locus-tag	class	description
IPT68_RS00020	COG4565	transcriptional regulatory protein
IPT68_RS00025	COG3290	protein histidine kinase activity
IPT68_RS00050	COG1295	ribonuclease BN
IPT68_RS00075	COG0784	Response regulator, receiver
IPT68_RS00140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPT68_RS00230	COG2318	DinB family
IPT68_RS00235	COG2850	peptidyl-arginine hydroxylation
IPT68_RS00245	COG1506	peptidase
IPT68_RS00245	COG4946	Tricorn protease homolog
IPT68_RS00245	COG0823	Involved in the tonB-independent uptake of proteins
IPT68_RS00255	COG2801	Transposase and inactivated derivatives
IPT68_RS00295	COG1404	Belongs to the peptidase S8 family
IPT68_RS00320	COG3903	Transcriptional regulator
IPT68_RS00320	COG3629	intracellular signal transduction
IPT68_RS00360	COG2217	Heavy metal translocating P-type atpase
IPT68_RS00365	COG1937	Protein conserved in bacteria
IPT68_RS00370	COG1937	Protein conserved in bacteria
IPT68_RS00445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPT68_RS00450	COG2318	DinB family
IPT68_RS00455	COG1404	Belongs to the peptidase S8 family
IPT68_RS00470	COG0395	ABC-type sugar transport system, permease component
IPT68_RS00475	COG1175	transmembrane transport
IPT68_RS00480	COG1653	transport
IPT68_RS00490	COG2188	Transcriptional regulator
IPT68_RS00495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPT68_RS00495	COG1017	nitric oxide dioxygenase activity
IPT68_RS00620	COG3409	Peptidoglycan-binding domain 1 protein
IPT68_RS00640	COG3293	Transposase
IPT68_RS00650	COG0667	Aldo Keto reductase
IPT68_RS00665	COG0726	polysaccharide deacetylase
IPT68_RS00675	COG1959	2 iron, 2 sulfur cluster binding
IPT68_RS00680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPT68_RS00685	COG4221	oxidoreductase activity
IPT68_RS00745	COG1126	abc transporter atp-binding protein
IPT68_RS00765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPT68_RS00780	COG0589	response to stress
IPT68_RS00795	COG1937	Protein conserved in bacteria
IPT68_RS00800	COG0730	response to heat
IPT68_RS00810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPT68_RS00810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPT68_RS00855	COG2207	Transcriptional regulator
IPT68_RS00855	COG3708	Transcriptional regulator
IPT68_RS00860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPT68_RS00860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPT68_RS00875	COG1554	hydrolase, family 65, central catalytic
IPT68_RS00890	COG1653	transport
IPT68_RS00925	COG0672	)-iron permease
IPT68_RS00930	COG2837	iron assimilation
IPT68_RS00935	COG0154	amidase activity
IPT68_RS00950	COG1216	Glycosyl transferase, family 2
IPT68_RS00950	COG1442	glycosyl transferase family 8
IPT68_RS00965	COG1609	Transcriptional regulator
IPT68_RS00975	COG1175	transmembrane transport
IPT68_RS00980	COG0395	ABC-type sugar transport system, permease component
IPT68_RS00990	COG1501	Belongs to the glycosyl hydrolase 31 family
IPT68_RS01015	COG2208	phosphoserine phosphatase activity
IPT68_RS01015	COG2770	Histidine kinase
IPT68_RS01035	COG4552	Acetyltransferase involved in intracellular survival and related
IPT68_RS01050	COG0655	NAD(P)H dehydrogenase (quinone) activity
IPT68_RS01060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS01070	COG0604	alcohol dehydrogenase
IPT68_RS01075	COG1595	DNA-templated transcription, initiation
IPT68_RS01090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPT68_RS01095	COG0569	domain protein
IPT68_RS01110	COG4109	DRTGG domain
IPT68_RS01115	COG1063	alcohol dehydrogenase
IPT68_RS01165	COG0517	IMP dehydrogenase activity
IPT68_RS01165	COG0516	GMP reductase activity
IPT68_RS01300	COG3383	formate dehydrogenase (NAD+) activity
IPT68_RS01305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPT68_RS01370	COG1796	DNA polymerase
IPT68_RS01370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPT68_RS01380	COG0517	IMP dehydrogenase activity
IPT68_RS01380	COG0516	GMP reductase activity
IPT68_RS01395	COG0205	6-phosphofructokinase activity
IPT68_RS01405	COG1830	Aldolase
IPT68_RS01410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPT68_RS01415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPT68_RS01420	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS01420	COG0022	dehydrogenase e1 component
IPT68_RS01425	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS01450	COG1269	ATP hydrolysis coupled proton transport
IPT68_RS01470	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IPT68_RS01475	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IPT68_RS01490	COG1178	ABC-type Fe3 transport system permease component
IPT68_RS01495	COG3842	ATPase activity
IPT68_RS01510	COG2308	Evidence 4 Homologs of previously reported genes of
IPT68_RS01510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPT68_RS01560	COG1136	(ABC) transporter
IPT68_RS01565	COG3851	Histidine kinase
IPT68_RS01570	COG2197	response regulator
IPT68_RS01575	COG2409	Drug exporters of the RND superfamily
IPT68_RS01620	COG1175	transmembrane transport
IPT68_RS01635	COG3250	beta-galactosidase activity
IPT68_RS01660	COG2084	Dehydrogenase
IPT68_RS01700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IPT68_RS01705	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IPT68_RS01715	COG1802	Transcriptional regulator
IPT68_RS01725	COG0022	dehydrogenase e1 component
IPT68_RS01730	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS01740	COG0006	proline dipeptidase activity
IPT68_RS01750	COG1819	glycosyl
IPT68_RS01785	COG1063	alcohol dehydrogenase
IPT68_RS01800	COG0395	ABC-type sugar transport system, permease component
IPT68_RS01805	COG1940	carbohydrate kinase activity
IPT68_RS01830	COG1309	transcriptional regulator
IPT68_RS01850	COG2085	NADP oxidoreductase coenzyme F420-dependent
IPT68_RS01895	COG0745	RESPONSE REGULATOR receiver
IPT68_RS01900	COG2205	protein histidine kinase activity
IPT68_RS01915	COG2197	response regulator
IPT68_RS01920	COG4585	Histidine kinase
IPT68_RS01975	COG2608	mercury ion transmembrane transporter activity
IPT68_RS02165	COG0494	nUDIX hydrolase
IPT68_RS02170	COG2226	methyltransferase
IPT68_RS02180	COG2259	Doxx family
IPT68_RS02190	COG0513	Belongs to the DEAD box helicase family
IPT68_RS02195	COG1278	Cold shock
IPT68_RS02230	COG0640	Transcriptional regulator
IPT68_RS02235	COG0346	lactoylglutathione lyase activity
IPT68_RS02290	COG0753	catalase activity
IPT68_RS02295	COG4977	sequence-specific DNA binding
IPT68_RS02340	COG1819	glycosyl
IPT68_RS02420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPT68_RS02425	COG0492	ferredoxin-NADP+ reductase activity
IPT68_RS02440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPT68_RS02455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPT68_RS02455	COG0473	3-isopropylmalate dehydrogenase activity
IPT68_RS02495	COG2132	Multicopper oxidase
IPT68_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS02540	COG2124	cytochrome p450
IPT68_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS02580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPT68_RS02595	COG0748	coenzyme F420 binding
IPT68_RS02635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPT68_RS02635	COG0723	plastoquinol--plastocyanin reductase activity
IPT68_RS02660	COG3290	protein histidine kinase activity
IPT68_RS02680	COG0009	L-threonylcarbamoyladenylate synthase
IPT68_RS02685	COG0412	Dienelactone hydrolase
IPT68_RS02695	COG3265	gluconokinase activity
IPT68_RS02745	COG2197	response regulator
IPT68_RS02750	COG1793	dna ligase
IPT68_RS02760	COG0181	hydroxymethylbilane synthase activity
IPT68_RS02800	COG0366	Alpha amylase catalytic
IPT68_RS02810	COG3281	Trehalose synthase
IPT68_RS02815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPT68_RS02820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPT68_RS02880	COG1982	Orn Lys Arg decarboxylase major
IPT68_RS02890	COG0477	Major facilitator Superfamily
IPT68_RS02915	COG3189	MarR family transcriptional regulator
IPT68_RS02935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPT68_RS02980	COG2340	Cysteine-rich secretory protein family
IPT68_RS02990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPT68_RS02990	COG0515	serine threonine protein kinase
IPT68_RS02995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS03005	COG3647	Membrane
IPT68_RS03015	COG0667	Aldo Keto reductase
IPT68_RS03030	COG2304	oxidoreductase activity
IPT68_RS03055	COG0328	RNA-DNA hybrid ribonuclease activity
IPT68_RS03085	COG0596	Alpha beta hydrolase
IPT68_RS03090	COG0740	serine-type endopeptidase activity
IPT68_RS03095	COG0740	serine-type endopeptidase activity
IPT68_RS03100	COG1396	sequence-specific DNA binding
IPT68_RS03105	COG1191	sigma factor activity
IPT68_RS03135	COG1131	(ABC) transporter
IPT68_RS03135	COG0842	Transport permease protein
IPT68_RS03135	COG1716	ATPase activity
IPT68_RS03150	COG0667	Aldo Keto reductase
IPT68_RS03155	COG0583	DNA-binding transcription factor activity
IPT68_RS03165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPT68_RS03170	COG0346	lactoylglutathione lyase activity
IPT68_RS03180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPT68_RS03185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IPT68_RS03190	COG2080	2 iron, 2 sulfur cluster binding
IPT68_RS03220	COG1796	DNA polymerase
IPT68_RS03220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPT68_RS03260	COG0640	Transcriptional regulator
IPT68_RS03285	COG0673	inositol 2-dehydrogenase activity
IPT68_RS03340	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS03345	COG2366	antibiotic biosynthetic process
IPT68_RS03350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPT68_RS03365	COG0515	serine threonine protein kinase
IPT68_RS03400	COG2084	Dehydrogenase
IPT68_RS03440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPT68_RS03525	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPT68_RS03530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPT68_RS03540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IPT68_RS03550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPT68_RS03555	COG2376	Dihydroxyacetone kinase
IPT68_RS03560	COG1461	Dihydroxyacetone kinase
IPT68_RS03590	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPT68_RS03590	COG1902	pentaerythritol trinitrate reductase activity
IPT68_RS03610	COG2890	protein-(glutamine-N5) methyltransferase activity
IPT68_RS03615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPT68_RS03630	COG3458	cephalosporin-C deacetylase activity
IPT68_RS03640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPT68_RS03645	COG2188	Transcriptional regulator
IPT68_RS03655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IPT68_RS03660	COG1686	Belongs to the peptidase S11 family
IPT68_RS03670	COG2066	Belongs to the glutaminase family
IPT68_RS03680	COG2186	Transcriptional regulator
IPT68_RS03685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPT68_RS03690	COG1993	acr, cog1993
IPT68_RS03695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPT68_RS03700	COG0640	Transcriptional regulator
IPT68_RS03790	COG0517	IMP dehydrogenase activity
IPT68_RS03790	COG0516	GMP reductase activity
IPT68_RS03800	COG0589	response to stress
IPT68_RS03825	COG0574	Belongs to the PEP-utilizing enzyme family
IPT68_RS03825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPT68_RS03835	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IPT68_RS03845	COG1063	alcohol dehydrogenase
IPT68_RS03905	COG2188	Transcriptional regulator
IPT68_RS03910	COG3415	Transposase
IPT68_RS03910	COG2801	Transposase and inactivated derivatives
IPT68_RS03945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPT68_RS03955	COG0437	4 iron, 4 sulfur cluster binding
IPT68_RS03965	COG3383	formate dehydrogenase (NAD+) activity
IPT68_RS03965	COG0243	molybdopterin cofactor binding
IPT68_RS03970	COG0243	molybdopterin cofactor binding
IPT68_RS03970	COG3383	formate dehydrogenase (NAD+) activity
IPT68_RS03975	COG0709	Synthesizes selenophosphate from selenide and ATP
IPT68_RS03995	COG2340	Cysteine-rich secretory protein family
IPT68_RS04005	COG1595	DNA-templated transcription, initiation
IPT68_RS04025	COG1595	DNA-templated transcription, initiation
IPT68_RS04050	COG1335	isochorismatase
IPT68_RS04055	COG3619	membrane
IPT68_RS04060	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IPT68_RS04095	COG0640	Transcriptional regulator
IPT68_RS04100	COG1846	Transcriptional regulator
IPT68_RS04120	COG1053	succinate dehydrogenase
IPT68_RS04130	COG0778	Nitroreductase
IPT68_RS04175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPT68_RS04180	COG0477	Major facilitator Superfamily
IPT68_RS04200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPT68_RS04225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPT68_RS04240	COG1764	response to oxidative stress
IPT68_RS04250	COG1053	succinate dehydrogenase
IPT68_RS04270	COG1595	DNA-templated transcription, initiation
IPT68_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS04340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPT68_RS04345	COG1215	transferase activity, transferring glycosyl groups
IPT68_RS04360	COG0633	Ferredoxin
IPT68_RS04360	COG3217	Mosc domain protein beta barrel domain protein
IPT68_RS04380	COG1349	DNA-binding transcription factor activity
IPT68_RS04410	COG1940	carbohydrate kinase activity
IPT68_RS04420	COG2813	Specifically methylates the guanine in position
IPT68_RS04440	COG3387	PFAM Glycoside hydrolase 15-related
IPT68_RS04460	COG0714	Associated with various cellular activities
IPT68_RS04495	COG2197	response regulator
IPT68_RS04500	COG4585	Histidine kinase
IPT68_RS04515	COG0445	tRNA wobble uridine modification
IPT68_RS04525	COG1660	Displays ATPase and GTPase activities
IPT68_RS04555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPT68_RS04600	COG0584	glycerophosphoryl diester phosphodiesterase
IPT68_RS04640	COG0671	phosphoesterase, PA-phosphatase related
IPT68_RS04645	COG0546	phosphoglycolate phosphatase activity
IPT68_RS04650	COG1309	transcriptional regulator
IPT68_RS04680	COG0640	Transcriptional regulator
IPT68_RS04685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPT68_RS04700	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS04715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IPT68_RS04745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPT68_RS04765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPT68_RS04770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IPT68_RS04775	COG2080	2 iron, 2 sulfur cluster binding
IPT68_RS04785	COG2124	cytochrome p450
IPT68_RS04855	COG2072	flavoprotein involved in K transport
IPT68_RS04860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPT68_RS04865	COG1132	(ABC) transporter
IPT68_RS04875	COG1132	(ABC) transporter
IPT68_RS04880	COG1132	(ABC) transporter
IPT68_RS04890	COG0254	rRNA binding
IPT68_RS04905	COG1946	Acyl-CoA thioesterase
IPT68_RS04915	COG2018	Roadblock/LC7 domain
IPT68_RS04975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPT68_RS05000	COG1070	Carbohydrate kinase
IPT68_RS05005	COG1846	Transcriptional regulator
IPT68_RS05005	COG1940	carbohydrate kinase activity
IPT68_RS05020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPT68_RS05035	COG2192	nodulation
IPT68_RS05050	COG0859	PFAM glycosyl transferase family 9
IPT68_RS05060	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS05065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPT68_RS05070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPT68_RS05070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPT68_RS05075	COG0859	PFAM glycosyl transferase family 9
IPT68_RS05105	COG1088	dTDP-glucose 4,6-dehydratase activity
