locus-tag	class	description
DTW94_RS00010	COG1505	serine-type exopeptidase activity
DTW94_RS00040	COG0367	asparagine synthase
DTW94_RS00045	COG0477	Major facilitator Superfamily
DTW94_RS00050	COG2050	protein possibly involved in aromatic compounds catabolism
DTW94_RS00060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTW94_RS00065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS00075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS00080	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS00150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DTW94_RS00155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTW94_RS00165	COG1846	Transcriptional regulator
DTW94_RS00170	COG1764	response to oxidative stress
DTW94_RS00180	COG0789	Transcriptional regulator
DTW94_RS00205	COG0277	FAD linked oxidase domain protein
DTW94_RS00220	COG1902	pentaerythritol trinitrate reductase activity
DTW94_RS00225	COG0640	Transcriptional regulator
DTW94_RS00230	COG1064	alcohol dehydrogenase
DTW94_RS00255	COG0702	epimerase
DTW94_RS00285	COG0642	Histidine kinase
DTW94_RS00305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DTW94_RS00310	COG0366	Alpha amylase catalytic
DTW94_RS00315	COG0395	ABC-type sugar transport system, permease component
DTW94_RS00320	COG1175	transmembrane transport
DTW94_RS00365	COG1349	DNA-binding transcription factor activity
DTW94_RS00370	COG1105	Belongs to the carbohydrate kinase PfkB family
DTW94_RS00445	COG0254	rRNA binding
DTW94_RS00505	COG1024	Enoyl-CoA hydratase
DTW94_RS00530	COG0765	amino acid transport
DTW94_RS00540	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS00545	COG2366	antibiotic biosynthetic process
DTW94_RS00555	COG2070	2-Nitropropane dioxygenase
DTW94_RS00570	COG0515	serine threonine protein kinase
DTW94_RS00585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DTW94_RS00590	COG0346	lactoylglutathione lyase activity
DTW94_RS00605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS00615	COG3321	synthase
DTW94_RS00615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS00615	COG3321	synthase
DTW94_RS00615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DTW94_RS00615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTW94_RS00615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTW94_RS00615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS00615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DTW94_RS00620	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS00620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS00620	COG3321	synthase
DTW94_RS00620	COG0300	oxidoreductase activity
DTW94_RS00625	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS00630	COG2813	Specifically methylates the guanine in position
DTW94_RS00645	COG2356	endonuclease I
DTW94_RS00650	COG2066	Belongs to the glutaminase family
DTW94_RS00650	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DTW94_RS00665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTW94_RS00670	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DTW94_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS00685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DTW94_RS00690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DTW94_RS00695	COG2080	2 iron, 2 sulfur cluster binding
DTW94_RS00755	COG2365	Tyrosine phosphatase family
DTW94_RS00780	COG1120	ATPase activity
DTW94_RS00785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DTW94_RS00795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS00805	COG0477	Major facilitator Superfamily
DTW94_RS00810	COG2382	esterase
DTW94_RS00815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS00825	COG1169	isochorismate synthase
DTW94_RS00830	COG1021	2,3-dihydroxybenzoate-AMP ligase
DTW94_RS00835	COG1535	isochorismatase
DTW94_RS00835	COG3433	isochorismatase activity
DTW94_RS00840	COG1535	isochorismatase
DTW94_RS00840	COG3433	isochorismatase activity
DTW94_RS00920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DTW94_RS00955	COG3845	ABC transporter
DTW94_RS00980	COG1470	cell adhesion involved in biofilm formation
DTW94_RS01015	COG1063	alcohol dehydrogenase
DTW94_RS01020	COG0395	ABC-type sugar transport system, permease component
DTW94_RS01035	COG1349	DNA-binding transcription factor activity
DTW94_RS01065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DTW94_RS01085	COG2382	esterase
DTW94_RS01090	COG1132	(ABC) transporter
DTW94_RS01100	COG1132	(ABC) transporter
DTW94_RS01110	COG1120	ATPase activity
DTW94_RS01115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS01120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS01125	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DTW94_RS01200	COG0640	Transcriptional regulator
DTW94_RS01235	COG1132	(ABC) transporter
DTW94_RS01240	COG1132	(ABC) transporter
DTW94_RS01245	COG1181	Belongs to the D-alanine--D-alanine ligase family
DTW94_RS01260	COG1181	Belongs to the D-alanine--D-alanine ligase family
DTW94_RS01280	COG0504	CTP synthase activity
DTW94_RS01285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DTW94_RS01290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DTW94_RS01295	COG2197	response regulator
DTW94_RS01300	COG0640	Transcriptional regulator
DTW94_RS01305	COG0243	molybdopterin cofactor binding
DTW94_RS01330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DTW94_RS01335	COG0573	inorganic phosphate transmembrane transporter activity
DTW94_RS01340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DTW94_RS01345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DTW94_RS01350	COG0798	PFAM Bile acid sodium symporter
DTW94_RS01360	COG2226	methyltransferase
DTW94_RS01370	COG0583	DNA-binding transcription factor activity
DTW94_RS01375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DTW94_RS01385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTW94_RS01395	COG1116	anion transmembrane transporter activity
DTW94_RS01440	COG0640	Transcriptional regulator
DTW94_RS01445	COG3293	Transposase
DTW94_RS01475	COG1191	sigma factor activity
DTW94_RS01510	COG0297	glycogen (starch) synthase activity
DTW94_RS01530	COG0531	amino acid
DTW94_RS01545	COG1982	Orn Lys Arg decarboxylase major
DTW94_RS01580	COG2376	Dihydroxyacetone kinase
DTW94_RS01585	COG1461	Dihydroxyacetone kinase
DTW94_RS01600	COG0488	(ABC) transporter
DTW94_RS01630	COG1191	sigma factor activity
DTW94_RS01640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DTW94_RS01645	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DTW94_RS01660	COG1120	ATPase activity
DTW94_RS01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS01690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS01735	COG1063	alcohol dehydrogenase
DTW94_RS01740	COG1295	ribonuclease BN
DTW94_RS01740	COG1959	2 iron, 2 sulfur cluster binding
DTW94_RS01770	COG2837	iron assimilation
DTW94_RS01775	COG1120	ATPase activity
DTW94_RS01780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS01785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS01805	COG0617	tRNA 3'-terminal CCA addition
DTW94_RS01810	COG2207	Transcriptional regulator
DTW94_RS01825	COG0366	Alpha amylase catalytic
DTW94_RS01825	COG1874	Beta-galactosidase
DTW94_RS01840	COG1609	Transcriptional regulator
DTW94_RS01845	COG1172	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS01855	COG1129	ABC transporter
DTW94_RS01860	COG1879	ABC-type sugar transport system periplasmic component
DTW94_RS01865	COG3250	beta-galactosidase activity
DTW94_RS01910	COG0328	RNA-DNA hybrid ribonuclease activity
DTW94_RS01915	COG1132	(ABC) transporter
DTW94_RS01925	COG2264	protein methyltransferase activity
DTW94_RS01975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTW94_RS02035	COG2045	Belongs to the ComB family
DTW94_RS02055	COG0464	growth
DTW94_RS02065	COG1349	DNA-binding transcription factor activity
DTW94_RS02080	COG0702	epimerase
DTW94_RS02120	COG1940	carbohydrate kinase activity
DTW94_RS02125	COG2223	nitrite transmembrane transporter activity
DTW94_RS02165	COG0445	tRNA wobble uridine modification
DTW94_RS02180	COG1660	Displays ATPase and GTPase activities
DTW94_RS02185	COG1940	carbohydrate kinase activity
DTW94_RS02205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DTW94_RS02250	COG0584	glycerophosphoryl diester phosphodiesterase
DTW94_RS02255	COG0456	acetyltransferase
DTW94_RS02270	COG0671	phosphoesterase, PA-phosphatase related
DTW94_RS02325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DTW94_RS02330	COG2971	BadF BadG BcrA BcrD
DTW94_RS02340	COG2706	6-phosphogluconolactonase activity
DTW94_RS02365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTW94_RS02370	COG2815	serine threonine protein kinase
DTW94_RS02370	COG0515	serine threonine protein kinase
DTW94_RS02375	COG0667	Aldo Keto reductase
DTW94_RS02405	COG1253	flavin adenine dinucleotide binding
DTW94_RS02445	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DTW94_RS02450	COG0531	amino acid
DTW94_RS02455	COG2186	Transcriptional regulator
DTW94_RS02460	COG0174	glutamine synthetase
DTW94_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS02475	COG1609	Transcriptional regulator
DTW94_RS02480	COG1653	transport
DTW94_RS02485	COG1175	transmembrane transport
DTW94_RS02495	COG1472	Belongs to the glycosyl hydrolase 3 family
DTW94_RS02525	COG4981	capsule polysaccharide biosynthetic process
DTW94_RS02545	COG2835	tetraacyldisaccharide 4'-kinase activity
DTW94_RS02555	COG0745	RESPONSE REGULATOR receiver
DTW94_RS02575	COG0243	molybdopterin cofactor binding
DTW94_RS02600	COG1357	PFAM Pentapeptide repeats (8 copies)
DTW94_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS02610	COG1982	Orn Lys Arg decarboxylase major
DTW94_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS02680	COG2124	cytochrome p450
DTW94_RS02695	COG1335	isochorismatase
DTW94_RS02750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTW94_RS02755	COG0542	response to heat
DTW94_RS02770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS02775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS02785	COG4592	Periplasmic binding protein
DTW94_RS02815	COG0385	Bile acid
DTW94_RS02845	COG0583	DNA-binding transcription factor activity
DTW94_RS02865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DTW94_RS02885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTW94_RS02890	COG1116	anion transmembrane transporter activity
DTW94_RS02900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS02905	COG2072	flavoprotein involved in K transport
DTW94_RS02920	COG1132	(ABC) transporter
DTW94_RS02930	COG0277	FAD linked oxidase domain protein
DTW94_RS02940	COG1132	(ABC) transporter
DTW94_RS02945	COG1132	(ABC) transporter
DTW94_RS02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DTW94_RS02970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DTW94_RS02985	COG1252	NADH dehydrogenase
DTW94_RS02990	COG1793	dna ligase
DTW94_RS03005	COG1946	Acyl-CoA thioesterase
DTW94_RS03020	COG0386	Belongs to the glutathione peroxidase family
DTW94_RS03025	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS03035	COG0242	peptide deformylase activity
DTW94_RS03045	COG3442	glutamine amidotransferase
DTW94_RS03050	COG0205	6-phosphofructokinase activity
DTW94_RS03080	COG0829	nickel cation binding
DTW94_RS03085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DTW94_RS03095	COG0804	urea catabolic process
DTW94_RS03100	COG0832	Belongs to the urease beta subunit family
DTW94_RS03105	COG0831	urea catabolic process
DTW94_RS03150	COG0156	8-amino-7-oxononanoate synthase activity
DTW94_RS03155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DTW94_RS03160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DTW94_RS03165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DTW94_RS03170	COG2226	methyltransferase
DTW94_RS03195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DTW94_RS03200	COG3663	DNA glycosylase
DTW94_RS03210	COG1940	carbohydrate kinase activity
DTW94_RS03215	COG2188	Transcriptional regulator
DTW94_RS03220	COG1595	DNA-templated transcription, initiation
DTW94_RS03250	COG0626	cystathionine gamma-synthase activity
DTW94_RS03270	COG1522	sequence-specific DNA binding
DTW94_RS03275	COG0419	ATPase involved in DNA repair
DTW94_RS03280	COG0420	3'-5' exonuclease activity
DTW94_RS03285	COG1739	Uncharacterized protein family UPF0029
DTW94_RS03290	COG1832	CoA-binding protein
DTW94_RS03330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DTW94_RS03345	COG1968	undecaprenyl-diphosphatase activity
DTW94_RS03355	COG2226	methyltransferase
DTW94_RS03360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DTW94_RS03410	COG2318	DinB family
DTW94_RS03425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DTW94_RS03505	COG1404	Belongs to the peptidase S8 family
DTW94_RS03540	COG0583	DNA-binding transcription factor activity
DTW94_RS03570	COG0697	spore germination
DTW94_RS03655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DTW94_RS03655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DTW94_RS03665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DTW94_RS03685	COG1716	ATPase activity
DTW94_RS03705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DTW94_RS03740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DTW94_RS03750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTW94_RS03765	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DTW94_RS03795	COG2018	Roadblock/LC7 domain
DTW94_RS03870	COG2364	Membrane
DTW94_RS03880	COG2270	Major facilitator Superfamily
DTW94_RS03890	COG3030	protein affecting phage T7 exclusion by the F plasmid
DTW94_RS03895	COG1216	Glycosyl transferase, family 2
DTW94_RS03920	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS03965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DTW94_RS03970	COG0140	phosphoribosyl-ATP diphosphatase activity
DTW94_RS03975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DTW94_RS03985	COG3201	nicotinamide mononucleotide transporter
DTW94_RS04010	COG0738	Major facilitator superfamily
DTW94_RS04015	COG2233	PERMEase
DTW94_RS04030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DTW94_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS04055	COG2390	Transcriptional regulator
DTW94_RS04060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DTW94_RS04070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DTW94_RS04085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DTW94_RS04095	COG1758	RNA polymerase activity
DTW94_RS04110	COG0284	orotidine-5'-phosphate decarboxylase activity
DTW94_RS04115	COG0167	dihydroorotate dehydrogenase activity
DTW94_RS04120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DTW94_RS04125	COG0505	Belongs to the CarA family
DTW94_RS04135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DTW94_RS04140	COG0540	Belongs to the ATCase OTCase family
DTW94_RS04145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DTW94_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DTW94_RS04160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DTW94_RS04165	COG0006	proline dipeptidase activity
DTW94_RS04175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DTW94_RS04180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DTW94_RS04185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DTW94_RS04190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DTW94_RS04205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DTW94_RS04210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DTW94_RS04230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DTW94_RS04250	COG0124	histidyl-tRNA synthetase
DTW94_RS04265	COG1196	nuclear chromosome segregation
DTW94_RS04270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DTW94_RS04275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DTW94_RS04280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTW94_RS04285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTW94_RS04295	COG2255	four-way junction helicase activity
DTW94_RS04300	COG0632	four-way junction helicase activity
DTW94_RS04305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DTW94_RS04310	COG0217	transcriptional regulatory protein
DTW94_RS04315	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DTW94_RS04320	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DTW94_RS04330	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS04335	COG1560	Kdo2-lipid A biosynthetic process
