locus-tag	class	description
NF554_RS00020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NF554_RS00030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NF554_RS00035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS00085	COG2367	Beta-lactamase
NF554_RS00110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NF554_RS00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NF554_RS00130	COG0395	ABC-type sugar transport system, permease component
NF554_RS00135	COG1175	transmembrane transport
NF554_RS00175	COG2890	protein-(glutamine-N5) methyltransferase activity
NF554_RS00185	COG1891	lyase activity
NF554_RS00200	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NF554_RS00215	COG5297	Belongs to the glycosyl hydrolase family 6
NF554_RS00215	COG3250	beta-galactosidase activity
NF554_RS00220	COG0142	geranyltranstransferase activity
NF554_RS00240	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NF554_RS00275	COG0009	L-threonylcarbamoyladenylate synthase
NF554_RS00330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NF554_RS00335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NF554_RS00350	COG1595	DNA-templated transcription, initiation
NF554_RS00390	COG1024	Enoyl-CoA hydratase
NF554_RS00415	COG2018	Roadblock/LC7 domain
NF554_RS00430	COG0640	Transcriptional regulator
NF554_RS00435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NF554_RS00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NF554_RS00455	COG2267	carboxylic ester hydrolase activity
NF554_RS00475	COG3239	Fatty acid desaturase
NF554_RS00480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NF554_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS00520	COG0577	efflux transmembrane transporter activity
NF554_RS00520	COG1136	(ABC) transporter
NF554_RS00530	COG2197	response regulator
NF554_RS00535	COG4585	Histidine kinase
NF554_RS00580	COG1120	ATPase activity
NF554_RS00595	COG0745	RESPONSE REGULATOR receiver
NF554_RS00625	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NF554_RS00680	COG2223	nitrite transmembrane transporter activity
NF554_RS00690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NF554_RS00690	COG2146	nitrite reductase [NAD(P)H] activity
NF554_RS00700	COG2146	nitrite reductase [NAD(P)H] activity
NF554_RS00700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NF554_RS00715	COG5001	Diguanylate cyclase
NF554_RS00715	COG3300	MHYT domain
NF554_RS00725	COG5297	Belongs to the glycosyl hydrolase family 6
NF554_RS00765	COG4044	May play a role in the intracellular transport of hydrophobic ligands
NF554_RS00785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NF554_RS00800	COG1278	Cold shock
NF554_RS00885	COG1796	DNA polymerase
NF554_RS00885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NF554_RS00955	COG0444	Belongs to the ABC transporter superfamily
NF554_RS00960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS00965	COG0601	transmembrane transport
NF554_RS00980	COG1960	acyl-CoA dehydrogenase activity
NF554_RS01005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NF554_RS01015	COG0517	IMP dehydrogenase activity
NF554_RS01015	COG1125	glycine betaine transport
NF554_RS01035	COG1174	glycine betaine transport
NF554_RS01040	COG1174	glycine betaine transport
NF554_RS01080	COG0438	transferase activity, transferring glycosyl groups
NF554_RS01080	COG0297	glycogen (starch) synthase activity
NF554_RS01150	COG1132	(ABC) transporter
NF554_RS01185	COG1120	ATPase activity
NF554_RS01190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS01195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS01215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NF554_RS01220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NF554_RS01225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NF554_RS01230	COG0254	rRNA binding
NF554_RS01240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NF554_RS01245	COG0477	Major facilitator Superfamily
NF554_RS01255	COG1120	ATPase activity
NF554_RS01305	COG0431	NADPH-dependent FMN reductase
NF554_RS01315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NF554_RS01320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS01325	COG4608	Belongs to the ABC transporter superfamily
NF554_RS01330	COG0444	Belongs to the ABC transporter superfamily
NF554_RS01335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS01340	COG0601	transmembrane transport
NF554_RS01345	COG0747	negative chemotaxis
NF554_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS01440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NF554_RS01455	COG1834	amidinotransferase
NF554_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NF554_RS01490	COG3572	ergothioneine biosynthetic process
NF554_RS01495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NF554_RS01500	COG0121	glutamine amidotransferase
NF554_RS01525	COG3360	Dodecin
NF554_RS01540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NF554_RS01545	COG2423	ornithine cyclodeaminase activity
NF554_RS01550	COG2197	response regulator
NF554_RS01560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NF554_RS01590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS01595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NF554_RS01600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS01610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NF554_RS01615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NF554_RS01630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NF554_RS01635	COG1053	succinate dehydrogenase
NF554_RS01720	COG3275	phosphorelay sensor kinase activity
NF554_RS01725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NF554_RS01745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NF554_RS01795	COG2201	protein-glutamate methylesterase activity
NF554_RS01800	COG4251	negative regulation of phosphorylation
NF554_RS01805	COG0784	Response regulator, receiver
NF554_RS01840	COG1652	LysM domain
NF554_RS01850	COG1940	carbohydrate kinase activity
NF554_RS01860	COG1175	transmembrane transport
NF554_RS01865	COG0395	ABC-type sugar transport system, permease component
NF554_RS01875	COG0596	Alpha beta hydrolase
NF554_RS01920	COG2837	iron assimilation
NF554_RS01930	COG0019	diaminopimelate decarboxylase activity
NF554_RS01945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NF554_RS01955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NF554_RS01970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NF554_RS01975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NF554_RS01980	COG2080	2 iron, 2 sulfur cluster binding
NF554_RS02000	COG2130	NADP-dependent
NF554_RS02005	COG1233	COG1233 Phytoene dehydrogenase and related
NF554_RS02060	COG1846	Transcriptional regulator
NF554_RS02065	COG2409	Drug exporters of the RND superfamily
NF554_RS02130	COG0829	nickel cation binding
NF554_RS02135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NF554_RS02140	COG0830	nickel cation binding
NF554_RS02145	COG0804	urea catabolic process
NF554_RS02150	COG0831	urea catabolic process
NF554_RS02150	COG0832	Belongs to the urease beta subunit family
NF554_RS02160	COG0831	urea catabolic process
NF554_RS02220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NF554_RS02230	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NF554_RS02240	COG1316	TRANSCRIPTIONal
NF554_RS02275	COG2079	MmgE PrpD family protein
NF554_RS02280	COG3800	Transcriptional regulator
NF554_RS02280	COG1396	sequence-specific DNA binding
NF554_RS02305	COG3629	intracellular signal transduction
NF554_RS02305	COG3903	Transcriptional regulator
NF554_RS02330	COG1250	3-hydroxyacyl-CoA dehydrogenase
NF554_RS02335	COG0604	alcohol dehydrogenase
NF554_RS02335	COG3321	synthase
NF554_RS02350	COG0604	alcohol dehydrogenase
NF554_RS02350	COG3321	synthase
NF554_RS02370	COG0156	8-amino-7-oxononanoate synthase activity
NF554_RS02380	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS02390	COG1672	PFAM Archaeal ATPase
NF554_RS02390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NF554_RS02410	COG1556	Lactate utilization protein
NF554_RS02415	COG1139	Iron-sulfur cluster binding protein
NF554_RS02420	COG0247	lactate metabolic process
NF554_RS02430	COG3851	Histidine kinase
NF554_RS02435	COG2197	response regulator
NF554_RS02470	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS02490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS02505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS02520	COG1960	acyl-CoA dehydrogenase activity
NF554_RS02545	COG1215	transferase activity, transferring glycosyl groups
NF554_RS02585	COG0456	acetyltransferase
NF554_RS02585	COG1846	Transcriptional regulator
NF554_RS02615	COG3958	Transketolase
NF554_RS02645	COG1116	anion transmembrane transporter activity
NF554_RS02655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NF554_RS02660	COG1609	Transcriptional regulator
NF554_RS02700	COG3467	pyridoxamine 5'-phosphate
NF554_RS02750	COG2755	lipolytic protein G-D-S-L family
NF554_RS02760	COG2365	Tyrosine phosphatase family
NF554_RS02790	COG1657	PFAM Prenyltransferase squalene oxidase
NF554_RS02800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NF554_RS02810	COG1562	ergosterol biosynthetic process
NF554_RS02815	COG1134	teichoic acid transport
NF554_RS02815	COG1388	LysM domain
NF554_RS02830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NF554_RS02860	COG2226	methyltransferase
NF554_RS02865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NF554_RS02880	COG1024	Enoyl-CoA hydratase
NF554_RS02890	COG4977	sequence-specific DNA binding
NF554_RS02900	COG2183	response to ionizing radiation
NF554_RS02905	COG0488	(ABC) transporter
NF554_RS02925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NF554_RS02950	COG0789	Transcriptional regulator
NF554_RS02960	COG0183	Belongs to the thiolase family
NF554_RS02965	COG1960	acyl-CoA dehydrogenase activity
NF554_RS02970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NF554_RS02975	COG3268	Saccharopine dehydrogenase
NF554_RS02985	COG1515	deoxyribonuclease V activity
NF554_RS03000	COG0488	(ABC) transporter
NF554_RS03005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NF554_RS03080	COG1793	dna ligase
NF554_RS03100	COG2208	phosphoserine phosphatase activity
NF554_RS03100	COG2770	Histidine kinase
NF554_RS03160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NF554_RS03215	COG3012	SEC-C Motif Domain Protein
NF554_RS03255	COG1486	melibiose metabolic process
NF554_RS03260	COG2124	cytochrome p450
NF554_RS03285	COG1846	Transcriptional regulator
NF554_RS03310	COG1940	carbohydrate kinase activity
NF554_RS03325	COG1070	Carbohydrate kinase
NF554_RS03340	COG0569	domain protein
NF554_RS03340	COG2985	domain, Protein
NF554_RS03345	COG2124	cytochrome p450
NF554_RS03355	COG4176	ABC-type proline glycine betaine transport system permease component
NF554_RS03360	COG4175	Glycine betaine
NF554_RS03360	COG0517	IMP dehydrogenase activity
NF554_RS03370	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS03400	COG0745	RESPONSE REGULATOR receiver
NF554_RS03405	COG5002	protein histidine kinase activity
NF554_RS03430	COG1869	D-ribose catabolic process
NF554_RS03435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NF554_RS03445	COG1129	ABC transporter
NF554_RS03525	COG0673	inositol 2-dehydrogenase activity
NF554_RS03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
NF554_RS03540	COG1129	ABC transporter
NF554_RS03550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS03555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NF554_RS03570	COG0583	DNA-binding transcription factor activity
NF554_RS03580	COG0656	L-ascorbic acid biosynthetic process
NF554_RS03590	COG4106	trans-aconitate 2-methyltransferase activity
NF554_RS03600	COG2154	pterin-4-alpha-carbinolamine dehydratase
NF554_RS03625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NF554_RS03625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NF554_RS03640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NF554_RS03665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NF554_RS03685	COG4106	trans-aconitate 2-methyltransferase activity
NF554_RS03700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NF554_RS03715	COG1619	proteins homologs of microcin C7 resistance protein MccF
NF554_RS03730	COG2362	D-Aminopeptidase
NF554_RS03740	COG0667	Aldo Keto reductase
NF554_RS03775	COG1250	3-hydroxyacyl-CoA dehydrogenase
NF554_RS03795	COG0604	alcohol dehydrogenase
NF554_RS03800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS03800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS03805	COG2301	Belongs to the HpcH HpaI aldolase family
NF554_RS03815	COG1960	acyl-CoA dehydrogenase activity
NF554_RS03820	COG0688	phosphatidylethanolamine metabolic process
NF554_RS03850	COG0559	Belongs to the binding-protein-dependent transport system permease family
NF554_RS03855	COG0559	Belongs to the binding-protein-dependent transport system permease family
NF554_RS03875	COG1929	Belongs to the glycerate kinase type-1 family
NF554_RS03890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NF554_RS03940	COG1024	Enoyl-CoA hydratase
NF554_RS03945	COG1131	(ABC) transporter
NF554_RS03955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS03970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS04010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS04015	COG1024	Enoyl-CoA hydratase
NF554_RS04060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NF554_RS04095	COG1960	acyl-CoA dehydrogenase activity
NF554_RS04100	COG1024	Enoyl-CoA hydratase
NF554_RS04115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NF554_RS04120	COG0095	Lipoate-protein ligase
NF554_RS04130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NF554_RS04140	COG2838	Isocitrate dehydrogenase
NF554_RS04165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NF554_RS04170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NF554_RS04180	COG0667	Aldo Keto reductase
NF554_RS04210	COG0405	Gamma-glutamyltransferase
NF554_RS04225	COG1376	ErfK ybiS ycfS ynhG family protein
NF554_RS04235	COG0765	amino acid transport
NF554_RS04240	COG0765	amino acid transport
NF554_RS04245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS04250	COG1126	abc transporter atp-binding protein
NF554_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS04300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NF554_RS04305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NF554_RS04315	COG1940	carbohydrate kinase activity
NF554_RS04320	COG1129	ABC transporter
NF554_RS04335	COG2188	Transcriptional regulator
NF554_RS04340	COG0673	inositol 2-dehydrogenase activity
NF554_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS04420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NF554_RS04425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NF554_RS04435	COG2271	Major facilitator Superfamily
NF554_RS04490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NF554_RS04490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NF554_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS04525	COG4266	Belongs to the allantoicase family
NF554_RS04530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NF554_RS04555	COG2197	response regulator
NF554_RS04570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NF554_RS04615	COG2233	PERMEase
