locus-tag	class	description
CP977_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS00255	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS00270	COG2318	DinB family
CP977_RS00275	COG0604	alcohol dehydrogenase
CP977_RS00355	COG3293	Transposase
CP977_RS00380	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CP977_RS00455	COG2770	Histidine kinase
CP977_RS00455	COG2208	phosphoserine phosphatase activity
CP977_RS00615	COG0697	spore germination
CP977_RS00620	COG2814	Major facilitator Superfamily
CP977_RS00670	COG1278	Cold shock
CP977_RS00710	COG3293	Transposase
CP977_RS00805	COG2826	transposase and inactivated derivatives, IS30 family
CP977_RS00840	COG0419	ATPase involved in DNA repair
CP977_RS01010	COG3328	transposase activity
CP977_RS01165	COG1674	ftsk spoiiie
CP977_RS01250	COG0464	growth
CP977_RS01300	COG0300	oxidoreductase activity
CP977_RS01340	COG2964	Protein conserved in bacteria
CP977_RS01370	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS01375	COG0477	Major facilitator Superfamily
CP977_RS01390	COG0515	serine threonine protein kinase
CP977_RS01435	COG1595	DNA-templated transcription, initiation
CP977_RS01520	COG2208	phosphoserine phosphatase activity
CP977_RS01560	COG1278	Cold shock
CP977_RS01565	COG0776	regulation of translation
CP977_RS01575	COG2205	protein histidine kinase activity
CP977_RS01595	COG2197	response regulator
CP977_RS01690	COG3629	intracellular signal transduction
CP977_RS01690	COG3903	Transcriptional regulator
CP977_RS01710	COG0300	oxidoreductase activity
CP977_RS01725	COG0515	serine threonine protein kinase
CP977_RS01725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS01740	COG1295	ribonuclease BN
CP977_RS01740	COG1959	2 iron, 2 sulfur cluster binding
CP977_RS01745	COG1846	Transcriptional regulator
CP977_RS01765	COG0604	alcohol dehydrogenase
CP977_RS01790	COG1309	transcriptional regulator
CP977_RS01860	COG2205	protein histidine kinase activity
CP977_RS01865	COG0745	RESPONSE REGULATOR receiver
CP977_RS01915	COG0736	holo-[acyl-carrier-protein] synthase activity
CP977_RS01950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP977_RS01955	COG0488	(ABC) transporter
CP977_RS02010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP977_RS02025	COG1595	DNA-templated transcription, initiation
CP977_RS02060	COG2249	NAD(P)H dehydrogenase (quinone) activity
CP977_RS02125	COG0667	Aldo Keto reductase
CP977_RS02170	COG0714	Associated with various cellular activities
CP977_RS02175	COG3864	Putative metallopeptidase domain
CP977_RS02200	COG0488	(ABC) transporter
CP977_RS02205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP977_RS02250	COG1819	glycosyl
CP977_RS02255	COG0586	Pfam SNARE associated Golgi protein
CP977_RS02265	COG2197	response regulator
CP977_RS02325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP977_RS02340	COG2326	polyphosphate kinase activity
CP977_RS02370	COG0671	phosphoesterase, PA-phosphatase related
CP977_RS02395	COG2267	carboxylic ester hydrolase activity
CP977_RS02405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP977_RS02410	COG0697	spore germination
CP977_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS02455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS02460	COG3251	PFAM MbtH domain protein
CP977_RS02480	COG0515	serine threonine protein kinase
CP977_RS02495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP977_RS02505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP977_RS02555	COG2814	Major facilitator Superfamily
CP977_RS02600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP977_RS02610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS02620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP977_RS02650	COG0714	Associated with various cellular activities
CP977_RS02655	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP977_RS02715	COG2814	Major facilitator Superfamily
CP977_RS02735	COG0546	phosphoglycolate phosphatase activity
CP977_RS02755	COG0745	RESPONSE REGULATOR receiver
CP977_RS02760	COG4251	negative regulation of phosphorylation
CP977_RS02765	COG0784	Response regulator, receiver
CP977_RS02795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP977_RS02795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP977_RS02815	COG2066	Belongs to the glutaminase family
CP977_RS02820	COG1024	Enoyl-CoA hydratase
CP977_RS02830	COG0328	RNA-DNA hybrid ribonuclease activity
CP977_RS02880	COG0252	asparaginase activity
CP977_RS02890	COG2356	endonuclease I
CP977_RS02895	COG0456	acetyltransferase
CP977_RS02900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CP977_RS02910	COG5285	phytanoyl-CoA dioxygenase
CP977_RS02915	COG1191	sigma factor activity
CP977_RS02930	COG0659	secondary active sulfate transmembrane transporter activity
CP977_RS03005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP977_RS03015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS03020	COG0601	transmembrane transport
CP977_RS03025	COG0747	negative chemotaxis
CP977_RS03050	COG3152	Membrane
CP977_RS03115	COG1357	PFAM Pentapeptide repeats (8 copies)
CP977_RS03130	COG1846	Transcriptional regulator
CP977_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS03145	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CP977_RS03150	COG0387	Pfam Sodium calcium exchanger
CP977_RS03160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP977_RS03165	COG0583	DNA-binding transcription factor activity
CP977_RS03170	COG0156	8-amino-7-oxononanoate synthase activity
CP977_RS03175	COG1063	alcohol dehydrogenase
CP977_RS03185	COG0515	serine threonine protein kinase
CP977_RS03215	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CP977_RS03230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP977_RS03235	COG1063	alcohol dehydrogenase
CP977_RS03240	COG0516	GMP reductase activity
CP977_RS03240	COG0517	IMP dehydrogenase activity
CP977_RS03250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS03250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP977_RS03255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP977_RS03265	COG1937	Protein conserved in bacteria
CP977_RS03270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CP977_RS03330	COG1309	transcriptional regulator
CP977_RS03335	COG0842	Transport permease protein
CP977_RS03335	COG1716	ATPase activity
CP977_RS03335	COG1131	(ABC) transporter
CP977_RS03365	COG1960	acyl-CoA dehydrogenase activity
CP977_RS03395	COG0516	GMP reductase activity
CP977_RS03395	COG0517	IMP dehydrogenase activity
CP977_RS03410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP977_RS03445	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS03450	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS03455	COG2172	sigma factor antagonist activity
CP977_RS03465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS03465	COG2205	protein histidine kinase activity
CP977_RS03515	COG2197	response regulator
CP977_RS03525	COG0475	glutathione-regulated potassium exporter activity
CP977_RS03525	COG0569	domain protein
CP977_RS03555	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS03585	COG4981	capsule polysaccharide biosynthetic process
CP977_RS03615	COG1742	UPF0060 membrane protein
CP977_RS03620	COG0789	Transcriptional regulator
CP977_RS03625	COG2376	Dihydroxyacetone kinase
CP977_RS03630	COG1461	Dihydroxyacetone kinase
CP977_RS03640	COG1902	pentaerythritol trinitrate reductase activity
CP977_RS03640	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP977_RS03675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP977_RS03685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP977_RS03685	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP977_RS03700	COG1686	Belongs to the peptidase S11 family
CP977_RS03705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP977_RS03750	COG2838	Isocitrate dehydrogenase
CP977_RS03775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CP977_RS03785	COG3739	integral membrane protein
CP977_RS03790	COG1278	Cold shock
CP977_RS03795	COG0513	Belongs to the DEAD box helicase family
CP977_RS03810	COG3629	intracellular signal transduction
CP977_RS03810	COG3903	Transcriptional regulator
CP977_RS03825	COG3835	regulator
CP977_RS03835	COG0243	molybdopterin cofactor binding
CP977_RS03850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS03900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP977_RS03905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP977_RS03910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP977_RS03915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP977_RS03930	COG1120	ATPase activity
CP977_RS03935	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS03945	COG1132	(ABC) transporter
CP977_RS03950	COG1132	(ABC) transporter
CP977_RS03955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS03960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP977_RS03965	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP977_RS03975	COG1846	Transcriptional regulator
CP977_RS03990	COG1120	ATPase activity
CP977_RS04000	COG0154	amidase activity
CP977_RS04020	COG1120	ATPase activity
CP977_RS04025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS04035	COG4753	response regulator
CP977_RS04035	COG2207	Transcriptional regulator
CP977_RS04050	COG1535	isochorismatase
CP977_RS04050	COG3433	isochorismatase activity
CP977_RS04065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS04075	COG1169	isochorismate synthase
CP977_RS04080	COG1021	2,3-dihydroxybenzoate-AMP ligase
CP977_RS04085	COG3433	isochorismatase activity
CP977_RS04085	COG1535	isochorismatase
CP977_RS04090	COG2271	Major facilitator Superfamily
CP977_RS04100	COG2340	Cysteine-rich secretory protein family
CP977_RS04110	COG3848	Pyruvate phosphate dikinase
CP977_RS04110	COG0574	Belongs to the PEP-utilizing enzyme family
CP977_RS04120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP977_RS04140	COG1191	sigma factor activity
CP977_RS04165	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS04175	COG5002	protein histidine kinase activity
CP977_RS04175	COG2205	protein histidine kinase activity
CP977_RS04175	COG0784	Response regulator, receiver
CP977_RS04225	COG0395	ABC-type sugar transport system, permease component
CP977_RS04230	COG1175	transmembrane transport
CP977_RS04240	COG2188	Transcriptional regulator
CP977_RS04300	COG0477	Major facilitator Superfamily
CP977_RS04330	COG2867	negative regulation of translational initiation
CP977_RS04400	COG2723	6-phospho-beta-galactosidase activity
CP977_RS04405	COG0395	ABC-type sugar transport system, permease component
CP977_RS04410	COG1175	transmembrane transport
CP977_RS04415	COG2182	Extracellular solute-binding protein
CP977_RS04430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CP977_RS04440	COG4221	oxidoreductase activity
CP977_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS04530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CP977_RS04535	COG0463	Glycosyl transferase, family 2
CP977_RS04550	COG0464	growth
CP977_RS04560	COG1349	DNA-binding transcription factor activity
CP977_RS04600	COG1940	carbohydrate kinase activity
CP977_RS04605	COG2223	nitrite transmembrane transporter activity
CP977_RS04635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS04640	COG1660	Displays ATPase and GTPase activities
CP977_RS04665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP977_RS04725	COG0671	phosphoesterase, PA-phosphatase related
CP977_RS04745	COG0640	Transcriptional regulator
CP977_RS04750	COG1902	pentaerythritol trinitrate reductase activity
CP977_RS04760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP977_RS04765	COG2971	BadF BadG BcrA BcrD
CP977_RS04775	COG2706	6-phosphogluconolactonase activity
CP977_RS04795	COG3585	molybdate ion transport
CP977_RS04830	COG0006	proline dipeptidase activity
CP977_RS04840	COG1505	serine-type exopeptidase activity
CP977_RS04845	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CP977_RS04870	COG2072	flavoprotein involved in K transport
CP977_RS04875	COG1132	(ABC) transporter
CP977_RS04885	COG0277	FAD linked oxidase domain protein
CP977_RS04890	COG0673	inositol 2-dehydrogenase activity
CP977_RS04895	COG1132	(ABC) transporter
CP977_RS04900	COG1132	(ABC) transporter
CP977_RS04915	COG1946	Acyl-CoA thioesterase
CP977_RS04930	COG0386	Belongs to the glutathione peroxidase family
CP977_RS04935	COG2890	protein-(glutamine-N5) methyltransferase activity
CP977_RS04990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CP977_RS05035	COG1960	acyl-CoA dehydrogenase activity
CP977_RS05045	COG0242	peptide deformylase activity
CP977_RS05055	COG3442	glutamine amidotransferase
CP977_RS05060	COG0205	6-phosphofructokinase activity
CP977_RS05080	COG0204	Acyl-transferase
CP977_RS05095	COG0829	nickel cation binding
CP977_RS05100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CP977_RS05105	COG0830	nickel cation binding
CP977_RS05110	COG0804	urea catabolic process
CP977_RS05115	COG0832	Belongs to the urease beta subunit family
CP977_RS05120	COG0831	urea catabolic process
CP977_RS05130	COG0740	serine-type endopeptidase activity
CP977_RS05155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP977_RS05160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP977_RS05165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP977_RS05170	COG2226	methyltransferase
CP977_RS05200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP977_RS05205	COG3663	DNA glycosylase
CP977_RS05210	COG1940	carbohydrate kinase activity
CP977_RS05215	COG2188	Transcriptional regulator
CP977_RS05225	COG1595	DNA-templated transcription, initiation
CP977_RS05240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP977_RS05245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP977_RS05255	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP977_RS05265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP977_RS05270	COG1121	(ABC) transporter
CP977_RS05290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS05295	COG1120	ATPase activity
CP977_RS05325	COG1132	(ABC) transporter
CP977_RS05370	COG0626	cystathionine gamma-synthase activity
CP977_RS05385	COG1522	sequence-specific DNA binding
CP977_RS05390	COG0419	ATPase involved in DNA repair
CP977_RS05395	COG0420	3'-5' exonuclease activity
CP977_RS05400	COG1739	Uncharacterized protein family UPF0029
CP977_RS05405	COG1832	CoA-binding protein
CP977_RS05415	COG0110	maltose O-acetyltransferase activity
CP977_RS05460	COG1968	undecaprenyl-diphosphatase activity
CP977_RS05465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP977_RS05485	COG2318	DinB family
CP977_RS05500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP977_RS05535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CP977_RS05560	COG3321	synthase
CP977_RS05560	COG0604	alcohol dehydrogenase
CP977_RS05585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS05590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS05600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS05655	COG3321	synthase
CP977_RS05655	COG0604	alcohol dehydrogenase
CP977_RS05720	COG0702	epimerase
CP977_RS05725	COG1846	Transcriptional regulator
CP977_RS05730	COG2409	Drug exporters of the RND superfamily
CP977_RS05735	COG1595	DNA-templated transcription, initiation
CP977_RS05790	COG0583	DNA-binding transcription factor activity
CP977_RS05795	COG0697	spore germination
CP977_RS05830	COG1695	Transcriptional regulator
CP977_RS05880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP977_RS05880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP977_RS05890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CP977_RS05930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP977_RS05965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP977_RS05990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP977_RS06000	COG2816	NAD+ diphosphatase activity