DTW94_RS04340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DTW94_RS04365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DTW94_RS04380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DTW94_RS04435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DTW94_RS04490	COG1648	precorrin-2 dehydrogenase activity
DTW94_RS04490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DTW94_RS04495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DTW94_RS04510	COG1464	Belongs to the NlpA lipoprotein family
DTW94_RS04515	COG2011	ABC-type metal ion transport system permease component
DTW94_RS04555	COG0477	Major facilitator Superfamily
DTW94_RS04565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DTW94_RS04570	COG3973	AAA domain
DTW94_RS04580	COG0165	Argininosuccinate lyase
DTW94_RS04585	COG0137	argininosuccinate synthase activity
DTW94_RS04595	COG1438	arginine binding
DTW94_RS04600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DTW94_RS04605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DTW94_RS04610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DTW94_RS04615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DTW94_RS04665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DTW94_RS04680	COG0697	spore germination
DTW94_RS04690	COG1649	PFAM Uncharacterised BCR, COG1649
DTW94_RS04710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DTW94_RS04710	COG0072	phenylalanine-tRNA ligase activity
DTW94_RS04715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DTW94_RS04720	COG5002	protein histidine kinase activity
DTW94_RS04725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DTW94_RS04730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DTW94_RS04735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DTW94_RS04740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DTW94_RS04810	COG0517	IMP dehydrogenase activity
DTW94_RS04810	COG4175	Glycine betaine
DTW94_RS04815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DTW94_RS04840	COG1595	DNA-templated transcription, initiation
DTW94_RS04860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DTW94_RS04865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DTW94_RS04905	COG0805	protein transport
DTW94_RS04910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DTW94_RS04930	COG2378	regulation of single-species biofilm formation
DTW94_RS04940	COG0545	Peptidyl-prolyl cis-trans isomerase
DTW94_RS04945	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DTW94_RS04955	COG1609	Transcriptional regulator
DTW94_RS04960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DTW94_RS04965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DTW94_RS04980	COG4122	O-methyltransferase activity
DTW94_RS04985	COG1222	aaa ATPase
DTW94_RS05010	COG1994	Peptidase M50
DTW94_RS05010	COG0517	IMP dehydrogenase activity
DTW94_RS05020	COG2197	response regulator
DTW94_RS05025	COG4166	transmembrane transport
DTW94_RS05035	COG0646	methionine synthase
DTW94_RS05035	COG1410	methionine synthase
DTW94_RS05040	COG1414	Transcriptional regulator
DTW94_RS05045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DTW94_RS05050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DTW94_RS05055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DTW94_RS05060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS05070	COG0215	cysteine-tRNA ligase activity
DTW94_RS05090	COG0598	Magnesium transport protein CorA
DTW94_RS05100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS05105	COG0667	Aldo Keto reductase
DTW94_RS05135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DTW94_RS05145	COG0564	pseudouridine synthase activity
DTW94_RS05160	COG2186	Transcriptional regulator
DTW94_RS05165	COG3265	gluconokinase activity
DTW94_RS05195	COG3573	Dehydrogenase
DTW94_RS05200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DTW94_RS05205	COG2149	membrane
DTW94_RS05225	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS05230	COG4935	Belongs to the peptidase S8 family
DTW94_RS05230	COG2234	aminopeptidase activity
DTW94_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS05250	COG3876	Protein conserved in bacteria
DTW94_RS05270	COG0789	Transcriptional regulator
DTW94_RS05290	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS05300	COG2326	polyphosphate kinase activity
DTW94_RS05320	COG2851	Citrate transporter
DTW94_RS05325	COG0243	molybdopterin cofactor binding
DTW94_RS05330	COG1309	transcriptional regulator
DTW94_RS05335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DTW94_RS05340	COG2188	Transcriptional regulator
DTW94_RS05350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTW94_RS05360	COG2755	lipolytic protein G-D-S-L family
DTW94_RS05370	COG1725	Transcriptional regulator
DTW94_RS05385	COG0346	lactoylglutathione lyase activity
DTW94_RS05405	COG4565	transcriptional regulatory protein
DTW94_RS05425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DTW94_RS05430	COG0587	DNA-directed DNA polymerase activity
DTW94_RS05460	COG0641	radical SAM
DTW94_RS05490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS05500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS05520	COG0765	amino acid transport
DTW94_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS05535	COG1799	cell septum assembly
DTW94_RS05540	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS05545	COG0477	Major facilitator Superfamily
DTW94_RS05550	COG0671	phosphoesterase, PA-phosphatase related
DTW94_RS05570	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS05585	COG1160	GTP binding
DTW94_RS05595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DTW94_RS05615	COG3541	Predicted nucleotidyltransferase
DTW94_RS05620	COG3541	Predicted nucleotidyltransferase
DTW94_RS05630	COG0494	nUDIX hydrolase
DTW94_RS05645	COG1187	pseudouridine synthase activity
DTW94_RS05650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DTW94_RS05655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DTW94_RS05670	COG0686	Belongs to the AlaDH PNT family
DTW94_RS05680	COG0494	nUDIX hydrolase
DTW94_RS05685	COG0504	CTP synthase activity
DTW94_RS05690	COG3387	PFAM Glycoside hydrolase 15-related
DTW94_RS05710	COG3119	arylsulfatase activity
DTW94_RS05715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DTW94_RS05725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS05730	COG0601	transmembrane transport
DTW94_RS05735	COG4166	transmembrane transport
DTW94_RS05765	COG0497	DNA recombination
DTW94_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DTW94_RS05790	COG1120	ATPase activity
DTW94_RS05795	COG0647	UMP catabolic process
DTW94_RS05825	COG2094	Belongs to the DNA glycosylase MPG family
DTW94_RS05835	COG1881	PFAM PEBP family protein
DTW94_RS05860	COG1119	ATPase activity
DTW94_RS05870	COG2197	response regulator
DTW94_RS05885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DTW94_RS05895	COG1131	(ABC) transporter
DTW94_RS05895	COG1716	ATPase activity
DTW94_RS05895	COG0842	Transport permease protein
DTW94_RS05900	COG0560	Phosphoserine phosphatase
DTW94_RS05900	COG3830	Belongs to the UPF0237 family
DTW94_RS05920	COG2186	Transcriptional regulator
DTW94_RS05930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DTW94_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS05950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DTW94_RS05955	COG2261	transglycosylase associated protein
DTW94_RS05970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DTW94_RS05975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTW94_RS06010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DTW94_RS06025	COG3387	PFAM Glycoside hydrolase 15-related
DTW94_RS06065	COG1024	Enoyl-CoA hydratase
DTW94_RS06075	COG0488	(ABC) transporter
DTW94_RS06100	COG0235	Class ii aldolase
DTW94_RS06115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DTW94_RS06120	COG1492	cobalamin metabolic process
DTW94_RS06135	COG1797	cobyrinic acid a,c-diamide synthase activity
DTW94_RS06160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DTW94_RS06190	COG1902	pentaerythritol trinitrate reductase activity
DTW94_RS06195	COG1846	Transcriptional regulator
DTW94_RS06230	COG0768	penicillin binding
DTW94_RS06235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS06245	COG0431	NADPH-dependent FMN reductase
DTW94_RS06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DTW94_RS06295	COG2171	N-acyltransferase activity
DTW94_RS06315	COG3226	Transcriptional regulator
DTW94_RS06340	COG2151	metal-sulfur cluster biosynthetic enzyme
DTW94_RS06345	COG0822	iron-sulfur transferase activity
DTW94_RS06350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DTW94_RS06355	COG0396	ATPase activity
DTW94_RS06365	COG0719	Fe-S assembly protein
DTW94_RS06380	COG1131	(ABC) transporter
DTW94_RS06390	COG1612	heme a metabolic process
DTW94_RS06400	COG0109	protoheme IX farnesyltransferase activity
DTW94_RS06410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DTW94_RS06425	COG0363	glucosamine-6-phosphate deaminase activity
DTW94_RS06435	COG4195	phage-related replication protein
DTW94_RS06450	COG0166	Belongs to the GPI family
DTW94_RS06460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DTW94_RS06465	COG0149	triose-phosphate isomerase activity
DTW94_RS06470	COG0126	phosphoglycerate kinase activity
DTW94_RS06475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DTW94_RS06480	COG1481	regulation of sporulation
DTW94_RS06485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DTW94_RS06490	COG1660	Displays ATPase and GTPase activities
DTW94_RS06495	COG0322	excinuclease ABC activity
DTW94_RS06520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DTW94_RS06550	COG0556	nucleotide-excision repair
DTW94_RS06560	COG0584	glycerophosphoryl diester phosphodiesterase
DTW94_RS06565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DTW94_RS06575	COG2814	Major facilitator Superfamily
DTW94_RS06585	COG2313	pseudouridylate synthase activity
DTW94_RS06595	COG1473	amidohydrolase
DTW94_RS06615	COG0436	Aminotransferase
DTW94_RS06635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DTW94_RS06660	COG0237	dephospho-CoA kinase activity
DTW94_RS06680	COG2226	methyltransferase
DTW94_RS06685	COG1643	Atp-dependent helicase
DTW94_RS06720	COG2050	protein possibly involved in aromatic compounds catabolism
DTW94_RS06775	COG0737	Belongs to the 5'-nucleotidase family
DTW94_RS06795	COG0659	secondary active sulfate transmembrane transporter activity
DTW94_RS06805	COG2824	Alkylphosphonate utilization operon protein PhnA
DTW94_RS06825	COG1605	Chorismate mutase
DTW94_RS06825	COG0287	Prephenate dehydrogenase
DTW94_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS06870	COG1024	Enoyl-CoA hydratase
DTW94_RS06895	COG1278	Cold shock
DTW94_RS06900	COG0183	Belongs to the thiolase family
DTW94_RS06905	COG1309	transcriptional regulator
DTW94_RS06915	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS06920	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS06935	COG2304	oxidoreductase activity
DTW94_RS06940	COG0705	Rhomboid family
DTW94_RS06950	COG0069	glutamate synthase activity
DTW94_RS06950	COG0067	glutamate synthase
DTW94_RS06950	COG0070	glutamate synthase
DTW94_RS06960	COG1397	ADP-ribosylglycohydrolase
DTW94_RS06980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DTW94_RS06985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTW94_RS06995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DTW94_RS07005	COG0159	tryptophan synthase activity
DTW94_RS07010	COG0133	tryptophan synthase activity
DTW94_RS07020	COG0134	indole-3-glycerol-phosphate synthase activity
DTW94_RS07040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DTW94_RS07045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DTW94_RS07055	COG2508	Transcriptional regulator
DTW94_RS07070	COG0107	imidazoleglycerol-phosphate synthase activity
DTW94_RS07075	COG0251	oxidation-reduction process
DTW94_RS07080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DTW94_RS07085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DTW94_RS07090	COG0131	Imidazoleglycerol-phosphate dehydratase
DTW94_RS07095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DTW94_RS07100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DTW94_RS07115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DTW94_RS07140	COG1432	Conserved Protein
DTW94_RS07150	COG0587	DNA-directed DNA polymerase activity
DTW94_RS07200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DTW94_RS07215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DTW94_RS07220	COG3599	regulation of cell shape
DTW94_RS07230	COG1799	cell septum assembly
DTW94_RS07235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DTW94_RS07260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DTW94_RS07270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DTW94_RS07275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DTW94_RS07285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DTW94_RS07290	COG0768	penicillin binding
DTW94_RS07300	COG0275	rRNA processing
DTW94_RS07310	COG0714	Associated with various cellular activities
DTW94_RS07330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DTW94_RS07340	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DTW94_RS07345	COG1511	domain protein
DTW94_RS07375	COG0352	thiamine-phosphate diphosphorylase activity
DTW94_RS07395	COG2022	thiamine diphosphate biosynthetic process
DTW94_RS07395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTW94_RS07405	COG2022	thiamine diphosphate biosynthetic process
DTW94_RS07410	COG2815	serine threonine protein kinase
DTW94_RS07410	COG0515	serine threonine protein kinase
DTW94_RS07415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DTW94_RS07420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DTW94_RS07425	COG2193	ferroxidase activity
DTW94_RS07435	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DTW94_RS07450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTW94_RS07455	COG2197	response regulator
DTW94_RS07460	COG4585	Histidine kinase
DTW94_RS07485	COG1940	carbohydrate kinase activity
DTW94_RS07495	COG0003	Pfam Anion-transporting ATPase
DTW94_RS07560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DTW94_RS07565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DTW94_RS07570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DTW94_RS07575	COG0723	plastoquinol--plastocyanin reductase activity
DTW94_RS07580	COG2010	Cytochrome c
DTW94_RS07585	COG1845	cytochrome c oxidase, subunit III
DTW94_RS07595	COG1376	ErfK ybiS ycfS ynhG family protein
DTW94_RS07605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DTW94_RS07610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DTW94_RS07615	COG1104	cysteine desulfurase activity
DTW94_RS07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DTW94_RS07640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DTW94_RS07650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DTW94_RS07655	COG2197	response regulator
DTW94_RS07660	COG4585	Histidine kinase
DTW94_RS07685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTW94_RS07700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DTW94_RS07720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DTW94_RS07725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DTW94_RS07730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DTW94_RS07735	COG0508	dehydrogenase complex catalyzes the overall conversion of
DTW94_RS07745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DTW94_RS07765	COG1090	epimerase
DTW94_RS07780	COG0321	lipoyl(octanoyl) transferase activity
DTW94_RS07785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DTW94_RS07840	COG1846	Transcriptional regulator
DTW94_RS07875	COG0745	RESPONSE REGULATOR receiver
DTW94_RS07885	COG2197	response regulator
DTW94_RS07945	COG0366	Alpha amylase catalytic
DTW94_RS07950	COG3833	ABC-type maltose transport systems, permease component
DTW94_RS07955	COG1175	transmembrane transport
DTW94_RS07965	COG1609	Transcriptional regulator
DTW94_RS07980	COG0531	amino acid
DTW94_RS07990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DTW94_RS07995	COG2890	protein-(glutamine-N5) methyltransferase activity
DTW94_RS08000	COG0454	-acetyltransferase
DTW94_RS08000	COG0456	acetyltransferase
