrane transporter activity
CVT27_RS01275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CVT27_RS01280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVT27_RS01285	COG0798	PFAM Bile acid sodium symporter
CVT27_RS01295	COG2226	methyltransferase
CVT27_RS01305	COG0583	DNA-binding transcription factor activity
CVT27_RS01310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVT27_RS01320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVT27_RS01330	COG1116	anion transmembrane transporter activity
CVT27_RS01350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CVT27_RS01370	COG0640	Transcriptional regulator
CVT27_RS01395	COG1191	sigma factor activity
CVT27_RS01430	COG0297	glycogen (starch) synthase activity
CVT27_RS01450	COG0531	amino acid
CVT27_RS01465	COG1982	Orn Lys Arg decarboxylase major
CVT27_RS01505	COG2376	Dihydroxyacetone kinase
CVT27_RS01510	COG1461	Dihydroxyacetone kinase
CVT27_RS01525	COG0488	(ABC) transporter
CVT27_RS01555	COG1191	sigma factor activity
CVT27_RS01565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVT27_RS01585	COG1120	ATPase activity
CVT27_RS01590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS01615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS01660	COG1063	alcohol dehydrogenase
CVT27_RS01665	COG1959	2 iron, 2 sulfur cluster binding
CVT27_RS01665	COG1295	ribonuclease BN
CVT27_RS01695	COG2837	iron assimilation
CVT27_RS01700	COG1120	ATPase activity
CVT27_RS01705	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS01710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS01730	COG0617	tRNA 3'-terminal CCA addition
CVT27_RS01735	COG2207	Transcriptional regulator
CVT27_RS01750	COG1874	Beta-galactosidase
CVT27_RS01750	COG0366	Alpha amylase catalytic
CVT27_RS01765	COG1609	Transcriptional regulator
CVT27_RS01770	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS01780	COG1129	ABC transporter
CVT27_RS01785	COG1879	ABC-type sugar transport system periplasmic component
CVT27_RS01790	COG3250	beta-galactosidase activity
CVT27_RS01835	COG0328	RNA-DNA hybrid ribonuclease activity
CVT27_RS01840	COG1132	(ABC) transporter
CVT27_RS01850	COG2264	protein methyltransferase activity
CVT27_RS01900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVT27_RS01955	COG2045	Belongs to the ComB family
CVT27_RS01975	COG0464	growth
CVT27_RS01985	COG1349	DNA-binding transcription factor activity
CVT27_RS02000	COG0702	epimerase
CVT27_RS02040	COG1940	carbohydrate kinase activity
CVT27_RS02045	COG2223	nitrite transmembrane transporter activity
CVT27_RS02085	COG0445	tRNA wobble uridine modification
CVT27_RS02100	COG1660	Displays ATPase and GTPase activities
CVT27_RS02105	COG1940	carbohydrate kinase activity
CVT27_RS02125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVT27_RS02170	COG0584	glycerophosphoryl diester phosphodiesterase
CVT27_RS02175	COG0456	acetyltransferase
CVT27_RS02190	COG0671	phosphoesterase, PA-phosphatase related
CVT27_RS02240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVT27_RS02245	COG2971	BadF BadG BcrA BcrD
CVT27_RS02255	COG2706	6-phosphogluconolactonase activity
CVT27_RS02275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS02280	COG0515	serine threonine protein kinase
CVT27_RS02280	COG2815	serine threonine protein kinase
CVT27_RS02285	COG0667	Aldo Keto reductase
CVT27_RS02315	COG1253	flavin adenine dinucleotide binding
CVT27_RS02355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CVT27_RS02360	COG0531	amino acid
CVT27_RS02365	COG2186	Transcriptional regulator
CVT27_RS02370	COG0174	glutamine synthetase
CVT27_RS02375	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS02385	COG1609	Transcriptional regulator
CVT27_RS02390	COG1653	transport
CVT27_RS02395	COG1175	transmembrane transport
CVT27_RS02405	COG1472	Belongs to the glycosyl hydrolase 3 family
CVT27_RS02435	COG4981	capsule polysaccharide biosynthetic process
CVT27_RS02455	COG2835	tetraacyldisaccharide 4'-kinase activity
CVT27_RS02465	COG0745	RESPONSE REGULATOR receiver
CVT27_RS02480	COG0243	molybdopterin cofactor binding
CVT27_RS02505	COG1357	PFAM Pentapeptide repeats (8 copies)
CVT27_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS02515	COG1982	Orn Lys Arg decarboxylase major
CVT27_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS02585	COG2124	cytochrome p450
CVT27_RS02600	COG1335	isochorismatase
CVT27_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS02660	COG0542	response to heat
CVT27_RS02675	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS02680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS02690	COG4592	Periplasmic binding protein
CVT27_RS02720	COG0385	Bile acid
CVT27_RS02745	COG0583	DNA-binding transcription factor activity
CVT27_RS02765	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CVT27_RS02785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVT27_RS02790	COG1116	anion transmembrane transporter activity
CVT27_RS02800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS02805	COG2072	flavoprotein involved in K transport
CVT27_RS02820	COG1132	(ABC) transporter
CVT27_RS02830	COG0277	FAD linked oxidase domain protein
CVT27_RS02840	COG1132	(ABC) transporter
CVT27_RS02845	COG1132	(ABC) transporter
CVT27_RS02870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVT27_RS02870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVT27_RS02885	COG1252	NADH dehydrogenase
CVT27_RS02890	COG1793	dna ligase
CVT27_RS02905	COG1946	Acyl-CoA thioesterase
CVT27_RS02920	COG0386	Belongs to the glutathione peroxidase family
CVT27_RS02925	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS02935	COG0242	peptide deformylase activity
CVT27_RS02945	COG3442	glutamine amidotransferase
CVT27_RS02950	COG0205	6-phosphofructokinase activity
CVT27_RS02980	COG0829	nickel cation binding
CVT27_RS02985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVT27_RS02995	COG0804	urea catabolic process
CVT27_RS03000	COG0832	Belongs to the urease beta subunit family
CVT27_RS03005	COG0831	urea catabolic process
CVT27_RS03050	COG0156	8-amino-7-oxononanoate synthase activity
CVT27_RS03055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVT27_RS03060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVT27_RS03065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVT27_RS03070	COG2226	methyltransferase
CVT27_RS03095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVT27_RS03100	COG3663	DNA glycosylase
CVT27_RS03110	COG1940	carbohydrate kinase activity
CVT27_RS03115	COG2188	Transcriptional regulator
CVT27_RS03120	COG1595	DNA-templated transcription, initiation
CVT27_RS03150	COG0626	cystathionine gamma-synthase activity
CVT27_RS03170	COG1522	sequence-specific DNA binding
CVT27_RS03175	COG0419	ATPase involved in DNA repair
CVT27_RS03180	COG0420	3'-5' exonuclease activity
CVT27_RS03185	COG1739	Uncharacterized protein family UPF0029
CVT27_RS03190	COG1832	CoA-binding protein
CVT27_RS03230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVT27_RS03245	COG1968	undecaprenyl-diphosphatase activity
CVT27_RS03255	COG2226	methyltransferase
CVT27_RS03260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVT27_RS03310	COG2318	DinB family
CVT27_RS03325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVT27_RS03370	COG2188	Transcriptional regulator
CVT27_RS03390	COG0583	DNA-binding transcription factor activity
CVT27_RS03420	COG0697	spore germination
CVT27_RS03505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVT27_RS03505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVT27_RS03515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVT27_RS03535	COG1716	ATPase activity
CVT27_RS03555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVT27_RS03590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVT27_RS03600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVT27_RS03615	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CVT27_RS03645	COG2018	Roadblock/LC7 domain
CVT27_RS03720	COG2364	Membrane
CVT27_RS03730	COG2270	Major facilitator Superfamily
CVT27_RS03740	COG3030	protein affecting phage T7 exclusion by the F plasmid
CVT27_RS03745	COG1216	Glycosyl transferase, family 2
CVT27_RS03770	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS03815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVT27_RS03820	COG0140	phosphoribosyl-ATP diphosphatase activity
CVT27_RS03825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVT27_RS03835	COG3201	nicotinamide mononucleotide transporter
CVT27_RS03860	COG0738	Major facilitator superfamily
CVT27_RS03865	COG2233	PERMEase
CVT27_RS03880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVT27_RS03890	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS03905	COG2390	Transcriptional regulator
CVT27_RS03910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVT27_RS03920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVT27_RS03935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVT27_RS03945	COG1758	RNA polymerase activity
CVT27_RS03960	COG0284	orotidine-5'-phosphate decarboxylase activity
CVT27_RS03965	COG0167	dihydroorotate dehydrogenase activity
CVT27_RS03970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVT27_RS03975	COG0505	Belongs to the CarA family
CVT27_RS03985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVT27_RS03990	COG0540	Belongs to the ATCase OTCase family
CVT27_RS03995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CVT27_RS04005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVT27_RS04010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVT27_RS04015	COG0006	proline dipeptidase activity
CVT27_RS04025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVT27_RS04030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVT27_RS04035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVT27_RS04040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVT27_RS04055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVT27_RS04060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVT27_RS04080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVT27_RS04100	COG0124	histidyl-tRNA synthetase
CVT27_RS04115	COG1196	nuclear chromosome segregation
CVT27_RS04120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVT27_RS04125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVT27_RS04130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVT27_RS04135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVT27_RS04145	COG2255	four-way junction helicase activity
CVT27_RS04150	COG0632	four-way junction helicase activity
CVT27_RS04155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVT27_RS04160	COG0217	transcriptional regulatory protein
CVT27_RS04165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CVT27_RS04170	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CVT27_RS04180	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS04185	COG1560	Kdo2-lipid A biosynthetic process
CVT27_RS04190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVT27_RS04215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVT27_RS04230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVT27_RS04285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVT27_RS04340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVT27_RS04340	COG1648	precorrin-2 dehydrogenase activity
CVT27_RS04345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CVT27_RS04360	COG1464	Belongs to the NlpA lipoprotein family
CVT27_RS04365	COG2011	ABC-type metal ion transport system permease component
CVT27_RS04405	COG0477	Major facilitator Superfamily
CVT27_RS04415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVT27_RS04420	COG3973	AAA domain
CVT27_RS04430	COG0165	Argininosuccinate lyase
CVT27_RS04435	COG0137	argininosuccinate synthase activity
CVT27_RS04445	COG1438	arginine binding
CVT27_RS04450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVT27_RS04455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVT27_RS04460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CVT27_RS04465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVT27_RS04515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CVT27_RS04530	COG0697	spore germination
CVT27_RS04540	COG1649	PFAM Uncharacterised BCR, COG1649
CVT27_RS04560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVT27_RS04560	COG0072	phenylalanine-tRNA ligase activity
CVT27_RS04565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVT27_RS04570	COG5002	protein histidine kinase activity
CVT27_RS04575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVT27_RS04580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVT27_RS04585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVT27_RS04590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVT27_RS04660	COG4175	Glycine betaine
CVT27_RS04660	COG0517	IMP dehydrogenase activity
CVT27_RS04665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVT27_RS04690	COG1595	DNA-templated transcription, initiation
CVT27_RS04710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVT27_RS04715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVT27_RS04755	COG0805	protein transport
CVT27_RS04760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVT27_RS04780	COG2378	regulation of single-species biofilm formation
CVT27_RS04790	COG0545	Peptidyl-prolyl cis-trans isomerase
CVT27_RS04795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CVT27_RS04805	COG1609	Transcriptional regulator
CVT27_RS04810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CVT27_RS04815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CVT27_RS04830	COG4122	O-methyltransferase activity
CVT27_RS04835	COG1222	aaa ATPase
CVT27_RS04860	COG1994	Peptidase M50
CVT27_RS04860	COG0517	IMP dehydrogenase activity
CVT27_RS04870	COG2197	response regulator
CVT27_RS04875	COG4166	transmembrane transport
CVT27_RS04885	COG0646	methionine synthase
CVT27_RS04885	COG1410	methionine synthase
CVT27_RS04890	COG1414	Transcriptional regulator
CVT27_RS04895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVT27_RS04900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVT27_RS04905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVT27_RS04910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS04920	COG0215	cysteine-tRNA ligase activity
CVT27_RS04940	COG0598	Magnesium transport protein CorA
CVT27_RS04950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS04955	COG0667	Aldo Keto reductase
CVT27_RS04985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVT27_RS04995	COG0564	pseudouridine synthase activity
CVT27_RS05010	COG2186	Transcriptional regulator
CVT27_RS05015	COG3265	gluconokinase activity
CVT27_RS05045	COG3573	Dehydrogenase
CVT27_RS05050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CVT27_RS05055	COG2149	membrane
CVT27_RS05075	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS05080	COG2234	aminopeptidase activity
CVT27_RS05080	COG4935	Belongs to the peptidase S8 family
CVT27_RS05090	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS05100	COG3876	Protein conserved in bacteria
CVT27_RS05120	COG0789	Transcriptional regulator
CVT27_RS05140	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS05150	COG2326	polyphosphate kinase activity
CVT27_RS05170	COG2851	Citrate transporter
CVT27_RS05175	COG0243	molybdopterin cofactor binding
CVT27_RS05180	COG1309	transcriptional regulator
CVT27_RS05185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVT27_RS05190	COG2188	Transcriptional regulator
CVT27_RS05200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVT27_RS05210	COG2755	lipolytic protein G-D-S-L family
CVT27_RS05220	COG1725	Transcriptional regulator