IPT68_RS05125	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS05130	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS05145	COG0492	ferredoxin-NADP+ reductase activity
IPT68_RS05150	COG1793	dna ligase
IPT68_RS05160	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS05170	COG3424	synthase
IPT68_RS05175	COG2124	cytochrome p450
IPT68_RS05185	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS05195	COG0242	peptide deformylase activity
IPT68_RS05205	COG3442	glutamine amidotransferase
IPT68_RS05210	COG0205	6-phosphofructokinase activity
IPT68_RS05225	COG3275	phosphorelay sensor kinase activity
IPT68_RS05230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPT68_RS05240	COG3279	Response regulator of the LytR AlgR family
IPT68_RS05245	COG1522	sequence-specific DNA binding
IPT68_RS05250	COG1834	amidinotransferase
IPT68_RS05255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPT68_RS05295	COG0204	Acyl-transferase
IPT68_RS05305	COG0596	Alpha beta hydrolase
IPT68_RS05310	COG0829	nickel cation binding
IPT68_RS05315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IPT68_RS05325	COG0804	urea catabolic process
IPT68_RS05330	COG0832	Belongs to the urease beta subunit family
IPT68_RS05335	COG0831	urea catabolic process
IPT68_RS05340	COG1309	transcriptional regulator
IPT68_RS05350	COG0740	serine-type endopeptidase activity
IPT68_RS05390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPT68_RS05395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPT68_RS05400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IPT68_RS05405	COG2226	methyltransferase
IPT68_RS05420	COG1136	(ABC) transporter
IPT68_RS05420	COG0577	efflux transmembrane transporter activity
IPT68_RS05425	COG0456	acetyltransferase
IPT68_RS05445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPT68_RS05455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPT68_RS05460	COG2423	ornithine cyclodeaminase activity
IPT68_RS05495	COG4585	Histidine kinase
IPT68_RS05500	COG2197	response regulator
IPT68_RS05505	COG1940	carbohydrate kinase activity
IPT68_RS05510	COG2188	Transcriptional regulator
IPT68_RS05515	COG1595	DNA-templated transcription, initiation
IPT68_RS05545	COG0626	cystathionine gamma-synthase activity
IPT68_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS05575	COG0419	ATPase involved in DNA repair
IPT68_RS05580	COG0420	3'-5' exonuclease activity
IPT68_RS05585	COG1739	Uncharacterized protein family UPF0029
IPT68_RS05600	COG1832	CoA-binding protein
IPT68_RS05610	COG0640	Transcriptional regulator
IPT68_RS05635	COG0110	maltose O-acetyltransferase activity
IPT68_RS05650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPT68_RS05695	COG0183	Belongs to the thiolase family
IPT68_RS05710	COG1968	undecaprenyl-diphosphatase activity
IPT68_RS05735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPT68_RS05755	COG2318	DinB family
IPT68_RS05770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IPT68_RS05855	COG0384	phenazine biosynthesis protein PhzF
IPT68_RS05885	COG3507	Belongs to the glycosyl hydrolase 43 family
IPT68_RS05895	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IPT68_RS05900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IPT68_RS05905	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPT68_RS05945	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPT68_RS05945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPT68_RS05955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPT68_RS05975	COG1716	ATPase activity
IPT68_RS05995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPT68_RS06025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPT68_RS06035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPT68_RS06055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPT68_RS06060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPT68_RS06080	COG2018	Roadblock/LC7 domain
IPT68_RS06115	COG2814	Major facilitator Superfamily
IPT68_RS06120	COG4336	lyase activity
IPT68_RS06125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IPT68_RS06130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IPT68_RS06135	COG1984	allophanate hydrolase subunit 2
IPT68_RS06140	COG2755	lipolytic protein G-D-S-L family
IPT68_RS06145	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS06185	COG2270	Major facilitator Superfamily
IPT68_RS06200	COG0463	Glycosyl transferase, family 2
IPT68_RS06230	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS06255	COG0572	uridine kinase
IPT68_RS06280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPT68_RS06285	COG0140	phosphoribosyl-ATP diphosphatase activity
IPT68_RS06290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPT68_RS06295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPT68_RS06295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPT68_RS06300	COG3201	nicotinamide mononucleotide transporter
IPT68_RS06320	COG1940	carbohydrate kinase activity
IPT68_RS06320	COG1846	Transcriptional regulator
IPT68_RS06325	COG0738	Major facilitator superfamily
IPT68_RS06330	COG2233	PERMEase
IPT68_RS06355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPT68_RS06385	COG2390	Transcriptional regulator
IPT68_RS06390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPT68_RS06400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPT68_RS06415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPT68_RS06425	COG1758	RNA polymerase activity
IPT68_RS06430	COG0194	GDP metabolic process
IPT68_RS06440	COG0284	orotidine-5'-phosphate decarboxylase activity
IPT68_RS06445	COG0167	dihydroorotate dehydrogenase activity
IPT68_RS06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPT68_RS06455	COG0505	Belongs to the CarA family
IPT68_RS06465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPT68_RS06470	COG0540	Belongs to the ATCase OTCase family
IPT68_RS06475	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPT68_RS06485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPT68_RS06490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPT68_RS06495	COG0006	proline dipeptidase activity
IPT68_RS06505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPT68_RS06510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPT68_RS06515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPT68_RS06520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPT68_RS06525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPT68_RS06530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPT68_RS06535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPT68_RS06555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPT68_RS06570	COG0124	histidyl-tRNA synthetase
IPT68_RS06580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPT68_RS06585	COG1196	nuclear chromosome segregation
IPT68_RS06590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPT68_RS06595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPT68_RS06600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPT68_RS06605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPT68_RS06615	COG2255	four-way junction helicase activity
IPT68_RS06620	COG0632	four-way junction helicase activity
IPT68_RS06625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPT68_RS06630	COG0217	transcriptional regulatory protein
IPT68_RS06635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPT68_RS06640	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPT68_RS06650	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS06655	COG1560	Kdo2-lipid A biosynthetic process
IPT68_RS06660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPT68_RS06680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPT68_RS06695	COG5002	protein histidine kinase activity
IPT68_RS06695	COG2176	DNA-directed DNA polymerase activity
IPT68_RS06770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPT68_RS06825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPT68_RS06825	COG1648	precorrin-2 dehydrogenase activity
IPT68_RS06830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IPT68_RS06850	COG2011	ABC-type metal ion transport system permease component
IPT68_RS06855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPT68_RS06860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPT68_RS06885	COG0584	glycerophosphoryl diester phosphodiesterase
IPT68_RS06890	COG0204	Acyl-transferase
IPT68_RS06890	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS06895	COG0477	Major facilitator Superfamily
IPT68_RS06910	COG0165	Argininosuccinate lyase
IPT68_RS06915	COG0137	argininosuccinate synthase activity
IPT68_RS06935	COG1017	nitric oxide dioxygenase activity
IPT68_RS06935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPT68_RS06950	COG2264	protein methyltransferase activity
IPT68_RS06955	COG0789	Transcriptional regulator
IPT68_RS06960	COG1438	arginine binding
IPT68_RS06965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPT68_RS06970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPT68_RS06975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IPT68_RS06980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IPT68_RS07010	COG0697	spore germination
IPT68_RS07020	COG1649	PFAM Uncharacterised BCR, COG1649
IPT68_RS07050	COG0072	phenylalanine-tRNA ligase activity
IPT68_RS07050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPT68_RS07055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPT68_RS07060	COG5002	protein histidine kinase activity
IPT68_RS07065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPT68_RS07070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPT68_RS07075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPT68_RS07080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPT68_RS07125	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS07130	COG0174	glutamine synthetase
IPT68_RS07135	COG2186	Transcriptional regulator
IPT68_RS07140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPT68_RS07155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPT68_RS07165	COG4176	ABC-type proline glycine betaine transport system permease component
IPT68_RS07170	COG0517	IMP dehydrogenase activity
IPT68_RS07170	COG4175	Glycine betaine
IPT68_RS07175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPT68_RS07225	COG0805	protein transport
IPT68_RS07230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPT68_RS07260	COG0545	Peptidyl-prolyl cis-trans isomerase
IPT68_RS07265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPT68_RS07275	COG1609	Transcriptional regulator
IPT68_RS07280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPT68_RS07285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPT68_RS07300	COG4122	O-methyltransferase activity
IPT68_RS07305	COG1222	aaa ATPase
IPT68_RS07325	COG1994	Peptidase M50
IPT68_RS07325	COG0517	IMP dehydrogenase activity
IPT68_RS07335	COG2197	response regulator
IPT68_RS07340	COG4166	transmembrane transport
IPT68_RS07350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPT68_RS07355	COG0646	methionine synthase
IPT68_RS07355	COG1410	methionine synthase
IPT68_RS07360	COG1414	Transcriptional regulator
IPT68_RS07365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPT68_RS07370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPT68_RS07375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPT68_RS07390	COG0215	cysteine-tRNA ligase activity
IPT68_RS07405	COG0588	phosphoglycerate mutase activity
IPT68_RS07410	COG0598	Magnesium transport protein CorA
IPT68_RS07420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS07425	COG0667	Aldo Keto reductase
IPT68_RS07455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPT68_RS07470	COG0308	aminopeptidase N
IPT68_RS07480	COG0667	Aldo Keto reductase
IPT68_RS07485	COG3012	SEC-C Motif Domain Protein
IPT68_RS07490	COG2186	Transcriptional regulator
IPT68_RS07495	COG3265	gluconokinase activity
IPT68_RS07510	COG2186	Transcriptional regulator
IPT68_RS07525	COG4948	Mandelate Racemase Muconate Lactonizing
IPT68_RS07530	COG0395	ABC-type sugar transport system, permease component
IPT68_RS07535	COG1175	transmembrane transport
IPT68_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS07555	COG1063	alcohol dehydrogenase
IPT68_RS07585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPT68_RS07590	COG2149	membrane
IPT68_RS07620	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS07630	COG3876	Protein conserved in bacteria
IPT68_RS07650	COG0789	Transcriptional regulator
IPT68_RS07670	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS07720	COG2851	Citrate transporter
IPT68_RS07725	COG0243	molybdopterin cofactor binding
IPT68_RS07730	COG1309	transcriptional regulator
IPT68_RS07740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IPT68_RS07745	COG2188	Transcriptional regulator
IPT68_RS07755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPT68_RS07770	COG1595	DNA-templated transcription, initiation
IPT68_RS07790	COG2815	serine threonine protein kinase
IPT68_RS07790	COG0515	serine threonine protein kinase
IPT68_RS07795	COG2755	lipolytic protein G-D-S-L family
IPT68_RS07815	COG1216	Glycosyl transferase, family 2
IPT68_RS07845	COG1725	Transcriptional regulator
IPT68_RS07860	COG2226	methyltransferase
IPT68_RS07880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPT68_RS07885	COG0587	DNA-directed DNA polymerase activity
IPT68_RS07905	COG1799	cell septum assembly
IPT68_RS07910	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS07915	COG0477	Major facilitator Superfamily
IPT68_RS07925	COG0671	phosphoesterase, PA-phosphatase related
IPT68_RS07940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPT68_RS07940	COG2755	lipolytic protein G-D-S-L family
IPT68_RS07950	COG1652	LysM domain
IPT68_RS07965	COG1160	GTP binding
IPT68_RS07975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPT68_RS07995	COG1056	cytidyltransferase-related domain
IPT68_RS07995	COG1051	belongs to the nudix hydrolase family
IPT68_RS08010	COG1187	pseudouridine synthase activity
IPT68_RS08015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPT68_RS08020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPT68_RS08035	COG0686	Belongs to the AlaDH PNT family
IPT68_RS08045	COG0494	nUDIX hydrolase
IPT68_RS08050	COG0504	CTP synthase activity
IPT68_RS08055	COG3387	PFAM Glycoside hydrolase 15-related
IPT68_RS08085	COG0497	DNA recombination
IPT68_RS08090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPT68_RS08110	COG1120	ATPase activity
IPT68_RS08115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPT68_RS08120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPT68_RS08125	COG0647	UMP catabolic process
IPT68_RS08180	COG1881	PFAM PEBP family protein
IPT68_RS08200	COG1119	ATPase activity
IPT68_RS08215	COG2197	response regulator
IPT68_RS08220	COG4585	Histidine kinase
IPT68_RS08225	COG4221	oxidoreductase activity
IPT68_RS08230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPT68_RS08240	COG0842	Transport permease protein
IPT68_RS08240	COG1131	(ABC) transporter
IPT68_RS08240	COG1716	ATPase activity
IPT68_RS08250	COG3830	Belongs to the UPF0237 family
IPT68_RS08250	COG0560	Phosphoserine phosphatase
IPT68_RS08255	COG0588	phosphoglycerate mutase activity
IPT68_RS08270	COG2186	Transcriptional regulator
IPT68_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS08290	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPT68_RS08305	COG1401	restriction endodeoxyribonuclease activity
IPT68_RS08340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPT68_RS08345	COG1111	helicase
IPT68_RS08345	COG1205	dead DEAH box helicase
IPT68_RS08360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPT68_RS08380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPT68_RS08385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPT68_RS08415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPT68_RS08430	COG3387	PFAM Glycoside hydrolase 15-related