NF554_RS04625	COG2233	PERMEase
NF554_RS04635	COG2351	hydroxyisourate hydrolase activity
NF554_RS04655	COG2188	Transcriptional regulator
NF554_RS04665	COG1175	transmembrane transport
NF554_RS04670	COG0395	ABC-type sugar transport system, permease component
NF554_RS04680	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NF554_RS04685	COG3622	Belongs to the hyi family
NF554_RS04690	COG2084	Dehydrogenase
NF554_RS04695	COG0753	catalase activity
NF554_RS04710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NF554_RS04715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NF554_RS04725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NF554_RS04735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS04745	COG3903	Transcriptional regulator
NF554_RS04745	COG3629	intracellular signal transduction
NF554_RS04760	COG3960	tartronate-semialdehyde synthase activity
NF554_RS04780	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS04785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NF554_RS04790	COG2197	response regulator
NF554_RS04830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS04855	COG3608	succinylglutamate desuccinylase aspartoacylase
NF554_RS04855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NF554_RS04860	COG2252	PERMEase
NF554_RS04865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NF554_RS04890	COG1802	Transcriptional regulator
NF554_RS04910	COG0028	Belongs to the TPP enzyme family
NF554_RS04925	COG1404	Belongs to the peptidase S8 family
NF554_RS04945	COG1162	GTPase activity
NF554_RS04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NF554_RS04995	COG0183	Belongs to the thiolase family
NF554_RS05000	COG0583	DNA-binding transcription factor activity
NF554_RS05005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NF554_RS05010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NF554_RS05035	COG1960	acyl-CoA dehydrogenase activity
NF554_RS05060	COG0175	sulfate reduction
NF554_RS05065	COG0529	Catalyzes the synthesis of activated sulfate
NF554_RS05085	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NF554_RS05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NF554_RS05110	COG1132	(ABC) transporter
NF554_RS05115	COG1132	(ABC) transporter
NF554_RS05130	COG1404	Belongs to the peptidase S8 family
NF554_RS05150	COG1175	transmembrane transport
NF554_RS05205	COG2723	6-phospho-beta-galactosidase activity
NF554_RS05225	COG0346	lactoylglutathione lyase activity
NF554_RS05235	COG0583	DNA-binding transcription factor activity
NF554_RS05240	COG0156	8-amino-7-oxononanoate synthase activity
NF554_RS05245	COG1063	alcohol dehydrogenase
NF554_RS05250	COG0515	serine threonine protein kinase
NF554_RS05250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NF554_RS05280	COG1100	Small GTP-binding protein
NF554_RS05320	COG0483	inositol monophosphate 1-phosphatase activity
NF554_RS05350	COG2072	flavoprotein involved in K transport
NF554_RS05390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NF554_RS05395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NF554_RS05435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NF554_RS05445	COG2376	Dihydroxyacetone kinase
NF554_RS05485	COG3253	May function as heme-dependent peroxidase
NF554_RS05490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NF554_RS05505	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NF554_RS05525	COG0183	Belongs to the thiolase family
NF554_RS05530	COG1250	3-hydroxyacyl-CoA dehydrogenase
NF554_RS05530	COG1024	Enoyl-CoA hydratase
NF554_RS05535	COG1316	TRANSCRIPTIONal
NF554_RS05545	COG0531	amino acid
NF554_RS05550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NF554_RS05555	COG4214	carbohydrate transport
NF554_RS05565	COG4213	ABC transporter substrate-binding protein
NF554_RS05570	COG1940	carbohydrate kinase activity
NF554_RS05575	COG0395	ABC-type sugar transport system, permease component
NF554_RS05580	COG1175	transmembrane transport
NF554_RS05585	COG1653	transport
NF554_RS05595	COG0406	alpha-ribazole phosphatase activity
NF554_RS05610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NF554_RS05620	COG2267	carboxylic ester hydrolase activity
NF554_RS05635	COG0515	serine threonine protein kinase
NF554_RS05635	COG2815	serine threonine protein kinase
NF554_RS05665	COG3629	intracellular signal transduction
NF554_RS05665	COG3903	Transcriptional regulator
NF554_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS05710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NF554_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NF554_RS05720	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NF554_RS05755	COG0489	protein tyrosine kinase activity
NF554_RS05775	COG1320	monovalent cation:proton antiporter activity
NF554_RS05790	COG0651	ATP synthesis coupled electron transport
NF554_RS05795	COG1006	Multisubunit Na H antiporter MnhC subunit
NF554_RS05805	COG2111	Na H antiporter
NF554_RS05805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NF554_RS05810	COG0251	oxidation-reduction process
NF554_RS05835	COG1024	Enoyl-CoA hydratase
NF554_RS05845	COG0531	amino acid
NF554_RS05850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NF554_RS05860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NF554_RS05870	COG2040	homocysteine
NF554_RS05890	COG1799	cell septum assembly
NF554_RS05900	COG0586	Pfam SNARE associated Golgi protein
NF554_RS05915	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS05920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS05945	COG3835	regulator
NF554_RS05950	COG1802	Transcriptional regulator
NF554_RS05955	COG3938	Belongs to the proline racemase family
NF554_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NF554_RS05995	COG1280	lysine exporter protein (LysE YggA)
NF554_RS06000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NF554_RS06005	COG0505	Belongs to the CarA family
NF554_RS06105	COG1674	ftsk spoiiie
NF554_RS06115	COG0464	growth
NF554_RS06140	COG0596	Alpha beta hydrolase
NF554_RS06160	COG4585	Histidine kinase
NF554_RS06210	COG0515	serine threonine protein kinase
NF554_RS06210	COG2815	serine threonine protein kinase
NF554_RS06260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NF554_RS06270	COG0569	domain protein
NF554_RS06305	COG0756	dUTP diphosphatase activity
NF554_RS06330	COG2205	protein histidine kinase activity
NF554_RS06335	COG0745	RESPONSE REGULATOR receiver
NF554_RS06345	COG0483	inositol monophosphate 1-phosphatase activity
NF554_RS06350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NF554_RS06385	COG1435	thymidine kinase activity
NF554_RS06400	COG0045	succinate-CoA ligase (ADP-forming) activity
NF554_RS06400	COG1042	CoA-binding domain protein
NF554_RS06400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NF554_RS06405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NF554_RS06410	COG1802	Transcriptional regulator
NF554_RS06415	COG0739	heme binding
NF554_RS06425	COG0612	Peptidase, M16
NF554_RS06430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NF554_RS06440	COG0372	Belongs to the citrate synthase family
NF554_RS06455	COG3290	protein histidine kinase activity
NF554_RS06460	COG4565	transcriptional regulatory protein
NF554_RS06465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NF554_RS06490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NF554_RS06495	COG2186	Transcriptional regulator
NF554_RS06500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NF554_RS06515	COG1309	transcriptional regulator
NF554_RS06520	COG3848	Pyruvate phosphate dikinase
NF554_RS06520	COG0574	Belongs to the PEP-utilizing enzyme family
NF554_RS06525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NF554_RS06540	COG2814	Major facilitator Superfamily
NF554_RS06565	COG0514	ATP-dependent DNA helicase (RecQ)
NF554_RS06580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NF554_RS06615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NF554_RS06620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NF554_RS06625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NF554_RS06665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NF554_RS06675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NF554_RS06680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NF554_RS06690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NF554_RS06705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NF554_RS06710	COG2358	TRAP transporter, solute receptor (TAXI family
NF554_RS06715	COG2205	protein histidine kinase activity
NF554_RS06720	COG0745	RESPONSE REGULATOR receiver
NF554_RS06725	COG1126	abc transporter atp-binding protein
NF554_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS06735	COG0765	amino acid transport
NF554_RS06740	COG0765	amino acid transport
NF554_RS06770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NF554_RS06780	COG1672	PFAM Archaeal ATPase
NF554_RS06780	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NF554_RS06800	COG2197	response regulator
NF554_RS06805	COG1271	oxidase subunit
NF554_RS06810	COG1271	oxidase subunit
NF554_RS06845	COG1917	Cupin 2, conserved barrel domain protein
NF554_RS06845	COG2207	Transcriptional regulator
NF554_RS06855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NF554_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS06870	COG0783	Belongs to the Dps family
NF554_RS06875	COG1396	sequence-specific DNA binding
NF554_RS06880	COG1058	Belongs to the CinA family
NF554_RS06880	COG1546	Belongs to the CinA family
NF554_RS06890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NF554_RS06900	COG1674	ftsk spoiiie
NF554_RS06915	COG2208	phosphoserine phosphatase activity
NF554_RS06915	COG2770	Histidine kinase
NF554_RS06940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NF554_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NF554_RS06950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NF554_RS06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NF554_RS06975	COG0612	Peptidase, M16
NF554_RS06980	COG1185	polyribonucleotide nucleotidyltransferase activity
NF554_RS06985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NF554_RS06995	COG1674	ftsk spoiiie
NF554_RS07025	COG1404	Belongs to the peptidase S8 family
NF554_RS07030	COG3266	domain, Protein
NF554_RS07050	COG0455	bacterial-type flagellum organization
NF554_RS07055	COG0747	negative chemotaxis
NF554_RS07060	COG0601	transmembrane transport
NF554_RS07065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS07110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NF554_RS07115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NF554_RS07125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NF554_RS07140	COG0779	Required for maturation of 30S ribosomal subunits
NF554_RS07160	COG0442	prolyl-tRNA aminoacylation
NF554_RS07175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NF554_RS07180	COG0750	zinc metalloprotease
NF554_RS07185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NF554_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS07235	COG1177	transmembrane transport
NF554_RS07240	COG1176	ABC-type spermidine putrescine transport system, permease component I
NF554_RS07245	COG3842	ATPase activity
NF554_RS07250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NF554_RS07270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NF554_RS07295	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS07305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NF554_RS07310	COG1136	(ABC) transporter
NF554_RS07325	COG3842	ATPase activity
NF554_RS07340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NF554_RS07350	COG0233	cytoplasmic translational termination
NF554_RS07355	COG0528	UMP kinase activity
NF554_RS07360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NF554_RS07365	COG0052	Belongs to the universal ribosomal protein uS2 family
NF554_RS07380	COG1191	sigma factor activity
NF554_RS07395	COG0792	nuclease activity
NF554_RS07410	COG0681	Belongs to the peptidase S26 family
NF554_RS07415	COG0681	Belongs to the peptidase S26 family
NF554_RS07430	COG0335	large ribosomal subunit rRNA binding
NF554_RS07435	COG0336	Belongs to the RNA methyltransferase TrmD family
NF554_RS07440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NF554_RS07445	COG1837	Belongs to the UPF0109 family
NF554_RS07450	COG0228	four-way junction DNA binding
NF554_RS07470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NF554_RS07505	COG0477	Major facilitator Superfamily
NF554_RS07520	COG1254	Belongs to the acylphosphatase family
NF554_RS07525	COG2340	Cysteine-rich secretory protein family
NF554_RS07530	COG1733	regulation of RNA biosynthetic process
NF554_RS07535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NF554_RS07540	COG0571	ribonuclease III activity
NF554_RS07545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NF554_RS07560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NF554_RS07565	COG0742	ribosomal rna small subunit methyltransferase
NF554_RS07570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NF554_RS07575	COG1461	Dihydroxyacetone kinase
NF554_RS07580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NF554_RS07585	COG0351	phosphomethylpyrimidine kinase
NF554_RS07600	COG1181	Belongs to the D-alanine--D-alanine ligase family
NF554_RS07605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NF554_RS07615	COG1920	GTP binding
NF554_RS07625	COG0776	regulation of translation
NF554_RS07635	COG0066	3-isopropylmalate dehydratase activity
NF554_RS07640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NF554_RS07645	COG1414	Transcriptional regulator
NF554_RS07680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NF554_RS07685	COG0179	Fumarylacetoacetate (FAA) hydrolase
NF554_RS07695	COG5002	protein histidine kinase activity
NF554_RS07700	COG2018	Roadblock/LC7 domain
NF554_RS07720	COG2018	Roadblock/LC7 domain
NF554_RS07770	COG4607	ABC-type enterochelin transport system periplasmic component
NF554_RS07775	COG1120	ATPase activity
NF554_RS07780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS07785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS07810	COG1733	regulation of RNA biosynthetic process
NF554_RS07830	COG0492	ferredoxin-NADP+ reductase activity
NF554_RS07855	COG3708	Transcriptional regulator
NF554_RS07855	COG2207	Transcriptional regulator
NF554_RS07875	COG1472	Belongs to the glycosyl hydrolase 3 family
NF554_RS07885	COG0444	Belongs to the ABC transporter superfamily
NF554_RS07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS07895	COG0601	transmembrane transport
NF554_RS07900	COG4608	Belongs to the ABC transporter superfamily
NF554_RS07915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NF554_RS07925	COG2957	Belongs to the agmatine deiminase family
NF554_RS07930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NF554_RS07935	COG0473	3-isopropylmalate dehydrogenase activity
NF554_RS07945	COG2130	NADP-dependent
NF554_RS07960	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS07965	COG0506	proline dehydrogenase activity
NF554_RS07970	COG2508	Transcriptional regulator
NF554_RS07995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NF554_RS08000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NF554_RS08005	COG0440	acetolactate synthase activity