CVT27_RS05235	COG0346	lactoylglutathione lyase activity
CVT27_RS05255	COG4565	transcriptional regulatory protein
CVT27_RS05275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVT27_RS05280	COG0587	DNA-directed DNA polymerase activity
CVT27_RS05310	COG0641	radical SAM
CVT27_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS05350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS05370	COG0765	amino acid transport
CVT27_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS05385	COG1799	cell septum assembly
CVT27_RS05390	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS05395	COG0477	Major facilitator Superfamily
CVT27_RS05400	COG0671	phosphoesterase, PA-phosphatase related
CVT27_RS05420	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS05435	COG1160	GTP binding
CVT27_RS05445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVT27_RS05465	COG3541	Predicted nucleotidyltransferase
CVT27_RS05470	COG3541	Predicted nucleotidyltransferase
CVT27_RS05480	COG0494	nUDIX hydrolase
CVT27_RS05495	COG1187	pseudouridine synthase activity
CVT27_RS05500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVT27_RS05505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CVT27_RS05520	COG0686	Belongs to the AlaDH PNT family
CVT27_RS05530	COG0494	nUDIX hydrolase
CVT27_RS05535	COG0504	CTP synthase activity
CVT27_RS05540	COG3387	PFAM Glycoside hydrolase 15-related
CVT27_RS05555	COG3119	arylsulfatase activity
CVT27_RS05560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVT27_RS05570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS05575	COG0601	transmembrane transport
CVT27_RS05580	COG4166	transmembrane transport
CVT27_RS05610	COG0497	DNA recombination
CVT27_RS05615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVT27_RS05635	COG1120	ATPase activity
CVT27_RS05640	COG0647	UMP catabolic process
CVT27_RS05675	COG2094	Belongs to the DNA glycosylase MPG family
CVT27_RS05685	COG1881	PFAM PEBP family protein
CVT27_RS05710	COG1119	ATPase activity
CVT27_RS05720	COG2197	response regulator
CVT27_RS05735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVT27_RS05745	COG1716	ATPase activity
CVT27_RS05745	COG1131	(ABC) transporter
CVT27_RS05745	COG0842	Transport permease protein
CVT27_RS05750	COG0560	Phosphoserine phosphatase
CVT27_RS05750	COG3830	Belongs to the UPF0237 family
CVT27_RS05770	COG2186	Transcriptional regulator
CVT27_RS05780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVT27_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS05800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVT27_RS05805	COG2261	transglycosylase associated protein
CVT27_RS05820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVT27_RS05825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVT27_RS05860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVT27_RS05875	COG3387	PFAM Glycoside hydrolase 15-related
CVT27_RS05915	COG1024	Enoyl-CoA hydratase
CVT27_RS05925	COG0488	(ABC) transporter
CVT27_RS05950	COG0235	Class ii aldolase
CVT27_RS05965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CVT27_RS05970	COG1492	cobalamin metabolic process
CVT27_RS05985	COG1797	cobyrinic acid a,c-diamide synthase activity
CVT27_RS06010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVT27_RS06040	COG1902	pentaerythritol trinitrate reductase activity
CVT27_RS06045	COG1846	Transcriptional regulator
CVT27_RS06075	COG0768	penicillin binding
CVT27_RS06080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS06090	COG0431	NADPH-dependent FMN reductase
CVT27_RS06135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVT27_RS06140	COG2171	N-acyltransferase activity
CVT27_RS06160	COG3226	Transcriptional regulator
CVT27_RS06185	COG2151	metal-sulfur cluster biosynthetic enzyme
CVT27_RS06190	COG0822	iron-sulfur transferase activity
CVT27_RS06195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVT27_RS06200	COG0396	ATPase activity
CVT27_RS06210	COG0719	Fe-S assembly protein
CVT27_RS06225	COG1131	(ABC) transporter
CVT27_RS06235	COG1612	heme a metabolic process
CVT27_RS06245	COG0109	protoheme IX farnesyltransferase activity
CVT27_RS06255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVT27_RS06270	COG0363	glucosamine-6-phosphate deaminase activity
CVT27_RS06280	COG4195	phage-related replication protein
CVT27_RS06295	COG0166	Belongs to the GPI family
CVT27_RS06305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVT27_RS06310	COG0149	triose-phosphate isomerase activity
CVT27_RS06315	COG0126	phosphoglycerate kinase activity
CVT27_RS06320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVT27_RS06325	COG1481	regulation of sporulation
CVT27_RS06330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CVT27_RS06335	COG1660	Displays ATPase and GTPase activities
CVT27_RS06340	COG0322	excinuclease ABC activity
CVT27_RS06365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVT27_RS06395	COG0556	nucleotide-excision repair
CVT27_RS06405	COG0584	glycerophosphoryl diester phosphodiesterase
CVT27_RS06410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVT27_RS06415	COG2814	Major facilitator Superfamily
CVT27_RS06425	COG2313	pseudouridylate synthase activity
CVT27_RS06435	COG1473	amidohydrolase
CVT27_RS06455	COG0436	Aminotransferase
CVT27_RS06475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVT27_RS06500	COG0237	dephospho-CoA kinase activity
CVT27_RS06520	COG2226	methyltransferase
CVT27_RS06525	COG1643	Atp-dependent helicase
CVT27_RS06560	COG2050	protein possibly involved in aromatic compounds catabolism
CVT27_RS06615	COG0737	Belongs to the 5'-nucleotidase family
CVT27_RS06635	COG0659	secondary active sulfate transmembrane transporter activity
CVT27_RS06645	COG2824	Alkylphosphonate utilization operon protein PhnA
CVT27_RS06660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVT27_RS06665	COG1605	Chorismate mutase
CVT27_RS06665	COG0287	Prephenate dehydrogenase
CVT27_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS06710	COG1024	Enoyl-CoA hydratase
CVT27_RS06735	COG1278	Cold shock
CVT27_RS06740	COG0183	Belongs to the thiolase family
CVT27_RS06745	COG1309	transcriptional regulator
CVT27_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS06755	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS06760	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS06775	COG2304	oxidoreductase activity
CVT27_RS06780	COG0705	Rhomboid family
CVT27_RS06790	COG0070	glutamate synthase
CVT27_RS06790	COG0069	glutamate synthase activity
CVT27_RS06790	COG0067	glutamate synthase
CVT27_RS06820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVT27_RS06825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVT27_RS06835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CVT27_RS06845	COG0159	tryptophan synthase activity
CVT27_RS06850	COG0133	tryptophan synthase activity
CVT27_RS06860	COG0134	indole-3-glycerol-phosphate synthase activity
CVT27_RS06880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVT27_RS06885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVT27_RS06895	COG2508	Transcriptional regulator
CVT27_RS06910	COG0107	imidazoleglycerol-phosphate synthase activity
CVT27_RS06915	COG0251	oxidation-reduction process
CVT27_RS06920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVT27_RS06925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVT27_RS06930	COG0131	Imidazoleglycerol-phosphate dehydratase
CVT27_RS06935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVT27_RS06940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVT27_RS06955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVT27_RS06980	COG1432	Conserved Protein
CVT27_RS06990	COG0587	DNA-directed DNA polymerase activity
CVT27_RS07040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVT27_RS07055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVT27_RS07060	COG3599	regulation of cell shape
CVT27_RS07070	COG1799	cell septum assembly
CVT27_RS07075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVT27_RS07100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVT27_RS07110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVT27_RS07115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVT27_RS07125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVT27_RS07130	COG0768	penicillin binding
CVT27_RS07140	COG0275	rRNA processing
CVT27_RS07150	COG0714	Associated with various cellular activities
CVT27_RS07170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVT27_RS07180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVT27_RS07185	COG1511	domain protein
CVT27_RS07215	COG0352	thiamine-phosphate diphosphorylase activity
CVT27_RS07235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS07235	COG2022	thiamine diphosphate biosynthetic process
CVT27_RS07245	COG2022	thiamine diphosphate biosynthetic process
CVT27_RS07250	COG2815	serine threonine protein kinase
CVT27_RS07250	COG0515	serine threonine protein kinase
CVT27_RS07255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CVT27_RS07260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVT27_RS07265	COG2193	ferroxidase activity
CVT27_RS07275	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CVT27_RS07290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVT27_RS07300	COG2197	response regulator
CVT27_RS07305	COG4585	Histidine kinase
CVT27_RS07330	COG1940	carbohydrate kinase activity
CVT27_RS07340	COG0003	Pfam Anion-transporting ATPase
CVT27_RS07360	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS07405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVT27_RS07410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVT27_RS07415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVT27_RS07420	COG0723	plastoquinol--plastocyanin reductase activity
CVT27_RS07425	COG2010	Cytochrome c
CVT27_RS07430	COG1845	cytochrome c oxidase, subunit III
CVT27_RS07440	COG1376	ErfK ybiS ycfS ynhG family protein
CVT27_RS07450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVT27_RS07455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVT27_RS07460	COG1104	cysteine desulfurase activity
CVT27_RS07465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVT27_RS07485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVT27_RS07495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVT27_RS07500	COG2197	response regulator
CVT27_RS07505	COG4585	Histidine kinase
CVT27_RS07530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVT27_RS07545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CVT27_RS07565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CVT27_RS07570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVT27_RS07575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVT27_RS07580	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVT27_RS07590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVT27_RS07610	COG1090	epimerase
CVT27_RS07625	COG0321	lipoyl(octanoyl) transferase activity
CVT27_RS07630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVT27_RS07685	COG1846	Transcriptional regulator
CVT27_RS07720	COG0745	RESPONSE REGULATOR receiver
CVT27_RS07730	COG2197	response regulator
CVT27_RS07790	COG0366	Alpha amylase catalytic
CVT27_RS07795	COG3833	ABC-type maltose transport systems, permease component
CVT27_RS07800	COG1175	transmembrane transport
CVT27_RS07810	COG1609	Transcriptional regulator
CVT27_RS07835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVT27_RS07840	COG2890	protein-(glutamine-N5) methyltransferase activity
CVT27_RS07845	COG0456	acetyltransferase
CVT27_RS07845	COG0454	-acetyltransferase
CVT27_RS07925	COG0174	glutamine synthetase
CVT27_RS07940	COG2132	Multicopper oxidase
CVT27_RS07945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVT27_RS07945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVT27_RS07950	COG2814	Major facilitator Superfamily
CVT27_RS07965	COG0477	Major facilitator Superfamily
CVT27_RS07970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVT27_RS07990	COG1994	Peptidase M50
CVT27_RS08025	COG5398	heme oxygenase
CVT27_RS08045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVT27_RS08050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS08055	COG1120	ATPase activity
CVT27_RS08075	COG1834	amidinotransferase
CVT27_RS08095	COG2814	Major facilitator Superfamily
CVT27_RS08105	COG3540	Alkaline phosphatase
CVT27_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS08120	COG0384	phenazine biosynthesis protein PhzF
CVT27_RS08145	COG2273	Hydrolase Family 16
CVT27_RS08175	COG3022	response to hydroperoxide
CVT27_RS08180	COG0800	Aldolase
CVT27_RS08205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVT27_RS08225	COG2030	dehydratase
CVT27_RS08235	COG0183	Belongs to the thiolase family
CVT27_RS08240	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS08245	COG3629	intracellular signal transduction
CVT27_RS08245	COG3903	Transcriptional regulator
CVT27_RS08260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVT27_RS08265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVT27_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS08280	COG0655	NAD(P)H dehydrogenase (quinone) activity
CVT27_RS08315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS08345	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS08350	COG1309	transcriptional regulator
CVT27_RS08420	COG3845	ABC transporter
CVT27_RS08430	COG0183	Belongs to the thiolase family
CVT27_RS08435	COG2124	cytochrome p450
CVT27_RS08485	COG2259	Doxx family
CVT27_RS08525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CVT27_RS08560	COG1358	cellular component organization or biogenesis
CVT27_RS08610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVT27_RS08620	COG0477	Major facilitator Superfamily
CVT27_RS08625	COG1309	transcriptional regulator
CVT27_RS08640	COG4585	Histidine kinase
CVT27_RS08645	COG2197	response regulator
CVT27_RS08660	COG0667	Aldo Keto reductase
CVT27_RS08665	COG0789	Transcriptional regulator
CVT27_RS08690	COG1741	Belongs to the pirin family
CVT27_RS08705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS08710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS08715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS08740	COG1309	transcriptional regulator
CVT27_RS08750	COG1764	response to oxidative stress
CVT27_RS08755	COG2130	NADP-dependent
CVT27_RS08785	COG1522	sequence-specific DNA binding
CVT27_RS08795	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS08800	COG0825	malonyl-CoA metabolic process
CVT27_RS08800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVT27_RS08810	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS08820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CVT27_RS08845	COG1070	Carbohydrate kinase
CVT27_RS08860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVT27_RS08865	COG0358	DNA primase activity
CVT27_RS08870	COG2226	methyltransferase
CVT27_RS08880	COG0477	Major facilitator Superfamily
CVT27_RS08890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CVT27_RS08945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVT27_RS08945	COG2146	nitrite reductase [NAD(P)H] activity
CVT27_RS08950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVT27_RS08950	COG2146	nitrite reductase [NAD(P)H] activity
CVT27_RS08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVT27_RS08970	COG0574	Belongs to the PEP-utilizing enzyme family
CVT27_RS08980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVT27_RS08985	COG2011	ABC-type metal ion transport system permease component
CVT27_RS09000	COG2188	Transcriptional regulator
CVT27_RS09055	COG4942	peptidase
CVT27_RS09090	COG2066	Belongs to the glutaminase family
CVT27_RS09145	COG4221	oxidoreductase activity