CP977_RS06005	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CP977_RS06020	COG2018	Roadblock/LC7 domain
CP977_RS06055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CP977_RS06060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CP977_RS06065	COG1984	allophanate hydrolase subunit 2
CP977_RS06105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP977_RS06110	COG2364	Membrane
CP977_RS06120	COG2270	Major facilitator Superfamily
CP977_RS06135	COG1216	Glycosyl transferase, family 2
CP977_RS06160	COG1960	acyl-CoA dehydrogenase activity
CP977_RS06180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP977_RS06180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP977_RS06205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP977_RS06210	COG0140	phosphoribosyl-ATP diphosphatase activity
CP977_RS06215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP977_RS06220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP977_RS06220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CP977_RS06225	COG3201	nicotinamide mononucleotide transporter
CP977_RS06245	COG1940	carbohydrate kinase activity
CP977_RS06245	COG1846	Transcriptional regulator
CP977_RS06255	COG2233	PERMEase
CP977_RS06270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP977_RS06285	COG0531	amino acid
CP977_RS06305	COG2732	(Barnase) inhibitor
CP977_RS06315	COG2390	Transcriptional regulator
CP977_RS06320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP977_RS06340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP977_RS06355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP977_RS06370	COG0194	GDP metabolic process
CP977_RS06380	COG0284	orotidine-5'-phosphate decarboxylase activity
CP977_RS06385	COG0167	dihydroorotate dehydrogenase activity
CP977_RS06390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CP977_RS06395	COG0505	Belongs to the CarA family
CP977_RS06405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP977_RS06410	COG0540	Belongs to the ATCase OTCase family
CP977_RS06415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CP977_RS06425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP977_RS06430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP977_RS06435	COG0006	proline dipeptidase activity
CP977_RS06445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP977_RS06450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP977_RS06455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP977_RS06460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP977_RS06470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP977_RS06475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP977_RS06485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP977_RS06490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP977_RS06510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP977_RS06530	COG0124	histidyl-tRNA synthetase
CP977_RS06545	COG1196	nuclear chromosome segregation
CP977_RS06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP977_RS06555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP977_RS06560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP977_RS06565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP977_RS06575	COG2255	four-way junction helicase activity
CP977_RS06580	COG0632	four-way junction helicase activity
CP977_RS06585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP977_RS06590	COG0217	transcriptional regulatory protein
CP977_RS06595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CP977_RS06600	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CP977_RS06610	COG0438	transferase activity, transferring glycosyl groups
CP977_RS06615	COG1560	Kdo2-lipid A biosynthetic process
CP977_RS06620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP977_RS06645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP977_RS06660	COG5002	protein histidine kinase activity
CP977_RS06660	COG2176	DNA-directed DNA polymerase activity
CP977_RS06715	COG0454	-acetyltransferase
CP977_RS06715	COG0456	acetyltransferase
CP977_RS06720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP977_RS06725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP977_RS06775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP977_RS06775	COG1648	precorrin-2 dehydrogenase activity
CP977_RS06780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP977_RS06795	COG1464	Belongs to the NlpA lipoprotein family
CP977_RS06800	COG2011	ABC-type metal ion transport system permease component
CP977_RS06805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CP977_RS06835	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS06835	COG0204	Acyl-transferase
CP977_RS06840	COG0477	Major facilitator Superfamily
CP977_RS06855	COG0165	Argininosuccinate lyase
CP977_RS06870	COG1438	arginine binding
CP977_RS06875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP977_RS06880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP977_RS06885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP977_RS06890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CP977_RS06900	COG0137	argininosuccinate synthase activity
CP977_RS06905	COG2813	Specifically methylates the guanine in position
CP977_RS06930	COG0697	spore germination
CP977_RS06940	COG1649	PFAM Uncharacterised BCR, COG1649
CP977_RS06950	COG1051	belongs to the nudix hydrolase family
CP977_RS06965	COG0072	phenylalanine-tRNA ligase activity
CP977_RS06965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP977_RS06970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP977_RS06980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP977_RS06985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP977_RS06990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP977_RS06995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP977_RS07030	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS07035	COG0174	glutamine synthetase
CP977_RS07045	COG1113	amino acid transport
CP977_RS07050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP977_RS07100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP977_RS07135	COG2124	cytochrome p450
CP977_RS07150	COG0805	protein transport
CP977_RS07155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP977_RS07175	COG2378	regulation of single-species biofilm formation
CP977_RS07190	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP977_RS07200	COG1609	Transcriptional regulator
CP977_RS07205	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP977_RS07210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CP977_RS07220	COG4122	O-methyltransferase activity
CP977_RS07225	COG1222	aaa ATPase
CP977_RS07245	COG1994	Peptidase M50
CP977_RS07245	COG0517	IMP dehydrogenase activity
CP977_RS07255	COG2197	response regulator
CP977_RS07265	COG0747	negative chemotaxis
CP977_RS07275	COG0646	methionine synthase
CP977_RS07275	COG1410	methionine synthase
CP977_RS07280	COG1414	Transcriptional regulator
CP977_RS07285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CP977_RS07290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP977_RS07295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP977_RS07305	COG0215	cysteine-tRNA ligase activity
CP977_RS07325	COG0598	Magnesium transport protein CorA
CP977_RS07335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS07340	COG0667	Aldo Keto reductase
CP977_RS07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP977_RS07380	COG0564	pseudouridine synthase activity
CP977_RS07395	COG1113	amino acid transport
CP977_RS07400	COG2186	Transcriptional regulator
CP977_RS07405	COG3265	gluconokinase activity
CP977_RS07435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP977_RS07440	COG2149	membrane
CP977_RS07465	COG1960	acyl-CoA dehydrogenase activity
CP977_RS07480	COG3876	Protein conserved in bacteria
CP977_RS07525	COG1960	acyl-CoA dehydrogenase activity
CP977_RS07555	COG4566	intracellular signal transduction
CP977_RS07560	COG1404	Belongs to the peptidase S8 family
CP977_RS07565	COG0747	negative chemotaxis
CP977_RS07580	COG1309	transcriptional regulator
CP977_RS07610	COG2851	Citrate transporter
CP977_RS07615	COG0243	molybdopterin cofactor binding
CP977_RS07620	COG2072	flavoprotein involved in K transport
CP977_RS07630	COG1309	transcriptional regulator
CP977_RS07650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP977_RS07655	COG2188	Transcriptional regulator
CP977_RS07665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS07680	COG2755	lipolytic protein G-D-S-L family
CP977_RS07695	COG0726	polysaccharide deacetylase
CP977_RS07705	COG1725	Transcriptional regulator
CP977_RS07740	COG4565	transcriptional regulatory protein
CP977_RS07770	COG1126	abc transporter atp-binding protein
CP977_RS07780	COG0765	amino acid transport
CP977_RS07800	COG1799	cell septum assembly
CP977_RS07805	COG0477	Major facilitator Superfamily
CP977_RS07810	COG0671	phosphoesterase, PA-phosphatase related
CP977_RS07825	COG0438	transferase activity, transferring glycosyl groups
CP977_RS07830	COG3583	domain protein
CP977_RS07845	COG1160	GTP binding
CP977_RS07855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP977_RS07895	COG3201	nicotinamide mononucleotide transporter
CP977_RS07900	COG1187	pseudouridine synthase activity
CP977_RS07905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP977_RS07910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP977_RS07925	COG0686	Belongs to the AlaDH PNT family
CP977_RS07935	COG0494	nUDIX hydrolase
CP977_RS07940	COG0504	CTP synthase activity
CP977_RS07945	COG3387	PFAM Glycoside hydrolase 15-related
CP977_RS07955	COG0577	efflux transmembrane transporter activity
CP977_RS07955	COG1136	(ABC) transporter
CP977_RS07965	COG2197	response regulator
CP977_RS07980	COG0297	glycogen (starch) synthase activity
CP977_RS07990	COG0497	DNA recombination
CP977_RS07995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP977_RS08015	COG1120	ATPase activity
CP977_RS08020	COG0647	UMP catabolic process
CP977_RS08055	COG2094	Belongs to the DNA glycosylase MPG family
CP977_RS08065	COG1881	PFAM PEBP family protein
CP977_RS08090	COG1119	ATPase activity
CP977_RS08105	COG2197	response regulator
CP977_RS08115	COG4221	oxidoreductase activity
CP977_RS08120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CP977_RS08130	COG1716	ATPase activity
CP977_RS08130	COG0842	Transport permease protein
CP977_RS08130	COG1131	(ABC) transporter
CP977_RS08135	COG0560	Phosphoserine phosphatase
CP977_RS08135	COG3830	Belongs to the UPF0237 family
CP977_RS08155	COG2186	Transcriptional regulator
CP977_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS08185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP977_RS08190	COG2261	transglycosylase associated protein
CP977_RS08205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP977_RS08210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP977_RS08225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS08250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP977_RS08265	COG3387	PFAM Glycoside hydrolase 15-related
CP977_RS08305	COG1024	Enoyl-CoA hydratase
CP977_RS08315	COG0488	(ABC) transporter
CP977_RS08350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CP977_RS08355	COG1492	cobalamin metabolic process
CP977_RS08370	COG1797	cobyrinic acid a,c-diamide synthase activity
CP977_RS08390	COG2375	cellular response to nickel ion
CP977_RS08390	COG1132	(ABC) transporter
CP977_RS08410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CP977_RS08430	COG3973	AAA domain
CP977_RS08455	COG4585	Histidine kinase
CP977_RS08460	COG2197	response regulator
CP977_RS08470	COG0768	penicillin binding
CP977_RS08485	COG3290	protein histidine kinase activity
CP977_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS08530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP977_RS08545	COG2171	N-acyltransferase activity
CP977_RS08550	COG3226	Transcriptional regulator
CP977_RS08555	COG2076	Multidrug Resistance protein
CP977_RS08570	COG2151	metal-sulfur cluster biosynthetic enzyme
CP977_RS08575	COG0822	iron-sulfur transferase activity
CP977_RS08580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP977_RS08585	COG0396	ATPase activity
CP977_RS08595	COG0719	Fe-S assembly protein
CP977_RS08610	COG1131	(ABC) transporter
CP977_RS08630	COG0109	protoheme IX farnesyltransferase activity
CP977_RS08640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP977_RS08655	COG0363	glucosamine-6-phosphate deaminase activity
CP977_RS08670	COG0166	Belongs to the GPI family
CP977_RS08680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP977_RS08685	COG0149	triose-phosphate isomerase activity
CP977_RS08690	COG0126	phosphoglycerate kinase activity
CP977_RS08695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP977_RS08705	COG1481	regulation of sporulation
CP977_RS08710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP977_RS08715	COG1660	Displays ATPase and GTPase activities
CP977_RS08745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP977_RS08760	COG0477	Major facilitator Superfamily
CP977_RS08780	COG0556	nucleotide-excision repair
CP977_RS08795	COG0477	Major facilitator Superfamily
CP977_RS08805	COG2313	pseudouridylate synthase activity
CP977_RS08810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP977_RS08835	COG1733	regulation of RNA biosynthetic process
CP977_RS08840	COG0436	Aminotransferase
CP977_RS08865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP977_RS08885	COG0237	dephospho-CoA kinase activity
CP977_RS08900	COG2226	methyltransferase
CP977_RS08905	COG1643	Atp-dependent helicase
CP977_RS08935	COG2050	protein possibly involved in aromatic compounds catabolism
CP977_RS08985	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CP977_RS08995	COG0737	Belongs to the 5'-nucleotidase family
CP977_RS09015	COG0287	Prephenate dehydrogenase
CP977_RS09015	COG1605	Chorismate mutase
CP977_RS09025	COG4977	sequence-specific DNA binding
CP977_RS09025	COG1917	Cupin 2, conserved barrel domain protein
CP977_RS09065	COG0069	glutamate synthase activity
CP977_RS09065	COG0070	glutamate synthase
CP977_RS09065	COG0067	glutamate synthase
CP977_RS09075	COG1397	ADP-ribosylglycohydrolase
CP977_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP977_RS09100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS09110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP977_RS09120	COG0159	tryptophan synthase activity
CP977_RS09125	COG0133	tryptophan synthase activity
CP977_RS09135	COG0134	indole-3-glycerol-phosphate synthase activity
CP977_RS09160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP977_RS09180	COG0107	imidazoleglycerol-phosphate synthase activity
CP977_RS09185	COG0251	oxidation-reduction process
CP977_RS09190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP977_RS09195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP977_RS09200	COG0131	Imidazoleglycerol-phosphate dehydratase
CP977_RS09205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP977_RS09210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP977_RS09230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CP977_RS09250	COG1432	Conserved Protein
CP977_RS09255	COG0587	DNA-directed DNA polymerase activity
CP977_RS09305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP977_RS09320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP977_RS09335	COG1799	cell septum assembly
CP977_RS09345	COG1496	oxidoreductase activity
CP977_RS09355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP977_RS09360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP977_RS09370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP977_RS09375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP977_RS09385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP977_RS09390	COG0768	penicillin binding
CP977_RS09400	COG0275	rRNA processing
CP977_RS09410	COG0714	Associated with various cellular activities