NF554_RS08025	COG0667	Aldo Keto reductase
NF554_RS08030	COG2133	pyrroloquinoline quinone binding
NF554_RS08045	COG2409	Drug exporters of the RND superfamily
NF554_RS08055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NF554_RS08060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NF554_RS08070	COG0154	amidase activity
NF554_RS08075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NF554_RS08085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NF554_RS08095	COG4221	oxidoreductase activity
NF554_RS08115	COG0482	sulfurtransferase activity
NF554_RS08150	COG2860	membrane
NF554_RS08155	COG4608	Belongs to the ABC transporter superfamily
NF554_RS08165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS08170	COG0601	transmembrane transport
NF554_RS08175	COG4166	transmembrane transport
NF554_RS08195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NF554_RS08200	COG0509	glycine decarboxylation via glycine cleavage system
NF554_RS08205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NF554_RS08220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NF554_RS08235	COG2235	arginine
NF554_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS08410	COG0477	Major facilitator Superfamily
NF554_RS08455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NF554_RS08460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NF554_RS08465	COG0142	geranyltranstransferase activity
NF554_RS08470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NF554_RS08535	COG2197	response regulator
NF554_RS08560	COG1132	(ABC) transporter
NF554_RS08585	COG0058	SHG alpha-glucan phosphorylase activity
NF554_RS08590	COG0366	Alpha amylase catalytic
NF554_RS08595	COG0366	Alpha amylase catalytic
NF554_RS08600	COG3281	Trehalose synthase
NF554_RS08605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NF554_RS08610	COG1301	dicarboxylic acid transport
NF554_RS08615	COG3290	protein histidine kinase activity
NF554_RS08620	COG4565	transcriptional regulatory protein
NF554_RS08630	COG0205	6-phosphofructokinase activity
NF554_RS08640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NF554_RS08675	COG1597	lipid kinase activity
NF554_RS08680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS08680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS08755	COG5002	protein histidine kinase activity
NF554_RS08760	COG0745	RESPONSE REGULATOR receiver
NF554_RS08775	COG3209	COG3209 Rhs family protein
NF554_RS08775	COG4104	PAAR repeat-containing protein
NF554_RS08790	COG0183	Belongs to the thiolase family
NF554_RS08845	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
NF554_RS08860	COG1250	3-hydroxyacyl-CoA dehydrogenase
NF554_RS08880	COG2197	response regulator
NF554_RS08895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NF554_RS08900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NF554_RS08905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NF554_RS08910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NF554_RS08915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NF554_RS08920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NF554_RS08925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NF554_RS08945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NF554_RS08950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NF554_RS08960	COG2890	protein-(glutamine-N5) methyltransferase activity
NF554_RS08965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NF554_RS08970	COG0254	rRNA binding
NF554_RS08975	COG1316	TRANSCRIPTIONal
NF554_RS08985	COG0083	homoserine kinase activity
NF554_RS08990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NF554_RS08995	COG0460	homoserine dehydrogenase
NF554_RS09000	COG0019	diaminopimelate decarboxylase activity
NF554_RS09030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NF554_RS09035	COG3285	dna ligase
NF554_RS09035	COG1793	dna ligase
NF554_RS09055	COG2205	protein histidine kinase activity
NF554_RS09070	COG0768	penicillin binding
NF554_RS09190	COG0726	polysaccharide deacetylase
NF554_RS09195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NF554_RS09235	COG0745	RESPONSE REGULATOR receiver
NF554_RS09240	COG2205	protein histidine kinase activity
NF554_RS09245	COG0567	Dehydrogenase, E1 component
NF554_RS09245	COG0508	dehydrogenase complex catalyzes the overall conversion of
NF554_RS09270	COG0542	response to heat
NF554_RS09285	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NF554_RS09290	COG0604	alcohol dehydrogenase
NF554_RS09295	COG0281	malic enzyme
NF554_RS09300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS09305	COG0765	amino acid transport
NF554_RS09310	COG1126	abc transporter atp-binding protein
NF554_RS09315	COG4106	trans-aconitate 2-methyltransferase activity
NF554_RS09400	COG0142	geranyltranstransferase activity
NF554_RS09405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NF554_RS09410	COG1959	2 iron, 2 sulfur cluster binding
NF554_RS09415	COG1017	nitric oxide dioxygenase activity
NF554_RS09415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NF554_RS09455	COG2172	sigma factor antagonist activity
NF554_RS09470	COG1597	lipid kinase activity
NF554_RS09485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NF554_RS09495	COG1472	Belongs to the glycosyl hydrolase 3 family
NF554_RS09500	COG0395	ABC-type sugar transport system, permease component
NF554_RS09505	COG1175	transmembrane transport
NF554_RS09510	COG2182	Extracellular solute-binding protein
NF554_RS09520	COG1966	Carbon starvation protein
NF554_RS09630	COG0242	peptide deformylase activity
NF554_RS09645	COG5662	AntiSigma factor
NF554_RS09650	COG1595	DNA-templated transcription, initiation
NF554_RS09660	COG2135	peptidase activity
NF554_RS09670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NF554_RS09675	COG1162	GTPase activity
NF554_RS09680	COG2076	Multidrug Resistance protein
NF554_RS09690	COG0483	inositol monophosphate 1-phosphatase activity
NF554_RS09700	COG0753	catalase activity
NF554_RS09735	COG1615	UPF0182 protein
NF554_RS09745	COG3480	Lon protease (S16) C-terminal proteolytic domain
NF554_RS09795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NF554_RS09900	COG4172	Belongs to the ABC transporter superfamily
NF554_RS09905	COG0601	transmembrane transport
NF554_RS09910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS09915	COG0747	negative chemotaxis
NF554_RS09955	COG0513	Belongs to the DEAD box helicase family
NF554_RS09970	COG1432	Conserved Protein
NF554_RS09980	COG2095	MarC family integral membrane protein
NF554_RS10035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NF554_RS10040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NF554_RS10050	COG1595	DNA-templated transcription, initiation
NF554_RS10065	COG1024	Enoyl-CoA hydratase
NF554_RS10070	COG0519	Catalyzes the synthesis of GMP from XMP
NF554_RS10080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NF554_RS10085	COG1611	Belongs to the LOG family
NF554_RS10090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NF554_RS10120	COG2912	Transglutaminase-like superfamily
NF554_RS10130	COG1132	(ABC) transporter
NF554_RS10155	COG0110	maltose O-acetyltransferase activity
NF554_RS10175	COG1396	sequence-specific DNA binding
NF554_RS10180	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NF554_RS10195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NF554_RS10225	COG1136	(ABC) transporter
NF554_RS10225	COG0577	efflux transmembrane transporter activity
NF554_RS10240	COG2197	response regulator
NF554_RS10245	COG4608	Belongs to the ABC transporter superfamily
NF554_RS10255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS10260	COG0601	transmembrane transport
NF554_RS10265	COG4166	transmembrane transport
NF554_RS10270	COG4608	Belongs to the ABC transporter superfamily
NF554_RS10275	COG0444	Belongs to the ABC transporter superfamily
NF554_RS10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS10285	COG0601	transmembrane transport
NF554_RS10290	COG0747	negative chemotaxis
NF554_RS10300	COG1217	gtp-binding protein TYPA
NF554_RS10310	COG2226	methyltransferase
NF554_RS10315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NF554_RS10375	COG3795	YCII-related domain
NF554_RS10380	COG4941	Belongs to the sigma-70 factor family
NF554_RS10390	COG0463	Glycosyl transferase, family 2
NF554_RS10400	COG1842	Phage shock protein A
NF554_RS10440	COG0789	Transcriptional regulator
NF554_RS10470	COG0012	GTP binding
NF554_RS10485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NF554_RS10495	COG1570	exodeoxyribonuclease VII activity
NF554_RS10500	COG1722	exodeoxyribonuclease VII activity
NF554_RS10505	COG0778	Nitroreductase
NF554_RS10530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NF554_RS10530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NF554_RS10535	COG1362	aminopeptidase activity
NF554_RS10545	COG0114	fumarate hydratase activity
NF554_RS10560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NF554_RS10560	COG4499	WXG100 protein secretion system (Wss), protein YukC
NF554_RS10580	COG1136	(ABC) transporter
NF554_RS10595	COG0450	alkyl hydroperoxide reductase
NF554_RS10600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NF554_RS10615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NF554_RS10620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NF554_RS10625	COG0667	Aldo Keto reductase
NF554_RS10675	COG2885	chlorophyll binding
NF554_RS10695	COG2197	response regulator
NF554_RS10730	COG2894	cell division
NF554_RS10755	COG2610	gluconate transmembrane transporter activity
NF554_RS10760	COG0251	oxidation-reduction process
NF554_RS10765	COG1414	Transcriptional regulator
NF554_RS10885	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
NF554_RS10925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NF554_RS10935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NF554_RS10950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NF554_RS10955	COG2255	four-way junction helicase activity
NF554_RS10960	COG1366	Belongs to the anti-sigma-factor antagonist family
NF554_RS10965	COG1366	Belongs to the anti-sigma-factor antagonist family
NF554_RS10970	COG2172	sigma factor antagonist activity
NF554_RS10980	COG2202	Pas domain
NF554_RS10980	COG2205	protein histidine kinase activity
NF554_RS10985	COG0745	RESPONSE REGULATOR receiver
NF554_RS10990	COG1595	DNA-templated transcription, initiation
NF554_RS11010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NF554_RS11030	COG1396	sequence-specific DNA binding
NF554_RS11035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NF554_RS11050	COG1376	ErfK ybiS ycfS ynhG family protein
NF554_RS11080	COG1024	Enoyl-CoA hydratase
NF554_RS11095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NF554_RS11105	COG0424	maF-like protein
NF554_RS11115	COG4770	biotin carboxylase activity
NF554_RS11125	COG1349	DNA-binding transcription factor activity
NF554_RS11160	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS11200	COG1595	DNA-templated transcription, initiation
NF554_RS11205	COG0745	RESPONSE REGULATOR receiver
NF554_RS11210	COG2205	protein histidine kinase activity
NF554_RS11235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NF554_RS11250	COG0583	DNA-binding transcription factor activity
NF554_RS11260	COG2814	Major facilitator Superfamily
NF554_RS11300	COG1079	Belongs to the binding-protein-dependent transport system permease family
NF554_RS11305	COG4603	Belongs to the binding-protein-dependent transport system permease family
NF554_RS11310	COG3845	ABC transporter
NF554_RS11315	COG1744	ABC transporter substrate-binding protein PnrA-like
NF554_RS11320	COG1473	amidohydrolase
NF554_RS11320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NF554_RS11330	COG2089	acid synthase
NF554_RS11335	COG1083	cytidylyl-transferase
NF554_RS11345	COG1216	Glycosyl transferase, family 2
NF554_RS11355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NF554_RS11380	COG1595	DNA-templated transcription, initiation
NF554_RS11445	COG2009	succinate dehydrogenase
NF554_RS11455	COG1053	succinate dehydrogenase
NF554_RS11460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NF554_RS11490	COG1408	metallophosphoesterase
NF554_RS11500	COG1686	Belongs to the peptidase S11 family
NF554_RS11505	COG1295	ribonuclease BN
NF554_RS11525	COG0180	Tryptophanyl-tRNA synthetase
NF554_RS11530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NF554_RS11535	COG0754	glutathionylspermidine amidase activity
NF554_RS11545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NF554_RS11550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NF554_RS11560	COG0039	L-malate dehydrogenase activity
NF554_RS11590	COG0138	bifunctional purine biosynthesis protein purh
NF554_RS11620	COG0045	succinate-CoA ligase (ADP-forming) activity
NF554_RS11625	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NF554_RS11630	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NF554_RS11635	COG0714	Associated with various cellular activities
NF554_RS11655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS11655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NF554_RS11690	COG2197	response regulator
NF554_RS11730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NF554_RS11730	COG0519	Catalyzes the synthesis of GMP from XMP
NF554_RS11750	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS11755	COG0515	serine threonine protein kinase
NF554_RS11770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NF554_RS11785	COG0516	GMP reductase activity
NF554_RS11795	COG1595	DNA-templated transcription, initiation
NF554_RS11810	COG0583	DNA-binding transcription factor activity
NF554_RS11820	COG4221	oxidoreductase activity
NF554_RS11830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NF554_RS11835	COG0726	polysaccharide deacetylase
NF554_RS11870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NF554_RS11895	COG0802	atpase or kinase
NF554_RS11905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NF554_RS11910	COG3189	MarR family transcriptional regulator
NF554_RS11920	COG0736	holo-[acyl-carrier-protein] synthase activity
NF554_RS11950	COG4941	Belongs to the sigma-70 factor family
NF554_RS11955	COG0747	negative chemotaxis
NF554_RS11965	COG4566	intracellular signal transduction
NF554_RS11980	COG1072	(Pantothenic acid kinase))
NF554_RS11990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NF554_RS11995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NF554_RS12000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NF554_RS12005	COG0488	(ABC) transporter
NF554_RS12030	COG0101	tRNA pseudouridine synthase activity
NF554_RS12035	COG0203	ribosomal protein L17
NF554_RS12040	COG0202	RNA polymerase activity
NF554_RS12045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NF554_RS12050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NF554_RS12055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NF554_RS12060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NF554_RS12070	COG0563	adenylate kinase activity
NF554_RS12080	COG0200	Binds to the 23S rRNA
NF554_RS12085	COG1841	ribosomal large subunit assembly