CVT27_RS09160	COG2197	response regulator
CVT27_RS09190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVT27_RS09220	COG0423	glycine-tRNA ligase activity
CVT27_RS09225	COG3443	Belongs to the bacterial solute-binding protein 9 family
CVT27_RS09225	COG0803	Belongs to the bacterial solute-binding protein 9 family
CVT27_RS09230	COG1121	(ABC) transporter
CVT27_RS09235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVT27_RS09245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVT27_RS09250	COG1381	Involved in DNA repair and RecF pathway recombination
CVT27_RS09260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVT27_RS09275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVT27_RS09285	COG2315	Protein conserved in bacteria
CVT27_RS09295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVT27_RS09305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVT27_RS09315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVT27_RS09320	COG1234	tRNA 3'-trailer cleavage
CVT27_RS09325	COG0537	adenosine 5'-monophosphoramidase activity
CVT27_RS09340	COG0484	heat shock protein binding
CVT27_RS09345	COG1420	regulation of RNA biosynthetic process
CVT27_RS09370	COG1022	Amp-dependent synthetase and ligase
CVT27_RS09375	COG0481	GTPase activity
CVT27_RS09380	COG0268	Binds directly to 16S ribosomal RNA
CVT27_RS09395	COG2353	YceI-like domain
CVT27_RS09405	COG1555	photosystem II stabilization
CVT27_RS09410	COG1307	EDD domain protein, DegV family
CVT27_RS09420	COG0495	leucyl-tRNA aminoacylation
CVT27_RS09455	COG0588	phosphoglycerate mutase activity
CVT27_RS09460	COG0799	negative regulation of ribosome biogenesis
CVT27_RS09470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVT27_RS09475	COG0501	Belongs to the peptidase M48B family
CVT27_RS09490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVT27_RS09500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CVT27_RS09525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVT27_RS09530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVT27_RS09535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVT27_RS09575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVT27_RS09580	COG1530	ribonuclease E activity
CVT27_RS09605	COG0772	Belongs to the SEDS family
CVT27_RS09610	COG0768	penicillin binding
CVT27_RS09625	COG1077	Cell shape determining protein MreB Mrl
CVT27_RS09630	COG0105	UTP biosynthetic process
CVT27_RS09640	COG0285	dihydrofolate synthase activity
CVT27_RS09645	COG0525	valine-tRNA ligase activity
CVT27_RS09655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVT27_RS09660	COG0740	serine-type endopeptidase activity
CVT27_RS09665	COG0740	serine-type endopeptidase activity
CVT27_RS09670	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVT27_RS09695	COG3594	Acyltransferase
CVT27_RS09700	COG0475	glutathione-regulated potassium exporter activity
CVT27_RS09710	COG4552	Acetyltransferase involved in intracellular survival and related
CVT27_RS09725	COG1113	amino acid transport
CVT27_RS09730	COG1268	BioY protein
CVT27_RS09735	COG1113	amino acid transport
CVT27_RS09740	COG1113	amino acid transport
CVT27_RS09750	COG0783	Belongs to the Dps family
CVT27_RS09755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVT27_RS09760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVT27_RS09765	COG0640	Transcriptional regulator
CVT27_RS09780	COG0110	maltose O-acetyltransferase activity
CVT27_RS09790	COG3655	Transcriptional regulator
CVT27_RS09800	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS09815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CVT27_RS09850	COG4266	Belongs to the allantoicase family
CVT27_RS09870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CVT27_RS09880	COG0668	transmembrane transport
CVT27_RS09885	COG1940	carbohydrate kinase activity
CVT27_RS09895	COG1175	transmembrane transport
CVT27_RS09900	COG0395	ABC-type sugar transport system, permease component
CVT27_RS09905	COG1486	melibiose metabolic process
CVT27_RS09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS09950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVT27_RS09955	COG2346	COG2346, Truncated hemoglobins
CVT27_RS09980	COG0629	single-stranded DNA binding
CVT27_RS09985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVT27_RS10000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVT27_RS10020	COG4585	Histidine kinase
CVT27_RS10045	COG1131	(ABC) transporter
CVT27_RS10060	COG3962	Belongs to the TPP enzyme family
CVT27_RS10065	COG3718	enzyme involved in inositol metabolism
CVT27_RS10085	COG2318	DinB family
CVT27_RS10095	COG0500	methyltransferase
CVT27_RS10095	COG3615	Tellurite resistance protein tehB
CVT27_RS10100	COG2409	Drug exporters of the RND superfamily
CVT27_RS10125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVT27_RS10210	COG0673	inositol 2-dehydrogenase activity
CVT27_RS10215	COG1609	Transcriptional regulator
CVT27_RS10270	COG1404	Belongs to the peptidase S8 family
CVT27_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS10320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS10325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS10330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS10335	COG1472	Belongs to the glycosyl hydrolase 3 family
CVT27_RS10365	COG3960	tartronate-semialdehyde synthase activity
CVT27_RS10385	COG1396	sequence-specific DNA binding
CVT27_RS10405	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS10410	COG1946	Acyl-CoA thioesterase
CVT27_RS10430	COG2755	lipolytic protein G-D-S-L family
CVT27_RS10430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CVT27_RS10435	COG0515	serine threonine protein kinase
CVT27_RS10435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVT27_RS10450	COG1309	transcriptional regulator
CVT27_RS10455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVT27_RS10470	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS10490	COG0076	glutamate decarboxylase activity
CVT27_RS10495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CVT27_RS10520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVT27_RS10525	COG0589	response to stress
CVT27_RS10530	COG4977	sequence-specific DNA binding
CVT27_RS10560	COG0395	ABC-type sugar transport system, permease component
CVT27_RS10575	COG2985	domain, Protein
CVT27_RS10615	COG0588	phosphoglycerate mutase activity
CVT27_RS10670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS10685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS10690	COG0765	amino acid transport
CVT27_RS10695	COG0765	amino acid transport
CVT27_RS10700	COG1126	abc transporter atp-binding protein
CVT27_RS10715	COG3397	chitin binding
CVT27_RS10785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS10790	COG2188	Transcriptional regulator
CVT27_RS10820	COG0673	inositol 2-dehydrogenase activity
CVT27_RS10825	COG4702	Belongs to the UPF0303 family
CVT27_RS10835	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
CVT27_RS10835	COG0706	membrane insertase activity
CVT27_RS10845	COG3764	Sortase (surface protein transpeptidase)
CVT27_RS10895	COG1215	transferase activity, transferring glycosyl groups
CVT27_RS10905	COG0745	RESPONSE REGULATOR receiver
CVT27_RS10925	COG3409	Peptidoglycan-binding domain 1 protein
CVT27_RS10935	COG0789	Transcriptional regulator
CVT27_RS10970	COG0697	spore germination
CVT27_RS10975	COG0546	phosphoglycolate phosphatase activity
CVT27_RS10985	COG2313	pseudouridylate synthase activity
CVT27_RS10990	COG2733	membrane
CVT27_RS11010	COG4555	ABC transporter
CVT27_RS11025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVT27_RS11050	COG0477	Major facilitator Superfamily
CVT27_RS11060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVT27_RS11070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVT27_RS11075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVT27_RS11080	COG1263	PTS System
CVT27_RS11085	COG1263	PTS System
CVT27_RS11090	COG1234	tRNA 3'-trailer cleavage
CVT27_RS11120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS11135	COG1113	amino acid transport
CVT27_RS11150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVT27_RS11160	COG1335	isochorismatase
CVT27_RS11195	COG0277	FAD linked oxidase domain protein
CVT27_RS11205	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CVT27_RS11215	COG1174	glycine betaine transport
CVT27_RS11225	COG1174	glycine betaine transport
CVT27_RS11230	COG1732	Glycine betaine
CVT27_RS11235	COG3480	Lon protease (S16) C-terminal proteolytic domain
CVT27_RS11245	COG1061	Type III restriction enzyme res subunit
CVT27_RS11250	COG3654	unkown
CVT27_RS11290	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CVT27_RS11295	COG0395	ABC-type sugar transport system, permease component
CVT27_RS11315	COG1678	Uncharacterized ACR, COG1678
CVT27_RS11320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVT27_RS11325	COG0776	regulation of translation
CVT27_RS11335	COG3973	AAA domain
CVT27_RS11335	COG3973	AAA domain
CVT27_RS11370	COG2223	nitrite transmembrane transporter activity
CVT27_RS11375	COG0583	DNA-binding transcription factor activity
CVT27_RS11425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVT27_RS11430	COG0793	Belongs to the peptidase S41A family
CVT27_RS11435	COG2177	Part of the ABC transporter FtsEX involved in
CVT27_RS11440	COG2884	Cell division ATP-binding protein ftsE
CVT27_RS11455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CVT27_RS11460	COG0515	serine threonine protein kinase
CVT27_RS11465	COG0515	serine threonine protein kinase
CVT27_RS11475	COG1653	transport
CVT27_RS11480	COG1175	transmembrane transport
CVT27_RS11485	COG0395	ABC-type sugar transport system, permease component
CVT27_RS11495	COG1309	transcriptional regulator
CVT27_RS11505	COG1134	teichoic acid transport
CVT27_RS11510	COG2902	Dehydrogenase
CVT27_RS11535	COG0653	protein targeting
CVT27_RS11550	COG2197	response regulator
CVT27_RS11555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVT27_RS11560	COG1040	competence protein
CVT27_RS11565	COG0823	Involved in the tonB-independent uptake of proteins
CVT27_RS11570	COG5000	phosphorelay sensor kinase activity
CVT27_RS11570	COG5002	protein histidine kinase activity
CVT27_RS11575	COG0745	RESPONSE REGULATOR receiver
CVT27_RS11580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CVT27_RS11600	COG0714	Associated with various cellular activities
CVT27_RS11645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CVT27_RS11655	COG1482	cell wall glycoprotein biosynthetic process
CVT27_RS11665	COG2835	tetraacyldisaccharide 4'-kinase activity
CVT27_RS11675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVT27_RS11715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CVT27_RS11720	COG0778	Nitroreductase
CVT27_RS11720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CVT27_RS11730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVT27_RS11745	COG1316	TRANSCRIPTIONal
CVT27_RS11750	COG1316	TRANSCRIPTIONal
CVT27_RS11760	COG1316	TRANSCRIPTIONal
CVT27_RS11770	COG1316	TRANSCRIPTIONal
CVT27_RS11805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CVT27_RS11845	COG2205	protein histidine kinase activity
CVT27_RS11850	COG0745	RESPONSE REGULATOR receiver
CVT27_RS11855	COG3104	oligopeptide transport
CVT27_RS11885	COG1366	Belongs to the anti-sigma-factor antagonist family
CVT27_RS11890	COG1191	sigma factor activity
CVT27_RS11895	COG1228	amidohydrolase
CVT27_RS11905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVT27_RS11910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CVT27_RS11915	COG0531	amino acid
CVT27_RS11960	COG2755	lipolytic protein G-D-S-L family
CVT27_RS11965	COG0183	Belongs to the thiolase family
CVT27_RS11990	COG0577	efflux transmembrane transporter activity
CVT27_RS11990	COG1136	(ABC) transporter
CVT27_RS11995	COG0577	efflux transmembrane transporter activity
CVT27_RS11995	COG1136	(ABC) transporter
CVT27_RS12000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVT27_RS12005	COG1252	NADH dehydrogenase
CVT27_RS12030	COG0148	phosphopyruvate hydratase activity
CVT27_RS12050	COG2124	cytochrome p450
CVT27_RS12165	COG1994	Peptidase M50
CVT27_RS12195	COG3629	intracellular signal transduction
CVT27_RS12195	COG3903	Transcriptional regulator
CVT27_RS12205	COG0577	efflux transmembrane transporter activity
CVT27_RS12210	COG1136	(ABC) transporter
CVT27_RS12225	COG0477	Major facilitator Superfamily
CVT27_RS12255	COG2124	cytochrome p450
CVT27_RS12290	COG4585	Histidine kinase
CVT27_RS12305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVT27_RS12310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVT27_RS12315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVT27_RS12320	COG0193	aminoacyl-tRNA hydrolase activity
CVT27_RS12330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVT27_RS12350	COG4106	trans-aconitate 2-methyltransferase activity
CVT27_RS12360	COG2197	response regulator
CVT27_RS12370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CVT27_RS12385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVT27_RS12410	COG0488	(ABC) transporter
CVT27_RS12415	COG2161	toxin-antitoxin pair type II binding
CVT27_RS12420	COG4115	mRNA cleavage
CVT27_RS12445	COG2813	Specifically methylates the guanine in position
CVT27_RS12450	COG2318	DinB family
CVT27_RS12455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVT27_RS12460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVT27_RS12470	COG0084	hydrolase, TatD family'
CVT27_RS12540	COG0442	prolyl-tRNA aminoacylation
CVT27_RS12585	COG1115	amino acid carrier protein
CVT27_RS12615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CVT27_RS12620	COG1122	ATPase activity
CVT27_RS12630	COG0310	cobalt ion transport
CVT27_RS12640	COG2409	Drug exporters of the RND superfamily
CVT27_RS12650	COG0793	Belongs to the peptidase S41A family
CVT27_RS12650	COG4946	Tricorn protease homolog
CVT27_RS12675	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS12685	COG2072	flavoprotein involved in K transport
CVT27_RS12695	COG0708	Exodeoxyribonuclease III
CVT27_RS12705	COG2340	Cysteine-rich secretory protein family
CVT27_RS12735	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVT27_RS12740	COG0315	cyclic pyranopterin monophosphate synthase activity
CVT27_RS12750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVT27_RS12755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVT27_RS12765	COG3263	regulation of cellular component size
CVT27_RS12780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CVT27_RS12790	COG1970	mechanosensitive ion channel activity
CVT27_RS12810	COG0437	4 iron, 4 sulfur cluster binding
CVT27_RS12815	COG0243	molybdopterin cofactor binding
CVT27_RS12835	COG0477	Major facilitator Superfamily
CVT27_RS12855	COG3384	dioxygenase
CVT27_RS12860	COG1846	Transcriptional regulator
CVT27_RS12880	COG1022	Amp-dependent synthetase and ligase
CVT27_RS12890	COG2197	response regulator
CVT27_RS12920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVT27_RS12925	COG0475	glutathione-regulated potassium exporter activity
CVT27_RS12950	COG0463	Glycosyl transferase, family 2
CVT27_RS12980	COG3629	intracellular signal transduction
CVT27_RS12980	COG3903	Transcriptional regulator
CVT27_RS12990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CVT27_RS13030	COG1686	Belongs to the peptidase S11 family
CVT27_RS13080	COG3655	Transcriptional regulator
CVT27_RS13110	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVT27_RS13120	COG0768	penicillin binding
CVT27_RS13155	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVT27_RS13180	COG0667	Aldo Keto reductase
CVT27_RS13185	COG1309	transcriptional regulator