DTW94_RS08055	COG0546	phosphoglycolate phosphatase activity
DTW94_RS08095	COG0174	glutamine synthetase
DTW94_RS08110	COG2132	Multicopper oxidase
DTW94_RS08115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DTW94_RS08115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DTW94_RS08120	COG2814	Major facilitator Superfamily
DTW94_RS08135	COG0477	Major facilitator Superfamily
DTW94_RS08140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DTW94_RS08160	COG1994	Peptidase M50
DTW94_RS08200	COG5398	heme oxygenase
DTW94_RS08220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DTW94_RS08225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS08230	COG1120	ATPase activity
DTW94_RS08250	COG1834	amidinotransferase
DTW94_RS08270	COG2814	Major facilitator Superfamily
DTW94_RS08280	COG3540	Alkaline phosphatase
DTW94_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS08295	COG0384	phenazine biosynthesis protein PhzF
DTW94_RS08320	COG2273	Hydrolase Family 16
DTW94_RS08350	COG3022	response to hydroperoxide
DTW94_RS08355	COG0800	Aldolase
DTW94_RS08375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DTW94_RS08380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DTW94_RS08400	COG2030	dehydratase
DTW94_RS08410	COG0183	Belongs to the thiolase family
DTW94_RS08415	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS08420	COG3903	Transcriptional regulator
DTW94_RS08420	COG3629	intracellular signal transduction
DTW94_RS08435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTW94_RS08440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTW94_RS08450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS08465	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS08475	COG0655	NAD(P)H dehydrogenase (quinone) activity
DTW94_RS08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS08540	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS08545	COG1309	transcriptional regulator
DTW94_RS08615	COG3845	ABC transporter
DTW94_RS08625	COG0183	Belongs to the thiolase family
DTW94_RS08630	COG2124	cytochrome p450
DTW94_RS08680	COG2259	Doxx family
DTW94_RS08725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DTW94_RS08760	COG1358	cellular component organization or biogenesis
DTW94_RS08810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DTW94_RS08825	COG0477	Major facilitator Superfamily
DTW94_RS08830	COG1309	transcriptional regulator
DTW94_RS08845	COG4585	Histidine kinase
DTW94_RS08850	COG2197	response regulator
DTW94_RS08865	COG0667	Aldo Keto reductase
DTW94_RS08870	COG0789	Transcriptional regulator
DTW94_RS08895	COG1741	Belongs to the pirin family
DTW94_RS08910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS08915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS08920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS08945	COG1309	transcriptional regulator
DTW94_RS08955	COG1764	response to oxidative stress
DTW94_RS08960	COG2130	NADP-dependent
DTW94_RS08990	COG1522	sequence-specific DNA binding
DTW94_RS09000	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS09005	COG0825	malonyl-CoA metabolic process
DTW94_RS09005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DTW94_RS09015	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS09025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DTW94_RS09050	COG1070	Carbohydrate kinase
DTW94_RS09065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DTW94_RS09070	COG0358	DNA primase activity
DTW94_RS09075	COG2226	methyltransferase
DTW94_RS09085	COG0477	Major facilitator Superfamily
DTW94_RS09095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DTW94_RS09150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DTW94_RS09150	COG2146	nitrite reductase [NAD(P)H] activity
DTW94_RS09155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DTW94_RS09155	COG2146	nitrite reductase [NAD(P)H] activity
DTW94_RS09175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DTW94_RS09175	COG0574	Belongs to the PEP-utilizing enzyme family
DTW94_RS09185	COG3842	ATPase activity
DTW94_RS09190	COG2011	ABC-type metal ion transport system permease component
DTW94_RS09205	COG2188	Transcriptional regulator
DTW94_RS09265	COG4942	peptidase
DTW94_RS09310	COG2066	Belongs to the glutaminase family
DTW94_RS09355	COG1733	regulation of RNA biosynthetic process
DTW94_RS09360	COG0702	epimerase
DTW94_RS09375	COG2197	response regulator
DTW94_RS09405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DTW94_RS09435	COG0423	glycine-tRNA ligase activity
DTW94_RS09440	COG0803	Belongs to the bacterial solute-binding protein 9 family
DTW94_RS09440	COG3443	Belongs to the bacterial solute-binding protein 9 family
DTW94_RS09445	COG1121	(ABC) transporter
DTW94_RS09450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DTW94_RS09460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DTW94_RS09465	COG1381	Involved in DNA repair and RecF pathway recombination
DTW94_RS09475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTW94_RS09490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DTW94_RS09500	COG2315	Protein conserved in bacteria
DTW94_RS09510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DTW94_RS09520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DTW94_RS09530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DTW94_RS09535	COG1234	tRNA 3'-trailer cleavage
DTW94_RS09540	COG0537	adenosine 5'-monophosphoramidase activity
DTW94_RS09555	COG0484	heat shock protein binding
DTW94_RS09560	COG1420	regulation of RNA biosynthetic process
DTW94_RS09590	COG1022	Amp-dependent synthetase and ligase
DTW94_RS09595	COG0481	GTPase activity
DTW94_RS09600	COG0268	Binds directly to 16S ribosomal RNA
DTW94_RS09615	COG2353	YceI-like domain
DTW94_RS09625	COG1555	photosystem II stabilization
DTW94_RS09630	COG1307	EDD domain protein, DegV family
DTW94_RS09640	COG0495	leucyl-tRNA aminoacylation
DTW94_RS09675	COG0588	phosphoglycerate mutase activity
DTW94_RS09680	COG0799	negative regulation of ribosome biogenesis
DTW94_RS09690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DTW94_RS09695	COG0501	Belongs to the peptidase M48B family
DTW94_RS09710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DTW94_RS09720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DTW94_RS09745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DTW94_RS09750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DTW94_RS09755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DTW94_RS09795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DTW94_RS09800	COG1530	ribonuclease E activity
DTW94_RS09825	COG0772	Belongs to the SEDS family
DTW94_RS09830	COG0768	penicillin binding
DTW94_RS09845	COG1077	Cell shape determining protein MreB Mrl
DTW94_RS09850	COG0105	UTP biosynthetic process
DTW94_RS09860	COG0285	dihydrofolate synthase activity
DTW94_RS09865	COG0525	valine-tRNA ligase activity
DTW94_RS09875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DTW94_RS09880	COG0740	serine-type endopeptidase activity
DTW94_RS09885	COG0740	serine-type endopeptidase activity
DTW94_RS09890	COG0544	peptidyl-prolyl cis-trans isomerase activity
DTW94_RS09915	COG3594	Acyltransferase
DTW94_RS09920	COG0475	glutathione-regulated potassium exporter activity
DTW94_RS09930	COG4552	Acetyltransferase involved in intracellular survival and related
DTW94_RS09945	COG1113	amino acid transport
DTW94_RS09950	COG1268	BioY protein
DTW94_RS09955	COG1113	amino acid transport
DTW94_RS09960	COG1113	amino acid transport
DTW94_RS09970	COG0783	Belongs to the Dps family
DTW94_RS09975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DTW94_RS09980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DTW94_RS09985	COG0640	Transcriptional regulator
DTW94_RS10000	COG0110	maltose O-acetyltransferase activity
DTW94_RS10010	COG3655	Transcriptional regulator
DTW94_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS10035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DTW94_RS10070	COG4266	Belongs to the allantoicase family
DTW94_RS10090	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DTW94_RS10100	COG0668	transmembrane transport
DTW94_RS10105	COG1940	carbohydrate kinase activity
DTW94_RS10115	COG1175	transmembrane transport
DTW94_RS10120	COG0395	ABC-type sugar transport system, permease component
DTW94_RS10125	COG1486	melibiose metabolic process
DTW94_RS10140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS10170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DTW94_RS10175	COG2346	COG2346, Truncated hemoglobins
DTW94_RS10200	COG0629	single-stranded DNA binding
DTW94_RS10205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DTW94_RS10220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DTW94_RS10300	COG1131	(ABC) transporter
DTW94_RS10315	COG3962	Belongs to the TPP enzyme family
DTW94_RS10320	COG3718	enzyme involved in inositol metabolism
DTW94_RS10340	COG2318	DinB family
DTW94_RS10350	COG3615	Tellurite resistance protein tehB
DTW94_RS10350	COG0500	methyltransferase
DTW94_RS10355	COG2409	Drug exporters of the RND superfamily
DTW94_RS10380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DTW94_RS10465	COG0673	inositol 2-dehydrogenase activity
DTW94_RS10470	COG1609	Transcriptional regulator
DTW94_RS10495	COG0515	serine threonine protein kinase
DTW94_RS10525	COG1404	Belongs to the peptidase S8 family
DTW94_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS10575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS10580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS10585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS10590	COG1472	Belongs to the glycosyl hydrolase 3 family
DTW94_RS10620	COG3960	tartronate-semialdehyde synthase activity
DTW94_RS10640	COG1396	sequence-specific DNA binding
DTW94_RS10660	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS10665	COG1946	Acyl-CoA thioesterase
DTW94_RS10685	COG2755	lipolytic protein G-D-S-L family
DTW94_RS10685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DTW94_RS10690	COG0515	serine threonine protein kinase
DTW94_RS10690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DTW94_RS10705	COG1309	transcriptional regulator
DTW94_RS10710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTW94_RS10720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTW94_RS10725	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS10730	COG2188	Transcriptional regulator
DTW94_RS10735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DTW94_RS10755	COG0076	glutamate decarboxylase activity
DTW94_RS10760	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DTW94_RS10785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DTW94_RS10790	COG0589	response to stress
DTW94_RS10795	COG4977	sequence-specific DNA binding
DTW94_RS10825	COG0395	ABC-type sugar transport system, permease component
DTW94_RS10840	COG2985	domain, Protein
DTW94_RS10880	COG0588	phosphoglycerate mutase activity
DTW94_RS10935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS10950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS10955	COG0765	amino acid transport
DTW94_RS10960	COG0765	amino acid transport
DTW94_RS10965	COG1126	abc transporter atp-binding protein
DTW94_RS10980	COG3397	chitin binding
DTW94_RS11055	COG2188	Transcriptional regulator
DTW94_RS11085	COG0673	inositol 2-dehydrogenase activity
DTW94_RS11090	COG4702	Belongs to the UPF0303 family
DTW94_RS11100	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion
DTW94_RS11100	COG0706	membrane insertase activity
DTW94_RS11110	COG3764	Sortase (surface protein transpeptidase)
DTW94_RS11160	COG1215	transferase activity, transferring glycosyl groups
DTW94_RS11170	COG0745	RESPONSE REGULATOR receiver
DTW94_RS11190	COG3409	Peptidoglycan-binding domain 1 protein
DTW94_RS11200	COG0789	Transcriptional regulator
DTW94_RS11230	COG0697	spore germination
DTW94_RS11245	COG2313	pseudouridylate synthase activity
DTW94_RS11250	COG2733	membrane
DTW94_RS11270	COG4555	ABC transporter
DTW94_RS11285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DTW94_RS11310	COG0477	Major facilitator Superfamily
DTW94_RS11320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DTW94_RS11330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DTW94_RS11335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DTW94_RS11340	COG1263	PTS System
DTW94_RS11345	COG1263	PTS System
DTW94_RS11350	COG1234	tRNA 3'-trailer cleavage
DTW94_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS11395	COG1113	amino acid transport
DTW94_RS11405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DTW94_RS11415	COG1335	isochorismatase
DTW94_RS11450	COG0277	FAD linked oxidase domain protein
DTW94_RS11460	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DTW94_RS11470	COG1174	glycine betaine transport
DTW94_RS11480	COG1174	glycine betaine transport
DTW94_RS11485	COG1732	Glycine betaine
DTW94_RS11490	COG3480	Lon protease (S16) C-terminal proteolytic domain
DTW94_RS11500	COG1061	Type III restriction enzyme res subunit
DTW94_RS11505	COG3654	unkown
DTW94_RS11560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DTW94_RS11565	COG0395	ABC-type sugar transport system, permease component
DTW94_RS11585	COG1678	Uncharacterized ACR, COG1678
DTW94_RS11590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DTW94_RS11595	COG0776	regulation of translation
DTW94_RS11605	COG3973	AAA domain
DTW94_RS11605	COG3973	AAA domain
DTW94_RS11635	COG2223	nitrite transmembrane transporter activity
DTW94_RS11640	COG0583	DNA-binding transcription factor activity
DTW94_RS11690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DTW94_RS11695	COG0793	Belongs to the peptidase S41A family
DTW94_RS11700	COG2177	Part of the ABC transporter FtsEX involved in
DTW94_RS11705	COG2884	Cell division ATP-binding protein ftsE
DTW94_RS11720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DTW94_RS11725	COG0515	serine threonine protein kinase
DTW94_RS11730	COG0515	serine threonine protein kinase
DTW94_RS11740	COG1653	transport
DTW94_RS11745	COG1175	transmembrane transport
DTW94_RS11750	COG0395	ABC-type sugar transport system, permease component
DTW94_RS11760	COG1309	transcriptional regulator
DTW94_RS11770	COG1134	teichoic acid transport
DTW94_RS11775	COG2902	Dehydrogenase
DTW94_RS11800	COG0653	protein targeting
DTW94_RS11815	COG2197	response regulator
DTW94_RS11820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DTW94_RS11825	COG1040	competence protein
DTW94_RS11830	COG0823	Involved in the tonB-independent uptake of proteins
DTW94_RS11835	COG5002	protein histidine kinase activity
DTW94_RS11835	COG5000	phosphorelay sensor kinase activity
DTW94_RS11840	COG0745	RESPONSE REGULATOR receiver
DTW94_RS11845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DTW94_RS11865	COG0714	Associated with various cellular activities
DTW94_RS11905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DTW94_RS11915	COG1482	cell wall glycoprotein biosynthetic process
DTW94_RS11925	COG2835	tetraacyldisaccharide 4'-kinase activity
DTW94_RS11935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DTW94_RS11975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DTW94_RS11980	COG0778	Nitroreductase
DTW94_RS11980	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DTW94_RS11995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DTW94_RS12010	COG1316	TRANSCRIPTIONal
DTW94_RS12015	COG1316	TRANSCRIPTIONal
DTW94_RS12025	COG1316	TRANSCRIPTIONal
DTW94_RS12035	COG1316	TRANSCRIPTIONal
DTW94_RS12070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DTW94_RS12110	COG2205	protein histidine kinase activity
DTW94_RS12115	COG0745	RESPONSE REGULATOR receiver
DTW94_RS12120	COG3104	oligopeptide transport
DTW94_RS12150	COG1366	Belongs to the anti-sigma-factor antagonist family
DTW94_RS12155	COG1191	sigma factor activity
DTW94_RS12160	COG1228	amidohydrolase
DTW94_RS12170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DTW94_RS12175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DTW94_RS12180	COG0531	amino acid
DTW94_RS12225	COG2755	lipolytic protein G-D-S-L family
DTW94_RS12230	COG0183	Belongs to the thiolase family
DTW94_RS12255	COG0577	efflux transmembrane transporter activity
DTW94_RS12255	COG1136	(ABC) transporter
DTW94_RS12260	COG0577	efflux transmembrane transporter activity
DTW94_RS12260	COG1136	(ABC) transporter
