locus-tag	class	description
DA116_RS00020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS00025	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DA116_RS00045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DA116_RS00050	COG0612	Peptidase, M16
DA116_RS00055	COG1185	polyribonucleotide nucleotidyltransferase activity
DA116_RS00060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DA116_RS00070	COG1674	ftsk spoiiie
DA116_RS00205	COG1404	Belongs to the peptidase S8 family
DA116_RS00230	COG1404	Belongs to the peptidase S8 family
DA116_RS00265	COG0455	bacterial-type flagellum organization
DA116_RS00280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DA116_RS00285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DA116_RS00295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DA116_RS00310	COG0779	Required for maturation of 30S ribosomal subunits
DA116_RS00370	COG0442	prolyl-tRNA aminoacylation
DA116_RS00385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DA116_RS00390	COG0750	zinc metalloprotease
DA116_RS00395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DA116_RS00440	COG0395	ABC-type sugar transport system, permease component
DA116_RS00445	COG4209	transmembrane transport
DA116_RS00450	COG1653	transport
DA116_RS00465	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS00505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS00510	COG1177	transmembrane transport
DA116_RS00515	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA116_RS00520	COG3842	ATPase activity
DA116_RS00545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA116_RS00550	COG0584	glycerophosphoryl diester phosphodiesterase
DA116_RS00560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS00580	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS00595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA116_RS00620	COG0513	Belongs to the DEAD box helicase family
DA116_RS00625	COG1278	Cold shock
DA116_RS00635	COG3842	ATPase activity
DA116_RS00640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DA116_RS00660	COG0575	Belongs to the CDS family
DA116_RS00665	COG0233	cytoplasmic translational termination
DA116_RS00670	COG0528	UMP kinase activity
DA116_RS00675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DA116_RS00680	COG0052	Belongs to the universal ribosomal protein uS2 family
DA116_RS00685	COG4942	peptidase
DA116_RS00695	COG1191	sigma factor activity
DA116_RS00710	COG0792	nuclease activity
DA116_RS00730	COG0681	Belongs to the peptidase S26 family
DA116_RS00745	COG0335	large ribosomal subunit rRNA binding
DA116_RS00750	COG0336	Belongs to the RNA methyltransferase TrmD family
DA116_RS00755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DA116_RS00760	COG1837	Belongs to the UPF0109 family
DA116_RS00765	COG0228	four-way junction DNA binding
DA116_RS00775	COG0442	prolyl-tRNA aminoacylation
DA116_RS00785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA116_RS00795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DA116_RS00830	COG0477	Major facilitator Superfamily
DA116_RS00835	COG1196	nuclear chromosome segregation
DA116_RS00845	COG1254	Belongs to the acylphosphatase family
DA116_RS00850	COG2340	Cysteine-rich secretory protein family
DA116_RS00855	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA116_RS00860	COG1733	regulation of RNA biosynthetic process
DA116_RS00865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA116_RS00870	COG0571	ribonuclease III activity
DA116_RS00875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DA116_RS00890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DA116_RS00895	COG0742	ribosomal rna small subunit methyltransferase
DA116_RS00915	COG1461	Dihydroxyacetone kinase
DA116_RS00920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DA116_RS00925	COG0351	phosphomethylpyrimidine kinase
DA116_RS00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
DA116_RS00950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DA116_RS00960	COG1920	GTP binding
DA116_RS00970	COG0776	regulation of translation
DA116_RS00980	COG0066	3-isopropylmalate dehydratase activity
DA116_RS00985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DA116_RS00990	COG1414	Transcriptional regulator
DA116_RS01045	COG0179	Fumarylacetoacetate (FAA) hydrolase
DA116_RS01060	COG2018	Roadblock/LC7 domain
DA116_RS01080	COG2018	Roadblock/LC7 domain
DA116_RS01100	COG5492	domain, Protein
DA116_RS01105	COG2353	YceI-like domain
DA116_RS01150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA116_RS01170	COG0804	urea catabolic process
DA116_RS01175	COG0831	urea catabolic process
DA116_RS01175	COG0832	Belongs to the urease beta subunit family
DA116_RS01185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA116_RS01190	COG0473	3-isopropylmalate dehydrogenase activity
DA116_RS01215	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS01220	COG0506	proline dehydrogenase activity
DA116_RS01225	COG3835	regulator
DA116_RS01255	COG0440	acetolactate synthase activity
DA116_RS01275	COG0667	Aldo Keto reductase
DA116_RS01280	COG2133	pyrroloquinoline quinone binding
DA116_RS01290	COG2197	response regulator
DA116_RS01305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS01310	COG2409	Drug exporters of the RND superfamily
DA116_RS01320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA116_RS01325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DA116_RS01335	COG0154	amidase activity
DA116_RS01340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DA116_RS01365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA116_RS01375	COG4221	oxidoreductase activity
DA116_RS01380	COG1611	Belongs to the LOG family
DA116_RS01400	COG0482	sulfurtransferase activity
DA116_RS01440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DA116_RS01445	COG2860	membrane
DA116_RS01450	COG4608	Belongs to the ABC transporter superfamily
DA116_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS01490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DA116_RS01495	COG0509	glycine decarboxylation via glycine cleavage system
DA116_RS01500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA116_RS01505	COG1760	l-serine dehydratase
DA116_RS01545	COG1376	ErfK ybiS ycfS ynhG family protein
DA116_RS01560	COG3119	arylsulfatase activity
DA116_RS01565	COG2197	response regulator
DA116_RS01570	COG4585	Histidine kinase
DA116_RS01580	COG1131	(ABC) transporter
DA116_RS01585	COG1132	(ABC) transporter
DA116_RS01590	COG1132	(ABC) transporter
DA116_RS01600	COG1132	(ABC) transporter
DA116_RS01625	COG0058	SHG alpha-glucan phosphorylase activity
DA116_RS01635	COG0366	Alpha amylase catalytic
DA116_RS01650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DA116_RS01670	COG1522	sequence-specific DNA binding
DA116_RS01680	COG0667	Aldo Keto reductase
DA116_RS01685	COG1301	dicarboxylic acid transport
DA116_RS01690	COG3290	protein histidine kinase activity
DA116_RS01695	COG4565	transcriptional regulatory protein
DA116_RS01705	COG1175	transmembrane transport
DA116_RS01710	COG0395	ABC-type sugar transport system, permease component
DA116_RS01715	COG0259	pyridoxamine-phosphate oxidase activity
DA116_RS01725	COG0205	6-phosphofructokinase activity
DA116_RS01730	COG0280	phosphate acetyltransferase
DA116_RS01730	COG0857	belongs to the CobB CobQ family
DA116_RS01735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DA116_RS01775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS01775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS01790	COG2329	Antibiotic biosynthesis monooxygenase
DA116_RS01795	COG2124	cytochrome p450
DA116_RS01805	COG2159	amidohydrolase
DA116_RS01880	COG0642	Histidine kinase
DA116_RS01880	COG3850	Histidine kinase
DA116_RS01885	COG0745	RESPONSE REGULATOR receiver
DA116_RS01905	COG0183	Belongs to the thiolase family
DA116_RS01910	COG0346	lactoylglutathione lyase activity
DA116_RS01925	COG1131	(ABC) transporter
DA116_RS01960	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DA116_RS01975	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA116_RS02005	COG4585	Histidine kinase
DA116_RS02010	COG2197	response regulator
DA116_RS02025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DA116_RS02030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DA116_RS02035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DA116_RS02040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DA116_RS02045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DA116_RS02055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DA116_RS02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA116_RS02075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA116_RS02080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA116_RS02090	COG2890	protein-(glutamine-N5) methyltransferase activity
DA116_RS02095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA116_RS02100	COG0254	rRNA binding
DA116_RS02120	COG0083	homoserine kinase activity
DA116_RS02130	COG0460	homoserine dehydrogenase
DA116_RS02135	COG0019	diaminopimelate decarboxylase activity
DA116_RS02140	COG0018	arginyl-trna synthetase
DA116_RS02225	COG1660	Displays ATPase and GTPase activities
DA116_RS02245	COG2186	Transcriptional regulator
DA116_RS02280	COG2814	Major facilitator Superfamily
DA116_RS02285	COG3251	PFAM MbtH domain protein
DA116_RS02290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA116_RS02355	COG2205	protein histidine kinase activity
DA116_RS02370	COG0768	penicillin binding
DA116_RS02410	COG0791	NLP P60 protein
DA116_RS02455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA116_RS02470	COG0745	RESPONSE REGULATOR receiver
DA116_RS02475	COG2205	protein histidine kinase activity
DA116_RS02480	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA116_RS02480	COG0567	Dehydrogenase, E1 component
DA116_RS02510	COG0542	response to heat
DA116_RS02520	COG0604	alcohol dehydrogenase
DA116_RS02525	COG0281	malic enzyme
DA116_RS02550	COG1595	DNA-templated transcription, initiation
DA116_RS02555	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS02650	COG0142	geranyltranstransferase activity
DA116_RS02655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA116_RS02665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DA116_RS02695	COG1597	lipid kinase activity
DA116_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS02720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA116_RS02725	COG0363	glucosamine-6-phosphate deaminase activity
DA116_RS02735	COG1476	TRANSCRIPTIONal
DA116_RS02740	COG1472	Belongs to the glycosyl hydrolase 3 family
DA116_RS02745	COG0395	ABC-type sugar transport system, permease component
DA116_RS02750	COG1175	transmembrane transport
DA116_RS02755	COG2182	Extracellular solute-binding protein
DA116_RS02760	COG2188	Transcriptional regulator
DA116_RS02765	COG1966	Carbon starvation protein
DA116_RS02815	COG2124	cytochrome p450
DA116_RS02825	COG0242	peptide deformylase activity
DA116_RS02840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DA116_RS02840	COG2199	diguanylate cyclase activity
DA116_RS02845	COG5662	AntiSigma factor
DA116_RS02850	COG1595	DNA-templated transcription, initiation
DA116_RS02860	COG2135	peptidase activity
DA116_RS02885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DA116_RS02890	COG1162	GTPase activity
DA116_RS02905	COG0483	inositol monophosphate 1-phosphatase activity
DA116_RS02915	COG0753	catalase activity
DA116_RS02955	COG1615	UPF0182 protein
DA116_RS02965	COG3480	Lon protease (S16) C-terminal proteolytic domain
DA116_RS03015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA116_RS03055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS03060	COG0210	DNA helicase
DA116_RS03085	COG0596	Alpha beta hydrolase
DA116_RS03125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS03130	COG4166	transmembrane transport
DA116_RS03175	COG0513	Belongs to the DEAD box helicase family
DA116_RS03180	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DA116_RS03185	COG1432	Conserved Protein
DA116_RS03210	COG2814	Major facilitator Superfamily
DA116_RS03220	COG0598	Magnesium transport protein CorA
DA116_RS03255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA116_RS03270	COG1595	DNA-templated transcription, initiation
DA116_RS03285	COG1024	Enoyl-CoA hydratase
DA116_RS03290	COG2818	Glycosylase
DA116_RS03300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA116_RS03305	COG1611	Belongs to the LOG family
DA116_RS03310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS03345	COG2197	response regulator
DA116_RS03360	COG1131	(ABC) transporter
DA116_RS03375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA116_RS03390	COG4608	Belongs to the ABC transporter superfamily
DA116_RS03400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS03405	COG0601	transmembrane transport
DA116_RS03425	COG0601	transmembrane transport
DA116_RS03430	COG0444	Belongs to the ABC transporter superfamily
DA116_RS03435	COG4608	Belongs to the ABC transporter superfamily
DA116_RS03450	COG0346	lactoylglutathione lyase activity
DA116_RS03460	COG4608	Belongs to the ABC transporter superfamily
DA116_RS03465	COG0444	Belongs to the ABC transporter superfamily
DA116_RS03470	COG0601	transmembrane transport
DA116_RS03480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS03485	COG1217	gtp-binding protein TYPA
DA116_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS03570	COG0583	DNA-binding transcription factor activity
DA116_RS03590	COG0012	GTP binding
DA116_RS03615	COG1722	exodeoxyribonuclease VII activity
DA116_RS03620	COG0778	Nitroreductase
DA116_RS03645	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DA116_RS03645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DA116_RS03650	COG0114	fumarate hydratase activity
DA116_RS03665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS03685	COG1136	(ABC) transporter
DA116_RS03715	COG0450	alkyl hydroperoxide reductase
DA116_RS03720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS03730	COG0741	lytic transglycosylase activity
DA116_RS03735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DA116_RS03740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA116_RS03755	COG2318	DinB family
DA116_RS03775	COG2885	chlorophyll binding
DA116_RS03795	COG2197	response regulator
DA116_RS03800	COG3850	Histidine kinase
DA116_RS03830	COG2894	cell division
DA116_RS03900	COG2610	gluconate transmembrane transporter activity
DA116_RS03910	COG1414	Transcriptional regulator
DA116_RS03925	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DA116_RS03940	COG0436	Aminotransferase
DA116_RS03975	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DA116_RS03985	COG0477	Major facilitator Superfamily
DA116_RS03990	COG1309	transcriptional regulator
DA116_RS04020	COG1331	Highly conserved protein containing a thioredoxin domain
DA116_RS04025	COG2255	four-way junction helicase activity
DA116_RS04035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA116_RS04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA116_RS04065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA116_RS04095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA116_RS04160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA116_RS04235	COG4941	Belongs to the sigma-70 factor family
DA116_RS04240	COG3795	YCII-related domain
DA116_RS04245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA116_RS04260	COG1064	alcohol dehydrogenase
DA116_RS04275	COG1404	Belongs to the peptidase S8 family
DA116_RS04280	COG1136	(ABC) transporter
DA116_RS04320	COG1024	Enoyl-CoA hydratase
DA116_RS04330	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS04340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA116_RS04355	COG0424	maF-like protein
DA116_RS04365	COG4770	biotin carboxylase activity
DA116_RS04400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA116_RS04440	COG0745	RESPONSE REGULATOR receiver
DA116_RS04445	COG2205	protein histidine kinase activity
DA116_RS04470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA116_RS04480	COG0583	DNA-binding transcription factor activity
DA116_RS04515	COG1079	Belongs to the binding-protein-dependent transport system permease family
DA116_RS04530	COG1744	ABC transporter substrate-binding protein PnrA-like
DA116_RS04540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DA116_RS04540	COG1473	amidohydrolase
DA116_RS04545	COG2226	methyltransferase
DA116_RS04555	COG2089	acid synthase
DA116_RS04570	COG1216	Glycosyl transferase, family 2
DA116_RS04590	COG1216	Glycosyl transferase, family 2
DA116_RS04610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS04610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS04685	COG2009	succinate dehydrogenase
DA116_RS04695	COG1053	succinate dehydrogenase
DA116_RS04740	COG1309	transcriptional regulator
DA116_RS04745	COG2409	Drug exporters of the RND superfamily
DA116_RS04750	COG0745	RESPONSE REGULATOR receiver
DA116_RS04755	COG2205	protein histidine kinase activity
DA116_RS04770	COG1408	metallophosphoesterase
DA116_RS04780	COG1686	Belongs to the peptidase S11 family
DA116_RS04785	COG1295	ribonuclease BN
DA116_RS04795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DA116_RS04820	COG0180	Tryptophanyl-tRNA synthetase
DA116_RS04825	COG1595	DNA-templated transcription, initiation
DA116_RS04845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA116_RS04860	COG0754	glutathionylspermidine amidase activity
DA116_RS04875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA116_RS04880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS04885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS04900	COG4176	ABC-type proline glycine betaine transport system permease component
DA116_RS04905	COG0517	IMP dehydrogenase activity
DA116_RS04905	COG4175	Glycine betaine
DA116_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS04980	COG3903	Transcriptional regulator
DA116_RS04980	COG3629	intracellular signal transduction
DA116_RS04985	COG0039	L-malate dehydrogenase activity
DA116_RS05005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DA116_RS05020	COG0515	serine threonine protein kinase
DA116_RS05020	COG2815	serine threonine protein kinase
DA116_RS05030	COG2815	serine threonine protein kinase
DA116_RS05030	COG0515	serine threonine protein kinase
DA116_RS05060	COG0138	bifunctional purine biosynthesis protein purh
DA116_RS05105	COG0045	succinate-CoA ligase (ADP-forming) activity
DA116_RS05120	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DA116_RS05125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DA116_RS05130	COG0714	Associated with various cellular activities
DA116_RS05145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS05145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS05185	COG2197	response regulator
DA116_RS05230	COG0519	Catalyzes the synthesis of GMP from XMP
DA116_RS05230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DA116_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS05260	COG0515	serine threonine protein kinase
DA116_RS05265	COG0515	serine threonine protein kinase
DA116_RS05290	COG2815	serine threonine protein kinase
DA116_RS05290	COG0515	serine threonine protein kinase
DA116_RS05300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA116_RS05310	COG0516	GMP reductase activity
DA116_RS05335	COG0583	DNA-binding transcription factor activity
DA116_RS05345	COG4221	oxidoreductase activity
DA116_RS05355	COG0459	protein refolding