CP977_RS09430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP977_RS09440	COG1131	(ABC) transporter
CP977_RS09445	COG1511	domain protein
CP977_RS09450	COG1309	transcriptional regulator
CP977_RS09475	COG0352	thiamine-phosphate diphosphorylase activity
CP977_RS09490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS09490	COG2022	thiamine diphosphate biosynthetic process
CP977_RS09500	COG2022	thiamine diphosphate biosynthetic process
CP977_RS09505	COG2815	serine threonine protein kinase
CP977_RS09505	COG0515	serine threonine protein kinase
CP977_RS09510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CP977_RS09515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP977_RS09520	COG2193	ferroxidase activity
CP977_RS09525	COG0243	molybdopterin cofactor binding
CP977_RS09530	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP977_RS09550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP977_RS09555	COG2197	response regulator
CP977_RS09560	COG4585	Histidine kinase
CP977_RS09585	COG1940	carbohydrate kinase activity
CP977_RS09595	COG0003	Pfam Anion-transporting ATPase
CP977_RS09615	COG0438	transferase activity, transferring glycosyl groups
CP977_RS09650	COG0705	Rhomboid family
CP977_RS09660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP977_RS09665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP977_RS09670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP977_RS09675	COG0723	plastoquinol--plastocyanin reductase activity
CP977_RS09680	COG2010	Cytochrome c
CP977_RS09685	COG1845	cytochrome c oxidase, subunit III
CP977_RS09695	COG1376	ErfK ybiS ycfS ynhG family protein
CP977_RS09705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP977_RS09710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP977_RS09715	COG1104	cysteine desulfurase activity
CP977_RS09720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP977_RS09745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CP977_RS09750	COG2197	response regulator
CP977_RS09755	COG4585	Histidine kinase
CP977_RS09775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP977_RS09780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP977_RS09795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CP977_RS09800	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP977_RS09800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP977_RS09815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CP977_RS09845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP977_RS09850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP977_RS09855	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP977_RS09865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP977_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS09915	COG0321	lipoyl(octanoyl) transferase activity
CP977_RS09920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP977_RS09990	COG0745	RESPONSE REGULATOR receiver
CP977_RS10010	COG2365	Tyrosine phosphatase family
CP977_RS10030	COG1309	transcriptional regulator
CP977_RS10050	COG0366	Alpha amylase catalytic
CP977_RS10055	COG0395	ABC-type sugar transport system, permease component
CP977_RS10060	COG1175	transmembrane transport
CP977_RS10065	COG2182	Extracellular solute-binding protein
CP977_RS10070	COG1609	Transcriptional regulator
CP977_RS10085	COG0531	amino acid
CP977_RS10095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP977_RS10145	COG0174	glutamine synthetase
CP977_RS10180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP977_RS10180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP977_RS10185	COG2814	Major facilitator Superfamily
CP977_RS10195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP977_RS10215	COG1994	Peptidase M50
CP977_RS10270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP977_RS10275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS10280	COG1120	ATPase activity
CP977_RS10285	COG0672	)-iron permease
CP977_RS10305	COG1834	amidinotransferase
CP977_RS10325	COG2814	Major facilitator Superfamily
CP977_RS10335	COG3540	Alkaline phosphatase
CP977_RS10380	COG3022	response to hydroperoxide
CP977_RS10385	COG0800	Aldolase
CP977_RS10405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CP977_RS10415	COG2030	dehydratase
CP977_RS10425	COG2197	response regulator
CP977_RS10430	COG0596	Alpha beta hydrolase
CP977_RS10500	COG0860	N-Acetylmuramoyl-L-alanine amidase
CP977_RS10525	COG0438	transferase activity, transferring glycosyl groups
CP977_RS10530	COG1309	transcriptional regulator
CP977_RS10555	COG3845	ABC transporter
CP977_RS10575	COG4122	O-methyltransferase activity
CP977_RS10640	COG1234	tRNA 3'-trailer cleavage
CP977_RS10700	COG1358	cellular component organization or biogenesis
CP977_RS10745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CP977_RS10755	COG0477	Major facilitator Superfamily
CP977_RS10760	COG1309	transcriptional regulator
CP977_RS10775	COG4585	Histidine kinase
CP977_RS10780	COG2197	response regulator
CP977_RS10795	COG0667	Aldo Keto reductase
CP977_RS10800	COG0789	Transcriptional regulator
CP977_RS10815	COG2205	protein histidine kinase activity
CP977_RS10820	COG0745	RESPONSE REGULATOR receiver
CP977_RS10865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP977_RS10870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP977_RS10875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP977_RS10895	COG1309	transcriptional regulator
CP977_RS10925	COG1764	response to oxidative stress
CP977_RS10930	COG2130	NADP-dependent
CP977_RS10960	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS10965	COG0477	Major facilitator Superfamily
CP977_RS10985	COG1846	Transcriptional regulator
CP977_RS10990	COG1764	response to oxidative stress
CP977_RS11010	COG0681	Belongs to the peptidase S26 family
CP977_RS11080	COG1070	Carbohydrate kinase
CP977_RS11100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP977_RS11105	COG0358	DNA primase activity
CP977_RS11115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP977_RS11135	COG2949	membrane
CP977_RS11140	COG0243	molybdopterin cofactor binding
CP977_RS11185	COG1017	nitric oxide dioxygenase activity
CP977_RS11185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP977_RS11190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP977_RS11195	COG2146	nitrite reductase [NAD(P)H] activity
CP977_RS11195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP977_RS11200	COG2146	nitrite reductase [NAD(P)H] activity
CP977_RS11200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP977_RS11205	COG1309	transcriptional regulator
CP977_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS11240	COG0574	Belongs to the PEP-utilizing enzyme family
CP977_RS11240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP977_RS11255	COG0667	Aldo Keto reductase
CP977_RS11265	COG0423	glycine-tRNA ligase activity
CP977_RS11270	COG3443	Belongs to the bacterial solute-binding protein 9 family
CP977_RS11270	COG0803	Belongs to the bacterial solute-binding protein 9 family
CP977_RS11280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CP977_RS11290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP977_RS11295	COG1381	Involved in DNA repair and RecF pathway recombination
CP977_RS11340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP977_RS11355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP977_RS11365	COG2315	Protein conserved in bacteria
CP977_RS11375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP977_RS11385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CP977_RS11385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CP977_RS11395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP977_RS11400	COG1234	tRNA 3'-trailer cleavage
CP977_RS11405	COG0537	adenosine 5'-monophosphoramidase activity
CP977_RS11415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP977_RS11435	COG0484	heat shock protein binding
CP977_RS11440	COG1420	regulation of RNA biosynthetic process
CP977_RS11465	COG0481	GTPase activity
CP977_RS11470	COG0268	Binds directly to 16S ribosomal RNA
CP977_RS11485	COG2353	YceI-like domain
CP977_RS11500	COG1555	photosystem II stabilization
CP977_RS11500	COG1596	polysaccharide export
CP977_RS11505	COG1307	EDD domain protein, DegV family
CP977_RS11515	COG0495	leucyl-tRNA aminoacylation
CP977_RS11545	COG0588	phosphoglycerate mutase activity
CP977_RS11550	COG0799	negative regulation of ribosome biogenesis
CP977_RS11560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP977_RS11570	COG0501	Belongs to the peptidase M48B family
CP977_RS11585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP977_RS11595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP977_RS11605	COG0463	Glycosyl transferase, family 2
CP977_RS11615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP977_RS11620	COG0438	transferase activity, transferring glycosyl groups
CP977_RS11635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP977_RS11640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP977_RS11645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP977_RS11650	COG1530	ribonuclease E activity
CP977_RS11675	COG0772	Belongs to the SEDS family
CP977_RS11680	COG0768	penicillin binding
CP977_RS11695	COG1077	Cell shape determining protein MreB Mrl
CP977_RS11700	COG0105	UTP biosynthetic process
CP977_RS11710	COG0285	dihydrofolate synthase activity
CP977_RS11720	COG0525	valine-tRNA ligase activity
CP977_RS11730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP977_RS11735	COG0740	serine-type endopeptidase activity
CP977_RS11740	COG0740	serine-type endopeptidase activity
CP977_RS11745	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP977_RS11765	COG3594	Acyltransferase
CP977_RS11775	COG4552	Acetyltransferase involved in intracellular survival and related
CP977_RS11795	COG1268	BioY protein
CP977_RS11800	COG1113	amino acid transport
CP977_RS11805	COG1113	amino acid transport
CP977_RS11810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CP977_RS11815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CP977_RS11850	COG2514	catechol 2,3-dioxygenase activity
CP977_RS11875	COG4266	Belongs to the allantoicase family
CP977_RS11885	COG0697	spore germination
CP977_RS11890	COG1846	Transcriptional regulator
CP977_RS11910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP977_RS11910	COG3291	Pkd domain containing protein
CP977_RS11920	COG0668	transmembrane transport
CP977_RS11930	COG1653	transport
CP977_RS11935	COG1175	transmembrane transport
CP977_RS11940	COG0395	ABC-type sugar transport system, permease component
CP977_RS11945	COG1486	melibiose metabolic process
CP977_RS11960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS11990	COG2346	COG2346, Truncated hemoglobins
CP977_RS12005	COG0577	efflux transmembrane transporter activity
CP977_RS12005	COG1136	(ABC) transporter
CP977_RS12030	COG0629	single-stranded DNA binding
CP977_RS12060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP977_RS12090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CP977_RS12095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CP977_RS12100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CP977_RS12155	COG0454	-acetyltransferase
CP977_RS12155	COG0456	acetyltransferase
CP977_RS12165	COG3962	Belongs to the TPP enzyme family
CP977_RS12170	COG3718	enzyme involved in inositol metabolism
CP977_RS12175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP977_RS12190	COG2409	Drug exporters of the RND superfamily
CP977_RS12215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CP977_RS12235	COG0673	inositol 2-dehydrogenase activity
CP977_RS12240	COG1609	Transcriptional regulator
CP977_RS12255	COG4585	Histidine kinase
CP977_RS12260	COG2197	response regulator
CP977_RS12270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP977_RS12280	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP977_RS12295	COG0477	Major facilitator Superfamily
CP977_RS12310	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CP977_RS12315	COG0309	Hydrogenase expression formation protein (HypE)
CP977_RS12320	COG1335	isochorismatase
CP977_RS12340	COG0583	DNA-binding transcription factor activity
CP977_RS12345	COG1472	Belongs to the glycosyl hydrolase 3 family
CP977_RS12420	COG1946	Acyl-CoA thioesterase
CP977_RS12435	COG1309	transcriptional regulator
CP977_RS12440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP977_RS12455	COG1960	acyl-CoA dehydrogenase activity
CP977_RS12470	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CP977_RS12535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP977_RS12545	COG0589	response to stress
CP977_RS12555	COG4977	sequence-specific DNA binding
CP977_RS12560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CP977_RS12570	COG3469	chitinase activity
CP977_RS12580	COG0745	RESPONSE REGULATOR receiver
CP977_RS12605	COG0406	alpha-ribazole phosphatase activity
CP977_RS12670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS12685	COG3397	chitin binding
CP977_RS12755	COG2188	Transcriptional regulator
CP977_RS12770	COG1940	carbohydrate kinase activity
CP977_RS12775	COG0673	inositol 2-dehydrogenase activity
CP977_RS12780	COG4702	Belongs to the UPF0303 family
CP977_RS12790	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP977_RS12795	COG0706	membrane insertase activity
CP977_RS12820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CP977_RS12870	COG2733	membrane
CP977_RS12875	COG4555	ABC transporter
CP977_RS12890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP977_RS12915	COG0477	Major facilitator Superfamily
CP977_RS12925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP977_RS12935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP977_RS12940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP977_RS12945	COG1263	PTS System
CP977_RS12950	COG1263	PTS System
CP977_RS12955	COG1234	tRNA 3'-trailer cleavage
CP977_RS12975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CP977_RS12980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS12985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP977_RS12995	COG1113	amino acid transport
CP977_RS13005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP977_RS13015	COG1335	isochorismatase
CP977_RS13050	COG0277	FAD linked oxidase domain protein
CP977_RS13060	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CP977_RS13100	COG3654	unkown
CP977_RS13150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP977_RS13165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP977_RS13170	COG0395	ABC-type sugar transport system, permease component
CP977_RS13195	COG1678	Uncharacterized ACR, COG1678
CP977_RS13200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP977_RS13205	COG0776	regulation of translation
CP977_RS13215	COG3973	AAA domain
CP977_RS13215	COG3973	AAA domain
CP977_RS13230	COG2223	nitrite transmembrane transporter activity
CP977_RS13235	COG0583	DNA-binding transcription factor activity
CP977_RS13250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP977_RS13255	COG0793	Belongs to the peptidase S41A family
CP977_RS13265	COG2884	Cell division ATP-binding protein ftsE
CP977_RS13280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP977_RS13285	COG0515	serine threonine protein kinase
CP977_RS13290	COG0515	serine threonine protein kinase
CP977_RS13300	COG1653	transport
CP977_RS13305	COG1175	transmembrane transport
CP977_RS13310	COG0395	ABC-type sugar transport system, permease component
CP977_RS13315	COG1309	transcriptional regulator
CP977_RS13330	COG2902	Dehydrogenase
CP977_RS13355	COG0653	protein targeting
CP977_RS13365	COG3214	Protein conserved in bacteria
CP977_RS13370	COG2197	response regulator
CP977_RS13375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP977_RS13385	COG0823	Involved in the tonB-independent uptake of proteins
CP977_RS13390	COG5000	phosphorelay sensor kinase activity