IPT68_RS08480	COG0488	(ABC) transporter
IPT68_RS08505	COG0235	Class ii aldolase
IPT68_RS08520	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IPT68_RS08525	COG1492	cobalamin metabolic process
IPT68_RS08545	COG1797	cobyrinic acid a,c-diamide synthase activity
IPT68_RS08580	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IPT68_RS08610	COG0765	amino acid transport
IPT68_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPT68_RS08620	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IPT68_RS08625	COG2318	DinB family
IPT68_RS08630	COG0456	acetyltransferase
IPT68_RS08635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPT68_RS08640	COG1917	Cupin 2, conserved barrel domain protein
IPT68_RS08645	COG5285	phytanoyl-CoA dioxygenase
IPT68_RS08695	COG1414	Transcriptional regulator
IPT68_RS08705	COG2252	PERMEase
IPT68_RS08725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPT68_RS08730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPT68_RS08735	COG1349	DNA-binding transcription factor activity
IPT68_RS08750	COG0395	ABC-type sugar transport system, permease component
IPT68_RS08755	COG1063	alcohol dehydrogenase
IPT68_RS08765	COG1309	transcriptional regulator
IPT68_RS08810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPT68_RS08830	COG2171	N-acyltransferase activity
IPT68_RS08835	COG2151	metal-sulfur cluster biosynthetic enzyme
IPT68_RS08840	COG0822	iron-sulfur transferase activity
IPT68_RS08845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPT68_RS08850	COG0396	ATPase activity
IPT68_RS08860	COG0719	Fe-S assembly protein
IPT68_RS08880	COG1131	(ABC) transporter
IPT68_RS08890	COG1612	heme a metabolic process
IPT68_RS08910	COG0109	protoheme IX farnesyltransferase activity
IPT68_RS08920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPT68_RS08940	COG0395	ABC-type sugar transport system, permease component
IPT68_RS08945	COG1175	transmembrane transport
IPT68_RS08950	COG1653	transport
IPT68_RS08955	COG0366	Alpha amylase catalytic
IPT68_RS08960	COG1653	transport
IPT68_RS08965	COG1695	Transcriptional regulator
IPT68_RS08970	COG1136	(ABC) transporter
IPT68_RS08985	COG0166	Belongs to the GPI family
IPT68_RS08995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPT68_RS09000	COG0149	triose-phosphate isomerase activity
IPT68_RS09005	COG0126	phosphoglycerate kinase activity
IPT68_RS09010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPT68_RS09020	COG1481	regulation of sporulation
IPT68_RS09025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPT68_RS09030	COG1660	Displays ATPase and GTPase activities
IPT68_RS09035	COG0322	excinuclease ABC activity
IPT68_RS09045	COG1609	Transcriptional regulator
IPT68_RS09055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPT68_RS09070	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IPT68_RS09075	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPT68_RS09080	COG0477	Major facilitator Superfamily
IPT68_RS09085	COG0387	Pfam Sodium calcium exchanger
IPT68_RS09105	COG0556	nucleotide-excision repair
IPT68_RS09120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPT68_RS09130	COG2313	pseudouridylate synthase activity
IPT68_RS09140	COG2226	methyltransferase
IPT68_RS09145	COG0598	Magnesium transport protein CorA
IPT68_RS09180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS09185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPT68_RS09215	COG1132	(ABC) transporter
IPT68_RS09250	COG1136	(ABC) transporter
IPT68_RS09270	COG0251	oxidation-reduction process
IPT68_RS09295	COG2226	methyltransferase
IPT68_RS09310	COG0237	dephospho-CoA kinase activity
IPT68_RS09320	COG0539	negative regulation of cytoplasmic translation
IPT68_RS09325	COG2226	methyltransferase
IPT68_RS09330	COG1643	Atp-dependent helicase
IPT68_RS09360	COG2050	protein possibly involved in aromatic compounds catabolism
IPT68_RS09420	COG0737	Belongs to the 5'-nucleotidase family
IPT68_RS09440	COG4566	intracellular signal transduction
IPT68_RS09445	COG1605	Chorismate mutase
IPT68_RS09445	COG0287	Prephenate dehydrogenase
IPT68_RS09460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPT68_RS09465	COG2304	oxidoreductase activity
IPT68_RS09475	COG0069	glutamate synthase activity
IPT68_RS09475	COG0070	glutamate synthase
IPT68_RS09475	COG0067	glutamate synthase
IPT68_RS09505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPT68_RS09515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPT68_RS09525	COG0159	tryptophan synthase activity
IPT68_RS09530	COG0133	tryptophan synthase activity
IPT68_RS09540	COG0134	indole-3-glycerol-phosphate synthase activity
IPT68_RS09565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPT68_RS09575	COG0107	imidazoleglycerol-phosphate synthase activity
IPT68_RS09580	COG0251	oxidation-reduction process
IPT68_RS09585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPT68_RS09590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPT68_RS09600	COG0131	Imidazoleglycerol-phosphate dehydratase
IPT68_RS09605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPT68_RS09610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPT68_RS09625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPT68_RS09645	COG1432	Conserved Protein
IPT68_RS09655	COG0587	DNA-directed DNA polymerase activity
IPT68_RS09720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPT68_RS09730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPT68_RS09735	COG3599	regulation of cell shape
IPT68_RS09745	COG1799	cell septum assembly
IPT68_RS09755	COG1496	oxidoreductase activity
IPT68_RS09760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPT68_RS09765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPT68_RS09770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPT68_RS09780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPT68_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPT68_RS09795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPT68_RS09800	COG0768	penicillin binding
IPT68_RS09810	COG0275	rRNA processing
IPT68_RS09820	COG0714	Associated with various cellular activities
IPT68_RS09840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPT68_RS09850	COG1121	(ABC) transporter
IPT68_RS09855	COG1511	domain protein
IPT68_RS09860	COG1309	transcriptional regulator
IPT68_RS09880	COG0352	thiamine-phosphate diphosphorylase activity
IPT68_RS09900	COG2022	thiamine diphosphate biosynthetic process
IPT68_RS09900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPT68_RS09910	COG2022	thiamine diphosphate biosynthetic process
IPT68_RS09915	COG2815	serine threonine protein kinase
IPT68_RS09915	COG0515	serine threonine protein kinase
IPT68_RS09920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPT68_RS09925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPT68_RS09930	COG2193	ferroxidase activity
IPT68_RS09935	COG0243	molybdopterin cofactor binding
IPT68_RS09940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IPT68_RS09955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPT68_RS09960	COG0205	6-phosphofructokinase activity
IPT68_RS09995	COG1940	carbohydrate kinase activity
IPT68_RS10005	COG0003	Pfam Anion-transporting ATPase
IPT68_RS10055	COG0791	NLP P60 protein
IPT68_RS10055	COG3883	PFAM NLP P60 protein
IPT68_RS10085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPT68_RS10085	COG0515	serine threonine protein kinase
IPT68_RS10090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPT68_RS10095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPT68_RS10100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPT68_RS10105	COG0723	plastoquinol--plastocyanin reductase activity
IPT68_RS10110	COG2010	Cytochrome c
IPT68_RS10115	COG1845	cytochrome c oxidase, subunit III
IPT68_RS10125	COG1376	ErfK ybiS ycfS ynhG family protein
IPT68_RS10135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPT68_RS10140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPT68_RS10150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS10170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IPT68_RS10175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPT68_RS10180	COG2197	response regulator
IPT68_RS10185	COG4585	Histidine kinase
IPT68_RS10205	COG2226	methyltransferase
IPT68_RS10210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPT68_RS10230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IPT68_RS10240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IPT68_RS10260	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS10270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPT68_RS10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPT68_RS10295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPT68_RS10345	COG0321	lipoyl(octanoyl) transferase activity
IPT68_RS10350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPT68_RS10385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPT68_RS10390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPT68_RS10420	COG0174	glutamine synthetase
IPT68_RS10435	COG0501	Belongs to the peptidase M48B family
IPT68_RS10480	COG0745	RESPONSE REGULATOR receiver
IPT68_RS10490	COG4585	Histidine kinase
IPT68_RS10495	COG2197	response regulator
IPT68_RS10515	COG1309	transcriptional regulator
IPT68_RS10535	COG0366	Alpha amylase catalytic
IPT68_RS10540	COG3833	ABC-type maltose transport systems, permease component
IPT68_RS10555	COG1609	Transcriptional regulator
IPT68_RS10565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IPT68_RS10585	COG1136	(ABC) transporter
IPT68_RS10605	COG0745	RESPONSE REGULATOR receiver
IPT68_RS10610	COG2205	protein histidine kinase activity
IPT68_RS10620	COG0596	Alpha beta hydrolase
IPT68_RS10625	COG0174	glutamine synthetase
IPT68_RS10630	COG1017	nitric oxide dioxygenase activity
IPT68_RS10630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPT68_RS10635	COG1959	2 iron, 2 sulfur cluster binding
IPT68_RS10650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPT68_RS10650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPT68_RS10655	COG2814	Major facilitator Superfamily
IPT68_RS10670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPT68_RS10690	COG1994	Peptidase M50
IPT68_RS10775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPT68_RS10780	COG2814	Major facilitator Superfamily
IPT68_RS10790	COG3540	Alkaline phosphatase
IPT68_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS10800	COG0667	Aldo Keto reductase
IPT68_RS10810	COG2259	Doxx family
IPT68_RS10825	COG0514	ATP-dependent DNA helicase (RecQ)
IPT68_RS10930	COG0252	asparaginase activity
IPT68_RS11020	COG3022	response to hydroperoxide
IPT68_RS11025	COG0800	Aldolase
IPT68_RS11040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IPT68_RS11075	COG0477	Major facilitator Superfamily
IPT68_RS11085	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPT68_RS11085	COG2247	cell wall binding repeat
IPT68_RS11120	COG1309	transcriptional regulator
IPT68_RS11130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IPT68_RS11135	COG1657	PFAM Prenyltransferase squalene oxidase
IPT68_RS11150	COG3845	ABC transporter
IPT68_RS11165	COG2326	polyphosphate kinase activity
IPT68_RS11175	COG4122	O-methyltransferase activity
IPT68_RS11255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IPT68_RS11335	COG1358	cellular component organization or biogenesis
IPT68_RS11380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPT68_RS11385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPT68_RS11395	COG0477	Major facilitator Superfamily
IPT68_RS11400	COG1309	transcriptional regulator
IPT68_RS11415	COG0667	Aldo Keto reductase
IPT68_RS11420	COG0789	Transcriptional regulator
IPT68_RS11430	COG1741	Belongs to the pirin family
IPT68_RS11445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPT68_RS11450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPT68_RS11455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPT68_RS11480	COG1309	transcriptional regulator
IPT68_RS11510	COG1764	response to oxidative stress
IPT68_RS11515	COG2130	NADP-dependent
IPT68_RS11545	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS11590	COG4214	carbohydrate transport
IPT68_RS11600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPT68_RS11610	COG1595	DNA-templated transcription, initiation
IPT68_RS11625	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IPT68_RS11630	COG2409	Drug exporters of the RND superfamily
IPT68_RS11635	COG1846	Transcriptional regulator
IPT68_RS11640	COG0702	epimerase
IPT68_RS11650	COG3046	protein related to deoxyribodipyrimidine photolyase
IPT68_RS11655	COG0142	geranyltranstransferase activity
IPT68_RS11705	COG3386	PFAM SMP-30 Gluconolaconase
IPT68_RS11710	COG1414	Transcriptional regulator
IPT68_RS11735	COG4981	capsule polysaccharide biosynthetic process
IPT68_RS11755	COG2835	tetraacyldisaccharide 4'-kinase activity
IPT68_RS11780	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS11785	COG0825	malonyl-CoA metabolic process
IPT68_RS11785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPT68_RS11790	COG1077	Cell shape determining protein MreB Mrl
IPT68_RS11830	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPT68_RS11855	COG1070	Carbohydrate kinase
IPT68_RS11870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPT68_RS11875	COG0358	DNA primase activity
IPT68_RS11885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IPT68_RS11895	COG2949	membrane
IPT68_RS11900	COG0243	molybdopterin cofactor binding
IPT68_RS11925	COG2814	Major facilitator Superfamily
IPT68_RS11935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IPT68_RS11940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IPT68_RS11940	COG2146	nitrite reductase [NAD(P)H] activity
IPT68_RS11980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPT68_RS11985	COG0574	Belongs to the PEP-utilizing enzyme family
IPT68_RS11985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPT68_RS11990	COG1846	Transcriptional regulator
IPT68_RS11990	COG1940	carbohydrate kinase activity
IPT68_RS11995	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IPT68_RS12030	COG0667	Aldo Keto reductase
IPT68_RS12040	COG0423	glycine-tRNA ligase activity
IPT68_RS12045	COG0803	Belongs to the bacterial solute-binding protein 9 family
IPT68_RS12045	COG3443	Belongs to the bacterial solute-binding protein 9 family
IPT68_RS12050	COG1121	(ABC) transporter
IPT68_RS12055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPT68_RS12075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPT68_RS12080	COG1381	Involved in DNA repair and RecF pathway recombination
IPT68_RS12100	COG0747	negative chemotaxis
IPT68_RS12110	COG0444	Belongs to the ABC transporter superfamily
IPT68_RS12115	COG4608	Belongs to the ABC transporter superfamily
IPT68_RS12120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPT68_RS12135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPT68_RS12150	COG2723	6-phospho-beta-galactosidase activity
IPT68_RS12160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPT68_RS12170	COG2315	Protein conserved in bacteria
IPT68_RS12180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPT68_RS12190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS12195	COG4948	Mandelate Racemase Muconate Lactonizing
IPT68_RS12210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPT68_RS12215	COG1234	tRNA 3'-trailer cleavage
IPT68_RS12220	COG0537	adenosine 5'-monophosphoramidase activity
IPT68_RS12225	COG0793	Belongs to the peptidase S41A family
IPT68_RS12225	COG4946	Tricorn protease homolog
IPT68_RS12250	COG0484	heat shock protein binding
IPT68_RS12255	COG1420	regulation of RNA biosynthetic process