DA116_RS05360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DA116_RS05365	COG0726	polysaccharide deacetylase
DA116_RS05370	COG0726	polysaccharide deacetylase
DA116_RS05380	COG4941	Belongs to the sigma-70 factor family
DA116_RS05390	COG1316	TRANSCRIPTIONal
DA116_RS05395	COG1609	Transcriptional regulator
DA116_RS05410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DA116_RS05435	COG0802	atpase or kinase
DA116_RS05445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA116_RS05455	COG0736	holo-[acyl-carrier-protein] synthase activity
DA116_RS05465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS05475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA116_RS05505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DA116_RS05510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DA116_RS05545	COG2843	Capsule synthesis protein
DA116_RS05555	COG0101	tRNA pseudouridine synthase activity
DA116_RS05560	COG0203	ribosomal protein L17
DA116_RS05570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DA116_RS05575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DA116_RS05580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DA116_RS05585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DA116_RS05595	COG0563	adenylate kinase activity
DA116_RS05600	COG0201	protein transport
DA116_RS05605	COG0200	Binds to the 23S rRNA
DA116_RS05610	COG1841	ribosomal large subunit assembly
DA116_RS05615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DA116_RS05620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DA116_RS05625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DA116_RS05630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DA116_RS05640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DA116_RS05645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DA116_RS05650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DA116_RS05655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DA116_RS05660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DA116_RS05665	COG0255	Belongs to the universal ribosomal protein uL29 family
DA116_RS05670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DA116_RS05675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DA116_RS05680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DA116_RS05685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DA116_RS05690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DA116_RS05695	COG0089	rRNA binding
DA116_RS05700	COG0088	Forms part of the polypeptide exit tunnel
DA116_RS05705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DA116_RS05710	COG0051	transcription antitermination factor activity, RNA binding
DA116_RS05725	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DA116_RS05730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DA116_RS05740	COG2133	pyrroloquinoline quinone binding
DA116_RS05750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DA116_RS05755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA116_RS05760	COG0049	tRNA binding
DA116_RS05765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DA116_RS05775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DA116_RS05780	COG0085	RNA polymerase activity
DA116_RS05790	COG0222	ribosome binding
DA116_RS05795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DA116_RS05810	COG0081	regulation of translation
DA116_RS05815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DA116_RS05825	COG0250	Participates in transcription elongation, termination and antitermination
DA116_RS05840	COG0436	Aminotransferase
DA116_RS05845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA116_RS05855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA116_RS05860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DA116_RS05870	COG0477	Major facilitator Superfamily
DA116_RS05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DA116_RS05925	COG1666	GTP binding
DA116_RS05930	COG2261	transglycosylase associated protein
DA116_RS05945	COG3304	Inner membrane component domain
DA116_RS05950	COG0501	Belongs to the peptidase M48B family
DA116_RS05955	COG1007	ATP synthesis coupled electron transport
DA116_RS05965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA116_RS05970	COG0713	ATP synthesis coupled electron transport
DA116_RS05975	COG0839	Belongs to the complex I subunit 6 family
DA116_RS05980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS05990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS06000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS06020	COG0674	pyruvate-flavodoxin oxidoreductase activity
DA116_RS06020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DA116_RS06025	COG1013	pyruvate-flavodoxin oxidoreductase activity
DA116_RS06040	COG1733	regulation of RNA biosynthetic process
DA116_RS06045	COG0702	epimerase
DA116_RS06060	COG2234	aminopeptidase activity
DA116_RS06060	COG4935	Belongs to the peptidase S8 family
DA116_RS06080	COG0154	amidase activity
DA116_RS06095	COG1131	(ABC) transporter
DA116_RS06110	COG0142	geranyltranstransferase activity
DA116_RS06120	COG0561	phosphatase activity
DA116_RS06135	COG0514	ATP-dependent DNA helicase (RecQ)
DA116_RS06140	COG1007	ATP synthesis coupled electron transport
DA116_RS06150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DA116_RS06155	COG0713	ATP synthesis coupled electron transport
DA116_RS06160	COG0839	Belongs to the complex I subunit 6 family
DA116_RS06165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS06170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DA116_RS06175	COG1034	ATP synthesis coupled electron transport
DA116_RS06180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DA116_RS06190	COG0649	NAD binding
DA116_RS06195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS06200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS06215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DA116_RS06215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS06220	COG0242	peptide deformylase activity
DA116_RS06240	COG2226	methyltransferase
DA116_RS06270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DA116_RS06285	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DA116_RS06290	COG1278	Cold shock
DA116_RS06315	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS06320	COG1053	succinate dehydrogenase
DA116_RS06330	COG4213	ABC transporter substrate-binding protein
DA116_RS06360	COG1309	transcriptional regulator
DA116_RS06385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DA116_RS06395	COG0163	prenyltransferase activity
DA116_RS06410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DA116_RS06445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA116_RS06450	COG1333	cytochrome c biogenesis protein
DA116_RS06455	COG0785	Cytochrome C biogenesis protein
DA116_RS06460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA116_RS06470	COG0406	alpha-ribazole phosphatase activity
DA116_RS06475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DA116_RS06505	COG0583	DNA-binding transcription factor activity
DA116_RS06525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA116_RS06540	COG2175	clavaminate synthase activity
DA116_RS06580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS06590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS06610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS06625	COG0604	alcohol dehydrogenase
DA116_RS06630	COG1733	regulation of RNA biosynthetic process
DA116_RS06640	COG1742	UPF0060 membrane protein
DA116_RS06660	COG1690	Belongs to the RtcB family
DA116_RS06685	COG0018	arginyl-trna synthetase
DA116_RS06715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA116_RS06725	COG0113	porphobilinogen synthase activity
DA116_RS06740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA116_RS06740	COG1648	precorrin-2 dehydrogenase activity
DA116_RS06745	COG0181	hydroxymethylbilane synthase activity
DA116_RS06750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DA116_RS06755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DA116_RS06810	COG0123	including yeast histone deacetylase and acetoin utilization protein
DA116_RS06825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA116_RS06850	COG0180	Tryptophanyl-tRNA synthetase
DA116_RS06855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA116_RS06865	COG0842	Transport permease protein
DA116_RS06865	COG1129	ABC transporter
DA116_RS06880	COG4991	sh3 domain protein
DA116_RS06885	COG4991	sh3 domain protein
DA116_RS06895	COG0129	dihydroxy-acid dehydratase activity
DA116_RS06905	COG1082	Xylose isomerase domain protein TIM barrel
DA116_RS06910	COG0248	Ppx GppA phosphatase
DA116_RS06930	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DA116_RS06940	COG1194	a g-specific adenine glycosylase
DA116_RS06945	COG1595	DNA-templated transcription, initiation
DA116_RS06955	COG0745	RESPONSE REGULATOR receiver
DA116_RS06960	COG2205	protein histidine kinase activity
DA116_RS06975	COG0477	Major facilitator Superfamily
DA116_RS06985	COG0739	heme binding
DA116_RS07025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA116_RS07045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DA116_RS07055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA116_RS07060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DA116_RS07070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DA116_RS07090	COG1660	Displays ATPase and GTPase activities
DA116_RS07095	COG2197	response regulator
DA116_RS07110	COG0649	NAD binding
DA116_RS07150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA116_RS07165	COG0302	gtp cyclohydrolase
DA116_RS07190	COG2027	D-alanyl-D-alanine carboxypeptidase
DA116_RS07195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DA116_RS07205	COG0586	Pfam SNARE associated Golgi protein
DA116_RS07210	COG0393	Putative heavy-metal-binding
DA116_RS07215	COG0789	Transcriptional regulator
DA116_RS07240	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS07270	COG0346	lactoylglutathione lyase activity
DA116_RS07275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DA116_RS07285	COG0254	rRNA binding
DA116_RS07290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DA116_RS07295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DA116_RS07300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DA116_RS07325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA116_RS07325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA116_RS07385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DA116_RS07390	COG1754	DNA topoisomerase type I activity
DA116_RS07390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA116_RS07415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DA116_RS07420	COG2172	sigma factor antagonist activity
DA116_RS07425	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS07430	COG1205	dead DEAH box helicase
DA116_RS07430	COG1111	helicase
DA116_RS07490	COG0659	secondary active sulfate transmembrane transporter activity
DA116_RS07495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA116_RS07510	COG2267	carboxylic ester hydrolase activity
DA116_RS07545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA116_RS07570	COG0003	Pfam Anion-transporting ATPase
DA116_RS07585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS07595	COG1408	metallophosphoesterase
DA116_RS07680	COG2188	Transcriptional regulator
DA116_RS07685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DA116_RS07700	COG0270	DNA (cytosine-5-)-methyltransferase activity
DA116_RS07760	COG1316	TRANSCRIPTIONal
DA116_RS07780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA116_RS07790	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS07830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS07835	COG1595	DNA-templated transcription, initiation
DA116_RS07840	COG4249	Peptidase C14 caspase catalytic subunit p20
DA116_RS07840	COG2319	Wd-40 repeat
DA116_RS07865	COG0701	Predicted permease
DA116_RS07890	COG1595	DNA-templated transcription, initiation
DA116_RS07920	COG2205	protein histidine kinase activity
DA116_RS07945	COG0384	phenazine biosynthesis protein PhzF
DA116_RS07955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DA116_RS07960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DA116_RS07990	COG0693	protein deglycase activity
DA116_RS07995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA116_RS08000	COG1802	Transcriptional regulator
DA116_RS08050	COG2197	response regulator
DA116_RS08055	COG4585	Histidine kinase
DA116_RS08060	COG0577	efflux transmembrane transporter activity
DA116_RS08060	COG1136	(ABC) transporter
DA116_RS08070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DA116_RS08085	COG1131	(ABC) transporter
DA116_RS08090	COG3559	Exporter of polyketide antibiotics
DA116_RS08100	COG2124	cytochrome p450
DA116_RS08110	COG2197	response regulator
DA116_RS08115	COG4585	Histidine kinase
DA116_RS08120	COG2197	response regulator
DA116_RS08125	COG4585	Histidine kinase
DA116_RS08150	COG3844	kynureninase activity
DA116_RS08155	COG3483	tryptophan 2,3-dioxygenase activity
DA116_RS08165	COG0477	Major facilitator Superfamily
DA116_RS08170	COG0191	fructose-bisphosphate aldolase activity
DA116_RS08175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA116_RS08190	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA116_RS08220	COG0542	response to heat
DA116_RS08260	COG1131	(ABC) transporter
DA116_RS08265	COG4213	ABC transporter substrate-binding protein
DA116_RS08280	COG0789	Transcriptional regulator
DA116_RS08285	COG0484	heat shock protein binding
DA116_RS08290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DA116_RS08295	COG0443	Heat shock 70 kDa protein
DA116_RS08300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA116_RS08305	COG0247	lactate metabolic process
DA116_RS08305	COG2181	nitrate reductase activity
DA116_RS08320	COG2814	Major facilitator Superfamily
DA116_RS08335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA116_RS08435	COG0717	Belongs to the dCTP deaminase family
DA116_RS08495	COG2188	Transcriptional regulator
DA116_RS08505	COG2188	Transcriptional regulator
DA116_RS08550	COG1278	Cold shock
DA116_RS08590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA116_RS08600	COG0640	Transcriptional regulator
DA116_RS08605	COG2226	methyltransferase
DA116_RS08625	COG0515	serine threonine protein kinase
DA116_RS08625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS08630	COG1846	Transcriptional regulator
DA116_RS08635	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS08645	COG2205	protein histidine kinase activity
DA116_RS08650	COG0745	RESPONSE REGULATOR receiver
DA116_RS08665	COG1376	ErfK ybiS ycfS ynhG family protein
DA116_RS08720	COG1846	Transcriptional regulator
DA116_RS08730	COG4977	sequence-specific DNA binding
DA116_RS08755	COG0531	amino acid
DA116_RS08760	COG4977	sequence-specific DNA binding
DA116_RS08780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA116_RS08785	COG0475	glutathione-regulated potassium exporter activity
DA116_RS08800	COG1834	amidinotransferase
DA116_RS08805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA116_RS08810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA116_RS08810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA116_RS08835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS08880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS08885	COG2814	Major facilitator Superfamily
DA116_RS08890	COG0248	Ppx GppA phosphatase
DA116_RS08925	COG1764	response to oxidative stress
DA116_RS08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA116_RS08995	COG0477	Major facilitator Superfamily
DA116_RS09005	COG4585	Histidine kinase
DA116_RS09010	COG2409	Drug exporters of the RND superfamily
DA116_RS09020	COG0714	Associated with various cellular activities
DA116_RS09045	COG3764	Sortase (surface protein transpeptidase)
DA116_RS09095	COG2226	methyltransferase
DA116_RS09095	COG1073	alpha beta
DA116_RS09150	COG0366	Alpha amylase catalytic
DA116_RS09165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DA116_RS09185	COG0701	Predicted permease
DA116_RS09200	COG0222	ribosome binding
DA116_RS09245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DA116_RS09255	COG1289	transmembrane transporter activity
DA116_RS09265	COG0583	DNA-binding transcription factor activity
DA116_RS09285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA116_RS09325	COG1741	Belongs to the pirin family
DA116_RS09330	COG0477	Major facilitator Superfamily
DA116_RS09350	COG1960	acyl-CoA dehydrogenase activity
DA116_RS09355	COG1362	aminopeptidase activity
DA116_RS09400	COG2814	Major facilitator Superfamily
DA116_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA116_RS09420	COG0022	dehydrogenase e1 component
DA116_RS09435	COG0515	serine threonine protein kinase
DA116_RS09440	COG0515	serine threonine protein kinase
DA116_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS09460	COG0604	alcohol dehydrogenase
DA116_RS09460	COG3321	synthase
DA116_RS09480	COG0303	'Molybdopterin
DA116_RS09515	COG1309	transcriptional regulator
DA116_RS09520	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA116_RS09545	COG1960	acyl-CoA dehydrogenase activity
DA116_RS09565	COG1733	regulation of RNA biosynthetic process
DA116_RS09570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA116_RS09585	COG1716	ATPase activity
DA116_RS09590	COG1716	ATPase activity
DA116_RS09605	COG0768	penicillin binding
DA116_RS09615	COG0515	serine threonine protein kinase
DA116_RS09620	COG3764	Sortase (surface protein transpeptidase)
DA116_RS09625	COG3764	Sortase (surface protein transpeptidase)
DA116_RS09640	COG3764	Sortase (surface protein transpeptidase)
DA116_RS09655	COG0705	Rhomboid family
DA116_RS09680	COG0515	serine threonine protein kinase
DA116_RS09700	COG1116	anion transmembrane transporter activity
DA116_RS09720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA116_RS09725	COG0187	DNA topoisomerase II activity
DA116_RS09730	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DA116_RS09735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DA116_RS09740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DA116_RS09745	COG0592	DNA-directed DNA polymerase activity
DA116_RS09755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DA116_RS09765	COG0594	ribonuclease P activity
DA116_RS09770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DA116_RS09775	COG0706	membrane insertase activity
DA116_RS09785	COG0357	Ribosomal RNA small subunit methyltransferase G
DA116_RS09790	COG1192	Involved in chromosome partitioning
DA116_RS09805	COG3118	belongs to the thioredoxin family
DA116_RS09810	COG0492	ferredoxin-NADP+ reductase activity
DA116_RS09820	COG1595	DNA-templated transcription, initiation
DA116_RS09825	COG0515	serine threonine protein kinase
DA116_RS09825	COG2815	serine threonine protein kinase
DA116_RS09840	COG0617	tRNA 3'-terminal CCA addition
DA116_RS09865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS09865	COG4499	WXG100 protein secretion system (Wss), protein YukC
DA116_RS09890	COG0360	Binds together with S18 to 16S ribosomal RNA
DA116_RS09895	COG0629	single-stranded DNA binding
DA116_RS09900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DA116_RS09905	COG0359	binds to the 23S rRNA
DA116_RS09915	COG0305	Participates in initiation and elongation during chromosome replication
DA116_RS09935	COG2814	Major facilitator Superfamily