CVT27_RS13205	COG0454	-acetyltransferase
CVT27_RS13230	COG0076	glutamate decarboxylase activity
CVT27_RS13300	COG0183	Belongs to the thiolase family
CVT27_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS13320	COG1309	transcriptional regulator
CVT27_RS13350	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS13370	COG1301	dicarboxylic acid transport
CVT27_RS13385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVT27_RS13395	COG0163	prenyltransferase activity
CVT27_RS13405	COG0109	protoheme IX farnesyltransferase activity
CVT27_RS13410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVT27_RS13420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVT27_RS13425	COG1333	cytochrome c biogenesis protein
CVT27_RS13430	COG0785	Cytochrome C biogenesis protein
CVT27_RS13445	COG2382	esterase
CVT27_RS13450	COG0406	alpha-ribazole phosphatase activity
CVT27_RS13455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVT27_RS13500	COG1690	Belongs to the RtcB family
CVT27_RS13520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVT27_RS13525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CVT27_RS13530	COG0018	arginyl-trna synthetase
CVT27_RS13540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVT27_RS13575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CVT27_RS13605	COG0113	porphobilinogen synthase activity
CVT27_RS13610	COG1648	precorrin-2 dehydrogenase activity
CVT27_RS13610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVT27_RS13615	COG0181	hydroxymethylbilane synthase activity
CVT27_RS13620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVT27_RS13625	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CVT27_RS13680	COG2223	nitrite transmembrane transporter activity
CVT27_RS13685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS13710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CVT27_RS13720	COG1129	ABC transporter
CVT27_RS13720	COG0842	Transport permease protein
CVT27_RS13730	COG4991	sh3 domain protein
CVT27_RS13740	COG0129	dihydroxy-acid dehydratase activity
CVT27_RS13750	COG1082	Xylose isomerase domain protein TIM barrel
CVT27_RS13755	COG0248	Ppx GppA phosphatase
CVT27_RS13775	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CVT27_RS13790	COG1194	a g-specific adenine glycosylase
CVT27_RS13795	COG1595	DNA-templated transcription, initiation
CVT27_RS13805	COG0745	RESPONSE REGULATOR receiver
CVT27_RS13810	COG2205	protein histidine kinase activity
CVT27_RS13815	COG0739	heme binding
CVT27_RS13860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVT27_RS13880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CVT27_RS13890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVT27_RS13895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVT27_RS13920	COG2197	response regulator
CVT27_RS13935	COG0649	NAD binding
CVT27_RS13950	COG1174	glycine betaine transport
CVT27_RS13955	COG1174	glycine betaine transport
CVT27_RS13960	COG1125	glycine betaine transport
CVT27_RS13960	COG0517	IMP dehydrogenase activity
CVT27_RS13970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CVT27_RS13970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVT27_RS13985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVT27_RS14000	COG0302	gtp cyclohydrolase
CVT27_RS14015	COG0037	tRNA processing
CVT27_RS14025	COG2027	D-alanyl-D-alanine carboxypeptidase
CVT27_RS14030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVT27_RS14040	COG0586	Pfam SNARE associated Golgi protein
CVT27_RS14055	COG0655	NAD(P)H dehydrogenase (quinone) activity
CVT27_RS14060	COG0076	glutamate decarboxylase activity
CVT27_RS14080	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS14115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVT27_RS14115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVT27_RS14145	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CVT27_RS14155	COG1725	Transcriptional regulator
CVT27_RS14170	COG0326	Molecular chaperone. Has ATPase activity
CVT27_RS14180	COG2205	protein histidine kinase activity
CVT27_RS14200	COG0372	Belongs to the citrate synthase family
CVT27_RS14215	COG4948	Mandelate Racemase Muconate Lactonizing
CVT27_RS14220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVT27_RS14225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS14240	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVT27_RS14255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVT27_RS14260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVT27_RS14265	COG1754	DNA topoisomerase type I activity
CVT27_RS14265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVT27_RS14275	COG2890	protein-(glutamine-N5) methyltransferase activity
CVT27_RS14285	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CVT27_RS14295	COG1366	Belongs to the anti-sigma-factor antagonist family
CVT27_RS14300	COG1111	helicase
CVT27_RS14300	COG1205	dead DEAH box helicase
CVT27_RS14360	COG0288	reversible hydration of carbon dioxide
CVT27_RS14365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVT27_RS14370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVT27_RS14380	COG2267	carboxylic ester hydrolase activity
CVT27_RS14410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVT27_RS14435	COG0003	Pfam Anion-transporting ATPase
CVT27_RS14450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CVT27_RS14455	COG1610	YqeY-like protein
CVT27_RS14460	COG1408	metallophosphoesterase
CVT27_RS14525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVT27_RS14535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVT27_RS14555	COG1401	restriction endodeoxyribonuclease activity
CVT27_RS14590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CVT27_RS14595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVT27_RS14600	COG0515	serine threonine protein kinase
CVT27_RS14630	COG2755	lipolytic protein G-D-S-L family
CVT27_RS14640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVT27_RS14660	COG1595	DNA-templated transcription, initiation
CVT27_RS14690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVT27_RS14695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVT27_RS14710	COG1802	Transcriptional regulator
CVT27_RS14720	COG0693	protein deglycase activity
CVT27_RS14730	COG0515	serine threonine protein kinase
CVT27_RS14730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVT27_RS14735	COG0738	Major facilitator superfamily
CVT27_RS14745	COG3226	Transcriptional regulator
CVT27_RS14760	COG0592	DNA-directed DNA polymerase activity
CVT27_RS14770	COG0667	Aldo Keto reductase
CVT27_RS14795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS14805	COG0662	Cupin 2, conserved barrel domain protein
CVT27_RS14810	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS14860	COG2076	Multidrug Resistance protein
CVT27_RS14870	COG0590	tRNA wobble adenosine to inosine editing
CVT27_RS14880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CVT27_RS14885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVT27_RS14910	COG2197	response regulator
CVT27_RS14920	COG0702	epimerase
CVT27_RS14930	COG3844	kynureninase activity
CVT27_RS14945	COG0477	Major facilitator Superfamily
CVT27_RS14950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CVT27_RS14955	COG0191	fructose-bisphosphate aldolase activity
CVT27_RS14960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVT27_RS14975	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVT27_RS15000	COG0542	response to heat
CVT27_RS15030	COG0789	Transcriptional regulator
CVT27_RS15035	COG0484	heat shock protein binding
CVT27_RS15040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVT27_RS15045	COG0443	Heat shock 70 kDa protein
CVT27_RS15055	COG0247	lactate metabolic process
CVT27_RS15055	COG2181	nitrate reductase activity
CVT27_RS15075	COG0717	Belongs to the dCTP deaminase family
CVT27_RS15110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CVT27_RS15175	COG1309	transcriptional regulator
CVT27_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS15195	COG2197	response regulator
CVT27_RS15215	COG2205	protein histidine kinase activity
CVT27_RS15220	COG0745	RESPONSE REGULATOR receiver
CVT27_RS15235	COG1376	ErfK ybiS ycfS ynhG family protein
CVT27_RS15240	COG3046	protein related to deoxyribodipyrimidine photolyase
CVT27_RS15245	COG1533	DNA photolyase activity
CVT27_RS15255	COG2130	NADP-dependent
CVT27_RS15275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVT27_RS15345	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS15360	COG0367	asparagine synthase
CVT27_RS15375	COG1902	pentaerythritol trinitrate reductase activity
CVT27_RS15420	COG0745	RESPONSE REGULATOR receiver
CVT27_RS15430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVT27_RS15440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVT27_RS15455	COG0519	Catalyzes the synthesis of GMP from XMP
CVT27_RS15455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVT27_RS15480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS15495	COG1695	Transcriptional regulator
CVT27_RS15505	COG0667	Aldo Keto reductase
CVT27_RS15515	COG1609	Transcriptional regulator
CVT27_RS15540	COG2124	cytochrome p450
CVT27_RS15545	COG2124	cytochrome p450
CVT27_RS15570	COG3585	molybdate ion transport
CVT27_RS15605	COG0475	glutathione-regulated potassium exporter activity
CVT27_RS15620	COG0513	Belongs to the DEAD box helicase family
CVT27_RS15625	COG1278	Cold shock
CVT27_RS15665	COG0454	-acetyltransferase
CVT27_RS15690	COG2268	Band 7 protein
CVT27_RS15725	COG0490	domain, Protein
CVT27_RS15730	COG0475	glutathione-regulated potassium exporter activity
CVT27_RS15755	COG2255	four-way junction helicase activity
CVT27_RS15765	COG0180	Tryptophanyl-tRNA synthetase
CVT27_RS15770	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CVT27_RS15775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS15805	COG0431	NADPH-dependent FMN reductase
CVT27_RS15835	COG2304	oxidoreductase activity
CVT27_RS15840	COG2205	protein histidine kinase activity
CVT27_RS15845	COG0745	RESPONSE REGULATOR receiver
CVT27_RS15850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVT27_RS15865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVT27_RS15880	COG1741	Belongs to the pirin family
CVT27_RS15890	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS15895	COG1362	aminopeptidase activity
CVT27_RS15915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVT27_RS15930	COG1802	Transcriptional regulator
CVT27_RS15970	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVT27_RS15975	COG0022	dehydrogenase e1 component
CVT27_RS16000	COG0515	serine threonine protein kinase
CVT27_RS16005	COG0515	serine threonine protein kinase
CVT27_RS16025	COG1136	(ABC) transporter
CVT27_RS16025	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVT27_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS16040	COG3321	synthase
CVT27_RS16040	COG0604	alcohol dehydrogenase
CVT27_RS16045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVT27_RS16055	COG0746	molybdenum cofactor guanylyltransferase activity
CVT27_RS16075	COG1522	sequence-specific DNA binding
CVT27_RS16080	COG1309	transcriptional regulator
CVT27_RS16105	COG3396	Phenylacetate-CoA oxygenase
CVT27_RS16110	COG3460	Phenylacetate-CoA oxygenase
CVT27_RS16115	COG3396	Phenylacetate-CoA oxygenase
CVT27_RS16120	COG2151	metal-sulfur cluster biosynthetic enzyme
CVT27_RS16125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVT27_RS16130	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS16135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVT27_RS16160	COG1716	ATPase activity
CVT27_RS16165	COG1716	ATPase activity
CVT27_RS16180	COG0768	penicillin binding
CVT27_RS16185	COG0515	serine threonine protein kinase
CVT27_RS16190	COG3764	Sortase (surface protein transpeptidase)
CVT27_RS16195	COG3764	Sortase (surface protein transpeptidase)
CVT27_RS16210	COG3764	Sortase (surface protein transpeptidase)
CVT27_RS16225	COG0705	Rhomboid family
CVT27_RS16255	COG0515	serine threonine protein kinase
CVT27_RS16290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CVT27_RS16300	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CVT27_RS16305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVT27_RS16310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CVT27_RS16315	COG0592	DNA-directed DNA polymerase activity
CVT27_RS16335	COG0594	ribonuclease P activity
CVT27_RS16340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVT27_RS16345	COG0706	membrane insertase activity
CVT27_RS16355	COG0357	Ribosomal RNA small subunit methyltransferase G
CVT27_RS16360	COG1192	Involved in chromosome partitioning
CVT27_RS16375	COG3118	belongs to the thioredoxin family
CVT27_RS16380	COG0492	ferredoxin-NADP+ reductase activity
CVT27_RS16390	COG1595	DNA-templated transcription, initiation
CVT27_RS16395	COG2815	serine threonine protein kinase
CVT27_RS16395	COG0515	serine threonine protein kinase
CVT27_RS16410	COG0617	tRNA 3'-terminal CCA addition
CVT27_RS16430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVT27_RS16455	COG0360	Binds together with S18 to 16S ribosomal RNA
CVT27_RS16460	COG0629	single-stranded DNA binding
CVT27_RS16465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVT27_RS16470	COG0359	binds to the 23S rRNA
CVT27_RS16475	COG0534	Mate efflux family protein
CVT27_RS16480	COG0305	Participates in initiation and elongation during chromosome replication
CVT27_RS16510	COG2814	Major facilitator Superfamily
CVT27_RS16530	COG0626	cystathionine gamma-synthase activity
CVT27_RS16535	COG1950	PFAM Membrane protein of
CVT27_RS16540	COG0662	Cupin 2, conserved barrel domain protein
CVT27_RS16565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVT27_RS16570	COG3152	Membrane
CVT27_RS16580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVT27_RS16585	COG1609	Transcriptional regulator
CVT27_RS16590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVT27_RS16595	COG1271	oxidase subunit
CVT27_RS16600	COG1294	oxidase, subunit
CVT27_RS16605	COG4988	ABC transporter
CVT27_RS16615	COG0561	phosphatase activity
CVT27_RS16625	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CVT27_RS16630	COG0789	Transcriptional regulator
CVT27_RS16645	COG1131	(ABC) transporter
CVT27_RS16670	COG0561	phosphatase activity
CVT27_RS16675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVT27_RS16680	COG0077	Prephenate dehydratase
CVT27_RS16685	COG2837	iron assimilation
CVT27_RS16690	COG2372	response to copper ion
CVT27_RS16700	COG1999	signal sequence binding
CVT27_RS16720	COG0006	proline dipeptidase activity
CVT27_RS16740	COG0653	protein targeting
CVT27_RS16755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVT27_RS16780	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS16805	COG1595	DNA-templated transcription, initiation
CVT27_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS16915	COG0745	RESPONSE REGULATOR receiver
CVT27_RS16920	COG2205	protein histidine kinase activity
CVT27_RS16930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVT27_RS16945	COG0477	Major facilitator Superfamily
CVT27_RS16960	COG3467	pyridoxamine 5'-phosphate
CVT27_RS16965	COG2353	YceI-like domain
CVT27_RS16975	COG1846	Transcriptional regulator
CVT27_RS16990	COG1191	sigma factor activity
CVT27_RS16995	COG1191	sigma factor activity
CVT27_RS17015	COG1518	maintenance of DNA repeat elements
CVT27_RS17180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVT27_RS17215	COG4941	Belongs to the sigma-70 factor family
CVT27_RS17240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVT27_RS17265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CVT27_RS17300	COG2815	serine threonine protein kinase