IPT68_RS12290	COG0481	GTPase activity
IPT68_RS12295	COG0268	Binds directly to 16S ribosomal RNA
IPT68_RS12310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IPT68_RS12320	COG1555	photosystem II stabilization
IPT68_RS12325	COG1307	EDD domain protein, DegV family
IPT68_RS12335	COG0495	leucyl-tRNA aminoacylation
IPT68_RS12345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IPT68_RS12375	COG0588	phosphoglycerate mutase activity
IPT68_RS12390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPT68_RS12405	COG0501	Belongs to the peptidase M48B family
IPT68_RS12420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IPT68_RS12430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPT68_RS12450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPT68_RS12455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPT68_RS12460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPT68_RS12465	COG1530	ribonuclease E activity
IPT68_RS12530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPT68_RS12530	COG1672	PFAM Archaeal ATPase
IPT68_RS12535	COG0596	Alpha beta hydrolase
IPT68_RS12575	COG2186	Transcriptional regulator
IPT68_RS12645	COG0772	Belongs to the SEDS family
IPT68_RS12650	COG0768	penicillin binding
IPT68_RS12665	COG1077	Cell shape determining protein MreB Mrl
IPT68_RS12670	COG0105	UTP biosynthetic process
IPT68_RS12680	COG0285	dihydrofolate synthase activity
IPT68_RS12685	COG0525	valine-tRNA ligase activity
IPT68_RS12695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPT68_RS12700	COG0740	serine-type endopeptidase activity
IPT68_RS12705	COG0740	serine-type endopeptidase activity
IPT68_RS12710	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPT68_RS12730	COG3594	Acyltransferase
IPT68_RS12810	COG4552	Acetyltransferase involved in intracellular survival and related
IPT68_RS12825	COG1113	amino acid transport
IPT68_RS12830	COG0515	serine threonine protein kinase
IPT68_RS12840	COG1268	BioY protein
IPT68_RS12845	COG1113	amino acid transport
IPT68_RS12860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IPT68_RS12920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPT68_RS12950	COG1136	(ABC) transporter
IPT68_RS12965	COG0668	transmembrane transport
IPT68_RS12985	COG1486	melibiose metabolic process
IPT68_RS13000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPT68_RS13030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPT68_RS13035	COG2346	COG2346, Truncated hemoglobins
IPT68_RS13065	COG0629	single-stranded DNA binding
IPT68_RS13085	COG2188	Transcriptional regulator
IPT68_RS13190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPT68_RS13275	COG2318	DinB family
IPT68_RS13285	COG3962	Belongs to the TPP enzyme family
IPT68_RS13290	COG3718	enzyme involved in inositol metabolism
IPT68_RS13300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS13310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPT68_RS13335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPT68_RS13345	COG1129	ABC transporter
IPT68_RS13350	COG1879	ABC-type sugar transport system periplasmic component
IPT68_RS13355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS13360	COG1869	D-ribose catabolic process
IPT68_RS13375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IPT68_RS13385	COG1595	DNA-templated transcription, initiation
IPT68_RS13390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS13405	COG0673	inositol 2-dehydrogenase activity
IPT68_RS13425	COG1846	Transcriptional regulator
IPT68_RS13425	COG0456	acetyltransferase
IPT68_RS13440	COG1472	Belongs to the glycosyl hydrolase 3 family
IPT68_RS13475	COG2356	endonuclease I
IPT68_RS13515	COG0028	Belongs to the TPP enzyme family
IPT68_RS13525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPT68_RS13540	COG1946	Acyl-CoA thioesterase
IPT68_RS13555	COG1309	transcriptional regulator
IPT68_RS13560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPT68_RS13575	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS13610	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IPT68_RS13645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPT68_RS13655	COG0589	response to stress
IPT68_RS13665	COG4977	sequence-specific DNA binding
IPT68_RS13670	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IPT68_RS13700	COG0395	ABC-type sugar transport system, permease component
IPT68_RS13715	COG0745	RESPONSE REGULATOR receiver
IPT68_RS13745	COG0406	alpha-ribazole phosphatase activity
IPT68_RS13795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS13810	COG2186	Transcriptional regulator
IPT68_RS13855	COG0673	inositol 2-dehydrogenase activity
IPT68_RS13860	COG4702	Belongs to the UPF0303 family
IPT68_RS13975	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPT68_RS14005	COG0596	Alpha beta hydrolase
IPT68_RS14015	COG2733	membrane
IPT68_RS14030	COG4555	ABC transporter
IPT68_RS14045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPT68_RS14075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPT68_RS14085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPT68_RS14090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPT68_RS14095	COG1263	PTS System
IPT68_RS14100	COG1263	PTS System
IPT68_RS14105	COG1234	tRNA 3'-trailer cleavage
IPT68_RS14130	COG1113	amino acid transport
IPT68_RS14140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPT68_RS14150	COG1335	isochorismatase
IPT68_RS14185	COG0277	FAD linked oxidase domain protein
IPT68_RS14195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPT68_RS14215	COG1174	glycine betaine transport
IPT68_RS14250	COG3654	unkown
IPT68_RS14270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPT68_RS14285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IPT68_RS14305	COG1678	Uncharacterized ACR, COG1678
IPT68_RS14310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPT68_RS14315	COG0776	regulation of translation
IPT68_RS14325	COG3973	AAA domain
IPT68_RS14355	COG2223	nitrite transmembrane transporter activity
IPT68_RS14380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPT68_RS14385	COG0793	Belongs to the peptidase S41A family
IPT68_RS14395	COG2884	Cell division ATP-binding protein ftsE
IPT68_RS14410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPT68_RS14415	COG0515	serine threonine protein kinase
IPT68_RS14420	COG0515	serine threonine protein kinase
IPT68_RS14435	COG1175	transmembrane transport
IPT68_RS14440	COG0395	ABC-type sugar transport system, permease component
IPT68_RS14455	COG1764	response to oxidative stress
IPT68_RS14460	COG1846	Transcriptional regulator
IPT68_RS14485	COG1134	teichoic acid transport
IPT68_RS14490	COG2902	Dehydrogenase
IPT68_RS14515	COG0653	protein targeting
IPT68_RS14525	COG3214	Protein conserved in bacteria
IPT68_RS14530	COG2197	response regulator
IPT68_RS14535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPT68_RS14545	COG0823	Involved in the tonB-independent uptake of proteins
IPT68_RS14550	COG5002	protein histidine kinase activity
IPT68_RS14550	COG5000	phosphorelay sensor kinase activity
IPT68_RS14555	COG0745	RESPONSE REGULATOR receiver
IPT68_RS14560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPT68_RS14580	COG0714	Associated with various cellular activities
IPT68_RS14620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPT68_RS14625	COG0681	Belongs to the peptidase S26 family
IPT68_RS14635	COG1482	cell wall glycoprotein biosynthetic process
IPT68_RS14645	COG2835	tetraacyldisaccharide 4'-kinase activity
IPT68_RS14650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPT68_RS14655	COG1620	l-lactate permease
IPT68_RS14690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPT68_RS14695	COG0778	Nitroreductase
IPT68_RS14695	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IPT68_RS14720	COG1316	TRANSCRIPTIONal
IPT68_RS14725	COG1316	TRANSCRIPTIONal
IPT68_RS14730	COG1316	TRANSCRIPTIONal
IPT68_RS14735	COG0463	Glycosyl transferase, family 2
IPT68_RS14750	COG1316	TRANSCRIPTIONal
IPT68_RS14770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPT68_RS14800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IPT68_RS14815	COG2205	protein histidine kinase activity
IPT68_RS14820	COG0745	RESPONSE REGULATOR receiver
IPT68_RS14825	COG3104	oligopeptide transport
IPT68_RS14835	COG1366	Belongs to the anti-sigma-factor antagonist family
IPT68_RS14840	COG1191	sigma factor activity
IPT68_RS14850	COG1228	amidohydrolase
IPT68_RS14865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IPT68_RS14905	COG2986	histidine ammonia-lyase
IPT68_RS14910	COG1125	glycine betaine transport
IPT68_RS14910	COG0517	IMP dehydrogenase activity
IPT68_RS14915	COG1174	glycine betaine transport
IPT68_RS14920	COG1174	glycine betaine transport
IPT68_RS14940	COG2755	lipolytic protein G-D-S-L family
IPT68_RS14950	COG0183	Belongs to the thiolase family
IPT68_RS14985	COG0577	efflux transmembrane transporter activity
IPT68_RS14985	COG1136	(ABC) transporter
IPT68_RS14990	COG0577	efflux transmembrane transporter activity
IPT68_RS14995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPT68_RS15000	COG1252	NADH dehydrogenase
IPT68_RS15025	COG0148	phosphopyruvate hydratase activity
IPT68_RS15035	COG1652	LysM domain
IPT68_RS15085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPT68_RS15115	COG0577	efflux transmembrane transporter activity
IPT68_RS15120	COG1136	(ABC) transporter
IPT68_RS15125	COG2814	Major facilitator Superfamily
IPT68_RS15135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPT68_RS15165	COG4585	Histidine kinase
IPT68_RS15180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPT68_RS15185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPT68_RS15190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPT68_RS15195	COG0193	aminoacyl-tRNA hydrolase activity
IPT68_RS15210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IPT68_RS15220	COG1309	transcriptional regulator
IPT68_RS15230	COG4106	trans-aconitate 2-methyltransferase activity
IPT68_RS15240	COG2197	response regulator
IPT68_RS15250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IPT68_RS15290	COG0488	(ABC) transporter
IPT68_RS15295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPT68_RS15300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPT68_RS15310	COG0084	hydrolase, TatD family'
IPT68_RS15335	COG0768	penicillin binding
IPT68_RS15350	COG0310	cobalt ion transport
IPT68_RS15360	COG1122	ATPase activity
IPT68_RS15365	COG1764	response to oxidative stress
IPT68_RS15390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPT68_RS15395	COG0736	holo-[acyl-carrier-protein] synthase activity
IPT68_RS15400	COG0604	alcohol dehydrogenase
IPT68_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS15400	COG3321	synthase
IPT68_RS15410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPT68_RS15430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPT68_RS15455	COG4770	biotin carboxylase activity
IPT68_RS15490	COG0475	glutathione-regulated potassium exporter activity
IPT68_RS15530	COG0745	RESPONSE REGULATOR receiver
IPT68_RS15570	COG0442	prolyl-tRNA aminoacylation
IPT68_RS15590	COG2409	Drug exporters of the RND superfamily
IPT68_RS15600	COG4946	Tricorn protease homolog
IPT68_RS15600	COG0793	Belongs to the peptidase S41A family
IPT68_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS15615	COG2267	carboxylic ester hydrolase activity
IPT68_RS15620	COG2072	flavoprotein involved in K transport
IPT68_RS15630	COG0708	Exodeoxyribonuclease III
IPT68_RS15650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPT68_RS15655	COG0315	cyclic pyranopterin monophosphate synthase activity
IPT68_RS15655	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPT68_RS15660	COG0315	cyclic pyranopterin monophosphate synthase activity
IPT68_RS15670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPT68_RS15675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IPT68_RS15690	COG0477	Major facilitator Superfamily
IPT68_RS15700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPT68_RS15725	COG3191	aminopeptidase activity
IPT68_RS15730	COG1376	ErfK ybiS ycfS ynhG family protein
IPT68_RS15740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPT68_RS15740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPT68_RS15750	COG1349	DNA-binding transcription factor activity
IPT68_RS15780	COG0477	Major facilitator Superfamily
IPT68_RS15800	COG1247	-acetyltransferase
IPT68_RS15805	COG3384	dioxygenase
IPT68_RS15810	COG1846	Transcriptional regulator
IPT68_RS15830	COG1414	Transcriptional regulator
IPT68_RS15880	COG0596	Alpha beta hydrolase
IPT68_RS15925	COG0386	Belongs to the glutathione peroxidase family
IPT68_RS15950	COG1686	Belongs to the peptidase S11 family
IPT68_RS15965	COG1397	ADP-ribosylglycohydrolase
IPT68_RS15995	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPT68_RS16055	COG0515	serine threonine protein kinase
IPT68_RS16055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPT68_RS16065	COG1309	transcriptional regulator
IPT68_RS16070	COG1522	sequence-specific DNA binding
IPT68_RS16075	COG1280	lysine exporter protein (LysE YggA)
IPT68_RS16095	COG2072	flavoprotein involved in K transport
IPT68_RS16175	COG0596	Alpha beta hydrolase
IPT68_RS16175	COG2945	thiolester hydrolase activity
IPT68_RS16185	COG4821	SIS domain
IPT68_RS16205	COG0259	pyridoxamine-phosphate oxidase activity
IPT68_RS16220	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS16235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPT68_RS16255	COG5006	permease, DMT superfamily
IPT68_RS16290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPT68_RS16310	COG0667	Aldo Keto reductase
IPT68_RS16340	COG2252	PERMEase
IPT68_RS16350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPT68_RS16370	COG2814	Major facilitator Superfamily
IPT68_RS16380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IPT68_RS16385	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPT68_RS16390	COG1278	Cold shock
IPT68_RS16435	COG1061	Type III restriction enzyme res subunit
IPT68_RS16450	COG3973	AAA domain
IPT68_RS16485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPT68_RS16490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IPT68_RS16495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPT68_RS16495	COG1263	PTS System
IPT68_RS16515	COG0459	protein refolding
IPT68_RS16520	COG1278	Cold shock
IPT68_RS16535	COG0463	Glycosyl transferase, family 2
IPT68_RS16540	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IPT68_RS16580	COG5001	Diguanylate cyclase
IPT68_RS16580	COG3300	MHYT domain
IPT68_RS16640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPT68_RS16650	COG3842	ATPase activity
IPT68_RS16670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPT68_RS16675	COG0215	cysteine-tRNA ligase activity
IPT68_RS16680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPT68_RS16685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPT68_RS16690	COG1329	Transcriptional regulator
IPT68_RS16705	COG5002	protein histidine kinase activity
IPT68_RS16780	COG3415	Transposase
IPT68_RS16780	COG2801	Transposase and inactivated derivatives
IPT68_RS16790	COG2188	Transcriptional regulator
IPT68_RS16850	COG0588	phosphoglycerate mutase activity
IPT68_RS16855	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS16860	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS16875	COG2207	Transcriptional regulator
IPT68_RS16875	COG1917	Cupin 2, conserved barrel domain protein
IPT68_RS16885	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS16995	COG2318	DinB family
IPT68_RS17000	COG1733	regulation of RNA biosynthetic process
IPT68_RS17045	COG0546	phosphoglycolate phosphatase activity
IPT68_RS17050	COG2188	Transcriptional regulator
IPT68_RS17060	COG2186	Transcriptional regulator