DA116_RS09970	COG0626	cystathionine gamma-synthase activity
DA116_RS09975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA116_RS09980	COG1950	PFAM Membrane protein of
DA116_RS09985	COG0662	Cupin 2, conserved barrel domain protein
DA116_RS10010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DA116_RS10025	COG1609	Transcriptional regulator
DA116_RS10030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA116_RS10040	COG1271	oxidase subunit
DA116_RS10045	COG1294	oxidase, subunit
DA116_RS10050	COG4988	ABC transporter
DA116_RS10060	COG0561	phosphatase activity
DA116_RS10075	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DA116_RS10080	COG0789	Transcriptional regulator
DA116_RS10095	COG1131	(ABC) transporter
DA116_RS10125	COG0561	phosphatase activity
DA116_RS10140	COG2837	iron assimilation
DA116_RS10155	COG1999	signal sequence binding
DA116_RS10180	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DA116_RS10185	COG0006	proline dipeptidase activity
DA116_RS10205	COG0653	protein targeting
DA116_RS10225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA116_RS10230	COG0515	serine threonine protein kinase
DA116_RS10235	COG1278	Cold shock
DA116_RS10275	COG1595	DNA-templated transcription, initiation
DA116_RS10280	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS10325	COG0702	epimerase
DA116_RS10330	COG1733	regulation of RNA biosynthetic process
DA116_RS10335	COG1846	Transcriptional regulator
DA116_RS10350	COG0745	RESPONSE REGULATOR receiver
DA116_RS10355	COG2205	protein histidine kinase activity
DA116_RS10365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA116_RS10380	COG3467	pyridoxamine 5'-phosphate
DA116_RS10385	COG2353	YceI-like domain
DA116_RS10410	COG1191	sigma factor activity
DA116_RS10415	COG1191	sigma factor activity
DA116_RS10450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DA116_RS10465	COG0433	COG0433 Predicted ATPase
DA116_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS10520	COG1653	transport
DA116_RS10530	COG0395	ABC-type sugar transport system, permease component
DA116_RS10535	COG3345	alpha-galactosidase
DA116_RS10580	COG0477	Major facilitator Superfamily
DA116_RS10620	COG0151	Belongs to the GarS family
DA116_RS10635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DA116_RS10680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA116_RS10685	COG0047	phosphoribosylformylglycinamidine synthase activity
DA116_RS10690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA116_RS10920	COG3883	PFAM NLP P60 protein
DA116_RS10920	COG0791	NLP P60 protein
DA116_RS10945	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA116_RS10945	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS10975	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS11045	COG2226	methyltransferase
DA116_RS11105	COG1960	acyl-CoA dehydrogenase activity
DA116_RS11110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA116_RS11240	COG3547	Transposase (IS116 IS110 IS902 family)
DA116_RS11270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS11300	COG1136	(ABC) transporter
DA116_RS11315	COG0668	transmembrane transport
DA116_RS11325	COG1940	carbohydrate kinase activity
DA116_RS11335	COG1175	transmembrane transport
DA116_RS11340	COG0395	ABC-type sugar transport system, permease component
DA116_RS11345	COG1486	melibiose metabolic process
DA116_RS11390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DA116_RS11395	COG2346	COG2346, Truncated hemoglobins
DA116_RS11425	COG0629	single-stranded DNA binding
DA116_RS11480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA116_RS11485	COG0656	L-ascorbic acid biosynthetic process
DA116_RS11490	COG0477	Major facilitator Superfamily
DA116_RS11510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA116_RS11515	COG2091	lysine biosynthetic process via aminoadipic acid
DA116_RS11535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA116_RS11555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS11560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA116_RS11615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS11630	COG4770	biotin carboxylase activity
DA116_RS11665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA116_RS11725	COG0438	transferase activity, transferring glycosyl groups
DA116_RS11740	COG0728	peptidoglycan biosynthetic process
DA116_RS11750	COG0438	transferase activity, transferring glycosyl groups
DA116_RS11810	COG3962	Belongs to the TPP enzyme family
DA116_RS11825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS11835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS11845	COG2409	Drug exporters of the RND superfamily
DA116_RS11870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA116_RS11895	COG1129	ABC transporter
DA116_RS11900	COG1879	ABC-type sugar transport system periplasmic component
DA116_RS11905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS11910	COG1869	D-ribose catabolic process
DA116_RS11925	COG0673	inositol 2-dehydrogenase activity
DA116_RS11945	COG0456	acetyltransferase
DA116_RS11945	COG1846	Transcriptional regulator
DA116_RS11975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DA116_RS11980	COG1472	Belongs to the glycosyl hydrolase 3 family
DA116_RS12015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA116_RS12020	COG2356	endonuclease I
DA116_RS12030	COG0028	Belongs to the TPP enzyme family
DA116_RS12040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA116_RS12070	COG0586	Pfam SNARE associated Golgi protein
DA116_RS12075	COG1309	transcriptional regulator
DA116_RS12080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA116_RS12095	COG1960	acyl-CoA dehydrogenase activity
DA116_RS12120	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DA116_RS12155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA116_RS12165	COG0589	response to stress
DA116_RS12175	COG4977	sequence-specific DNA binding
DA116_RS12180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DA116_RS12205	COG1175	transmembrane transport
DA116_RS12230	COG0745	RESPONSE REGULATOR receiver
DA116_RS12240	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA116_RS12255	COG0406	alpha-ribazole phosphatase activity
DA116_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS12320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA116_RS12335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA116_RS12340	COG0765	amino acid transport
DA116_RS12345	COG0765	amino acid transport
DA116_RS12350	COG1126	abc transporter atp-binding protein
DA116_RS12375	COG3397	chitin binding
DA116_RS12465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS12470	COG2188	Transcriptional regulator
DA116_RS12480	COG1940	carbohydrate kinase activity
DA116_RS12485	COG0673	inositol 2-dehydrogenase activity
DA116_RS12490	COG4702	Belongs to the UPF0303 family
DA116_RS12500	COG0706	membrane insertase activity
DA116_RS12520	COG3764	Sortase (surface protein transpeptidase)
DA116_RS12570	COG1074	ATP-dependent DNA helicase activity
DA116_RS12655	COG3629	intracellular signal transduction
DA116_RS12655	COG3903	Transcriptional regulator
DA116_RS12700	COG2733	membrane
DA116_RS12715	COG4555	ABC transporter
DA116_RS12730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS12760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA116_RS12770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DA116_RS12775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA116_RS12780	COG1263	PTS System
DA116_RS12785	COG1263	PTS System
DA116_RS12790	COG1234	tRNA 3'-trailer cleavage
DA116_RS12820	COG1113	amino acid transport
DA116_RS12830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DA116_RS12840	COG1335	isochorismatase
DA116_RS12880	COG0277	FAD linked oxidase domain protein
DA116_RS12895	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DA116_RS12905	COG1174	glycine betaine transport
DA116_RS12915	COG1174	glycine betaine transport
DA116_RS12960	COG3654	unkown
DA116_RS13005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DA116_RS13015	COG1175	transmembrane transport
DA116_RS13030	COG1678	Uncharacterized ACR, COG1678
DA116_RS13035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA116_RS13040	COG0776	regulation of translation
DA116_RS13050	COG3973	AAA domain
DA116_RS13080	COG2223	nitrite transmembrane transporter activity
DA116_RS13115	COG0583	DNA-binding transcription factor activity
DA116_RS13125	COG2124	cytochrome p450
DA116_RS13130	COG2027	D-alanyl-D-alanine carboxypeptidase
DA116_RS13160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DA116_RS13165	COG0793	Belongs to the peptidase S41A family
DA116_RS13175	COG2884	Cell division ATP-binding protein ftsE
DA116_RS13190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DA116_RS13200	COG0515	serine threonine protein kinase
DA116_RS13215	COG1175	transmembrane transport
DA116_RS13220	COG0395	ABC-type sugar transport system, permease component
DA116_RS13225	COG0463	Glycosyl transferase, family 2
DA116_RS13225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA116_RS13230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DA116_RS13235	COG1216	Glycosyl transferase, family 2
DA116_RS13245	COG1764	response to oxidative stress
DA116_RS13250	COG1846	Transcriptional regulator
DA116_RS13265	COG2197	response regulator
DA116_RS13280	COG1134	teichoic acid transport
DA116_RS13285	COG2902	Dehydrogenase
DA116_RS13310	COG0653	protein targeting
DA116_RS13320	COG3214	Protein conserved in bacteria
DA116_RS13325	COG2197	response regulator
DA116_RS13330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA116_RS13345	COG0823	Involved in the tonB-independent uptake of proteins
DA116_RS13355	COG0745	RESPONSE REGULATOR receiver
DA116_RS13360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DA116_RS13430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA116_RS13430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA116_RS13430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA116_RS13455	COG2835	tetraacyldisaccharide 4'-kinase activity
DA116_RS13460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA116_RS13465	COG1620	l-lactate permease
DA116_RS13505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA116_RS13510	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DA116_RS13510	COG0778	Nitroreductase
DA116_RS13535	COG1316	TRANSCRIPTIONal
DA116_RS13540	COG1316	TRANSCRIPTIONal
DA116_RS13545	COG1316	TRANSCRIPTIONal
DA116_RS13555	COG1316	TRANSCRIPTIONal
DA116_RS13565	COG1316	TRANSCRIPTIONal
DA116_RS13580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA116_RS13600	COG0789	Transcriptional regulator
DA116_RS13605	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS13615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DA116_RS13630	COG2205	protein histidine kinase activity
DA116_RS13635	COG0745	RESPONSE REGULATOR receiver
DA116_RS13640	COG3104	oligopeptide transport
DA116_RS13670	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS13675	COG1191	sigma factor activity
DA116_RS13685	COG1228	amidohydrolase
DA116_RS13695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS13700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DA116_RS13740	COG2986	histidine ammonia-lyase
DA116_RS13750	COG1174	glycine betaine transport
DA116_RS13770	COG4221	oxidoreductase activity
DA116_RS13785	COG2755	lipolytic protein G-D-S-L family
DA116_RS13790	COG0183	Belongs to the thiolase family
DA116_RS13830	COG1136	(ABC) transporter
DA116_RS13835	COG1136	(ABC) transporter
DA116_RS13835	COG0577	efflux transmembrane transporter activity
DA116_RS13840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA116_RS13845	COG1252	NADH dehydrogenase
DA116_RS13870	COG0148	phosphopyruvate hydratase activity
DA116_RS13885	COG2124	cytochrome p450
DA116_RS13950	COG0577	efflux transmembrane transporter activity
DA116_RS13955	COG1136	(ABC) transporter
DA116_RS13960	COG0477	Major facilitator Superfamily
DA116_RS14005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA116_RS14045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DA116_RS14050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA116_RS14060	COG0193	aminoacyl-tRNA hydrolase activity
DA116_RS14075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DA116_RS14085	COG1309	transcriptional regulator
DA116_RS14100	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS14110	COG2197	response regulator
DA116_RS14125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA116_RS14165	COG0488	(ABC) transporter
DA116_RS14175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DA116_RS14180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA116_RS14185	COG3584	3D domain protein
DA116_RS14185	COG3583	domain protein
DA116_RS14190	COG0084	hydrolase, TatD family'
DA116_RS14225	COG0310	cobalt ion transport
DA116_RS14235	COG1122	ATPase activity
DA116_RS14240	COG1846	Transcriptional regulator
DA116_RS14245	COG1764	response to oxidative stress
DA116_RS14250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS14265	COG1073	alpha beta
DA116_RS14265	COG2226	methyltransferase
DA116_RS14290	COG0442	prolyl-tRNA aminoacylation
DA116_RS14295	COG2409	Drug exporters of the RND superfamily
DA116_RS14305	COG0793	Belongs to the peptidase S41A family
DA116_RS14305	COG4946	Tricorn protease homolog
DA116_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS14320	COG2267	carboxylic ester hydrolase activity
DA116_RS14325	COG2072	flavoprotein involved in K transport
DA116_RS14335	COG0708	Exodeoxyribonuclease III
DA116_RS14340	COG0454	-acetyltransferase
DA116_RS14360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS14365	COG0315	cyclic pyranopterin monophosphate synthase activity
DA116_RS14365	COG0521	Mo-molybdopterin cofactor biosynthetic process
DA116_RS14370	COG0315	cyclic pyranopterin monophosphate synthase activity
DA116_RS14380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA116_RS14385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DA116_RS14405	COG0477	Major facilitator Superfamily
DA116_RS14415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA116_RS14425	COG1970	mechanosensitive ion channel activity
DA116_RS14440	COG3191	aminopeptidase activity
DA116_RS14460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA116_RS14460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA116_RS14460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA116_RS14470	COG1349	DNA-binding transcription factor activity
DA116_RS14475	COG0477	Major facilitator Superfamily
DA116_RS14495	COG1247	-acetyltransferase
DA116_RS14505	COG1846	Transcriptional regulator
DA116_RS14525	COG1414	Transcriptional regulator
DA116_RS14615	COG2197	response regulator
DA116_RS14650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS14655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS14670	COG3251	PFAM MbtH domain protein
DA116_RS14695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA116_RS14700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA116_RS14705	COG3903	Transcriptional regulator
DA116_RS14705	COG3629	intracellular signal transduction
DA116_RS14715	COG2197	response regulator
DA116_RS14760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS14775	COG0386	Belongs to the glutathione peroxidase family
DA116_RS14885	COG2267	carboxylic ester hydrolase activity
DA116_RS14925	COG3903	Transcriptional regulator
DA116_RS14925	COG3629	intracellular signal transduction
DA116_RS14940	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS14955	COG1024	Enoyl-CoA hydratase
DA116_RS14965	COG0515	serine threonine protein kinase
DA116_RS14965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS14980	COG1309	transcriptional regulator
DA116_RS14985	COG1522	sequence-specific DNA binding
DA116_RS14990	COG1280	lysine exporter protein (LysE YggA)
DA116_RS15020	COG1960	acyl-CoA dehydrogenase activity
DA116_RS15040	COG0259	pyridoxamine-phosphate oxidase activity
DA116_RS15095	COG1595	DNA-templated transcription, initiation
DA116_RS15100	COG2072	flavoprotein involved in K transport
DA116_RS15105	COG1231	oxidoreductase activity
DA116_RS15115	COG1024	Enoyl-CoA hydratase
DA116_RS15145	COG1960	acyl-CoA dehydrogenase activity
DA116_RS15150	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS15170	COG1960	acyl-CoA dehydrogenase activity
DA116_RS15175	COG1960	acyl-CoA dehydrogenase activity
DA116_RS15195	COG1595	DNA-templated transcription, initiation
DA116_RS15240	COG1131	(ABC) transporter
DA116_RS15250	COG0596	Alpha beta hydrolase
DA116_RS15250	COG2945	thiolester hydrolase activity
DA116_RS15260	COG4821	SIS domain
DA116_RS15280	COG0583	DNA-binding transcription factor activity
DA116_RS15290	COG0259	pyridoxamine-phosphate oxidase activity
DA116_RS15310	COG1024	Enoyl-CoA hydratase
DA116_RS15315	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS15330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA116_RS15350	COG5006	permease, DMT superfamily
DA116_RS15360	COG0277	FAD linked oxidase domain protein
DA116_RS15360	COG0247	lactate metabolic process
DA116_RS15365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DA116_RS15370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DA116_RS15415	COG0667	Aldo Keto reductase
DA116_RS15445	COG2252	PERMEase
DA116_RS15455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA116_RS15510	COG2814	Major facilitator Superfamily
DA116_RS15520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA116_RS15525	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DA116_RS15530	COG1278	Cold shock
DA116_RS15550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA116_RS15570	COG1061	Type III restriction enzyme res subunit
DA116_RS15580	COG3973	AAA domain
DA116_RS15630	COG1737	Transcriptional regulator
DA116_RS15635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DA116_RS15640	COG0667	Aldo Keto reductase
DA116_RS15660	COG2318	DinB family
DA116_RS15685	COG0459	protein refolding
DA116_RS15705	COG0463	Glycosyl transferase, family 2
DA116_RS15710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DA116_RS15735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA116_RS15740	COG1105	Belongs to the carbohydrate kinase PfkB family
DA116_RS15750	COG5001	Diguanylate cyclase
DA116_RS15750	COG3300	MHYT domain
DA116_RS15770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA116_RS15860	COG3629	intracellular signal transduction
DA116_RS15860	COG3903	Transcriptional regulator
DA116_RS15890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS15895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS15955	COG3842	ATPase activity
DA116_RS15975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA116_RS15980	COG0215	cysteine-tRNA ligase activity
DA116_RS15985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DA116_RS15990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DA116_RS15995	COG1329	Transcriptional regulator
DA116_RS16015	COG5002	protein histidine kinase activity
DA116_RS16040	COG0222	ribosome binding
DA116_RS16050	COG0588	phosphoglycerate mutase activity
DA116_RS16080	COG0438	transferase activity, transferring glycosyl groups
DA116_RS16115	COG2267	carboxylic ester hydrolase activity
DA116_RS16120	COG1090	epimerase
DA116_RS16125	COG1733	regulation of RNA biosynthetic process
DA116_RS16145	COG3973	AAA domain
DA116_RS16180	COG2188	Transcriptional regulator
DA116_RS16190	COG2186	Transcriptional regulator