CVT27_RS17300	COG0515	serine threonine protein kinase
CVT27_RS17305	COG0492	ferredoxin-NADP+ reductase activity
CVT27_RS17445	COG0151	Belongs to the GarS family
CVT27_RS17460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVT27_RS17475	COG2197	response regulator
CVT27_RS17490	COG1131	(ABC) transporter
CVT27_RS17510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVT27_RS17515	COG0047	phosphoribosylformylglycinamidine synthase activity
CVT27_RS17520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVT27_RS17530	COG0739	heme binding
CVT27_RS17530	COG1196	nuclear chromosome segregation
CVT27_RS17530	COG0741	lytic transglycosylase activity
CVT27_RS17535	COG2318	DinB family
CVT27_RS17550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVT27_RS17585	COG1643	Atp-dependent helicase
CVT27_RS17595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVT27_RS17595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVT27_RS17600	COG0785	Cytochrome C biogenesis protein
CVT27_RS17635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVT27_RS17645	COG0513	Belongs to the DEAD box helicase family
CVT27_RS17665	COG0789	Transcriptional regulator
CVT27_RS17675	COG0739	heme binding
CVT27_RS17675	COG0741	lytic transglycosylase activity
CVT27_RS17675	COG1196	nuclear chromosome segregation
CVT27_RS17685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVT27_RS17690	COG0579	oxidoreductase
CVT27_RS17715	COG1252	NADH dehydrogenase
CVT27_RS17730	COG1846	Transcriptional regulator
CVT27_RS17805	COG0739	heme binding
CVT27_RS17805	COG1196	nuclear chromosome segregation
CVT27_RS17805	COG0741	lytic transglycosylase activity
CVT27_RS17810	COG0671	phosphoesterase, PA-phosphatase related
CVT27_RS17830	COG1937	Protein conserved in bacteria
CVT27_RS17840	COG0306	phosphate transporter
CVT27_RS17860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CVT27_RS17865	COG0494	nUDIX hydrolase
CVT27_RS17865	COG0406	alpha-ribazole phosphatase activity
CVT27_RS17885	COG1116	anion transmembrane transporter activity
CVT27_RS17890	COG1725	Transcriptional regulator
CVT27_RS17900	COG0456	acetyltransferase
CVT27_RS17920	COG0737	Belongs to the 5'-nucleotidase family
CVT27_RS17985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVT27_RS17990	COG1609	Transcriptional regulator
CVT27_RS17995	COG0745	RESPONSE REGULATOR receiver
CVT27_RS18020	COG2897	thiosulfate sulfurtransferase activity
CVT27_RS18060	COG3485	protocatechuate 3,4-dioxygenase
CVT27_RS18065	COG0735	belongs to the Fur family
CVT27_RS18075	COG1490	D-aminoacyl-tRNA deacylase activity
CVT27_RS18090	COG4552	Acetyltransferase involved in intracellular survival and related
CVT27_RS18150	COG0475	glutathione-regulated potassium exporter activity
CVT27_RS18180	COG4770	biotin carboxylase activity
CVT27_RS18205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS18235	COG0736	holo-[acyl-carrier-protein] synthase activity
CVT27_RS18240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVT27_RS18265	COG2318	DinB family
CVT27_RS18275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS18315	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS18350	COG0588	phosphoglycerate mutase activity
CVT27_RS18365	COG5002	protein histidine kinase activity
CVT27_RS18385	COG1329	Transcriptional regulator
CVT27_RS18390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVT27_RS18395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVT27_RS18405	COG0215	cysteine-tRNA ligase activity
CVT27_RS18420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CVT27_RS18430	COG3842	ATPase activity
CVT27_RS18515	COG2188	Transcriptional regulator
CVT27_RS18520	COG2226	methyltransferase
CVT27_RS18540	COG0745	RESPONSE REGULATOR receiver
CVT27_RS18580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS18620	COG2197	response regulator
CVT27_RS18625	COG4585	Histidine kinase
CVT27_RS18635	COG0666	response to abiotic stimulus
CVT27_RS18660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CVT27_RS18680	COG1105	Belongs to the carbohydrate kinase PfkB family
CVT27_RS18690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVT27_RS18710	COG1877	trehalose-phosphatase activity
CVT27_RS18710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS18715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CVT27_RS18720	COG0463	Glycosyl transferase, family 2
CVT27_RS18770	COG1132	(ABC) transporter
CVT27_RS18785	COG1595	DNA-templated transcription, initiation
CVT27_RS18815	COG0395	ABC-type sugar transport system, permease component
CVT27_RS18820	COG1175	transmembrane transport
CVT27_RS18855	COG4251	negative regulation of phosphorylation
CVT27_RS18860	COG2197	response regulator
CVT27_RS18885	COG1263	PTS System
CVT27_RS18885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVT27_RS18890	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CVT27_RS18895	COG1737	Transcriptional regulator
CVT27_RS18935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVT27_RS18940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVT27_RS18945	COG1984	allophanate hydrolase subunit 2
CVT27_RS18960	COG3142	Participates in the control of copper homeostasis
CVT27_RS18965	COG3973	AAA domain
CVT27_RS18985	COG1061	Type III restriction enzyme res subunit
CVT27_RS18990	COG1846	Transcriptional regulator
CVT27_RS19015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVT27_RS19020	COG1120	ATPase activity
CVT27_RS19025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS19030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS19050	COG1278	Cold shock
CVT27_RS19055	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CVT27_RS19060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVT27_RS19070	COG2814	Major facilitator Superfamily
CVT27_RS19090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CVT27_RS19100	COG2252	PERMEase
CVT27_RS19135	COG0667	Aldo Keto reductase
CVT27_RS19140	COG2267	carboxylic ester hydrolase activity
CVT27_RS19165	COG0515	serine threonine protein kinase
CVT27_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS19180	COG0583	DNA-binding transcription factor activity
CVT27_RS19250	COG1051	belongs to the nudix hydrolase family
CVT27_RS19270	COG1309	transcriptional regulator
CVT27_RS19280	COG0697	spore germination
CVT27_RS19340	COG1335	isochorismatase
CVT27_RS19375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVT27_RS19405	COG2205	protein histidine kinase activity
CVT27_RS19410	COG0277	FAD linked oxidase domain protein
CVT27_RS19410	COG0247	lactate metabolic process
CVT27_RS19415	COG3896	Chloramphenicol phosphotransferase-like protein
CVT27_RS19430	COG5006	permease, DMT superfamily
CVT27_RS19435	COG0494	nUDIX hydrolase
CVT27_RS19440	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
CVT27_RS19460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVT27_RS19475	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS19480	COG1024	Enoyl-CoA hydratase
CVT27_RS19550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVT27_RS19565	COG2124	cytochrome p450
CVT27_RS19590	COG0259	pyridoxamine-phosphate oxidase activity
CVT27_RS19610	COG2205	protein histidine kinase activity
CVT27_RS19615	COG4821	SIS domain
CVT27_RS19625	COG2267	carboxylic ester hydrolase activity
CVT27_RS19655	COG0477	Major facilitator Superfamily
CVT27_RS19670	COG1595	DNA-templated transcription, initiation
CVT27_RS19735	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS19745	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS19750	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS19775	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS19870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVT27_RS19900	COG1024	Enoyl-CoA hydratase
CVT27_RS19925	COG2072	flavoprotein involved in K transport
CVT27_RS19930	COG4592	Periplasmic binding protein
CVT27_RS19935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS19940	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS19970	COG0501	Belongs to the peptidase M48B family
CVT27_RS19975	COG0259	pyridoxamine-phosphate oxidase activity
CVT27_RS19985	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS19995	COG1309	transcriptional regulator
CVT27_RS20020	COG1024	Enoyl-CoA hydratase
CVT27_RS20060	COG1278	Cold shock
CVT27_RS20065	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CVT27_RS20075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVT27_RS20085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVT27_RS20090	COG4521	taurine ABC transporter
CVT27_RS20100	COG2175	clavaminate synthase activity
CVT27_RS20105	COG2226	methyltransferase
CVT27_RS20170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20180	COG0649	NAD binding
CVT27_RS20190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CVT27_RS20195	COG1034	ATP synthesis coupled electron transport
CVT27_RS20200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVT27_RS20205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20210	COG0839	Belongs to the complex I subunit 6 family
CVT27_RS20215	COG0713	ATP synthesis coupled electron transport
CVT27_RS20220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVT27_RS20230	COG1007	ATP synthesis coupled electron transport
CVT27_RS20235	COG0514	ATP-dependent DNA helicase (RecQ)
CVT27_RS20260	COG3104	oligopeptide transport
CVT27_RS20265	COG0142	geranyltranstransferase activity
CVT27_RS20275	COG1131	(ABC) transporter
CVT27_RS20300	COG0561	phosphatase activity
CVT27_RS20340	COG0702	epimerase
CVT27_RS20345	COG1733	regulation of RNA biosynthetic process
CVT27_RS20350	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVT27_RS20355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVT27_RS20355	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVT27_RS20375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVT27_RS20395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVT27_RS20400	COG0839	Belongs to the complex I subunit 6 family
CVT27_RS20405	COG0713	ATP synthesis coupled electron transport
CVT27_RS20410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVT27_RS20420	COG1007	ATP synthesis coupled electron transport
CVT27_RS20425	COG1970	mechanosensitive ion channel activity
CVT27_RS20430	COG0501	Belongs to the peptidase M48B family
CVT27_RS20435	COG3304	Inner membrane component domain
CVT27_RS20440	COG2261	transglycosylase associated protein
CVT27_RS20450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVT27_RS20455	COG1666	GTP binding
CVT27_RS20470	COG0402	S-adenosylhomocysteine deaminase activity
CVT27_RS20485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVT27_RS20490	COG2030	dehydratase
CVT27_RS20500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CVT27_RS20515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVT27_RS20520	COG0436	Aminotransferase
CVT27_RS20540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVT27_RS20545	COG0081	regulation of translation
CVT27_RS20550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVT27_RS20555	COG0222	ribosome binding
CVT27_RS20565	COG0085	RNA polymerase activity
CVT27_RS20570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVT27_RS20675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVT27_RS20680	COG0049	tRNA binding
CVT27_RS20685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVT27_RS20690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVT27_RS20715	COG0051	transcription antitermination factor activity, RNA binding
CVT27_RS20720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVT27_RS20725	COG0088	Forms part of the polypeptide exit tunnel
CVT27_RS20730	COG0089	rRNA binding
CVT27_RS20735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVT27_RS20740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVT27_RS20745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVT27_RS20750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVT27_RS20755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVT27_RS20760	COG0255	Belongs to the universal ribosomal protein uL29 family
CVT27_RS20765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVT27_RS20770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVT27_RS20775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVT27_RS20780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVT27_RS20785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVT27_RS20795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVT27_RS20800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVT27_RS20805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVT27_RS20810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVT27_RS20815	COG1841	ribosomal large subunit assembly
CVT27_RS20820	COG0200	Binds to the 23S rRNA
CVT27_RS20830	COG0563	adenylate kinase activity
CVT27_RS20840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVT27_RS20845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVT27_RS20850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVT27_RS20855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVT27_RS20860	COG0202	RNA polymerase activity
CVT27_RS20865	COG0203	ribosomal protein L17
CVT27_RS20870	COG0101	tRNA pseudouridine synthase activity
CVT27_RS20895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVT27_RS20900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVT27_RS20905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVT27_RS20915	COG1072	(Pantothenic acid kinase))
CVT27_RS20930	COG4566	intracellular signal transduction
CVT27_RS20940	COG0747	negative chemotaxis
CVT27_RS20945	COG3795	YCII-related domain
CVT27_RS20950	COG4941	Belongs to the sigma-70 factor family
CVT27_RS20975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVT27_RS20980	COG0736	holo-[acyl-carrier-protein] synthase activity
CVT27_RS20990	COG3189	MarR family transcriptional regulator
CVT27_RS20995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVT27_RS21005	COG0802	atpase or kinase
CVT27_RS21030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVT27_RS21065	COG0726	polysaccharide deacetylase
CVT27_RS21070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVT27_RS21080	COG4221	oxidoreductase activity
CVT27_RS21090	COG0583	DNA-binding transcription factor activity
CVT27_RS21105	COG1595	DNA-templated transcription, initiation
CVT27_RS21115	COG0516	GMP reductase activity
CVT27_RS21130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVT27_RS21145	COG0515	serine threonine protein kinase
CVT27_RS21150	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS21170	COG0519	Catalyzes the synthesis of GMP from XMP
CVT27_RS21170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVT27_RS21210	COG2197	response regulator
CVT27_RS21245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS21245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS21265	COG0714	Associated with various cellular activities
CVT27_RS21270	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CVT27_RS21275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CVT27_RS21280	COG0045	succinate-CoA ligase (ADP-forming) activity
CVT27_RS21310	COG0138	bifunctional purine biosynthesis protein purh
CVT27_RS21325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVT27_RS21340	COG0039	L-malate dehydrogenase activity
CVT27_RS21345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVT27_RS21350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVT27_RS21360	COG0754	glutathionylspermidine amidase activity
CVT27_RS21365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVT27_RS21370	COG0180	Tryptophanyl-tRNA synthetase
CVT27_RS21390	COG1295	ribonuclease BN
CVT27_RS21395	COG1686	Belongs to the peptidase S11 family