CP977_RS13390	COG5002	protein histidine kinase activity
CP977_RS13395	COG0745	RESPONSE REGULATOR receiver
CP977_RS13415	COG0714	Associated with various cellular activities
CP977_RS13460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP977_RS13470	COG1482	cell wall glycoprotein biosynthetic process
CP977_RS13480	COG2835	tetraacyldisaccharide 4'-kinase activity
CP977_RS13485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP977_RS13520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CP977_RS13525	COG0778	Nitroreductase
CP977_RS13525	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CP977_RS13570	COG1316	TRANSCRIPTIONal
CP977_RS13575	COG1607	acyl-coa hydrolase
CP977_RS13580	COG1316	TRANSCRIPTIONal
CP977_RS13590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP977_RS13625	COG2205	protein histidine kinase activity
CP977_RS13630	COG0745	RESPONSE REGULATOR receiver
CP977_RS13635	COG3104	oligopeptide transport
CP977_RS13645	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS13650	COG1191	sigma factor activity
CP977_RS13655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP977_RS13685	COG1216	Glycosyl transferase, family 2
CP977_RS13685	COG0463	Glycosyl transferase, family 2
CP977_RS13710	COG0494	nUDIX hydrolase
CP977_RS13720	COG1228	amidohydrolase
CP977_RS13735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CP977_RS13780	COG2755	lipolytic protein G-D-S-L family
CP977_RS13785	COG0183	Belongs to the thiolase family
CP977_RS13815	COG1136	(ABC) transporter
CP977_RS13820	COG0577	efflux transmembrane transporter activity
CP977_RS13820	COG1136	(ABC) transporter
CP977_RS13825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP977_RS13830	COG1252	NADH dehydrogenase
CP977_RS13850	COG0148	phosphopyruvate hydratase activity
CP977_RS13930	COG0545	Peptidyl-prolyl cis-trans isomerase
CP977_RS14010	COG0577	efflux transmembrane transporter activity
CP977_RS14015	COG1136	(ABC) transporter
CP977_RS14020	COG0477	Major facilitator Superfamily
CP977_RS14060	COG4585	Histidine kinase
CP977_RS14075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP977_RS14080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP977_RS14085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP977_RS14090	COG0193	aminoacyl-tRNA hydrolase activity
CP977_RS14105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CP977_RS14125	COG4106	trans-aconitate 2-methyltransferase activity
CP977_RS14130	COG1846	Transcriptional regulator
CP977_RS14135	COG2197	response regulator
CP977_RS14140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CP977_RS14170	COG0488	(ABC) transporter
CP977_RS14195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP977_RS14200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP977_RS14210	COG0084	hydrolase, TatD family'
CP977_RS14240	COG0442	prolyl-tRNA aminoacylation
CP977_RS14250	COG2188	Transcriptional regulator
CP977_RS14255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CP977_RS14275	COG1280	lysine exporter protein (LysE YggA)
CP977_RS14290	COG1122	ATPase activity
CP977_RS14300	COG0310	cobalt ion transport
CP977_RS14310	COG2409	Drug exporters of the RND superfamily
CP977_RS14320	COG4946	Tricorn protease homolog
CP977_RS14320	COG0793	Belongs to the peptidase S41A family
CP977_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS14340	COG2267	carboxylic ester hydrolase activity
CP977_RS14345	COG2072	flavoprotein involved in K transport
CP977_RS14385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP977_RS14390	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP977_RS14395	COG0315	cyclic pyranopterin monophosphate synthase activity
CP977_RS14405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP977_RS14410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP977_RS14420	COG3263	regulation of cellular component size
CP977_RS14440	COG1970	mechanosensitive ion channel activity
CP977_RS14465	COG0243	molybdopterin cofactor binding
CP977_RS14490	COG0477	Major facilitator Superfamily
CP977_RS14505	COG3384	dioxygenase
CP977_RS14510	COG1846	Transcriptional regulator
CP977_RS14550	COG4555	ABC transporter
CP977_RS14555	COG0367	asparagine synthase
CP977_RS14600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP977_RS14630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP977_RS14690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS14705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP977_RS14845	COG4695	Portal protein
CP977_RS14920	COG1061	Type III restriction enzyme res subunit
CP977_RS14955	COG1487	ribonuclease activity
CP977_RS14990	COG1686	Belongs to the peptidase S11 family
CP977_RS15015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP977_RS15080	COG1309	transcriptional regulator
CP977_RS15085	COG0259	pyridoxamine-phosphate oxidase activity
CP977_RS15095	COG1309	transcriptional regulator
CP977_RS15100	COG1301	dicarboxylic acid transport
CP977_RS15115	COG2207	Transcriptional regulator
CP977_RS15115	COG3708	Transcriptional regulator
CP977_RS15120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP977_RS15130	COG0163	prenyltransferase activity
CP977_RS15140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CP977_RS15195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP977_RS15200	COG1333	cytochrome c biogenesis protein
CP977_RS15205	COG0785	Cytochrome C biogenesis protein
CP977_RS15220	COG0406	alpha-ribazole phosphatase activity
CP977_RS15225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CP977_RS15240	COG0789	Transcriptional regulator
CP977_RS15285	COG1690	Belongs to the RtcB family
CP977_RS15305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP977_RS15310	COG0018	arginyl-trna synthetase
CP977_RS15330	COG0113	porphobilinogen synthase activity
CP977_RS15335	COG1648	precorrin-2 dehydrogenase activity
CP977_RS15335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP977_RS15340	COG0181	hydroxymethylbilane synthase activity
CP977_RS15345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CP977_RS15350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CP977_RS15400	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP977_RS15410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP977_RS15440	COG1335	isochorismatase
CP977_RS15445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP977_RS15455	COG1131	(ABC) transporter
CP977_RS15470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS15470	COG0515	serine threonine protein kinase
CP977_RS15475	COG0129	dihydroxy-acid dehydratase activity
CP977_RS15485	COG1082	Xylose isomerase domain protein TIM barrel
CP977_RS15490	COG0248	Ppx GppA phosphatase
CP977_RS15510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CP977_RS15525	COG1194	a g-specific adenine glycosylase
CP977_RS15530	COG1595	DNA-templated transcription, initiation
CP977_RS15540	COG0745	RESPONSE REGULATOR receiver
CP977_RS15545	COG2205	protein histidine kinase activity
CP977_RS15560	COG0739	heme binding
CP977_RS15590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CP977_RS15610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP977_RS15620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP977_RS15625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP977_RS15635	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CP977_RS15650	COG2197	response regulator
CP977_RS15665	COG0649	NAD binding
CP977_RS15680	COG1732	Glycine betaine
CP977_RS15690	COG1174	glycine betaine transport
CP977_RS15705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CP977_RS15705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CP977_RS15720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CP977_RS15725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CP977_RS15735	COG0302	gtp cyclohydrolase
CP977_RS15750	COG0037	tRNA processing
CP977_RS15760	COG2027	D-alanyl-D-alanine carboxypeptidase
CP977_RS15765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP977_RS15775	COG0586	Pfam SNARE associated Golgi protein
CP977_RS15780	COG0393	Putative heavy-metal-binding
CP977_RS15805	COG2318	DinB family
CP977_RS15810	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS15830	COG1289	transmembrane transporter activity
CP977_RS15845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP977_RS15845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP977_RS15855	COG1595	DNA-templated transcription, initiation
CP977_RS15910	COG0367	asparagine synthase
CP977_RS15935	COG0252	asparaginase activity
CP977_RS15985	COG3629	intracellular signal transduction
CP977_RS15995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP977_RS16015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP977_RS16030	COG2197	response regulator
CP977_RS16035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP977_RS16060	COG0470	DNA polymerase III
CP977_RS16065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP977_RS16070	COG1754	DNA topoisomerase type I activity
CP977_RS16070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP977_RS16080	COG2890	protein-(glutamine-N5) methyltransferase activity
CP977_RS16090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP977_RS16100	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS16105	COG1111	helicase
CP977_RS16105	COG1205	dead DEAH box helicase
CP977_RS16170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP977_RS16175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP977_RS16185	COG2267	carboxylic ester hydrolase activity
CP977_RS16220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS16245	COG0003	Pfam Anion-transporting ATPase
CP977_RS16255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP977_RS16265	COG1408	metallophosphoesterase
CP977_RS16280	COG0515	serine threonine protein kinase
CP977_RS16280	COG2815	serine threonine protein kinase
CP977_RS16290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CP977_RS16335	COG1595	DNA-templated transcription, initiation
CP977_RS16350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP977_RS16355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP977_RS16370	COG1802	Transcriptional regulator
CP977_RS16380	COG0693	protein deglycase activity
CP977_RS16415	COG1660	Displays ATPase and GTPase activities
CP977_RS16420	COG0604	alcohol dehydrogenase
CP977_RS16425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP977_RS16435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP977_RS16445	COG1247	-acetyltransferase
CP977_RS16450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP977_RS16460	COG0640	Transcriptional regulator
CP977_RS16470	COG2124	cytochrome p450
CP977_RS16475	COG2197	response regulator
CP977_RS16480	COG4585	Histidine kinase
CP977_RS16490	COG3844	kynureninase activity
CP977_RS16510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CP977_RS16515	COG0191	fructose-bisphosphate aldolase activity
CP977_RS16520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP977_RS16540	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CP977_RS16570	COG0542	response to heat
CP977_RS16600	COG0789	Transcriptional regulator
CP977_RS16605	COG0484	heat shock protein binding
CP977_RS16610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP977_RS16615	COG0443	Heat shock 70 kDa protein
CP977_RS16625	COG0247	lactate metabolic process
CP977_RS16625	COG2181	nitrate reductase activity
CP977_RS16640	COG0717	Belongs to the dCTP deaminase family
CP977_RS16650	COG1720	tRNA m6t6A37 methyltransferase activity
CP977_RS16765	COG0596	Alpha beta hydrolase
CP977_RS16765	COG2945	thiolester hydrolase activity
CP977_RS16815	COG0076	glutamate decarboxylase activity
CP977_RS16820	COG2226	methyltransferase
CP977_RS16825	COG1278	Cold shock
CP977_RS16830	COG0513	Belongs to the DEAD box helicase family
CP977_RS16865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP977_RS16905	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CP977_RS16920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS16925	COG0431	NADPH-dependent FMN reductase
CP977_RS16960	COG0596	Alpha beta hydrolase
CP977_RS16990	COG1289	transmembrane transporter activity
CP977_RS17015	COG2205	protein histidine kinase activity
CP977_RS17020	COG0745	RESPONSE REGULATOR receiver
CP977_RS17025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP977_RS17105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP977_RS17120	COG1741	Belongs to the pirin family
CP977_RS17130	COG1960	acyl-CoA dehydrogenase activity
CP977_RS17135	COG1362	aminopeptidase activity
CP977_RS17165	COG0626	cystathionine gamma-synthase activity
CP977_RS17170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP977_RS17185	COG2271	Major facilitator Superfamily
CP977_RS17195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP977_RS17200	COG0022	dehydrogenase e1 component
CP977_RS17225	COG0515	serine threonine protein kinase
CP977_RS17230	COG0515	serine threonine protein kinase
CP977_RS17245	COG4591	ABC-type transport system involved in lipoprotein release permease component
CP977_RS17245	COG1136	(ABC) transporter
CP977_RS17265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP977_RS17280	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP977_RS17295	COG1522	sequence-specific DNA binding
CP977_RS17300	COG1309	transcriptional regulator
CP977_RS17305	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS17330	COG3396	Phenylacetate-CoA oxygenase
CP977_RS17335	COG3460	Phenylacetate-CoA oxygenase
CP977_RS17340	COG3396	Phenylacetate-CoA oxygenase
CP977_RS17345	COG2151	metal-sulfur cluster biosynthetic enzyme
CP977_RS17350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP977_RS17355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP977_RS17380	COG2197	response regulator
CP977_RS17395	COG1716	ATPase activity
CP977_RS17400	COG1716	ATPase activity
CP977_RS17415	COG0768	penicillin binding
CP977_RS17425	COG0515	serine threonine protein kinase
CP977_RS17430	COG3764	Sortase (surface protein transpeptidase)
CP977_RS17435	COG3764	Sortase (surface protein transpeptidase)
CP977_RS17455	COG0705	Rhomboid family
CP977_RS17490	COG0515	serine threonine protein kinase
CP977_RS17515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP977_RS17525	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CP977_RS17530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP977_RS17535	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CP977_RS17540	COG0592	DNA-directed DNA polymerase activity
CP977_RS17565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CP977_RS17570	COG0706	membrane insertase activity
CP977_RS17580	COG0357	Ribosomal RNA small subunit methyltransferase G
CP977_RS17585	COG1192	Involved in chromosome partitioning
CP977_RS17600	COG3118	belongs to the thioredoxin family
CP977_RS17605	COG0492	ferredoxin-NADP+ reductase activity
CP977_RS17615	COG1595	DNA-templated transcription, initiation
CP977_RS17620	COG0515	serine threonine protein kinase
CP977_RS17620	COG2815	serine threonine protein kinase
CP977_RS17635	COG0617	tRNA 3'-terminal CCA addition
CP977_RS17645	COG1260	myo-inositol-1-phosphate synthase
CP977_RS17655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP977_RS17670	COG2348	transferase activity, transferring amino-acyl groups
CP977_RS17680	COG0360	Binds together with S18 to 16S ribosomal RNA
CP977_RS17685	COG0629	single-stranded DNA binding
CP977_RS17690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP977_RS17695	COG0359	binds to the 23S rRNA
CP977_RS17700	COG0534	Mate efflux family protein
CP977_RS17705	COG0305	Participates in initiation and elongation during chromosome replication
CP977_RS17745	COG0626	cystathionine gamma-synthase activity
CP977_RS17750	COG1950	PFAM Membrane protein of
CP977_RS17755	COG0662	Cupin 2, conserved barrel domain protein
CP977_RS17780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP977_RS17790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP977_RS17795	COG1609	Transcriptional regulator