DTW94_RS12265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DTW94_RS12270	COG1252	NADH dehydrogenase
DTW94_RS12295	COG0148	phosphopyruvate hydratase activity
DTW94_RS12315	COG2124	cytochrome p450
DTW94_RS12455	COG1994	Peptidase M50
DTW94_RS12485	COG3629	intracellular signal transduction
DTW94_RS12485	COG3903	Transcriptional regulator
DTW94_RS12495	COG0577	efflux transmembrane transporter activity
DTW94_RS12500	COG1136	(ABC) transporter
DTW94_RS12515	COG0477	Major facilitator Superfamily
DTW94_RS12545	COG2124	cytochrome p450
DTW94_RS12580	COG4585	Histidine kinase
DTW94_RS12595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DTW94_RS12600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DTW94_RS12605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DTW94_RS12610	COG0193	aminoacyl-tRNA hydrolase activity
DTW94_RS12620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DTW94_RS12640	COG4106	trans-aconitate 2-methyltransferase activity
DTW94_RS12650	COG2197	response regulator
DTW94_RS12660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DTW94_RS12675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTW94_RS12700	COG0488	(ABC) transporter
DTW94_RS12705	COG2161	toxin-antitoxin pair type II binding
DTW94_RS12710	COG4115	mRNA cleavage
DTW94_RS12730	COG2813	Specifically methylates the guanine in position
DTW94_RS12735	COG2318	DinB family
DTW94_RS12740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DTW94_RS12745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DTW94_RS12755	COG0084	hydrolase, TatD family'
DTW94_RS12825	COG0442	prolyl-tRNA aminoacylation
DTW94_RS12875	COG1115	amino acid carrier protein
DTW94_RS12905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DTW94_RS12910	COG1122	ATPase activity
DTW94_RS12920	COG0310	cobalt ion transport
DTW94_RS12930	COG2409	Drug exporters of the RND superfamily
DTW94_RS12940	COG4946	Tricorn protease homolog
DTW94_RS12940	COG0793	Belongs to the peptidase S41A family
DTW94_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS12965	COG2072	flavoprotein involved in K transport
DTW94_RS12975	COG0708	Exodeoxyribonuclease III
DTW94_RS12985	COG2340	Cysteine-rich secretory protein family
DTW94_RS13015	COG0521	Mo-molybdopterin cofactor biosynthetic process
DTW94_RS13020	COG0315	cyclic pyranopterin monophosphate synthase activity
DTW94_RS13030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DTW94_RS13035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DTW94_RS13045	COG3263	regulation of cellular component size
DTW94_RS13060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DTW94_RS13070	COG1970	mechanosensitive ion channel activity
DTW94_RS13090	COG0437	4 iron, 4 sulfur cluster binding
DTW94_RS13095	COG0243	molybdopterin cofactor binding
DTW94_RS13115	COG0477	Major facilitator Superfamily
DTW94_RS13135	COG3384	dioxygenase
DTW94_RS13140	COG1846	Transcriptional regulator
DTW94_RS13170	COG2197	response regulator
DTW94_RS13200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DTW94_RS13205	COG0475	glutathione-regulated potassium exporter activity
DTW94_RS13230	COG0463	Glycosyl transferase, family 2
DTW94_RS13260	COG3629	intracellular signal transduction
DTW94_RS13260	COG3903	Transcriptional regulator
DTW94_RS13270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DTW94_RS13310	COG1686	Belongs to the peptidase S11 family
DTW94_RS13340	COG1397	ADP-ribosylglycohydrolase
DTW94_RS13360	COG3655	Transcriptional regulator
DTW94_RS13390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DTW94_RS13400	COG0768	penicillin binding
DTW94_RS13435	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DTW94_RS13460	COG0667	Aldo Keto reductase
DTW94_RS13465	COG1309	transcriptional regulator
DTW94_RS13570	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
DTW94_RS13580	COG0183	Belongs to the thiolase family
DTW94_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS13600	COG1309	transcriptional regulator
DTW94_RS13630	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS13645	COG1301	dicarboxylic acid transport
DTW94_RS13660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DTW94_RS13670	COG0163	prenyltransferase activity
DTW94_RS13680	COG0109	protoheme IX farnesyltransferase activity
DTW94_RS13685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DTW94_RS13695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DTW94_RS13700	COG1333	cytochrome c biogenesis protein
DTW94_RS13705	COG0785	Cytochrome C biogenesis protein
DTW94_RS13725	COG0406	alpha-ribazole phosphatase activity
DTW94_RS13730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DTW94_RS13775	COG1690	Belongs to the RtcB family
DTW94_RS13795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DTW94_RS13800	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DTW94_RS13805	COG0018	arginyl-trna synthetase
DTW94_RS13815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DTW94_RS13850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DTW94_RS13880	COG0113	porphobilinogen synthase activity
DTW94_RS13885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DTW94_RS13885	COG1648	precorrin-2 dehydrogenase activity
DTW94_RS13890	COG0181	hydroxymethylbilane synthase activity
DTW94_RS13895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DTW94_RS13900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DTW94_RS13955	COG2223	nitrite transmembrane transporter activity
DTW94_RS13960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTW94_RS13985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DTW94_RS13995	COG0842	Transport permease protein
DTW94_RS13995	COG1129	ABC transporter
DTW94_RS14005	COG4991	sh3 domain protein
DTW94_RS14015	COG0129	dihydroxy-acid dehydratase activity
DTW94_RS14025	COG1082	Xylose isomerase domain protein TIM barrel
DTW94_RS14030	COG0248	Ppx GppA phosphatase
DTW94_RS14050	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DTW94_RS14060	COG1194	a g-specific adenine glycosylase
DTW94_RS14065	COG1595	DNA-templated transcription, initiation
DTW94_RS14075	COG0745	RESPONSE REGULATOR receiver
DTW94_RS14080	COG2205	protein histidine kinase activity
DTW94_RS14085	COG0739	heme binding
DTW94_RS14130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DTW94_RS14150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DTW94_RS14160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DTW94_RS14165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DTW94_RS14185	COG2197	response regulator
DTW94_RS14200	COG0649	NAD binding
DTW94_RS14215	COG1174	glycine betaine transport
DTW94_RS14220	COG1174	glycine betaine transport
DTW94_RS14225	COG1125	glycine betaine transport
DTW94_RS14225	COG0517	IMP dehydrogenase activity
DTW94_RS14235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DTW94_RS14235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DTW94_RS14250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DTW94_RS14265	COG0302	gtp cyclohydrolase
DTW94_RS14280	COG0037	tRNA processing
DTW94_RS14290	COG2027	D-alanyl-D-alanine carboxypeptidase
DTW94_RS14295	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DTW94_RS14305	COG0586	Pfam SNARE associated Golgi protein
DTW94_RS14320	COG0655	NAD(P)H dehydrogenase (quinone) activity
DTW94_RS14325	COG0076	glutamate decarboxylase activity
DTW94_RS14345	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS14380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DTW94_RS14380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DTW94_RS14410	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DTW94_RS14420	COG1725	Transcriptional regulator
DTW94_RS14440	COG0326	Molecular chaperone. Has ATPase activity
DTW94_RS14450	COG2205	protein histidine kinase activity
DTW94_RS14470	COG0372	Belongs to the citrate synthase family
DTW94_RS14485	COG4948	Mandelate Racemase Muconate Lactonizing
DTW94_RS14490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTW94_RS14495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS14510	COG1181	Belongs to the D-alanine--D-alanine ligase family
DTW94_RS14525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DTW94_RS14530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DTW94_RS14535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DTW94_RS14535	COG1754	DNA topoisomerase type I activity
DTW94_RS14545	COG2890	protein-(glutamine-N5) methyltransferase activity
DTW94_RS14555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DTW94_RS14565	COG1366	Belongs to the anti-sigma-factor antagonist family
DTW94_RS14570	COG1111	helicase
DTW94_RS14570	COG1205	dead DEAH box helicase
DTW94_RS14630	COG0288	reversible hydration of carbon dioxide
DTW94_RS14635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTW94_RS14640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DTW94_RS14650	COG2267	carboxylic ester hydrolase activity
DTW94_RS14680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DTW94_RS14705	COG0003	Pfam Anion-transporting ATPase
DTW94_RS14720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DTW94_RS14725	COG1610	YqeY-like protein
DTW94_RS14730	COG1408	metallophosphoesterase
DTW94_RS14820	COG2755	lipolytic protein G-D-S-L family
DTW94_RS14830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DTW94_RS14850	COG1595	DNA-templated transcription, initiation
DTW94_RS14875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DTW94_RS14880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DTW94_RS14895	COG1802	Transcriptional regulator
DTW94_RS14905	COG0693	protein deglycase activity
DTW94_RS14915	COG0515	serine threonine protein kinase
DTW94_RS14915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DTW94_RS14920	COG0738	Major facilitator superfamily
DTW94_RS14930	COG3226	Transcriptional regulator
DTW94_RS14945	COG0592	DNA-directed DNA polymerase activity
DTW94_RS14955	COG0667	Aldo Keto reductase
DTW94_RS14980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS14990	COG0662	Cupin 2, conserved barrel domain protein
DTW94_RS14995	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS15050	COG0590	tRNA wobble adenosine to inosine editing
DTW94_RS15060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DTW94_RS15065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DTW94_RS15090	COG2197	response regulator
DTW94_RS15100	COG0702	epimerase
DTW94_RS15110	COG3844	kynureninase activity
DTW94_RS15125	COG0477	Major facilitator Superfamily
DTW94_RS15130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DTW94_RS15135	COG0191	fructose-bisphosphate aldolase activity
DTW94_RS15140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DTW94_RS15155	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DTW94_RS15180	COG0542	response to heat
DTW94_RS15210	COG0789	Transcriptional regulator
DTW94_RS15215	COG0484	heat shock protein binding
DTW94_RS15220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DTW94_RS15225	COG0443	Heat shock 70 kDa protein
DTW94_RS15235	COG2181	nitrate reductase activity
DTW94_RS15235	COG0247	lactate metabolic process
DTW94_RS15255	COG0717	Belongs to the dCTP deaminase family
DTW94_RS15290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DTW94_RS15340	COG0326	Molecular chaperone. Has ATPase activity
DTW94_RS15360	COG1309	transcriptional regulator
DTW94_RS15365	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS15380	COG2197	response regulator
DTW94_RS15400	COG2205	protein histidine kinase activity
DTW94_RS15405	COG0745	RESPONSE REGULATOR receiver
DTW94_RS15420	COG1376	ErfK ybiS ycfS ynhG family protein
DTW94_RS15425	COG3046	protein related to deoxyribodipyrimidine photolyase
DTW94_RS15430	COG1533	DNA photolyase activity
DTW94_RS15440	COG2130	NADP-dependent
DTW94_RS15460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DTW94_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS15540	COG0367	asparagine synthase
DTW94_RS15555	COG1902	pentaerythritol trinitrate reductase activity
DTW94_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS15600	COG0745	RESPONSE REGULATOR receiver
DTW94_RS15610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTW94_RS15620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DTW94_RS15635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DTW94_RS15635	COG0519	Catalyzes the synthesis of GMP from XMP
DTW94_RS15660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS15675	COG1695	Transcriptional regulator
DTW94_RS15685	COG0667	Aldo Keto reductase
DTW94_RS15695	COG1609	Transcriptional regulator
DTW94_RS15720	COG2124	cytochrome p450
DTW94_RS15725	COG2124	cytochrome p450
DTW94_RS15750	COG3585	molybdate ion transport
DTW94_RS15790	COG0475	glutathione-regulated potassium exporter activity
DTW94_RS15805	COG0513	Belongs to the DEAD box helicase family
DTW94_RS15810	COG1278	Cold shock
DTW94_RS15850	COG0454	-acetyltransferase
DTW94_RS15875	COG2268	Band 7 protein
DTW94_RS15910	COG0490	domain, Protein
DTW94_RS15915	COG0475	glutathione-regulated potassium exporter activity
DTW94_RS15940	COG2255	four-way junction helicase activity
DTW94_RS15950	COG0180	Tryptophanyl-tRNA synthetase
DTW94_RS15955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DTW94_RS15960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS15990	COG0431	NADPH-dependent FMN reductase
DTW94_RS16025	COG2304	oxidoreductase activity
DTW94_RS16030	COG2205	protein histidine kinase activity
DTW94_RS16035	COG0745	RESPONSE REGULATOR receiver
DTW94_RS16040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DTW94_RS16055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DTW94_RS16070	COG1741	Belongs to the pirin family
DTW94_RS16080	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS16085	COG1362	aminopeptidase activity
DTW94_RS16105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DTW94_RS16150	COG0508	dehydrogenase complex catalyzes the overall conversion of
DTW94_RS16155	COG0022	dehydrogenase e1 component
DTW94_RS16180	COG0515	serine threonine protein kinase
DTW94_RS16185	COG0515	serine threonine protein kinase
DTW94_RS16200	COG1136	(ABC) transporter
DTW94_RS16200	COG4591	ABC-type transport system involved in lipoprotein release permease component
DTW94_RS16215	COG0604	alcohol dehydrogenase
DTW94_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS16215	COG3321	synthase
DTW94_RS16220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DTW94_RS16230	COG0746	molybdenum cofactor guanylyltransferase activity
DTW94_RS16250	COG1522	sequence-specific DNA binding
DTW94_RS16255	COG1309	transcriptional regulator
DTW94_RS16280	COG3396	Phenylacetate-CoA oxygenase
DTW94_RS16285	COG3460	Phenylacetate-CoA oxygenase
DTW94_RS16290	COG3396	Phenylacetate-CoA oxygenase
DTW94_RS16295	COG2151	metal-sulfur cluster biosynthetic enzyme
DTW94_RS16300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DTW94_RS16305	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS16310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DTW94_RS16335	COG1716	ATPase activity
DTW94_RS16340	COG1716	ATPase activity
DTW94_RS16355	COG0768	penicillin binding
DTW94_RS16360	COG0515	serine threonine protein kinase
DTW94_RS16365	COG3764	Sortase (surface protein transpeptidase)
DTW94_RS16370	COG3764	Sortase (surface protein transpeptidase)
DTW94_RS16385	COG3764	Sortase (surface protein transpeptidase)
DTW94_RS16400	COG0705	Rhomboid family
DTW94_RS16430	COG0515	serine threonine protein kinase
DTW94_RS16465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DTW94_RS16475	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DTW94_RS16480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DTW94_RS16485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DTW94_RS16490	COG0592	DNA-directed DNA polymerase activity
DTW94_RS16510	COG0594	ribonuclease P activity
DTW94_RS16515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DTW94_RS16520	COG0706	membrane insertase activity
DTW94_RS16530	COG0357	Ribosomal RNA small subunit methyltransferase G
DTW94_RS16535	COG1192	Involved in chromosome partitioning
DTW94_RS16550	COG3118	belongs to the thioredoxin family
DTW94_RS16555	COG0492	ferredoxin-NADP+ reductase activity
DTW94_RS16565	COG1595	DNA-templated transcription, initiation
DTW94_RS16570	COG2815	serine threonine protein kinase
DTW94_RS16570	COG0515	serine threonine protein kinase