CVT27_RS21405	COG1408	metallophosphoesterase
CVT27_RS21435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVT27_RS21440	COG1053	succinate dehydrogenase
CVT27_RS21450	COG2009	succinate dehydrogenase
CVT27_RS21510	COG1595	DNA-templated transcription, initiation
CVT27_RS21540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CVT27_RS21550	COG1216	Glycosyl transferase, family 2
CVT27_RS21560	COG1083	cytidylyl-transferase
CVT27_RS21565	COG2089	acid synthase
CVT27_RS21575	COG1473	amidohydrolase
CVT27_RS21575	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CVT27_RS21580	COG1744	ABC transporter substrate-binding protein PnrA-like
CVT27_RS21585	COG3845	ABC transporter
CVT27_RS21590	COG4603	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS21595	COG1079	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS21615	COG1404	Belongs to the peptidase S8 family
CVT27_RS21635	COG2814	Major facilitator Superfamily
CVT27_RS21640	COG0583	DNA-binding transcription factor activity
CVT27_RS21655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVT27_RS21680	COG2205	protein histidine kinase activity
CVT27_RS21685	COG0745	RESPONSE REGULATOR receiver
CVT27_RS21690	COG1595	DNA-templated transcription, initiation
CVT27_RS21720	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS21725	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS21740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVT27_RS21760	COG1349	DNA-binding transcription factor activity
CVT27_RS21770	COG4770	biotin carboxylase activity
CVT27_RS21780	COG0424	maF-like protein
CVT27_RS21790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVT27_RS21805	COG1024	Enoyl-CoA hydratase
CVT27_RS21835	COG1376	ErfK ybiS ycfS ynhG family protein
CVT27_RS21850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVT27_RS21855	COG1396	sequence-specific DNA binding
CVT27_RS21870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVT27_RS21890	COG1595	DNA-templated transcription, initiation
CVT27_RS21895	COG0745	RESPONSE REGULATOR receiver
CVT27_RS21900	COG2202	Pas domain
CVT27_RS21900	COG2205	protein histidine kinase activity
CVT27_RS21910	COG2172	sigma factor antagonist activity
CVT27_RS21915	COG1366	Belongs to the anti-sigma-factor antagonist family
CVT27_RS21920	COG1366	Belongs to the anti-sigma-factor antagonist family
CVT27_RS21925	COG2255	four-way junction helicase activity
CVT27_RS21930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVT27_RS21945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVT27_RS21955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CVT27_RS21985	COG1331	Highly conserved protein containing a thioredoxin domain
CVT27_RS21995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CVT27_RS22085	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVT27_RS22100	COG1414	Transcriptional regulator
CVT27_RS22105	COG0251	oxidation-reduction process
CVT27_RS22110	COG2610	gluconate transmembrane transporter activity
CVT27_RS22135	COG2894	cell division
CVT27_RS22165	COG3920	Histidine kinase
CVT27_RS22170	COG2197	response regulator
CVT27_RS22190	COG2885	chlorophyll binding
CVT27_RS22240	COG0667	Aldo Keto reductase
CVT27_RS22245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVT27_RS22255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CVT27_RS22270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVT27_RS22275	COG0450	alkyl hydroperoxide reductase
CVT27_RS22290	COG1136	(ABC) transporter
CVT27_RS22310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVT27_RS22310	COG4499	WXG100 protein secretion system (Wss), protein YukC
CVT27_RS22325	COG0114	fumarate hydratase activity
CVT27_RS22335	COG1362	aminopeptidase activity
CVT27_RS22340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CVT27_RS22340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CVT27_RS22365	COG0778	Nitroreductase
CVT27_RS22370	COG1722	exodeoxyribonuclease VII activity
CVT27_RS22375	COG1570	exodeoxyribonuclease VII activity
CVT27_RS22385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVT27_RS22400	COG0012	GTP binding
CVT27_RS22430	COG0789	Transcriptional regulator
CVT27_RS22470	COG1842	Phage shock protein A
CVT27_RS22480	COG0463	Glycosyl transferase, family 2
CVT27_RS22490	COG4941	Belongs to the sigma-70 factor family
CVT27_RS22495	COG3795	YCII-related domain
CVT27_RS22530	COG0148	phosphopyruvate hydratase activity
CVT27_RS22550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVT27_RS22555	COG2226	methyltransferase
CVT27_RS22565	COG1217	gtp-binding protein TYPA
CVT27_RS22575	COG0747	negative chemotaxis
CVT27_RS22580	COG0601	transmembrane transport
CVT27_RS22585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS22595	COG4608	Belongs to the ABC transporter superfamily
CVT27_RS22600	COG4166	transmembrane transport
CVT27_RS22605	COG0601	transmembrane transport
CVT27_RS22610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS22620	COG4608	Belongs to the ABC transporter superfamily
CVT27_RS22625	COG2197	response regulator
CVT27_RS22640	COG1136	(ABC) transporter
CVT27_RS22640	COG0577	efflux transmembrane transporter activity
CVT27_RS22670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CVT27_RS22690	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CVT27_RS22695	COG1396	sequence-specific DNA binding
CVT27_RS22715	COG0110	maltose O-acetyltransferase activity
CVT27_RS22725	COG0515	serine threonine protein kinase
CVT27_RS22735	COG1132	(ABC) transporter
CVT27_RS22740	COG1132	(ABC) transporter
CVT27_RS22745	COG2197	response regulator
CVT27_RS22750	COG2912	Transglutaminase-like superfamily
CVT27_RS22780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVT27_RS22785	COG1611	Belongs to the LOG family
CVT27_RS22790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVT27_RS22800	COG0519	Catalyzes the synthesis of GMP from XMP
CVT27_RS22805	COG1024	Enoyl-CoA hydratase
CVT27_RS22820	COG1595	DNA-templated transcription, initiation
CVT27_RS22830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVT27_RS22835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVT27_RS22870	COG0598	Magnesium transport protein CorA
CVT27_RS22890	COG2095	MarC family integral membrane protein
CVT27_RS22895	COG1432	Conserved Protein
CVT27_RS22910	COG0513	Belongs to the DEAD box helicase family
CVT27_RS22940	COG0596	Alpha beta hydrolase
CVT27_RS22950	COG0747	negative chemotaxis
CVT27_RS22955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS22960	COG0601	transmembrane transport
CVT27_RS22965	COG4172	Belongs to the ABC transporter superfamily
CVT27_RS23020	COG0210	DNA helicase
CVT27_RS23065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVT27_RS23115	COG3480	Lon protease (S16) C-terminal proteolytic domain
CVT27_RS23125	COG1615	UPF0182 protein
CVT27_RS23150	COG0753	catalase activity
CVT27_RS23160	COG0483	inositol monophosphate 1-phosphatase activity
CVT27_RS23170	COG2076	Multidrug Resistance protein
CVT27_RS23175	COG1162	GTPase activity
CVT27_RS23180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVT27_RS23190	COG2135	peptidase activity
CVT27_RS23200	COG1595	DNA-templated transcription, initiation
CVT27_RS23205	COG5662	AntiSigma factor
CVT27_RS23215	COG0242	peptide deformylase activity
CVT27_RS23320	COG1966	Carbon starvation protein
CVT27_RS23330	COG2182	Extracellular solute-binding protein
CVT27_RS23335	COG1175	transmembrane transport
CVT27_RS23340	COG0395	ABC-type sugar transport system, permease component
CVT27_RS23345	COG1472	Belongs to the glycosyl hydrolase 3 family
CVT27_RS23350	COG0363	glucosamine-6-phosphate deaminase activity
CVT27_RS23355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVT27_RS23375	COG1597	lipid kinase activity
CVT27_RS23390	COG2172	sigma factor antagonist activity
CVT27_RS23435	COG1959	2 iron, 2 sulfur cluster binding
CVT27_RS23440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVT27_RS23445	COG0142	geranyltranstransferase activity
CVT27_RS23525	COG4106	trans-aconitate 2-methyltransferase activity
CVT27_RS23530	COG1126	abc transporter atp-binding protein
CVT27_RS23535	COG0765	amino acid transport
CVT27_RS23540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS23545	COG0281	malic enzyme
CVT27_RS23550	COG0604	alcohol dehydrogenase
CVT27_RS23570	COG0542	response to heat
CVT27_RS23595	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVT27_RS23595	COG0567	Dehydrogenase, E1 component
CVT27_RS23605	COG2205	protein histidine kinase activity
CVT27_RS23610	COG0745	RESPONSE REGULATOR receiver
CVT27_RS23630	COG1131	(ABC) transporter
CVT27_RS23640	COG1595	DNA-templated transcription, initiation
CVT27_RS23645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVT27_RS23650	COG0726	polysaccharide deacetylase
CVT27_RS23725	COG0791	NLP P60 protein
CVT27_RS23725	COG3883	PFAM NLP P60 protein
CVT27_RS23740	COG1309	transcriptional regulator
CVT27_RS23770	COG0768	penicillin binding
CVT27_RS23785	COG2205	protein histidine kinase activity
CVT27_RS23805	COG3285	dna ligase
CVT27_RS23805	COG1793	dna ligase
CVT27_RS23810	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CVT27_RS23835	COG0018	arginyl-trna synthetase
CVT27_RS23840	COG0019	diaminopimelate decarboxylase activity
CVT27_RS23845	COG0460	homoserine dehydrogenase
CVT27_RS23850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVT27_RS23860	COG0083	homoserine kinase activity
CVT27_RS23870	COG1316	TRANSCRIPTIONal
CVT27_RS23875	COG0254	rRNA binding
CVT27_RS23880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVT27_RS23885	COG2890	protein-(glutamine-N5) methyltransferase activity
CVT27_RS23895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVT27_RS23900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVT27_RS23905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVT27_RS23920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVT27_RS23925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVT27_RS23930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVT27_RS23935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVT27_RS23940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVT27_RS23945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVT27_RS23950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVT27_RS23965	COG2197	response regulator
CVT27_RS23970	COG3850	Histidine kinase
CVT27_RS23990	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS24005	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CVT27_RS24060	COG0183	Belongs to the thiolase family
CVT27_RS24070	COG4104	PAAR repeat-containing protein
CVT27_RS24070	COG3209	COG3209 Rhs family protein
CVT27_RS24090	COG0745	RESPONSE REGULATOR receiver
CVT27_RS24095	COG5002	protein histidine kinase activity
CVT27_RS24170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS24170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS24175	COG1597	lipid kinase activity
CVT27_RS24215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVT27_RS24220	COG0857	belongs to the CobB CobQ family
CVT27_RS24220	COG0280	phosphate acetyltransferase
CVT27_RS24225	COG0205	6-phosphofructokinase activity
CVT27_RS24235	COG4565	transcriptional regulatory protein
CVT27_RS24240	COG3290	protein histidine kinase activity
CVT27_RS24245	COG1301	dicarboxylic acid transport
CVT27_RS24250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVT27_RS24255	COG3281	Trehalose synthase
CVT27_RS24260	COG0366	Alpha amylase catalytic
CVT27_RS24265	COG0366	Alpha amylase catalytic
CVT27_RS24270	COG0058	SHG alpha-glucan phosphorylase activity
CVT27_RS24295	COG1132	(ABC) transporter
CVT27_RS24300	COG1132	(ABC) transporter
CVT27_RS24320	COG2197	response regulator
CVT27_RS24340	COG1024	Enoyl-CoA hydratase
CVT27_RS24385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVT27_RS24390	COG0142	geranyltranstransferase activity
CVT27_RS24395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVT27_RS24400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVT27_RS24440	COG0477	Major facilitator Superfamily
CVT27_RS24450	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS24565	COG0823	Involved in the tonB-independent uptake of proteins
CVT27_RS24575	COG1222	aaa ATPase
CVT27_RS24600	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS24615	COG2235	arginine
CVT27_RS24635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVT27_RS24645	COG1760	l-serine dehydratase
CVT27_RS24650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVT27_RS24655	COG0509	glycine decarboxylation via glycine cleavage system
CVT27_RS24660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVT27_RS24680	COG4166	transmembrane transport
CVT27_RS24685	COG0601	transmembrane transport
CVT27_RS24690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS24700	COG4608	Belongs to the ABC transporter superfamily
CVT27_RS24705	COG2860	membrane
CVT27_RS24735	COG0482	sulfurtransferase activity
CVT27_RS24755	COG4221	oxidoreductase activity
CVT27_RS24765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVT27_RS24775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVT27_RS24780	COG0154	amidase activity
CVT27_RS24790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVT27_RS24795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVT27_RS24805	COG2409	Drug exporters of the RND superfamily
CVT27_RS24820	COG2133	pyrroloquinoline quinone binding
CVT27_RS24825	COG0667	Aldo Keto reductase
CVT27_RS24845	COG0440	acetolactate synthase activity
CVT27_RS24850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVT27_RS24855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVT27_RS24880	COG2508	Transcriptional regulator
CVT27_RS24885	COG0506	proline dehydrogenase activity
CVT27_RS24890	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS24905	COG2130	NADP-dependent
CVT27_RS24915	COG0473	3-isopropylmalate dehydrogenase activity
CVT27_RS24920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVT27_RS24930	COG2957	Belongs to the agmatine deiminase family
CVT27_RS24945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVT27_RS24960	COG4608	Belongs to the ABC transporter superfamily
CVT27_RS24965	COG0601	transmembrane transport
CVT27_RS24970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS24975	COG0444	Belongs to the ABC transporter superfamily
CVT27_RS24985	COG1472	Belongs to the glycosyl hydrolase 3 family
CVT27_RS25005	COG3708	Transcriptional regulator
CVT27_RS25005	COG2207	Transcriptional regulator
CVT27_RS25030	COG0492	ferredoxin-NADP+ reductase activity
CVT27_RS25045	COG1733	regulation of RNA biosynthetic process
CVT27_RS25070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS25075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS25080	COG1120	ATPase activity
CVT27_RS25085	COG4607	ABC-type enterochelin transport system periplasmic component
CVT27_RS25110	COG0366	Alpha amylase catalytic
CVT27_RS25110	COG1470	cell adhesion involved in biofilm formation
CVT27_RS25115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVT27_RS25135	COG2018	Roadblock/LC7 domain
CVT27_RS25155	COG2018	Roadblock/LC7 domain
CVT27_RS25160	COG5002	protein histidine kinase activity
CVT27_RS25170	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVT27_RS25175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVT27_RS25210	COG1414	Transcriptional regulator
CVT27_RS25215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVT27_RS25220	COG0066	3-isopropylmalate dehydratase activity
CVT27_RS25230	COG0776	regulation of translation
CVT27_RS25240	COG1920	GTP binding
CVT27_RS25250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVT27_RS25255	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVT27_RS25270	COG0351	phosphomethylpyrimidine kinase