DA116_RS16200	COG4552	Acetyltransferase involved in intracellular survival and related
DA116_RS16210	COG1490	D-aminoacyl-tRNA deacylase activity
DA116_RS16220	COG0354	folic acid binding
DA116_RS16270	COG2897	thiosulfate sulfurtransferase activity
DA116_RS16300	COG0745	RESPONSE REGULATOR receiver
DA116_RS16305	COG1609	Transcriptional regulator
DA116_RS16310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA116_RS16320	COG0745	RESPONSE REGULATOR receiver
DA116_RS16370	COG1132	(ABC) transporter
DA116_RS16380	COG0737	Belongs to the 5'-nucleotidase family
DA116_RS16385	COG0456	acetyltransferase
DA116_RS16390	COG1725	Transcriptional regulator
DA116_RS16420	COG0406	alpha-ribazole phosphatase activity
DA116_RS16420	COG0494	nUDIX hydrolase
DA116_RS16435	COG0581	inorganic phosphate transmembrane transporter activity
DA116_RS16440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA116_RS16455	COG1937	Protein conserved in bacteria
DA116_RS16465	COG0306	phosphate transporter
DA116_RS16475	COG0277	FAD linked oxidase domain protein
DA116_RS16480	COG0671	phosphoesterase, PA-phosphatase related
DA116_RS16485	COG0739	heme binding
DA116_RS16485	COG1196	nuclear chromosome segregation
DA116_RS16485	COG0741	lytic transglycosylase activity
DA116_RS16500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA116_RS16525	COG1846	Transcriptional regulator
DA116_RS16590	COG2188	Transcriptional regulator
DA116_RS16595	COG2182	Extracellular solute-binding protein
DA116_RS16600	COG1175	transmembrane transport
DA116_RS16605	COG0395	ABC-type sugar transport system, permease component
DA116_RS16630	COG1131	(ABC) transporter
DA116_RS16640	COG4585	Histidine kinase
DA116_RS16670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA116_RS16690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DA116_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS16735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DA116_RS16740	COG3119	arylsulfatase activity
DA116_RS16795	COG2271	Major facilitator Superfamily
DA116_RS16805	COG0071	Belongs to the small heat shock protein (HSP20) family
DA116_RS16810	COG3634	alkyl hydroperoxide reductase activity
DA116_RS16825	COG0542	response to heat
DA116_RS16840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DA116_RS16845	COG0443	Heat shock 70 kDa protein
DA116_RS16855	COG3835	regulator
DA116_RS16860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DA116_RS16990	COG0596	Alpha beta hydrolase
DA116_RS17070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA116_RS17090	COG0395	ABC-type sugar transport system, permease component
DA116_RS17100	COG1191	sigma factor activity
DA116_RS17120	COG0604	alcohol dehydrogenase
DA116_RS17230	COG0667	Aldo Keto reductase
DA116_RS17255	COG2124	cytochrome p450
DA116_RS17280	COG0435	Glutathione S-transferase
DA116_RS17305	COG0531	amino acid
DA116_RS17345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA116_RS17355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA116_RS17360	COG1006	Multisubunit Na H antiporter MnhC subunit
DA116_RS17405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA116_RS17405	COG1796	DNA polymerase
DA116_RS17465	COG2706	6-phosphogluconolactonase activity
DA116_RS17475	COG1309	transcriptional regulator
DA116_RS17485	COG1357	PFAM Pentapeptide repeats (8 copies)
DA116_RS17495	COG1595	DNA-templated transcription, initiation
DA116_RS17510	COG1609	Transcriptional regulator
DA116_RS17535	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA116_RS17540	COG1129	ABC transporter
DA116_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS17550	COG3347	Dehydrogenase
DA116_RS17555	COG1070	Carbohydrate kinase
DA116_RS17560	COG0247	lactate metabolic process
DA116_RS17565	COG1139	Iron-sulfur cluster binding protein
DA116_RS17570	COG1556	Lactate utilization protein
DA116_RS17575	COG3250	beta-galactosidase activity
DA116_RS17590	COG1136	(ABC) transporter
DA116_RS17590	COG0577	efflux transmembrane transporter activity
DA116_RS17605	COG0542	response to heat
DA116_RS17655	COG1609	Transcriptional regulator
DA116_RS17670	COG1121	(ABC) transporter
DA116_RS17680	COG2135	peptidase activity
DA116_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS17745	COG1088	dTDP-glucose 4,6-dehydratase activity
DA116_RS17770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS17775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS17855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DA116_RS17865	COG0584	glycerophosphoryl diester phosphodiesterase
DA116_RS17885	COG1349	DNA-binding transcription factor activity
DA116_RS17895	COG0395	ABC-type sugar transport system, permease component
DA116_RS17900	COG1175	transmembrane transport
DA116_RS17905	COG1653	transport
DA116_RS17910	COG1070	Carbohydrate kinase
DA116_RS17915	COG0588	phosphoglycerate mutase activity
DA116_RS17930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA116_RS17935	COG1113	amino acid transport
DA116_RS17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS17950	COG1116	anion transmembrane transporter activity
DA116_RS17955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS17970	COG1268	BioY protein
DA116_RS17990	COG1113	amino acid transport
DA116_RS17995	COG0698	ribose 5-phosphate isomerase
DA116_RS18005	COG4552	Acetyltransferase involved in intracellular survival and related
DA116_RS18020	COG3594	Acyltransferase
DA116_RS18030	COG0515	serine threonine protein kinase
DA116_RS18030	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS18035	COG0509	glycine decarboxylation via glycine cleavage system
DA116_RS18050	COG0544	peptidyl-prolyl cis-trans isomerase activity
DA116_RS18055	COG0740	serine-type endopeptidase activity
DA116_RS18060	COG0740	serine-type endopeptidase activity
DA116_RS18065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DA116_RS18080	COG0525	valine-tRNA ligase activity
DA116_RS18085	COG0285	dihydrofolate synthase activity
DA116_RS18095	COG0105	UTP biosynthetic process
DA116_RS18100	COG1077	Cell shape determining protein MreB Mrl
DA116_RS18120	COG0772	Belongs to the SEDS family
DA116_RS18145	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DA116_RS18205	COG0076	glutamate decarboxylase activity
DA116_RS18210	COG1252	NADH dehydrogenase
DA116_RS18215	COG1595	DNA-templated transcription, initiation
DA116_RS18225	COG0477	Major facilitator Superfamily
DA116_RS18245	COG2326	polyphosphate kinase activity
DA116_RS18250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA116_RS18275	COG1530	ribonuclease E activity
DA116_RS18280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DA116_RS18285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DA116_RS18305	COG3540	Alkaline phosphatase
DA116_RS18325	COG1215	transferase activity, transferring glycosyl groups
DA116_RS18335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA116_RS18360	COG0501	Belongs to the peptidase M48B family
DA116_RS18365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DA116_RS18375	COG0799	negative regulation of ribosome biogenesis
DA116_RS18380	COG0588	phosphoglycerate mutase activity
DA116_RS18405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DA116_RS18420	COG0495	leucyl-tRNA aminoacylation
DA116_RS18430	COG1307	EDD domain protein, DegV family
DA116_RS18435	COG1555	photosystem II stabilization
DA116_RS18435	COG1596	polysaccharide export
DA116_RS18440	COG1234	tRNA 3'-trailer cleavage
DA116_RS18470	COG0268	Binds directly to 16S ribosomal RNA
DA116_RS18475	COG0481	GTPase activity
DA116_RS18515	COG1420	regulation of RNA biosynthetic process
DA116_RS18520	COG0484	heat shock protein binding
DA116_RS18550	COG4946	Tricorn protease homolog
DA116_RS18550	COG0793	Belongs to the peptidase S41A family
DA116_RS18555	COG0537	adenosine 5'-monophosphoramidase activity
DA116_RS18560	COG1234	tRNA 3'-trailer cleavage
DA116_RS18565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA116_RS18580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS18585	COG4948	Mandelate Racemase Muconate Lactonizing
DA116_RS18590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS18620	COG2315	Protein conserved in bacteria
DA116_RS18630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DA116_RS18640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DA116_RS18680	COG2723	6-phospho-beta-galactosidase activity
DA116_RS18700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA116_RS18710	COG2409	Drug exporters of the RND superfamily
DA116_RS18715	COG4585	Histidine kinase
DA116_RS18720	COG2197	response regulator
DA116_RS18730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS18735	COG4608	Belongs to the ABC transporter superfamily
DA116_RS18740	COG0444	Belongs to the ABC transporter superfamily
DA116_RS18755	COG2186	Transcriptional regulator
DA116_RS18770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA116_RS18805	COG0456	acetyltransferase
DA116_RS18865	COG1381	Involved in DNA repair and RecF pathway recombination
DA116_RS18870	COG1381	Involved in DNA repair and RecF pathway recombination
DA116_RS18875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA116_RS18890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA116_RS18895	COG1121	(ABC) transporter
DA116_RS18900	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA116_RS18900	COG3443	Belongs to the bacterial solute-binding protein 9 family
DA116_RS18905	COG0423	glycine-tRNA ligase activity
DA116_RS18920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA116_RS18920	COG0116	Belongs to the methyltransferase superfamily
DA116_RS18950	COG0456	acetyltransferase
DA116_RS18960	COG0477	Major facilitator Superfamily
DA116_RS18990	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DA116_RS18995	COG1846	Transcriptional regulator
DA116_RS18995	COG1940	carbohydrate kinase activity
DA116_RS19000	COG0574	Belongs to the PEP-utilizing enzyme family
DA116_RS19000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA116_RS19070	COG0659	secondary active sulfate transmembrane transporter activity
DA116_RS19085	COG1309	transcriptional regulator
DA116_RS19095	COG2146	nitrite reductase [NAD(P)H] activity
DA116_RS19095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA116_RS19100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA116_RS19115	COG2197	response regulator
DA116_RS19130	COG1733	regulation of RNA biosynthetic process
DA116_RS19160	COG0243	molybdopterin cofactor binding
DA116_RS19165	COG2949	membrane
DA116_RS19175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DA116_RS19185	COG0358	DNA primase activity
DA116_RS19190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA116_RS19205	COG1070	Carbohydrate kinase
DA116_RS19230	COG3263	regulation of cellular component size
DA116_RS19240	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS19255	COG1294	oxidase, subunit
DA116_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS19280	COG0589	response to stress
DA116_RS19300	COG3290	protein histidine kinase activity
DA116_RS19305	COG4565	transcriptional regulatory protein
DA116_RS19320	COG1077	Cell shape determining protein MreB Mrl
DA116_RS19330	COG2815	serine threonine protein kinase
DA116_RS19330	COG0515	serine threonine protein kinase
DA116_RS19345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DA116_RS19345	COG0825	malonyl-CoA metabolic process
DA116_RS19350	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS19360	COG2186	Transcriptional regulator
DA116_RS19390	COG2835	tetraacyldisaccharide 4'-kinase activity
DA116_RS19390	COG1663	tetraacyldisaccharide 4'-kinase activity
DA116_RS19455	COG1414	Transcriptional regulator
DA116_RS19460	COG3386	PFAM SMP-30 Gluconolaconase
DA116_RS19505	COG1175	transmembrane transport
DA116_RS19510	COG0395	ABC-type sugar transport system, permease component
DA116_RS19520	COG0730	response to heat
DA116_RS19550	COG3507	Belongs to the glycosyl hydrolase 43 family
DA116_RS19555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA116_RS19570	COG1129	ABC transporter
DA116_RS19605	COG1597	lipid kinase activity
DA116_RS19615	COG2130	NADP-dependent
DA116_RS19620	COG1764	response to oxidative stress
DA116_RS19650	COG0583	DNA-binding transcription factor activity
DA116_RS19660	COG1309	transcriptional regulator
DA116_RS19685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS19690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS19695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS19715	COG2409	Drug exporters of the RND superfamily
DA116_RS19730	COG0789	Transcriptional regulator
DA116_RS19735	COG0667	Aldo Keto reductase
DA116_RS19750	COG1309	transcriptional regulator
DA116_RS19770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DA116_RS19830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA116_RS19875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA116_RS19955	COG4122	O-methyltransferase activity
DA116_RS20005	COG3033	Beta-eliminating lyase
DA116_RS20025	COG0183	Belongs to the thiolase family
DA116_RS20030	COG2124	cytochrome p450
DA116_RS20045	COG3845	ABC transporter
DA116_RS20060	COG1657	PFAM Prenyltransferase squalene oxidase
DA116_RS20090	COG1309	transcriptional regulator
DA116_RS20095	COG0438	transferase activity, transferring glycosyl groups
DA116_RS20130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS20165	COG0477	Major facilitator Superfamily
DA116_RS20185	COG2197	response regulator
DA116_RS20200	COG2030	dehydratase
DA116_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS20220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DA116_RS20235	COG0800	Aldolase
DA116_RS20240	COG3022	response to hydroperoxide
DA116_RS20285	COG0424	maF-like protein
DA116_RS20330	COG0443	Heat shock 70 kDa protein
DA116_RS20375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DA116_RS20385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA116_RS20390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS20390	COG0515	serine threonine protein kinase
DA116_RS20435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA116_RS20465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA116_RS20490	COG0745	RESPONSE REGULATOR receiver
DA116_RS20495	COG2072	flavoprotein involved in K transport
DA116_RS20510	COG2259	Doxx family
DA116_RS20520	COG0667	Aldo Keto reductase
DA116_RS20525	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS20530	COG3540	Alkaline phosphatase
DA116_RS20540	COG2814	Major facilitator Superfamily
DA116_RS20545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS20575	COG0672	)-iron permease
DA116_RS20580	COG2837	iron assimilation
DA116_RS20590	COG1120	ATPase activity
DA116_RS20595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS20600	COG4558	Periplasmic binding protein
DA116_RS20665	COG1994	Peptidase M50
DA116_RS20690	COG2814	Major facilitator Superfamily
DA116_RS20705	COG0477	Major facilitator Superfamily
DA116_RS20710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DA116_RS20730	COG1959	2 iron, 2 sulfur cluster binding
DA116_RS20735	COG1017	nitric oxide dioxygenase activity
DA116_RS20735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA116_RS20790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DA116_RS20810	COG1175	transmembrane transport
DA116_RS20815	COG3833	ABC-type maltose transport systems, permease component
DA116_RS20885	COG2197	response regulator
DA116_RS20890	COG4585	Histidine kinase
DA116_RS20900	COG0745	RESPONSE REGULATOR receiver
DA116_RS20955	COG0501	Belongs to the peptidase M48B family
DA116_RS20965	COG0174	glutamine synthetase
DA116_RS20985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DA116_RS20990	COG0321	lipoyl(octanoyl) transferase activity
DA116_RS21005	COG1090	epimerase
DA116_RS21010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS21045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DA116_RS21055	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA116_RS21060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA116_RS21065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA116_RS21105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DA116_RS21125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA116_RS21150	COG4585	Histidine kinase
DA116_RS21155	COG2197	response regulator
DA116_RS21160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA116_RS21175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DA116_RS21195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS21205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA116_RS21210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA116_RS21220	COG1376	ErfK ybiS ycfS ynhG family protein
DA116_RS21230	COG1845	cytochrome c oxidase, subunit III
DA116_RS21235	COG2010	Cytochrome c
DA116_RS21240	COG0723	plastoquinol--plastocyanin reductase activity
DA116_RS21245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA116_RS21250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DA116_RS21255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA116_RS21260	COG1929	Belongs to the glycerate kinase type-1 family
DA116_RS21275	COG2205	protein histidine kinase activity
DA116_RS21355	COG1940	carbohydrate kinase activity
DA116_RS21380	COG4585	Histidine kinase
DA116_RS21390	COG0205	6-phosphofructokinase activity
DA116_RS21395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA116_RS21410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DA116_RS21415	COG0243	molybdopterin cofactor binding
DA116_RS21420	COG2193	ferroxidase activity
DA116_RS21425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA116_RS21435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DA116_RS21440	COG0515	serine threonine protein kinase
DA116_RS21440	COG2815	serine threonine protein kinase
DA116_RS21445	COG2022	thiamine diphosphate biosynthetic process
DA116_RS21455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS21455	COG2022	thiamine diphosphate biosynthetic process
DA116_RS21475	COG0352	thiamine-phosphate diphosphorylase activity
DA116_RS21500	COG1309	transcriptional regulator
DA116_RS21510	COG3842	ATPase activity
DA116_RS21520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA116_RS21540	COG0714	Associated with various cellular activities
DA116_RS21565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA116_RS21575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA116_RS21580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DA116_RS21590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA116_RS21595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA116_RS21600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA116_RS21605	COG1496	oxidoreductase activity
DA116_RS21630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA116_RS21640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DA116_RS21705	COG1432	Conserved Protein
DA116_RS21725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DA116_RS21730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA116_RS21745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DA116_RS21750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA116_RS21755	COG0131	Imidazoleglycerol-phosphate dehydratase
DA116_RS21760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DA116_RS21765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DA116_RS21770	COG0251	oxidation-reduction process
DA116_RS21775	COG0107	imidazoleglycerol-phosphate synthase activity
DA116_RS21795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DA116_RS21800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA116_RS21820	COG0134	indole-3-glycerol-phosphate synthase activity