DTW94_RS16585	COG0617	tRNA 3'-terminal CCA addition
DTW94_RS16605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DTW94_RS16630	COG0360	Binds together with S18 to 16S ribosomal RNA
DTW94_RS16635	COG0629	single-stranded DNA binding
DTW94_RS16640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DTW94_RS16645	COG0359	binds to the 23S rRNA
DTW94_RS16650	COG0534	Mate efflux family protein
DTW94_RS16655	COG0305	Participates in initiation and elongation during chromosome replication
DTW94_RS16685	COG2814	Major facilitator Superfamily
DTW94_RS16705	COG0626	cystathionine gamma-synthase activity
DTW94_RS16710	COG1950	PFAM Membrane protein of
DTW94_RS16715	COG0662	Cupin 2, conserved barrel domain protein
DTW94_RS16740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DTW94_RS16745	COG3152	Membrane
DTW94_RS16755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DTW94_RS16760	COG1609	Transcriptional regulator
DTW94_RS16765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DTW94_RS16770	COG1271	oxidase subunit
DTW94_RS16775	COG1294	oxidase, subunit
DTW94_RS16780	COG4988	ABC transporter
DTW94_RS16790	COG0561	phosphatase activity
DTW94_RS16800	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DTW94_RS16805	COG0789	Transcriptional regulator
DTW94_RS16820	COG1131	(ABC) transporter
DTW94_RS16845	COG0561	phosphatase activity
DTW94_RS16850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DTW94_RS16855	COG0077	Prephenate dehydratase
DTW94_RS16860	COG2837	iron assimilation
DTW94_RS16865	COG2372	response to copper ion
DTW94_RS16875	COG1999	signal sequence binding
DTW94_RS16895	COG0006	proline dipeptidase activity
DTW94_RS16915	COG0653	protein targeting
DTW94_RS16930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTW94_RS16955	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS16980	COG1595	DNA-templated transcription, initiation
DTW94_RS16985	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS17070	COG0456	acetyltransferase
DTW94_RS17120	COG2186	Transcriptional regulator
DTW94_RS17170	COG0745	RESPONSE REGULATOR receiver
DTW94_RS17175	COG2205	protein histidine kinase activity
DTW94_RS17185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DTW94_RS17200	COG0477	Major facilitator Superfamily
DTW94_RS17215	COG3467	pyridoxamine 5'-phosphate
DTW94_RS17220	COG2353	YceI-like domain
DTW94_RS17230	COG1846	Transcriptional regulator
DTW94_RS17245	COG1191	sigma factor activity
DTW94_RS17250	COG1191	sigma factor activity
DTW94_RS17315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DTW94_RS17350	COG4941	Belongs to the sigma-70 factor family
DTW94_RS17370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DTW94_RS17405	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DTW94_RS17440	COG2815	serine threonine protein kinase
DTW94_RS17440	COG0515	serine threonine protein kinase
DTW94_RS17445	COG0492	ferredoxin-NADP+ reductase activity
DTW94_RS17485	COG0419	ATPase involved in DNA repair
DTW94_RS17535	COG0494	nUDIX hydrolase
DTW94_RS17580	COG0151	Belongs to the GarS family
DTW94_RS17595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DTW94_RS17610	COG2197	response regulator
DTW94_RS17625	COG1131	(ABC) transporter
DTW94_RS17645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DTW94_RS17650	COG0047	phosphoribosylformylglycinamidine synthase activity
DTW94_RS17655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DTW94_RS17665	COG1196	nuclear chromosome segregation
DTW94_RS17665	COG0739	heme binding
DTW94_RS17665	COG0741	lytic transglycosylase activity
DTW94_RS17670	COG2318	DinB family
DTW94_RS17685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DTW94_RS17720	COG1643	Atp-dependent helicase
DTW94_RS17730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DTW94_RS17730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DTW94_RS17735	COG0785	Cytochrome C biogenesis protein
DTW94_RS17770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DTW94_RS17780	COG0513	Belongs to the DEAD box helicase family
DTW94_RS17790	COG1366	Belongs to the anti-sigma-factor antagonist family
DTW94_RS17800	COG0596	Alpha beta hydrolase
DTW94_RS17830	COG1191	sigma factor activity
DTW94_RS17855	COG0789	Transcriptional regulator
DTW94_RS17865	COG0741	lytic transglycosylase activity
DTW94_RS17865	COG0739	heme binding
DTW94_RS17865	COG1196	nuclear chromosome segregation
DTW94_RS17875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DTW94_RS17880	COG0579	oxidoreductase
DTW94_RS17905	COG1252	NADH dehydrogenase
DTW94_RS17920	COG1846	Transcriptional regulator
DTW94_RS17995	COG0741	lytic transglycosylase activity
DTW94_RS17995	COG1196	nuclear chromosome segregation
DTW94_RS17995	COG0739	heme binding
DTW94_RS18000	COG0671	phosphoesterase, PA-phosphatase related
DTW94_RS18020	COG1937	Protein conserved in bacteria
DTW94_RS18030	COG0306	phosphate transporter
DTW94_RS18050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DTW94_RS18055	COG0494	nUDIX hydrolase
DTW94_RS18055	COG0406	alpha-ribazole phosphatase activity
DTW94_RS18075	COG1116	anion transmembrane transporter activity
DTW94_RS18080	COG1725	Transcriptional regulator
DTW94_RS18090	COG0456	acetyltransferase
DTW94_RS18110	COG0737	Belongs to the 5'-nucleotidase family
DTW94_RS18175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTW94_RS18180	COG1609	Transcriptional regulator
DTW94_RS18185	COG0745	RESPONSE REGULATOR receiver
DTW94_RS18210	COG2897	thiosulfate sulfurtransferase activity
DTW94_RS18250	COG3485	protocatechuate 3,4-dioxygenase
DTW94_RS18255	COG0735	belongs to the Fur family
DTW94_RS18265	COG1490	D-aminoacyl-tRNA deacylase activity
DTW94_RS18280	COG4552	Acetyltransferase involved in intracellular survival and related
DTW94_RS18340	COG0475	glutathione-regulated potassium exporter activity
DTW94_RS18370	COG4770	biotin carboxylase activity
DTW94_RS18395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS18425	COG0736	holo-[acyl-carrier-protein] synthase activity
DTW94_RS18430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTW94_RS18455	COG2318	DinB family
DTW94_RS18465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS18505	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS18540	COG0588	phosphoglycerate mutase activity
DTW94_RS18555	COG5002	protein histidine kinase activity
DTW94_RS18575	COG1329	Transcriptional regulator
DTW94_RS18580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DTW94_RS18585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DTW94_RS18595	COG0215	cysteine-tRNA ligase activity
DTW94_RS18610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DTW94_RS18620	COG3842	ATPase activity
DTW94_RS18645	COG0745	RESPONSE REGULATOR receiver
DTW94_RS18690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTW94_RS18730	COG2197	response regulator
DTW94_RS18735	COG4585	Histidine kinase
DTW94_RS18745	COG0666	response to abiotic stimulus
DTW94_RS18770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DTW94_RS18800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DTW94_RS18820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTW94_RS18820	COG1877	trehalose-phosphatase activity
DTW94_RS18825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DTW94_RS18830	COG0463	Glycosyl transferase, family 2
DTW94_RS18880	COG1132	(ABC) transporter
DTW94_RS18895	COG1595	DNA-templated transcription, initiation
DTW94_RS18930	COG0395	ABC-type sugar transport system, permease component
DTW94_RS18935	COG1175	transmembrane transport
DTW94_RS18970	COG4251	negative regulation of phosphorylation
DTW94_RS18975	COG2197	response regulator
DTW94_RS19000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DTW94_RS19000	COG1263	PTS System
DTW94_RS19005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DTW94_RS19010	COG1737	Transcriptional regulator
DTW94_RS19045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DTW94_RS19050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DTW94_RS19055	COG1984	allophanate hydrolase subunit 2
DTW94_RS19070	COG3142	Participates in the control of copper homeostasis
DTW94_RS19075	COG3973	AAA domain
DTW94_RS19095	COG1061	Type III restriction enzyme res subunit
DTW94_RS19100	COG1846	Transcriptional regulator
DTW94_RS19125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DTW94_RS19130	COG1120	ATPase activity
DTW94_RS19135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS19140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS19160	COG1278	Cold shock
DTW94_RS19165	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DTW94_RS19170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DTW94_RS19180	COG2814	Major facilitator Superfamily
DTW94_RS19200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DTW94_RS19210	COG2252	PERMEase
DTW94_RS19245	COG0667	Aldo Keto reductase
DTW94_RS19250	COG2267	carboxylic ester hydrolase activity
DTW94_RS19260	COG0515	serine threonine protein kinase
DTW94_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS19270	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS19275	COG0583	DNA-binding transcription factor activity
DTW94_RS19355	COG1051	belongs to the nudix hydrolase family
DTW94_RS19375	COG1309	transcriptional regulator
DTW94_RS19385	COG0697	spore germination
DTW94_RS19445	COG1335	isochorismatase
DTW94_RS19480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DTW94_RS19510	COG2205	protein histidine kinase activity
DTW94_RS19515	COG0247	lactate metabolic process
DTW94_RS19515	COG0277	FAD linked oxidase domain protein
DTW94_RS19520	COG3896	Chloramphenicol phosphotransferase-like protein
DTW94_RS19535	COG5006	permease, DMT superfamily
DTW94_RS19540	COG0494	nUDIX hydrolase
DTW94_RS19545	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
DTW94_RS19565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTW94_RS19580	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS19585	COG1024	Enoyl-CoA hydratase
DTW94_RS19660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DTW94_RS19675	COG2124	cytochrome p450
DTW94_RS19700	COG0259	pyridoxamine-phosphate oxidase activity
DTW94_RS19715	COG2205	protein histidine kinase activity
DTW94_RS19720	COG4821	SIS domain
DTW94_RS19730	COG2267	carboxylic ester hydrolase activity
DTW94_RS19760	COG0477	Major facilitator Superfamily
DTW94_RS19770	COG1595	DNA-templated transcription, initiation
DTW94_RS19835	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS19845	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS19850	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS19875	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS19950	COG1024	Enoyl-CoA hydratase
DTW94_RS19975	COG2072	flavoprotein involved in K transport
DTW94_RS19980	COG4592	Periplasmic binding protein
DTW94_RS19985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS19990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS20020	COG0501	Belongs to the peptidase M48B family
DTW94_RS20025	COG0259	pyridoxamine-phosphate oxidase activity
DTW94_RS20035	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS20045	COG1309	transcriptional regulator
DTW94_RS20070	COG1024	Enoyl-CoA hydratase
DTW94_RS20110	COG1278	Cold shock
DTW94_RS20115	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DTW94_RS20125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DTW94_RS20135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTW94_RS20140	COG4521	taurine ABC transporter
DTW94_RS20150	COG2175	clavaminate synthase activity
DTW94_RS20155	COG2226	methyltransferase
DTW94_RS20225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20235	COG0649	NAD binding
DTW94_RS20245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DTW94_RS20250	COG1034	ATP synthesis coupled electron transport
DTW94_RS20255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DTW94_RS20260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20265	COG0839	Belongs to the complex I subunit 6 family
DTW94_RS20270	COG0713	ATP synthesis coupled electron transport
DTW94_RS20275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DTW94_RS20285	COG1007	ATP synthesis coupled electron transport
DTW94_RS20290	COG0514	ATP-dependent DNA helicase (RecQ)
DTW94_RS20315	COG3104	oligopeptide transport
DTW94_RS20320	COG0142	geranyltranstransferase activity
DTW94_RS20330	COG1131	(ABC) transporter
DTW94_RS20355	COG0561	phosphatase activity
DTW94_RS20395	COG0702	epimerase
DTW94_RS20400	COG1733	regulation of RNA biosynthetic process
DTW94_RS20405	COG1013	pyruvate-flavodoxin oxidoreductase activity
DTW94_RS20410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DTW94_RS20410	COG0674	pyruvate-flavodoxin oxidoreductase activity
DTW94_RS20430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20435	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DTW94_RS20450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DTW94_RS20455	COG0839	Belongs to the complex I subunit 6 family
DTW94_RS20460	COG0713	ATP synthesis coupled electron transport
DTW94_RS20465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DTW94_RS20475	COG1007	ATP synthesis coupled electron transport
DTW94_RS20480	COG1970	mechanosensitive ion channel activity
DTW94_RS20485	COG0501	Belongs to the peptidase M48B family
DTW94_RS20490	COG3304	Inner membrane component domain
DTW94_RS20495	COG2261	transglycosylase associated protein
DTW94_RS20505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DTW94_RS20510	COG1666	GTP binding
DTW94_RS20540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DTW94_RS20545	COG2030	dehydratase
DTW94_RS20555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DTW94_RS20570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DTW94_RS20575	COG0436	Aminotransferase
DTW94_RS20595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DTW94_RS20600	COG0081	regulation of translation
DTW94_RS20605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DTW94_RS20610	COG0222	ribosome binding
DTW94_RS20620	COG0085	RNA polymerase activity
DTW94_RS20625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DTW94_RS20730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DTW94_RS20735	COG0049	tRNA binding
DTW94_RS20740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DTW94_RS20745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DTW94_RS20770	COG0051	transcription antitermination factor activity, RNA binding
DTW94_RS20775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DTW94_RS20780	COG0088	Forms part of the polypeptide exit tunnel
DTW94_RS20785	COG0089	rRNA binding
DTW94_RS20790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DTW94_RS20795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DTW94_RS20800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DTW94_RS20805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DTW94_RS20810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DTW94_RS20815	COG0255	Belongs to the universal ribosomal protein uL29 family
DTW94_RS20820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DTW94_RS20825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DTW94_RS20830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DTW94_RS20835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DTW94_RS20840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DTW94_RS20850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DTW94_RS20855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DTW94_RS20860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DTW94_RS20865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DTW94_RS20870	COG1841	ribosomal large subunit assembly
DTW94_RS20875	COG0200	Binds to the 23S rRNA
DTW94_RS20885	COG0563	adenylate kinase activity
DTW94_RS20895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DTW94_RS20900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DTW94_RS20905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DTW94_RS20910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DTW94_RS20915	COG0202	RNA polymerase activity
DTW94_RS20920	COG0203	ribosomal protein L17
DTW94_RS20925	COG0101	tRNA pseudouridine synthase activity
DTW94_RS20950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DTW94_RS20955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DTW94_RS20960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DTW94_RS20970	COG1072	(Pantothenic acid kinase))