CVT27_RS25275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVT27_RS25280	COG1461	Dihydroxyacetone kinase
CVT27_RS25285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVT27_RS25290	COG0742	ribosomal rna small subunit methyltransferase
CVT27_RS25295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVT27_RS25310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVT27_RS25315	COG0571	ribonuclease III activity
CVT27_RS25320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVT27_RS25325	COG1733	regulation of RNA biosynthetic process
CVT27_RS25330	COG2340	Cysteine-rich secretory protein family
CVT27_RS25335	COG1254	Belongs to the acylphosphatase family
CVT27_RS25350	COG1196	nuclear chromosome segregation
CVT27_RS25355	COG0477	Major facilitator Superfamily
CVT27_RS25390	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVT27_RS25410	COG0228	four-way junction DNA binding
CVT27_RS25415	COG1837	Belongs to the UPF0109 family
CVT27_RS25420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVT27_RS25425	COG0336	Belongs to the RNA methyltransferase TrmD family
CVT27_RS25430	COG0335	large ribosomal subunit rRNA binding
CVT27_RS25445	COG0681	Belongs to the peptidase S26 family
CVT27_RS25450	COG0681	Belongs to the peptidase S26 family
CVT27_RS25465	COG0792	nuclease activity
CVT27_RS25480	COG1191	sigma factor activity
CVT27_RS25495	COG0052	Belongs to the universal ribosomal protein uS2 family
CVT27_RS25500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVT27_RS25505	COG0528	UMP kinase activity
CVT27_RS25510	COG0233	cytoplasmic translational termination
CVT27_RS25520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVT27_RS25535	COG3842	ATPase activity
CVT27_RS25550	COG1136	(ABC) transporter
CVT27_RS25555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVT27_RS25565	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS25590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVT27_RS25610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CVT27_RS25615	COG3842	ATPase activity
CVT27_RS25620	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVT27_RS25625	COG1177	transmembrane transport
CVT27_RS25630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS25660	COG2508	Transcriptional regulator
CVT27_RS25665	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS25675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVT27_RS25680	COG0750	zinc metalloprotease
CVT27_RS25685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVT27_RS25700	COG0442	prolyl-tRNA aminoacylation
CVT27_RS25720	COG0779	Required for maturation of 30S ribosomal subunits
CVT27_RS25735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVT27_RS25745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVT27_RS25750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVT27_RS25795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS25800	COG0601	transmembrane transport
CVT27_RS25805	COG0747	negative chemotaxis
CVT27_RS25810	COG0455	bacterial-type flagellum organization
CVT27_RS25830	COG3266	domain, Protein
CVT27_RS25835	COG1404	Belongs to the peptidase S8 family
CVT27_RS25865	COG1674	ftsk spoiiie
CVT27_RS25875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVT27_RS25880	COG1185	polyribonucleotide nucleotidyltransferase activity
CVT27_RS25885	COG0612	Peptidase, M16
CVT27_RS25890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVT27_RS25910	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CVT27_RS25915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVT27_RS25920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CVT27_RS25950	COG2208	phosphoserine phosphatase activity
CVT27_RS25950	COG2770	Histidine kinase
CVT27_RS25965	COG1674	ftsk spoiiie
CVT27_RS25975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVT27_RS25985	COG1058	Belongs to the CinA family
CVT27_RS25985	COG1546	Belongs to the CinA family
CVT27_RS25990	COG1396	sequence-specific DNA binding
CVT27_RS25995	COG0783	Belongs to the Dps family
CVT27_RS26010	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS26015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVT27_RS26020	COG1201	RNA secondary structure unwinding
CVT27_RS26025	COG2207	Transcriptional regulator
CVT27_RS26025	COG1917	Cupin 2, conserved barrel domain protein
CVT27_RS26060	COG1271	oxidase subunit
CVT27_RS26065	COG2197	response regulator
CVT27_RS26080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CVT27_RS26080	COG1672	PFAM Archaeal ATPase
CVT27_RS26090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVT27_RS26120	COG0765	amino acid transport
CVT27_RS26125	COG0765	amino acid transport
CVT27_RS26130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS26135	COG1126	abc transporter atp-binding protein
CVT27_RS26140	COG0745	RESPONSE REGULATOR receiver
CVT27_RS26145	COG2205	protein histidine kinase activity
CVT27_RS26150	COG2358	TRAP transporter, solute receptor (TAXI family
CVT27_RS26155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVT27_RS26170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVT27_RS26180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVT27_RS26185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVT27_RS26195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVT27_RS26235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVT27_RS26240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVT27_RS26245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVT27_RS26280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVT27_RS26295	COG0514	ATP-dependent DNA helicase (RecQ)
CVT27_RS26310	COG2814	Major facilitator Superfamily
CVT27_RS26325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVT27_RS26330	COG0574	Belongs to the PEP-utilizing enzyme family
CVT27_RS26330	COG3848	Pyruvate phosphate dikinase
CVT27_RS26335	COG1309	transcriptional regulator
CVT27_RS26355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVT27_RS26360	COG2186	Transcriptional regulator
CVT27_RS26365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVT27_RS26390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVT27_RS26395	COG4565	transcriptional regulatory protein
CVT27_RS26400	COG3290	protein histidine kinase activity
CVT27_RS26410	COG0372	Belongs to the citrate synthase family
CVT27_RS26415	COG0372	Belongs to the citrate synthase family
CVT27_RS26425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CVT27_RS26430	COG0612	Peptidase, M16
CVT27_RS26445	COG1802	Transcriptional regulator
CVT27_RS26450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVT27_RS26455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVT27_RS26455	COG1042	CoA-binding domain protein
CVT27_RS26455	COG0045	succinate-CoA ligase (ADP-forming) activity
CVT27_RS26470	COG1435	thymidine kinase activity
CVT27_RS26505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVT27_RS26510	COG0483	inositol monophosphate 1-phosphatase activity
CVT27_RS26520	COG0745	RESPONSE REGULATOR receiver
CVT27_RS26525	COG2205	protein histidine kinase activity
CVT27_RS26550	COG0756	dUTP diphosphatase activity
CVT27_RS26585	COG0569	domain protein
CVT27_RS26590	COG0531	amino acid
CVT27_RS26595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVT27_RS26650	COG0515	serine threonine protein kinase
CVT27_RS26650	COG2815	serine threonine protein kinase
CVT27_RS26670	COG2366	antibiotic biosynthetic process
CVT27_RS26690	COG3629	intracellular signal transduction
CVT27_RS26690	COG3903	Transcriptional regulator
CVT27_RS26695	COG4585	Histidine kinase
CVT27_RS26715	COG0596	Alpha beta hydrolase
CVT27_RS26740	COG0464	growth
CVT27_RS26750	COG1674	ftsk spoiiie
CVT27_RS26835	COG2192	nodulation
CVT27_RS26860	COG0505	Belongs to the CarA family
CVT27_RS26865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVT27_RS26870	COG1280	lysine exporter protein (LysE YggA)
CVT27_RS26875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVT27_RS26885	COG3291	Pkd domain containing protein
CVT27_RS26890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVT27_RS26910	COG3938	Belongs to the proline racemase family
CVT27_RS26915	COG1802	Transcriptional regulator
CVT27_RS26920	COG3835	regulator
CVT27_RS26950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS26955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS26970	COG0586	Pfam SNARE associated Golgi protein
CVT27_RS26975	COG1349	DNA-binding transcription factor activity
CVT27_RS26980	COG1799	cell septum assembly
CVT27_RS27000	COG2040	homocysteine
CVT27_RS27010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVT27_RS27020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVT27_RS27025	COG0531	amino acid
CVT27_RS27035	COG1024	Enoyl-CoA hydratase
CVT27_RS27060	COG0251	oxidation-reduction process
CVT27_RS27065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVT27_RS27065	COG2111	Na H antiporter
CVT27_RS27070	COG1006	Multisubunit Na H antiporter MnhC subunit
CVT27_RS27075	COG0651	ATP synthesis coupled electron transport
CVT27_RS27090	COG1320	monovalent cation:proton antiporter activity
CVT27_RS27105	COG0297	glycogen (starch) synthase activity
CVT27_RS27110	COG0489	protein tyrosine kinase activity
CVT27_RS27145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CVT27_RS27150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVT27_RS27155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVT27_RS27190	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS27225	COG2815	serine threonine protein kinase
CVT27_RS27225	COG0515	serine threonine protein kinase
CVT27_RS27235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVT27_RS27240	COG2267	carboxylic ester hydrolase activity
CVT27_RS27250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVT27_RS27260	COG0406	alpha-ribazole phosphatase activity
CVT27_RS27270	COG1653	transport
CVT27_RS27275	COG1175	transmembrane transport
CVT27_RS27280	COG0395	ABC-type sugar transport system, permease component
CVT27_RS27285	COG1940	carbohydrate kinase activity
CVT27_RS27290	COG4213	ABC transporter substrate-binding protein
CVT27_RS27300	COG4214	carbohydrate transport
CVT27_RS27305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVT27_RS27310	COG0531	amino acid
CVT27_RS27320	COG1316	TRANSCRIPTIONal
CVT27_RS27325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS27325	COG1024	Enoyl-CoA hydratase
CVT27_RS27330	COG0183	Belongs to the thiolase family
CVT27_RS27350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVT27_RS27355	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVT27_RS27365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CVT27_RS27370	COG3253	May function as heme-dependent peroxidase
CVT27_RS27385	COG3220	belongs to the UPF0276 family
CVT27_RS27410	COG2376	Dihydroxyacetone kinase
CVT27_RS27420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS27460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVT27_RS27465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVT27_RS27500	COG2072	flavoprotein involved in K transport
CVT27_RS27530	COG0483	inositol monophosphate 1-phosphatase activity
CVT27_RS27560	COG1100	Small GTP-binding protein
CVT27_RS27585	COG0515	serine threonine protein kinase
CVT27_RS27585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVT27_RS27590	COG1063	alcohol dehydrogenase
CVT27_RS27595	COG0156	8-amino-7-oxononanoate synthase activity
CVT27_RS27610	COG0346	lactoylglutathione lyase activity
CVT27_RS27630	COG2723	6-phospho-beta-galactosidase activity
CVT27_RS27685	COG1175	transmembrane transport
CVT27_RS27705	COG1404	Belongs to the peptidase S8 family
CVT27_RS27720	COG1132	(ABC) transporter
CVT27_RS27725	COG1132	(ABC) transporter
CVT27_RS27735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CVT27_RS27745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVT27_RS27750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVT27_RS27770	COG0529	Catalyzes the synthesis of activated sulfate
CVT27_RS27775	COG0175	sulfate reduction
CVT27_RS27800	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS27820	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS27825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVT27_RS27830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CVT27_RS27835	COG0583	DNA-binding transcription factor activity
CVT27_RS27840	COG0183	Belongs to the thiolase family
CVT27_RS27845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVT27_RS27895	COG1162	GTPase activity
CVT27_RS27915	COG1404	Belongs to the peptidase S8 family
CVT27_RS27925	COG0028	Belongs to the TPP enzyme family
CVT27_RS27945	COG1802	Transcriptional regulator
CVT27_RS27970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVT27_RS27975	COG2252	PERMEase
CVT27_RS27980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CVT27_RS27980	COG3608	succinylglutamate desuccinylase aspartoacylase
CVT27_RS28005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS28035	COG0435	Glutathione S-transferase
CVT27_RS28045	COG2197	response regulator
CVT27_RS28050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVT27_RS28055	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS28075	COG3960	tartronate-semialdehyde synthase activity
CVT27_RS28090	COG3629	intracellular signal transduction
CVT27_RS28090	COG3903	Transcriptional regulator
CVT27_RS28100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS28110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVT27_RS28120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVT27_RS28125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVT27_RS28140	COG0753	catalase activity
CVT27_RS28145	COG2084	Dehydrogenase
CVT27_RS28150	COG3622	Belongs to the hyi family
CVT27_RS28155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CVT27_RS28165	COG0395	ABC-type sugar transport system, permease component
CVT27_RS28170	COG1175	transmembrane transport
CVT27_RS28180	COG2188	Transcriptional regulator
CVT27_RS28200	COG2351	hydroxyisourate hydrolase activity
CVT27_RS28210	COG2233	PERMEase
CVT27_RS28220	COG2233	PERMEase
CVT27_RS28265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVT27_RS28280	COG2197	response regulator
CVT27_RS28300	COG1414	Transcriptional regulator
CVT27_RS28305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVT27_RS28310	COG4266	Belongs to the allantoicase family
CVT27_RS28315	COG0656	L-ascorbic acid biosynthetic process
CVT27_RS28320	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS28385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVT27_RS28390	COG2271	Major facilitator Superfamily
CVT27_RS28400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS28405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVT27_RS28415	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS28435	COG0529	Catalyzes the synthesis of activated sulfate
CVT27_RS28485	COG0673	inositol 2-dehydrogenase activity
CVT27_RS28490	COG2188	Transcriptional regulator
CVT27_RS28505	COG1129	ABC transporter
CVT27_RS28510	COG1940	carbohydrate kinase activity
CVT27_RS28520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVT27_RS28525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVT27_RS28540	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS28575	COG1126	abc transporter atp-binding protein
CVT27_RS28580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVT27_RS28585	COG0765	amino acid transport
CVT27_RS28590	COG0765	amino acid transport
CVT27_RS28600	COG1376	ErfK ybiS ycfS ynhG family protein
CVT27_RS28615	COG0405	Gamma-glutamyltransferase
CVT27_RS28645	COG0667	Aldo Keto reductase