CP977_RS17800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP977_RS17805	COG1271	oxidase subunit
CP977_RS17810	COG1294	oxidase, subunit
CP977_RS17815	COG4988	ABC transporter
CP977_RS17825	COG0561	phosphatase activity
CP977_RS17845	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CP977_RS17850	COG0789	Transcriptional regulator
CP977_RS17865	COG1131	(ABC) transporter
CP977_RS17885	COG2807	transmembrane transport
CP977_RS17890	COG2186	Transcriptional regulator
CP977_RS17900	COG0561	phosphatase activity
CP977_RS17905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP977_RS17915	COG2837	iron assimilation
CP977_RS17930	COG1999	signal sequence binding
CP977_RS17950	COG0006	proline dipeptidase activity
CP977_RS17970	COG0653	protein targeting
CP977_RS17985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP977_RS18000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CP977_RS18010	COG1595	DNA-templated transcription, initiation
CP977_RS18015	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS18020	COG0784	Response regulator, receiver
CP977_RS18070	COG0745	RESPONSE REGULATOR receiver
CP977_RS18075	COG2205	protein histidine kinase activity
CP977_RS18080	COG0463	Glycosyl transferase, family 2
CP977_RS18085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CP977_RS18090	COG0477	Major facilitator Superfamily
CP977_RS18100	COG0477	Major facilitator Superfamily
CP977_RS18115	COG1191	sigma factor activity
CP977_RS18120	COG1191	sigma factor activity
CP977_RS18150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CP977_RS18170	COG2267	carboxylic ester hydrolase activity
CP977_RS18185	COG0655	NAD(P)H dehydrogenase (quinone) activity
CP977_RS18190	COG1937	Protein conserved in bacteria
CP977_RS18205	COG2095	MarC family integral membrane protein
CP977_RS18225	COG1136	(ABC) transporter
CP977_RS18260	COG0419	ATPase involved in DNA repair
CP977_RS18350	COG0151	Belongs to the GarS family
CP977_RS18365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP977_RS18375	COG2197	response regulator
CP977_RS18410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP977_RS18415	COG0047	phosphoribosylformylglycinamidine synthase activity
CP977_RS18420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP977_RS18450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP977_RS18460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP977_RS18485	COG1643	Atp-dependent helicase
CP977_RS18495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CP977_RS18495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP977_RS18500	COG0785	Cytochrome C biogenesis protein
CP977_RS18530	COG0513	Belongs to the DEAD box helicase family
CP977_RS18540	COG2197	response regulator
CP977_RS18545	COG4585	Histidine kinase
CP977_RS18570	COG1597	lipid kinase activity
CP977_RS18595	COG0789	Transcriptional regulator
CP977_RS18610	COG0667	Aldo Keto reductase
CP977_RS18620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP977_RS18625	COG0579	oxidoreductase
CP977_RS18655	COG1252	NADH dehydrogenase
CP977_RS18670	COG1846	Transcriptional regulator
CP977_RS18705	COG1846	Transcriptional regulator
CP977_RS18740	COG0741	lytic transglycosylase activity
CP977_RS18740	COG1196	nuclear chromosome segregation
CP977_RS18740	COG0739	heme binding
CP977_RS18745	COG0671	phosphoesterase, PA-phosphatase related
CP977_RS18760	COG1937	Protein conserved in bacteria
CP977_RS18770	COG0306	phosphate transporter
CP977_RS18775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP977_RS18790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CP977_RS18795	COG0406	alpha-ribazole phosphatase activity
CP977_RS18795	COG0494	nUDIX hydrolase
CP977_RS18820	COG1725	Transcriptional regulator
CP977_RS18825	COG0456	acetyltransferase
CP977_RS18830	COG0737	Belongs to the 5'-nucleotidase family
CP977_RS18835	COG0823	Involved in the tonB-independent uptake of proteins
CP977_RS18850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP977_RS18855	COG1609	Transcriptional regulator
CP977_RS18860	COG0745	RESPONSE REGULATOR receiver
CP977_RS18880	COG2897	thiosulfate sulfurtransferase activity
CP977_RS18910	COG3485	protocatechuate 3,4-dioxygenase
CP977_RS18940	COG1490	D-aminoacyl-tRNA deacylase activity
CP977_RS18950	COG4552	Acetyltransferase involved in intracellular survival and related
CP977_RS19005	COG2249	NAD(P)H dehydrogenase (quinone) activity
CP977_RS19040	COG0438	transferase activity, transferring glycosyl groups
CP977_RS19050	COG2207	Transcriptional regulator
CP977_RS19055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CP977_RS19065	COG0588	phosphoglycerate mutase activity
CP977_RS19085	COG2814	Major facilitator Superfamily
CP977_RS19100	COG5002	protein histidine kinase activity
CP977_RS19120	COG1329	Transcriptional regulator
CP977_RS19125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP977_RS19130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP977_RS19135	COG0215	cysteine-tRNA ligase activity
CP977_RS19140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP977_RS19150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP977_RS19160	COG3842	ATPase activity
CP977_RS19185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS19230	COG2197	response regulator
CP977_RS19260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CP977_RS19325	COG0463	Glycosyl transferase, family 2
CP977_RS19365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP977_RS19365	COG1263	PTS System
CP977_RS19370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CP977_RS19375	COG1737	Transcriptional regulator
CP977_RS19485	COG3142	Participates in the control of copper homeostasis
CP977_RS19505	COG3973	AAA domain
CP977_RS19520	COG1061	Type III restriction enzyme res subunit
CP977_RS19550	COG1278	Cold shock
CP977_RS19555	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP977_RS19560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP977_RS19570	COG2814	Major facilitator Superfamily
CP977_RS19615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CP977_RS19625	COG2252	PERMEase
CP977_RS19655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CP977_RS19660	COG0667	Aldo Keto reductase
CP977_RS19725	COG2267	carboxylic ester hydrolase activity
CP977_RS19750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP977_RS19755	COG0277	FAD linked oxidase domain protein
CP977_RS19760	COG0583	DNA-binding transcription factor activity
CP977_RS19815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP977_RS19850	COG0659	secondary active sulfate transmembrane transporter activity
CP977_RS19855	COG0789	Transcriptional regulator
CP977_RS19860	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS19885	COG0259	pyridoxamine-phosphate oxidase activity
CP977_RS19900	COG4585	Histidine kinase
CP977_RS19905	COG2197	response regulator
CP977_RS19935	COG1733	regulation of RNA biosynthetic process
CP977_RS19945	COG4821	SIS domain
CP977_RS19960	COG0596	Alpha beta hydrolase
CP977_RS19960	COG2945	thiolester hydrolase activity
CP977_RS19995	COG1131	(ABC) transporter
CP977_RS20065	COG1309	transcriptional regulator
CP977_RS20080	COG2072	flavoprotein involved in K transport
CP977_RS20085	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS20085	COG0515	serine threonine protein kinase
CP977_RS20090	COG1309	transcriptional regulator
CP977_RS20100	COG0546	phosphoglycolate phosphatase activity
CP977_RS20130	COG0739	heme binding
CP977_RS20130	COG1196	nuclear chromosome segregation
CP977_RS20130	COG0741	lytic transglycosylase activity
CP977_RS20135	COG1278	Cold shock
CP977_RS20145	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CP977_RS20150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CP977_RS20160	COG2226	methyltransferase
CP977_RS20185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20195	COG0649	NAD binding
CP977_RS20205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP977_RS20210	COG1034	ATP synthesis coupled electron transport
CP977_RS20215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP977_RS20220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20225	COG0839	Belongs to the complex I subunit 6 family
CP977_RS20230	COG0713	ATP synthesis coupled electron transport
CP977_RS20235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CP977_RS20245	COG1007	ATP synthesis coupled electron transport
CP977_RS20260	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP977_RS20275	COG0142	geranyltranstransferase activity
CP977_RS20320	COG0702	epimerase
CP977_RS20325	COG1733	regulation of RNA biosynthetic process
CP977_RS20335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS20335	COG0515	serine threonine protein kinase
CP977_RS20345	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP977_RS20350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP977_RS20350	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP977_RS20370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP977_RS20390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP977_RS20395	COG0839	Belongs to the complex I subunit 6 family
CP977_RS20400	COG0713	ATP synthesis coupled electron transport
CP977_RS20415	COG1007	ATP synthesis coupled electron transport
CP977_RS20420	COG1970	mechanosensitive ion channel activity
CP977_RS20425	COG0501	Belongs to the peptidase M48B family
CP977_RS20430	COG3304	Inner membrane component domain
CP977_RS20440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP977_RS20445	COG1666	GTP binding
CP977_RS20455	COG0702	epimerase
CP977_RS20475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP977_RS20480	COG2030	dehydratase
CP977_RS20490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP977_RS20495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP977_RS20500	COG0436	Aminotransferase
CP977_RS20510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CP977_RS20520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP977_RS20525	COG0081	regulation of translation
CP977_RS20535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP977_RS20540	COG0222	ribosome binding
CP977_RS20550	COG0085	RNA polymerase activity
CP977_RS20555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP977_RS20565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP977_RS20570	COG0049	tRNA binding
CP977_RS20575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP977_RS20580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP977_RS20590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CP977_RS20595	COG0051	transcription antitermination factor activity, RNA binding
CP977_RS20600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP977_RS20605	COG0088	Forms part of the polypeptide exit tunnel
CP977_RS20610	COG0089	rRNA binding
CP977_RS20615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP977_RS20620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP977_RS20625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP977_RS20630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP977_RS20635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP977_RS20640	COG0255	Belongs to the universal ribosomal protein uL29 family
CP977_RS20645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP977_RS20650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP977_RS20655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP977_RS20660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP977_RS20665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP977_RS20675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP977_RS20680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP977_RS20685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP977_RS20690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP977_RS20695	COG1841	ribosomal large subunit assembly
CP977_RS20700	COG0200	Binds to the 23S rRNA
CP977_RS20710	COG0563	adenylate kinase activity
CP977_RS20720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP977_RS20725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP977_RS20730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP977_RS20735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP977_RS20745	COG0203	ribosomal protein L17
CP977_RS20750	COG0101	tRNA pseudouridine synthase activity
CP977_RS20765	COG0488	(ABC) transporter
CP977_RS20770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP977_RS20775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP977_RS20780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP977_RS20790	COG1072	(Pantothenic acid kinase))
CP977_RS20800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP977_RS20805	COG0736	holo-[acyl-carrier-protein] synthase activity
CP977_RS20815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP977_RS20825	COG0802	atpase or kinase
CP977_RS20850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP977_RS20860	COG0726	polysaccharide deacetylase
CP977_RS20870	COG4941	Belongs to the sigma-70 factor family
CP977_RS20885	COG0726	polysaccharide deacetylase
CP977_RS20890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP977_RS20910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP977_RS20915	COG0395	ABC-type sugar transport system, permease component
CP977_RS20920	COG1175	transmembrane transport
CP977_RS20940	COG4221	oxidoreductase activity
CP977_RS20950	COG0583	DNA-binding transcription factor activity
CP977_RS20960	COG2197	response regulator
CP977_RS20965	COG1595	DNA-templated transcription, initiation
CP977_RS20975	COG0516	GMP reductase activity
CP977_RS20985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CP977_RS21000	COG0515	serine threonine protein kinase
CP977_RS21005	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS21025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP977_RS21025	COG0519	Catalyzes the synthesis of GMP from XMP
CP977_RS21055	COG2197	response regulator
CP977_RS21085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP977_RS21105	COG0714	Associated with various cellular activities
CP977_RS21110	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CP977_RS21115	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CP977_RS21120	COG0045	succinate-CoA ligase (ADP-forming) activity
CP977_RS21145	COG0138	bifunctional purine biosynthesis protein purh
CP977_RS21160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP977_RS21175	COG0039	L-malate dehydrogenase activity
CP977_RS21195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP977_RS21200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP977_RS21235	COG0754	glutathionylspermidine amidase activity
CP977_RS21240	COG0726	polysaccharide deacetylase
CP977_RS21245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP977_RS21250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP977_RS21255	COG0180	Tryptophanyl-tRNA synthetase
CP977_RS21275	COG1295	ribonuclease BN
CP977_RS21280	COG1686	Belongs to the peptidase S11 family
CP977_RS21290	COG1408	metallophosphoesterase
CP977_RS21300	COG1309	transcriptional regulator
CP977_RS21315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP977_RS21330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP977_RS21335	COG1053	succinate dehydrogenase
CP977_RS21345	COG2009	succinate dehydrogenase
CP977_RS21355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CP977_RS21380	COG1595	DNA-templated transcription, initiation
CP977_RS21410	COG1216	Glycosyl transferase, family 2
CP977_RS21420	COG1083	cytidylyl-transferase
CP977_RS21425	COG2089	acid synthase
CP977_RS21435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP977_RS21435	COG1473	amidohydrolase
CP977_RS21440	COG1744	ABC transporter substrate-binding protein PnrA-like
CP977_RS21445	COG3845	ABC transporter
CP977_RS21450	COG4603	Belongs to the binding-protein-dependent transport system permease family