IPT68_RS17070	COG4552	Acetyltransferase involved in intracellular survival and related
IPT68_RS17080	COG1490	D-aminoacyl-tRNA deacylase activity
IPT68_RS17085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPT68_RS17095	COG3485	protocatechuate 3,4-dioxygenase
IPT68_RS17120	COG2897	thiosulfate sulfurtransferase activity
IPT68_RS17145	COG0745	RESPONSE REGULATOR receiver
IPT68_RS17150	COG1609	Transcriptional regulator
IPT68_RS17155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPT68_RS17165	COG0745	RESPONSE REGULATOR receiver
IPT68_RS17175	COG0737	Belongs to the 5'-nucleotidase family
IPT68_RS17180	COG0456	acetyltransferase
IPT68_RS17185	COG1725	Transcriptional regulator
IPT68_RS17190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPT68_RS17200	COG0406	alpha-ribazole phosphatase activity
IPT68_RS17200	COG0494	nUDIX hydrolase
IPT68_RS17215	COG1937	Protein conserved in bacteria
IPT68_RS17225	COG0306	phosphate transporter
IPT68_RS17230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPT68_RS17250	COG0277	FAD linked oxidase domain protein
IPT68_RS17255	COG0671	phosphoesterase, PA-phosphatase related
IPT68_RS17260	COG0741	lytic transglycosylase activity
IPT68_RS17260	COG1196	nuclear chromosome segregation
IPT68_RS17260	COG0739	heme binding
IPT68_RS17335	COG1846	Transcriptional regulator
IPT68_RS17350	COG1252	NADH dehydrogenase
IPT68_RS17375	COG0579	oxidoreductase
IPT68_RS17380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPT68_RS17405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPT68_RS17410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPT68_RS17415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPT68_RS17415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPT68_RS17425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPT68_RS17445	COG0513	Belongs to the DEAD box helicase family
IPT68_RS17480	COG1595	DNA-templated transcription, initiation
IPT68_RS17490	COG1643	Atp-dependent helicase
IPT68_RS17525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPT68_RS17545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPT68_RS17550	COG0047	phosphoribosylformylglycinamidine synthase activity
IPT68_RS17555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPT68_RS17590	COG2197	response regulator
IPT68_RS17600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPT68_RS17615	COG0151	Belongs to the GarS family
IPT68_RS17650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPT68_RS17680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPT68_RS17710	COG2375	cellular response to nickel ion
IPT68_RS17710	COG1132	(ABC) transporter
IPT68_RS17735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IPT68_RS17780	COG1191	sigma factor activity
IPT68_RS17785	COG1191	sigma factor activity
IPT68_RS17800	COG0477	Major facilitator Superfamily
IPT68_RS17805	COG2353	YceI-like domain
IPT68_RS17820	COG3467	pyridoxamine 5'-phosphate
IPT68_RS17830	COG0745	RESPONSE REGULATOR receiver
IPT68_RS17885	COG0784	Response regulator, receiver
IPT68_RS17895	COG0318	PFAM AMP-dependent synthetase and ligase
IPT68_RS17900	COG1595	DNA-templated transcription, initiation
IPT68_RS17960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPT68_RS17975	COG0653	protein targeting
IPT68_RS17995	COG0006	proline dipeptidase activity
IPT68_RS18015	COG1999	signal sequence binding
IPT68_RS18030	COG2837	iron assimilation
IPT68_RS18035	COG0077	Prephenate dehydratase
IPT68_RS18040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPT68_RS18045	COG0561	phosphatase activity
IPT68_RS18090	COG0789	Transcriptional regulator
IPT68_RS18095	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IPT68_RS18105	COG0561	phosphatase activity
IPT68_RS18110	COG0739	heme binding
IPT68_RS18120	COG4988	ABC transporter
IPT68_RS18125	COG1294	oxidase, subunit
IPT68_RS18130	COG1271	oxidase subunit
IPT68_RS18140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPT68_RS18145	COG1609	Transcriptional regulator
IPT68_RS18150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IPT68_RS18160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IPT68_RS18185	COG0662	Cupin 2, conserved barrel domain protein
IPT68_RS18190	COG1950	PFAM Membrane protein of
IPT68_RS18195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPT68_RS18200	COG0626	cystathionine gamma-synthase activity
IPT68_RS18235	COG2814	Major facilitator Superfamily
IPT68_RS18250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPT68_RS18255	COG0305	Participates in initiation and elongation during chromosome replication
IPT68_RS18265	COG0359	binds to the 23S rRNA
IPT68_RS18270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPT68_RS18275	COG0629	single-stranded DNA binding
IPT68_RS18280	COG0360	Binds together with S18 to 16S ribosomal RNA
IPT68_RS18305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPT68_RS18315	COG1260	myo-inositol-1-phosphate synthase
IPT68_RS18330	COG0617	tRNA 3'-terminal CCA addition
IPT68_RS18345	COG2815	serine threonine protein kinase
IPT68_RS18345	COG0515	serine threonine protein kinase
IPT68_RS18360	COG1595	DNA-templated transcription, initiation
IPT68_RS18370	COG0492	ferredoxin-NADP+ reductase activity
IPT68_RS18375	COG3118	belongs to the thioredoxin family
IPT68_RS18390	COG1192	Involved in chromosome partitioning
IPT68_RS18395	COG0357	Ribosomal RNA small subunit methyltransferase G
IPT68_RS18405	COG0706	membrane insertase activity
IPT68_RS18410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPT68_RS18415	COG0594	ribonuclease P activity
IPT68_RS18420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPT68_RS18425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPT68_RS18430	COG0592	DNA-directed DNA polymerase activity
IPT68_RS18435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPT68_RS18440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPT68_RS18445	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IPT68_RS18450	COG0187	DNA topoisomerase II activity
IPT68_RS18455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPT68_RS18505	COG0515	serine threonine protein kinase
IPT68_RS18530	COG0705	Rhomboid family
IPT68_RS18545	COG3764	Sortase (surface protein transpeptidase)
IPT68_RS18560	COG3764	Sortase (surface protein transpeptidase)
IPT68_RS18565	COG3764	Sortase (surface protein transpeptidase)
IPT68_RS18570	COG0515	serine threonine protein kinase
IPT68_RS18590	COG1716	ATPase activity
IPT68_RS18595	COG1716	ATPase activity
IPT68_RS18610	COG1136	(ABC) transporter
IPT68_RS18625	COG2197	response regulator
IPT68_RS18655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPT68_RS18660	COG2151	metal-sulfur cluster biosynthetic enzyme
IPT68_RS18665	COG3396	Phenylacetate-CoA oxygenase
IPT68_RS18670	COG3460	Phenylacetate-CoA oxygenase
IPT68_RS18675	COG3396	Phenylacetate-CoA oxygenase
IPT68_RS18700	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPT68_RS18705	COG1309	transcriptional regulator
IPT68_RS18710	COG1522	sequence-specific DNA binding
IPT68_RS18735	COG0303	'Molybdopterin
IPT68_RS18740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPT68_RS18760	COG0604	alcohol dehydrogenase
IPT68_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS18760	COG3321	synthase
IPT68_RS18775	COG0515	serine threonine protein kinase
IPT68_RS18780	COG0515	serine threonine protein kinase
IPT68_RS18800	COG0022	dehydrogenase e1 component
IPT68_RS18805	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS18860	COG1362	aminopeptidase activity
IPT68_RS18865	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS18880	COG1741	Belongs to the pirin family
IPT68_RS18895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPT68_RS19055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPT68_RS19070	COG1289	transmembrane transporter activity
IPT68_RS19075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPT68_RS19080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPT68_RS19120	COG1396	sequence-specific DNA binding
IPT68_RS19140	COG1957	nucleoside hydrolase
IPT68_RS19155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPT68_RS19160	COG0366	Alpha amylase catalytic
IPT68_RS19195	COG3903	Transcriptional regulator
IPT68_RS19195	COG3629	intracellular signal transduction
IPT68_RS19215	COG1278	Cold shock
IPT68_RS19230	COG1131	(ABC) transporter
IPT68_RS19250	COG1215	transferase activity, transferring glycosyl groups
IPT68_RS19285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IPT68_RS19290	COG0717	Belongs to the dCTP deaminase family
IPT68_RS19310	COG2409	Drug exporters of the RND superfamily
IPT68_RS19320	COG0515	serine threonine protein kinase
IPT68_RS19320	COG2815	serine threonine protein kinase
IPT68_RS19345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPT68_RS19350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPT68_RS19355	COG1120	ATPase activity
IPT68_RS19360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPT68_RS19390	COG1595	DNA-templated transcription, initiation
IPT68_RS19395	COG1801	Protein of unknown function DUF72
IPT68_RS19405	COG2181	nitrate reductase activity
IPT68_RS19405	COG0247	lactate metabolic process
IPT68_RS19410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPT68_RS19415	COG0443	Heat shock 70 kDa protein
IPT68_RS19420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPT68_RS19425	COG0484	heat shock protein binding
IPT68_RS19430	COG0789	Transcriptional regulator
IPT68_RS19435	COG4213	ABC transporter substrate-binding protein
IPT68_RS19460	COG0542	response to heat
IPT68_RS19510	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPT68_RS19525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPT68_RS19530	COG0191	fructose-bisphosphate aldolase activity
IPT68_RS19535	COG0477	Major facilitator Superfamily
IPT68_RS19550	COG3844	kynureninase activity
IPT68_RS19570	COG4585	Histidine kinase
IPT68_RS19575	COG2197	response regulator
IPT68_RS19590	COG3559	Exporter of polyketide antibiotics
IPT68_RS19595	COG1131	(ABC) transporter
IPT68_RS19610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPT68_RS19630	COG1802	Transcriptional regulator
IPT68_RS19635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPT68_RS19640	COG0693	protein deglycase activity
IPT68_RS19650	COG0515	serine threonine protein kinase
IPT68_RS19650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPT68_RS19665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPT68_RS19670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPT68_RS19700	COG1595	DNA-templated transcription, initiation
IPT68_RS19725	COG0701	Predicted permease
IPT68_RS19740	COG4249	Peptidase C14 caspase catalytic subunit p20
IPT68_RS19740	COG2319	Wd-40 repeat
IPT68_RS19795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPT68_RS19800	COG1115	amino acid carrier protein
IPT68_RS19800	COG1115	amino acid carrier protein
IPT68_RS19845	COG1408	metallophosphoesterase
IPT68_RS19855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPT68_RS19865	COG0003	Pfam Anion-transporting ATPase
IPT68_RS19890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPT68_RS19925	COG0596	Alpha beta hydrolase
IPT68_RS19935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPT68_RS19940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPT68_RS20010	COG1111	helicase
IPT68_RS20010	COG1205	dead DEAH box helicase
IPT68_RS20015	COG1366	Belongs to the anti-sigma-factor antagonist family
IPT68_RS20020	COG2172	sigma factor antagonist activity
IPT68_RS20025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPT68_RS20035	COG2890	protein-(glutamine-N5) methyltransferase activity
IPT68_RS20045	COG1754	DNA topoisomerase type I activity
IPT68_RS20045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPT68_RS20050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPT68_RS20055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPT68_RS20090	COG2814	Major facilitator Superfamily
IPT68_RS20100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IPT68_RS20130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPT68_RS20135	COG3629	intracellular signal transduction
IPT68_RS20135	COG3903	Transcriptional regulator
IPT68_RS20140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPT68_RS20140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPT68_RS20165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPT68_RS20175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPT68_RS20210	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS20240	COG0789	Transcriptional regulator
IPT68_RS20245	COG0586	Pfam SNARE associated Golgi protein
IPT68_RS20255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPT68_RS20260	COG2027	D-alanyl-D-alanine carboxypeptidase
IPT68_RS20270	COG0037	tRNA processing
IPT68_RS20285	COG0302	gtp cyclohydrolase
IPT68_RS20300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IPT68_RS20335	COG0649	NAD binding
IPT68_RS20350	COG2197	response regulator
IPT68_RS20355	COG1660	Displays ATPase and GTPase activities
IPT68_RS20375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPT68_RS20380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPT68_RS20390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IPT68_RS20410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IPT68_RS20440	COG0739	heme binding
IPT68_RS20460	COG0346	lactoylglutathione lyase activity
IPT68_RS20465	COG2205	protein histidine kinase activity
IPT68_RS20470	COG0745	RESPONSE REGULATOR receiver
IPT68_RS20480	COG1595	DNA-templated transcription, initiation
IPT68_RS20485	COG1194	a g-specific adenine glycosylase
IPT68_RS20495	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IPT68_RS20515	COG0248	Ppx GppA phosphatase
IPT68_RS20520	COG1082	Xylose isomerase domain protein TIM barrel
IPT68_RS20525	COG1309	transcriptional regulator
IPT68_RS20530	COG0129	dihydroxy-acid dehydratase activity
IPT68_RS20535	COG0515	serine threonine protein kinase
IPT68_RS20535	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPT68_RS20540	COG4991	sh3 domain protein
IPT68_RS20555	COG1129	ABC transporter
IPT68_RS20555	COG0842	Transport permease protein
IPT68_RS20565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPT68_RS20570	COG0180	Tryptophanyl-tRNA synthetase
IPT68_RS20590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPT68_RS20595	COG2223	nitrite transmembrane transporter activity
IPT68_RS20600	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPT68_RS20650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IPT68_RS20655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPT68_RS20660	COG0181	hydroxymethylbilane synthase activity
IPT68_RS20665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPT68_RS20665	COG1648	precorrin-2 dehydrogenase activity
IPT68_RS20670	COG0113	porphobilinogen synthase activity
IPT68_RS20675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPT68_RS20710	COG0018	arginyl-trna synthetase
IPT68_RS20715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IPT68_RS20735	COG1690	Belongs to the RtcB family
IPT68_RS20745	COG1742	UPF0060 membrane protein
IPT68_RS20750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS20760	COG0745	RESPONSE REGULATOR receiver
IPT68_RS20805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPT68_RS20810	COG0406	alpha-ribazole phosphatase activity
IPT68_RS20820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPT68_RS20825	COG0785	Cytochrome C biogenesis protein
IPT68_RS20830	COG1333	cytochrome c biogenesis protein
IPT68_RS20835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPT68_RS20850	COG3832	glyoxalase III activity
IPT68_RS20870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IPT68_RS20875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPT68_RS20885	COG0163	prenyltransferase activity