CVT27_RS28655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVT27_RS28660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVT27_RS28685	COG2838	Isocitrate dehydrogenase
CVT27_RS28695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVT27_RS28705	COG0095	Lipoate-protein ligase
CVT27_RS28710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVT27_RS28725	COG1024	Enoyl-CoA hydratase
CVT27_RS28730	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS28750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVT27_RS28765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVT27_RS28805	COG1024	Enoyl-CoA hydratase
CVT27_RS28810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS28840	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS28845	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS28850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS28855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS28865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVT27_RS28875	COG1131	(ABC) transporter
CVT27_RS28880	COG1024	Enoyl-CoA hydratase
CVT27_RS28915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVT27_RS28930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVT27_RS28945	COG1929	Belongs to the glycerate kinase type-1 family
CVT27_RS28965	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS28970	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS29000	COG0688	phosphatidylethanolamine metabolic process
CVT27_RS29005	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS29015	COG2301	Belongs to the HpcH HpaI aldolase family
CVT27_RS29020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS29020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVT27_RS29025	COG0604	alcohol dehydrogenase
CVT27_RS29045	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS29080	COG0667	Aldo Keto reductase
CVT27_RS29090	COG2362	D-Aminopeptidase
CVT27_RS29095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVT27_RS29105	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVT27_RS29120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVT27_RS29135	COG4106	trans-aconitate 2-methyltransferase activity
CVT27_RS29155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVT27_RS29180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVT27_RS29195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVT27_RS29195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVT27_RS29220	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVT27_RS29230	COG4106	trans-aconitate 2-methyltransferase activity
CVT27_RS29240	COG0656	L-ascorbic acid biosynthetic process
CVT27_RS29250	COG0583	DNA-binding transcription factor activity
CVT27_RS29265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVT27_RS29270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS29280	COG1129	ABC transporter
CVT27_RS29285	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVT27_RS29295	COG0673	inositol 2-dehydrogenase activity
CVT27_RS29375	COG1129	ABC transporter
CVT27_RS29385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVT27_RS29390	COG1869	D-ribose catabolic process
CVT27_RS29415	COG5002	protein histidine kinase activity
CVT27_RS29420	COG0745	RESPONSE REGULATOR receiver
CVT27_RS29450	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS29460	COG0517	IMP dehydrogenase activity
CVT27_RS29460	COG4175	Glycine betaine
CVT27_RS29465	COG4176	ABC-type proline glycine betaine transport system permease component
CVT27_RS29475	COG2124	cytochrome p450
CVT27_RS29480	COG0569	domain protein
CVT27_RS29480	COG2985	domain, Protein
CVT27_RS29495	COG1070	Carbohydrate kinase
CVT27_RS29505	COG1940	carbohydrate kinase activity
CVT27_RS29530	COG1846	Transcriptional regulator
CVT27_RS29555	COG2124	cytochrome p450
CVT27_RS29560	COG1486	melibiose metabolic process
CVT27_RS29600	COG3012	SEC-C Motif Domain Protein
CVT27_RS29655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVT27_RS29680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVT27_RS29715	COG2208	phosphoserine phosphatase activity
CVT27_RS29715	COG2770	Histidine kinase
CVT27_RS29735	COG1793	dna ligase
CVT27_RS29810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVT27_RS29815	COG0488	(ABC) transporter
CVT27_RS29830	COG1515	deoxyribonuclease V activity
CVT27_RS29835	COG3268	Saccharopine dehydrogenase
CVT27_RS29840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVT27_RS29845	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS29850	COG0183	Belongs to the thiolase family
CVT27_RS29855	COG1024	Enoyl-CoA hydratase
CVT27_RS29855	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS29860	COG0789	Transcriptional regulator
CVT27_RS29885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVT27_RS29905	COG0488	(ABC) transporter
CVT27_RS29910	COG2183	response to ionizing radiation
CVT27_RS29920	COG4977	sequence-specific DNA binding
CVT27_RS29930	COG1024	Enoyl-CoA hydratase
CVT27_RS29945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CVT27_RS29950	COG2226	methyltransferase
CVT27_RS29980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVT27_RS29995	COG1388	LysM domain
CVT27_RS29995	COG1134	teichoic acid transport
CVT27_RS30000	COG1562	ergosterol biosynthetic process
CVT27_RS30010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CVT27_RS30020	COG1657	PFAM Prenyltransferase squalene oxidase
CVT27_RS30045	COG2365	Tyrosine phosphatase family
CVT27_RS30055	COG2755	lipolytic protein G-D-S-L family
CVT27_RS30065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVT27_RS30105	COG3467	pyridoxamine 5'-phosphate
CVT27_RS30145	COG1609	Transcriptional regulator
CVT27_RS30150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVT27_RS30160	COG1116	anion transmembrane transporter activity
CVT27_RS30190	COG3958	Transketolase
CVT27_RS30195	COG3959	Transketolase, thiamine diphosphate binding domain
CVT27_RS30220	COG1846	Transcriptional regulator
CVT27_RS30220	COG0456	acetyltransferase
CVT27_RS30260	COG1215	transferase activity, transferring glycosyl groups
CVT27_RS30285	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS30300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVT27_RS30315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVT27_RS30335	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS30355	COG3511	phospholipase C
CVT27_RS30365	COG2197	response regulator
CVT27_RS30370	COG3851	Histidine kinase
CVT27_RS30380	COG0247	lactate metabolic process
CVT27_RS30385	COG1139	Iron-sulfur cluster binding protein
CVT27_RS30390	COG1556	Lactate utilization protein
CVT27_RS30410	COG1672	PFAM Archaeal ATPase
CVT27_RS30410	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CVT27_RS30420	COG0318	PFAM AMP-dependent synthetase and ligase
CVT27_RS30430	COG0156	8-amino-7-oxononanoate synthase activity
CVT27_RS30445	COG0604	alcohol dehydrogenase
CVT27_RS30445	COG3321	synthase
CVT27_RS30455	COG0604	alcohol dehydrogenase
CVT27_RS30455	COG3321	synthase
CVT27_RS30460	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVT27_RS30485	COG3903	Transcriptional regulator
CVT27_RS30485	COG3629	intracellular signal transduction
CVT27_RS30510	COG3800	Transcriptional regulator
CVT27_RS30510	COG1396	sequence-specific DNA binding
CVT27_RS30515	COG2079	MmgE PrpD family protein
CVT27_RS30545	COG1316	TRANSCRIPTIONal
CVT27_RS30555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CVT27_RS30560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CVT27_RS30565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CVT27_RS30590	COG0714	Associated with various cellular activities
CVT27_RS30630	COG0831	urea catabolic process
CVT27_RS30640	COG0832	Belongs to the urease beta subunit family
CVT27_RS30640	COG0831	urea catabolic process
CVT27_RS30645	COG0804	urea catabolic process
CVT27_RS30650	COG0830	nickel cation binding
CVT27_RS30655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVT27_RS30660	COG0829	nickel cation binding
CVT27_RS30710	COG1902	pentaerythritol trinitrate reductase activity
CVT27_RS30710	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVT27_RS30725	COG2409	Drug exporters of the RND superfamily
CVT27_RS30730	COG1846	Transcriptional regulator
CVT27_RS30785	COG1233	COG1233 Phytoene dehydrogenase and related
CVT27_RS30790	COG2130	NADP-dependent
CVT27_RS30795	COG2124	cytochrome p450
CVT27_RS30810	COG2080	2 iron, 2 sulfur cluster binding
CVT27_RS30815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVT27_RS30820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVT27_RS30835	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVT27_RS30845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CVT27_RS30855	COG0019	diaminopimelate decarboxylase activity
CVT27_RS30865	COG2837	iron assimilation
CVT27_RS30870	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CVT27_RS30910	COG0596	Alpha beta hydrolase
CVT27_RS30920	COG0395	ABC-type sugar transport system, permease component
CVT27_RS30925	COG1175	transmembrane transport
CVT27_RS30935	COG1940	carbohydrate kinase activity
CVT27_RS30945	COG1652	LysM domain
CVT27_RS30980	COG0784	Response regulator, receiver
CVT27_RS30985	COG4251	negative regulation of phosphorylation
CVT27_RS30990	COG2201	protein-glutamate methylesterase activity
CVT27_RS30995	COG1191	sigma factor activity
CVT27_RS31035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVT27_RS31055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVT27_RS31060	COG3275	phosphorelay sensor kinase activity
CVT27_RS31135	COG0583	DNA-binding transcription factor activity
CVT27_RS31145	COG1053	succinate dehydrogenase
CVT27_RS31150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVT27_RS31165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVT27_RS31170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVT27_RS31180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS31185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVT27_RS31190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVT27_RS31220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVT27_RS31230	COG2197	response regulator
CVT27_RS31235	COG2423	ornithine cyclodeaminase activity
CVT27_RS31240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVT27_RS31255	COG3360	Dodecin
CVT27_RS31275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CVT27_RS31280	COG0121	glutamine amidotransferase
CVT27_RS31285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVT27_RS31290	COG3572	ergothioneine biosynthetic process
CVT27_RS31315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVT27_RS31320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVT27_RS31325	COG1834	amidinotransferase
CVT27_RS31340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVT27_RS31355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVT27_RS31380	COG1028	Short-chain dehydrogenase reductase Sdr
CVT27_RS31410	COG0243	molybdopterin cofactor binding
CVT27_RS31440	COG0747	negative chemotaxis
CVT27_RS31445	COG0601	transmembrane transport
CVT27_RS31450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS31455	COG0444	Belongs to the ABC transporter superfamily
CVT27_RS31460	COG4608	Belongs to the ABC transporter superfamily
CVT27_RS31465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVT27_RS31470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVT27_RS31480	COG0431	NADPH-dependent FMN reductase
CVT27_RS31530	COG1120	ATPase activity
CVT27_RS31540	COG0477	Major facilitator Superfamily
CVT27_RS31545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVT27_RS31555	COG0254	rRNA binding
CVT27_RS31560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVT27_RS31565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVT27_RS31570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVT27_RS31590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS31595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS31600	COG1120	ATPase activity
CVT27_RS31625	COG1132	(ABC) transporter
CVT27_RS31630	COG1132	(ABC) transporter
CVT27_RS31675	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS31700	COG0297	glycogen (starch) synthase activity
CVT27_RS31700	COG0438	transferase activity, transferring glycosyl groups
CVT27_RS31740	COG1174	glycine betaine transport
CVT27_RS31745	COG1174	glycine betaine transport
CVT27_RS31765	COG0517	IMP dehydrogenase activity
CVT27_RS31765	COG1125	glycine betaine transport
CVT27_RS31775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVT27_RS31795	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS31800	COG1960	acyl-CoA dehydrogenase activity
CVT27_RS31815	COG0601	transmembrane transport
CVT27_RS31820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVT27_RS31825	COG0444	Belongs to the ABC transporter superfamily
CVT27_RS31890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CVT27_RS31890	COG1796	DNA polymerase
CVT27_RS31975	COG1278	Cold shock
CVT27_RS31990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CVT27_RS32010	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CVT27_RS32050	COG5297	Belongs to the glycosyl hydrolase family 6
CVT27_RS32060	COG3300	MHYT domain
CVT27_RS32060	COG5001	Diguanylate cyclase
CVT27_RS32075	COG2146	nitrite reductase [NAD(P)H] activity
CVT27_RS32075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVT27_RS32080	COG2146	nitrite reductase [NAD(P)H] activity
CVT27_RS32080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVT27_RS32085	COG0243	molybdopterin cofactor binding
CVT27_RS32090	COG2223	nitrite transmembrane transporter activity
CVT27_RS32145	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CVT27_RS32175	COG0745	RESPONSE REGULATOR receiver
CVT27_RS32185	COG1120	ATPase activity
CVT27_RS32225	COG4585	Histidine kinase
CVT27_RS32230	COG2197	response regulator
CVT27_RS32240	COG1136	(ABC) transporter
CVT27_RS32240	COG0577	efflux transmembrane transporter activity
CVT27_RS32260	COG1012	belongs to the aldehyde dehydrogenase family
CVT27_RS32280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVT27_RS32285	COG3239	Fatty acid desaturase
CVT27_RS32305	COG2267	carboxylic ester hydrolase activity
CVT27_RS32320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVT27_RS32325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CVT27_RS32330	COG0640	Transcriptional regulator
CVT27_RS32345	COG2018	Roadblock/LC7 domain
CVT27_RS32375	COG1024	Enoyl-CoA hydratase
CVT27_RS32415	COG1595	DNA-templated transcription, initiation
CVT27_RS32430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVT27_RS32435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVT27_RS32445	COG2340	Cysteine-rich secretory protein family
CVT27_RS32475	COG0488	(ABC) transporter
CVT27_RS32490	COG0009	L-threonylcarbamoyladenylate synthase
CVT27_RS32525	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CVT27_RS32545	COG0142	geranyltranstransferase activity
CVT27_RS32550	COG3250	beta-galactosidase activity
CVT27_RS32550	COG5297	Belongs to the glycosyl hydrolase family 6
CVT27_RS32565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CVT27_RS32580	COG1891	lyase activity
CVT27_RS32590	COG2890	protein-(glutamine-N5) methyltransferase activity
CVT27_RS32625	COG1175	transmembrane transport
CVT27_RS32630	COG0395	ABC-type sugar transport system, permease component
CVT27_RS32635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVT27_RS32640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVT27_RS32650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVT27_RS32675	COG2367	Beta-lactamase
CVT27_RS32730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVT27_RS32735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVT27_RS32745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form