DTW94_RS20985	COG4566	intracellular signal transduction
DTW94_RS21000	COG3795	YCII-related domain
DTW94_RS21005	COG4941	Belongs to the sigma-70 factor family
DTW94_RS21030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DTW94_RS21035	COG0736	holo-[acyl-carrier-protein] synthase activity
DTW94_RS21045	COG3189	MarR family transcriptional regulator
DTW94_RS21050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DTW94_RS21060	COG0802	atpase or kinase
DTW94_RS21085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DTW94_RS21120	COG0726	polysaccharide deacetylase
DTW94_RS21130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DTW94_RS21140	COG4221	oxidoreductase activity
DTW94_RS21150	COG0583	DNA-binding transcription factor activity
DTW94_RS21165	COG1595	DNA-templated transcription, initiation
DTW94_RS21175	COG0516	GMP reductase activity
DTW94_RS21190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DTW94_RS21205	COG0515	serine threonine protein kinase
DTW94_RS21210	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS21230	COG0519	Catalyzes the synthesis of GMP from XMP
DTW94_RS21230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DTW94_RS21270	COG2197	response regulator
DTW94_RS21305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS21305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS21325	COG0714	Associated with various cellular activities
DTW94_RS21330	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DTW94_RS21335	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DTW94_RS21340	COG0045	succinate-CoA ligase (ADP-forming) activity
DTW94_RS21370	COG0138	bifunctional purine biosynthesis protein purh
DTW94_RS21385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DTW94_RS21400	COG0039	L-malate dehydrogenase activity
DTW94_RS21405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTW94_RS21410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTW94_RS21420	COG0754	glutathionylspermidine amidase activity
DTW94_RS21425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DTW94_RS21430	COG0180	Tryptophanyl-tRNA synthetase
DTW94_RS21450	COG1295	ribonuclease BN
DTW94_RS21455	COG1686	Belongs to the peptidase S11 family
DTW94_RS21465	COG1408	metallophosphoesterase
DTW94_RS21495	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DTW94_RS21500	COG1053	succinate dehydrogenase
DTW94_RS21510	COG2009	succinate dehydrogenase
DTW94_RS21570	COG1595	DNA-templated transcription, initiation
DTW94_RS21600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DTW94_RS21610	COG1216	Glycosyl transferase, family 2
DTW94_RS21630	COG1083	cytidylyl-transferase
DTW94_RS21635	COG2089	acid synthase
DTW94_RS21645	COG1473	amidohydrolase
DTW94_RS21645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DTW94_RS21650	COG1744	ABC transporter substrate-binding protein PnrA-like
DTW94_RS21655	COG3845	ABC transporter
DTW94_RS21660	COG4603	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS21665	COG1079	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS21685	COG1404	Belongs to the peptidase S8 family
DTW94_RS21705	COG2814	Major facilitator Superfamily
DTW94_RS21710	COG0583	DNA-binding transcription factor activity
DTW94_RS21725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DTW94_RS21750	COG2205	protein histidine kinase activity
DTW94_RS21755	COG0745	RESPONSE REGULATOR receiver
DTW94_RS21760	COG1595	DNA-templated transcription, initiation
DTW94_RS21790	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS21795	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS21810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DTW94_RS21830	COG1349	DNA-binding transcription factor activity
DTW94_RS21840	COG4770	biotin carboxylase activity
DTW94_RS21850	COG0424	maF-like protein
DTW94_RS21860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTW94_RS21875	COG1024	Enoyl-CoA hydratase
DTW94_RS21905	COG1376	ErfK ybiS ycfS ynhG family protein
DTW94_RS21920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DTW94_RS21925	COG1396	sequence-specific DNA binding
DTW94_RS21940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DTW94_RS21960	COG1595	DNA-templated transcription, initiation
DTW94_RS21970	COG2202	Pas domain
DTW94_RS21970	COG2205	protein histidine kinase activity
DTW94_RS21980	COG2172	sigma factor antagonist activity
DTW94_RS21985	COG1366	Belongs to the anti-sigma-factor antagonist family
DTW94_RS21990	COG1366	Belongs to the anti-sigma-factor antagonist family
DTW94_RS21995	COG2255	four-way junction helicase activity
DTW94_RS22000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DTW94_RS22015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DTW94_RS22025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DTW94_RS22070	COG0492	ferredoxin-NADP+ reductase activity
DTW94_RS22075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DTW94_RS22085	COG0798	PFAM Bile acid sodium symporter
DTW94_RS22090	COG2072	flavoprotein involved in K transport
DTW94_RS22105	COG0492	ferredoxin-NADP+ reductase activity
DTW94_RS22110	COG0640	Transcriptional regulator
DTW94_RS22140	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DTW94_RS22215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DTW94_RS22230	COG1414	Transcriptional regulator
DTW94_RS22235	COG0251	oxidation-reduction process
DTW94_RS22240	COG2610	gluconate transmembrane transporter activity
DTW94_RS22265	COG2894	cell division
DTW94_RS22295	COG3920	Histidine kinase
DTW94_RS22300	COG2197	response regulator
DTW94_RS22320	COG2885	chlorophyll binding
DTW94_RS22370	COG0667	Aldo Keto reductase
DTW94_RS22375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DTW94_RS22385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DTW94_RS22400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTW94_RS22405	COG0450	alkyl hydroperoxide reductase
DTW94_RS22420	COG1136	(ABC) transporter
DTW94_RS22440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DTW94_RS22440	COG4499	WXG100 protein secretion system (Wss), protein YukC
DTW94_RS22455	COG0114	fumarate hydratase activity
DTW94_RS22465	COG1362	aminopeptidase activity
DTW94_RS22470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DTW94_RS22470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DTW94_RS22495	COG0778	Nitroreductase
DTW94_RS22500	COG1722	exodeoxyribonuclease VII activity
DTW94_RS22505	COG1570	exodeoxyribonuclease VII activity
DTW94_RS22515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DTW94_RS22530	COG0012	GTP binding
DTW94_RS22560	COG0789	Transcriptional regulator
DTW94_RS22600	COG1842	Phage shock protein A
DTW94_RS22610	COG0463	Glycosyl transferase, family 2
DTW94_RS22620	COG4941	Belongs to the sigma-70 factor family
DTW94_RS22625	COG3795	YCII-related domain
DTW94_RS22660	COG0148	phosphopyruvate hydratase activity
DTW94_RS22695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DTW94_RS22700	COG2226	methyltransferase
DTW94_RS22710	COG1217	gtp-binding protein TYPA
DTW94_RS22720	COG0747	negative chemotaxis
DTW94_RS22725	COG0601	transmembrane transport
DTW94_RS22730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS22740	COG4608	Belongs to the ABC transporter superfamily
DTW94_RS22745	COG4166	transmembrane transport
DTW94_RS22750	COG0601	transmembrane transport
DTW94_RS22755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS22765	COG4608	Belongs to the ABC transporter superfamily
DTW94_RS22770	COG2197	response regulator
DTW94_RS22785	COG1136	(ABC) transporter
DTW94_RS22785	COG0577	efflux transmembrane transporter activity
DTW94_RS22815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DTW94_RS22850	COG0110	maltose O-acetyltransferase activity
DTW94_RS22860	COG0515	serine threonine protein kinase
DTW94_RS22870	COG1132	(ABC) transporter
DTW94_RS22875	COG1132	(ABC) transporter
DTW94_RS22880	COG2197	response regulator
DTW94_RS22885	COG2912	Transglutaminase-like superfamily
DTW94_RS22915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DTW94_RS22920	COG1611	Belongs to the LOG family
DTW94_RS22925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DTW94_RS22935	COG0519	Catalyzes the synthesis of GMP from XMP
DTW94_RS22940	COG1024	Enoyl-CoA hydratase
DTW94_RS22955	COG1595	DNA-templated transcription, initiation
DTW94_RS22965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DTW94_RS22970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DTW94_RS23005	COG0598	Magnesium transport protein CorA
DTW94_RS23025	COG2095	MarC family integral membrane protein
DTW94_RS23030	COG1432	Conserved Protein
DTW94_RS23045	COG0513	Belongs to the DEAD box helicase family
DTW94_RS23085	COG0747	negative chemotaxis
DTW94_RS23090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS23095	COG0601	transmembrane transport
DTW94_RS23100	COG4172	Belongs to the ABC transporter superfamily
DTW94_RS23155	COG0210	DNA helicase
DTW94_RS23200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DTW94_RS23250	COG3480	Lon protease (S16) C-terminal proteolytic domain
DTW94_RS23260	COG1615	UPF0182 protein
DTW94_RS23285	COG0753	catalase activity
DTW94_RS23295	COG0483	inositol monophosphate 1-phosphatase activity
DTW94_RS23305	COG2076	Multidrug Resistance protein
DTW94_RS23310	COG1162	GTPase activity
DTW94_RS23315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DTW94_RS23325	COG2135	peptidase activity
DTW94_RS23335	COG1595	DNA-templated transcription, initiation
DTW94_RS23340	COG5662	AntiSigma factor
DTW94_RS23350	COG0242	peptide deformylase activity
DTW94_RS23455	COG1966	Carbon starvation protein
DTW94_RS23465	COG2182	Extracellular solute-binding protein
DTW94_RS23470	COG1175	transmembrane transport
DTW94_RS23475	COG0395	ABC-type sugar transport system, permease component
DTW94_RS23480	COG1472	Belongs to the glycosyl hydrolase 3 family
DTW94_RS23485	COG0363	glucosamine-6-phosphate deaminase activity
DTW94_RS23490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DTW94_RS23505	COG1597	lipid kinase activity
DTW94_RS23520	COG2172	sigma factor antagonist activity
DTW94_RS23575	COG1959	2 iron, 2 sulfur cluster binding
DTW94_RS23580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DTW94_RS23585	COG0142	geranyltranstransferase activity
DTW94_RS23665	COG4106	trans-aconitate 2-methyltransferase activity
DTW94_RS23670	COG1126	abc transporter atp-binding protein
DTW94_RS23675	COG0765	amino acid transport
DTW94_RS23680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS23690	COG0281	malic enzyme
DTW94_RS23695	COG0604	alcohol dehydrogenase
DTW94_RS23715	COG0542	response to heat
DTW94_RS23740	COG0567	Dehydrogenase, E1 component
DTW94_RS23740	COG0508	dehydrogenase complex catalyzes the overall conversion of
DTW94_RS23750	COG2205	protein histidine kinase activity
DTW94_RS23755	COG0745	RESPONSE REGULATOR receiver
DTW94_RS23775	COG1131	(ABC) transporter
DTW94_RS23785	COG1595	DNA-templated transcription, initiation
DTW94_RS23790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DTW94_RS23795	COG0726	polysaccharide deacetylase
DTW94_RS23870	COG0791	NLP P60 protein
DTW94_RS23870	COG3883	PFAM NLP P60 protein
DTW94_RS23885	COG1309	transcriptional regulator
DTW94_RS23915	COG0768	penicillin binding
DTW94_RS23930	COG2205	protein histidine kinase activity
DTW94_RS23950	COG1793	dna ligase
DTW94_RS23950	COG3285	dna ligase
DTW94_RS23955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DTW94_RS24050	COG0018	arginyl-trna synthetase
DTW94_RS24055	COG0019	diaminopimelate decarboxylase activity
DTW94_RS24060	COG0460	homoserine dehydrogenase
DTW94_RS24065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DTW94_RS24070	COG0083	homoserine kinase activity
DTW94_RS24080	COG1316	TRANSCRIPTIONal
DTW94_RS24085	COG0254	rRNA binding
DTW94_RS24090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DTW94_RS24095	COG2890	protein-(glutamine-N5) methyltransferase activity
DTW94_RS24105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DTW94_RS24110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DTW94_RS24115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DTW94_RS24130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DTW94_RS24135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DTW94_RS24140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DTW94_RS24145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DTW94_RS24150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DTW94_RS24155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DTW94_RS24160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DTW94_RS24175	COG2197	response regulator
DTW94_RS24180	COG3850	Histidine kinase
DTW94_RS24200	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS24215	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DTW94_RS24270	COG0183	Belongs to the thiolase family
DTW94_RS24285	COG4104	PAAR repeat-containing protein
DTW94_RS24285	COG3209	COG3209 Rhs family protein
DTW94_RS24305	COG0745	RESPONSE REGULATOR receiver
DTW94_RS24310	COG5002	protein histidine kinase activity
DTW94_RS24385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS24385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS24390	COG1597	lipid kinase activity
DTW94_RS24430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DTW94_RS24435	COG0857	belongs to the CobB CobQ family
DTW94_RS24435	COG0280	phosphate acetyltransferase
DTW94_RS24440	COG0205	6-phosphofructokinase activity
DTW94_RS24450	COG4565	transcriptional regulatory protein
DTW94_RS24455	COG3290	protein histidine kinase activity
DTW94_RS24460	COG1301	dicarboxylic acid transport
DTW94_RS24465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DTW94_RS24470	COG3281	Trehalose synthase
DTW94_RS24475	COG0366	Alpha amylase catalytic
DTW94_RS24480	COG0366	Alpha amylase catalytic
DTW94_RS24485	COG0058	SHG alpha-glucan phosphorylase activity
DTW94_RS24510	COG1132	(ABC) transporter
DTW94_RS24515	COG1132	(ABC) transporter
DTW94_RS24535	COG2197	response regulator
DTW94_RS24555	COG1024	Enoyl-CoA hydratase
DTW94_RS24600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DTW94_RS24605	COG0142	geranyltranstransferase activity
DTW94_RS24610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DTW94_RS24615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DTW94_RS24655	COG0477	Major facilitator Superfamily
DTW94_RS24665	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS24780	COG0823	Involved in the tonB-independent uptake of proteins
DTW94_RS24790	COG1222	aaa ATPase
DTW94_RS24815	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS24830	COG2235	arginine
DTW94_RS24900	COG1760	l-serine dehydratase
DTW94_RS24905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DTW94_RS24910	COG0509	glycine decarboxylation via glycine cleavage system
DTW94_RS24915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DTW94_RS24935	COG4166	transmembrane transport
DTW94_RS24940	COG0601	transmembrane transport
DTW94_RS24945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS24955	COG4608	Belongs to the ABC transporter superfamily
DTW94_RS24960	COG2860	membrane
DTW94_RS24990	COG0482	sulfurtransferase activity
DTW94_RS25010	COG4221	oxidoreductase activity
DTW94_RS25025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DTW94_RS25035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DTW94_RS25040	COG0154	amidase activity
DTW94_RS25050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DTW94_RS25055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DTW94_RS25065	COG2409	Drug exporters of the RND superfamily
DTW94_RS25080	COG2133	pyrroloquinoline quinone binding
DTW94_RS25085	COG0667	Aldo Keto reductase
DTW94_RS25105	COG0440	acetolactate synthase activity
DTW94_RS25110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DTW94_RS25115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTW94_RS25140	COG2508	Transcriptional regulator
DTW94_RS25145	COG0506	proline dehydrogenase activity
DTW94_RS25150	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS25165	COG2130	NADP-dependent
DTW94_RS25175	COG0473	3-isopropylmalate dehydrogenase activity
DTW94_RS25180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DTW94_RS25190	COG2957	Belongs to the agmatine deiminase family
DTW94_RS25205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DTW94_RS25220	COG4608	Belongs to the ABC transporter superfamily