DA116_RS21830	COG0133	tryptophan synthase activity
DA116_RS21835	COG0159	tryptophan synthase activity
DA116_RS21845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DA116_RS21855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DA116_RS21860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS21890	COG0067	glutamate synthase
DA116_RS21890	COG0070	glutamate synthase
DA116_RS21890	COG0069	glutamate synthase activity
DA116_RS21910	COG2304	oxidoreductase activity
DA116_RS21915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA116_RS21925	COG1960	acyl-CoA dehydrogenase activity
DA116_RS21930	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS21935	COG1309	transcriptional regulator
DA116_RS21940	COG0183	Belongs to the thiolase family
DA116_RS21945	COG2070	2-Nitropropane dioxygenase
DA116_RS21960	COG1024	Enoyl-CoA hydratase
DA116_RS21980	COG5640	endopeptidase activity
DA116_RS21995	COG0287	Prephenate dehydrogenase
DA116_RS21995	COG1605	Chorismate mutase
DA116_RS22000	COG0745	RESPONSE REGULATOR receiver
DA116_RS22030	COG0737	Belongs to the 5'-nucleotidase family
DA116_RS22060	COG0411	ABC transporter
DA116_RS22085	COG2050	protein possibly involved in aromatic compounds catabolism
DA116_RS22150	COG0237	dephospho-CoA kinase activity
DA116_RS22185	COG2267	carboxylic ester hydrolase activity
DA116_RS22190	COG1802	Transcriptional regulator
DA116_RS22205	COG0456	acetyltransferase
DA116_RS22240	COG0402	S-adenosylhomocysteine deaminase activity
DA116_RS22245	COG2124	cytochrome p450
DA116_RS22290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA116_RS22295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS22330	COG0598	Magnesium transport protein CorA
DA116_RS22335	COG2226	methyltransferase
DA116_RS22340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DA116_RS22340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DA116_RS22345	COG2313	pseudouridylate synthase activity
DA116_RS22365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA116_RS22370	COG0584	glycerophosphoryl diester phosphodiesterase
DA116_RS22405	COG0387	Pfam Sodium calcium exchanger
DA116_RS22410	COG0477	Major facilitator Superfamily
DA116_RS22415	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA116_RS22420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DA116_RS22425	COG1126	abc transporter atp-binding protein
DA116_RS22430	COG0765	amino acid transport
DA116_RS22435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA116_RS22450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA116_RS22460	COG1609	Transcriptional regulator
DA116_RS22480	COG1660	Displays ATPase and GTPase activities
DA116_RS22485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA116_RS22490	COG1481	regulation of sporulation
DA116_RS22500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA116_RS22505	COG0126	phosphoglycerate kinase activity
DA116_RS22510	COG0149	triose-phosphate isomerase activity
DA116_RS22515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA116_RS22530	COG0166	Belongs to the GPI family
DA116_RS22545	COG1136	(ABC) transporter
DA116_RS22550	COG1695	Transcriptional regulator
DA116_RS22555	COG1653	transport
DA116_RS22560	COG0366	Alpha amylase catalytic
DA116_RS22565	COG1653	transport
DA116_RS22570	COG1175	transmembrane transport
DA116_RS22575	COG0395	ABC-type sugar transport system, permease component
DA116_RS22580	COG0363	glucosamine-6-phosphate deaminase activity
DA116_RS22595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA116_RS22610	COG0109	protoheme IX farnesyltransferase activity
DA116_RS22625	COG1612	heme a metabolic process
DA116_RS22635	COG1131	(ABC) transporter
DA116_RS22640	COG2746	aminoglycoside 3-N-acetyltransferase activity
DA116_RS22655	COG0719	Fe-S assembly protein
DA116_RS22665	COG0396	ATPase activity
DA116_RS22670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA116_RS22675	COG0822	iron-sulfur transferase activity
DA116_RS22680	COG2151	metal-sulfur cluster biosynthetic enzyme
DA116_RS22690	COG0583	DNA-binding transcription factor activity
DA116_RS22710	COG1733	regulation of RNA biosynthetic process
DA116_RS22715	COG2076	Multidrug Resistance protein
DA116_RS22720	COG3226	Transcriptional regulator
DA116_RS22735	COG2171	N-acyltransferase activity
DA116_RS22745	COG1595	DNA-templated transcription, initiation
DA116_RS22815	COG1802	Transcriptional regulator
DA116_RS22825	COG1609	Transcriptional regulator
DA116_RS22835	COG1063	alcohol dehydrogenase
DA116_RS22860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA116_RS22865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS22890	COG1802	Transcriptional regulator
DA116_RS22895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS22905	COG1175	transmembrane transport
DA116_RS22910	COG0395	ABC-type sugar transport system, permease component
DA116_RS22970	COG5297	Belongs to the glycosyl hydrolase family 6
DA116_RS22985	COG2252	PERMEase
DA116_RS22990	COG0768	penicillin binding
DA116_RS22995	COG2197	response regulator
DA116_RS23015	COG1414	Transcriptional regulator
DA116_RS23025	COG2197	response regulator
DA116_RS23030	COG4585	Histidine kinase
DA116_RS23050	COG4977	sequence-specific DNA binding
DA116_RS23050	COG1917	Cupin 2, conserved barrel domain protein
DA116_RS23065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA116_RS23080	COG5285	phytanoyl-CoA dioxygenase
DA116_RS23085	COG1917	Cupin 2, conserved barrel domain protein
DA116_RS23090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA116_RS23095	COG0456	acetyltransferase
DA116_RS23100	COG2318	DinB family
DA116_RS23105	COG1104	cysteine desulfurase activity
DA116_RS23115	COG0765	amino acid transport
DA116_RS23170	COG1797	cobyrinic acid a,c-diamide synthase activity
DA116_RS23190	COG1492	cobalamin metabolic process
DA116_RS23195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DA116_RS23240	COG0488	(ABC) transporter
DA116_RS23290	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS23315	COG1966	Carbon starvation protein
DA116_RS23330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA116_RS23350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DA116_RS23365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA116_RS23370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DA116_RS23390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DA116_RS23400	COG0312	modulator of DNA gyrase
DA116_RS23405	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS23420	COG2186	Transcriptional regulator
DA116_RS23425	COG2807	transmembrane transport
DA116_RS23440	COG0588	phosphoglycerate mutase activity
DA116_RS23445	COG0560	Phosphoserine phosphatase
DA116_RS23445	COG3830	Belongs to the UPF0237 family
DA116_RS23465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DA116_RS23470	COG4221	oxidoreductase activity
DA116_RS23480	COG2197	response regulator
DA116_RS23495	COG1119	ATPase activity
DA116_RS23515	COG1881	PFAM PEBP family protein
DA116_RS23525	COG2094	Belongs to the DNA glycosylase MPG family
DA116_RS23565	COG2770	Histidine kinase
DA116_RS23565	COG2208	phosphoserine phosphatase activity
DA116_RS23575	COG2205	protein histidine kinase activity
DA116_RS23575	COG3437	response regulator, receiver
DA116_RS23575	COG3850	Histidine kinase
DA116_RS23575	COG4999	Histidine kinase
DA116_RS23585	COG1674	ftsk spoiiie
DA116_RS23595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA116_RS23605	COG1058	Belongs to the CinA family
DA116_RS23605	COG1546	Belongs to the CinA family
DA116_RS23610	COG1396	sequence-specific DNA binding
DA116_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS23625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA116_RS23635	COG1917	Cupin 2, conserved barrel domain protein
DA116_RS23635	COG2207	Transcriptional regulator
DA116_RS23660	COG0628	permease
DA116_RS23670	COG1396	sequence-specific DNA binding
DA116_RS23705	COG0765	amino acid transport
DA116_RS23710	COG0765	amino acid transport
DA116_RS23715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA116_RS23720	COG1126	abc transporter atp-binding protein
DA116_RS23725	COG0745	RESPONSE REGULATOR receiver
DA116_RS23730	COG2205	protein histidine kinase activity
DA116_RS23735	COG2358	TRAP transporter, solute receptor (TAXI family
DA116_RS23745	COG0604	alcohol dehydrogenase
DA116_RS23745	COG3321	synthase
DA116_RS23745	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS23755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA116_RS23765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA116_RS23790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DA116_RS23800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DA116_RS23820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA116_RS23855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA116_RS23860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DA116_RS23865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA116_RS23880	COG0588	phosphoglycerate mutase activity
DA116_RS23900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DA116_RS23940	COG1802	Transcriptional regulator
DA116_RS23945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA116_RS23960	COG0187	DNA topoisomerase II activity
DA116_RS23975	COG4565	transcriptional regulatory protein
DA116_RS24000	COG0523	cobalamin synthesis protein
DA116_RS24005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA116_RS24010	COG0612	Peptidase, M16
DA116_RS24025	COG1802	Transcriptional regulator
DA116_RS24030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA116_RS24055	COG1435	thymidine kinase activity
DA116_RS24085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DA116_RS24095	COG0745	RESPONSE REGULATOR receiver
DA116_RS24100	COG2205	protein histidine kinase activity
DA116_RS24125	COG0756	dUTP diphosphatase activity
DA116_RS24165	COG0569	domain protein
DA116_RS24170	COG0531	amino acid
DA116_RS24175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA116_RS24195	COG1595	DNA-templated transcription, initiation
DA116_RS24215	COG0656	L-ascorbic acid biosynthetic process
DA116_RS24225	COG0667	Aldo Keto reductase
DA116_RS24250	COG1215	transferase activity, transferring glycosyl groups
DA116_RS24260	COG4310	Domain of unknown function (DUF2172)
DA116_RS24275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA116_RS24285	COG0438	transferase activity, transferring glycosyl groups
DA116_RS24310	COG0367	asparagine synthase
DA116_RS24330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA116_RS24345	COG1733	regulation of RNA biosynthetic process
DA116_RS24350	COG1414	Transcriptional regulator
DA116_RS24365	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS24395	COG3629	intracellular signal transduction
DA116_RS24395	COG3903	Transcriptional regulator
DA116_RS24420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA116_RS24460	COG2084	Dehydrogenase
DA116_RS24475	COG0604	alcohol dehydrogenase
DA116_RS24475	COG3321	synthase
DA116_RS24475	COG3321	synthase
DA116_RS24475	COG0604	alcohol dehydrogenase
DA116_RS24495	COG4221	oxidoreductase activity
DA116_RS24505	COG1181	Belongs to the D-alanine--D-alanine ligase family
DA116_RS24510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS24520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA116_RS24530	COG0426	domain, Protein
DA116_RS24530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA116_RS24580	COG1140	nitrate reductase beta subunit
DA116_RS24595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA116_RS24615	COG0243	molybdopterin cofactor binding
DA116_RS24620	COG1799	cell septum assembly
DA116_RS24625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA116_RS24655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DA116_RS24670	COG2235	arginine
DA116_RS24675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DA116_RS24685	COG1024	Enoyl-CoA hydratase
DA116_RS24705	COG0529	Catalyzes the synthesis of activated sulfate
DA116_RS24740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA116_RS24745	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DA116_RS24750	COG3971	2-oxopent-4-enoate hydratase activity
DA116_RS24755	COG1414	Transcriptional regulator
DA116_RS24775	COG2267	carboxylic ester hydrolase activity
DA116_RS24790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DA116_RS24825	COG3408	Glycogen debranching enzyme
DA116_RS24825	COG3119	arylsulfatase activity
DA116_RS24830	COG2205	protein histidine kinase activity
DA116_RS24835	COG2207	Transcriptional regulator
DA116_RS24865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA116_RS24875	COG0137	argininosuccinate synthase activity
DA116_RS24885	COG2205	protein histidine kinase activity
DA116_RS24925	COG3537	Alpha-1,2-mannosidase
DA116_RS24935	COG1653	transport
DA116_RS24940	COG1175	transmembrane transport
DA116_RS24945	COG0395	ABC-type sugar transport system, permease component
DA116_RS24950	COG1940	carbohydrate kinase activity
DA116_RS24965	COG4214	carbohydrate transport
DA116_RS24975	COG0531	amino acid
DA116_RS25010	COG1024	Enoyl-CoA hydratase
DA116_RS25010	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA116_RS25015	COG0183	Belongs to the thiolase family
DA116_RS25020	COG1609	Transcriptional regulator
DA116_RS25025	COG3250	beta-galactosidase activity
DA116_RS25035	COG1175	transmembrane transport
DA116_RS25040	COG3833	ABC-type maltose transport systems, permease component
DA116_RS25045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DA116_RS25060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DA116_RS25075	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA116_RS25085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DA116_RS25090	COG3253	May function as heme-dependent peroxidase
DA116_RS25120	COG1121	(ABC) transporter
DA116_RS25150	COG0330	HflC and HflK could
DA116_RS25190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA116_RS25195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA116_RS25210	COG1472	Belongs to the glycosyl hydrolase 3 family
DA116_RS25220	COG1737	Transcriptional regulator
DA116_RS25225	COG4821	SIS domain
DA116_RS25240	COG0596	Alpha beta hydrolase
DA116_RS25245	COG1073	alpha beta
DA116_RS25255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA116_RS25260	COG3284	Transcriptional regulator
DA116_RS25280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA116_RS25300	COG0747	negative chemotaxis
DA116_RS25310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS25315	COG4172	Belongs to the ABC transporter superfamily
DA116_RS25365	COG0745	RESPONSE REGULATOR receiver
DA116_RS25370	COG5002	protein histidine kinase activity
DA116_RS25380	COG5002	protein histidine kinase activity
DA116_RS25385	COG0745	RESPONSE REGULATOR receiver
DA116_RS25420	COG1174	glycine betaine transport
DA116_RS25440	COG2018	Roadblock/LC7 domain
DA116_RS25460	COG1940	carbohydrate kinase activity
DA116_RS25460	COG1846	Transcriptional regulator
DA116_RS25545	COG1404	Belongs to the peptidase S8 family
DA116_RS25575	COG2358	TRAP transporter, solute receptor (TAXI family
DA116_RS25590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA116_RS25590	COG1116	anion transmembrane transporter activity
DA116_RS25615	COG0504	CTP synthase activity
DA116_RS25625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA116_RS25630	COG1280	lysine exporter protein (LysE YggA)
DA116_RS25715	COG0583	DNA-binding transcription factor activity
DA116_RS25725	COG1175	transmembrane transport
DA116_RS25740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA116_RS25790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS25795	COG1116	anion transmembrane transporter activity
DA116_RS25820	COG0529	Catalyzes the synthesis of activated sulfate
DA116_RS25825	COG0175	sulfate reduction
DA116_RS25855	COG1960	acyl-CoA dehydrogenase activity
DA116_RS25870	COG1917	Cupin 2, conserved barrel domain protein
DA116_RS25870	COG4977	sequence-specific DNA binding
DA116_RS25900	COG3903	Transcriptional regulator
DA116_RS25900	COG3629	intracellular signal transduction
DA116_RS25920	COG2040	homocysteine
DA116_RS25940	COG2755	lipolytic protein G-D-S-L family
DA116_RS25960	COG0494	nUDIX hydrolase
DA116_RS25985	COG4585	Histidine kinase
DA116_RS25990	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA116_RS25990	COG1136	(ABC) transporter
DA116_RS26045	COG1131	(ABC) transporter
DA116_RS26060	COG1175	transmembrane transport
DA116_RS26080	COG0277	FAD linked oxidase domain protein
DA116_RS26100	COG1162	GTPase activity
DA116_RS26110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA116_RS26170	COG1802	Transcriptional regulator
DA116_RS26185	COG3835	regulator
DA116_RS26205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DA116_RS26210	COG2252	PERMEase
DA116_RS26230	COG5634	Uncharacterized conserved protein (DUF2278)
DA116_RS26240	COG3940	Belongs to the glycosyl hydrolase 43 family
DA116_RS26245	COG3940	Belongs to the glycosyl hydrolase 43 family
DA116_RS26250	COG4172	Belongs to the ABC transporter superfamily
DA116_RS26260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS26285	COG3290	protein histidine kinase activity
DA116_RS26310	COG0583	DNA-binding transcription factor activity
DA116_RS26380	COG0598	Magnesium transport protein CorA
DA116_RS26405	COG2197	response regulator
DA116_RS26410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA116_RS26415	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS26430	COG3960	tartronate-semialdehyde synthase activity
DA116_RS26440	COG0753	catalase activity
DA116_RS26445	COG2084	Dehydrogenase
DA116_RS26450	COG3622	Belongs to the hyi family
DA116_RS26465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DA116_RS26465	COG1024	Enoyl-CoA hydratase
DA116_RS26475	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DA116_RS26505	COG0375	protein maturation
DA116_RS26510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DA116_RS26520	COG0298	carbon dioxide binding
DA116_RS26530	COG0309	Hydrogenase expression formation protein (HypE)
DA116_RS26550	COG2351	hydroxyisourate hydrolase activity
DA116_RS26565	COG2233	PERMEase
DA116_RS26575	COG0515	serine threonine protein kinase
DA116_RS26575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS26585	COG0702	epimerase
DA116_RS26595	COG1733	regulation of RNA biosynthetic process
DA116_RS26610	COG0406	alpha-ribazole phosphatase activity
DA116_RS26620	COG0436	Aminotransferase
DA116_RS26640	COG4264	IucA IucC family
DA116_RS26665	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DA116_RS26680	COG1414	Transcriptional regulator
DA116_RS26685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA116_RS26690	COG4266	Belongs to the allantoicase family
DA116_RS26695	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS26730	COG2197	response regulator
DA116_RS26740	COG0673	inositol 2-dehydrogenase activity
DA116_RS26745	COG2188	Transcriptional regulator
DA116_RS26750	COG1940	carbohydrate kinase activity
DA116_RS26760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA116_RS26775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS26800	COG2936	dipeptidyl-peptidase activity
DA116_RS26810	COG0405	Gamma-glutamyltransferase
DA116_RS26815	COG0542	response to heat
DA116_RS26820	COG1132	(ABC) transporter
DA116_RS26865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA116_RS26880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA116_RS26905	COG3851	Histidine kinase