CP977_RS21455	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP977_RS21475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP977_RS21495	COG2814	Major facilitator Superfamily
CP977_RS21500	COG0583	DNA-binding transcription factor activity
CP977_RS21510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP977_RS21535	COG2205	protein histidine kinase activity
CP977_RS21540	COG0745	RESPONSE REGULATOR receiver
CP977_RS21545	COG1595	DNA-templated transcription, initiation
CP977_RS21560	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS21565	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS21590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP977_RS21610	COG1349	DNA-binding transcription factor activity
CP977_RS21620	COG4770	biotin carboxylase activity
CP977_RS21630	COG0424	maF-like protein
CP977_RS21640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP977_RS21655	COG1024	Enoyl-CoA hydratase
CP977_RS21665	COG2986	histidine ammonia-lyase
CP977_RS21680	COG1376	ErfK ybiS ycfS ynhG family protein
CP977_RS21690	COG1064	alcohol dehydrogenase
CP977_RS21705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP977_RS21730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP977_RS21745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS21745	COG0515	serine threonine protein kinase
CP977_RS21750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP977_RS21750	COG0515	serine threonine protein kinase
CP977_RS21755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP977_RS21765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP977_RS21780	COG1331	Highly conserved protein containing a thioredoxin domain
CP977_RS21830	COG0438	transferase activity, transferring glycosyl groups
CP977_RS21850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP977_RS21855	COG0438	transferase activity, transferring glycosyl groups
CP977_RS21930	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CP977_RS21970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CP977_RS21985	COG1414	Transcriptional regulator
CP977_RS21990	COG0251	oxidation-reduction process
CP977_RS22025	COG2894	cell division
CP977_RS22070	COG2885	chlorophyll binding
CP977_RS22075	COG3629	intracellular signal transduction
CP977_RS22075	COG3903	Transcriptional regulator
CP977_RS22110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CP977_RS22115	COG0667	Aldo Keto reductase
CP977_RS22120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP977_RS22125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CP977_RS22145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP977_RS22150	COG0450	alkyl hydroperoxide reductase
CP977_RS22165	COG1136	(ABC) transporter
CP977_RS22175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP977_RS22190	COG0114	fumarate hydratase activity
CP977_RS22210	COG0346	lactoylglutathione lyase activity
CP977_RS22230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CP977_RS22230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CP977_RS22255	COG0778	Nitroreductase
CP977_RS22260	COG1722	exodeoxyribonuclease VII activity
CP977_RS22265	COG1570	exodeoxyribonuclease VII activity
CP977_RS22275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP977_RS22290	COG0012	GTP binding
CP977_RS22295	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CP977_RS22305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP977_RS22310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP977_RS22335	COG0582	viral genome integration into host DNA
CP977_RS22345	COG1116	anion transmembrane transporter activity
CP977_RS22350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CP977_RS22360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP977_RS22365	COG0582	viral genome integration into host DNA
CP977_RS22380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP977_RS22390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CP977_RS22405	COG3629	intracellular signal transduction
CP977_RS22405	COG3903	Transcriptional regulator
CP977_RS22460	COG1842	Phage shock protein A
CP977_RS22475	COG1217	gtp-binding protein TYPA
CP977_RS22490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS22500	COG4608	Belongs to the ABC transporter superfamily
CP977_RS22510	COG0601	transmembrane transport
CP977_RS22515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS22520	COG0444	Belongs to the ABC transporter superfamily
CP977_RS22545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP977_RS22600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP977_RS22605	COG1611	Belongs to the LOG family
CP977_RS22610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP977_RS22620	COG0519	Catalyzes the synthesis of GMP from XMP
CP977_RS22625	COG1024	Enoyl-CoA hydratase
CP977_RS22640	COG1595	DNA-templated transcription, initiation
CP977_RS22650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CP977_RS22655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP977_RS22690	COG0598	Magnesium transport protein CorA
CP977_RS22720	COG2095	MarC family integral membrane protein
CP977_RS22730	COG1432	Conserved Protein
CP977_RS22735	COG0596	Alpha beta hydrolase
CP977_RS22740	COG0513	Belongs to the DEAD box helicase family
CP977_RS22785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS22790	COG0601	transmembrane transport
CP977_RS22830	COG2814	Major facilitator Superfamily
CP977_RS22835	COG0477	Major facilitator Superfamily
CP977_RS22885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP977_RS22925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP977_RS22980	COG3480	Lon protease (S16) C-terminal proteolytic domain
CP977_RS22990	COG1615	UPF0182 protein
CP977_RS23015	COG0753	catalase activity
CP977_RS23025	COG0483	inositol monophosphate 1-phosphatase activity
CP977_RS23035	COG2076	Multidrug Resistance protein
CP977_RS23045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP977_RS23055	COG2135	peptidase activity
CP977_RS23065	COG1595	DNA-templated transcription, initiation
CP977_RS23070	COG5662	AntiSigma factor
CP977_RS23090	COG0242	peptide deformylase activity
CP977_RS23100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP977_RS23130	COG0667	Aldo Keto reductase
CP977_RS23145	COG1216	Glycosyl transferase, family 2
CP977_RS23145	COG1442	glycosyl transferase family 8
CP977_RS23150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP977_RS23155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP977_RS23170	COG1215	transferase activity, transferring glycosyl groups
CP977_RS23185	COG2188	Transcriptional regulator
CP977_RS23190	COG2182	Extracellular solute-binding protein
CP977_RS23195	COG1175	transmembrane transport
CP977_RS23200	COG0395	ABC-type sugar transport system, permease component
CP977_RS23205	COG1472	Belongs to the glycosyl hydrolase 3 family
CP977_RS23210	COG0363	glucosamine-6-phosphate deaminase activity
CP977_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS23235	COG1597	lipid kinase activity
CP977_RS23265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CP977_RS23275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP977_RS23280	COG0142	geranyltranstransferase activity
CP977_RS23300	COG5640	endopeptidase activity
CP977_RS23335	COG4106	trans-aconitate 2-methyltransferase activity
CP977_RS23340	COG1126	abc transporter atp-binding protein
CP977_RS23345	COG0765	amino acid transport
CP977_RS23360	COG0604	alcohol dehydrogenase
CP977_RS23400	COG2255	four-way junction helicase activity
CP977_RS23425	COG0567	Dehydrogenase, E1 component
CP977_RS23425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP977_RS23430	COG2205	protein histidine kinase activity
CP977_RS23435	COG0745	RESPONSE REGULATOR receiver
CP977_RS23465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CP977_RS23545	COG0789	Transcriptional regulator
CP977_RS23555	COG0768	penicillin binding
CP977_RS23560	COG0772	Belongs to the SEDS family
CP977_RS23565	COG2205	protein histidine kinase activity
CP977_RS23580	COG3467	pyridoxamine 5'-phosphate
CP977_RS23615	COG0019	diaminopimelate decarboxylase activity
CP977_RS23620	COG0460	homoserine dehydrogenase
CP977_RS23625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CP977_RS23630	COG0083	homoserine kinase activity
CP977_RS23640	COG1316	TRANSCRIPTIONal
CP977_RS23645	COG0254	rRNA binding
CP977_RS23650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP977_RS23655	COG2890	protein-(glutamine-N5) methyltransferase activity
CP977_RS23665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP977_RS23670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP977_RS23690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP977_RS23695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP977_RS23700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP977_RS23705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP977_RS23710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP977_RS23715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP977_RS23720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP977_RS23735	COG2197	response regulator
CP977_RS23740	COG4585	Histidine kinase
CP977_RS23755	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS23770	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CP977_RS23825	COG0183	Belongs to the thiolase family
CP977_RS23885	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP977_RS23885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP977_RS23930	COG0280	phosphate acetyltransferase
CP977_RS23930	COG0857	belongs to the CobB CobQ family
CP977_RS23935	COG0205	6-phosphofructokinase activity
CP977_RS23955	COG4565	transcriptional regulatory protein
CP977_RS23965	COG1301	dicarboxylic acid transport
CP977_RS23970	COG0667	Aldo Keto reductase
CP977_RS23980	COG1522	sequence-specific DNA binding
CP977_RS23985	COG0789	Transcriptional regulator
CP977_RS24005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CP977_RS24015	COG0366	Alpha amylase catalytic
CP977_RS24020	COG0366	Alpha amylase catalytic
CP977_RS24025	COG0058	SHG alpha-glucan phosphorylase activity
CP977_RS24035	COG4585	Histidine kinase
CP977_RS24040	COG2197	response regulator
CP977_RS24050	COG1132	(ABC) transporter
CP977_RS24055	COG1132	(ABC) transporter
CP977_RS24060	COG1131	(ABC) transporter
CP977_RS24070	COG4585	Histidine kinase
CP977_RS24075	COG2197	response regulator
CP977_RS24085	COG1376	ErfK ybiS ycfS ynhG family protein
CP977_RS24125	COG1760	l-serine dehydratase
CP977_RS24130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP977_RS24135	COG0509	glycine decarboxylation via glycine cleavage system
CP977_RS24140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP977_RS24160	COG0747	negative chemotaxis
CP977_RS24165	COG0601	transmembrane transport
CP977_RS24170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS24175	COG0444	Belongs to the ABC transporter superfamily
CP977_RS24180	COG4608	Belongs to the ABC transporter superfamily
CP977_RS24185	COG2860	membrane
CP977_RS24205	COG0482	sulfurtransferase activity
CP977_RS24220	COG4221	oxidoreductase activity
CP977_RS24230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP977_RS24240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP977_RS24245	COG0154	amidase activity
CP977_RS24255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP977_RS24290	COG2409	Drug exporters of the RND superfamily
CP977_RS24295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP977_RS24310	COG2197	response regulator
CP977_RS24320	COG2133	pyrroloquinoline quinone binding
CP977_RS24325	COG0667	Aldo Keto reductase
CP977_RS24345	COG0440	acetolactate synthase activity
CP977_RS24350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP977_RS24355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP977_RS24380	COG1116	anion transmembrane transporter activity
CP977_RS24395	COG0667	Aldo Keto reductase
CP977_RS24400	COG3835	regulator
CP977_RS24405	COG0506	proline dehydrogenase activity
CP977_RS24410	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS24430	COG1695	Transcriptional regulator
CP977_RS24435	COG0473	3-isopropylmalate dehydrogenase activity
CP977_RS24440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP977_RS24450	COG0832	Belongs to the urease beta subunit family
CP977_RS24450	COG0831	urea catabolic process
CP977_RS24455	COG0804	urea catabolic process
CP977_RS24460	COG2957	Belongs to the agmatine deiminase family
CP977_RS24475	COG0477	Major facilitator Superfamily
CP977_RS24485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP977_RS24495	COG0592	DNA-directed DNA polymerase activity
CP977_RS24505	COG2353	YceI-like domain
CP977_RS24515	COG1470	cell adhesion involved in biofilm formation
CP977_RS24515	COG0366	Alpha amylase catalytic
CP977_RS24520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP977_RS24540	COG2018	Roadblock/LC7 domain
CP977_RS24560	COG2018	Roadblock/LC7 domain
CP977_RS24565	COG5002	protein histidine kinase activity
CP977_RS24575	COG0179	Fumarylacetoacetate (FAA) hydrolase
CP977_RS24580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP977_RS24625	COG1414	Transcriptional regulator
CP977_RS24630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP977_RS24635	COG0066	3-isopropylmalate dehydratase activity
CP977_RS24645	COG0776	regulation of translation
CP977_RS24655	COG1920	GTP binding
CP977_RS24665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP977_RS24670	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP977_RS24690	COG0351	phosphomethylpyrimidine kinase
CP977_RS24695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP977_RS24700	COG1461	Dihydroxyacetone kinase
CP977_RS24705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CP977_RS24710	COG0742	ribosomal rna small subunit methyltransferase
CP977_RS24715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP977_RS24730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP977_RS24735	COG0571	ribonuclease III activity
CP977_RS24740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP977_RS24755	COG0546	phosphoglycolate phosphatase activity
CP977_RS24830	COG1254	Belongs to the acylphosphatase family
CP977_RS24840	COG1196	nuclear chromosome segregation
CP977_RS24845	COG0477	Major facilitator Superfamily
CP977_RS24875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP977_RS24885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP977_RS24900	COG0228	four-way junction DNA binding
CP977_RS24905	COG1837	Belongs to the UPF0109 family
CP977_RS24910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP977_RS24915	COG0336	Belongs to the RNA methyltransferase TrmD family
CP977_RS24920	COG0335	large ribosomal subunit rRNA binding
CP977_RS24935	COG0681	Belongs to the peptidase S26 family
CP977_RS24940	COG0681	Belongs to the peptidase S26 family
CP977_RS24955	COG0792	nuclease activity
CP977_RS24970	COG1191	sigma factor activity
CP977_RS24990	COG0052	Belongs to the universal ribosomal protein uS2 family
CP977_RS24995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP977_RS25000	COG0528	UMP kinase activity
CP977_RS25005	COG0233	cytoplasmic translational termination
CP977_RS25010	COG0575	Belongs to the CDS family
CP977_RS25015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP977_RS25025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CP977_RS25030	COG3842	ATPase activity
CP977_RS25050	COG1136	(ABC) transporter
CP977_RS25055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP977_RS25065	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS25090	COG2197	response regulator
CP977_RS25095	COG4585	Histidine kinase
CP977_RS25105	COG0584	glycerophosphoryl diester phosphodiesterase
CP977_RS25110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP977_RS25135	COG3842	ATPase activity
CP977_RS25140	COG1176	ABC-type spermidine putrescine transport system, permease component I