DTW94_RS25225	COG0601	transmembrane transport
DTW94_RS25230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS25235	COG0444	Belongs to the ABC transporter superfamily
DTW94_RS25250	COG1472	Belongs to the glycosyl hydrolase 3 family
DTW94_RS25270	COG3708	Transcriptional regulator
DTW94_RS25270	COG2207	Transcriptional regulator
DTW94_RS25290	COG0492	ferredoxin-NADP+ reductase activity
DTW94_RS25305	COG1733	regulation of RNA biosynthetic process
DTW94_RS25340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS25345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS25350	COG1120	ATPase activity
DTW94_RS25355	COG4607	ABC-type enterochelin transport system periplasmic component
DTW94_RS25380	COG0366	Alpha amylase catalytic
DTW94_RS25380	COG1470	cell adhesion involved in biofilm formation
DTW94_RS25385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DTW94_RS25405	COG2018	Roadblock/LC7 domain
DTW94_RS25425	COG2018	Roadblock/LC7 domain
DTW94_RS25430	COG5002	protein histidine kinase activity
DTW94_RS25440	COG0179	Fumarylacetoacetate (FAA) hydrolase
DTW94_RS25445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DTW94_RS25480	COG1414	Transcriptional regulator
DTW94_RS25485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DTW94_RS25490	COG0066	3-isopropylmalate dehydratase activity
DTW94_RS25500	COG0776	regulation of translation
DTW94_RS25510	COG1920	GTP binding
DTW94_RS25520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DTW94_RS25525	COG1181	Belongs to the D-alanine--D-alanine ligase family
DTW94_RS25540	COG0351	phosphomethylpyrimidine kinase
DTW94_RS25545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DTW94_RS25550	COG1461	Dihydroxyacetone kinase
DTW94_RS25555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DTW94_RS25560	COG0742	ribosomal rna small subunit methyltransferase
DTW94_RS25565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DTW94_RS25580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DTW94_RS25585	COG0571	ribonuclease III activity
DTW94_RS25590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DTW94_RS25595	COG1733	regulation of RNA biosynthetic process
DTW94_RS25600	COG2340	Cysteine-rich secretory protein family
DTW94_RS25605	COG1254	Belongs to the acylphosphatase family
DTW94_RS25620	COG1196	nuclear chromosome segregation
DTW94_RS25625	COG0477	Major facilitator Superfamily
DTW94_RS25660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DTW94_RS25680	COG0228	four-way junction DNA binding
DTW94_RS25685	COG1837	Belongs to the UPF0109 family
DTW94_RS25690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DTW94_RS25695	COG0336	Belongs to the RNA methyltransferase TrmD family
DTW94_RS25700	COG0335	large ribosomal subunit rRNA binding
DTW94_RS25715	COG0681	Belongs to the peptidase S26 family
DTW94_RS25720	COG0681	Belongs to the peptidase S26 family
DTW94_RS25735	COG0792	nuclease activity
DTW94_RS25750	COG1191	sigma factor activity
DTW94_RS25765	COG0052	Belongs to the universal ribosomal protein uS2 family
DTW94_RS25770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DTW94_RS25775	COG0528	UMP kinase activity
DTW94_RS25780	COG0233	cytoplasmic translational termination
DTW94_RS25790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DTW94_RS25805	COG3842	ATPase activity
DTW94_RS25820	COG1136	(ABC) transporter
DTW94_RS25825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DTW94_RS25835	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS25860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DTW94_RS25880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DTW94_RS25885	COG3842	ATPase activity
DTW94_RS25890	COG1176	ABC-type spermidine putrescine transport system, permease component I
DTW94_RS25895	COG1177	transmembrane transport
DTW94_RS25900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTW94_RS25930	COG2508	Transcriptional regulator
DTW94_RS25935	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS25945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DTW94_RS25950	COG0750	zinc metalloprotease
DTW94_RS25955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DTW94_RS25970	COG0442	prolyl-tRNA aminoacylation
DTW94_RS25990	COG0779	Required for maturation of 30S ribosomal subunits
DTW94_RS26005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DTW94_RS26015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DTW94_RS26020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DTW94_RS26070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS26075	COG0601	transmembrane transport
DTW94_RS26080	COG0747	negative chemotaxis
DTW94_RS26085	COG0455	bacterial-type flagellum organization
DTW94_RS26105	COG3266	domain, Protein
DTW94_RS26110	COG1404	Belongs to the peptidase S8 family
DTW94_RS26125	COG1404	Belongs to the peptidase S8 family
DTW94_RS26140	COG1674	ftsk spoiiie
DTW94_RS26150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DTW94_RS26155	COG1185	polyribonucleotide nucleotidyltransferase activity
DTW94_RS26160	COG0612	Peptidase, M16
DTW94_RS26165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DTW94_RS26185	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DTW94_RS26190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DTW94_RS26195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DTW94_RS26225	COG2208	phosphoserine phosphatase activity
DTW94_RS26225	COG2770	Histidine kinase
DTW94_RS26240	COG1674	ftsk spoiiie
DTW94_RS26250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DTW94_RS26260	COG1058	Belongs to the CinA family
DTW94_RS26260	COG1546	Belongs to the CinA family
DTW94_RS26265	COG1396	sequence-specific DNA binding
DTW94_RS26270	COG0783	Belongs to the Dps family
DTW94_RS26285	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS26290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DTW94_RS26295	COG1201	RNA secondary structure unwinding
DTW94_RS26300	COG2207	Transcriptional regulator
DTW94_RS26300	COG1917	Cupin 2, conserved barrel domain protein
DTW94_RS26335	COG1271	oxidase subunit
DTW94_RS26340	COG2197	response regulator
DTW94_RS26355	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DTW94_RS26355	COG1672	PFAM Archaeal ATPase
DTW94_RS26365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DTW94_RS26395	COG0765	amino acid transport
DTW94_RS26400	COG0765	amino acid transport
DTW94_RS26405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS26410	COG1126	abc transporter atp-binding protein
DTW94_RS26415	COG0745	RESPONSE REGULATOR receiver
DTW94_RS26420	COG2205	protein histidine kinase activity
DTW94_RS26425	COG2358	TRAP transporter, solute receptor (TAXI family
DTW94_RS26430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DTW94_RS26445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DTW94_RS26455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DTW94_RS26460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DTW94_RS26470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DTW94_RS26510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DTW94_RS26515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DTW94_RS26520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DTW94_RS26555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DTW94_RS26570	COG0514	ATP-dependent DNA helicase (RecQ)
DTW94_RS26585	COG2814	Major facilitator Superfamily
DTW94_RS26600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DTW94_RS26605	COG0574	Belongs to the PEP-utilizing enzyme family
DTW94_RS26605	COG3848	Pyruvate phosphate dikinase
DTW94_RS26610	COG1309	transcriptional regulator
DTW94_RS26625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DTW94_RS26630	COG2186	Transcriptional regulator
DTW94_RS26635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DTW94_RS26660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTW94_RS26665	COG4565	transcriptional regulatory protein
DTW94_RS26670	COG3290	protein histidine kinase activity
DTW94_RS26685	COG0372	Belongs to the citrate synthase family
DTW94_RS26695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DTW94_RS26700	COG0612	Peptidase, M16
DTW94_RS26715	COG1802	Transcriptional regulator
DTW94_RS26720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DTW94_RS26725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DTW94_RS26725	COG0045	succinate-CoA ligase (ADP-forming) activity
DTW94_RS26725	COG1042	CoA-binding domain protein
DTW94_RS26740	COG1435	thymidine kinase activity
DTW94_RS26775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DTW94_RS26780	COG0483	inositol monophosphate 1-phosphatase activity
DTW94_RS26790	COG0745	RESPONSE REGULATOR receiver
DTW94_RS26795	COG2205	protein histidine kinase activity
DTW94_RS26820	COG0756	dUTP diphosphatase activity
DTW94_RS26855	COG0569	domain protein
DTW94_RS26860	COG0531	amino acid
DTW94_RS26865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DTW94_RS26925	COG2815	serine threonine protein kinase
DTW94_RS26925	COG0515	serine threonine protein kinase
DTW94_RS26945	COG2366	antibiotic biosynthetic process
DTW94_RS26965	COG3903	Transcriptional regulator
DTW94_RS26965	COG3629	intracellular signal transduction
DTW94_RS26970	COG4585	Histidine kinase
DTW94_RS26990	COG0596	Alpha beta hydrolase
DTW94_RS27015	COG0464	growth
DTW94_RS27025	COG1674	ftsk spoiiie
DTW94_RS27090	COG2192	nodulation
DTW94_RS27115	COG0505	Belongs to the CarA family
DTW94_RS27120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DTW94_RS27125	COG1280	lysine exporter protein (LysE YggA)
DTW94_RS27130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DTW94_RS27140	COG3291	Pkd domain containing protein
DTW94_RS27145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DTW94_RS27165	COG3938	Belongs to the proline racemase family
DTW94_RS27170	COG1802	Transcriptional regulator
DTW94_RS27200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS27205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS27220	COG0586	Pfam SNARE associated Golgi protein
DTW94_RS27225	COG1349	DNA-binding transcription factor activity
DTW94_RS27230	COG1799	cell septum assembly
DTW94_RS27250	COG2040	homocysteine
DTW94_RS27310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DTW94_RS27320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DTW94_RS27325	COG0531	amino acid
DTW94_RS27335	COG1024	Enoyl-CoA hydratase
DTW94_RS27365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DTW94_RS27365	COG2111	Na H antiporter
DTW94_RS27370	COG1006	Multisubunit Na H antiporter MnhC subunit
DTW94_RS27375	COG0651	ATP synthesis coupled electron transport
DTW94_RS27390	COG1320	monovalent cation:proton antiporter activity
DTW94_RS27405	COG0297	glycogen (starch) synthase activity
DTW94_RS27410	COG0489	protein tyrosine kinase activity
DTW94_RS27445	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DTW94_RS27450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DTW94_RS27455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DTW94_RS27490	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS27520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DTW94_RS27525	COG2267	carboxylic ester hydrolase activity
DTW94_RS27535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DTW94_RS27545	COG0406	alpha-ribazole phosphatase activity
DTW94_RS27555	COG1653	transport
DTW94_RS27560	COG1175	transmembrane transport
DTW94_RS27565	COG0395	ABC-type sugar transport system, permease component
DTW94_RS27570	COG1940	carbohydrate kinase activity
DTW94_RS27575	COG4213	ABC transporter substrate-binding protein
DTW94_RS27585	COG4214	carbohydrate transport
DTW94_RS27590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DTW94_RS27595	COG0531	amino acid
DTW94_RS27610	COG1316	TRANSCRIPTIONal
DTW94_RS27615	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS27615	COG1024	Enoyl-CoA hydratase
DTW94_RS27620	COG0183	Belongs to the thiolase family
DTW94_RS27640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DTW94_RS27645	COG0446	pyridine nucleotide-disulphide oxidoreductase
DTW94_RS27655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DTW94_RS27660	COG3253	May function as heme-dependent peroxidase
DTW94_RS27675	COG3220	belongs to the UPF0276 family
DTW94_RS27700	COG2376	Dihydroxyacetone kinase
DTW94_RS27710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTW94_RS27750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DTW94_RS27755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DTW94_RS27790	COG2072	flavoprotein involved in K transport
DTW94_RS27820	COG0483	inositol monophosphate 1-phosphatase activity
DTW94_RS27850	COG1100	Small GTP-binding protein
DTW94_RS27875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DTW94_RS27875	COG0515	serine threonine protein kinase
DTW94_RS27880	COG1063	alcohol dehydrogenase
DTW94_RS27885	COG0156	8-amino-7-oxononanoate synthase activity
DTW94_RS27900	COG0346	lactoylglutathione lyase activity
DTW94_RS27920	COG2723	6-phospho-beta-galactosidase activity
DTW94_RS27975	COG1175	transmembrane transport
DTW94_RS27995	COG1404	Belongs to the peptidase S8 family
DTW94_RS28010	COG1132	(ABC) transporter
DTW94_RS28015	COG1132	(ABC) transporter
DTW94_RS28025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DTW94_RS28035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTW94_RS28040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DTW94_RS28060	COG0529	Catalyzes the synthesis of activated sulfate
DTW94_RS28065	COG0175	sulfate reduction
DTW94_RS28090	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS28110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS28115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DTW94_RS28120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DTW94_RS28125	COG0583	DNA-binding transcription factor activity
DTW94_RS28130	COG0183	Belongs to the thiolase family
DTW94_RS28135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DTW94_RS28185	COG1162	GTPase activity
DTW94_RS28205	COG1404	Belongs to the peptidase S8 family
DTW94_RS28215	COG0028	Belongs to the TPP enzyme family
DTW94_RS28235	COG1802	Transcriptional regulator
DTW94_RS28260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DTW94_RS28265	COG2252	PERMEase
DTW94_RS28270	COG3608	succinylglutamate desuccinylase aspartoacylase
DTW94_RS28270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DTW94_RS28295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS28325	COG0435	Glutathione S-transferase
DTW94_RS28335	COG2197	response regulator
DTW94_RS28340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DTW94_RS28345	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS28365	COG3960	tartronate-semialdehyde synthase activity
DTW94_RS28380	COG3903	Transcriptional regulator
DTW94_RS28380	COG3629	intracellular signal transduction
DTW94_RS28390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS28400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DTW94_RS28410	COG0436	Aminotransferase
DTW94_RS28415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DTW94_RS28430	COG0753	catalase activity
DTW94_RS28435	COG2084	Dehydrogenase
DTW94_RS28440	COG3622	Belongs to the hyi family
DTW94_RS28445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DTW94_RS28455	COG0395	ABC-type sugar transport system, permease component
DTW94_RS28460	COG1175	transmembrane transport
DTW94_RS28470	COG2188	Transcriptional regulator
DTW94_RS28490	COG2351	hydroxyisourate hydrolase activity
DTW94_RS28500	COG2233	PERMEase
DTW94_RS28510	COG2233	PERMEase
DTW94_RS28555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DTW94_RS28570	COG2197	response regulator
DTW94_RS28590	COG1414	Transcriptional regulator
DTW94_RS28595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DTW94_RS28600	COG4266	Belongs to the allantoicase family
DTW94_RS28605	COG0656	L-ascorbic acid biosynthetic process
DTW94_RS28610	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS28650	COG0673	inositol 2-dehydrogenase activity
DTW94_RS28655	COG2188	Transcriptional regulator
DTW94_RS28670	COG1129	ABC transporter
DTW94_RS28675	COG1940	carbohydrate kinase activity
DTW94_RS28685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DTW94_RS28690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DTW94_RS28705	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS28740	COG1126	abc transporter atp-binding protein