NF554_RS12090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NF554_RS12095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NF554_RS12100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NF554_RS12105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NF554_RS12110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NF554_RS12115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NF554_RS12120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NF554_RS12125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NF554_RS12130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NF554_RS12135	COG0255	Belongs to the universal ribosomal protein uL29 family
NF554_RS12140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NF554_RS12145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NF554_RS12150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NF554_RS12155	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NF554_RS12160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NF554_RS12165	COG0089	rRNA binding
NF554_RS12170	COG0088	Forms part of the polypeptide exit tunnel
NF554_RS12175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NF554_RS12180	COG0051	transcription antitermination factor activity, RNA binding
NF554_RS12200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NF554_RS12205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NF554_RS12210	COG0049	tRNA binding
NF554_RS12215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NF554_RS12320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NF554_RS12325	COG0085	RNA polymerase activity
NF554_RS12330	COG0222	ribosome binding
NF554_RS12335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NF554_RS12340	COG0081	regulation of translation
NF554_RS12345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NF554_RS12365	COG0436	Aminotransferase
NF554_RS12370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NF554_RS12385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NF554_RS12395	COG2030	dehydratase
NF554_RS12400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NF554_RS12430	COG1666	GTP binding
NF554_RS12435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NF554_RS12445	COG2261	transglycosylase associated protein
NF554_RS12450	COG3304	Inner membrane component domain
NF554_RS12455	COG0501	Belongs to the peptidase M48B family
NF554_RS12460	COG1970	mechanosensitive ion channel activity
NF554_RS12465	COG1007	ATP synthesis coupled electron transport
NF554_RS12475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NF554_RS12480	COG0713	ATP synthesis coupled electron transport
NF554_RS12485	COG0839	Belongs to the complex I subunit 6 family
NF554_RS12490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NF554_RS12500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NF554_RS12530	COG0674	pyruvate-flavodoxin oxidoreductase activity
NF554_RS12535	COG1013	pyruvate-flavodoxin oxidoreductase activity
NF554_RS12540	COG1733	regulation of RNA biosynthetic process
NF554_RS12545	COG0702	epimerase
NF554_RS12585	COG0561	phosphatase activity
NF554_RS12610	COG1131	(ABC) transporter
NF554_RS12620	COG0142	geranyltranstransferase activity
NF554_RS12625	COG3104	oligopeptide transport
NF554_RS12635	COG0179	Fumarylacetoacetate (FAA) hydrolase
NF554_RS12655	COG1007	ATP synthesis coupled electron transport
NF554_RS12665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NF554_RS12670	COG0713	ATP synthesis coupled electron transport
NF554_RS12675	COG0839	Belongs to the complex I subunit 6 family
NF554_RS12680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NF554_RS12690	COG1034	ATP synthesis coupled electron transport
NF554_RS12695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NF554_RS12705	COG0649	NAD binding
NF554_RS12710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NF554_RS12780	COG2226	methyltransferase
NF554_RS12790	COG2175	clavaminate synthase activity
NF554_RS12800	COG4521	taurine ABC transporter
NF554_RS12805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NF554_RS12815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NF554_RS12825	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NF554_RS12830	COG1278	Cold shock
NF554_RS12870	COG1024	Enoyl-CoA hydratase
NF554_RS12895	COG1309	transcriptional regulator
NF554_RS12905	COG1960	acyl-CoA dehydrogenase activity
NF554_RS12915	COG0259	pyridoxamine-phosphate oxidase activity
NF554_RS12950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS12955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS12960	COG4592	Periplasmic binding protein
NF554_RS12965	COG2072	flavoprotein involved in K transport
NF554_RS13000	COG1024	Enoyl-CoA hydratase
NF554_RS13030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NF554_RS13130	COG1960	acyl-CoA dehydrogenase activity
NF554_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS13150	COG1960	acyl-CoA dehydrogenase activity
NF554_RS13155	COG1960	acyl-CoA dehydrogenase activity
NF554_RS13165	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS13230	COG1595	DNA-templated transcription, initiation
NF554_RS13245	COG0477	Major facilitator Superfamily
NF554_RS13280	COG2267	carboxylic ester hydrolase activity
NF554_RS13290	COG4821	SIS domain
NF554_RS13295	COG2205	protein histidine kinase activity
NF554_RS13300	COG1136	(ABC) transporter
NF554_RS13300	COG0577	efflux transmembrane transporter activity
NF554_RS13310	COG0259	pyridoxamine-phosphate oxidase activity
NF554_RS13335	COG2124	cytochrome p450
NF554_RS13350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NF554_RS13430	COG1024	Enoyl-CoA hydratase
NF554_RS13470	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
NF554_RS13475	COG0494	nUDIX hydrolase
NF554_RS13495	COG3896	Chloramphenicol phosphotransferase-like protein
NF554_RS13500	COG0247	lactate metabolic process
NF554_RS13500	COG0277	FAD linked oxidase domain protein
NF554_RS13505	COG2205	protein histidine kinase activity
NF554_RS13535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NF554_RS13550	COG1302	Protein conserved in bacteria
NF554_RS13570	COG1335	isochorismatase
NF554_RS13625	COG0697	spore germination
NF554_RS13635	COG1309	transcriptional regulator
NF554_RS13655	COG1051	belongs to the nudix hydrolase family
NF554_RS13730	COG0583	DNA-binding transcription factor activity
NF554_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS13745	COG0515	serine threonine protein kinase
NF554_RS13780	COG2267	carboxylic ester hydrolase activity
NF554_RS13785	COG0667	Aldo Keto reductase
NF554_RS13795	COG0697	spore germination
NF554_RS13820	COG2252	PERMEase
NF554_RS13830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NF554_RS13845	COG2814	Major facilitator Superfamily
NF554_RS13855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NF554_RS13860	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NF554_RS13885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS13890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS13895	COG1120	ATPase activity
NF554_RS13900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NF554_RS13925	COG1846	Transcriptional regulator
NF554_RS13930	COG1061	Type III restriction enzyme res subunit
NF554_RS13950	COG3973	AAA domain
NF554_RS13955	COG3142	Participates in the control of copper homeostasis
NF554_RS13970	COG1984	allophanate hydrolase subunit 2
NF554_RS13975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NF554_RS13980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NF554_RS14020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NF554_RS14055	COG2197	response regulator
NF554_RS14060	COG4251	negative regulation of phosphorylation
NF554_RS14110	COG1175	transmembrane transport
NF554_RS14115	COG0395	ABC-type sugar transport system, permease component
NF554_RS14145	COG1595	DNA-templated transcription, initiation
NF554_RS14210	COG0463	Glycosyl transferase, family 2
NF554_RS14220	COG1877	trehalose-phosphatase activity
NF554_RS14220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NF554_RS14240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NF554_RS14265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NF554_RS14290	COG0666	response to abiotic stimulus
NF554_RS14300	COG4585	Histidine kinase
NF554_RS14305	COG2197	response regulator
NF554_RS14345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS14385	COG0745	RESPONSE REGULATOR receiver
NF554_RS14410	COG2226	methyltransferase
NF554_RS14415	COG2188	Transcriptional regulator
NF554_RS14500	COG3842	ATPase activity
NF554_RS14510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NF554_RS14520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NF554_RS14525	COG0215	cysteine-tRNA ligase activity
NF554_RS14535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NF554_RS14540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NF554_RS14545	COG1329	Transcriptional regulator
NF554_RS14580	COG0588	phosphoglycerate mutase activity
NF554_RS14615	COG0438	transferase activity, transferring glycosyl groups
NF554_RS14655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS14665	COG2318	DinB family
NF554_RS14690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NF554_RS14695	COG0736	holo-[acyl-carrier-protein] synthase activity
NF554_RS14725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS14750	COG4770	biotin carboxylase activity
NF554_RS14780	COG0475	glutathione-regulated potassium exporter activity
NF554_RS14840	COG4552	Acetyltransferase involved in intracellular survival and related
NF554_RS14855	COG1490	D-aminoacyl-tRNA deacylase activity
NF554_RS14865	COG0735	belongs to the Fur family
NF554_RS14870	COG3485	protocatechuate 3,4-dioxygenase
NF554_RS14905	COG2897	thiosulfate sulfurtransferase activity
NF554_RS14930	COG0745	RESPONSE REGULATOR receiver
NF554_RS14935	COG1609	Transcriptional regulator
NF554_RS14940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NF554_RS14980	COG0154	amidase activity
NF554_RS14995	COG0737	Belongs to the 5'-nucleotidase family
NF554_RS15010	COG0456	acetyltransferase
NF554_RS15020	COG1725	Transcriptional regulator
NF554_RS15025	COG1116	anion transmembrane transporter activity
NF554_RS15045	COG0494	nUDIX hydrolase
NF554_RS15045	COG0406	alpha-ribazole phosphatase activity
NF554_RS15050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NF554_RS15070	COG0306	phosphate transporter
NF554_RS15080	COG1937	Protein conserved in bacteria
NF554_RS15095	COG0671	phosphoesterase, PA-phosphatase related
NF554_RS15170	COG1846	Transcriptional regulator
NF554_RS15185	COG1252	NADH dehydrogenase
NF554_RS15210	COG0579	oxidoreductase
NF554_RS15215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NF554_RS15225	COG0739	heme binding
NF554_RS15225	COG0741	lytic transglycosylase activity
NF554_RS15225	COG1196	nuclear chromosome segregation
NF554_RS15235	COG0789	Transcriptional regulator
NF554_RS15260	COG0513	Belongs to the DEAD box helicase family
NF554_RS15270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NF554_RS15275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NF554_RS15310	COG0785	Cytochrome C biogenesis protein
NF554_RS15315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NF554_RS15315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NF554_RS15325	COG1643	Atp-dependent helicase
NF554_RS15360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NF554_RS15375	COG2318	DinB family
NF554_RS15380	COG0739	heme binding
NF554_RS15380	COG0741	lytic transglycosylase activity
NF554_RS15380	COG1196	nuclear chromosome segregation
NF554_RS15390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NF554_RS15395	COG0047	phosphoribosylformylglycinamidine synthase activity
NF554_RS15400	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NF554_RS15440	COG2197	response regulator
NF554_RS15450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NF554_RS15465	COG0151	Belongs to the GarS family
NF554_RS15615	COG0492	ferredoxin-NADP+ reductase activity
NF554_RS15620	COG2815	serine threonine protein kinase
NF554_RS15620	COG0515	serine threonine protein kinase
NF554_RS15655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NF554_RS15680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NF554_RS15705	COG4941	Belongs to the sigma-70 factor family
NF554_RS15740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NF554_RS15915	COG1518	maintenance of DNA repeat elements
NF554_RS15940	COG1191	sigma factor activity
NF554_RS15945	COG1191	sigma factor activity
NF554_RS15960	COG1846	Transcriptional regulator
NF554_RS15970	COG2353	YceI-like domain
NF554_RS15975	COG3467	pyridoxamine 5'-phosphate
NF554_RS15990	COG0477	Major facilitator Superfamily
NF554_RS16005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NF554_RS16015	COG2205	protein histidine kinase activity
NF554_RS16020	COG0745	RESPONSE REGULATOR receiver
NF554_RS16140	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS16145	COG1595	DNA-templated transcription, initiation
NF554_RS16170	COG1960	acyl-CoA dehydrogenase activity
NF554_RS16195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NF554_RS16250	COG1999	signal sequence binding
NF554_RS16260	COG2372	response to copper ion
NF554_RS16265	COG2837	iron assimilation
NF554_RS16275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NF554_RS16280	COG0561	phosphatase activity
NF554_RS16305	COG1131	(ABC) transporter
NF554_RS16320	COG0789	Transcriptional regulator
NF554_RS16325	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NF554_RS16335	COG0561	phosphatase activity
NF554_RS16350	COG1294	oxidase, subunit
NF554_RS16355	COG1271	oxidase subunit
NF554_RS16360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NF554_RS16365	COG1609	Transcriptional regulator
NF554_RS16370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NF554_RS16380	COG3152	Membrane
NF554_RS16385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NF554_RS16410	COG0662	Cupin 2, conserved barrel domain protein
NF554_RS16415	COG1950	PFAM Membrane protein of
NF554_RS16420	COG0626	cystathionine gamma-synthase activity
NF554_RS16440	COG2814	Major facilitator Superfamily
NF554_RS16470	COG0305	Participates in initiation and elongation during chromosome replication
NF554_RS16480	COG0359	binds to the 23S rRNA
NF554_RS16485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NF554_RS16490	COG0629	single-stranded DNA binding
NF554_RS16495	COG0360	Binds together with S18 to 16S ribosomal RNA
NF554_RS16520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NF554_RS16540	COG0617	tRNA 3'-terminal CCA addition
NF554_RS16555	COG2815	serine threonine protein kinase
NF554_RS16555	COG0515	serine threonine protein kinase
NF554_RS16560	COG1595	DNA-templated transcription, initiation
NF554_RS16570	COG0492	ferredoxin-NADP+ reductase activity
NF554_RS16575	COG3118	belongs to the thioredoxin family
NF554_RS16590	COG1192	Involved in chromosome partitioning
NF554_RS16595	COG0357	Ribosomal RNA small subunit methyltransferase G
NF554_RS16605	COG0706	membrane insertase activity
NF554_RS16610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NF554_RS16615	COG0594	ribonuclease P activity
NF554_RS16630	COG0592	DNA-directed DNA polymerase activity
NF554_RS16635	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NF554_RS16640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NF554_RS16645	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