DA116_RS26910	COG2197	response regulator
DA116_RS26945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA116_RS26955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DA116_RS26980	COG0483	inositol monophosphate 1-phosphatase activity
DA116_RS27035	COG2318	DinB family
DA116_RS27100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA116_RS27125	COG0640	Transcriptional regulator
DA116_RS27165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DA116_RS27180	COG1929	Belongs to the glycerate kinase type-1 family
DA116_RS27190	COG0688	phosphatidylethanolamine metabolic process
DA116_RS27210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS27210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA116_RS27215	COG0604	alcohol dehydrogenase
DA116_RS27230	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA116_RS27250	COG0596	Alpha beta hydrolase
DA116_RS27270	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS27270	COG2172	sigma factor antagonist activity
DA116_RS27270	COG2208	phosphoserine phosphatase activity
DA116_RS27275	COG2226	methyltransferase
DA116_RS27280	COG5297	Belongs to the glycosyl hydrolase family 6
DA116_RS27280	COG3250	beta-galactosidase activity
DA116_RS27305	COG1122	ATPase activity
DA116_RS27320	COG0310	cobalt ion transport
DA116_RS27330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS27335	COG0823	Involved in the tonB-independent uptake of proteins
DA116_RS27335	COG1506	peptidase
DA116_RS27335	COG4946	Tricorn protease homolog
DA116_RS27340	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA116_RS27375	COG4948	Mandelate Racemase Muconate Lactonizing
DA116_RS27390	COG1793	dna ligase
DA116_RS27390	COG3285	dna ligase
DA116_RS27465	COG0488	(ABC) transporter
DA116_RS27490	COG1846	Transcriptional regulator
DA116_RS27505	COG0028	Belongs to the TPP enzyme family
DA116_RS27595	COG1140	nitrate reductase beta subunit
DA116_RS27630	COG2154	pterin-4-alpha-carbinolamine dehydratase
DA116_RS27635	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS27635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DA116_RS27640	COG3401	FG-GAP repeat protein
DA116_RS27645	COG1846	Transcriptional regulator
DA116_RS27650	COG2814	Major facilitator Superfamily
DA116_RS27670	COG5297	Belongs to the glycosyl hydrolase family 6
DA116_RS27680	COG4106	trans-aconitate 2-methyltransferase activity
DA116_RS27700	COG0656	L-ascorbic acid biosynthetic process
DA116_RS27710	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DA116_RS27735	COG3250	beta-galactosidase activity
DA116_RS27745	COG0477	Major facilitator Superfamily
DA116_RS27785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA116_RS27800	COG3383	formate dehydrogenase (NAD+) activity
DA116_RS27805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA116_RS27815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS27835	COG1129	ABC transporter
DA116_RS27840	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA116_RS27850	COG0673	inositol 2-dehydrogenase activity
DA116_RS27915	COG2223	nitrite transmembrane transporter activity
DA116_RS27925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DA116_RS27935	COG0045	succinate-CoA ligase (ADP-forming) activity
DA116_RS27945	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS27970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA116_RS27985	COG2182	Extracellular solute-binding protein
DA116_RS27990	COG1175	transmembrane transport
DA116_RS27995	COG0395	ABC-type sugar transport system, permease component
DA116_RS28015	COG0714	Associated with various cellular activities
DA116_RS28020	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DA116_RS28075	COG0747	negative chemotaxis
DA116_RS28080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA116_RS28105	COG0438	transferase activity, transferring glycosyl groups
DA116_RS28125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA116_RS28155	COG0477	Major facilitator Superfamily
DA116_RS28165	COG3467	pyridoxamine 5'-phosphate
DA116_RS28170	COG0346	lactoylglutathione lyase activity
DA116_RS28185	COG0438	transferase activity, transferring glycosyl groups
DA116_RS28195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA116_RS28220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA116_RS28240	COG0406	alpha-ribazole phosphatase activity
DA116_RS28245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DA116_RS28250	COG0166	Belongs to the GPI family
DA116_RS28265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA116_RS28295	COG2409	Drug exporters of the RND superfamily
DA116_RS28300	COG2197	response regulator
DA116_RS28305	COG4585	Histidine kinase
DA116_RS28320	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS28340	COG0641	radical SAM
DA116_RS28345	COG2746	aminoglycoside 3-N-acetyltransferase activity
DA116_RS28355	COG3903	Transcriptional regulator
DA116_RS28355	COG3629	intracellular signal transduction
DA116_RS28375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DA116_RS28380	COG3250	beta-galactosidase activity
DA116_RS28385	COG0395	ABC-type sugar transport system, permease component
DA116_RS28390	COG1175	transmembrane transport
DA116_RS28400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS28410	COG1486	melibiose metabolic process
DA116_RS28425	COG3469	chitinase activity
DA116_RS28435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DA116_RS28470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS28485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA116_RS28490	COG3938	Belongs to the proline racemase family
DA116_RS28510	COG1175	transmembrane transport
DA116_RS28515	COG0395	ABC-type sugar transport system, permease component
DA116_RS28520	COG0366	Alpha amylase catalytic
DA116_RS28535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS28540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS28550	COG1414	Transcriptional regulator
DA116_RS28580	COG1011	Hydrolase
DA116_RS28600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA116_RS28605	COG0574	Belongs to the PEP-utilizing enzyme family
DA116_RS28605	COG3848	Pyruvate phosphate dikinase
DA116_RS28610	COG0028	Belongs to the TPP enzyme family
DA116_RS28640	COG0202	RNA polymerase activity
DA116_RS28645	COG3511	phospholipase C
DA116_RS28670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DA116_RS28680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS28680	COG1672	PFAM Archaeal ATPase
DA116_RS28690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA116_RS28695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA116_RS28700	COG3485	protocatechuate 3,4-dioxygenase
DA116_RS28705	COG3485	protocatechuate 3,4-dioxygenase
DA116_RS28740	COG1793	dna ligase
DA116_RS28830	COG1834	amidinotransferase
DA116_RS28835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA116_RS28840	COG0488	(ABC) transporter
DA116_RS28865	COG1515	deoxyribonuclease V activity
DA116_RS28895	COG0183	Belongs to the thiolase family
DA116_RS28900	COG1024	Enoyl-CoA hydratase
DA116_RS28900	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA116_RS28920	COG1129	ABC transporter
DA116_RS28930	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA116_RS28935	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS28945	COG1113	amino acid transport
DA116_RS28955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS28975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA116_RS28985	COG0488	(ABC) transporter
DA116_RS28990	COG2183	response to ionizing radiation
DA116_RS29025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DA116_RS29070	COG1134	teichoic acid transport
DA116_RS29085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DA116_RS29095	COG1657	PFAM Prenyltransferase squalene oxidase
DA116_RS29110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DA116_RS29115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DA116_RS29135	COG2365	Tyrosine phosphatase family
DA116_RS29150	COG2755	lipolytic protein G-D-S-L family
DA116_RS29205	COG0477	Major facilitator Superfamily
DA116_RS29215	COG0583	DNA-binding transcription factor activity
DA116_RS29220	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS29230	COG1063	alcohol dehydrogenase
DA116_RS29235	COG0156	8-amino-7-oxononanoate synthase activity
DA116_RS29240	COG0583	DNA-binding transcription factor activity
DA116_RS29275	COG1454	alcohol dehydrogenase
DA116_RS29295	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
DA116_RS29310	COG0477	Major facilitator Superfamily
DA116_RS29330	COG3469	chitinase activity
DA116_RS29335	COG3548	integral membrane protein
DA116_RS29340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS29355	COG0174	glutamine synthetase
DA116_RS29375	COG0006	proline dipeptidase activity
DA116_RS29380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA116_RS29385	COG0022	dehydrogenase e1 component
DA116_RS29390	COG0402	S-adenosylhomocysteine deaminase activity
DA116_RS29415	COG2267	carboxylic ester hydrolase activity
DA116_RS29465	COG0537	adenosine 5'-monophosphoramidase activity
DA116_RS29470	COG0494	nUDIX hydrolase
DA116_RS29485	COG2188	Transcriptional regulator
DA116_RS29495	COG3962	Belongs to the TPP enzyme family
DA116_RS29500	COG3718	enzyme involved in inositol metabolism
DA116_RS29565	COG3321	synthase
DA116_RS29565	COG0604	alcohol dehydrogenase
DA116_RS29585	COG0604	alcohol dehydrogenase
DA116_RS29585	COG3321	synthase
DA116_RS29610	COG2197	response regulator
DA116_RS29620	COG2197	response regulator
DA116_RS29675	COG1252	NADH dehydrogenase
DA116_RS29690	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS29735	COG2610	gluconate transmembrane transporter activity
DA116_RS29740	COG4948	Mandelate Racemase Muconate Lactonizing
DA116_RS29750	COG1846	Transcriptional regulator
DA116_RS29760	COG2326	polyphosphate kinase activity
DA116_RS29770	COG2353	YceI-like domain
DA116_RS29780	COG3485	protocatechuate 3,4-dioxygenase
DA116_RS29790	COG3284	Transcriptional regulator
DA116_RS29830	COG4221	oxidoreductase activity
DA116_RS29890	COG0583	DNA-binding transcription factor activity
DA116_RS29905	COG1609	Transcriptional regulator
DA116_RS29920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA116_RS29930	COG0242	peptide deformylase activity
DA116_RS29970	COG3409	Peptidoglycan-binding domain 1 protein
DA116_RS30000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA116_RS30000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA116_RS30010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA116_RS30025	COG0517	IMP dehydrogenase activity
DA116_RS30025	COG0516	GMP reductase activity
DA116_RS30065	COG1063	alcohol dehydrogenase
DA116_RS30085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA116_RS30090	COG0463	Glycosyl transferase, family 2
DA116_RS30095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DA116_RS30135	COG1053	succinate dehydrogenase
DA116_RS30145	COG0583	DNA-binding transcription factor activity
DA116_RS30150	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS30160	COG0583	DNA-binding transcription factor activity
DA116_RS30210	COG0726	polysaccharide deacetylase
DA116_RS30215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DA116_RS30215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DA116_RS30225	COG0596	Alpha beta hydrolase
DA116_RS30255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA116_RS30295	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS30300	COG4948	Mandelate Racemase Muconate Lactonizing
DA116_RS30310	COG1129	ABC transporter
DA116_RS30315	COG1879	ABC-type sugar transport system periplasmic component
DA116_RS30320	COG2186	Transcriptional regulator
DA116_RS30345	COG0395	ABC-type sugar transport system, permease component
DA116_RS30350	COG1175	transmembrane transport
DA116_RS30360	COG1609	Transcriptional regulator
DA116_RS30365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS30410	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS30430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DA116_RS30435	COG0297	glycogen (starch) synthase activity
DA116_RS30455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DA116_RS30460	COG2267	carboxylic ester hydrolase activity
DA116_RS30475	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DA116_RS30490	COG1132	(ABC) transporter
DA116_RS30505	COG0668	transmembrane transport
DA116_RS30515	COG2838	Isocitrate dehydrogenase
DA116_RS30565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS30570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS30580	COG1126	abc transporter atp-binding protein
DA116_RS30585	COG0765	amino acid transport
DA116_RS30595	COG1846	Transcriptional regulator
DA116_RS30600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA116_RS30605	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS30630	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS30635	COG4689	acetoacetate decarboxylase
DA116_RS30650	COG0174	glutamine synthetase
DA116_RS30675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS30680	COG0431	NADPH-dependent FMN reductase
DA116_RS30695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA116_RS30705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS30710	COG0765	amino acid transport
DA116_RS30730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS30735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA116_RS30740	COG1414	Transcriptional regulator
DA116_RS30765	COG2814	Major facilitator Superfamily
DA116_RS30785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA116_RS30790	COG2186	Transcriptional regulator
DA116_RS30800	COG1609	Transcriptional regulator
DA116_RS30805	COG0673	inositol 2-dehydrogenase activity
DA116_RS30810	COG0673	inositol 2-dehydrogenase activity
DA116_RS30815	COG1609	Transcriptional regulator
DA116_RS30825	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS30830	COG0673	inositol 2-dehydrogenase activity
DA116_RS30840	COG0673	inositol 2-dehydrogenase activity
DA116_RS30865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA116_RS30880	COG3321	synthase
DA116_RS30880	COG0604	alcohol dehydrogenase
DA116_RS30915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DA116_RS30940	COG1819	glycosyl
DA116_RS30950	COG1131	(ABC) transporter
DA116_RS30960	COG3321	synthase
DA116_RS30960	COG0604	alcohol dehydrogenase
DA116_RS30985	COG3321	synthase
DA116_RS30985	COG0604	alcohol dehydrogenase
DA116_RS31030	COG3321	synthase
DA116_RS31030	COG0604	alcohol dehydrogenase
DA116_RS31045	COG0604	alcohol dehydrogenase
DA116_RS31045	COG3321	synthase
DA116_RS31050	COG0604	alcohol dehydrogenase
DA116_RS31050	COG3321	synthase
DA116_RS31070	COG1819	glycosyl
DA116_RS31085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA116_RS31095	COG1595	DNA-templated transcription, initiation
DA116_RS31100	COG1764	response to oxidative stress
DA116_RS31110	COG1053	succinate dehydrogenase
DA116_RS31120	COG1595	DNA-templated transcription, initiation
DA116_RS31135	COG0438	transferase activity, transferring glycosyl groups
DA116_RS31140	COG0438	transferase activity, transferring glycosyl groups
DA116_RS31145	COG0300	oxidoreductase activity
DA116_RS31170	COG2268	Band 7 protein
DA116_RS31190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DA116_RS31195	COG0121	glutamine amidotransferase
DA116_RS31200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DA116_RS31205	COG3360	Dodecin
DA116_RS31230	COG2226	methyltransferase
DA116_RS31245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA116_RS31255	COG2197	response regulator
DA116_RS31260	COG0277	FAD linked oxidase domain protein
DA116_RS31265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS31320	COG1192	Involved in chromosome partitioning
DA116_RS31365	COG1475	DNA binding
DA116_RS31500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DA116_RS31510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA116_RS31515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS31520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS31535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DA116_RS31555	COG1309	transcriptional regulator
DA116_RS31570	COG1960	acyl-CoA dehydrogenase activity
DA116_RS31575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS31575	COG1042	CoA-binding domain protein
DA116_RS31575	COG0045	succinate-CoA ligase (ADP-forming) activity
DA116_RS31605	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA116_RS31615	COG3842	ATPase activity
DA116_RS31800	COG0488	(ABC) transporter
DA116_RS31805	COG0583	DNA-binding transcription factor activity
DA116_RS31820	COG3655	Transcriptional regulator
DA116_RS31860	COG1864	DNA RNA non-specific endonuclease
DA116_RS31860	COG3591	Belongs to the peptidase S1B family
DA116_RS31870	COG1196	nuclear chromosome segregation
DA116_RS31870	COG0741	lytic transglycosylase activity
DA116_RS31870	COG0739	heme binding
DA116_RS31900	COG1725	Transcriptional regulator
DA116_RS31925	COG0463	Glycosyl transferase, family 2
DA116_RS32010	COG0640	Transcriptional regulator
DA116_RS32245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA116_RS32285	COG1063	alcohol dehydrogenase
DA116_RS32425	COG4977	sequence-specific DNA binding
DA116_RS32435	COG2050	protein possibly involved in aromatic compounds catabolism
DA116_RS32465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA116_RS32490	COG3547	Transposase (IS116 IS110 IS902 family)
DA116_RS32495	COG1846	Transcriptional regulator
DA116_RS32515	COG0477	Major facilitator Superfamily
DA116_RS32565	COG2124	cytochrome p450
DA116_RS32575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS32575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS32630	COG2815	serine threonine protein kinase
DA116_RS32630	COG0515	serine threonine protein kinase
DA116_RS32640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA116_RS32645	COG1672	PFAM Archaeal ATPase
DA116_RS32645	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS32805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA116_RS32835	COG2897	thiosulfate sulfurtransferase activity
DA116_RS32970	COG1278	Cold shock
DA116_RS33085	COG1278	Cold shock
DA116_RS33230	COG0647	UMP catabolic process
DA116_RS33235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS33240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS33245	COG1120	ATPase activity
DA116_RS33270	COG0497	DNA recombination
DA116_RS33280	COG0438	transferase activity, transferring glycosyl groups
DA116_RS33280	COG0297	glycogen (starch) synthase activity
DA116_RS33295	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS33300	COG0504	CTP synthase activity
DA116_RS33315	COG0686	Belongs to the AlaDH PNT family
DA116_RS33330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DA116_RS33335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DA116_RS33340	COG1187	pseudouridine synthase activity
DA116_RS33355	COG0477	Major facilitator Superfamily
DA116_RS33360	COG0494	nUDIX hydrolase
DA116_RS33370	COG3541	Predicted nucleotidyltransferase
DA116_RS33400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DA116_RS33410	COG1160	GTP binding
DA116_RS33425	COG3583	domain protein
DA116_RS33440	COG0411	ABC transporter
DA116_RS33480	COG0671	phosphoesterase, PA-phosphatase related
DA116_RS33490	COG1960	acyl-CoA dehydrogenase activity
DA116_RS33495	COG1799	cell septum assembly
DA116_RS33510	COG0330	HflC and HflK could
DA116_RS33530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DA116_RS33585	COG1725	Transcriptional regulator