IPT68_RS20895	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPT68_RS20900	COG1573	uracil-dna glycosylase
IPT68_RS20915	COG1309	transcriptional regulator
IPT68_RS20935	COG1595	DNA-templated transcription, initiation
IPT68_RS20940	COG1278	Cold shock
IPT68_RS20945	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPT68_RS20960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPT68_RS20975	COG2226	methyltransferase
IPT68_RS21000	COG3103	Sh3 type 3 domain protein
IPT68_RS21000	COG0791	NLP P60 protein
IPT68_RS21000	COG1388	LysM domain
IPT68_RS21010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21020	COG0649	NAD binding
IPT68_RS21030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IPT68_RS21035	COG1034	ATP synthesis coupled electron transport
IPT68_RS21040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPT68_RS21045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21050	COG0839	Belongs to the complex I subunit 6 family
IPT68_RS21055	COG0713	ATP synthesis coupled electron transport
IPT68_RS21060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPT68_RS21070	COG1007	ATP synthesis coupled electron transport
IPT68_RS21075	COG0514	ATP-dependent DNA helicase (RecQ)
IPT68_RS21095	COG0561	phosphatase activity
IPT68_RS21125	COG0142	geranyltranstransferase activity
IPT68_RS21145	COG0655	NAD(P)H dehydrogenase (quinone) activity
IPT68_RS21170	COG1733	regulation of RNA biosynthetic process
IPT68_RS21185	COG0702	epimerase
IPT68_RS21190	COG1733	regulation of RNA biosynthetic process
IPT68_RS21195	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPT68_RS21215	COG4585	Histidine kinase
IPT68_RS21220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPT68_RS21240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPT68_RS21245	COG0839	Belongs to the complex I subunit 6 family
IPT68_RS21250	COG0713	ATP synthesis coupled electron transport
IPT68_RS21255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPT68_RS21265	COG1007	ATP synthesis coupled electron transport
IPT68_RS21270	COG0501	Belongs to the peptidase M48B family
IPT68_RS21275	COG3304	Inner membrane component domain
IPT68_RS21285	COG2261	transglycosylase associated protein
IPT68_RS21290	COG1666	GTP binding
IPT68_RS21310	COG0702	epimerase
IPT68_RS21330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPT68_RS21335	COG2030	dehydratase
IPT68_RS21345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPT68_RS21350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPT68_RS21355	COG0436	Aminotransferase
IPT68_RS21370	COG0250	Participates in transcription elongation, termination and antitermination
IPT68_RS21375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPT68_RS21380	COG0081	regulation of translation
IPT68_RS21400	COG0222	ribosome binding
IPT68_RS21405	COG0085	RNA polymerase activity
IPT68_RS21410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPT68_RS21425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPT68_RS21430	COG0049	tRNA binding
IPT68_RS21435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPT68_RS21445	COG2755	lipolytic protein G-D-S-L family
IPT68_RS21445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPT68_RS21450	COG1131	(ABC) transporter
IPT68_RS21470	COG0051	transcription antitermination factor activity, RNA binding
IPT68_RS21475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPT68_RS21480	COG0088	Forms part of the polypeptide exit tunnel
IPT68_RS21485	COG0089	rRNA binding
IPT68_RS21490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPT68_RS21495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPT68_RS21500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPT68_RS21505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPT68_RS21510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPT68_RS21515	COG0255	Belongs to the universal ribosomal protein uL29 family
IPT68_RS21520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPT68_RS21525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPT68_RS21530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPT68_RS21535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPT68_RS21540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPT68_RS21545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPT68_RS21550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPT68_RS21555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPT68_RS21560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPT68_RS21565	COG1841	ribosomal large subunit assembly
IPT68_RS21570	COG0200	Binds to the 23S rRNA
IPT68_RS21580	COG0563	adenylate kinase activity
IPT68_RS21590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPT68_RS21595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPT68_RS21600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPT68_RS21605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPT68_RS21610	COG0202	RNA polymerase activity
IPT68_RS21615	COG0203	ribosomal protein L17
IPT68_RS21620	COG0101	tRNA pseudouridine synthase activity
IPT68_RS21635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPT68_RS21640	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPT68_RS21645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPT68_RS21655	COG1072	(Pantothenic acid kinase))
IPT68_RS21660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPT68_RS21675	COG0736	holo-[acyl-carrier-protein] synthase activity
IPT68_RS21680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPT68_RS21680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPT68_RS21685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPT68_RS21695	COG0802	atpase or kinase
IPT68_RS21720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPT68_RS21730	COG1472	Belongs to the glycosyl hydrolase 3 family
IPT68_RS21740	COG1175	transmembrane transport
IPT68_RS21745	COG1653	transport
IPT68_RS21750	COG1609	Transcriptional regulator
IPT68_RS21785	COG0726	polysaccharide deacetylase
IPT68_RS21790	COG0726	polysaccharide deacetylase
IPT68_RS21795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPT68_RS21800	COG0459	protein refolding
IPT68_RS21810	COG4221	oxidoreductase activity
IPT68_RS21820	COG0583	DNA-binding transcription factor activity
IPT68_RS21835	COG1595	DNA-templated transcription, initiation
IPT68_RS21845	COG0516	GMP reductase activity
IPT68_RS21860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPT68_RS21875	COG0515	serine threonine protein kinase
IPT68_RS21880	COG0515	serine threonine protein kinase
IPT68_RS21885	COG0515	serine threonine protein kinase
IPT68_RS21890	COG0515	serine threonine protein kinase
IPT68_RS21890	COG2815	serine threonine protein kinase
IPT68_RS21895	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS21915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPT68_RS21915	COG0519	Catalyzes the synthesis of GMP from XMP
IPT68_RS21960	COG2197	response regulator
IPT68_RS21995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS21995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS22010	COG0714	Associated with various cellular activities
IPT68_RS22015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IPT68_RS22020	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IPT68_RS22035	COG0045	succinate-CoA ligase (ADP-forming) activity
IPT68_RS22065	COG0138	bifunctional purine biosynthesis protein purh
IPT68_RS22075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPT68_RS22090	COG0039	L-malate dehydrogenase activity
IPT68_RS22100	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS22110	COG0517	IMP dehydrogenase activity
IPT68_RS22110	COG4175	Glycine betaine
IPT68_RS22115	COG4176	ABC-type proline glycine betaine transport system permease component
IPT68_RS22125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IPT68_RS22135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS22140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPT68_RS22145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPT68_RS22150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPT68_RS22170	COG0180	Tryptophanyl-tRNA synthetase
IPT68_RS22200	COG1295	ribonuclease BN
IPT68_RS22205	COG1686	Belongs to the peptidase S11 family
IPT68_RS22215	COG1408	metallophosphoesterase
IPT68_RS22225	COG2205	protein histidine kinase activity
IPT68_RS22230	COG0745	RESPONSE REGULATOR receiver
IPT68_RS22235	COG2409	Drug exporters of the RND superfamily
IPT68_RS22275	COG1053	succinate dehydrogenase
IPT68_RS22285	COG2009	succinate dehydrogenase
IPT68_RS22405	COG1595	DNA-templated transcription, initiation
IPT68_RS22420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS22420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS22435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPT68_RS22465	COG1216	Glycosyl transferase, family 2
IPT68_RS22480	COG2089	acid synthase
IPT68_RS22490	COG2226	methyltransferase
IPT68_RS22495	COG1473	amidohydrolase
IPT68_RS22495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPT68_RS22500	COG1744	ABC transporter substrate-binding protein PnrA-like
IPT68_RS22505	COG1744	ABC transporter substrate-binding protein PnrA-like
IPT68_RS22510	COG3845	ABC transporter
IPT68_RS22520	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPT68_RS22545	COG3344	reverse transcriptase
IPT68_RS22570	COG2814	Major facilitator Superfamily
IPT68_RS22575	COG0583	DNA-binding transcription factor activity
IPT68_RS22585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPT68_RS22610	COG2205	protein histidine kinase activity
IPT68_RS22615	COG0745	RESPONSE REGULATOR receiver
IPT68_RS22620	COG1595	DNA-templated transcription, initiation
IPT68_RS22665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPT68_RS22670	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS22675	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS22685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPT68_RS22715	COG4770	biotin carboxylase activity
IPT68_RS22725	COG0424	maF-like protein
IPT68_RS22745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPT68_RS22755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPT68_RS22765	COG1024	Enoyl-CoA hydratase
IPT68_RS22775	COG2986	histidine ammonia-lyase
IPT68_RS22805	COG1136	(ABC) transporter
IPT68_RS22810	COG1404	Belongs to the peptidase S8 family
IPT68_RS22820	COG1064	alcohol dehydrogenase
IPT68_RS22875	COG1595	DNA-templated transcription, initiation
IPT68_RS22880	COG2255	four-way junction helicase activity
IPT68_RS22885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPT68_RS22900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPT68_RS22910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPT68_RS22925	COG1331	Highly conserved protein containing a thioredoxin domain
IPT68_RS22960	COG1309	transcriptional regulator
IPT68_RS22970	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPT68_RS23000	COG0436	Aminotransferase
IPT68_RS23010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPT68_RS23025	COG1414	Transcriptional regulator
IPT68_RS23030	COG0251	oxidation-reduction process
IPT68_RS23075	COG1595	DNA-templated transcription, initiation
IPT68_RS23100	COG2894	cell division
IPT68_RS23135	COG2197	response regulator
IPT68_RS23190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPT68_RS23195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IPT68_RS23215	COG1136	(ABC) transporter
IPT68_RS23235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPT68_RS23250	COG0114	fumarate hydratase activity
IPT68_RS23255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IPT68_RS23255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IPT68_RS23280	COG0778	Nitroreductase
IPT68_RS23285	COG1722	exodeoxyribonuclease VII activity
IPT68_RS23290	COG1570	exodeoxyribonuclease VII activity
IPT68_RS23300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPT68_RS23315	COG0012	GTP binding
IPT68_RS23505	COG1053	succinate dehydrogenase
IPT68_RS23525	COG1217	gtp-binding protein TYPA
IPT68_RS23530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPT68_RS23535	COG0747	negative chemotaxis
IPT68_RS23540	COG0601	transmembrane transport
IPT68_RS23545	COG0444	Belongs to the ABC transporter superfamily
IPT68_RS23550	COG4608	Belongs to the ABC transporter superfamily
IPT68_RS23560	COG0601	transmembrane transport
IPT68_RS23565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPT68_RS23570	COG0444	Belongs to the ABC transporter superfamily
IPT68_RS23575	COG4608	Belongs to the ABC transporter superfamily
IPT68_RS23590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPT68_RS23635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPT68_RS23640	COG1611	Belongs to the LOG family
IPT68_RS23645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPT68_RS23655	COG2818	Glycosylase
IPT68_RS23660	COG1024	Enoyl-CoA hydratase
IPT68_RS23675	COG1595	DNA-templated transcription, initiation
IPT68_RS23685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPT68_RS23690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPT68_RS23725	COG0598	Magnesium transport protein CorA
IPT68_RS23750	COG2095	MarC family integral membrane protein
IPT68_RS23760	COG1432	Conserved Protein
IPT68_RS23770	COG0513	Belongs to the DEAD box helicase family
IPT68_RS23835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IPT68_RS23845	COG1733	regulation of RNA biosynthetic process
IPT68_RS23870	COG0210	DNA helicase
IPT68_RS23875	COG0210	DNA helicase
IPT68_RS23920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPT68_RS23975	COG3480	Lon protease (S16) C-terminal proteolytic domain
IPT68_RS23985	COG1615	UPF0182 protein
IPT68_RS24010	COG0753	catalase activity
IPT68_RS24020	COG0483	inositol monophosphate 1-phosphatase activity
IPT68_RS24035	COG1162	GTPase activity
IPT68_RS24040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPT68_RS24050	COG2135	peptidase activity
IPT68_RS24060	COG1595	DNA-templated transcription, initiation
IPT68_RS24065	COG5662	AntiSigma factor
IPT68_RS24070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPT68_RS24070	COG2199	diguanylate cyclase activity
IPT68_RS24085	COG0242	peptide deformylase activity
IPT68_RS24095	COG2124	cytochrome p450
IPT68_RS24135	COG1966	Carbon starvation protein
IPT68_RS24140	COG2188	Transcriptional regulator
IPT68_RS24145	COG2182	Extracellular solute-binding protein
IPT68_RS24150	COG1175	transmembrane transport
IPT68_RS24155	COG0395	ABC-type sugar transport system, permease component
IPT68_RS24160	COG1472	Belongs to the glycosyl hydrolase 3 family
IPT68_RS24170	COG0363	glucosamine-6-phosphate deaminase activity
IPT68_RS24175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPT68_RS24195	COG1597	lipid kinase activity
IPT68_RS24225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IPT68_RS24235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPT68_RS24240	COG0142	geranyltranstransferase activity
IPT68_RS24280	COG4106	trans-aconitate 2-methyltransferase activity
IPT68_RS24285	COG1126	abc transporter atp-binding protein
IPT68_RS24295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPT68_RS24300	COG0281	malic enzyme
IPT68_RS24305	COG0604	alcohol dehydrogenase
IPT68_RS24350	COG2255	four-way junction helicase activity
IPT68_RS24370	COG0567	Dehydrogenase, E1 component
IPT68_RS24370	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS24375	COG2205	protein histidine kinase activity
IPT68_RS24380	COG0745	RESPONSE REGULATOR receiver
IPT68_RS24395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPT68_RS24410	COG5002	protein histidine kinase activity
IPT68_RS24440	COG0791	NLP P60 protein
IPT68_RS24470	COG0768	penicillin binding
IPT68_RS24485	COG2205	protein histidine kinase activity