NF554_RS16655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NF554_RS16690	COG0515	serine threonine protein kinase
NF554_RS16730	COG0705	Rhomboid family
NF554_RS16745	COG3764	Sortase (surface protein transpeptidase)
NF554_RS16760	COG3764	Sortase (surface protein transpeptidase)
NF554_RS16765	COG3764	Sortase (surface protein transpeptidase)
NF554_RS16770	COG0515	serine threonine protein kinase
NF554_RS16775	COG0768	penicillin binding
NF554_RS16790	COG1716	ATPase activity
NF554_RS16795	COG1716	ATPase activity
NF554_RS16820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NF554_RS16825	COG1960	acyl-CoA dehydrogenase activity
NF554_RS16830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NF554_RS16835	COG2151	metal-sulfur cluster biosynthetic enzyme
NF554_RS16840	COG3396	Phenylacetate-CoA oxygenase
NF554_RS16845	COG3460	Phenylacetate-CoA oxygenase
NF554_RS16850	COG3396	Phenylacetate-CoA oxygenase
NF554_RS16875	COG1309	transcriptional regulator
NF554_RS16880	COG1522	sequence-specific DNA binding
NF554_RS16900	COG0746	molybdenum cofactor guanylyltransferase activity
NF554_RS16910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NF554_RS16915	COG0604	alcohol dehydrogenase
NF554_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS16915	COG3321	synthase
NF554_RS16930	COG4591	ABC-type transport system involved in lipoprotein release permease component
NF554_RS16930	COG1136	(ABC) transporter
NF554_RS16945	COG0515	serine threonine protein kinase
NF554_RS16950	COG0515	serine threonine protein kinase
NF554_RS16975	COG0022	dehydrogenase e1 component
NF554_RS16980	COG0508	dehydrogenase complex catalyzes the overall conversion of
NF554_RS17020	COG1802	Transcriptional regulator
NF554_RS17035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NF554_RS17055	COG3629	intracellular signal transduction
NF554_RS17055	COG3903	Transcriptional regulator
NF554_RS17065	COG1362	aminopeptidase activity
NF554_RS17070	COG1960	acyl-CoA dehydrogenase activity
NF554_RS17080	COG1741	Belongs to the pirin family
NF554_RS17095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NF554_RS17110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NF554_RS17115	COG0745	RESPONSE REGULATOR receiver
NF554_RS17120	COG2205	protein histidine kinase activity
NF554_RS17165	COG0431	NADPH-dependent FMN reductase
NF554_RS17200	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NF554_RS17210	COG0180	Tryptophanyl-tRNA synthetase
NF554_RS17245	COG0475	glutathione-regulated potassium exporter activity
NF554_RS17250	COG0490	domain, Protein
NF554_RS17280	COG2268	Band 7 protein
NF554_RS17305	COG0454	-acetyltransferase
NF554_RS17345	COG1278	Cold shock
NF554_RS17365	COG0475	glutathione-regulated potassium exporter activity
NF554_RS17400	COG3585	molybdate ion transport
NF554_RS17425	COG2124	cytochrome p450
NF554_RS17430	COG2124	cytochrome p450
NF554_RS17470	COG1609	Transcriptional regulator
NF554_RS17480	COG0667	Aldo Keto reductase
NF554_RS17490	COG1695	Transcriptional regulator
NF554_RS17505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS17530	COG0519	Catalyzes the synthesis of GMP from XMP
NF554_RS17530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NF554_RS17545	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NF554_RS17555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NF554_RS17565	COG0745	RESPONSE REGULATOR receiver
NF554_RS17620	COG1902	pentaerythritol trinitrate reductase activity
NF554_RS17635	COG0367	asparagine synthase
NF554_RS17640	COG2272	Belongs to the type-B carboxylesterase lipase family
NF554_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS17720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NF554_RS17740	COG2130	NADP-dependent
NF554_RS17750	COG1533	DNA photolyase activity
NF554_RS17760	COG1376	ErfK ybiS ycfS ynhG family protein
NF554_RS17775	COG0745	RESPONSE REGULATOR receiver
NF554_RS17780	COG2205	protein histidine kinase activity
NF554_RS17800	COG2197	response regulator
NF554_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS17820	COG1309	transcriptional regulator
NF554_RS17890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NF554_RS17920	COG0717	Belongs to the dCTP deaminase family
NF554_RS17945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NF554_RS17950	COG0443	Heat shock 70 kDa protein
NF554_RS17955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NF554_RS17960	COG0484	heat shock protein binding
NF554_RS17995	COG0542	response to heat
NF554_RS18020	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NF554_RS18035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NF554_RS18040	COG0191	fructose-bisphosphate aldolase activity
NF554_RS18045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NF554_RS18050	COG0477	Major facilitator Superfamily
NF554_RS18065	COG3844	kynureninase activity
NF554_RS18075	COG0702	epimerase
NF554_RS18085	COG2197	response regulator
NF554_RS18110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NF554_RS18115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NF554_RS18125	COG0590	tRNA wobble adenosine to inosine editing
NF554_RS18185	COG1960	acyl-CoA dehydrogenase activity
NF554_RS18190	COG0662	Cupin 2, conserved barrel domain protein
NF554_RS18200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS18225	COG0667	Aldo Keto reductase
NF554_RS18235	COG0592	DNA-directed DNA polymerase activity
NF554_RS18250	COG3226	Transcriptional regulator
NF554_RS18260	COG0738	Major facilitator superfamily
NF554_RS18265	COG0515	serine threonine protein kinase
NF554_RS18265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NF554_RS18275	COG0693	protein deglycase activity
NF554_RS18285	COG1802	Transcriptional regulator
NF554_RS18305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NF554_RS18310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NF554_RS18345	COG1595	DNA-templated transcription, initiation
NF554_RS18365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NF554_RS18375	COG2755	lipolytic protein G-D-S-L family
NF554_RS18410	COG0515	serine threonine protein kinase
NF554_RS18415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NF554_RS18420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NF554_RS18455	COG1401	restriction endodeoxyribonuclease activity
NF554_RS18475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NF554_RS18550	COG1408	metallophosphoesterase
NF554_RS18555	COG1610	YqeY-like protein
NF554_RS18560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NF554_RS18570	COG0003	Pfam Anion-transporting ATPase
NF554_RS18595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NF554_RS18625	COG2267	carboxylic ester hydrolase activity
NF554_RS18640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NF554_RS18645	COG0288	reversible hydration of carbon dioxide
NF554_RS18705	COG1111	helicase
NF554_RS18705	COG1205	dead DEAH box helicase
NF554_RS18710	COG1366	Belongs to the anti-sigma-factor antagonist family
NF554_RS18720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NF554_RS18730	COG2890	protein-(glutamine-N5) methyltransferase activity
NF554_RS18740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NF554_RS18740	COG1754	DNA topoisomerase type I activity
NF554_RS18745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NF554_RS18750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NF554_RS18765	COG1181	Belongs to the D-alanine--D-alanine ligase family
NF554_RS18780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS18785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NF554_RS18790	COG4948	Mandelate Racemase Muconate Lactonizing
NF554_RS18805	COG0372	Belongs to the citrate synthase family
NF554_RS18825	COG2205	protein histidine kinase activity
NF554_RS18835	COG0326	Molecular chaperone. Has ATPase activity
NF554_RS18855	COG1725	Transcriptional regulator
NF554_RS18865	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NF554_RS18895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NF554_RS18895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NF554_RS18930	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS18955	COG0655	NAD(P)H dehydrogenase (quinone) activity
NF554_RS18970	COG0586	Pfam SNARE associated Golgi protein
NF554_RS18980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NF554_RS18985	COG2027	D-alanyl-D-alanine carboxypeptidase
NF554_RS18995	COG0037	tRNA processing
NF554_RS19010	COG0302	gtp cyclohydrolase
NF554_RS19025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NF554_RS19040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NF554_RS19040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NF554_RS19050	COG0517	IMP dehydrogenase activity
NF554_RS19050	COG1125	glycine betaine transport
NF554_RS19055	COG1174	glycine betaine transport
NF554_RS19060	COG1174	glycine betaine transport
NF554_RS19075	COG0649	NAD binding
NF554_RS19090	COG2197	response regulator
NF554_RS19115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NF554_RS19120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NF554_RS19130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NF554_RS19150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NF554_RS19185	COG0739	heme binding
NF554_RS19190	COG2205	protein histidine kinase activity
NF554_RS19195	COG0745	RESPONSE REGULATOR receiver
NF554_RS19205	COG1595	DNA-templated transcription, initiation
NF554_RS19210	COG1194	a g-specific adenine glycosylase
NF554_RS19220	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NF554_RS19240	COG0248	Ppx GppA phosphatase
NF554_RS19245	COG1082	Xylose isomerase domain protein TIM barrel
NF554_RS19255	COG0129	dihydroxy-acid dehydratase activity
NF554_RS19265	COG4991	sh3 domain protein
NF554_RS19275	COG1129	ABC transporter
NF554_RS19275	COG0842	Transport permease protein
NF554_RS19285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NF554_RS19310	COG2223	nitrite transmembrane transporter activity
NF554_RS19365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NF554_RS19370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NF554_RS19375	COG0181	hydroxymethylbilane synthase activity
NF554_RS19380	COG1648	precorrin-2 dehydrogenase activity
NF554_RS19380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NF554_RS19385	COG0113	porphobilinogen synthase activity
NF554_RS19415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NF554_RS19450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NF554_RS19460	COG0018	arginyl-trna synthetase
NF554_RS19465	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NF554_RS19490	COG1690	Belongs to the RtcB family
NF554_RS19535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NF554_RS19545	COG2382	esterase
NF554_RS19560	COG0785	Cytochrome C biogenesis protein
NF554_RS19565	COG1333	cytochrome c biogenesis protein
NF554_RS19570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NF554_RS19580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NF554_RS19585	COG0109	protoheme IX farnesyltransferase activity
NF554_RS19595	COG0163	prenyltransferase activity
NF554_RS19610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NF554_RS19625	COG1301	dicarboxylic acid transport
NF554_RS19645	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS19690	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS19695	COG0183	Belongs to the thiolase family
NF554_RS19770	COG0076	glutamate decarboxylase activity
NF554_RS19795	COG0454	-acetyltransferase
NF554_RS19815	COG1309	transcriptional regulator
NF554_RS19820	COG0667	Aldo Keto reductase
NF554_RS19845	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NF554_RS19880	COG0768	penicillin binding
NF554_RS19890	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NF554_RS19920	COG3655	Transcriptional regulator
NF554_RS20020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NF554_RS20065	COG0463	Glycosyl transferase, family 2
NF554_RS20090	COG0475	glutathione-regulated potassium exporter activity
NF554_RS20095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NF554_RS20130	COG2197	response regulator
NF554_RS20140	COG1022	Amp-dependent synthetase and ligase
NF554_RS20160	COG1846	Transcriptional regulator
NF554_RS20205	COG0243	molybdopterin cofactor binding
NF554_RS20210	COG0437	4 iron, 4 sulfur cluster binding
NF554_RS20230	COG1970	mechanosensitive ion channel activity
NF554_RS20240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NF554_RS20265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NF554_RS20270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NF554_RS20280	COG0315	cyclic pyranopterin monophosphate synthase activity
NF554_RS20325	COG0708	Exodeoxyribonuclease III
NF554_RS20335	COG2072	flavoprotein involved in K transport
NF554_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS20370	COG0793	Belongs to the peptidase S41A family
NF554_RS20370	COG4946	Tricorn protease homolog
NF554_RS20380	COG2409	Drug exporters of the RND superfamily
NF554_RS20395	COG0310	cobalt ion transport
NF554_RS20405	COG1122	ATPase activity
NF554_RS20410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NF554_RS20440	COG1115	amino acid carrier protein
NF554_RS20480	COG0442	prolyl-tRNA aminoacylation
NF554_RS20560	COG0084	hydrolase, TatD family'
NF554_RS20570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NF554_RS20575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NF554_RS20580	COG2318	DinB family
NF554_RS20585	COG2813	Specifically methylates the guanine in position
NF554_RS20605	COG4115	mRNA cleavage
NF554_RS20610	COG2161	toxin-antitoxin pair type II binding
NF554_RS20615	COG0488	(ABC) transporter
NF554_RS20640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NF554_RS20665	COG2197	response regulator
NF554_RS20675	COG4106	trans-aconitate 2-methyltransferase activity
NF554_RS20695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NF554_RS20705	COG0193	aminoacyl-tRNA hydrolase activity
NF554_RS20710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NF554_RS20715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NF554_RS20720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NF554_RS20735	COG4585	Histidine kinase
NF554_RS20770	COG2124	cytochrome p450
NF554_RS20800	COG0477	Major facilitator Superfamily
NF554_RS20810	COG1136	(ABC) transporter
NF554_RS20815	COG0577	efflux transmembrane transporter activity
NF554_RS20825	COG3629	intracellular signal transduction
NF554_RS20825	COG3903	Transcriptional regulator
NF554_RS20990	COG2124	cytochrome p450
NF554_RS21010	COG0148	phosphopyruvate hydratase activity
NF554_RS21035	COG1252	NADH dehydrogenase
NF554_RS21040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NF554_RS21045	COG0577	efflux transmembrane transporter activity
NF554_RS21045	COG1136	(ABC) transporter
NF554_RS21050	COG0577	efflux transmembrane transporter activity
NF554_RS21050	COG1136	(ABC) transporter
NF554_RS21075	COG0183	Belongs to the thiolase family
NF554_RS21080	COG2755	lipolytic protein G-D-S-L family
NF554_RS21125	COG0531	amino acid
NF554_RS21130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NF554_RS21135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NF554_RS21145	COG1228	amidohydrolase
NF554_RS21150	COG1191	sigma factor activity
NF554_RS21155	COG1366	Belongs to the anti-sigma-factor antagonist family