DA116_RS33610	COG0726	polysaccharide deacetylase
DA116_RS33610	COG1649	PFAM Uncharacterised BCR, COG1649
DA116_RS33645	COG0515	serine threonine protein kinase
DA116_RS33645	COG2815	serine threonine protein kinase
DA116_RS33665	COG1595	DNA-templated transcription, initiation
DA116_RS33700	COG2188	Transcriptional regulator
DA116_RS33705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DA116_RS33715	COG1309	transcriptional regulator
DA116_RS33720	COG0243	molybdopterin cofactor binding
DA116_RS33725	COG2851	Citrate transporter
DA116_RS33765	COG0477	Major facilitator Superfamily
DA116_RS33855	COG1960	acyl-CoA dehydrogenase activity
DA116_RS33880	COG2149	membrane
DA116_RS33885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DA116_RS33920	COG1063	alcohol dehydrogenase
DA116_RS33925	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS33935	COG3265	gluconokinase activity
DA116_RS33940	COG2186	Transcriptional regulator
DA116_RS33950	COG3012	SEC-C Motif Domain Protein
DA116_RS33975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS34010	COG0667	Aldo Keto reductase
DA116_RS34015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS34025	COG0598	Magnesium transport protein CorA
DA116_RS34030	COG0588	phosphoglycerate mutase activity
DA116_RS34045	COG0215	cysteine-tRNA ligase activity
DA116_RS34075	COG2186	Transcriptional regulator
DA116_RS34085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA116_RS34090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA116_RS34095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA116_RS34100	COG1414	Transcriptional regulator
DA116_RS34105	COG1410	methionine synthase
DA116_RS34105	COG0646	methionine synthase
DA116_RS34110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA116_RS34115	COG0747	negative chemotaxis
DA116_RS34120	COG0747	negative chemotaxis
DA116_RS34125	COG2197	response regulator
DA116_RS34160	COG1222	aaa ATPase
DA116_RS34165	COG4122	O-methyltransferase activity
DA116_RS34180	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DA116_RS34185	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DA116_RS34190	COG1609	Transcriptional regulator
DA116_RS34200	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DA116_RS34285	COG0564	pseudouridine synthase activity
DA116_RS34290	COG2124	cytochrome p450
DA116_RS34320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA116_RS34325	COG4175	Glycine betaine
DA116_RS34325	COG0517	IMP dehydrogenase activity
DA116_RS34330	COG4176	ABC-type proline glycine betaine transport system permease component
DA116_RS34340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA116_RS34355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA116_RS34360	COG0531	amino acid
DA116_RS34370	COG0174	glutamine synthetase
DA116_RS34375	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS34380	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS34430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DA116_RS34435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DA116_RS34440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DA116_RS34445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA116_RS34455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DA116_RS34490	COG1649	PFAM Uncharacterised BCR, COG1649
DA116_RS34500	COG0697	spore germination
DA116_RS34535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DA116_RS34540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DA116_RS34545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DA116_RS34550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA116_RS34590	COG0165	Argininosuccinate lyase
DA116_RS34605	COG0477	Major facilitator Superfamily
DA116_RS34610	COG0204	Acyl-transferase
DA116_RS34610	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS34640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA116_RS34645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA116_RS34650	COG2011	ABC-type metal ion transport system permease component
DA116_RS34655	COG1464	Belongs to the NlpA lipoprotein family
DA116_RS34675	COG1648	precorrin-2 dehydrogenase activity
DA116_RS34675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA116_RS34685	COG0494	nUDIX hydrolase
DA116_RS34740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA116_RS34750	COG0456	acetyltransferase
DA116_RS34750	COG0454	-acetyltransferase
DA116_RS34790	COG1175	transmembrane transport
DA116_RS34795	COG0395	ABC-type sugar transport system, permease component
DA116_RS34825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA116_RS34840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DA116_RS34845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA116_RS34865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA116_RS34870	COG1560	Kdo2-lipid A biosynthetic process
DA116_RS34875	COG0438	transferase activity, transferring glycosyl groups
DA116_RS34885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DA116_RS34890	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DA116_RS34895	COG0217	transcriptional regulatory protein
DA116_RS34900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DA116_RS34905	COG0632	four-way junction helicase activity
DA116_RS34910	COG2255	four-way junction helicase activity
DA116_RS34920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA116_RS34925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA116_RS34930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DA116_RS34940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA116_RS34945	COG1196	nuclear chromosome segregation
DA116_RS34950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA116_RS34960	COG0124	histidyl-tRNA synthetase
DA116_RS34975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DA116_RS34995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DA116_RS35000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DA116_RS35010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA116_RS35020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DA116_RS35025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA116_RS35030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DA116_RS35040	COG0006	proline dipeptidase activity
DA116_RS35045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DA116_RS35050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA116_RS35060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DA116_RS35065	COG0540	Belongs to the ATCase OTCase family
DA116_RS35070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA116_RS35080	COG0505	Belongs to the CarA family
DA116_RS35085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA116_RS35090	COG0167	dihydroorotate dehydrogenase activity
DA116_RS35095	COG0284	orotidine-5'-phosphate decarboxylase activity
DA116_RS35105	COG0194	GDP metabolic process
DA116_RS35110	COG1758	RNA polymerase activity
DA116_RS35120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA116_RS35135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DA116_RS35145	COG2409	Drug exporters of the RND superfamily
DA116_RS35150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA116_RS35155	COG2390	Transcriptional regulator
DA116_RS35170	COG0531	amino acid
DA116_RS35185	COG2188	Transcriptional regulator
DA116_RS35195	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA116_RS35205	COG3842	ATPase activity
DA116_RS35210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA116_RS35225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA116_RS35250	COG2233	PERMEase
DA116_RS35260	COG0738	Major facilitator superfamily
DA116_RS35270	COG1090	epimerase
DA116_RS35285	COG3201	nicotinamide mononucleotide transporter
DA116_RS35290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA116_RS35290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA116_RS35295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DA116_RS35300	COG0140	phosphoribosyl-ATP diphosphatase activity
DA116_RS35305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DA116_RS35400	COG1216	Glycosyl transferase, family 2
DA116_RS35415	COG2270	Major facilitator Superfamily
DA116_RS35425	COG2364	Membrane
DA116_RS35430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA116_RS35460	COG0438	transferase activity, transferring glycosyl groups
DA116_RS35470	COG1984	allophanate hydrolase subunit 2
DA116_RS35475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DA116_RS35480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DA116_RS35485	COG4336	lyase activity
DA116_RS35490	COG2814	Major facilitator Superfamily
DA116_RS35515	COG0531	amino acid
DA116_RS35535	COG2018	Roadblock/LC7 domain
DA116_RS35555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA116_RS35560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA116_RS35570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS35580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DA116_RS35595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA116_RS35655	COG1252	NADH dehydrogenase
DA116_RS35685	COG0579	oxidoreductase
DA116_RS35690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DA116_RS35725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA116_RS35730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DA116_RS35790	COG1643	Atp-dependent helicase
DA116_RS35825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DA116_RS35855	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA116_RS35860	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA116_RS35865	COG1129	ABC transporter
DA116_RS35870	COG1879	ABC-type sugar transport system periplasmic component
DA116_RS35875	COG1609	Transcriptional regulator
DA116_RS35915	COG0542	response to heat
DA116_RS35920	COG2837	iron assimilation
DA116_RS35925	COG2197	response regulator
DA116_RS35940	COG2409	Drug exporters of the RND superfamily
DA116_RS35945	COG2409	Drug exporters of the RND superfamily
DA116_RS35960	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS35975	COG1295	ribonuclease BN
DA116_RS35980	COG2186	Transcriptional regulator
DA116_RS35995	COG1175	transmembrane transport
DA116_RS36000	COG0395	ABC-type sugar transport system, permease component
DA116_RS36030	COG0783	Belongs to the Dps family
DA116_RS36060	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS36075	COG0745	RESPONSE REGULATOR receiver
DA116_RS36080	COG2205	protein histidine kinase activity
DA116_RS36110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA116_RS36120	COG1024	Enoyl-CoA hydratase
DA116_RS36130	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS36135	COG1960	acyl-CoA dehydrogenase activity
DA116_RS36185	COG3290	protein histidine kinase activity
DA116_RS36200	COG0395	ABC-type sugar transport system, permease component
DA116_RS36205	COG1175	transmembrane transport
DA116_RS36310	COG0395	ABC-type sugar transport system, permease component
DA116_RS36315	COG1063	alcohol dehydrogenase
DA116_RS36320	COG0673	inositol 2-dehydrogenase activity
DA116_RS36360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA116_RS36365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA116_RS36375	COG0438	transferase activity, transferring glycosyl groups
DA116_RS36385	COG0789	Transcriptional regulator
DA116_RS36460	COG1674	ftsk spoiiie
DA116_RS36465	COG1404	Belongs to the peptidase S8 family
DA116_RS36470	COG0464	growth
DA116_RS36530	COG0477	Major facilitator Superfamily
DA116_RS36540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA116_RS36545	COG0277	FAD linked oxidase domain protein
DA116_RS36550	COG1309	transcriptional regulator
DA116_RS36575	COG0411	ABC transporter
DA116_RS36620	COG3321	synthase
DA116_RS36620	COG0604	alcohol dehydrogenase
DA116_RS36620	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS36640	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DA116_RS36650	COG0488	(ABC) transporter
DA116_RS36655	COG0477	Major facilitator Superfamily
DA116_RS36660	COG0745	RESPONSE REGULATOR receiver
DA116_RS36665	COG2205	protein histidine kinase activity
DA116_RS36690	COG3835	regulator
DA116_RS36715	COG0725	ABC transporter, periplasmic molybdate-binding protein
DA116_RS36755	COG0235	Class ii aldolase
DA116_RS36770	COG0300	oxidoreductase activity
DA116_RS36805	COG0277	FAD linked oxidase domain protein
DA116_RS36825	COG2382	esterase
DA116_RS36830	COG1132	(ABC) transporter
DA116_RS36850	COG1120	ATPase activity
DA116_RS36855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS36860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS36875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA116_RS36905	COG0640	Transcriptional regulator
DA116_RS36920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS36920	COG3320	Male sterility
DA116_RS36950	COG3845	ABC transporter
DA116_RS36970	COG0009	L-threonylcarbamoyladenylate synthase
DA116_RS36980	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS36985	COG0583	DNA-binding transcription factor activity
DA116_RS36995	COG0596	Alpha beta hydrolase
DA116_RS37030	COG3903	Transcriptional regulator
DA116_RS37030	COG3629	intracellular signal transduction
DA116_RS37040	COG0596	Alpha beta hydrolase
DA116_RS37050	COG1621	beta-fructofuranosidase activity
DA116_RS37060	COG1175	transmembrane transport
DA116_RS37065	COG0395	ABC-type sugar transport system, permease component
DA116_RS37070	COG1621	beta-fructofuranosidase activity
DA116_RS37075	COG1609	Transcriptional regulator
DA116_RS37100	COG2207	Transcriptional regulator
DA116_RS37105	COG2223	nitrite transmembrane transporter activity
DA116_RS37130	COG0745	RESPONSE REGULATOR receiver
DA116_RS37145	COG2197	response regulator
DA116_RS37170	COG0181	hydroxymethylbilane synthase activity
DA116_RS37225	COG0366	Alpha amylase catalytic
DA116_RS37235	COG3281	Trehalose synthase
DA116_RS37240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DA116_RS37310	COG5002	protein histidine kinase activity
DA116_RS37350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA116_RS37380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS37380	COG1672	PFAM Archaeal ATPase
DA116_RS37410	COG2340	Cysteine-rich secretory protein family
DA116_RS37435	COG0515	serine threonine protein kinase
DA116_RS37435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA116_RS37445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA116_RS37460	COG0667	Aldo Keto reductase
DA116_RS37475	COG2304	oxidoreductase activity
DA116_RS37480	COG0328	RNA-DNA hybrid ribonuclease activity
DA116_RS37495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA116_RS37505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA116_RS37520	COG0596	Alpha beta hydrolase
DA116_RS37525	COG0740	serine-type endopeptidase activity
DA116_RS37535	COG1396	sequence-specific DNA binding
DA116_RS37540	COG2318	DinB family
DA116_RS37570	COG0842	Transport permease protein
DA116_RS37570	COG1131	(ABC) transporter
DA116_RS37570	COG1716	ATPase activity
DA116_RS37590	COG0667	Aldo Keto reductase
DA116_RS37595	COG0583	DNA-binding transcription factor activity
DA116_RS37605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA116_RS37610	COG0346	lactoylglutathione lyase activity
DA116_RS37625	COG0667	Aldo Keto reductase
DA116_RS37635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA116_RS37660	COG2188	Transcriptional regulator
DA116_RS37665	COG4941	Belongs to the sigma-70 factor family
DA116_RS37685	COG2409	Drug exporters of the RND superfamily
DA116_RS37690	COG1846	Transcriptional regulator
DA116_RS37695	COG0702	epimerase
DA116_RS37755	COG0640	Transcriptional regulator
DA116_RS37875	COG1024	Enoyl-CoA hydratase
DA116_RS37925	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS37950	COG2070	2-Nitropropane dioxygenase
DA116_RS37955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS37975	COG0515	serine threonine protein kinase
DA116_RS37985	COG1960	acyl-CoA dehydrogenase activity
DA116_RS38030	COG2376	Dihydroxyacetone kinase
DA116_RS38035	COG1461	Dihydroxyacetone kinase
DA116_RS38050	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS38075	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA116_RS38075	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS38080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA116_RS38100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA116_RS38105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA116_RS38115	COG2890	protein-(glutamine-N5) methyltransferase activity
DA116_RS38120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DA116_RS38140	COG3458	cephalosporin-C deacetylase activity
DA116_RS38160	COG2226	methyltransferase
DA116_RS38165	COG1695	Transcriptional regulator
DA116_RS38180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA116_RS38185	COG1686	Belongs to the peptidase S11 family
DA116_RS38200	COG2066	Belongs to the glutaminase family
DA116_RS38215	COG1113	amino acid transport
DA116_RS38220	COG2186	Transcriptional regulator
DA116_RS38225	COG1968	undecaprenyl-diphosphatase activity
DA116_RS38230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA116_RS38235	COG1993	acr, cog1993
DA116_RS38240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA116_RS38270	COG1175	transmembrane transport
DA116_RS38275	COG0395	ABC-type sugar transport system, permease component
DA116_RS38295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DA116_RS38365	COG3291	Pkd domain containing protein
DA116_RS38450	COG3832	glyoxalase III activity
DA116_RS38455	COG2274	protein secretion by the type I secretion system
DA116_RS38490	COG2197	response regulator
DA116_RS38500	COG1132	(ABC) transporter
DA116_RS38510	COG0515	serine threonine protein kinase
DA116_RS38555	COG3608	succinylglutamate desuccinylase aspartoacylase
DA116_RS38555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DA116_RS38590	COG0789	Transcriptional regulator
DA116_RS38615	COG3345	alpha-galactosidase
DA116_RS38650	COG0019	diaminopimelate decarboxylase activity
DA116_RS38660	COG4264	IucA IucC family
DA116_RS38675	COG1132	(ABC) transporter
DA116_RS38685	COG1937	Protein conserved in bacteria
DA116_RS38710	COG4221	oxidoreductase activity
DA116_RS38720	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS38740	COG0395	ABC-type sugar transport system, permease component
DA116_RS38750	COG1940	carbohydrate kinase activity
DA116_RS38750	COG1846	Transcriptional regulator
DA116_RS38780	COG0673	inositol 2-dehydrogenase activity
DA116_RS38830	COG1940	carbohydrate kinase activity
DA116_RS38840	COG1175	transmembrane transport
DA116_RS38845	COG0395	ABC-type sugar transport system, permease component
DA116_RS38860	COG1072	(Pantothenic acid kinase))
DA116_RS38925	COG0673	inositol 2-dehydrogenase activity
DA116_RS38930	COG0667	Aldo Keto reductase
DA116_RS38940	COG3250	beta-galactosidase activity
DA116_RS38945	COG1609	Transcriptional regulator
DA116_RS38965	COG0702	epimerase
DA116_RS38990	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS39065	COG1595	DNA-templated transcription, initiation
DA116_RS39080	COG3290	protein histidine kinase activity
DA116_RS39095	COG2208	phosphoserine phosphatase activity
DA116_RS39095	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS39095	COG2172	sigma factor antagonist activity
DA116_RS39105	COG0477	Major facilitator Superfamily
DA116_RS39185	COG1228	amidohydrolase
DA116_RS39190	COG1132	(ABC) transporter
DA116_RS39220	COG3739	integral membrane protein
DA116_RS39235	COG0667	Aldo Keto reductase