IPT68_RS24505	COG1793	dna ligase
IPT68_RS24505	COG3285	dna ligase
IPT68_RS24510	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IPT68_RS24515	COG1122	ATPase activity
IPT68_RS24520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IPT68_RS24525	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IPT68_RS24575	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS24620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IPT68_RS24755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPT68_RS25050	COG2223	nitrite transmembrane transporter activity
IPT68_RS25185	COG1051	belongs to the nudix hydrolase family
IPT68_RS25205	COG0529	Catalyzes the synthesis of activated sulfate
IPT68_RS25220	COG0302	gtp cyclohydrolase
IPT68_RS25225	COG0602	queuosine metabolic process
IPT68_RS25375	COG0018	arginyl-trna synthetase
IPT68_RS25380	COG0019	diaminopimelate decarboxylase activity
IPT68_RS25385	COG0460	homoserine dehydrogenase
IPT68_RS25390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPT68_RS25395	COG0083	homoserine kinase activity
IPT68_RS25415	COG0254	rRNA binding
IPT68_RS25420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPT68_RS25425	COG2890	protein-(glutamine-N5) methyltransferase activity
IPT68_RS25435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPT68_RS25440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPT68_RS25460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPT68_RS25465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPT68_RS25470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPT68_RS25475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPT68_RS25480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPT68_RS25485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPT68_RS25490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPT68_RS25505	COG2197	response regulator
IPT68_RS25510	COG4585	Histidine kinase
IPT68_RS25525	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPT68_RS25540	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IPT68_RS25575	COG1131	(ABC) transporter
IPT68_RS25595	COG0183	Belongs to the thiolase family
IPT68_RS25615	COG2205	protein histidine kinase activity
IPT68_RS25670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS25670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS25725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IPT68_RS25730	COG0857	belongs to the CobB CobQ family
IPT68_RS25730	COG0280	phosphate acetyltransferase
IPT68_RS25735	COG0205	6-phosphofructokinase activity
IPT68_RS25745	COG0395	ABC-type sugar transport system, permease component
IPT68_RS25750	COG1175	transmembrane transport
IPT68_RS25760	COG4565	transcriptional regulatory protein
IPT68_RS25765	COG3290	protein histidine kinase activity
IPT68_RS25770	COG1301	dicarboxylic acid transport
IPT68_RS25790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPT68_RS25795	COG3281	Trehalose synthase
IPT68_RS25805	COG0366	Alpha amylase catalytic
IPT68_RS25815	COG0058	SHG alpha-glucan phosphorylase activity
IPT68_RS25830	COG1132	(ABC) transporter
IPT68_RS25835	COG1132	(ABC) transporter
IPT68_RS25840	COG1132	(ABC) transporter
IPT68_RS25845	COG1132	(ABC) transporter
IPT68_RS25860	COG1376	ErfK ybiS ycfS ynhG family protein
IPT68_RS25880	COG0789	Transcriptional regulator
IPT68_RS25890	COG3291	Pkd domain containing protein
IPT68_RS25890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IPT68_RS25940	COG1760	l-serine dehydratase
IPT68_RS25945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPT68_RS25950	COG0509	glycine decarboxylation via glycine cleavage system
IPT68_RS25955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPT68_RS25975	COG0747	negative chemotaxis
IPT68_RS25980	COG0601	transmembrane transport
IPT68_RS25985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPT68_RS25990	COG0444	Belongs to the ABC transporter superfamily
IPT68_RS25995	COG4608	Belongs to the ABC transporter superfamily
IPT68_RS26000	COG2860	membrane
IPT68_RS26010	COG1309	transcriptional regulator
IPT68_RS26030	COG3023	N-Acetylmuramoyl-L-alanine amidase
IPT68_RS26035	COG0482	sulfurtransferase activity
IPT68_RS26045	COG1611	Belongs to the LOG family
IPT68_RS26050	COG4221	oxidoreductase activity
IPT68_RS26060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPT68_RS26070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPT68_RS26075	COG0154	amidase activity
IPT68_RS26085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPT68_RS26095	COG2409	Drug exporters of the RND superfamily
IPT68_RS26100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPT68_RS26115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPT68_RS26115	COG1672	PFAM Archaeal ATPase
IPT68_RS26125	COG2133	pyrroloquinoline quinone binding
IPT68_RS26130	COG0667	Aldo Keto reductase
IPT68_RS26140	COG5001	Diguanylate cyclase
IPT68_RS26150	COG0440	acetolactate synthase activity
IPT68_RS26155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPT68_RS26160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPT68_RS26170	COG2508	Transcriptional regulator
IPT68_RS26175	COG0506	proline dehydrogenase activity
IPT68_RS26180	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS26195	COG0473	3-isopropylmalate dehydrogenase activity
IPT68_RS26200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPT68_RS26210	COG0831	urea catabolic process
IPT68_RS26210	COG0832	Belongs to the urease beta subunit family
IPT68_RS26215	COG0804	urea catabolic process
IPT68_RS26220	COG2957	Belongs to the agmatine deiminase family
IPT68_RS26235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPT68_RS26285	COG2353	YceI-like domain
IPT68_RS26290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPT68_RS26310	COG2018	Roadblock/LC7 domain
IPT68_RS26330	COG2018	Roadblock/LC7 domain
IPT68_RS26345	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPT68_RS26350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPT68_RS26395	COG1414	Transcriptional regulator
IPT68_RS26400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IPT68_RS26405	COG0066	3-isopropylmalate dehydratase activity
IPT68_RS26415	COG0776	regulation of translation
IPT68_RS26425	COG1920	GTP binding
IPT68_RS26435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPT68_RS26440	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPT68_RS26460	COG0351	phosphomethylpyrimidine kinase
IPT68_RS26465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPT68_RS26470	COG1461	Dihydroxyacetone kinase
IPT68_RS26480	COG0326	Molecular chaperone. Has ATPase activity
IPT68_RS26490	COG0742	ribosomal rna small subunit methyltransferase
IPT68_RS26495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPT68_RS26510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPT68_RS26515	COG0571	ribonuclease III activity
IPT68_RS26520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPT68_RS26525	COG1733	regulation of RNA biosynthetic process
IPT68_RS26565	COG2340	Cysteine-rich secretory protein family
IPT68_RS26570	COG1254	Belongs to the acylphosphatase family
IPT68_RS26580	COG1196	nuclear chromosome segregation
IPT68_RS26585	COG0477	Major facilitator Superfamily
IPT68_RS26620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IPT68_RS26630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPT68_RS26645	COG0228	four-way junction DNA binding
IPT68_RS26650	COG1837	Belongs to the UPF0109 family
IPT68_RS26655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPT68_RS26660	COG0336	Belongs to the RNA methyltransferase TrmD family
IPT68_RS26665	COG0335	large ribosomal subunit rRNA binding
IPT68_RS26680	COG0681	Belongs to the peptidase S26 family
IPT68_RS26685	COG0681	Belongs to the peptidase S26 family
IPT68_RS26700	COG0792	nuclease activity
IPT68_RS26715	COG1191	sigma factor activity
IPT68_RS26725	COG4942	peptidase
IPT68_RS26730	COG0052	Belongs to the universal ribosomal protein uS2 family
IPT68_RS26735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPT68_RS26740	COG0528	UMP kinase activity
IPT68_RS26745	COG0233	cytoplasmic translational termination
IPT68_RS26750	COG0575	Belongs to the CDS family
IPT68_RS26760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPT68_RS26770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IPT68_RS26775	COG3842	ATPase activity
IPT68_RS26805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPT68_RS26815	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS26825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPT68_RS26830	COG0254	rRNA binding
IPT68_RS26835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPT68_RS26840	COG0584	glycerophosphoryl diester phosphodiesterase
IPT68_RS26845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPT68_RS26870	COG3842	ATPase activity
IPT68_RS26880	COG1177	transmembrane transport
IPT68_RS26885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPT68_RS26905	COG1404	Belongs to the peptidase S8 family
IPT68_RS26925	COG2508	Transcriptional regulator
IPT68_RS26930	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS27025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPT68_RS27030	COG0750	zinc metalloprotease
IPT68_RS27035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPT68_RS27050	COG0442	prolyl-tRNA aminoacylation
IPT68_RS27070	COG0779	Required for maturation of 30S ribosomal subunits
IPT68_RS27095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPT68_RS27100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPT68_RS27115	COG0455	bacterial-type flagellum organization
IPT68_RS27135	COG1404	Belongs to the peptidase S8 family
IPT68_RS27150	COG1404	Belongs to the peptidase S8 family
IPT68_RS27185	COG1674	ftsk spoiiie
IPT68_RS27200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPT68_RS27205	COG1185	polyribonucleotide nucleotidyltransferase activity
IPT68_RS27210	COG0612	Peptidase, M16
IPT68_RS27215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPT68_RS27235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IPT68_RS27240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPT68_RS27245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPT68_RS27275	COG2208	phosphoserine phosphatase activity
IPT68_RS27275	COG2770	Histidine kinase
IPT68_RS27280	COG3437	response regulator, receiver
IPT68_RS27280	COG3850	Histidine kinase
IPT68_RS27280	COG4999	Histidine kinase
IPT68_RS27280	COG2205	protein histidine kinase activity
IPT68_RS27290	COG1674	ftsk spoiiie
IPT68_RS27300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPT68_RS27310	COG1546	Belongs to the CinA family
IPT68_RS27310	COG1058	Belongs to the CinA family
IPT68_RS27315	COG1396	sequence-specific DNA binding
IPT68_RS27320	COG0783	Belongs to the Dps family
IPT68_RS27330	COG1201	RNA secondary structure unwinding
IPT68_RS27360	COG0628	permease
IPT68_RS27370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPT68_RS27380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPT68_RS27395	COG0765	amino acid transport
IPT68_RS27400	COG0765	amino acid transport
IPT68_RS27405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPT68_RS27410	COG1126	abc transporter atp-binding protein
IPT68_RS27415	COG0745	RESPONSE REGULATOR receiver
IPT68_RS27420	COG2205	protein histidine kinase activity
IPT68_RS27445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPT68_RS27465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPT68_RS27475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPT68_RS27480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPT68_RS27490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPT68_RS27525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPT68_RS27530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPT68_RS27535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPT68_RS27550	COG0588	phosphoglycerate mutase activity
IPT68_RS27560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPT68_RS27600	COG1802	Transcriptional regulator
IPT68_RS27605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPT68_RS27620	COG0187	DNA topoisomerase II activity
IPT68_RS27630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPT68_RS27635	COG4565	transcriptional regulatory protein
IPT68_RS27640	COG3290	protein histidine kinase activity
IPT68_RS27655	COG0372	Belongs to the citrate synthase family
IPT68_RS27670	COG0523	cobalamin synthesis protein
IPT68_RS27675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPT68_RS27695	COG1802	Transcriptional regulator
IPT68_RS27700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPT68_RS27720	COG1435	thymidine kinase activity
IPT68_RS27755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPT68_RS27770	COG0745	RESPONSE REGULATOR receiver
IPT68_RS27775	COG2205	protein histidine kinase activity
IPT68_RS27800	COG0756	dUTP diphosphatase activity
IPT68_RS27835	COG0569	domain protein
IPT68_RS27840	COG0531	amino acid
IPT68_RS27845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPT68_RS27860	COG0667	Aldo Keto reductase
IPT68_RS27865	COG0702	epimerase
IPT68_RS27870	COG1073	alpha beta
IPT68_RS27875	COG1073	alpha beta
IPT68_RS27920	COG2124	cytochrome p450
IPT68_RS27930	COG0596	Alpha beta hydrolase
IPT68_RS27960	COG1309	transcriptional regulator
IPT68_RS27990	COG1366	Belongs to the anti-sigma-factor antagonist family
IPT68_RS27995	COG1366	Belongs to the anti-sigma-factor antagonist family
IPT68_RS28025	COG1799	cell septum assembly
IPT68_RS28060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IPT68_RS28065	COG2235	arginine
IPT68_RS28070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPT68_RS28080	COG1024	Enoyl-CoA hydratase
IPT68_RS28120	COG1191	sigma factor activity
IPT68_RS28130	COG0783	Belongs to the Dps family
IPT68_RS28170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPT68_RS28180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPT68_RS28190	COG1653	transport
IPT68_RS28195	COG1175	transmembrane transport
IPT68_RS28200	COG0395	ABC-type sugar transport system, permease component
IPT68_RS28205	COG1940	carbohydrate kinase activity
IPT68_RS28210	COG4213	ABC transporter substrate-binding protein
IPT68_RS28220	COG4214	carbohydrate transport
IPT68_RS28225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPT68_RS28230	COG0531	amino acid
IPT68_RS28255	COG1316	TRANSCRIPTIONal
IPT68_RS28260	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS28265	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS28270	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS28275	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS28285	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPT68_RS28285	COG1024	Enoyl-CoA hydratase
IPT68_RS28290	COG0183	Belongs to the thiolase family
IPT68_RS28295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPT68_RS28310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPT68_RS28325	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPT68_RS28335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IPT68_RS28340	COG3253	May function as heme-dependent peroxidase
IPT68_RS28355	COG3220	belongs to the UPF0276 family
IPT68_RS28410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPT68_RS28415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPT68_RS28440	COG3938	Belongs to the proline racemase family
IPT68_RS28445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPT68_RS28460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPT68_RS28465	COG1968	undecaprenyl-diphosphatase activity
IPT68_RS28475	COG0745	RESPONSE REGULATOR receiver
IPT68_RS28490	COG1174	glycine betaine transport
IPT68_RS28510	COG2018	Roadblock/LC7 domain
IPT68_RS28540	COG1309	transcriptional regulator
IPT68_RS28550	COG2124	cytochrome p450
IPT68_RS28635	COG0583	DNA-binding transcription factor activity