NF554_RS21185	COG3104	oligopeptide transport
NF554_RS21190	COG0745	RESPONSE REGULATOR receiver
NF554_RS21195	COG2205	protein histidine kinase activity
NF554_RS21235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NF554_RS21270	COG1316	TRANSCRIPTIONal
NF554_RS21280	COG1316	TRANSCRIPTIONal
NF554_RS21290	COG1316	TRANSCRIPTIONal
NF554_RS21295	COG1316	TRANSCRIPTIONal
NF554_RS21310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NF554_RS21320	COG0778	Nitroreductase
NF554_RS21320	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NF554_RS21325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NF554_RS21360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NF554_RS21365	COG2835	tetraacyldisaccharide 4'-kinase activity
NF554_RS21375	COG1482	cell wall glycoprotein biosynthetic process
NF554_RS21385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NF554_RS21445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NF554_RS21450	COG0745	RESPONSE REGULATOR receiver
NF554_RS21455	COG5000	phosphorelay sensor kinase activity
NF554_RS21455	COG5002	protein histidine kinase activity
NF554_RS21460	COG0823	Involved in the tonB-independent uptake of proteins
NF554_RS21465	COG1040	competence protein
NF554_RS21470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NF554_RS21475	COG2197	response regulator
NF554_RS21490	COG0653	protein targeting
NF554_RS21515	COG2902	Dehydrogenase
NF554_RS21530	COG1309	transcriptional regulator
NF554_RS21540	COG0395	ABC-type sugar transport system, permease component
NF554_RS21545	COG1175	transmembrane transport
NF554_RS21550	COG1653	transport
NF554_RS21560	COG0515	serine threonine protein kinase
NF554_RS21565	COG0515	serine threonine protein kinase
NF554_RS21570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NF554_RS21585	COG2884	Cell division ATP-binding protein ftsE
NF554_RS21590	COG2177	Part of the ABC transporter FtsEX involved in
NF554_RS21595	COG0793	Belongs to the peptidase S41A family
NF554_RS21600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NF554_RS21645	COG0583	DNA-binding transcription factor activity
NF554_RS21650	COG2223	nitrite transmembrane transporter activity
NF554_RS21680	COG3973	AAA domain
NF554_RS21680	COG3973	AAA domain
NF554_RS21690	COG0776	regulation of translation
NF554_RS21695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NF554_RS21700	COG1678	Uncharacterized ACR, COG1678
NF554_RS21715	COG1175	transmembrane transport
NF554_RS21720	COG0395	ABC-type sugar transport system, permease component
NF554_RS21725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NF554_RS21765	COG3654	unkown
NF554_RS21770	COG1061	Type III restriction enzyme res subunit
NF554_RS21780	COG3480	Lon protease (S16) C-terminal proteolytic domain
NF554_RS21785	COG1732	Glycine betaine
NF554_RS21790	COG1174	glycine betaine transport
NF554_RS21800	COG1174	glycine betaine transport
NF554_RS21810	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NF554_RS21820	COG0277	FAD linked oxidase domain protein
NF554_RS21865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NF554_RS21890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS21915	COG1234	tRNA 3'-trailer cleavage
NF554_RS21920	COG1263	PTS System
NF554_RS21925	COG1263	PTS System
NF554_RS21930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NF554_RS21935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NF554_RS21945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NF554_RS21955	COG0477	Major facilitator Superfamily
NF554_RS21980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NF554_RS21995	COG4555	ABC transporter
NF554_RS22010	COG2733	membrane
NF554_RS22020	COG2313	pseudouridylate synthase activity
NF554_RS22030	COG0546	phosphoglycolate phosphatase activity
NF554_RS22035	COG0697	spore germination
NF554_RS22040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NF554_RS22075	COG0789	Transcriptional regulator
NF554_RS22085	COG3409	Peptidoglycan-binding domain 1 protein
NF554_RS22105	COG0745	RESPONSE REGULATOR receiver
NF554_RS22115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NF554_RS22120	COG1215	transferase activity, transferring glycosyl groups
NF554_RS22165	COG3764	Sortase (surface protein transpeptidase)
NF554_RS22175	COG0706	membrane insertase activity
NF554_RS22175	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
NF554_RS22185	COG4702	Belongs to the UPF0303 family
NF554_RS22220	COG2188	Transcriptional regulator
NF554_RS22225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS22295	COG3397	chitin binding
NF554_RS22315	COG1126	abc transporter atp-binding protein
NF554_RS22320	COG0765	amino acid transport
NF554_RS22325	COG0765	amino acid transport
NF554_RS22330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS22345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS22410	COG0588	phosphoglycerate mutase activity
NF554_RS22455	COG2985	domain, Protein
NF554_RS22470	COG0395	ABC-type sugar transport system, permease component
NF554_RS22500	COG4977	sequence-specific DNA binding
NF554_RS22505	COG0589	response to stress
NF554_RS22510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NF554_RS22535	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NF554_RS22540	COG0076	glutamate decarboxylase activity
NF554_RS22560	COG1960	acyl-CoA dehydrogenase activity
NF554_RS22575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NF554_RS22580	COG1309	transcriptional regulator
NF554_RS22595	COG0515	serine threonine protein kinase
NF554_RS22595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NF554_RS22600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NF554_RS22600	COG2755	lipolytic protein G-D-S-L family
NF554_RS22620	COG1946	Acyl-CoA thioesterase
NF554_RS22645	COG1396	sequence-specific DNA binding
NF554_RS22665	COG3960	tartronate-semialdehyde synthase activity
NF554_RS22705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS22710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS22715	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS22760	COG1404	Belongs to the peptidase S8 family
NF554_RS22820	COG1609	Transcriptional regulator
NF554_RS22920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NF554_RS22955	COG0500	methyltransferase
NF554_RS22955	COG3615	Tellurite resistance protein tehB
NF554_RS22965	COG2318	DinB family
NF554_RS22985	COG3718	enzyme involved in inositol metabolism
NF554_RS22990	COG3962	Belongs to the TPP enzyme family
NF554_RS23005	COG1131	(ABC) transporter
NF554_RS23030	COG4585	Histidine kinase
NF554_RS23050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NF554_RS23095	COG2346	COG2346, Truncated hemoglobins
NF554_RS23100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NF554_RS23145	COG1486	melibiose metabolic process
NF554_RS23150	COG0395	ABC-type sugar transport system, permease component
NF554_RS23155	COG1175	transmembrane transport
NF554_RS23165	COG1940	carbohydrate kinase activity
NF554_RS23170	COG0668	transmembrane transport
NF554_RS23180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NF554_RS23205	COG4266	Belongs to the allantoicase family
NF554_RS23240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NF554_RS23255	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS23270	COG3655	Transcriptional regulator
NF554_RS23280	COG0110	maltose O-acetyltransferase activity
NF554_RS23295	COG0640	Transcriptional regulator
NF554_RS23300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NF554_RS23310	COG0783	Belongs to the Dps family
NF554_RS23320	COG1113	amino acid transport
NF554_RS23325	COG1113	amino acid transport
NF554_RS23335	COG1113	amino acid transport
NF554_RS23350	COG4552	Acetyltransferase involved in intracellular survival and related
NF554_RS23360	COG0475	glutathione-regulated potassium exporter activity
NF554_RS23365	COG3594	Acyltransferase
NF554_RS23385	COG0544	peptidyl-prolyl cis-trans isomerase activity
NF554_RS23390	COG0740	serine-type endopeptidase activity
NF554_RS23395	COG0740	serine-type endopeptidase activity
NF554_RS23400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NF554_RS23410	COG0525	valine-tRNA ligase activity
NF554_RS23415	COG0285	dihydrofolate synthase activity
NF554_RS23425	COG0105	UTP biosynthetic process
NF554_RS23430	COG1077	Cell shape determining protein MreB Mrl
NF554_RS23445	COG0768	penicillin binding
NF554_RS23450	COG0772	Belongs to the SEDS family
NF554_RS23475	COG1530	ribonuclease E activity
NF554_RS23525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NF554_RS23530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NF554_RS23535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NF554_RS23560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NF554_RS23570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NF554_RS23585	COG0501	Belongs to the peptidase M48B family
NF554_RS23600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NF554_RS23610	COG0799	negative regulation of ribosome biogenesis
NF554_RS23615	COG0588	phosphoglycerate mutase activity
NF554_RS23640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NF554_RS23650	COG0495	leucyl-tRNA aminoacylation
NF554_RS23665	COG1555	photosystem II stabilization
NF554_RS23690	COG0268	Binds directly to 16S ribosomal RNA
NF554_RS23695	COG0481	GTPase activity
NF554_RS23700	COG1022	Amp-dependent synthetase and ligase
NF554_RS23730	COG1420	regulation of RNA biosynthetic process
NF554_RS23735	COG0484	heat shock protein binding
NF554_RS23750	COG0537	adenosine 5'-monophosphoramidase activity
NF554_RS23755	COG1234	tRNA 3'-trailer cleavage
NF554_RS23760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NF554_RS23770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NF554_RS23780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NF554_RS23790	COG2315	Protein conserved in bacteria
NF554_RS23800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NF554_RS23815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NF554_RS23825	COG1381	Involved in DNA repair and RecF pathway recombination
NF554_RS23830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NF554_RS23840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NF554_RS23845	COG1121	(ABC) transporter
NF554_RS23850	COG0803	Belongs to the bacterial solute-binding protein 9 family
NF554_RS23850	COG3443	Belongs to the bacterial solute-binding protein 9 family
NF554_RS23855	COG0423	glycine-tRNA ligase activity
NF554_RS23875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NF554_RS23885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NF554_RS23915	COG2197	response regulator
NF554_RS23930	COG4221	oxidoreductase activity
NF554_RS23985	COG2066	Belongs to the glutaminase family
NF554_RS24010	COG4942	peptidase
NF554_RS24065	COG2188	Transcriptional regulator
NF554_RS24085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NF554_RS24095	COG0574	Belongs to the PEP-utilizing enzyme family
NF554_RS24095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NF554_RS24120	COG2146	nitrite reductase [NAD(P)H] activity
NF554_RS24120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NF554_RS24175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NF554_RS24185	COG0477	Major facilitator Superfamily
NF554_RS24195	COG2226	methyltransferase
NF554_RS24200	COG0358	DNA primase activity
NF554_RS24205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NF554_RS24245	COG1216	Glycosyl transferase, family 2
NF554_RS24250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NF554_RS24265	COG0438	transferase activity, transferring glycosyl groups
NF554_RS24270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NF554_RS24280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NF554_RS24280	COG0825	malonyl-CoA metabolic process
NF554_RS24285	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS24295	COG1522	sequence-specific DNA binding
NF554_RS24325	COG2130	NADP-dependent
NF554_RS24330	COG1764	response to oxidative stress
NF554_RS24340	COG1309	transcriptional regulator
NF554_RS24365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS24370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS24375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS24390	COG1741	Belongs to the pirin family
NF554_RS24415	COG0789	Transcriptional regulator
NF554_RS24420	COG0667	Aldo Keto reductase
NF554_RS24435	COG2197	response regulator
NF554_RS24455	COG1309	transcriptional regulator
NF554_RS24470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NF554_RS24560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NF554_RS24595	COG2259	Doxx family
NF554_RS24645	COG2124	cytochrome p450
NF554_RS24650	COG0183	Belongs to the thiolase family
NF554_RS24660	COG3845	ABC transporter
NF554_RS24725	COG1309	transcriptional regulator
NF554_RS24730	COG0438	transferase activity, transferring glycosyl groups
NF554_RS24760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS24800	COG0655	NAD(P)H dehydrogenase (quinone) activity
NF554_RS24820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NF554_RS24825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NF554_RS24845	COG3629	intracellular signal transduction
NF554_RS24845	COG3903	Transcriptional regulator
NF554_RS24855	COG1960	acyl-CoA dehydrogenase activity
NF554_RS24860	COG0183	Belongs to the thiolase family
NF554_RS24870	COG2030	dehydratase
NF554_RS24895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NF554_RS24900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NF554_RS24920	COG0800	Aldolase
NF554_RS24925	COG3022	response to hydroperoxide
NF554_RS24955	COG2273	Hydrolase Family 16
NF554_RS24980	COG0384	phenazine biosynthesis protein PhzF
NF554_RS24995	COG3540	Alkaline phosphatase
NF554_RS25005	COG2814	Major facilitator Superfamily
NF554_RS25020	COG1834	amidinotransferase
NF554_RS25040	COG1120	ATPase activity
NF554_RS25045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS25050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NF554_RS25110	COG1994	Peptidase M50
NF554_RS25130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NF554_RS25135	COG0477	Major facilitator Superfamily
NF554_RS25150	COG2814	Major facilitator Superfamily
NF554_RS25155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NF554_RS25155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NF554_RS25160	COG2132	Multicopper oxidase
NF554_RS25175	COG0174	glutamine synthetase
NF554_RS25245	COG0454	-acetyltransferase
NF554_RS25245	COG0456	acetyltransferase
NF554_RS25250	COG2890	protein-(glutamine-N5) methyltransferase activity
NF554_RS25255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NF554_RS25280	COG1609	Transcriptional regulator
NF554_RS25290	COG1175	transmembrane transport
NF554_RS25295	COG3833	ABC-type maltose transport systems, permease component
NF554_RS25300	COG0366	Alpha amylase catalytic
NF554_RS25360	COG2197	response regulator
NF554_RS25370	COG0745	RESPONSE REGULATOR receiver
NF554_RS25405	COG1846	Transcriptional regulator
NF554_RS25465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NF554_RS25470	COG0321	lipoyl(octanoyl) transferase activity
NF554_RS25485	COG1090	epimerase
NF554_RS25505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NF554_RS25515	COG0508	dehydrogenase complex catalyzes the overall conversion of