DA116_RS39245	COG1175	transmembrane transport
DA116_RS39250	COG0395	ABC-type sugar transport system, permease component
DA116_RS39265	COG2186	Transcriptional regulator
DA116_RS39270	COG4948	Mandelate Racemase Muconate Lactonizing
DA116_RS39280	COG0800	Aldolase
DA116_RS39325	COG2124	cytochrome p450
DA116_RS39360	COG2197	response regulator
DA116_RS39380	COG1120	ATPase activity
DA116_RS39420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA116_RS39450	COG1191	sigma factor activity
DA116_RS39475	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS39480	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS39485	COG2172	sigma factor antagonist activity
DA116_RS39505	COG1063	alcohol dehydrogenase
DA116_RS39515	COG0129	dihydroxy-acid dehydratase activity
DA116_RS39610	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS39625	COG1309	transcriptional regulator
DA116_RS39630	COG0590	tRNA wobble adenosine to inosine editing
DA116_RS39745	COG3265	gluconokinase activity
DA116_RS39750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DA116_RS39755	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS39795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA116_RS39800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS39825	COG0326	Molecular chaperone. Has ATPase activity
DA116_RS39840	COG0596	Alpha beta hydrolase
DA116_RS39850	COG1136	(ABC) transporter
DA116_RS39850	COG0577	efflux transmembrane transporter activity
DA116_RS39865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DA116_RS39915	COG2223	nitrite transmembrane transporter activity
DA116_RS39920	COG1349	DNA-binding transcription factor activity
DA116_RS39935	COG1132	(ABC) transporter
DA116_RS39940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA116_RS39970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DA116_RS39980	COG0475	glutathione-regulated potassium exporter activity
DA116_RS39990	COG2124	cytochrome p450
DA116_RS39995	COG2124	cytochrome p450
DA116_RS40020	COG0287	Prephenate dehydrogenase
DA116_RS40025	COG0577	efflux transmembrane transporter activity
DA116_RS40025	COG1136	(ABC) transporter
DA116_RS40030	COG1136	(ABC) transporter
DA116_RS40030	COG0577	efflux transmembrane transporter activity
DA116_RS40045	COG0745	RESPONSE REGULATOR receiver
DA116_RS40050	COG2205	protein histidine kinase activity
DA116_RS40065	COG0475	glutathione-regulated potassium exporter activity
DA116_RS40110	COG1140	nitrate reductase beta subunit
DA116_RS40165	COG0589	response to stress
DA116_RS40190	COG2824	Alkylphosphonate utilization operon protein PhnA
DA116_RS40210	COG0659	secondary active sulfate transmembrane transporter activity
DA116_RS40235	COG1733	regulation of RNA biosynthetic process
DA116_RS40245	COG2080	2 iron, 2 sulfur cluster binding
DA116_RS40245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DA116_RS40280	COG1063	alcohol dehydrogenase
DA116_RS40285	COG2130	NADP-dependent
DA116_RS40305	COG0667	Aldo Keto reductase
DA116_RS40325	COG0028	Belongs to the TPP enzyme family
DA116_RS40330	COG2175	clavaminate synthase activity
DA116_RS40340	COG4521	taurine ABC transporter
DA116_RS40345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS40365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DA116_RS40375	COG0596	Alpha beta hydrolase
DA116_RS40415	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS40425	COG1063	alcohol dehydrogenase
DA116_RS40470	COG0395	ABC-type sugar transport system, permease component
DA116_RS40485	COG1609	Transcriptional regulator
DA116_RS40495	COG4221	oxidoreductase activity
DA116_RS40505	COG4977	sequence-specific DNA binding
DA116_RS40520	COG4552	Acetyltransferase involved in intracellular survival and related
DA116_RS40540	COG3835	regulator
DA116_RS40545	COG0187	DNA topoisomerase II activity
DA116_RS40580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DA116_RS40585	COG4191	Histidine kinase
DA116_RS40585	COG2205	protein histidine kinase activity
DA116_RS40585	COG0745	RESPONSE REGULATOR receiver
DA116_RS40600	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS40650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA116_RS40665	COG4191	Histidine kinase
DA116_RS40680	COG3250	beta-galactosidase activity
DA116_RS40735	COG2197	response regulator
DA116_RS40735	COG3903	Transcriptional regulator
DA116_RS40785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DA116_RS40790	COG1295	ribonuclease BN
DA116_RS40800	COG0702	epimerase
DA116_RS40860	COG5002	protein histidine kinase activity
DA116_RS40865	COG0745	RESPONSE REGULATOR receiver
DA116_RS40875	COG2409	Drug exporters of the RND superfamily
DA116_RS40910	COG4221	oxidoreductase activity
DA116_RS40915	COG0583	DNA-binding transcription factor activity
DA116_RS40920	COG0483	inositol monophosphate 1-phosphatase activity
DA116_RS40930	COG0477	Major facilitator Superfamily
DA116_RS40965	COG2188	Transcriptional regulator
DA116_RS40980	COG0019	diaminopimelate decarboxylase activity
DA116_RS41055	COG0789	Transcriptional regulator
DA116_RS41065	COG1960	acyl-CoA dehydrogenase activity
DA116_RS41070	COG0604	alcohol dehydrogenase
DA116_RS41105	COG0583	DNA-binding transcription factor activity
DA116_RS41110	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS41140	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS41145	COG2197	response regulator
DA116_RS41305	COG2860	membrane
DA116_RS41315	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS41335	COG1309	transcriptional regulator
DA116_RS41340	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS41350	COG0778	Nitroreductase
DA116_RS41365	COG3842	ATPase activity
DA116_RS41370	COG3842	ATPase activity
DA116_RS41380	COG0395	ABC-type sugar transport system, permease component
DA116_RS41400	COG3284	Transcriptional regulator
DA116_RS41405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DA116_RS41475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DA116_RS41495	COG2340	Cysteine-rich secretory protein family
DA116_RS41560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA116_RS41575	COG1175	transmembrane transport
DA116_RS41580	COG0395	ABC-type sugar transport system, permease component
DA116_RS41590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DA116_RS41605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA116_RS41615	COG2197	response regulator
DA116_RS41620	COG4585	Histidine kinase
DA116_RS41630	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS41645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DA116_RS41660	COG0438	transferase activity, transferring glycosyl groups
DA116_RS41665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA116_RS41670	COG1760	l-serine dehydratase
DA116_RS41675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA116_RS41690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA116_RS41720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DA116_RS41735	COG4176	ABC-type proline glycine betaine transport system permease component
DA116_RS41740	COG4175	Glycine betaine
DA116_RS41740	COG0517	IMP dehydrogenase activity
DA116_RS41745	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS41765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DA116_RS41775	COG4638	Rieske (2fe-2S)
DA116_RS41780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA116_RS41810	COG0640	Transcriptional regulator
DA116_RS41815	COG0346	lactoylglutathione lyase activity
DA116_RS41845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA116_RS41855	COG2197	response regulator
DA116_RS41860	COG3851	Histidine kinase
DA116_RS41870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA116_RS41910	COG1233	COG1233 Phytoene dehydrogenase and related
DA116_RS41935	COG1595	DNA-templated transcription, initiation
DA116_RS41960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA116_RS41970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA116_RS41995	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS42050	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS42070	COG0402	S-adenosylhomocysteine deaminase activity
DA116_RS42115	COG1733	regulation of RNA biosynthetic process
DA116_RS42170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA116_RS42205	COG0667	Aldo Keto reductase
DA116_RS42210	COG1366	Belongs to the anti-sigma-factor antagonist family
DA116_RS42240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA116_RS42245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA116_RS42250	COG1309	transcriptional regulator
DA116_RS42260	COG0183	Belongs to the thiolase family
DA116_RS42265	COG0596	Alpha beta hydrolase
DA116_RS42305	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS42335	COG1215	transferase activity, transferring glycosyl groups
DA116_RS42370	COG1349	DNA-binding transcription factor activity
DA116_RS42395	COG0577	efflux transmembrane transporter activity
DA116_RS42400	COG1136	(ABC) transporter
DA116_RS42440	COG0698	ribose 5-phosphate isomerase
DA116_RS42460	COG2813	Specifically methylates the guanine in position
DA116_RS42470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA116_RS42475	COG1349	DNA-binding transcription factor activity
DA116_RS42480	COG3387	PFAM Glycoside hydrolase 15-related
DA116_RS42495	COG2608	mercury ion transmembrane transporter activity
DA116_RS42515	COG0395	ABC-type sugar transport system, permease component
DA116_RS42520	COG1175	transmembrane transport
DA116_RS42525	COG1653	transport
DA116_RS42540	COG0673	inositol 2-dehydrogenase activity
DA116_RS42550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA116_RS42550	COG1796	DNA polymerase
DA116_RS42575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA116_RS42595	COG0326	Molecular chaperone. Has ATPase activity
DA116_RS42620	COG3594	Acyltransferase
DA116_RS42660	COG1228	amidohydrolase
DA116_RS42695	COG0318	PFAM AMP-dependent synthetase and ligase
DA116_RS42730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA116_RS42735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS42745	COG2030	dehydratase
DA116_RS42760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA116_RS42815	COG2197	response regulator
DA116_RS42820	COG4585	Histidine kinase
DA116_RS42850	COG1660	Displays ATPase and GTPase activities
DA116_RS42865	COG3345	alpha-galactosidase
DA116_RS42900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DA116_RS42925	COG0204	Acyl-transferase
DA116_RS42960	COG0584	glycerophosphoryl diester phosphodiesterase
DA116_RS43000	COG0671	phosphoesterase, PA-phosphatase related
DA116_RS43030	COG0493	'glutamate synthase
DA116_RS43040	COG0640	Transcriptional regulator
DA116_RS43045	COG1902	pentaerythritol trinitrate reductase activity
DA116_RS43050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DA116_RS43075	COG1960	acyl-CoA dehydrogenase activity
DA116_RS43105	COG2706	6-phosphogluconolactonase activity
DA116_RS43120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA116_RS43125	COG1404	Belongs to the peptidase S8 family
DA116_RS43160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA116_RS43165	COG2151	metal-sulfur cluster biosynthetic enzyme
DA116_RS43170	COG3396	Phenylacetate-CoA oxygenase
DA116_RS43175	COG3460	Phenylacetate-CoA oxygenase
DA116_RS43180	COG3396	Phenylacetate-CoA oxygenase
DA116_RS43255	COG1222	aaa ATPase
DA116_RS43285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA116_RS43300	COG1609	Transcriptional regulator
DA116_RS43310	COG2814	Major facilitator Superfamily
DA116_RS43315	COG0673	inositol 2-dehydrogenase activity
DA116_RS43320	COG1082	Xylose isomerase domain protein TIM barrel
DA116_RS43365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS43370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DA116_RS43390	COG0367	asparagine synthase
DA116_RS43395	COG2814	Major facilitator Superfamily
DA116_RS43400	COG1120	ATPase activity
DA116_RS43405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA116_RS43460	COG1653	transport
DA116_RS43470	COG1136	(ABC) transporter
DA116_RS43470	COG0577	efflux transmembrane transporter activity
DA116_RS43480	COG2197	response regulator
DA116_RS43490	COG1653	transport
DA116_RS43495	COG0432	Pfam Uncharacterised protein family UPF0047
DA116_RS43505	COG1116	anion transmembrane transporter activity
DA116_RS43515	COG2072	flavoprotein involved in K transport
DA116_RS43535	COG1301	dicarboxylic acid transport
DA116_RS43550	COG1132	(ABC) transporter
DA116_RS43555	COG1132	(ABC) transporter
DA116_RS43565	COG0254	rRNA binding
DA116_RS43580	COG1946	Acyl-CoA thioesterase
DA116_RS43590	COG2018	Roadblock/LC7 domain
DA116_RS43660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA116_RS43695	COG1940	carbohydrate kinase activity
DA116_RS43720	COG1012	belongs to the aldehyde dehydrogenase family
DA116_RS43730	COG0488	(ABC) transporter
DA116_RS43735	COG0488	(ABC) transporter
DA116_RS43740	COG0702	epimerase
DA116_RS43745	COG3631	Ketosteroid isomerase-related protein
DA116_RS43765	COG2815	serine threonine protein kinase
DA116_RS43765	COG0515	serine threonine protein kinase
DA116_RS43795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA116_RS43815	COG1082	Xylose isomerase domain protein TIM barrel
DA116_RS43835	COG4213	ABC transporter substrate-binding protein
DA116_RS43845	COG4213	ABC transporter substrate-binding protein
DA116_RS43855	COG4214	carbohydrate transport
DA116_RS43860	COG0586	Pfam SNARE associated Golgi protein
DA116_RS43870	COG2124	cytochrome p450
DA116_RS43885	COG4632	Exopolysaccharide biosynthesis protein
DA116_RS43885	COG5434	Belongs to the glycosyl hydrolase 28 family
DA116_RS43910	COG1960	acyl-CoA dehydrogenase activity
DA116_RS43925	COG0492	ferredoxin-NADP+ reductase activity
DA116_RS43925	COG3118	belongs to the thioredoxin family
DA116_RS43955	COG1960	acyl-CoA dehydrogenase activity
DA116_RS43975	COG3442	glutamine amidotransferase
DA116_RS44005	COG3275	phosphorelay sensor kinase activity
DA116_RS44025	COG1522	sequence-specific DNA binding
DA116_RS44030	COG1834	amidinotransferase
DA116_RS44035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA116_RS44055	COG0829	nickel cation binding
DA116_RS44060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DA116_RS44075	COG0832	Belongs to the urease beta subunit family
DA116_RS44080	COG0831	urea catabolic process
DA116_RS44085	COG1309	transcriptional regulator
DA116_RS44100	COG0740	serine-type endopeptidase activity
DA116_RS44110	COG0791	NLP P60 protein
DA116_RS44115	COG1280	lysine exporter protein (LysE YggA)
DA116_RS44120	COG0583	DNA-binding transcription factor activity
DA116_RS44140	COG0156	8-amino-7-oxononanoate synthase activity
DA116_RS44145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DA116_RS44150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA116_RS44155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DA116_RS44180	COG2226	methyltransferase
DA116_RS44195	COG1136	(ABC) transporter
DA116_RS44200	COG1136	(ABC) transporter
DA116_RS44200	COG0577	efflux transmembrane transporter activity
DA116_RS44210	COG0456	acetyltransferase
DA116_RS44235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA116_RS44240	COG3663	DNA glycosylase
DA116_RS44260	COG4585	Histidine kinase
DA116_RS44265	COG2197	response regulator
DA116_RS44270	COG1940	carbohydrate kinase activity
DA116_RS44275	COG2188	Transcriptional regulator
DA116_RS44300	COG0475	glutathione-regulated potassium exporter activity
DA116_RS44325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA116_RS44330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DA116_RS44410	COG0626	cystathionine gamma-synthase activity
DA116_RS44425	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS44440	COG1522	sequence-specific DNA binding
DA116_RS44455	COG0419	ATPase involved in DNA repair
DA116_RS44460	COG0420	3'-5' exonuclease activity
DA116_RS44465	COG1739	Uncharacterized protein family UPF0029
DA116_RS44475	COG0215	cysteine-tRNA ligase activity
DA116_RS44480	COG1832	CoA-binding protein
DA116_RS44490	COG0640	Transcriptional regulator
DA116_RS44540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA116_RS44600	COG0183	Belongs to the thiolase family
DA116_RS44620	COG1968	undecaprenyl-diphosphatase activity
DA116_RS44660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DA116_RS44680	COG2318	DinB family
DA116_RS44700	COG0747	negative chemotaxis
DA116_RS44745	COG0697	spore germination
DA116_RS44815	COG0384	phenazine biosynthesis protein PhzF
DA116_RS44860	COG0395	ABC-type sugar transport system, permease component
DA116_RS44900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DA116_RS44905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DA116_RS44910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DA116_RS44920	COG0531	amino acid
DA116_RS44940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA116_RS44940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA116_RS44990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA116_RS45015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DA116_RS45020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DA116_RS45035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DA116_RS45035	COG0674	pyruvate-flavodoxin oxidoreductase activity
DA116_RS45040	COG1013	pyruvate-flavodoxin oxidoreductase activity
DA116_RS45115	COG2124	cytochrome p450
DA116_RS45135	COG0351	phosphomethylpyrimidine kinase
DA116_RS45180	COG0515	serine threonine protein kinase
DA116_RS45195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA116_RS45200	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS45200	COG1672	PFAM Archaeal ATPase
DA116_RS45320	COG4977	sequence-specific DNA binding
DA116_RS45355	COG3547	Transposase (IS116 IS110 IS902 family)
DA116_RS45360	COG3415	Transposase
DA116_RS45360	COG2801	Transposase and inactivated derivatives
DA116_RS45385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS45390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA116_RS45395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA116_RS45400	COG1028	Short-chain dehydrogenase reductase Sdr
DA116_RS45405	COG0784	Response regulator, receiver
DA116_RS45405	COG3437	response regulator, receiver
DA116_RS45410	COG2226	methyltransferase
DA116_RS45415	COG0784	Response regulator, receiver
DA116_RS45415	COG3437	response regulator, receiver
DA116_RS45425	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA116_RS45515	COG1672	PFAM Archaeal ATPase
DA116_RS45515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DA116_RS45525	COG1846	Transcriptional regulator
DA116_RS45570	COG3547	Transposase (IS116 IS110 IS902 family)
DA116_RS45600	COG3547	Transposase (IS116 IS110 IS902 family)
DA116_RS45645	COG2318	DinB family
DA116_RS45670	COG0477	Major facilitator Superfamily
DA116_RS45700	COG1175	transmembrane transport
DA116_RS45705	COG0395	ABC-type sugar transport system, permease component
DA116_RS45715	COG0657	acetylesterase activity
DA116_RS45755	COG0473	3-isopropylmalate dehydrogenase activity
DA116_RS45765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA116_RS45830	COG0583	DNA-binding transcription factor activity
DA116_RS45840	COG2814	Major facilitator Superfamily
DA116_RS45880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA116_RS45880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA116_RS45920	COG2226	methyltransferase
DA116_RS45930	COG0477	Major facilitator Superfamily
DA116_RS45935	COG3250	beta-galactosidase activity
DA116_RS45940	COG1028	Short-chain dehydrogenase reductase Sdr