DTW94_RS28745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DTW94_RS28750	COG0765	amino acid transport
DTW94_RS28755	COG0765	amino acid transport
DTW94_RS28765	COG1376	ErfK ybiS ycfS ynhG family protein
DTW94_RS28780	COG0405	Gamma-glutamyltransferase
DTW94_RS28810	COG0667	Aldo Keto reductase
DTW94_RS28820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DTW94_RS28825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DTW94_RS28850	COG2838	Isocitrate dehydrogenase
DTW94_RS28860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DTW94_RS28870	COG0095	Lipoate-protein ligase
DTW94_RS28875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DTW94_RS28890	COG1024	Enoyl-CoA hydratase
DTW94_RS28895	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS28915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DTW94_RS28930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DTW94_RS28970	COG1024	Enoyl-CoA hydratase
DTW94_RS28975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS29005	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS29010	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS29015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS29020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS29030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DTW94_RS29040	COG1131	(ABC) transporter
DTW94_RS29045	COG1024	Enoyl-CoA hydratase
DTW94_RS29080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DTW94_RS29095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DTW94_RS29110	COG1929	Belongs to the glycerate kinase type-1 family
DTW94_RS29130	COG0559	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS29135	COG0559	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS29165	COG0688	phosphatidylethanolamine metabolic process
DTW94_RS29170	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS29180	COG2301	Belongs to the HpcH HpaI aldolase family
DTW94_RS29185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS29185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DTW94_RS29190	COG0604	alcohol dehydrogenase
DTW94_RS29195	COG0456	acetyltransferase
DTW94_RS29210	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS29245	COG0667	Aldo Keto reductase
DTW94_RS29255	COG2362	D-Aminopeptidase
DTW94_RS29260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DTW94_RS29270	COG1619	proteins homologs of microcin C7 resistance protein MccF
DTW94_RS29285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DTW94_RS29300	COG4106	trans-aconitate 2-methyltransferase activity
DTW94_RS29320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DTW94_RS29345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DTW94_RS29360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTW94_RS29360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DTW94_RS29385	COG2154	pterin-4-alpha-carbinolamine dehydratase
DTW94_RS29395	COG4106	trans-aconitate 2-methyltransferase activity
DTW94_RS29405	COG0656	L-ascorbic acid biosynthetic process
DTW94_RS29415	COG0583	DNA-binding transcription factor activity
DTW94_RS29430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DTW94_RS29435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS29445	COG1129	ABC transporter
DTW94_RS29450	COG1172	Belongs to the binding-protein-dependent transport system permease family
DTW94_RS29460	COG0673	inositol 2-dehydrogenase activity
DTW94_RS29540	COG1129	ABC transporter
DTW94_RS29550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DTW94_RS29555	COG1869	D-ribose catabolic process
DTW94_RS29580	COG5002	protein histidine kinase activity
DTW94_RS29585	COG0745	RESPONSE REGULATOR receiver
DTW94_RS29615	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS29625	COG0517	IMP dehydrogenase activity
DTW94_RS29625	COG4175	Glycine betaine
DTW94_RS29630	COG4176	ABC-type proline glycine betaine transport system permease component
DTW94_RS29640	COG2124	cytochrome p450
DTW94_RS29645	COG0569	domain protein
DTW94_RS29645	COG2985	domain, Protein
DTW94_RS29660	COG1070	Carbohydrate kinase
DTW94_RS29670	COG1940	carbohydrate kinase activity
DTW94_RS29695	COG1846	Transcriptional regulator
DTW94_RS29720	COG2124	cytochrome p450
DTW94_RS29725	COG1486	melibiose metabolic process
DTW94_RS29765	COG3012	SEC-C Motif Domain Protein
DTW94_RS29820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DTW94_RS29845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DTW94_RS29880	COG2208	phosphoserine phosphatase activity
DTW94_RS29880	COG2770	Histidine kinase
DTW94_RS29900	COG1793	dna ligase
DTW94_RS29980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DTW94_RS29985	COG0488	(ABC) transporter
DTW94_RS30000	COG1515	deoxyribonuclease V activity
DTW94_RS30005	COG3268	Saccharopine dehydrogenase
DTW94_RS30010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DTW94_RS30015	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS30020	COG0183	Belongs to the thiolase family
DTW94_RS30025	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS30025	COG1024	Enoyl-CoA hydratase
DTW94_RS30030	COG0789	Transcriptional regulator
DTW94_RS30055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DTW94_RS30075	COG0488	(ABC) transporter
DTW94_RS30080	COG2183	response to ionizing radiation
DTW94_RS30090	COG4977	sequence-specific DNA binding
DTW94_RS30100	COG1024	Enoyl-CoA hydratase
DTW94_RS30115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DTW94_RS30120	COG2226	methyltransferase
DTW94_RS30150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DTW94_RS30165	COG1388	LysM domain
DTW94_RS30165	COG1134	teichoic acid transport
DTW94_RS30170	COG1562	ergosterol biosynthetic process
DTW94_RS30180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DTW94_RS30190	COG1657	PFAM Prenyltransferase squalene oxidase
DTW94_RS30215	COG2365	Tyrosine phosphatase family
DTW94_RS30225	COG2755	lipolytic protein G-D-S-L family
DTW94_RS30235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DTW94_RS30275	COG3467	pyridoxamine 5'-phosphate
DTW94_RS30315	COG1609	Transcriptional regulator
DTW94_RS30320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DTW94_RS30330	COG1116	anion transmembrane transporter activity
DTW94_RS30360	COG3958	Transketolase
DTW94_RS30365	COG3959	Transketolase, thiamine diphosphate binding domain
DTW94_RS30390	COG1846	Transcriptional regulator
DTW94_RS30390	COG0456	acetyltransferase
DTW94_RS30430	COG1215	transferase activity, transferring glycosyl groups
DTW94_RS30455	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS30470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DTW94_RS30485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DTW94_RS30505	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS30525	COG3511	phospholipase C
DTW94_RS30535	COG2197	response regulator
DTW94_RS30540	COG3851	Histidine kinase
DTW94_RS30550	COG0247	lactate metabolic process
DTW94_RS30555	COG1139	Iron-sulfur cluster binding protein
DTW94_RS30560	COG1556	Lactate utilization protein
DTW94_RS30580	COG1672	PFAM Archaeal ATPase
DTW94_RS30580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DTW94_RS30590	COG0318	PFAM AMP-dependent synthetase and ligase
DTW94_RS30600	COG0156	8-amino-7-oxononanoate synthase activity
DTW94_RS30615	COG3321	synthase
DTW94_RS30615	COG0604	alcohol dehydrogenase
DTW94_RS30625	COG3321	synthase
DTW94_RS30625	COG0604	alcohol dehydrogenase
DTW94_RS30630	COG1250	3-hydroxyacyl-CoA dehydrogenase
DTW94_RS30655	COG3629	intracellular signal transduction
DTW94_RS30655	COG3903	Transcriptional regulator
DTW94_RS30680	COG1396	sequence-specific DNA binding
DTW94_RS30680	COG3800	Transcriptional regulator
DTW94_RS30685	COG2079	MmgE PrpD family protein
DTW94_RS30695	COG0301	tRNA thio-modification
DTW94_RS30715	COG1316	TRANSCRIPTIONal
DTW94_RS30725	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DTW94_RS30730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DTW94_RS30735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DTW94_RS30755	COG0714	Associated with various cellular activities
DTW94_RS30780	COG0831	urea catabolic process
DTW94_RS30790	COG0832	Belongs to the urease beta subunit family
DTW94_RS30790	COG0831	urea catabolic process
DTW94_RS30795	COG0804	urea catabolic process
DTW94_RS30800	COG0830	nickel cation binding
DTW94_RS30805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DTW94_RS30810	COG0829	nickel cation binding
DTW94_RS30835	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS30860	COG0446	pyridine nucleotide-disulphide oxidoreductase
DTW94_RS30860	COG1902	pentaerythritol trinitrate reductase activity
DTW94_RS30875	COG2409	Drug exporters of the RND superfamily
DTW94_RS30880	COG1846	Transcriptional regulator
DTW94_RS30935	COG1233	COG1233 Phytoene dehydrogenase and related
DTW94_RS30940	COG2130	NADP-dependent
DTW94_RS30945	COG2124	cytochrome p450
DTW94_RS30960	COG2080	2 iron, 2 sulfur cluster binding
DTW94_RS30965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DTW94_RS30970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DTW94_RS30985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DTW94_RS30995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DTW94_RS31005	COG0019	diaminopimelate decarboxylase activity
DTW94_RS31015	COG2837	iron assimilation
DTW94_RS31020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DTW94_RS31060	COG0596	Alpha beta hydrolase
DTW94_RS31070	COG0395	ABC-type sugar transport system, permease component
DTW94_RS31075	COG1175	transmembrane transport
DTW94_RS31085	COG1940	carbohydrate kinase activity
DTW94_RS31095	COG1652	LysM domain
DTW94_RS31130	COG0784	Response regulator, receiver
DTW94_RS31135	COG4251	negative regulation of phosphorylation
DTW94_RS31140	COG2201	protein-glutamate methylesterase activity
DTW94_RS31145	COG1191	sigma factor activity
DTW94_RS31185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DTW94_RS31205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DTW94_RS31210	COG3275	phosphorelay sensor kinase activity
DTW94_RS31285	COG0583	DNA-binding transcription factor activity
DTW94_RS31295	COG1053	succinate dehydrogenase
DTW94_RS31300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DTW94_RS31315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DTW94_RS31320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DTW94_RS31330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS31335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DTW94_RS31340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DTW94_RS31370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DTW94_RS31380	COG2197	response regulator
DTW94_RS31385	COG2423	ornithine cyclodeaminase activity
DTW94_RS31390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DTW94_RS31405	COG3360	Dodecin
DTW94_RS31425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DTW94_RS31430	COG0121	glutamine amidotransferase
DTW94_RS31435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DTW94_RS31440	COG3572	ergothioneine biosynthetic process
DTW94_RS31465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DTW94_RS31470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DTW94_RS31475	COG1834	amidinotransferase
DTW94_RS31490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DTW94_RS31505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DTW94_RS31530	COG1028	Short-chain dehydrogenase reductase Sdr
DTW94_RS31560	COG0243	molybdopterin cofactor binding
DTW94_RS31585	COG0747	negative chemotaxis
DTW94_RS31590	COG0601	transmembrane transport
DTW94_RS31595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS31600	COG0444	Belongs to the ABC transporter superfamily
DTW94_RS31605	COG4608	Belongs to the ABC transporter superfamily
DTW94_RS31610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DTW94_RS31615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DTW94_RS31625	COG0431	NADPH-dependent FMN reductase
DTW94_RS31675	COG1120	ATPase activity
DTW94_RS31685	COG0477	Major facilitator Superfamily
DTW94_RS31690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DTW94_RS31700	COG0254	rRNA binding
DTW94_RS31705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DTW94_RS31710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DTW94_RS31715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DTW94_RS31735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS31740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS31745	COG1120	ATPase activity
DTW94_RS31775	COG1132	(ABC) transporter
DTW94_RS31820	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS31845	COG0438	transferase activity, transferring glycosyl groups
DTW94_RS31845	COG0297	glycogen (starch) synthase activity
DTW94_RS31885	COG1174	glycine betaine transport
DTW94_RS31890	COG1174	glycine betaine transport
DTW94_RS31910	COG0517	IMP dehydrogenase activity
DTW94_RS31910	COG1125	glycine betaine transport
DTW94_RS31920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DTW94_RS31940	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS31945	COG1960	acyl-CoA dehydrogenase activity
DTW94_RS31960	COG0601	transmembrane transport
DTW94_RS31965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DTW94_RS31970	COG0444	Belongs to the ABC transporter superfamily
DTW94_RS32035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DTW94_RS32035	COG1796	DNA polymerase
DTW94_RS32120	COG1278	Cold shock
DTW94_RS32135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DTW94_RS32155	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DTW94_RS32195	COG5297	Belongs to the glycosyl hydrolase family 6
DTW94_RS32205	COG3300	MHYT domain
DTW94_RS32205	COG5001	Diguanylate cyclase
DTW94_RS32220	COG2146	nitrite reductase [NAD(P)H] activity
DTW94_RS32220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DTW94_RS32225	COG2146	nitrite reductase [NAD(P)H] activity
DTW94_RS32225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DTW94_RS32230	COG0243	molybdopterin cofactor binding
DTW94_RS32235	COG2223	nitrite transmembrane transporter activity
DTW94_RS32290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DTW94_RS32320	COG0745	RESPONSE REGULATOR receiver
DTW94_RS32330	COG1120	ATPase activity
DTW94_RS32380	COG4585	Histidine kinase
DTW94_RS32385	COG2197	response regulator
DTW94_RS32395	COG1136	(ABC) transporter
DTW94_RS32395	COG0577	efflux transmembrane transporter activity
DTW94_RS32410	COG1012	belongs to the aldehyde dehydrogenase family
DTW94_RS32430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DTW94_RS32435	COG3239	Fatty acid desaturase
DTW94_RS32455	COG2267	carboxylic ester hydrolase activity
DTW94_RS32470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DTW94_RS32475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DTW94_RS32480	COG0640	Transcriptional regulator
DTW94_RS32495	COG2018	Roadblock/LC7 domain
DTW94_RS32525	COG1024	Enoyl-CoA hydratase
DTW94_RS32565	COG1595	DNA-templated transcription, initiation
DTW94_RS32580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DTW94_RS32585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DTW94_RS32595	COG2340	Cysteine-rich secretory protein family
DTW94_RS32625	COG0488	(ABC) transporter
DTW94_RS32640	COG0009	L-threonylcarbamoyladenylate synthase
DTW94_RS32675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DTW94_RS32695	COG0142	geranyltranstransferase activity
DTW94_RS32700	COG5297	Belongs to the glycosyl hydrolase family 6
DTW94_RS32700	COG3250	beta-galactosidase activity
DTW94_RS32710	COG0789	Transcriptional regulator
DTW94_RS32715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DTW94_RS32730	COG1891	lyase activity
DTW94_RS32740	COG2890	protein-(glutamine-N5) methyltransferase activity
DTW94_RS32775	COG1175	transmembrane transport
DTW94_RS32780	COG0395	ABC-type sugar transport system, permease component
DTW94_RS32785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DTW94_RS32790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DTW94_RS32800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DTW94_RS32825	COG2367	Beta-lactamase
DTW94_RS32875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DTW94_RS32880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DTW94_RS32890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form