NF554_RS25520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NF554_RS25525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NF554_RS25530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NF554_RS25550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NF554_RS25570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NF554_RS25590	COG4585	Histidine kinase
NF554_RS25595	COG2197	response regulator
NF554_RS25600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NF554_RS25610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NF554_RS25630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NF554_RS25635	COG1104	cysteine desulfurase activity
NF554_RS25640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NF554_RS25655	COG1376	ErfK ybiS ycfS ynhG family protein
NF554_RS25665	COG1845	cytochrome c oxidase, subunit III
NF554_RS25670	COG2010	Cytochrome c
NF554_RS25675	COG0723	plastoquinol--plastocyanin reductase activity
NF554_RS25680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NF554_RS25685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NF554_RS25690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NF554_RS25755	COG0003	Pfam Anion-transporting ATPase
NF554_RS25765	COG1940	carbohydrate kinase activity
NF554_RS25790	COG4585	Histidine kinase
NF554_RS25795	COG2197	response regulator
NF554_RS25800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NF554_RS25810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NF554_RS25820	COG2193	ferroxidase activity
NF554_RS25825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NF554_RS25830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NF554_RS25835	COG0515	serine threonine protein kinase
NF554_RS25835	COG2815	serine threonine protein kinase
NF554_RS25840	COG2022	thiamine diphosphate biosynthetic process
NF554_RS25850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS25850	COG2022	thiamine diphosphate biosynthetic process
NF554_RS25870	COG0352	thiamine-phosphate diphosphorylase activity
NF554_RS25900	COG1511	domain protein
NF554_RS25905	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NF554_RS25915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NF554_RS25935	COG0714	Associated with various cellular activities
NF554_RS25945	COG0275	rRNA processing
NF554_RS25955	COG0768	penicillin binding
NF554_RS25960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NF554_RS25970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NF554_RS25975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NF554_RS25985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NF554_RS26005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NF554_RS26010	COG1799	cell septum assembly
NF554_RS26020	COG3599	regulation of cell shape
NF554_RS26025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NF554_RS26035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NF554_RS26085	COG0587	DNA-directed DNA polymerase activity
NF554_RS26095	COG1432	Conserved Protein
NF554_RS26125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NF554_RS26140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NF554_RS26145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NF554_RS26150	COG0131	Imidazoleglycerol-phosphate dehydratase
NF554_RS26160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NF554_RS26165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NF554_RS26170	COG0251	oxidation-reduction process
NF554_RS26175	COG0107	imidazoleglycerol-phosphate synthase activity
NF554_RS26190	COG2508	Transcriptional regulator
NF554_RS26200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NF554_RS26205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NF554_RS26225	COG0134	indole-3-glycerol-phosphate synthase activity
NF554_RS26235	COG0133	tryptophan synthase activity
NF554_RS26240	COG0159	tryptophan synthase activity
NF554_RS26250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NF554_RS26260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NF554_RS26265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NF554_RS26295	COG0067	glutamate synthase
NF554_RS26295	COG0069	glutamate synthase activity
NF554_RS26295	COG0070	glutamate synthase
NF554_RS26305	COG0705	Rhomboid family
NF554_RS26325	COG1960	acyl-CoA dehydrogenase activity
NF554_RS26330	COG1960	acyl-CoA dehydrogenase activity
NF554_RS26335	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS26340	COG1309	transcriptional regulator
NF554_RS26350	COG1278	Cold shock
NF554_RS26375	COG1024	Enoyl-CoA hydratase
NF554_RS26380	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS26425	COG0287	Prephenate dehydrogenase
NF554_RS26425	COG1605	Chorismate mutase
NF554_RS26430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NF554_RS26445	COG2824	Alkylphosphonate utilization operon protein PhnA
NF554_RS26475	COG0737	Belongs to the 5'-nucleotidase family
NF554_RS26530	COG2050	protein possibly involved in aromatic compounds catabolism
NF554_RS26565	COG1643	Atp-dependent helicase
NF554_RS26570	COG2226	methyltransferase
NF554_RS26590	COG0237	dephospho-CoA kinase activity
NF554_RS26635	COG0436	Aminotransferase
NF554_RS26650	COG2860	membrane
NF554_RS26655	COG1473	amidohydrolase
NF554_RS26665	COG2313	pseudouridylate synthase activity
NF554_RS26675	COG2814	Major facilitator Superfamily
NF554_RS26680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NF554_RS26695	COG0556	nucleotide-excision repair
NF554_RS26725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NF554_RS26750	COG0322	excinuclease ABC activity
NF554_RS26755	COG1660	Displays ATPase and GTPase activities
NF554_RS26760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NF554_RS26765	COG1481	regulation of sporulation
NF554_RS26770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NF554_RS26775	COG0126	phosphoglycerate kinase activity
NF554_RS26780	COG0149	triose-phosphate isomerase activity
NF554_RS26785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NF554_RS26795	COG0166	Belongs to the GPI family
NF554_RS26810	COG4195	phage-related replication protein
NF554_RS26820	COG0363	glucosamine-6-phosphate deaminase activity
NF554_RS26835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NF554_RS26845	COG0109	protoheme IX farnesyltransferase activity
NF554_RS26855	COG1612	heme a metabolic process
NF554_RS26865	COG1131	(ABC) transporter
NF554_RS26880	COG0719	Fe-S assembly protein
NF554_RS26890	COG0396	ATPase activity
NF554_RS26895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NF554_RS26900	COG0822	iron-sulfur transferase activity
NF554_RS26925	COG3226	Transcriptional regulator
NF554_RS26940	COG2171	N-acyltransferase activity
NF554_RS26945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NF554_RS26975	COG0583	DNA-binding transcription factor activity
NF554_RS26990	COG0431	NADPH-dependent FMN reductase
NF554_RS27000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS27005	COG0768	penicillin binding
NF554_RS27040	COG1902	pentaerythritol trinitrate reductase activity
NF554_RS27070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NF554_RS27095	COG1797	cobyrinic acid a,c-diamide synthase activity
NF554_RS27110	COG1492	cobalamin metabolic process
NF554_RS27115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NF554_RS27130	COG0235	Class ii aldolase
NF554_RS27155	COG0488	(ABC) transporter
NF554_RS27165	COG1024	Enoyl-CoA hydratase
NF554_RS27205	COG3387	PFAM Glycoside hydrolase 15-related
NF554_RS27220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NF554_RS27255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NF554_RS27270	COG2261	transglycosylase associated protein
NF554_RS27275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NF554_RS27290	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS27295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NF554_RS27305	COG2186	Transcriptional regulator
NF554_RS27330	COG0560	Phosphoserine phosphatase
NF554_RS27330	COG3830	Belongs to the UPF0237 family
NF554_RS27335	COG1716	ATPase activity
NF554_RS27335	COG1131	(ABC) transporter
NF554_RS27335	COG0842	Transport permease protein
NF554_RS27345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NF554_RS27355	COG4585	Histidine kinase
NF554_RS27360	COG2197	response regulator
NF554_RS27370	COG1119	ATPase activity
NF554_RS27395	COG1881	PFAM PEBP family protein
NF554_RS27405	COG2094	Belongs to the DNA glycosylase MPG family
NF554_RS27445	COG0647	UMP catabolic process
NF554_RS27470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NF554_RS27475	COG0497	DNA recombination
NF554_RS27500	COG4166	transmembrane transport
NF554_RS27505	COG0601	transmembrane transport
NF554_RS27510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NF554_RS27520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NF554_RS27525	COG3119	arylsulfatase activity
NF554_RS27545	COG3387	PFAM Glycoside hydrolase 15-related
NF554_RS27550	COG0504	CTP synthase activity
NF554_RS27555	COG0494	nUDIX hydrolase
NF554_RS27565	COG0686	Belongs to the AlaDH PNT family
NF554_RS27580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NF554_RS27585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NF554_RS27590	COG1187	pseudouridine synthase activity
NF554_RS27605	COG0494	nUDIX hydrolase
NF554_RS27615	COG3541	Predicted nucleotidyltransferase
NF554_RS27620	COG3541	Predicted nucleotidyltransferase
NF554_RS27640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NF554_RS27650	COG1160	GTP binding
NF554_RS27685	COG0671	phosphoesterase, PA-phosphatase related
NF554_RS27690	COG0477	Major facilitator Superfamily
NF554_RS27695	COG1960	acyl-CoA dehydrogenase activity
NF554_RS27700	COG1799	cell septum assembly
NF554_RS27710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS27715	COG0765	amino acid transport
NF554_RS27735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NF554_RS27745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS27805	COG0587	DNA-directed DNA polymerase activity
NF554_RS27810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NF554_RS27830	COG4565	transcriptional regulatory protein
NF554_RS27850	COG0346	lactoylglutathione lyase activity
NF554_RS27865	COG1725	Transcriptional regulator
NF554_RS27880	COG2755	lipolytic protein G-D-S-L family
NF554_RS27900	COG2188	Transcriptional regulator
NF554_RS27905	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NF554_RS27915	COG0243	molybdopterin cofactor binding
NF554_RS27920	COG2851	Citrate transporter
NF554_RS27940	COG2326	polyphosphate kinase activity
NF554_RS27955	COG1960	acyl-CoA dehydrogenase activity
NF554_RS27975	COG0789	Transcriptional regulator
NF554_RS28000	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS28005	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS28015	COG2234	aminopeptidase activity
NF554_RS28015	COG4935	Belongs to the peptidase S8 family
NF554_RS28020	COG1960	acyl-CoA dehydrogenase activity
NF554_RS28040	COG2149	membrane
NF554_RS28045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NF554_RS28050	COG3573	Dehydrogenase
NF554_RS28080	COG3265	gluconokinase activity
NF554_RS28085	COG2186	Transcriptional regulator
NF554_RS28100	COG0564	pseudouridine synthase activity
NF554_RS28110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NF554_RS28140	COG0667	Aldo Keto reductase
NF554_RS28145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS28155	COG0598	Magnesium transport protein CorA
NF554_RS28175	COG0215	cysteine-tRNA ligase activity
NF554_RS28185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NF554_RS28190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NF554_RS28195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NF554_RS28200	COG1414	Transcriptional regulator
NF554_RS28205	COG1410	methionine synthase
NF554_RS28205	COG0646	methionine synthase
NF554_RS28215	COG4166	transmembrane transport
NF554_RS28220	COG2197	response regulator
NF554_RS28230	COG0517	IMP dehydrogenase activity
NF554_RS28230	COG1994	Peptidase M50
NF554_RS28250	COG1222	aaa ATPase
NF554_RS28255	COG4122	O-methyltransferase activity
NF554_RS28270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NF554_RS28275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NF554_RS28280	COG1609	Transcriptional regulator
NF554_RS28290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NF554_RS28295	COG0545	Peptidyl-prolyl cis-trans isomerase
NF554_RS28305	COG2378	regulation of single-species biofilm formation
NF554_RS28325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NF554_RS28330	COG0805	protein transport
NF554_RS28370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NF554_RS28375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NF554_RS28395	COG1595	DNA-templated transcription, initiation
NF554_RS28420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NF554_RS28425	COG0517	IMP dehydrogenase activity
NF554_RS28425	COG4175	Glycine betaine
NF554_RS28430	COG4176	ABC-type proline glycine betaine transport system permease component
NF554_RS28485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NF554_RS28490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NF554_RS28495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NF554_RS28500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NF554_RS28505	COG5002	protein histidine kinase activity
NF554_RS28510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NF554_RS28515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NF554_RS28515	COG0072	phenylalanine-tRNA ligase activity
NF554_RS28535	COG1649	PFAM Uncharacterised BCR, COG1649
NF554_RS28545	COG0697	spore germination
NF554_RS28560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NF554_RS28610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NF554_RS28615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NF554_RS28620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NF554_RS28625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NF554_RS28630	COG1438	arginine binding
NF554_RS28640	COG0137	argininosuccinate synthase activity
NF554_RS28645	COG0165	Argininosuccinate lyase
NF554_RS28660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NF554_RS28670	COG0477	Major facilitator Superfamily
NF554_RS28680	COG0584	glycerophosphoryl diester phosphodiesterase
NF554_RS28710	COG2011	ABC-type metal ion transport system permease component
NF554_RS28715	COG1464	Belongs to the NlpA lipoprotein family
NF554_RS28730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NF554_RS28735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NF554_RS28735	COG1648	precorrin-2 dehydrogenase activity
NF554_RS28790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NF554_RS28850	COG2176	DNA-directed DNA polymerase activity
NF554_RS28850	COG5002	protein histidine kinase activity
NF554_RS28865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NF554_RS28895	COG1560	Kdo2-lipid A biosynthetic process
NF554_RS28900	COG0438	transferase activity, transferring glycosyl groups
NF554_RS28910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NF554_RS28915	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NF554_RS28920	COG0217	transcriptional regulatory protein
NF554_RS28925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NF554_RS28930	COG0632	four-way junction helicase activity