CP977_RS25150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS25180	COG2508	Transcriptional regulator
CP977_RS25190	COG0697	spore germination
CP977_RS25195	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS25200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP977_RS25205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP977_RS25210	COG0750	zinc metalloprotease
CP977_RS25215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP977_RS25230	COG0442	prolyl-tRNA aminoacylation
CP977_RS25235	COG0330	HflC and HflK could
CP977_RS25255	COG0779	Required for maturation of 30S ribosomal subunits
CP977_RS25270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP977_RS25280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP977_RS25285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP977_RS25300	COG4608	Belongs to the ABC transporter superfamily
CP977_RS25305	COG0444	Belongs to the ABC transporter superfamily
CP977_RS25315	COG0601	transmembrane transport
CP977_RS25320	COG4166	transmembrane transport
CP977_RS25325	COG0455	bacterial-type flagellum organization
CP977_RS25345	COG3266	domain, Protein
CP977_RS25350	COG1404	Belongs to the peptidase S8 family
CP977_RS25360	COG1404	Belongs to the peptidase S8 family
CP977_RS25410	COG1674	ftsk spoiiie
CP977_RS25420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP977_RS25425	COG1185	polyribonucleotide nucleotidyltransferase activity
CP977_RS25430	COG0612	Peptidase, M16
CP977_RS25435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP977_RS25455	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CP977_RS25460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP977_RS25465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CP977_RS25495	COG2770	Histidine kinase
CP977_RS25495	COG2208	phosphoserine phosphatase activity
CP977_RS25500	COG2205	protein histidine kinase activity
CP977_RS25500	COG3850	Histidine kinase
CP977_RS25500	COG4999	Histidine kinase
CP977_RS25500	COG3437	response regulator, receiver
CP977_RS25510	COG1674	ftsk spoiiie
CP977_RS25520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP977_RS25530	COG1058	Belongs to the CinA family
CP977_RS25530	COG1546	Belongs to the CinA family
CP977_RS25535	COG1396	sequence-specific DNA binding
CP977_RS25540	COG0783	Belongs to the Dps family
CP977_RS25550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP977_RS25555	COG1201	RNA secondary structure unwinding
CP977_RS25560	COG2207	Transcriptional regulator
CP977_RS25560	COG1917	Cupin 2, conserved barrel domain protein
CP977_RS25595	COG1271	oxidase subunit
CP977_RS25600	COG2197	response regulator
CP977_RS25605	COG4585	Histidine kinase
CP977_RS25615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP977_RS25625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CP977_RS25635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP977_RS25640	COG0765	amino acid transport
CP977_RS25645	COG0765	amino acid transport
CP977_RS25650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS25655	COG1126	abc transporter atp-binding protein
CP977_RS25660	COG0745	RESPONSE REGULATOR receiver
CP977_RS25665	COG2205	protein histidine kinase activity
CP977_RS25670	COG2358	TRAP transporter, solute receptor (TAXI family
CP977_RS25675	COG2197	response regulator
CP977_RS25680	COG4585	Histidine kinase
CP977_RS25685	COG0586	Pfam SNARE associated Golgi protein
CP977_RS25695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP977_RS25710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP977_RS25720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP977_RS25725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP977_RS25735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP977_RS25780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP977_RS25785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP977_RS25790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP977_RS25815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP977_RS25835	COG1793	dna ligase
CP977_RS25860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CP977_RS25865	COG1802	Transcriptional regulator
CP977_RS25870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP977_RS25885	COG0187	DNA topoisomerase II activity
CP977_RS25895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP977_RS25900	COG4565	transcriptional regulatory protein
CP977_RS25905	COG3290	protein histidine kinase activity
CP977_RS25915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP977_RS25920	COG0612	Peptidase, M16
CP977_RS25935	COG1802	Transcriptional regulator
CP977_RS25940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP977_RS25950	COG1042	CoA-binding domain protein
CP977_RS25950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP977_RS25950	COG0045	succinate-CoA ligase (ADP-forming) activity
CP977_RS25965	COG1435	thymidine kinase activity
CP977_RS26035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP977_RS26045	COG0745	RESPONSE REGULATOR receiver
CP977_RS26050	COG2205	protein histidine kinase activity
CP977_RS26075	COG0756	dUTP diphosphatase activity
CP977_RS26085	COG1136	(ABC) transporter
CP977_RS26085	COG4591	ABC-type transport system involved in lipoprotein release permease component
CP977_RS26115	COG0569	domain protein
CP977_RS26120	COG0531	amino acid
CP977_RS26125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP977_RS26155	COG2197	response regulator
CP977_RS26160	COG3851	Histidine kinase
CP977_RS26175	COG2268	Band 7 protein
CP977_RS26210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS26230	COG3938	Belongs to the proline racemase family
CP977_RS26235	COG1802	Transcriptional regulator
CP977_RS26240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CP977_RS26245	COG1799	cell septum assembly
CP977_RS26270	COG2040	homocysteine
CP977_RS26280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP977_RS26290	COG2235	arginine
CP977_RS26295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP977_RS26300	COG0531	amino acid
CP977_RS26305	COG1024	Enoyl-CoA hydratase
CP977_RS26320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CP977_RS26325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS26330	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS26350	COG0673	inositol 2-dehydrogenase activity
CP977_RS26360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP977_RS26385	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS26480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CP977_RS26495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP977_RS26505	COG1653	transport
CP977_RS26510	COG1175	transmembrane transport
CP977_RS26515	COG0395	ABC-type sugar transport system, permease component
CP977_RS26520	COG1940	carbohydrate kinase activity
CP977_RS26525	COG4213	ABC transporter substrate-binding protein
CP977_RS26535	COG4214	carbohydrate transport
CP977_RS26540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP977_RS26545	COG0531	amino acid
CP977_RS26555	COG1316	TRANSCRIPTIONal
CP977_RS26570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CP977_RS26570	COG1215	transferase activity, transferring glycosyl groups
CP977_RS26575	COG2755	lipolytic protein G-D-S-L family
CP977_RS26585	COG5434	Belongs to the glycosyl hydrolase 28 family
CP977_RS26585	COG4632	Exopolysaccharide biosynthesis protein
CP977_RS26590	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS26590	COG1024	Enoyl-CoA hydratase
CP977_RS26595	COG0183	Belongs to the thiolase family
CP977_RS26615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP977_RS26620	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP977_RS26630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP977_RS26635	COG3253	May function as heme-dependent peroxidase
CP977_RS26645	COG3220	belongs to the UPF0276 family
CP977_RS26655	COG1116	anion transmembrane transporter activity
CP977_RS26685	COG2326	polyphosphate kinase activity
CP977_RS26715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP977_RS26720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP977_RS26735	COG1404	Belongs to the peptidase S8 family
CP977_RS26740	COG1733	regulation of RNA biosynthetic process
CP977_RS26745	COG2084	Dehydrogenase
CP977_RS26800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP977_RS26810	COG0346	lactoylglutathione lyase activity
CP977_RS26880	COG0596	Alpha beta hydrolase
CP977_RS26905	COG0142	geranyltranstransferase activity
CP977_RS26925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CP977_RS26940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP977_RS26945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CP977_RS26965	COG0529	Catalyzes the synthesis of activated sulfate
CP977_RS26970	COG0175	sulfate reduction
CP977_RS26995	COG1960	acyl-CoA dehydrogenase activity
CP977_RS27025	COG1162	GTPase activity
CP977_RS27050	COG1404	Belongs to the peptidase S8 family
CP977_RS27060	COG0028	Belongs to the TPP enzyme family
CP977_RS27080	COG1802	Transcriptional regulator
CP977_RS27115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP977_RS27120	COG2252	PERMEase
CP977_RS27155	COG0300	oxidoreductase activity
CP977_RS27160	COG0789	Transcriptional regulator
CP977_RS27195	COG1309	transcriptional regulator
CP977_RS27200	COG1960	acyl-CoA dehydrogenase activity
CP977_RS27295	COG1222	aaa ATPase
CP977_RS27305	COG2197	response regulator
CP977_RS27310	COG2045	Belongs to the ComB family
CP977_RS27330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP977_RS27355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP977_RS27360	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS27380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS27385	COG1120	ATPase activity
CP977_RS27400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS27420	COG0475	glutathione-regulated potassium exporter activity
CP977_RS27445	COG1960	acyl-CoA dehydrogenase activity
CP977_RS27455	COG0300	oxidoreductase activity
CP977_RS27465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS27475	COG0477	Major facilitator Superfamily
CP977_RS27480	COG0583	DNA-binding transcription factor activity
CP977_RS27485	COG0640	Transcriptional regulator
CP977_RS27490	COG0346	lactoylglutathione lyase activity
CP977_RS27515	COG2197	response regulator
CP977_RS27520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP977_RS27525	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS27545	COG3960	tartronate-semialdehyde synthase activity
CP977_RS27560	COG0753	catalase activity
CP977_RS27565	COG2084	Dehydrogenase
CP977_RS27570	COG3622	Belongs to the hyi family
CP977_RS27590	COG2351	hydroxyisourate hydrolase activity
CP977_RS27600	COG2233	PERMEase
CP977_RS27610	COG2233	PERMEase
CP977_RS27625	COG4733	cellulase activity
CP977_RS27625	COG5297	Belongs to the glycosyl hydrolase family 6
CP977_RS27640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP977_RS27655	COG2197	response regulator
CP977_RS27660	COG4585	Histidine kinase
CP977_RS27670	COG1136	(ABC) transporter
CP977_RS27670	COG0577	efflux transmembrane transporter activity
CP977_RS27675	COG1414	Transcriptional regulator
CP977_RS27680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP977_RS27685	COG4266	Belongs to the allantoicase family
CP977_RS27690	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS27695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CP977_RS27715	COG4585	Histidine kinase
CP977_RS27720	COG2197	response regulator
CP977_RS27725	COG0673	inositol 2-dehydrogenase activity
CP977_RS27740	COG1129	ABC transporter
CP977_RS27745	COG1940	carbohydrate kinase activity
CP977_RS27760	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS27770	COG3629	intracellular signal transduction
CP977_RS27770	COG3903	Transcriptional regulator
CP977_RS27795	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS27815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CP977_RS27820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CP977_RS27835	COG1126	abc transporter atp-binding protein
CP977_RS27840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS27845	COG0765	amino acid transport
CP977_RS27850	COG0765	amino acid transport
CP977_RS27870	COG0405	Gamma-glutamyltransferase
CP977_RS27905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP977_RS27925	COG0667	Aldo Keto reductase
CP977_RS27935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP977_RS28005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP977_RS28010	COG0386	Belongs to the glutathione peroxidase family
CP977_RS28040	COG0604	alcohol dehydrogenase
CP977_RS28040	COG3321	synthase
CP977_RS28050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP977_RS28055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP977_RS28105	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CP977_RS28125	COG0483	inositol monophosphate 1-phosphatase activity
CP977_RS28135	COG0009	L-threonylcarbamoyladenylate synthase
CP977_RS28155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP977_RS28160	COG1929	Belongs to the glycerate kinase type-1 family
CP977_RS28180	COG0559	Belongs to the binding-protein-dependent transport system permease family
CP977_RS28195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP977_RS28200	COG0456	acetyltransferase
CP977_RS28210	COG0688	phosphatidylethanolamine metabolic process
CP977_RS28215	COG1960	acyl-CoA dehydrogenase activity
CP977_RS28230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP977_RS28230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP977_RS28235	COG0604	alcohol dehydrogenase
CP977_RS28245	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS28255	COG0596	Alpha beta hydrolase
CP977_RS28280	COG2362	D-Aminopeptidase
CP977_RS28285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP977_RS28290	COG4946	Tricorn protease homolog
CP977_RS28290	COG0823	Involved in the tonB-independent uptake of proteins
CP977_RS28290	COG1506	peptidase
CP977_RS28295	COG1619	proteins homologs of microcin C7 resistance protein MccF
CP977_RS28300	COG1073	alpha beta
CP977_RS28300	COG2226	methyltransferase
CP977_RS28310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CP977_RS28330	COG2226	methyltransferase
CP977_RS28375	COG2318	DinB family
CP977_RS28390	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP977_RS28400	COG0702	epimerase
CP977_RS28415	COG0656	L-ascorbic acid biosynthetic process
CP977_RS28425	COG0583	DNA-binding transcription factor activity
CP977_RS28445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP977_RS28460	COG1940	carbohydrate kinase activity
CP977_RS28460	COG1846	Transcriptional regulator
CP977_RS28465	COG1129	ABC transporter
CP977_RS28470	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP977_RS28480	COG0673	inositol 2-dehydrogenase activity
CP977_RS28525	COG1486	melibiose metabolic process
CP977_RS28530	COG3012	SEC-C Motif Domain Protein
CP977_RS28590	COG0488	(ABC) transporter
CP977_RS28625	COG0702	epimerase
CP977_RS28660	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS28665	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS28695	COG0673	inositol 2-dehydrogenase activity
CP977_RS28710	COG1515	deoxyribonuclease V activity
CP977_RS28720	COG3268	Saccharopine dehydrogenase
CP977_RS28725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS28730	COG1960	acyl-CoA dehydrogenase activity
CP977_RS28735	COG0183	Belongs to the thiolase family
CP977_RS28740	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP977_RS28740	COG1024	Enoyl-CoA hydratase
CP977_RS28765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP977_RS28780	COG2936	dipeptidyl-peptidase activity
CP977_RS28795	COG0488	(ABC) transporter
CP977_RS28825	COG1024	Enoyl-CoA hydratase
CP977_RS28835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CP977_RS28880	COG1134	teichoic acid transport
CP977_RS28880	COG1388	LysM domain
CP977_RS28885	COG1562	ergosterol biosynthetic process