IPT68_RS28650	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS28685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IPT68_RS28690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IPT68_RS28690	COG1116	anion transmembrane transporter activity
IPT68_RS28710	COG0529	Catalyzes the synthesis of activated sulfate
IPT68_RS28715	COG0175	sulfate reduction
IPT68_RS28745	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS28765	COG4977	sequence-specific DNA binding
IPT68_RS28765	COG1917	Cupin 2, conserved barrel domain protein
IPT68_RS28795	COG2040	homocysteine
IPT68_RS28835	COG0277	FAD linked oxidase domain protein
IPT68_RS28845	COG5520	Belongs to the glycosyl hydrolase 30 family
IPT68_RS28845	COG4447	cellulose binding
IPT68_RS28845	COG3291	Pkd domain containing protein
IPT68_RS28850	COG1162	GTPase activity
IPT68_RS28860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPT68_RS28915	COG3385	transposase activity
IPT68_RS28925	COG3335	DDE superfamily endonuclease
IPT68_RS28940	COG0515	serine threonine protein kinase
IPT68_RS29005	COG2197	response regulator
IPT68_RS29015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IPT68_RS29050	COG0673	inositol 2-dehydrogenase activity
IPT68_RS29060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPT68_RS29070	COG2264	protein methyltransferase activity
IPT68_RS29115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IPT68_RS29160	COG1802	Transcriptional regulator
IPT68_RS29170	COG3835	regulator
IPT68_RS29185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPT68_RS29235	COG1819	glycosyl
IPT68_RS29285	COG4585	Histidine kinase
IPT68_RS29290	COG2197	response regulator
IPT68_RS29295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPT68_RS29295	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPT68_RS29300	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPT68_RS29315	COG3629	intracellular signal transduction
IPT68_RS29315	COG3903	Transcriptional regulator
IPT68_RS29320	COG0736	holo-[acyl-carrier-protein] synthase activity
IPT68_RS29325	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPT68_RS29335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPT68_RS29340	COG3321	synthase
IPT68_RS29340	COG0604	alcohol dehydrogenase
IPT68_RS29390	COG3629	intracellular signal transduction
IPT68_RS29415	COG0531	amino acid
IPT68_RS29425	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPT68_RS29430	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IPT68_RS29435	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IPT68_RS29490	COG0789	Transcriptional regulator
IPT68_RS29495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPT68_RS29545	COG5297	Belongs to the glycosyl hydrolase family 6
IPT68_RS29560	COG3960	tartronate-semialdehyde synthase activity
IPT68_RS29575	COG2084	Dehydrogenase
IPT68_RS29580	COG3622	Belongs to the hyi family
IPT68_RS29600	COG2351	hydroxyisourate hydrolase activity
IPT68_RS29625	COG1733	regulation of RNA biosynthetic process
IPT68_RS29640	COG0406	alpha-ribazole phosphatase activity
IPT68_RS29645	COG0436	Aminotransferase
IPT68_RS29650	COG1733	regulation of RNA biosynthetic process
IPT68_RS29665	COG4264	IucA IucC family
IPT68_RS29680	COG1309	transcriptional regulator
IPT68_RS29690	COG1846	Transcriptional regulator
IPT68_RS29705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IPT68_RS29755	COG0477	Major facilitator Superfamily
IPT68_RS29780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IPT68_RS29795	COG1414	Transcriptional regulator
IPT68_RS29800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPT68_RS29805	COG4266	Belongs to the allantoicase family
IPT68_RS29810	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS29840	COG2197	response regulator
IPT68_RS29850	COG0673	inositol 2-dehydrogenase activity
IPT68_RS29855	COG2188	Transcriptional regulator
IPT68_RS29875	COG1940	carbohydrate kinase activity
IPT68_RS29885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPT68_RS29905	COG0589	response to stress
IPT68_RS29920	COG0549	Belongs to the carbamate kinase family
IPT68_RS29960	COG0778	Nitroreductase
IPT68_RS29965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPT68_RS29970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPT68_RS30000	COG2124	cytochrome p450
IPT68_RS30000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IPT68_RS30025	COG0582	viral genome integration into host DNA
IPT68_RS30040	COG2186	Transcriptional regulator
IPT68_RS30055	COG0582	viral genome integration into host DNA
IPT68_RS30065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS30070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IPT68_RS30095	COG0405	Gamma-glutamyltransferase
IPT68_RS30100	COG0542	response to heat
IPT68_RS30125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPT68_RS30140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPT68_RS30150	COG1953	Uracil, thiamine, allantoin
IPT68_RS30175	COG0483	inositol monophosphate 1-phosphatase activity
IPT68_RS30185	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IPT68_RS30210	COG0640	Transcriptional regulator
IPT68_RS30290	COG1929	Belongs to the glycerate kinase type-1 family
IPT68_RS30295	COG0667	Aldo Keto reductase
IPT68_RS30305	COG0688	phosphatidylethanolamine metabolic process
IPT68_RS30310	COG1960	acyl-CoA dehydrogenase activity
IPT68_RS30320	COG2301	Belongs to the HpcH HpaI aldolase family
IPT68_RS30325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS30325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPT68_RS30330	COG0604	alcohol dehydrogenase
IPT68_RS30340	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPT68_RS30360	COG0596	Alpha beta hydrolase
IPT68_RS30410	COG2172	sigma factor antagonist activity
IPT68_RS30410	COG2208	phosphoserine phosphatase activity
IPT68_RS30410	COG1366	Belongs to the anti-sigma-factor antagonist family
IPT68_RS30415	COG2226	methyltransferase
IPT68_RS30420	COG2362	D-Aminopeptidase
IPT68_RS30425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPT68_RS30430	COG1506	peptidase
IPT68_RS30430	COG0823	Involved in the tonB-independent uptake of proteins
IPT68_RS30430	COG4946	Tricorn protease homolog
IPT68_RS30435	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPT68_RS30455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS30525	COG2226	methyltransferase
IPT68_RS30530	COG1597	lipid kinase activity
IPT68_RS30555	COG0693	protein deglycase activity
IPT68_RS30570	COG0028	Belongs to the TPP enzyme family
IPT68_RS30630	COG0443	Heat shock 70 kDa protein
IPT68_RS30635	COG2205	protein histidine kinase activity
IPT68_RS30635	COG0784	Response regulator, receiver
IPT68_RS30635	COG5002	protein histidine kinase activity
IPT68_RS30665	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPT68_RS30670	COG2226	methyltransferase
IPT68_RS30680	COG2378	regulation of single-species biofilm formation
IPT68_RS30685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IPT68_RS30695	COG0656	L-ascorbic acid biosynthetic process
IPT68_RS30705	COG0583	DNA-binding transcription factor activity
IPT68_RS30730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPT68_RS30745	COG3383	formate dehydrogenase (NAD+) activity
IPT68_RS30750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IPT68_RS30760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPT68_RS30770	COG1940	carbohydrate kinase activity
IPT68_RS30775	COG1129	ABC transporter
IPT68_RS30780	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPT68_RS30790	COG0673	inositol 2-dehydrogenase activity
IPT68_RS30825	COG0084	hydrolase, TatD family'
IPT68_RS30845	COG2223	nitrite transmembrane transporter activity
IPT68_RS30855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPT68_RS30865	COG0045	succinate-CoA ligase (ADP-forming) activity
IPT68_RS30875	COG1012	belongs to the aldehyde dehydrogenase family
IPT68_RS30900	COG0210	DNA helicase
IPT68_RS30905	COG0515	serine threonine protein kinase
IPT68_RS30985	COG0443	Heat shock 70 kDa protein
IPT68_RS30990	COG0655	NAD(P)H dehydrogenase (quinone) activity
IPT68_RS31005	COG0584	glycerophosphoryl diester phosphodiesterase
IPT68_RS31015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPT68_RS31025	COG2182	Extracellular solute-binding protein
IPT68_RS31030	COG1175	transmembrane transport
IPT68_RS31035	COG0395	ABC-type sugar transport system, permease component
IPT68_RS31040	COG2723	6-phospho-beta-galactosidase activity
IPT68_RS31065	COG1183	phosphatidylcholine synthase activity
IPT68_RS31080	COG0438	transferase activity, transferring glycosyl groups
IPT68_RS31095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPT68_RS31110	COG3467	pyridoxamine 5'-phosphate
IPT68_RS31120	COG0477	Major facilitator Superfamily
IPT68_RS31155	COG0588	phosphoglycerate mutase activity
IPT68_RS31160	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPT68_RS31165	COG0166	Belongs to the GPI family
IPT68_RS31180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPT68_RS31260	COG0395	ABC-type sugar transport system, permease component
IPT68_RS31275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS31280	COG1349	DNA-binding transcription factor activity
IPT68_RS31285	COG1486	melibiose metabolic process
IPT68_RS31305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IPT68_RS31345	COG3511	phospholipase C
IPT68_RS31370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IPT68_RS31390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPT68_RS31395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPT68_RS31400	COG3485	protocatechuate 3,4-dioxygenase
IPT68_RS31405	COG3485	protocatechuate 3,4-dioxygenase
IPT68_RS31440	COG1793	dna ligase
IPT68_RS31515	COG1834	amidinotransferase
IPT68_RS31520	COG0488	(ABC) transporter
IPT68_RS31535	COG1515	deoxyribonuclease V activity
IPT68_RS31545	COG3268	Saccharopine dehydrogenase
IPT68_RS31555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPT68_RS31560	COG0183	Belongs to the thiolase family
IPT68_RS31565	COG1024	Enoyl-CoA hydratase
IPT68_RS31565	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPT68_RS31575	COG1113	amino acid transport
IPT68_RS31580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPT68_RS31595	COG2936	dipeptidyl-peptidase activity
IPT68_RS31610	COG0488	(ABC) transporter
IPT68_RS31620	COG2183	response to ionizing radiation
IPT68_RS31630	COG4977	sequence-specific DNA binding
IPT68_RS31640	COG1024	Enoyl-CoA hydratase
IPT68_RS31655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPT68_RS31700	COG1134	teichoic acid transport
IPT68_RS31705	COG1562	ergosterol biosynthetic process
IPT68_RS31715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IPT68_RS31725	COG1657	PFAM Prenyltransferase squalene oxidase
IPT68_RS31740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPT68_RS31745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPT68_RS31765	COG2365	Tyrosine phosphatase family
IPT68_RS31770	COG0739	heme binding
IPT68_RS31775	COG2755	lipolytic protein G-D-S-L family
IPT68_RS31785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPT68_RS31820	COG1063	alcohol dehydrogenase
IPT68_RS31825	COG0156	8-amino-7-oxononanoate synthase activity
IPT68_RS31830	COG0583	DNA-binding transcription factor activity
IPT68_RS31940	COG0515	serine threonine protein kinase
IPT68_RS31940	COG2815	serine threonine protein kinase
IPT68_RS31975	COG2267	carboxylic ester hydrolase activity
IPT68_RS31990	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS32000	COG0183	Belongs to the thiolase family
IPT68_RS32010	COG1011	Hydrolase
IPT68_RS32040	COG0494	nUDIX hydrolase
IPT68_RS32050	COG2188	Transcriptional regulator
IPT68_RS32085	COG0076	glutamate decarboxylase activity
IPT68_RS32090	COG0673	inositol 2-dehydrogenase activity
IPT68_RS32105	COG3548	integral membrane protein
IPT68_RS32110	COG0673	inositol 2-dehydrogenase activity
IPT68_RS32115	COG1609	Transcriptional regulator
IPT68_RS32135	COG0477	Major facilitator Superfamily
IPT68_RS32155	COG2197	response regulator
IPT68_RS32180	COG2124	cytochrome p450
IPT68_RS32190	COG1846	Transcriptional regulator
IPT68_RS32200	COG2838	Isocitrate dehydrogenase
IPT68_RS32205	COG0668	transmembrane transport
IPT68_RS32210	COG1024	Enoyl-CoA hydratase
IPT68_RS32220	COG1132	(ABC) transporter
IPT68_RS32230	COG1764	response to oxidative stress
IPT68_RS32265	COG0488	(ABC) transporter
IPT68_RS32325	COG1349	DNA-binding transcription factor activity
IPT68_RS32335	COG0395	ABC-type sugar transport system, permease component
IPT68_RS32355	COG3328	transposase activity
IPT68_RS32405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IPT68_RS32420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IPT68_RS32440	COG0297	glycogen (starch) synthase activity
IPT68_RS32445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPT68_RS32495	COG1175	transmembrane transport
IPT68_RS32500	COG0395	ABC-type sugar transport system, permease component
IPT68_RS32545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPT68_RS32585	COG0531	amino acid
IPT68_RS32595	COG0726	polysaccharide deacetylase
IPT68_RS32635	COG0583	DNA-binding transcription factor activity
IPT68_RS32645	COG1053	succinate dehydrogenase
IPT68_RS32650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPT68_RS32665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPT68_RS32685	COG2182	Extracellular solute-binding protein
IPT68_RS32690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IPT68_RS32700	COG0121	glutamine amidotransferase
IPT68_RS32705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPT68_RS32765	COG1609	Transcriptional regulator
IPT68_RS32775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPT68_RS32785	COG0242	peptide deformylase activity
IPT68_RS32810	COG1881	PFAM PEBP family protein
IPT68_RS32830	COG0604	alcohol dehydrogenase
IPT68_RS32835	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS32845	COG0542	response to heat
IPT68_RS32860	COG1174	glycine betaine transport
IPT68_RS32880	COG1556	Lactate utilization protein
IPT68_RS32885	COG1139	Iron-sulfur cluster binding protein
IPT68_RS32890	COG0247	lactate metabolic process
IPT68_RS32895	COG1070	Carbohydrate kinase
IPT68_RS32900	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS32900	COG3347	Dehydrogenase
IPT68_RS32910	COG1129	ABC transporter
IPT68_RS32915	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPT68_RS32940	COG1609	Transcriptional regulator
IPT68_RS32965	COG2706	6-phosphogluconolactonase activity
IPT68_RS33005	COG1796	DNA polymerase
IPT68_RS33005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPT68_RS33010	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS33065	COG0435	Glutathione S-transferase
IPT68_RS33105	COG0667	Aldo Keto reductase
IPT68_RS33145	COG2910	NAD(P)H-binding
IPT68_RS33170	COG2890	protein-(glutamine-N5) methyltransferase activity
IPT68_RS33180	COG0655	NAD(P)H dehydrogenase (quinone) activity
IPT68_RS33190	COG0248	Ppx GppA phosphatase
IPT68_RS33230	COG1309	transcriptional regulator
IPT68_RS33250	COG0517	IMP dehydrogenase activity
IPT68_RS33275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IPT68_RS33295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPT68_RS33310	COG1132	(ABC) transporter
IPT68_RS33330	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS33405	COG0572	uridine kinase
IPT68_RS33420	COG3340	Belongs to the peptidase S51 family
IPT68_RS33460	COG2261	transglycosylase associated protein
IPT68_RS33480	COG2508	Transcriptional regulator
IPT68_RS33485	COG0410	ABC transporter
IPT68_RS33490	COG0411	ABC transporter
IPT68_RS33530	COG1132	(ABC) transporter
IPT68_RS33560	COG1028	Short-chain dehydrogenase reductase Sdr
IPT68_RS33600	COG0583	DNA-binding transcription factor activity