NF554_RS28935	COG2255	four-way junction helicase activity
NF554_RS28945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NF554_RS28950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NF554_RS28955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NF554_RS28960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NF554_RS28965	COG1196	nuclear chromosome segregation
NF554_RS28980	COG0124	histidyl-tRNA synthetase
NF554_RS29000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NF554_RS29020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NF554_RS29025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NF554_RS29035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NF554_RS29040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NF554_RS29045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NF554_RS29050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NF554_RS29065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NF554_RS29070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NF554_RS29080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NF554_RS29085	COG0540	Belongs to the ATCase OTCase family
NF554_RS29090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NF554_RS29100	COG0505	Belongs to the CarA family
NF554_RS29115	COG0284	orotidine-5'-phosphate decarboxylase activity
NF554_RS29130	COG1758	RNA polymerase activity
NF554_RS29140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NF554_RS29155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NF554_RS29165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NF554_RS29170	COG2390	Transcriptional regulator
NF554_RS29185	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS29195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NF554_RS29210	COG2233	PERMEase
NF554_RS29215	COG0738	Major facilitator superfamily
NF554_RS29240	COG3201	nicotinamide mononucleotide transporter
NF554_RS29245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NF554_RS29245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NF554_RS29250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NF554_RS29255	COG0140	phosphoribosyl-ATP diphosphatase activity
NF554_RS29260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NF554_RS29300	COG1960	acyl-CoA dehydrogenase activity
NF554_RS29320	COG1216	Glycosyl transferase, family 2
NF554_RS29325	COG3030	protein affecting phage T7 exclusion by the F plasmid
NF554_RS29335	COG2270	Major facilitator Superfamily
NF554_RS29345	COG2364	Membrane
NF554_RS29410	COG2018	Roadblock/LC7 domain
NF554_RS29455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NF554_RS29465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NF554_RS29515	COG1716	ATPase activity
NF554_RS29535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NF554_RS29545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NF554_RS29545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NF554_RS29630	COG0697	spore germination
NF554_RS29660	COG0583	DNA-binding transcription factor activity
NF554_RS29685	COG2188	Transcriptional regulator
NF554_RS29730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NF554_RS29750	COG2318	DinB family
NF554_RS29800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NF554_RS29805	COG2226	methyltransferase
NF554_RS29830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NF554_RS29870	COG1832	CoA-binding protein
NF554_RS29875	COG1739	Uncharacterized protein family UPF0029
NF554_RS29880	COG0420	3'-5' exonuclease activity
NF554_RS29885	COG0419	ATPase involved in DNA repair
NF554_RS29890	COG1522	sequence-specific DNA binding
NF554_RS29910	COG0626	cystathionine gamma-synthase activity
NF554_RS29940	COG1595	DNA-templated transcription, initiation
NF554_RS29950	COG1940	carbohydrate kinase activity
NF554_RS29960	COG3663	DNA glycosylase
NF554_RS29965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NF554_RS29990	COG2226	methyltransferase
NF554_RS29995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NF554_RS30000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NF554_RS30005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NF554_RS30010	COG0156	8-amino-7-oxononanoate synthase activity
NF554_RS30055	COG0831	urea catabolic process
NF554_RS30060	COG0832	Belongs to the urease beta subunit family
NF554_RS30065	COG0804	urea catabolic process
NF554_RS30080	COG0829	nickel cation binding
NF554_RS30095	COG0204	Acyl-transferase
NF554_RS30110	COG0205	6-phosphofructokinase activity
NF554_RS30115	COG3442	glutamine amidotransferase
NF554_RS30125	COG0242	peptide deformylase activity
NF554_RS30135	COG1960	acyl-CoA dehydrogenase activity
NF554_RS30140	COG0386	Belongs to the glutathione peroxidase family
NF554_RS30155	COG1946	Acyl-CoA thioesterase
NF554_RS30170	COG1793	dna ligase
NF554_RS30175	COG1252	NADH dehydrogenase
NF554_RS30190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NF554_RS30190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NF554_RS30215	COG1132	(ABC) transporter
NF554_RS30230	COG0277	FAD linked oxidase domain protein
NF554_RS30240	COG1132	(ABC) transporter
NF554_RS30260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NF554_RS30270	COG1116	anion transmembrane transporter activity
NF554_RS30295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NF554_RS30315	COG0583	DNA-binding transcription factor activity
NF554_RS30340	COG0385	Bile acid
NF554_RS30370	COG4592	Periplasmic binding protein
NF554_RS30380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS30385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS30400	COG0542	response to heat
NF554_RS30410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NF554_RS30465	COG1335	isochorismatase
NF554_RS30480	COG2124	cytochrome p450
NF554_RS30485	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS30555	COG1982	Orn Lys Arg decarboxylase major
NF554_RS30560	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS30565	COG1357	PFAM Pentapeptide repeats (8 copies)
NF554_RS30590	COG0243	molybdopterin cofactor binding
NF554_RS30605	COG0745	RESPONSE REGULATOR receiver
NF554_RS30615	COG2835	tetraacyldisaccharide 4'-kinase activity
NF554_RS30635	COG4981	capsule polysaccharide biosynthetic process
NF554_RS30665	COG1472	Belongs to the glycosyl hydrolase 3 family
NF554_RS30675	COG1175	transmembrane transport
NF554_RS30680	COG1653	transport
NF554_RS30685	COG1609	Transcriptional regulator
NF554_RS30695	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS30700	COG0174	glutamine synthetase
NF554_RS30705	COG2186	Transcriptional regulator
NF554_RS30710	COG0531	amino acid
NF554_RS30755	COG1253	flavin adenine dinucleotide binding
NF554_RS30790	COG0515	serine threonine protein kinase
NF554_RS30790	COG2815	serine threonine protein kinase
NF554_RS30795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NF554_RS30815	COG2706	6-phosphogluconolactonase activity
NF554_RS30830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NF554_RS30880	COG0671	phosphoesterase, PA-phosphatase related
NF554_RS30895	COG0456	acetyltransferase
NF554_RS30900	COG0584	glycerophosphoryl diester phosphodiesterase
NF554_RS30950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NF554_RS30975	COG1940	carbohydrate kinase activity
NF554_RS30980	COG1660	Displays ATPase and GTPase activities
NF554_RS30995	COG0445	tRNA wobble uridine modification
NF554_RS31035	COG2223	nitrite transmembrane transporter activity
NF554_RS31095	COG1349	DNA-binding transcription factor activity
NF554_RS31105	COG0464	growth
NF554_RS31125	COG2045	Belongs to the ComB family
NF554_RS31180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NF554_RS31230	COG2264	protein methyltransferase activity
NF554_RS31285	COG3250	beta-galactosidase activity
NF554_RS31290	COG1879	ABC-type sugar transport system periplasmic component
NF554_RS31295	COG1129	ABC transporter
NF554_RS31305	COG1172	Belongs to the binding-protein-dependent transport system permease family
NF554_RS31310	COG1609	Transcriptional regulator
NF554_RS31325	COG1874	Beta-galactosidase
NF554_RS31325	COG0366	Alpha amylase catalytic
NF554_RS31340	COG2207	Transcriptional regulator
NF554_RS31345	COG0617	tRNA 3'-terminal CCA addition
NF554_RS31365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS31370	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS31375	COG1120	ATPase activity
NF554_RS31380	COG2837	iron assimilation
NF554_RS31410	COG1295	ribonuclease BN
NF554_RS31410	COG1959	2 iron, 2 sulfur cluster binding
NF554_RS31460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS31490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS31495	COG1120	ATPase activity
NF554_RS31515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NF554_RS31525	COG1191	sigma factor activity
NF554_RS31570	COG1461	Dihydroxyacetone kinase
NF554_RS31575	COG2376	Dihydroxyacetone kinase
NF554_RS31610	COG1982	Orn Lys Arg decarboxylase major
NF554_RS31625	COG0531	amino acid
NF554_RS31645	COG0297	glycogen (starch) synthase activity
NF554_RS31680	COG1191	sigma factor activity
NF554_RS31705	COG0640	Transcriptional regulator
NF554_RS31730	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NF554_RS31750	COG1116	anion transmembrane transporter activity
NF554_RS31760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NF554_RS31770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NF554_RS31775	COG0583	DNA-binding transcription factor activity
NF554_RS31790	COG2226	methyltransferase
NF554_RS31800	COG0798	PFAM Bile acid sodium symporter
NF554_RS31805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NF554_RS31810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NF554_RS31815	COG0573	inorganic phosphate transmembrane transporter activity
NF554_RS31820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NF554_RS31845	COG0243	molybdopterin cofactor binding
NF554_RS31850	COG0640	Transcriptional regulator
NF554_RS31855	COG2197	response regulator
NF554_RS31860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NF554_RS31865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NF554_RS31870	COG0504	CTP synthase activity
NF554_RS31890	COG1181	Belongs to the D-alanine--D-alanine ligase family
NF554_RS31905	COG1181	Belongs to the D-alanine--D-alanine ligase family
NF554_RS31910	COG1132	(ABC) transporter
NF554_RS31915	COG1132	(ABC) transporter
NF554_RS31950	COG0640	Transcriptional regulator
NF554_RS31955	COG1309	transcriptional regulator
NF554_RS31960	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS31970	COG0446	pyridine nucleotide-disulphide oxidoreductase
NF554_RS31970	COG1902	pentaerythritol trinitrate reductase activity
NF554_RS32005	COG3842	ATPase activity
NF554_RS32025	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NF554_RS32030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS32040	COG1120	ATPase activity
NF554_RS32060	COG1132	(ABC) transporter
NF554_RS32065	COG2382	esterase
NF554_RS32085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NF554_RS32115	COG1349	DNA-binding transcription factor activity
NF554_RS32130	COG0395	ABC-type sugar transport system, permease component
NF554_RS32175	COG1470	cell adhesion involved in biofilm formation
NF554_RS32200	COG3845	ABC transporter
NF554_RS32235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NF554_RS32255	COG3433	isochorismatase activity
NF554_RS32255	COG1535	isochorismatase
NF554_RS32260	COG3433	isochorismatase activity
NF554_RS32260	COG1535	isochorismatase
NF554_RS32265	COG1021	2,3-dihydroxybenzoate-AMP ligase
NF554_RS32270	COG1169	isochorismate synthase
NF554_RS32275	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS32280	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NF554_RS32285	COG2382	esterase
NF554_RS32290	COG0477	Major facilitator Superfamily
NF554_RS32300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS32310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NF554_RS32315	COG1120	ATPase activity
NF554_RS32340	COG2365	Tyrosine phosphatase family
NF554_RS32400	COG2080	2 iron, 2 sulfur cluster binding
NF554_RS32405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NF554_RS32410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NF554_RS32420	COG1012	belongs to the aldehyde dehydrogenase family
NF554_RS32425	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NF554_RS32430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NF554_RS32445	COG2066	Belongs to the glutaminase family
NF554_RS32445	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NF554_RS32450	COG2356	endonuclease I
NF554_RS32465	COG2813	Specifically methylates the guanine in position
NF554_RS32470	COG1960	acyl-CoA dehydrogenase activity
NF554_RS32475	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS32475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NF554_RS32475	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS32475	COG3321	synthase
NF554_RS32475	COG0300	oxidoreductase activity
NF554_RS32480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS32480	COG3321	synthase
NF554_RS32480	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NF554_RS32480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NF554_RS32480	COG3321	synthase
NF554_RS32480	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NF554_RS32480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS32480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NF554_RS32495	COG3321	synthase
NF554_RS32495	COG0604	alcohol dehydrogenase
NF554_RS32500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NF554_RS32515	COG0346	lactoylglutathione lyase activity
NF554_RS32540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NF554_RS32545	COG2070	2-Nitropropane dioxygenase
NF554_RS32555	COG2366	antibiotic biosynthetic process
NF554_RS32560	COG0318	PFAM AMP-dependent synthetase and ligase
NF554_RS32570	COG0765	amino acid transport
NF554_RS32595	COG1024	Enoyl-CoA hydratase
NF554_RS32655	COG0254	rRNA binding
NF554_RS32715	COG0681	Belongs to the peptidase S26 family
NF554_RS32730	COG1105	Belongs to the carbohydrate kinase PfkB family
NF554_RS32735	COG1349	DNA-binding transcription factor activity
NF554_RS32790	COG1175	transmembrane transport
NF554_RS32795	COG0395	ABC-type sugar transport system, permease component
NF554_RS32800	COG0366	Alpha amylase catalytic
NF554_RS32805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NF554_RS32825	COG0642	Histidine kinase
NF554_RS32855	COG0702	epimerase
NF554_RS32885	COG0640	Transcriptional regulator
NF554_RS32890	COG1902	pentaerythritol trinitrate reductase activity
NF554_RS32900	COG0277	FAD linked oxidase domain protein
NF554_RS32925	COG0789	Transcriptional regulator
NF554_RS32940	COG1846	Transcriptional regulator
NF554_RS32950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NF554_RS32955	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NF554_RS33030	COG1028	Short-chain dehydrogenase reductase Sdr
NF554_RS33035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NF554_RS33045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NF554_RS33050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NF554_RS33060	COG2050	protein possibly involved in aromatic compounds catabolism
NF554_RS33065	COG0477	Major facilitator Superfamily
NF554_RS33070	COG0367	asparagine synthase