CP977_RS28900	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CP977_RS28910	COG1657	PFAM Prenyltransferase squalene oxidase
CP977_RS28935	COG2365	Tyrosine phosphatase family
CP977_RS28945	COG2755	lipolytic protein G-D-S-L family
CP977_RS28990	COG1309	transcriptional regulator
CP977_RS29030	COG1960	acyl-CoA dehydrogenase activity
CP977_RS29040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CP977_RS29045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CP977_RS29050	COG2080	2 iron, 2 sulfur cluster binding
CP977_RS29075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP977_RS29080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP977_RS29090	COG0438	transferase activity, transferring glycosyl groups
CP977_RS29110	COG3237	CsbD-like
CP977_RS29130	COG1132	(ABC) transporter
CP977_RS29135	COG0514	ATP-dependent DNA helicase (RecQ)
CP977_RS29145	COG0542	response to heat
CP977_RS29150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP977_RS29175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP977_RS29190	COG1404	Belongs to the peptidase S8 family
CP977_RS29285	COG0720	synthase
CP977_RS29300	COG2255	four-way junction helicase activity
CP977_RS29305	COG2188	Transcriptional regulator
CP977_RS29325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CP977_RS29330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CP977_RS29345	COG1595	DNA-templated transcription, initiation
CP977_RS29395	COG0384	phenazine biosynthesis protein PhzF
CP977_RS29400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CP977_RS29405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CP977_RS29460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP977_RS29480	COG3336	cytochrome c oxidase
CP977_RS29495	COG0243	molybdopterin cofactor binding
CP977_RS29500	COG2264	protein methyltransferase activity
CP977_RS29505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP977_RS29510	COG0254	rRNA binding
CP977_RS29520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP977_RS29555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP977_RS29600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CP977_RS29615	COG0584	glycerophosphoryl diester phosphodiesterase
CP977_RS29635	COG0395	ABC-type sugar transport system, permease component
CP977_RS29655	COG5297	Belongs to the glycosyl hydrolase family 6
CP977_RS29660	COG5297	Belongs to the glycosyl hydrolase family 6
CP977_RS29665	COG1595	DNA-templated transcription, initiation
CP977_RS29675	COG0432	Pfam Uncharacterised protein family UPF0047
CP977_RS29680	COG1879	ABC-type sugar transport system periplasmic component
CP977_RS29695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP977_RS29705	COG4214	carbohydrate transport
CP977_RS29710	COG1129	ABC transporter
CP977_RS29720	COG1609	Transcriptional regulator
CP977_RS29730	COG2160	L-arabinose isomerase activity
CP977_RS29745	COG2409	Drug exporters of the RND superfamily
CP977_RS29750	COG4585	Histidine kinase
CP977_RS29755	COG2197	response regulator
CP977_RS29795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP977_RS29825	COG1408	metallophosphoesterase
CP977_RS29930	COG2910	NAD(P)H-binding
CP977_RS29950	COG1309	transcriptional regulator
CP977_RS29995	COG0456	acetyltransferase
CP977_RS30005	COG0515	serine threonine protein kinase
CP977_RS30010	COG0515	serine threonine protein kinase
CP977_RS30010	COG2815	serine threonine protein kinase
CP977_RS30015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP977_RS30095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CP977_RS30095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CP977_RS30100	COG0210	DNA helicase
CP977_RS30135	COG1366	Belongs to the anti-sigma-factor antagonist family
CP977_RS30145	COG0596	Alpha beta hydrolase
CP977_RS30165	COG1231	oxidoreductase activity
CP977_RS30180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP977_RS30210	COG3903	Transcriptional regulator
CP977_RS30210	COG3629	intracellular signal transduction
CP977_RS30225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS30245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS30250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP977_RS30270	COG0017	Asparaginyl-tRNA synthetase
CP977_RS30335	COG1024	Enoyl-CoA hydratase
CP977_RS30350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS30380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS30385	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS30390	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS30400	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS30415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CP977_RS30430	COG0657	acetylesterase activity
CP977_RS30435	COG2072	flavoprotein involved in K transport
CP977_RS30440	COG1607	acyl-coa hydrolase
CP977_RS30445	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CP977_RS30525	COG3275	phosphorelay sensor kinase activity
CP977_RS30595	COG1053	succinate dehydrogenase
CP977_RS30600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CP977_RS30615	COG0477	Major facilitator Superfamily
CP977_RS30640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS30655	COG2182	Extracellular solute-binding protein
CP977_RS30670	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP977_RS30675	COG0121	glutamine amidotransferase
CP977_RS30680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP977_RS30685	COG3572	ergothioneine biosynthetic process
CP977_RS30695	COG0596	Alpha beta hydrolase
CP977_RS30705	COG0183	Belongs to the thiolase family
CP977_RS30710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CP977_RS30715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP977_RS30765	COG1073	alpha beta
CP977_RS30770	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS30795	COG1073	alpha beta
CP977_RS30805	COG1063	alcohol dehydrogenase
CP977_RS30815	COG1073	alpha beta
CP977_RS30820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CP977_RS30830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS30835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS30855	COG1960	acyl-CoA dehydrogenase activity
CP977_RS30860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS30875	COG0477	Major facilitator Superfamily
CP977_RS30885	COG2124	cytochrome p450
CP977_RS30920	COG3284	Transcriptional regulator
CP977_RS30935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP977_RS30945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS30950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS30955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS30960	COG2301	Belongs to the HpcH HpaI aldolase family
CP977_RS30965	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CP977_RS30990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CP977_RS30995	COG2181	nitrate reductase activity
CP977_RS30995	COG0247	lactate metabolic process
CP977_RS31010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP977_RS31015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CP977_RS31020	COG1960	acyl-CoA dehydrogenase activity
CP977_RS31030	COG2301	Belongs to the HpcH HpaI aldolase family
CP977_RS31035	COG0477	Major facilitator Superfamily
CP977_RS31040	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS31065	COG1063	alcohol dehydrogenase
CP977_RS31070	COG1172	Belongs to the binding-protein-dependent transport system permease family
CP977_RS31085	COG1129	ABC transporter
CP977_RS31090	COG0183	Belongs to the thiolase family
CP977_RS31105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP977_RS31130	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS31155	COG1063	alcohol dehydrogenase
CP977_RS31165	COG1073	alpha beta
CP977_RS31170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CP977_RS31185	COG1079	Belongs to the binding-protein-dependent transport system permease family
CP977_RS31190	COG1129	ABC transporter
CP977_RS31230	COG2175	clavaminate synthase activity
CP977_RS31260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP977_RS31270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS31280	COG1482	cell wall glycoprotein biosynthetic process
CP977_RS31285	COG1115	amino acid carrier protein
CP977_RS31290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP977_RS31295	COG1126	abc transporter atp-binding protein
CP977_RS31300	COG0765	amino acid transport
CP977_RS31305	COG0765	amino acid transport
CP977_RS31310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS31335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP977_RS31360	COG0326	Molecular chaperone. Has ATPase activity
CP977_RS31430	COG1191	sigma factor activity
CP977_RS31445	COG0825	malonyl-CoA metabolic process
CP977_RS31445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP977_RS31455	COG1126	abc transporter atp-binding protein
CP977_RS31460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS31465	COG0765	amino acid transport
CP977_RS31470	COG0765	amino acid transport
CP977_RS31480	COG1595	DNA-templated transcription, initiation
CP977_RS31495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CP977_RS31505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP977_RS31515	COG3634	alkyl hydroperoxide reductase activity
CP977_RS31530	COG1960	acyl-CoA dehydrogenase activity
CP977_RS31535	COG1960	acyl-CoA dehydrogenase activity
CP977_RS31545	COG0601	transmembrane transport
CP977_RS31550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CP977_RS31555	COG0444	Belongs to the ABC transporter superfamily
CP977_RS31575	COG1051	belongs to the nudix hydrolase family
CP977_RS31600	COG0493	'glutamate synthase
CP977_RS31600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CP977_RS31615	COG1874	Beta-galactosidase
CP977_RS31615	COG0366	Alpha amylase catalytic
CP977_RS31635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CP977_RS31640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CP977_RS31645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP977_RS31650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP977_RS31660	COG2188	Transcriptional regulator
CP977_RS31685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CP977_RS31695	COG0367	asparagine synthase
CP977_RS31700	COG1982	Orn Lys Arg decarboxylase major
CP977_RS31740	COG0395	ABC-type sugar transport system, permease component
CP977_RS31790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS31795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CP977_RS31800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CP977_RS31845	COG0402	S-adenosylhomocysteine deaminase activity
CP977_RS31850	COG1802	Transcriptional regulator
CP977_RS31860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CP977_RS31870	COG0180	Tryptophanyl-tRNA synthetase
CP977_RS31910	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CP977_RS31940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP977_RS31945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP977_RS31960	COG1595	DNA-templated transcription, initiation
CP977_RS32000	COG1309	transcriptional regulator
CP977_RS32025	COG1309	transcriptional regulator
CP977_RS32030	COG1902	pentaerythritol trinitrate reductase activity
CP977_RS32030	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP977_RS32045	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP977_RS32045	COG1902	pentaerythritol trinitrate reductase activity
CP977_RS32065	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS32070	COG3268	Saccharopine dehydrogenase
CP977_RS32075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP977_RS32090	COG0477	Major facilitator Superfamily
CP977_RS32100	COG1960	acyl-CoA dehydrogenase activity
CP977_RS32105	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS32110	COG0318	PFAM AMP-dependent synthetase and ligase
CP977_RS32130	COG0531	amino acid
CP977_RS32135	COG1012	belongs to the aldehyde dehydrogenase family
CP977_RS32140	COG0583	DNA-binding transcription factor activity
CP977_RS32150	COG2409	Drug exporters of the RND superfamily
CP977_RS32160	COG0385	Bile acid
CP977_RS32240	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CP977_RS32250	COG0473	3-isopropylmalate dehydrogenase activity
CP977_RS32270	COG2208	phosphoserine phosphatase activity
CP977_RS32270	COG2770	Histidine kinase
CP977_RS32280	COG0435	Glutathione S-transferase
CP977_RS32285	COG2267	carboxylic ester hydrolase activity
CP977_RS32295	COG2124	cytochrome p450
CP977_RS32300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP977_RS32315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP977_RS32320	COG3239	Fatty acid desaturase
CP977_RS32330	COG1418	mRNA catabolic process
CP977_RS32380	COG2018	Roadblock/LC7 domain
CP977_RS32400	COG0726	polysaccharide deacetylase
CP977_RS32420	COG1017	nitric oxide dioxygenase activity
CP977_RS32420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP977_RS32425	COG1959	2 iron, 2 sulfur cluster binding
CP977_RS32460	COG1473	amidohydrolase
CP977_RS32470	COG1960	acyl-CoA dehydrogenase activity
CP977_RS32475	COG1309	transcriptional regulator
CP977_RS32490	COG0477	Major facilitator Superfamily
CP977_RS32500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS32505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS32515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP977_RS32540	COG1051	belongs to the nudix hydrolase family
CP977_RS32560	COG0702	epimerase
CP977_RS32565	COG0254	rRNA binding
CP977_RS32590	COG1349	DNA-binding transcription factor activity
CP977_RS32595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP977_RS32615	COG0596	Alpha beta hydrolase
CP977_RS32630	COG4977	sequence-specific DNA binding
CP977_RS32685	COG1191	sigma factor activity
CP977_RS32690	COG0693	protein deglycase activity
CP977_RS32725	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS32755	COG0714	Associated with various cellular activities
CP977_RS32795	COG1335	isochorismatase
CP977_RS32800	COG0589	response to stress
CP977_RS32810	COG3285	dna ligase
CP977_RS32810	COG1793	dna ligase
CP977_RS32820	COG2124	cytochrome p450
CP977_RS32850	COG0723	plastoquinol--plastocyanin reductase activity
CP977_RS32850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS32865	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS32890	COG4941	Belongs to the sigma-70 factor family
CP977_RS32895	COG3795	YCII-related domain
CP977_RS32910	COG1028	Short-chain dehydrogenase reductase Sdr
CP977_RS32915	COG1295	ribonuclease BN
CP977_RS32965	COG4106	trans-aconitate 2-methyltransferase activity
CP977_RS32975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP977_RS32985	COG2124	cytochrome p450
CP977_RS32995	COG2815	serine threonine protein kinase
CP977_RS32995	COG0515	serine threonine protein kinase
CP977_RS33025	COG1472	Belongs to the glycosyl hydrolase 3 family
CP977_RS33050	COG1404	Belongs to the peptidase S8 family
CP977_RS33075	COG0673	inositol 2-dehydrogenase activity
CP977_RS33100	COG0539	negative regulation of cytoplasmic translation
CP977_RS33165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP977_RS33170	COG0366	Alpha amylase catalytic
CP977_RS33220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP977_RS33315	COG1215	transferase activity, transferring glycosyl groups
CP977_RS33320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CP977_RS33325	COG0640	Transcriptional regulator
CP977_RS33365	COG1733	regulation of RNA biosynthetic process
CP977_RS33450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP977_RS33560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP977_RS33590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CP977_RS33680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CP977_RS33680	COG0723	plastoquinol--plastocyanin reductase activity
CP977_RS33730	COG1660	Displays ATPase and GTPase activities
CP977_RS33735	COG0598	Magnesium transport protein CorA
CP977_RS33770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily