locus-tag	class	description
CRV15_RS00015	COG0454	-acetyltransferase
CRV15_RS00020	COG1280	lysine exporter protein (LysE YggA)
CRV15_RS00050	COG1966	Carbon starvation protein
CRV15_RS00080	COG0019	diaminopimelate decarboxylase activity
CRV15_RS00105	COG0475	glutathione-regulated potassium exporter activity
CRV15_RS00105	COG0569	domain protein
CRV15_RS00130	COG2814	Major facilitator Superfamily
CRV15_RS00155	COG1063	alcohol dehydrogenase
CRV15_RS00160	COG0156	8-amino-7-oxononanoate synthase activity
CRV15_RS00170	COG2018	Roadblock/LC7 domain
CRV15_RS00185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CRV15_RS00210	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS00215	COG0531	amino acid
CRV15_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS00240	COG0142	geranyltranstransferase activity
CRV15_RS00260	COG2124	cytochrome p450
CRV15_RS00295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRV15_RS00310	COG1215	transferase activity, transferring glycosyl groups
CRV15_RS00320	COG4310	Domain of unknown function (DUF2172)
CRV15_RS00335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRV15_RS00345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRV15_RS00345	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS00380	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS00385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CRV15_RS00435	COG0473	3-isopropylmalate dehydrogenase activity
CRV15_RS00485	COG1846	Transcriptional regulator
CRV15_RS00500	COG0542	response to heat
CRV15_RS00505	COG1366	Belongs to the anti-sigma-factor antagonist family
CRV15_RS00505	COG2172	sigma factor antagonist activity
CRV15_RS00505	COG2208	phosphoserine phosphatase activity
CRV15_RS00520	COG1653	transport
CRV15_RS00525	COG1233	COG1233 Phytoene dehydrogenase and related
CRV15_RS00550	COG1233	COG1233 Phytoene dehydrogenase and related
CRV15_RS00555	COG2130	NADP-dependent
CRV15_RS00560	COG2376	Dihydroxyacetone kinase
CRV15_RS00565	COG2376	Dihydroxyacetone kinase
CRV15_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS00620	COG2124	cytochrome p450
CRV15_RS00660	COG1124	(ABC) transporter
CRV15_RS00665	COG0444	Belongs to the ABC transporter superfamily
CRV15_RS00670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS00675	COG0601	transmembrane transport
CRV15_RS00685	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS00690	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS00720	COG1125	glycine betaine transport
CRV15_RS00720	COG0517	IMP dehydrogenase activity
CRV15_RS00725	COG3458	cephalosporin-C deacetylase activity
CRV15_RS00740	COG1174	glycine betaine transport
CRV15_RS00745	COG1174	glycine betaine transport
CRV15_RS00755	COG1309	transcriptional regulator
CRV15_RS00780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRV15_RS00795	COG2124	cytochrome p450
CRV15_RS00820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRV15_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRV15_RS00840	COG1024	Enoyl-CoA hydratase
CRV15_RS00865	COG2124	cytochrome p450
CRV15_RS00900	COG0463	Glycosyl transferase, family 2
CRV15_RS00915	COG0402	S-adenosylhomocysteine deaminase activity
CRV15_RS00935	COG1413	lyase activity
CRV15_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS00985	COG2326	polyphosphate kinase activity
CRV15_RS00990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRV15_RS01040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRV15_RS01045	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRV15_RS01050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRV15_RS01100	COG0183	Belongs to the thiolase family
CRV15_RS01125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRV15_RS01130	COG1376	ErfK ybiS ycfS ynhG family protein
CRV15_RS01150	COG0535	radical SAM domain protein
CRV15_RS01160	COG3424	synthase
CRV15_RS01170	COG3959	Transketolase, thiamine diphosphate binding domain
CRV15_RS01205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRV15_RS01210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CRV15_RS01295	COG1131	(ABC) transporter
CRV15_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS01345	COG1309	transcriptional regulator
CRV15_RS01380	COG3629	intracellular signal transduction
CRV15_RS01380	COG3903	Transcriptional regulator
CRV15_RS01385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CRV15_RS01390	COG1597	lipid kinase activity
CRV15_RS01410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRV15_RS01410	COG0574	Belongs to the PEP-utilizing enzyme family
CRV15_RS01450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRV15_RS01455	COG0477	Major facilitator Superfamily
CRV15_RS01475	COG1174	glycine betaine transport
CRV15_RS01480	COG1174	glycine betaine transport
CRV15_RS01515	COG2957	Belongs to the agmatine deiminase family
CRV15_RS01535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRV15_RS01575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CRV15_RS01585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRV15_RS01595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS01610	COG2207	Transcriptional regulator
CRV15_RS01615	COG1120	ATPase activity
CRV15_RS01620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CRV15_RS01635	COG4552	Acetyltransferase involved in intracellular survival and related
CRV15_RS01655	COG2197	response regulator
CRV15_RS01660	COG0154	amidase activity
CRV15_RS01670	COG0477	Major facilitator Superfamily
CRV15_RS01675	COG0579	oxidoreductase
CRV15_RS01695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CRV15_RS01695	COG2755	lipolytic protein G-D-S-L family
CRV15_RS01710	COG0745	RESPONSE REGULATOR receiver
CRV15_RS01715	COG2205	protein histidine kinase activity
CRV15_RS01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRV15_RS01760	COG2072	flavoprotein involved in K transport
CRV15_RS01785	COG1556	Lactate utilization protein
CRV15_RS01790	COG1139	Iron-sulfur cluster binding protein
CRV15_RS01795	COG0247	lactate metabolic process
CRV15_RS01840	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS01870	COG0500	methyltransferase
CRV15_RS01875	COG4981	capsule polysaccharide biosynthetic process
CRV15_RS01930	COG0477	Major facilitator Superfamily
CRV15_RS01950	COG2226	methyltransferase
CRV15_RS01960	COG0187	DNA topoisomerase II activity
CRV15_RS02000	COG0673	inositol 2-dehydrogenase activity
CRV15_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS02050	COG2850	peptidyl-arginine hydroxylation
CRV15_RS02105	COG3511	phospholipase C
CRV15_RS02220	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS02270	COG1116	anion transmembrane transporter activity
CRV15_RS02280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRV15_RS02285	COG4948	Mandelate Racemase Muconate Lactonizing
CRV15_RS02290	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS02325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CRV15_RS02330	COG1309	transcriptional regulator
CRV15_RS02340	COG0741	lytic transglycosylase activity
CRV15_RS02340	COG0739	heme binding
CRV15_RS02340	COG1196	nuclear chromosome segregation
CRV15_RS02350	COG2365	Tyrosine phosphatase family
CRV15_RS02380	COG1657	PFAM Prenyltransferase squalene oxidase
CRV15_RS02390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CRV15_RS02400	COG1562	ergosterol biosynthetic process
CRV15_RS02405	COG1134	teichoic acid transport
CRV15_RS02420	COG0371	Dehydrogenase
CRV15_RS02445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRV15_RS02480	COG2183	response to ionizing radiation
CRV15_RS02495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CRV15_RS02505	COG2936	dipeptidyl-peptidase activity
CRV15_RS02525	COG1024	Enoyl-CoA hydratase
CRV15_RS02525	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRV15_RS02530	COG0183	Belongs to the thiolase family
CRV15_RS02535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRV15_RS02540	COG3268	Saccharopine dehydrogenase
CRV15_RS02545	COG1515	deoxyribonuclease V activity
CRV15_RS02560	COG0488	(ABC) transporter
CRV15_RS02565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRV15_RS02605	COG1793	dna ligase
CRV15_RS02660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRV15_RS02705	COG3012	SEC-C Motif Domain Protein
CRV15_RS02735	COG1609	Transcriptional regulator
CRV15_RS02740	COG3345	alpha-galactosidase
CRV15_RS02840	COG0475	glutathione-regulated potassium exporter activity
CRV15_RS02855	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRV15_RS02860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRV15_RS02865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRV15_RS02955	COG1082	Xylose isomerase domain protein TIM barrel
CRV15_RS02960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CRV15_RS02980	COG0673	inositol 2-dehydrogenase activity
CRV15_RS02985	COG4213	ABC transporter substrate-binding protein
CRV15_RS02990	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRV15_RS02995	COG1129	ABC transporter
CRV15_RS03000	COG1940	carbohydrate kinase activity
CRV15_RS03010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRV15_RS03015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRV15_RS03035	COG1595	DNA-templated transcription, initiation
CRV15_RS03045	COG3250	beta-galactosidase activity
CRV15_RS03055	COG3250	beta-galactosidase activity
CRV15_RS03070	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CRV15_RS03075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRV15_RS03085	COG0656	L-ascorbic acid biosynthetic process
CRV15_RS03095	COG1793	dna ligase
CRV15_RS03140	COG1063	alcohol dehydrogenase
CRV15_RS03205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRV15_RS03210	COG1619	proteins homologs of microcin C7 resistance protein MccF
CRV15_RS03220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRV15_RS03225	COG2362	D-Aminopeptidase
CRV15_RS03280	COG0604	alcohol dehydrogenase
CRV15_RS03285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS03285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS03300	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS03305	COG0688	phosphatidylethanolamine metabolic process
CRV15_RS03315	COG1929	Belongs to the glycerate kinase type-1 family
CRV15_RS03330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CRV15_RS03335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRV15_RS03345	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRV15_RS03360	COG0483	inositol monophosphate 1-phosphatase activity
CRV15_RS03365	COG0095	Lipoate-protein ligase
CRV15_RS03375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRV15_RS03380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRV15_RS03410	COG0405	Gamma-glutamyltransferase
CRV15_RS03420	COG0765	amino acid transport
CRV15_RS03425	COG0765	amino acid transport
CRV15_RS03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRV15_RS03435	COG1126	abc transporter atp-binding protein
CRV15_RS03455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRV15_RS03465	COG1940	carbohydrate kinase activity
CRV15_RS03485	COG2188	Transcriptional regulator
CRV15_RS03490	COG0673	inositol 2-dehydrogenase activity
CRV15_RS03500	COG2197	response regulator
CRV15_RS03505	COG4585	Histidine kinase
CRV15_RS03520	COG4266	Belongs to the allantoicase family
CRV15_RS03525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRV15_RS03530	COG1414	Transcriptional regulator
CRV15_RS03545	COG0746	molybdenum cofactor guanylyltransferase activity
CRV15_RS03555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRV15_RS03570	COG1288	antiporter activity
CRV15_RS03600	COG2351	hydroxyisourate hydrolase activity
CRV15_RS03625	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS03630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRV15_RS03635	COG2197	response regulator
CRV15_RS03650	COG3409	Peptidoglycan-binding domain 1 protein
CRV15_RS03670	COG1404	Belongs to the peptidase S8 family
CRV15_RS03685	COG0243	molybdopterin cofactor binding
CRV15_RS03720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRV15_RS03735	COG2345	Transcriptional regulator
CRV15_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS03755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS03770	COG2197	response regulator
CRV15_RS03775	COG1132	(ABC) transporter
CRV15_RS03780	COG1132	(ABC) transporter
CRV15_RS03790	COG0515	serine threonine protein kinase
CRV15_RS03800	COG1609	Transcriptional regulator
CRV15_RS03845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRV15_RS03860	COG3835	regulator
CRV15_RS03865	COG1840	ABC-type Fe3 transport system, periplasmic component
CRV15_RS03875	COG3842	ATPase activity
CRV15_RS03885	COG1802	Transcriptional regulator
CRV15_RS03905	COG0028	Belongs to the TPP enzyme family
CRV15_RS03935	COG1162	GTPase activity
CRV15_RS03960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS03990	COG3290	protein histidine kinase activity
CRV15_RS04030	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS04035	COG3284	Transcriptional regulator
CRV15_RS04055	COG0175	sulfate reduction
CRV15_RS04060	COG0529	Catalyzes the synthesis of activated sulfate
CRV15_RS04080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CRV15_RS04085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRV15_RS04120	COG1175	transmembrane transport
CRV15_RS04195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRV15_RS04200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRV15_RS04225	COG1764	response to oxidative stress
CRV15_RS04230	COG1846	Transcriptional regulator
CRV15_RS04250	COG3220	belongs to the UPF0276 family
CRV15_RS04270	COG3253	May function as heme-dependent peroxidase
CRV15_RS04275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CRV15_RS04285	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRV15_RS04290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CRV15_RS04310	COG0183	Belongs to the thiolase family
CRV15_RS04315	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRV15_RS04315	COG1024	Enoyl-CoA hydratase
CRV15_RS04325	COG0531	amino acid
CRV15_RS04330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRV15_RS04335	COG4214	carbohydrate transport
CRV15_RS04345	COG4213	ABC transporter substrate-binding protein
CRV15_RS04350	COG1940	carbohydrate kinase activity
CRV15_RS04360	COG0395	ABC-type sugar transport system, permease component
CRV15_RS04365	COG1175	transmembrane transport
CRV15_RS04370	COG1653	transport
CRV15_RS04385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRV15_RS04390	COG1522	sequence-specific DNA binding
CRV15_RS04410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRV15_RS04455	COG1024	Enoyl-CoA hydratase
CRV15_RS04460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRV15_RS04470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRV15_RS04490	COG2040	homocysteine
CRV15_RS04510	COG1799	cell septum assembly
CRV15_RS04515	COG3629	intracellular signal transduction
CRV15_RS04515	COG3903	Transcriptional regulator
CRV15_RS04530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRV15_RS04550	COG4689	acetoacetate decarboxylase
CRV15_RS04580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CRV15_RS04590	COG0745	RESPONSE REGULATOR receiver
CRV15_RS04595	COG2205	protein histidine kinase activity
CRV15_RS04620	COG0756	dUTP diphosphatase activity
CRV15_RS04630	COG1136	(ABC) transporter
CRV15_RS04630	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRV15_RS04665	COG0577	efflux transmembrane transporter activity
CRV15_RS04665	COG1136	(ABC) transporter
CRV15_RS04675	COG0569	domain protein
CRV15_RS04680	COG0531	amino acid
CRV15_RS04685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRV15_RS04700	COG0483	inositol monophosphate 1-phosphatase activity
CRV15_RS04705	COG2264	protein methyltransferase activity
CRV15_RS04720	COG0494	nUDIX hydrolase
CRV15_RS04750	COG0142	geranyltranstransferase activity
CRV15_RS04805	COG2409	Drug exporters of the RND superfamily
CRV15_RS04830	COG3629	intracellular signal transduction
CRV15_RS04830	COG3903	Transcriptional regulator
CRV15_RS04840	COG2264	protein methyltransferase activity
CRV15_RS04905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRV15_RS04910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS04915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS04930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRV15_RS04940	COG0702	epimerase
CRV15_RS04955	COG1435	thymidine kinase activity
CRV15_RS04970	COG0045	succinate-CoA ligase (ADP-forming) activity
CRV15_RS04970	COG1042	CoA-binding domain protein
CRV15_RS04970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRV15_RS04975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRV15_RS04980	COG1802	Transcriptional regulator
CRV15_RS04985	COG0739	heme binding
CRV15_RS04985	COG1196	nuclear chromosome segregation
CRV15_RS04985	COG0741	lytic transglycosylase activity
CRV15_RS04995	COG0612	Peptidase, M16
CRV15_RS05000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRV15_RS05010	COG0372	Belongs to the citrate synthase family
CRV15_RS05020	COG3290	protein histidine kinase activity
CRV15_RS05025	COG4565	transcriptional regulatory protein
CRV15_RS05030	COG0187	DNA topoisomerase II activity
CRV15_RS05045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRV15_RS05050	COG2186	Transcriptional regulator
CRV15_RS05055	COG1131	(ABC) transporter
CRV15_RS05085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRV15_RS05110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRV15_RS05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRV15_RS05120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRV15_RS05150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRV15_RS05160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRV15_RS05170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CRV15_RS05180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRV15_RS05200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRV15_RS05205	COG2358	TRAP transporter, solute receptor (TAXI family
CRV15_RS05210	COG2205	protein histidine kinase activity
CRV15_RS05215	COG0745	RESPONSE REGULATOR receiver
CRV15_RS05220	COG1126	abc transporter atp-binding protein
CRV15_RS05225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRV15_RS05230	COG0765	amino acid transport
CRV15_RS05235	COG0765	amino acid transport
CRV15_RS05240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRV15_RS05255	COG2137	regulation of response to DNA damage stimulus
CRV15_RS05295	COG1201	RNA secondary structure unwinding
CRV15_RS05300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRV15_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS05315	COG0783	Belongs to the Dps family
CRV15_RS05320	COG1396	sequence-specific DNA binding
CRV15_RS05325	COG1546	Belongs to the CinA family
CRV15_RS05325	COG1058	Belongs to the CinA family
CRV15_RS05335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRV15_RS05345	COG1674	ftsk spoiiie
CRV15_RS05355	COG5002	protein histidine kinase activity
CRV15_RS05355	COG0784	Response regulator, receiver
CRV15_RS05360	COG2208	phosphoserine phosphatase activity
CRV15_RS05360	COG2770	Histidine kinase
CRV15_RS05385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CRV15_RS05390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRV15_RS05395	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CRV15_RS05415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRV15_RS05420	COG0612	Peptidase, M16
CRV15_RS05425	COG1185	polyribonucleotide nucleotidyltransferase activity
CRV15_RS05430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CRV15_RS05440	COG1674	ftsk spoiiie
CRV15_RS05455	COG1404	Belongs to the peptidase S8 family
CRV15_RS05470	COG1404	Belongs to the peptidase S8 family
CRV15_RS05475	COG3266	domain, Protein
CRV15_RS05495	COG0455	bacterial-type flagellum organization
CRV15_RS05500	COG0747	negative chemotaxis
CRV15_RS05510	COG0601	transmembrane transport
CRV15_RS05515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS05535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CRV15_RS05540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRV15_RS05550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRV15_RS05565	COG0779	Required for maturation of 30S ribosomal subunits
CRV15_RS05585	COG0442	prolyl-tRNA aminoacylation
CRV15_RS05600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CRV15_RS05605	COG0750	zinc metalloprotease
CRV15_RS05610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRV15_RS05625	COG2508	Transcriptional regulator
CRV15_RS05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRV15_RS05660	COG1177	transmembrane transport
CRV15_RS05665	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRV15_RS05670	COG3842	ATPase activity
CRV15_RS05695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRV15_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS05720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS05725	COG1136	(ABC) transporter
CRV15_RS05740	COG3842	ATPase activity
CRV15_RS05755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CRV15_RS05760	COG0575	Belongs to the CDS family
CRV15_RS05765	COG0233	cytoplasmic translational termination
CRV15_RS05770	COG0528	UMP kinase activity
CRV15_RS05775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRV15_RS05780	COG0052	Belongs to the universal ribosomal protein uS2 family
CRV15_RS05795	COG1191	sigma factor activity
CRV15_RS05810	COG0792	nuclease activity
CRV15_RS05825	COG0681	Belongs to the peptidase S26 family
CRV15_RS05840	COG0681	Belongs to the peptidase S26 family
CRV15_RS05845	COG0335	large ribosomal subunit rRNA binding
CRV15_RS05850	COG0336	Belongs to the RNA methyltransferase TrmD family
CRV15_RS05855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRV15_RS05860	COG1837	Belongs to the UPF0109 family
CRV15_RS05865	COG0228	four-way junction DNA binding
CRV15_RS05880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRV15_RS05890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CRV15_RS05920	COG4552	Acetyltransferase involved in intracellular survival and related
CRV15_RS05925	COG0477	Major facilitator Superfamily
CRV15_RS05930	COG1196	nuclear chromosome segregation
CRV15_RS05945	COG1254	Belongs to the acylphosphatase family
CRV15_RS05950	COG2340	Cysteine-rich secretory protein family
CRV15_RS05955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRV15_RS05960	COG0571	ribonuclease III activity
CRV15_RS05965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRV15_RS05980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRV15_RS05985	COG0742	ribosomal rna small subunit methyltransferase
CRV15_RS05995	COG1461	Dihydroxyacetone kinase
CRV15_RS06000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRV15_RS06005	COG0351	phosphomethylpyrimidine kinase
CRV15_RS06020	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRV15_RS06025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRV15_RS06035	COG1920	GTP binding
CRV15_RS06045	COG0776	regulation of translation
CRV15_RS06055	COG0066	3-isopropylmalate dehydratase activity
CRV15_RS06060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRV15_RS06065	COG1414	Transcriptional regulator
CRV15_RS06095	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CRV15_RS06100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRV15_RS06105	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRV15_RS06110	COG5002	protein histidine kinase activity
CRV15_RS06115	COG2018	Roadblock/LC7 domain
CRV15_RS06135	COG2018	Roadblock/LC7 domain
CRV15_RS06155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRV15_RS06175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRV15_RS06185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRV15_RS06190	COG0477	Major facilitator Superfamily
CRV15_RS06200	COG2957	Belongs to the agmatine deiminase family
CRV15_RS06205	COG0804	urea catabolic process
CRV15_RS06215	COG0832	Belongs to the urease beta subunit family
CRV15_RS06215	COG0831	urea catabolic process
CRV15_RS06240	COG0300	oxidoreductase activity
CRV15_RS06250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS06275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRV15_RS06280	COG0473	3-isopropylmalate dehydrogenase activity
CRV15_RS06290	COG1082	Xylose isomerase domain protein TIM barrel
CRV15_RS06300	COG0577	efflux transmembrane transporter activity
CRV15_RS06300	COG1136	(ABC) transporter
CRV15_RS06305	COG1136	(ABC) transporter
CRV15_RS06305	COG0577	efflux transmembrane transporter activity
CRV15_RS06355	COG0640	Transcriptional regulator
CRV15_RS06360	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS06365	COG0506	proline dehydrogenase activity
CRV15_RS06370	COG2508	Transcriptional regulator
CRV15_RS06370	COG2508	Transcriptional regulator
CRV15_RS06375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRV15_RS06380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRV15_RS06385	COG0440	acetolactate synthase activity
CRV15_RS06405	COG0667	Aldo Keto reductase
CRV15_RS06410	COG2133	pyrroloquinoline quinone binding
CRV15_RS06420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CRV15_RS06420	COG1672	PFAM Archaeal ATPase
CRV15_RS06430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRV15_RS06435	COG2409	Drug exporters of the RND superfamily
CRV15_RS06445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRV15_RS06455	COG0154	amidase activity
CRV15_RS06460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRV15_RS06470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRV15_RS06480	COG4221	oxidoreductase activity
CRV15_RS06485	COG1611	Belongs to the LOG family
CRV15_RS06495	COG0482	sulfurtransferase activity
CRV15_RS06525	COG2860	membrane
CRV15_RS06530	COG4608	Belongs to the ABC transporter superfamily
CRV15_RS06535	COG0444	Belongs to the ABC transporter superfamily
CRV15_RS06540	COG0601	transmembrane transport
CRV15_RS06545	COG0747	negative chemotaxis
CRV15_RS06550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS06570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CRV15_RS06575	COG0509	glycine decarboxylation via glycine cleavage system
CRV15_RS06580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRV15_RS06585	COG1760	l-serine dehydratase
CRV15_RS06595	COG2856	Zn peptidase
CRV15_RS06740	COG1024	Enoyl-CoA hydratase
CRV15_RS06755	COG1132	(ABC) transporter
CRV15_RS06760	COG1132	(ABC) transporter
CRV15_RS06770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRV15_RS06800	COG2197	response regulator
CRV15_RS06805	COG4585	Histidine kinase
CRV15_RS06815	COG0058	SHG alpha-glucan phosphorylase activity
CRV15_RS06820	COG0366	Alpha amylase catalytic
CRV15_RS06825	COG0366	Alpha amylase catalytic
CRV15_RS06835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CRV15_RS06850	COG1301	dicarboxylic acid transport
CRV15_RS06855	COG3290	protein histidine kinase activity
CRV15_RS06860	COG4565	transcriptional regulatory protein
CRV15_RS06865	COG0181	hydroxymethylbilane synthase activity
CRV15_RS06895	COG1175	transmembrane transport
CRV15_RS06905	COG0205	6-phosphofructokinase activity
CRV15_RS06910	COG0280	phosphate acetyltransferase
CRV15_RS06910	COG0857	belongs to the CobB CobQ family
CRV15_RS06915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRV15_RS06950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS06950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS06995	COG0745	RESPONSE REGULATOR receiver
CRV15_RS07010	COG0183	Belongs to the thiolase family
CRV15_RS07030	COG1131	(ABC) transporter
CRV15_RS07065	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CRV15_RS07080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRV15_RS07095	COG4585	Histidine kinase
CRV15_RS07100	COG2197	response regulator
CRV15_RS07110	COG1088	dTDP-glucose 4,6-dehydratase activity
CRV15_RS07130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRV15_RS07160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS07170	COG0494	nUDIX hydrolase
CRV15_RS07185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRV15_RS07190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRV15_RS07195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRV15_RS07200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CRV15_RS07205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRV15_RS07210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRV15_RS07215	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRV15_RS07235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRV15_RS07240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRV15_RS07250	COG2890	protein-(glutamine-N5) methyltransferase activity
CRV15_RS07255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRV15_RS07260	COG0254	rRNA binding
CRV15_RS07265	COG1316	TRANSCRIPTIONal
CRV15_RS07280	COG0083	homoserine kinase activity
CRV15_RS07285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRV15_RS07290	COG0460	homoserine dehydrogenase
CRV15_RS07295	COG0019	diaminopimelate decarboxylase activity
CRV15_RS07300	COG0018	arginyl-trna synthetase
CRV15_RS07360	COG1674	ftsk spoiiie
CRV15_RS07445	COG2367	Beta-lactamase
CRV15_RS07450	COG1686	Belongs to the peptidase S11 family
CRV15_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS07465	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CRV15_RS07470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRV15_RS07490	COG2192	nodulation
CRV15_RS07500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRV15_RS07510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRV15_RS07520	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CRV15_RS07525	COG0768	penicillin binding
CRV15_RS07535	COG0367	asparagine synthase
CRV15_RS07540	COG0010	Belongs to the arginase family
CRV15_RS07545	COG2175	clavaminate synthase activity
CRV15_RS07590	COG0697	spore germination
CRV15_RS07595	COG0456	acetyltransferase
CRV15_RS07600	COG0747	negative chemotaxis
CRV15_RS07610	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRV15_RS07615	COG0768	penicillin binding
CRV15_RS07620	COG0768	penicillin binding
CRV15_RS07625	COG2124	cytochrome p450
CRV15_RS07635	COG2205	protein histidine kinase activity
CRV15_RS07640	COG0745	RESPONSE REGULATOR receiver
CRV15_RS07660	COG2072	flavoprotein involved in K transport
CRV15_RS07665	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CRV15_RS07670	COG1793	dna ligase
CRV15_RS07670	COG3285	dna ligase
CRV15_RS07675	COG1793	dna ligase
CRV15_RS07730	COG0768	penicillin binding
CRV15_RS07760	COG2318	DinB family
CRV15_RS07795	COG2205	protein histidine kinase activity
CRV15_RS07815	COG1357	PFAM Pentapeptide repeats (8 copies)
CRV15_RS07820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRV15_RS07830	COG0745	RESPONSE REGULATOR receiver
CRV15_RS07835	COG2205	protein histidine kinase activity
CRV15_RS07845	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRV15_RS07845	COG0567	Dehydrogenase, E1 component
CRV15_RS07855	COG2255	four-way junction helicase activity
CRV15_RS07890	COG0604	alcohol dehydrogenase
CRV15_RS07910	COG1126	abc transporter atp-binding protein
CRV15_RS07915	COG4106	trans-aconitate 2-methyltransferase activity
CRV15_RS07935	COG0494	nUDIX hydrolase
CRV15_RS07945	COG5640	endopeptidase activity
CRV15_RS07965	COG0142	geranyltranstransferase activity
CRV15_RS08000	COG1597	lipid kinase activity
CRV15_RS08015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRV15_RS08020	COG1472	Belongs to the glycosyl hydrolase 3 family
CRV15_RS08025	COG0395	ABC-type sugar transport system, permease component
CRV15_RS08030	COG1175	transmembrane transport
CRV15_RS08035	COG2182	Extracellular solute-binding protein
CRV15_RS08040	COG2188	Transcriptional regulator
CRV15_RS08065	COG0242	peptide deformylase activity
CRV15_RS08085	COG5662	AntiSigma factor
CRV15_RS08090	COG1595	DNA-templated transcription, initiation
CRV15_RS08100	COG2135	peptidase activity
CRV15_RS08110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRV15_RS08120	COG2076	Multidrug Resistance protein
CRV15_RS08130	COG0483	inositol monophosphate 1-phosphatase activity
CRV15_RS08140	COG0753	catalase activity
CRV15_RS08165	COG1615	UPF0182 protein
CRV15_RS08175	COG3480	Lon protease (S16) C-terminal proteolytic domain
CRV15_RS08215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRV15_RS08255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRV15_RS08310	COG0601	transmembrane transport
CRV15_RS08315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS08320	COG0747	negative chemotaxis
CRV15_RS08330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRV15_RS08330	COG0596	Alpha beta hydrolase
CRV15_RS08360	COG0513	Belongs to the DEAD box helicase family
CRV15_RS08385	COG1432	Conserved Protein
CRV15_RS08390	COG2095	MarC family integral membrane protein
CRV15_RS08415	COG0598	Magnesium transport protein CorA
CRV15_RS08450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRV15_RS08455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRV15_RS08465	COG1595	DNA-templated transcription, initiation
CRV15_RS08480	COG1024	Enoyl-CoA hydratase
CRV15_RS08485	COG0519	Catalyzes the synthesis of GMP from XMP
CRV15_RS08495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRV15_RS08500	COG1611	Belongs to the LOG family
CRV15_RS08505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRV15_RS08550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRV15_RS08565	COG4608	Belongs to the ABC transporter superfamily
CRV15_RS08570	COG0444	Belongs to the ABC transporter superfamily
CRV15_RS08575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS08580	COG0601	transmembrane transport
CRV15_RS08595	COG4608	Belongs to the ABC transporter superfamily
CRV15_RS08600	COG0444	Belongs to the ABC transporter superfamily
CRV15_RS08610	COG4166	transmembrane transport
CRV15_RS08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRV15_RS08625	COG1217	gtp-binding protein TYPA
CRV15_RS08645	COG1053	succinate dehydrogenase
CRV15_RS08695	COG0012	GTP binding
CRV15_RS08710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CRV15_RS08715	COG0531	amino acid
CRV15_RS08720	COG1570	exodeoxyribonuclease VII activity
CRV15_RS08725	COG1722	exodeoxyribonuclease VII activity
CRV15_RS08730	COG0778	Nitroreductase
CRV15_RS08755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRV15_RS08755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRV15_RS08765	COG0114	fumarate hydratase activity
CRV15_RS08785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRV15_RS08805	COG1136	(ABC) transporter
CRV15_RS08820	COG0450	alkyl hydroperoxide reductase
CRV15_RS08825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRV15_RS08840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CRV15_RS08845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRV15_RS08850	COG0667	Aldo Keto reductase
CRV15_RS08875	COG2885	chlorophyll binding
CRV15_RS08895	COG2197	response regulator
CRV15_RS08900	COG4585	Histidine kinase
CRV15_RS08930	COG2894	cell division
CRV15_RS08955	COG2610	gluconate transmembrane transporter activity
CRV15_RS08960	COG0251	oxidation-reduction process
CRV15_RS08965	COG1414	Transcriptional regulator
CRV15_RS08980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CRV15_RS09040	COG0492	ferredoxin-NADP+ reductase activity
CRV15_RS09075	COG0728	peptidoglycan biosynthetic process
CRV15_RS09085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CRV15_RS09090	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS09130	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CRV15_RS09140	COG1309	transcriptional regulator
CRV15_RS09145	COG1331	Highly conserved protein containing a thioredoxin domain
CRV15_RS09175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRV15_RS09185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRV15_RS09195	COG2188	Transcriptional regulator
CRV15_RS09215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRV15_RS09255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRV15_RS09270	COG1064	alcohol dehydrogenase
CRV15_RS09285	COG2986	histidine ammonia-lyase
CRV15_RS09295	COG1024	Enoyl-CoA hydratase
CRV15_RS09310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRV15_RS09320	COG0424	maF-like protein
CRV15_RS09325	COG4770	biotin carboxylase activity
CRV15_RS09355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRV15_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS09390	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS09405	COG1595	DNA-templated transcription, initiation
CRV15_RS09410	COG0745	RESPONSE REGULATOR receiver
CRV15_RS09415	COG2205	protein histidine kinase activity
CRV15_RS09440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRV15_RS09455	COG0583	DNA-binding transcription factor activity
CRV15_RS09460	COG2814	Major facilitator Superfamily
CRV15_RS09495	COG1079	Belongs to the binding-protein-dependent transport system permease family
CRV15_RS09500	COG4603	Belongs to the binding-protein-dependent transport system permease family
CRV15_RS09505	COG3845	ABC transporter
CRV15_RS09510	COG1744	ABC transporter substrate-binding protein PnrA-like
CRV15_RS09515	COG1473	amidohydrolase
CRV15_RS09515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CRV15_RS09525	COG2089	acid synthase
CRV15_RS09530	COG1083	cytidylyl-transferase
CRV15_RS09540	COG1216	Glycosyl transferase, family 2
CRV15_RS09555	COG0517	IMP dehydrogenase activity
CRV15_RS09555	COG0516	GMP reductase activity
CRV15_RS09575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS09575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS09590	COG1595	DNA-templated transcription, initiation
CRV15_RS09600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CRV15_RS09610	COG2009	succinate dehydrogenase
CRV15_RS09620	COG1053	succinate dehydrogenase
CRV15_RS09625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRV15_RS09635	COG1408	metallophosphoesterase
CRV15_RS09645	COG1686	Belongs to the peptidase S11 family
CRV15_RS09650	COG1295	ribonuclease BN
CRV15_RS09655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CRV15_RS09680	COG0180	Tryptophanyl-tRNA synthetase
CRV15_RS09685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRV15_RS09690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRV15_RS09695	COG0754	glutathionylspermidine amidase activity
CRV15_RS09705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRV15_RS09745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRV15_RS09755	COG0039	L-malate dehydrogenase activity
CRV15_RS09770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRV15_RS09785	COG0138	bifunctional purine biosynthesis protein purh
CRV15_RS09815	COG0045	succinate-CoA ligase (ADP-forming) activity
CRV15_RS09820	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CRV15_RS09830	COG0714	Associated with various cellular activities
CRV15_RS09845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS09845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRV15_RS09855	COG0739	heme binding
CRV15_RS09875	COG2197	response regulator
CRV15_RS09900	COG0519	Catalyzes the synthesis of GMP from XMP
CRV15_RS09900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRV15_RS09920	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS09940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRV15_RS09950	COG0516	GMP reductase activity
CRV15_RS09960	COG1595	DNA-templated transcription, initiation
CRV15_RS09965	COG2197	response regulator
CRV15_RS09975	COG0583	DNA-binding transcription factor activity
CRV15_RS09990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRV15_RS09995	COG0459	protein refolding
CRV15_RS10000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRV15_RS10005	COG0726	polysaccharide deacetylase
CRV15_RS10015	COG4941	Belongs to the sigma-70 factor family
CRV15_RS10040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRV15_RS10065	COG0802	atpase or kinase
CRV15_RS10075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRV15_RS10095	COG0736	holo-[acyl-carrier-protein] synthase activity
CRV15_RS10100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRV15_RS10105	COG1072	(Pantothenic acid kinase))
CRV15_RS10110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRV15_RS10115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRV15_RS10120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRV15_RS10125	COG0488	(ABC) transporter
CRV15_RS10135	COG0101	tRNA pseudouridine synthase activity
CRV15_RS10140	COG0203	ribosomal protein L17
CRV15_RS10145	COG0202	RNA polymerase activity
CRV15_RS10150	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRV15_RS10155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRV15_RS10160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRV15_RS10165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRV15_RS10175	COG0563	adenylate kinase activity
CRV15_RS10185	COG0200	Binds to the 23S rRNA
CRV15_RS10190	COG1841	ribosomal large subunit assembly
CRV15_RS10195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRV15_RS10200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRV15_RS10205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRV15_RS10210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRV15_RS10220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRV15_RS10225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRV15_RS10230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRV15_RS10235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRV15_RS10240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRV15_RS10245	COG0255	Belongs to the universal ribosomal protein uL29 family
CRV15_RS10250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRV15_RS10255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRV15_RS10260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CRV15_RS10265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRV15_RS10270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CRV15_RS10275	COG0089	rRNA binding
CRV15_RS10280	COG0088	Forms part of the polypeptide exit tunnel
CRV15_RS10285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRV15_RS10290	COG0051	transcription antitermination factor activity, RNA binding
CRV15_RS10300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRV15_RS10305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CRV15_RS10310	COG0049	tRNA binding
CRV15_RS10315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRV15_RS10320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRV15_RS10325	COG0085	RNA polymerase activity
CRV15_RS10335	COG0222	ribosome binding
CRV15_RS10340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRV15_RS10345	COG0081	regulation of translation
CRV15_RS10350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRV15_RS10360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRV15_RS10370	COG0436	Aminotransferase
CRV15_RS10375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRV15_RS10380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CRV15_RS10390	COG2030	dehydratase
CRV15_RS10395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRV15_RS10415	COG0702	epimerase
CRV15_RS10435	COG1666	GTP binding
CRV15_RS10440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRV15_RS10450	COG3304	Inner membrane component domain
CRV15_RS10455	COG0501	Belongs to the peptidase M48B family
CRV15_RS10460	COG1007	ATP synthesis coupled electron transport
CRV15_RS10475	COG0713	ATP synthesis coupled electron transport
CRV15_RS10480	COG0839	Belongs to the complex I subunit 6 family
CRV15_RS10485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRV15_RS10495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10510	COG4585	Histidine kinase
CRV15_RS10525	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRV15_RS10525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRV15_RS10530	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRV15_RS10555	COG1733	regulation of RNA biosynthetic process
CRV15_RS10570	COG2234	aminopeptidase activity
CRV15_RS10570	COG4935	Belongs to the peptidase S8 family
CRV15_RS10595	COG0142	geranyltranstransferase activity
CRV15_RS10600	COG2936	dipeptidyl-peptidase activity
CRV15_RS10605	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRV15_RS10610	COG1007	ATP synthesis coupled electron transport
CRV15_RS10620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRV15_RS10625	COG0713	ATP synthesis coupled electron transport
CRV15_RS10630	COG0839	Belongs to the complex I subunit 6 family
CRV15_RS10635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRV15_RS10645	COG1034	ATP synthesis coupled electron transport
CRV15_RS10650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CRV15_RS10660	COG0649	NAD binding
CRV15_RS10665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRV15_RS10700	COG2226	methyltransferase
CRV15_RS10710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRV15_RS10715	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRV15_RS10725	COG1278	Cold shock
CRV15_RS10730	COG1823	symporter activity
CRV15_RS10745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRV15_RS10755	COG0163	prenyltransferase activity
CRV15_RS10760	COG0109	protoheme IX farnesyltransferase activity
CRV15_RS10765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRV15_RS10775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRV15_RS10780	COG1333	cytochrome c biogenesis protein
CRV15_RS10785	COG0785	Cytochrome C biogenesis protein
CRV15_RS10790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRV15_RS10795	COG0406	alpha-ribazole phosphatase activity
CRV15_RS10800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRV15_RS10815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRV15_RS10825	COG1742	UPF0060 membrane protein
CRV15_RS10840	COG0402	S-adenosylhomocysteine deaminase activity
CRV15_RS10845	COG1690	Belongs to the RtcB family
CRV15_RS10885	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CRV15_RS10890	COG0626	cystathionine gamma-synthase activity
CRV15_RS10905	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CRV15_RS10910	COG0018	arginyl-trna synthetase
CRV15_RS10930	COG0113	porphobilinogen synthase activity
CRV15_RS11035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRV15_RS11040	COG0596	Alpha beta hydrolase
CRV15_RS11065	COG1136	(ABC) transporter
CRV15_RS11150	COG1725	Transcriptional regulator
CRV15_RS11180	COG1309	transcriptional regulator
CRV15_RS11200	COG0702	epimerase
CRV15_RS11210	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS11235	COG0259	pyridoxamine-phosphate oxidase activity
CRV15_RS11250	COG2072	flavoprotein involved in K transport
CRV15_RS11260	COG1024	Enoyl-CoA hydratase
CRV15_RS11270	COG0456	acetyltransferase
CRV15_RS11275	COG2814	Major facilitator Superfamily
CRV15_RS11275	COG0477	Major facilitator Superfamily
CRV15_RS11280	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRV15_RS11295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRV15_RS11300	COG2271	Major facilitator Superfamily
CRV15_RS11305	COG4977	sequence-specific DNA binding
CRV15_RS11305	COG1917	Cupin 2, conserved barrel domain protein
CRV15_RS11315	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS11335	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS11340	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS11350	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS11355	COG3397	chitin binding
CRV15_RS11425	COG0596	Alpha beta hydrolase
CRV15_RS11425	COG2945	thiolester hydrolase activity
CRV15_RS11435	COG4821	SIS domain
CRV15_RS11445	COG0259	pyridoxamine-phosphate oxidase activity
CRV15_RS11465	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS11480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRV15_RS11545	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS11590	COG0726	polysaccharide deacetylase
CRV15_RS11625	COG0577	efflux transmembrane transporter activity
CRV15_RS11630	COG1136	(ABC) transporter
CRV15_RS11630	COG0577	efflux transmembrane transporter activity
CRV15_RS11670	COG0583	DNA-binding transcription factor activity
CRV15_RS11695	COG2205	protein histidine kinase activity
CRV15_RS11700	COG0745	RESPONSE REGULATOR receiver
CRV15_RS11715	COG0277	FAD linked oxidase domain protein
CRV15_RS11715	COG0247	lactate metabolic process
CRV15_RS11725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CRV15_RS11765	COG0463	Glycosyl transferase, family 2
CRV15_RS11780	COG3903	Transcriptional regulator
CRV15_RS11780	COG3629	intracellular signal transduction
CRV15_RS11795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRV15_RS11835	COG1122	ATPase activity
CRV15_RS11855	COG0667	Aldo Keto reductase
CRV15_RS11890	COG2252	PERMEase
CRV15_RS11900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRV15_RS11925	COG2814	Major facilitator Superfamily
CRV15_RS11935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRV15_RS11940	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRV15_RS11945	COG1278	Cold shock
CRV15_RS11980	COG1061	Type III restriction enzyme res subunit
CRV15_RS11990	COG3973	AAA domain
CRV15_RS12005	COG1595	DNA-templated transcription, initiation
CRV15_RS12085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CRV15_RS12090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CRV15_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS12105	COG1605	Chorismate mutase
CRV15_RS12125	COG2197	response regulator
CRV15_RS12145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRV15_RS12170	COG0191	fructose-bisphosphate aldolase activity
CRV15_RS12175	COG1105	Belongs to the carbohydrate kinase PfkB family
CRV15_RS12190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRV15_RS12195	COG2182	Extracellular solute-binding protein
CRV15_RS12220	COG0463	Glycosyl transferase, family 2
CRV15_RS12295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRV15_RS12310	COG3842	ATPase activity
CRV15_RS12320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CRV15_RS12330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRV15_RS12335	COG0215	cysteine-tRNA ligase activity
CRV15_RS12345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CRV15_RS12350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CRV15_RS12355	COG1329	Transcriptional regulator
CRV15_RS12375	COG5002	protein histidine kinase activity
CRV15_RS12385	COG0588	phosphoglycerate mutase activity
CRV15_RS12390	COG2211	Major facilitator Superfamily
CRV15_RS12415	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS12475	COG1490	D-aminoacyl-tRNA deacylase activity
CRV15_RS12490	COG3485	protocatechuate 3,4-dioxygenase
CRV15_RS12520	COG1309	transcriptional regulator
CRV15_RS12540	COG0745	RESPONSE REGULATOR receiver
CRV15_RS12545	COG1609	Transcriptional regulator
CRV15_RS12560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRV15_RS12580	COG2188	Transcriptional regulator
CRV15_RS12590	COG0737	Belongs to the 5'-nucleotidase family
CRV15_RS12590	COG1525	nuclease
CRV15_RS12590	COG4085	toxin activity
CRV15_RS12610	COG0456	acetyltransferase
CRV15_RS12615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRV15_RS12625	COG0494	nUDIX hydrolase
CRV15_RS12625	COG0406	alpha-ribazole phosphatase activity
CRV15_RS12650	COG0306	phosphate transporter
CRV15_RS12660	COG1937	Protein conserved in bacteria
CRV15_RS12680	COG0671	phosphoesterase, PA-phosphatase related
CRV15_RS12685	COG1196	nuclear chromosome segregation
CRV15_RS12685	COG0739	heme binding
CRV15_RS12685	COG0741	lytic transglycosylase activity
CRV15_RS12785	COG0579	oxidoreductase
CRV15_RS12790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRV15_RS12800	COG0739	heme binding
CRV15_RS12800	COG0741	lytic transglycosylase activity
CRV15_RS12800	COG1196	nuclear chromosome segregation
CRV15_RS12855	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRV15_RS12865	COG0513	Belongs to the DEAD box helicase family
CRV15_RS12875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRV15_RS12880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRV15_RS12915	COG0785	Cytochrome C biogenesis protein
CRV15_RS12920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRV15_RS12920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRV15_RS12930	COG1643	Atp-dependent helicase
CRV15_RS12965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRV15_RS12995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRV15_RS13000	COG0047	phosphoribosylformylglycinamidine synthase activity
CRV15_RS13005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRV15_RS13040	COG2197	response regulator
CRV15_RS13050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CRV15_RS13065	COG0151	Belongs to the GarS family
CRV15_RS13095	COG0017	Asparaginyl-tRNA synthetase
CRV15_RS13100	COG1051	belongs to the nudix hydrolase family
CRV15_RS13110	COG0105	UTP biosynthetic process
CRV15_RS13150	COG2826	transposase and inactivated derivatives, IS30 family
CRV15_RS13185	COG3903	Transcriptional regulator
CRV15_RS13185	COG3629	intracellular signal transduction
CRV15_RS13250	COG0477	Major facilitator Superfamily
CRV15_RS13280	COG2234	aminopeptidase activity
CRV15_RS13285	COG0433	COG0433 Predicted ATPase
CRV15_RS13300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRV15_RS13340	COG1191	sigma factor activity
CRV15_RS13345	COG1191	sigma factor activity
CRV15_RS13395	COG2304	oxidoreductase activity
CRV15_RS13400	COG2205	protein histidine kinase activity
CRV15_RS13405	COG0745	RESPONSE REGULATOR receiver
CRV15_RS13410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRV15_RS13435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRV15_RS13460	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS13470	COG1362	aminopeptidase activity
CRV15_RS13490	COG2271	Major facilitator Superfamily
CRV15_RS13505	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRV15_RS13510	COG0022	dehydrogenase e1 component
CRV15_RS13535	COG0515	serine threonine protein kinase
CRV15_RS13540	COG0515	serine threonine protein kinase
CRV15_RS13555	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRV15_RS13555	COG1136	(ABC) transporter
CRV15_RS13585	COG0303	'Molybdopterin
CRV15_RS13610	COG1522	sequence-specific DNA binding
CRV15_RS13615	COG1309	transcriptional regulator
CRV15_RS13620	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRV15_RS13645	COG3396	Phenylacetate-CoA oxygenase
CRV15_RS13650	COG3460	Phenylacetate-CoA oxygenase
CRV15_RS13655	COG3396	Phenylacetate-CoA oxygenase
CRV15_RS13660	COG2151	metal-sulfur cluster biosynthetic enzyme
CRV15_RS13665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRV15_RS13670	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS13675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRV15_RS13690	COG2197	response regulator
CRV15_RS13695	COG4585	Histidine kinase
CRV15_RS13720	COG0577	efflux transmembrane transporter activity
CRV15_RS13720	COG1136	(ABC) transporter
CRV15_RS13725	COG0577	efflux transmembrane transporter activity
CRV15_RS13725	COG1136	(ABC) transporter
CRV15_RS13735	COG1716	ATPase activity
CRV15_RS13740	COG1716	ATPase activity
CRV15_RS13755	COG0768	penicillin binding
CRV15_RS13760	COG0515	serine threonine protein kinase
CRV15_RS13765	COG3764	Sortase (surface protein transpeptidase)
CRV15_RS13770	COG3764	Sortase (surface protein transpeptidase)
CRV15_RS13785	COG3764	Sortase (surface protein transpeptidase)
CRV15_RS13800	COG0705	Rhomboid family
CRV15_RS13800	COG0457	Tetratricopeptide repeat
CRV15_RS13835	COG1446	asparaginase
CRV15_RS13840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRV15_RS13845	COG1280	lysine exporter protein (LysE YggA)
CRV15_RS13850	COG1672	PFAM Archaeal ATPase
CRV15_RS13850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CRV15_RS13865	COG0667	Aldo Keto reductase
CRV15_RS13870	COG2175	clavaminate synthase activity
CRV15_RS13875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRV15_RS13880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS13885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS13900	COG0515	serine threonine protein kinase
CRV15_RS13920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRV15_RS13930	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CRV15_RS13935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRV15_RS13940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CRV15_RS13945	COG0592	DNA-directed DNA polymerase activity
CRV15_RS13960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRV15_RS13965	COG0594	ribonuclease P activity
CRV15_RS13970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CRV15_RS13975	COG0706	membrane insertase activity
CRV15_RS13985	COG0357	Ribosomal RNA small subunit methyltransferase G
CRV15_RS13990	COG1192	Involved in chromosome partitioning
CRV15_RS14005	COG3118	belongs to the thioredoxin family
CRV15_RS14010	COG0492	ferredoxin-NADP+ reductase activity
CRV15_RS14020	COG1595	DNA-templated transcription, initiation
CRV15_RS14025	COG0515	serine threonine protein kinase
CRV15_RS14025	COG2815	serine threonine protein kinase
CRV15_RS14040	COG0617	tRNA 3'-terminal CCA addition
CRV15_RS14065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRV15_RS14090	COG0360	Binds together with S18 to 16S ribosomal RNA
CRV15_RS14095	COG0629	single-stranded DNA binding
CRV15_RS14100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRV15_RS14105	COG0359	binds to the 23S rRNA
CRV15_RS14115	COG0305	Participates in initiation and elongation during chromosome replication
CRV15_RS14150	COG0626	cystathionine gamma-synthase activity
CRV15_RS14155	COG1950	PFAM Membrane protein of
CRV15_RS14160	COG0662	Cupin 2, conserved barrel domain protein
CRV15_RS14180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRV15_RS14195	COG1609	Transcriptional regulator
CRV15_RS14200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRV15_RS14205	COG1271	oxidase subunit
CRV15_RS14210	COG1294	oxidase, subunit
CRV15_RS14215	COG4988	ABC transporter
CRV15_RS14225	COG0561	phosphatase activity
CRV15_RS14235	COG1131	(ABC) transporter
CRV15_RS14270	COG0561	phosphatase activity
CRV15_RS14275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRV15_RS14280	COG0077	Prephenate dehydratase
CRV15_RS14285	COG2837	iron assimilation
CRV15_RS14300	COG1999	signal sequence binding
CRV15_RS14320	COG0006	proline dipeptidase activity
CRV15_RS14350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRV15_RS14390	COG0587	DNA-directed DNA polymerase activity
CRV15_RS14395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRV15_RS14420	COG1595	DNA-templated transcription, initiation
CRV15_RS14425	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS14430	COG0784	Response regulator, receiver
CRV15_RS14460	COG0745	RESPONSE REGULATOR receiver
CRV15_RS14465	COG0477	Major facilitator Superfamily
CRV15_RS14485	COG0431	NADPH-dependent FMN reductase
CRV15_RS14515	COG1672	PFAM Archaeal ATPase
CRV15_RS14515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CRV15_RS14520	COG0431	NADPH-dependent FMN reductase
CRV15_RS14550	COG0598	Magnesium transport protein CorA
CRV15_RS14555	COG3345	alpha-galactosidase
CRV15_RS14630	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CRV15_RS14640	COG2226	methyltransferase
CRV15_RS14645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS14690	COG2826	transposase and inactivated derivatives, IS30 family
CRV15_RS14805	COG1857	crispr-associated protein
CRV15_RS14825	COG0436	Aminotransferase
CRV15_RS14835	COG2197	response regulator
CRV15_RS14845	COG0577	efflux transmembrane transporter activity
CRV15_RS14905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS14930	COG3629	intracellular signal transduction
CRV15_RS14930	COG3903	Transcriptional regulator
CRV15_RS14975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CRV15_RS14985	COG0534	Mate efflux family protein
CRV15_RS14990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS14995	COG0019	diaminopimelate decarboxylase activity
CRV15_RS15010	COG4166	transmembrane transport
CRV15_RS15015	COG0601	transmembrane transport
CRV15_RS15020	COG4171	peptide transport system, permease
CRV15_RS15035	COG2197	response regulator
CRV15_RS15040	COG4585	Histidine kinase
CRV15_RS15045	COG2409	Drug exporters of the RND superfamily
CRV15_RS15070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRV15_RS15080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRV15_RS15135	COG0717	Belongs to the dCTP deaminase family
CRV15_RS15150	COG0247	lactate metabolic process
CRV15_RS15150	COG2181	nitrate reductase activity
CRV15_RS15155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CRV15_RS15160	COG0443	Heat shock 70 kDa protein
CRV15_RS15165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRV15_RS15170	COG0484	heat shock protein binding
CRV15_RS15175	COG0789	Transcriptional regulator
CRV15_RS15195	COG0542	response to heat
CRV15_RS15225	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CRV15_RS15240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRV15_RS15245	COG0191	fructose-bisphosphate aldolase activity
CRV15_RS15250	COG0477	Major facilitator Superfamily
CRV15_RS15285	COG4585	Histidine kinase
CRV15_RS15295	COG2124	cytochrome p450
CRV15_RS15330	COG0463	Glycosyl transferase, family 2
CRV15_RS15335	COG1802	Transcriptional regulator
CRV15_RS15355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS15390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRV15_RS15405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRV15_RS15410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRV15_RS15425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRV15_RS15430	COG1595	DNA-templated transcription, initiation
CRV15_RS15460	COG2124	cytochrome p450
CRV15_RS15475	COG2091	lysine biosynthetic process via aminoadipic acid
CRV15_RS15490	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CRV15_RS15520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRV15_RS15600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRV15_RS15620	COG1408	metallophosphoesterase
CRV15_RS15625	COG1610	YqeY-like protein
CRV15_RS15630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRV15_RS15645	COG0003	Pfam Anion-transporting ATPase
CRV15_RS15675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRV15_RS15705	COG2267	carboxylic ester hydrolase activity
CRV15_RS15715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRV15_RS15720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRV15_RS15725	COG0659	secondary active sulfate transmembrane transporter activity
CRV15_RS15785	COG1205	dead DEAH box helicase
CRV15_RS15785	COG1111	helicase
CRV15_RS15790	COG1366	Belongs to the anti-sigma-factor antagonist family
CRV15_RS15795	COG2172	sigma factor antagonist activity
CRV15_RS15800	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CRV15_RS15810	COG2890	protein-(glutamine-N5) methyltransferase activity
CRV15_RS15820	COG1754	DNA topoisomerase type I activity
CRV15_RS15820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRV15_RS15830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRV15_RS15835	COG0470	DNA polymerase III
CRV15_RS15845	COG0477	Major facilitator Superfamily
CRV15_RS15885	COG1061	Type III restriction enzyme res subunit
CRV15_RS15930	COG0791	NLP P60 protein
CRV15_RS16000	COG0305	Participates in initiation and elongation during chromosome replication
CRV15_RS16165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRV15_RS16280	COG1132	(ABC) transporter
CRV15_RS16285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRV15_RS16285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRV15_RS16290	COG0110	maltose O-acetyltransferase activity
CRV15_RS16335	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS16340	COG2318	DinB family
CRV15_RS16355	COG0076	glutamate decarboxylase activity
CRV15_RS16370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRV15_RS16375	COG2027	D-alanyl-D-alanine carboxypeptidase
CRV15_RS16385	COG0037	tRNA processing
CRV15_RS16400	COG0302	gtp cyclohydrolase
CRV15_RS16415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRV15_RS16440	COG1174	glycine betaine transport
CRV15_RS16455	COG0649	NAD binding
CRV15_RS16470	COG2197	response regulator
CRV15_RS16485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CRV15_RS16490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRV15_RS16500	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CRV15_RS16520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CRV15_RS16545	COG2027	D-alanyl-D-alanine carboxypeptidase
CRV15_RS16555	COG0739	heme binding
CRV15_RS16560	COG2205	protein histidine kinase activity
CRV15_RS16565	COG0745	RESPONSE REGULATOR receiver
CRV15_RS16575	COG1595	DNA-templated transcription, initiation
CRV15_RS16580	COG1194	a g-specific adenine glycosylase
CRV15_RS16585	COG0671	phosphoesterase, PA-phosphatase related
CRV15_RS16595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CRV15_RS16615	COG0248	Ppx GppA phosphatase
CRV15_RS16625	COG0129	dihydroxy-acid dehydratase activity
CRV15_RS16645	COG2226	methyltransferase
CRV15_RS16650	COG1595	DNA-templated transcription, initiation
CRV15_RS16655	COG1252	NADH dehydrogenase
CRV15_RS16660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRV15_RS16665	COG0180	Tryptophanyl-tRNA synthetase
CRV15_RS16695	COG0123	including yeast histone deacetylase and acetoin utilization protein
CRV15_RS16730	COG1595	DNA-templated transcription, initiation
CRV15_RS16745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CRV15_RS16750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRV15_RS16755	COG0181	hydroxymethylbilane synthase activity
CRV15_RS16760	COG1648	precorrin-2 dehydrogenase activity
CRV15_RS16760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRV15_RS16785	COG1846	Transcriptional regulator
CRV15_RS16790	COG3384	dioxygenase
CRV15_RS16810	COG0477	Major facilitator Superfamily
CRV15_RS16820	COG3191	aminopeptidase activity
CRV15_RS16835	COG1970	mechanosensitive ion channel activity
CRV15_RS16845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRV15_RS16875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRV15_RS16885	COG0315	cyclic pyranopterin monophosphate synthase activity
CRV15_RS16890	COG0315	cyclic pyranopterin monophosphate synthase activity
CRV15_RS16890	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRV15_RS16895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRV15_RS16940	COG2072	flavoprotein involved in K transport
CRV15_RS16945	COG2267	carboxylic ester hydrolase activity
CRV15_RS16950	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS16955	COG4946	Tricorn protease homolog
CRV15_RS16955	COG0793	Belongs to the peptidase S41A family
CRV15_RS16965	COG2409	Drug exporters of the RND superfamily
CRV15_RS16975	COG0310	cobalt ion transport
CRV15_RS16985	COG1122	ATPase activity
CRV15_RS16990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRV15_RS17030	COG0124	histidyl-tRNA synthetase
CRV15_RS17055	COG3409	Peptidoglycan-binding domain 1 protein
CRV15_RS17080	COG0442	prolyl-tRNA aminoacylation
CRV15_RS17120	COG0084	hydrolase, TatD family'
CRV15_RS17130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRV15_RS17135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CRV15_RS17165	COG0488	(ABC) transporter
CRV15_RS17195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRV15_RS17200	COG2197	response regulator
CRV15_RS17210	COG4106	trans-aconitate 2-methyltransferase activity
CRV15_RS17215	COG1309	transcriptional regulator
CRV15_RS17225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CRV15_RS17235	COG0193	aminoacyl-tRNA hydrolase activity
CRV15_RS17240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CRV15_RS17245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRV15_RS17250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRV15_RS17260	COG4585	Histidine kinase
CRV15_RS17290	COG0477	Major facilitator Superfamily
CRV15_RS17305	COG1136	(ABC) transporter
CRV15_RS17310	COG0577	efflux transmembrane transporter activity
CRV15_RS17320	COG1595	DNA-templated transcription, initiation
CRV15_RS17345	COG0515	serine threonine protein kinase
CRV15_RS17345	COG2815	serine threonine protein kinase
CRV15_RS17375	COG1652	LysM domain
CRV15_RS17390	COG0148	phosphopyruvate hydratase activity
CRV15_RS17410	COG1252	NADH dehydrogenase
CRV15_RS17415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRV15_RS17425	COG1136	(ABC) transporter
CRV15_RS17425	COG0577	efflux transmembrane transporter activity
CRV15_RS17430	COG1136	(ABC) transporter
CRV15_RS17430	COG0577	efflux transmembrane transporter activity
CRV15_RS17460	COG0183	Belongs to the thiolase family
CRV15_RS17465	COG2755	lipolytic protein G-D-S-L family
CRV15_RS17480	COG1737	Transcriptional regulator
CRV15_RS17540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CRV15_RS17570	COG1228	amidohydrolase
CRV15_RS17595	COG1191	sigma factor activity
CRV15_RS17620	COG3104	oligopeptide transport
CRV15_RS17625	COG0745	RESPONSE REGULATOR receiver
CRV15_RS17630	COG2205	protein histidine kinase activity
CRV15_RS17665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CRV15_RS17760	COG1309	transcriptional regulator
CRV15_RS17765	COG0596	Alpha beta hydrolase
CRV15_RS17770	COG1316	TRANSCRIPTIONal
CRV15_RS17775	COG1607	acyl-coa hydrolase
CRV15_RS17780	COG1316	TRANSCRIPTIONal
CRV15_RS17800	COG1316	TRANSCRIPTIONal
CRV15_RS17825	COG0778	Nitroreductase
CRV15_RS17825	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CRV15_RS17830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRV15_RS17875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRV15_RS17880	COG2835	tetraacyldisaccharide 4'-kinase activity
CRV15_RS17890	COG1482	cell wall glycoprotein biosynthetic process
CRV15_RS17905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CRV15_RS17930	COG2826	transposase and inactivated derivatives, IS30 family
CRV15_RS17940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CRV15_RS17945	COG0745	RESPONSE REGULATOR receiver
CRV15_RS17950	COG5000	phosphorelay sensor kinase activity
CRV15_RS17950	COG5002	protein histidine kinase activity
CRV15_RS17955	COG0823	Involved in the tonB-independent uptake of proteins
CRV15_RS17965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRV15_RS17970	COG2197	response regulator
CRV15_RS17975	COG3214	Protein conserved in bacteria
CRV15_RS17985	COG0653	protein targeting
CRV15_RS18010	COG2902	Dehydrogenase
CRV15_RS18020	COG0395	ABC-type sugar transport system, permease component
CRV15_RS18025	COG1175	transmembrane transport
CRV15_RS18040	COG0515	serine threonine protein kinase
CRV15_RS18045	COG0515	serine threonine protein kinase
CRV15_RS18050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRV15_RS18060	COG2884	Cell division ATP-binding protein ftsE
CRV15_RS18070	COG0793	Belongs to the peptidase S41A family
CRV15_RS18075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CRV15_RS18090	COG0583	DNA-binding transcription factor activity
CRV15_RS18115	COG3973	AAA domain
CRV15_RS18125	COG0776	regulation of translation
CRV15_RS18130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRV15_RS18135	COG1678	Uncharacterized ACR, COG1678
CRV15_RS18150	COG1175	transmembrane transport
CRV15_RS18155	COG0395	ABC-type sugar transport system, permease component
CRV15_RS18160	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CRV15_RS18200	COG3654	unkown
CRV15_RS18225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CRV15_RS18230	COG0745	RESPONSE REGULATOR receiver
CRV15_RS18235	COG5002	protein histidine kinase activity
CRV15_RS18255	COG0277	FAD linked oxidase domain protein
CRV15_RS18295	COG1335	isochorismatase
CRV15_RS18305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CRV15_RS18315	COG1113	amino acid transport
CRV15_RS18325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRV15_RS18330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS18335	COG1120	ATPase activity
CRV15_RS18350	COG1234	tRNA 3'-trailer cleavage
CRV15_RS18355	COG1263	PTS System
CRV15_RS18360	COG1263	PTS System
CRV15_RS18370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRV15_RS18375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CRV15_RS18385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRV15_RS18415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRV15_RS18430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRV15_RS18455	COG2733	membrane
CRV15_RS18485	COG0706	membrane insertase activity
CRV15_RS18495	COG0673	inositol 2-dehydrogenase activity
CRV15_RS18570	COG1126	abc transporter atp-binding protein
CRV15_RS18575	COG0765	amino acid transport
CRV15_RS18580	COG0765	amino acid transport
CRV15_RS18590	COG0154	amidase activity
CRV15_RS18600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS18635	COG0406	alpha-ribazole phosphatase activity
CRV15_RS18675	COG0745	RESPONSE REGULATOR receiver
CRV15_RS18690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CRV15_RS18695	COG4977	sequence-specific DNA binding
CRV15_RS18705	COG0589	response to stress
CRV15_RS18710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRV15_RS18735	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CRV15_RS18740	COG0076	glutamate decarboxylase activity
CRV15_RS18750	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS18765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRV15_RS18770	COG1309	transcriptional regulator
CRV15_RS18780	COG2124	cytochrome p450
CRV15_RS18785	COG1946	Acyl-CoA thioesterase
CRV15_RS18800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRV15_RS18810	COG3960	tartronate-semialdehyde synthase activity
CRV15_RS18830	COG1674	ftsk spoiiie
CRV15_RS18890	COG1472	Belongs to the glycosyl hydrolase 3 family
CRV15_RS18905	COG1609	Transcriptional regulator
CRV15_RS18910	COG0673	inositol 2-dehydrogenase activity
CRV15_RS18925	COG1595	DNA-templated transcription, initiation
CRV15_RS18935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRV15_RS18960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRV15_RS18970	COG3718	enzyme involved in inositol metabolism
CRV15_RS18975	COG3962	Belongs to the TPP enzyme family
CRV15_RS18995	COG1131	(ABC) transporter
CRV15_RS19055	COG0105	UTP biosynthetic process
CRV15_RS19060	COG2197	response regulator
CRV15_RS19070	COG2954	triphosphatase activity
CRV15_RS19080	COG0494	nUDIX hydrolase
CRV15_RS19110	COG0561	phosphatase activity
CRV15_RS19120	COG0475	glutathione-regulated potassium exporter activity
CRV15_RS19150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRV15_RS19160	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CRV15_RS19165	COG1518	maintenance of DNA repeat elements
CRV15_RS19175	COG1203	CRISPR-associated helicase, Cas3
CRV15_RS19215	COG0629	single-stranded DNA binding
CRV15_RS19245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRV15_RS19290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRV15_RS19305	COG1486	melibiose metabolic process
CRV15_RS19310	COG0395	ABC-type sugar transport system, permease component
CRV15_RS19315	COG1175	transmembrane transport
CRV15_RS19335	COG0668	transmembrane transport
CRV15_RS19410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRV15_RS19415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRV15_RS19425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRV15_RS19435	COG0588	phosphoglycerate mutase activity
CRV15_RS19440	COG1113	amino acid transport
CRV15_RS19450	COG1113	amino acid transport
CRV15_RS19465	COG4552	Acetyltransferase involved in intracellular survival and related
CRV15_RS19480	COG0475	glutathione-regulated potassium exporter activity
CRV15_RS19495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRV15_RS19500	COG3594	Acyltransferase
CRV15_RS19520	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRV15_RS19525	COG0740	serine-type endopeptidase activity
CRV15_RS19530	COG0740	serine-type endopeptidase activity
CRV15_RS19535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRV15_RS19545	COG0525	valine-tRNA ligase activity
CRV15_RS19550	COG4585	Histidine kinase
CRV15_RS19555	COG0285	dihydrofolate synthase activity
CRV15_RS19565	COG0105	UTP biosynthetic process
CRV15_RS19570	COG1077	Cell shape determining protein MreB Mrl
CRV15_RS19590	COG0772	Belongs to the SEDS family
CRV15_RS19610	COG1530	ribonuclease E activity
CRV15_RS19620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CRV15_RS19625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRV15_RS19630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRV15_RS19635	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS19650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CRV15_RS19660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRV15_RS19675	COG0501	Belongs to the peptidase M48B family
CRV15_RS19680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CRV15_RS19690	COG0799	negative regulation of ribosome biogenesis
CRV15_RS19695	COG0588	phosphoglycerate mutase activity
CRV15_RS19720	COG0495	leucyl-tRNA aminoacylation
CRV15_RS19730	COG1307	EDD domain protein, DegV family
CRV15_RS19765	COG0268	Binds directly to 16S ribosomal RNA
CRV15_RS19770	COG0481	GTPase activity
CRV15_RS19795	COG1420	regulation of RNA biosynthetic process
CRV15_RS19800	COG0484	heat shock protein binding
CRV15_RS19820	COG4946	Tricorn protease homolog
CRV15_RS19820	COG0793	Belongs to the peptidase S41A family
CRV15_RS19825	COG0537	adenosine 5'-monophosphoramidase activity
CRV15_RS19830	COG1234	tRNA 3'-trailer cleavage
CRV15_RS19835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRV15_RS19840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRV15_RS19850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CRV15_RS19890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CRV15_RS19910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRV15_RS19925	COG1381	Involved in DNA repair and RecF pathway recombination
CRV15_RS19930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRV15_RS19940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRV15_RS19945	COG3842	ATPase activity
CRV15_RS19950	COG3443	Belongs to the bacterial solute-binding protein 9 family
CRV15_RS19950	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRV15_RS19955	COG0423	glycine-tRNA ligase activity
CRV15_RS19995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRV15_RS19995	COG0574	Belongs to the PEP-utilizing enzyme family
CRV15_RS20010	COG0531	amino acid
CRV15_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS20025	COG2890	protein-(glutamine-N5) methyltransferase activity
CRV15_RS20045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CRV15_RS20065	COG2949	membrane
CRV15_RS20070	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CRV15_RS20080	COG0358	DNA primase activity
CRV15_RS20085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRV15_RS20100	COG1070	Carbohydrate kinase
CRV15_RS20135	COG1129	ABC transporter
CRV15_RS20135	COG0842	Transport permease protein
CRV15_RS20195	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS20205	COG1136	(ABC) transporter
CRV15_RS20260	COG2130	NADP-dependent
CRV15_RS20295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRV15_RS20300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS20305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRV15_RS20330	COG0789	Transcriptional regulator
CRV15_RS20335	COG0667	Aldo Keto reductase
CRV15_RS20340	COG2197	response regulator
CRV15_RS20345	COG4585	Histidine kinase
CRV15_RS20365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS20370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRV15_RS20415	COG1358	cellular component organization or biogenesis
CRV15_RS20425	COG0586	Pfam SNARE associated Golgi protein
CRV15_RS20450	COG0582	viral genome integration into host DNA
CRV15_RS20565	COG4122	O-methyltransferase activity
CRV15_RS20575	COG2124	cytochrome p450
CRV15_RS20580	COG0183	Belongs to the thiolase family
CRV15_RS20595	COG3845	ABC transporter
CRV15_RS20630	COG1309	transcriptional regulator
CRV15_RS20635	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS20640	COG2226	methyltransferase
CRV15_RS20650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS20670	COG0183	Belongs to the thiolase family
CRV15_RS20685	COG2030	dehydratase
CRV15_RS20690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CRV15_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS20705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRV15_RS20725	COG0800	Aldolase
CRV15_RS20730	COG3022	response to hydroperoxide
CRV15_RS20745	COG0789	Transcriptional regulator
CRV15_RS20765	COG1349	DNA-binding transcription factor activity
CRV15_RS20770	COG1653	transport
CRV15_RS20780	COG0395	ABC-type sugar transport system, permease component
CRV15_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS20830	COG3540	Alkaline phosphatase
CRV15_RS20835	COG2814	Major facilitator Superfamily
CRV15_RS20850	COG1834	amidinotransferase
CRV15_RS20870	COG1120	ATPase activity
CRV15_RS20875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS20905	COG5398	heme oxygenase
CRV15_RS20935	COG1994	Peptidase M50
CRV15_RS20955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CRV15_RS20965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRV15_RS20965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRV15_RS20970	COG2132	Multicopper oxidase
CRV15_RS21005	COG0174	glutamine synthetase
CRV15_RS21020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CRV15_RS21035	COG1228	amidohydrolase
CRV15_RS21050	COG2154	pterin-4-alpha-carbinolamine dehydratase
CRV15_RS21055	COG0494	nUDIX hydrolase
CRV15_RS21075	COG2154	pterin-4-alpha-carbinolamine dehydratase
CRV15_RS21095	COG1609	Transcriptional regulator
CRV15_RS21100	COG0366	Alpha amylase catalytic
CRV15_RS21105	COG3833	ABC-type maltose transport systems, permease component
CRV15_RS21110	COG1175	transmembrane transport
CRV15_RS21140	COG2197	response regulator
CRV15_RS21180	COG0745	RESPONSE REGULATOR receiver
CRV15_RS21190	COG0673	inositol 2-dehydrogenase activity
CRV15_RS21215	COG0181	hydroxymethylbilane synthase activity
CRV15_RS21275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CRV15_RS21280	COG0321	lipoyl(octanoyl) transferase activity
CRV15_RS21295	COG1090	epimerase
CRV15_RS21325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRV15_RS21335	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRV15_RS21340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRV15_RS21345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRV15_RS21350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CRV15_RS21360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRV15_RS21390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRV15_RS21395	COG1132	(ABC) transporter
CRV15_RS21420	COG4585	Histidine kinase
CRV15_RS21425	COG2197	response regulator
CRV15_RS21430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRV15_RS21440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CRV15_RS21460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRV15_RS21470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRV15_RS21475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRV15_RS21485	COG1376	ErfK ybiS ycfS ynhG family protein
CRV15_RS21495	COG1845	cytochrome c oxidase, subunit III
CRV15_RS21500	COG2010	Cytochrome c
CRV15_RS21505	COG0723	plastoquinol--plastocyanin reductase activity
CRV15_RS21510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CRV15_RS21515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRV15_RS21520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRV15_RS21525	COG1929	Belongs to the glycerate kinase type-1 family
CRV15_RS21535	COG0745	RESPONSE REGULATOR receiver
CRV15_RS21540	COG2205	protein histidine kinase activity
CRV15_RS21595	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS21620	COG0003	Pfam Anion-transporting ATPase
CRV15_RS21630	COG1940	carbohydrate kinase activity
CRV15_RS21660	COG2197	response regulator
CRV15_RS21665	COG0205	6-phosphofructokinase activity
CRV15_RS21675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CRV15_RS21680	COG0243	molybdopterin cofactor binding
CRV15_RS21685	COG2193	ferroxidase activity
CRV15_RS21690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CRV15_RS21695	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRV15_RS21700	COG0515	serine threonine protein kinase
CRV15_RS21700	COG2815	serine threonine protein kinase
CRV15_RS21705	COG2022	thiamine diphosphate biosynthetic process
CRV15_RS21715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRV15_RS21715	COG2022	thiamine diphosphate biosynthetic process
CRV15_RS21725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRV15_RS21735	COG0352	thiamine-phosphate diphosphorylase activity
CRV15_RS21750	COG1233	COG1233 Phytoene dehydrogenase and related
CRV15_RS21760	COG1309	transcriptional regulator
CRV15_RS21765	COG1511	domain protein
CRV15_RS21770	COG1121	(ABC) transporter
CRV15_RS21800	COG0714	Associated with various cellular activities
CRV15_RS21810	COG0275	rRNA processing
CRV15_RS21820	COG0768	penicillin binding
CRV15_RS21825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRV15_RS21830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRV15_RS21835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRV15_RS21840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRV15_RS21850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRV15_RS21855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRV15_RS21870	COG1496	oxidoreductase activity
CRV15_RS21880	COG1799	cell septum assembly
CRV15_RS21890	COG3599	regulation of cell shape
CRV15_RS21895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRV15_RS21910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRV15_RS21960	COG0587	DNA-directed DNA polymerase activity
CRV15_RS21965	COG1432	Conserved Protein
CRV15_RS21985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRV15_RS22005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRV15_RS22010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRV15_RS22015	COG0131	Imidazoleglycerol-phosphate dehydratase
CRV15_RS22020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CRV15_RS22025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRV15_RS22030	COG0251	oxidation-reduction process
CRV15_RS22035	COG0107	imidazoleglycerol-phosphate synthase activity
CRV15_RS22050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRV15_RS22055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRV15_RS22075	COG0134	indole-3-glycerol-phosphate synthase activity
CRV15_RS22085	COG0133	tryptophan synthase activity
CRV15_RS22090	COG0159	tryptophan synthase activity
CRV15_RS22100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRV15_RS22105	COG2301	Belongs to the HpcH HpaI aldolase family
CRV15_RS22110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRV15_RS22115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRV15_RS22155	COG0070	glutamate synthase
CRV15_RS22155	COG0069	glutamate synthase activity
CRV15_RS22155	COG0067	glutamate synthase
CRV15_RS22180	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS22190	COG1309	transcriptional regulator
CRV15_RS22195	COG0183	Belongs to the thiolase family
CRV15_RS22225	COG1024	Enoyl-CoA hydratase
CRV15_RS22235	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS22250	COG0366	Alpha amylase catalytic
CRV15_RS22250	COG1470	cell adhesion involved in biofilm formation
CRV15_RS22265	COG1605	Chorismate mutase
CRV15_RS22265	COG0287	Prephenate dehydrogenase
CRV15_RS22320	COG0411	ABC transporter
CRV15_RS22340	COG2050	protein possibly involved in aromatic compounds catabolism
CRV15_RS22370	COG1643	Atp-dependent helicase
CRV15_RS22375	COG2226	methyltransferase
CRV15_RS22375	COG0596	Alpha beta hydrolase
CRV15_RS22375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRV15_RS22380	COG0539	negative regulation of cytoplasmic translation
CRV15_RS22390	COG0237	dephospho-CoA kinase activity
CRV15_RS22410	COG0330	HflC and HflK could
CRV15_RS22415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CRV15_RS22445	COG2313	pseudouridylate synthase activity
CRV15_RS22455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRV15_RS22460	COG0584	glycerophosphoryl diester phosphodiesterase
CRV15_RS22470	COG0556	nucleotide-excision repair
CRV15_RS22490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRV15_RS22500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRV15_RS22505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRV15_RS22505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRV15_RS22530	COG0322	excinuclease ABC activity
CRV15_RS22535	COG1660	Displays ATPase and GTPase activities
CRV15_RS22540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRV15_RS22545	COG1481	regulation of sporulation
CRV15_RS22560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRV15_RS22565	COG0126	phosphoglycerate kinase activity
CRV15_RS22570	COG0149	triose-phosphate isomerase activity
CRV15_RS22575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRV15_RS22585	COG0166	Belongs to the GPI family
CRV15_RS22590	COG3402	PFAM membrane-flanked domain
CRV15_RS22600	COG0363	glucosamine-6-phosphate deaminase activity
CRV15_RS22615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRV15_RS22625	COG0109	protoheme IX farnesyltransferase activity
CRV15_RS22655	COG1131	(ABC) transporter
CRV15_RS22670	COG0719	Fe-S assembly protein
CRV15_RS22680	COG0396	ATPase activity
CRV15_RS22685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRV15_RS22690	COG0822	iron-sulfur transferase activity
CRV15_RS22695	COG2151	metal-sulfur cluster biosynthetic enzyme
CRV15_RS22700	COG2171	N-acyltransferase activity
CRV15_RS22710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRV15_RS22760	COG2205	protein histidine kinase activity
CRV15_RS22765	COG0745	RESPONSE REGULATOR receiver
CRV15_RS22785	COG1802	Transcriptional regulator
CRV15_RS22800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRV15_RS22805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRV15_RS22815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRV15_RS22825	COG0768	penicillin binding
CRV15_RS22830	COG2197	response regulator
CRV15_RS22835	COG4585	Histidine kinase
CRV15_RS22840	COG1414	Transcriptional regulator
CRV15_RS22865	COG1902	pentaerythritol trinitrate reductase activity
CRV15_RS22870	COG5285	phytanoyl-CoA dioxygenase
CRV15_RS22875	COG1917	Cupin 2, conserved barrel domain protein
CRV15_RS22890	COG0134	indole-3-glycerol-phosphate synthase activity
CRV15_RS22920	COG1797	cobyrinic acid a,c-diamide synthase activity
CRV15_RS22935	COG1492	cobalamin metabolic process
CRV15_RS22940	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CRV15_RS22955	COG0235	Class ii aldolase
CRV15_RS22970	COG0488	(ABC) transporter
CRV15_RS22980	COG1024	Enoyl-CoA hydratase
CRV15_RS23020	COG3387	PFAM Glycoside hydrolase 15-related
CRV15_RS23055	COG1404	Belongs to the peptidase S8 family
CRV15_RS23065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRV15_RS23070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRV15_RS23090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CRV15_RS23105	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS23110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRV15_RS23120	COG2186	Transcriptional regulator
CRV15_RS23125	COG2807	transmembrane transport
CRV15_RS23140	COG0560	Phosphoserine phosphatase
CRV15_RS23140	COG3830	Belongs to the UPF0237 family
CRV15_RS23145	COG0842	Transport permease protein
CRV15_RS23145	COG1131	(ABC) transporter
CRV15_RS23145	COG1716	ATPase activity
CRV15_RS23155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CRV15_RS23165	COG4585	Histidine kinase
CRV15_RS23170	COG2197	response regulator
CRV15_RS23185	COG1119	ATPase activity
CRV15_RS23210	COG1881	PFAM PEBP family protein
CRV15_RS23220	COG2094	Belongs to the DNA glycosylase MPG family
CRV15_RS23260	COG0647	UMP catabolic process
CRV15_RS23265	COG1120	ATPase activity
CRV15_RS23285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRV15_RS23290	COG0497	DNA recombination
CRV15_RS23295	COG0297	glycogen (starch) synthase activity
CRV15_RS23305	COG3387	PFAM Glycoside hydrolase 15-related
CRV15_RS23310	COG0504	CTP synthase activity
CRV15_RS23315	COG0494	nUDIX hydrolase
CRV15_RS23325	COG0686	Belongs to the AlaDH PNT family
CRV15_RS23340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CRV15_RS23345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CRV15_RS23350	COG1187	pseudouridine synthase activity
CRV15_RS23355	COG1051	belongs to the nudix hydrolase family
CRV15_RS23355	COG1056	cytidyltransferase-related domain
CRV15_RS23380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CRV15_RS23390	COG1160	GTP binding
CRV15_RS23410	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS23420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRV15_RS23430	COG0671	phosphoesterase, PA-phosphatase related
CRV15_RS23435	COG0477	Major facilitator Superfamily
CRV15_RS23440	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS23445	COG1799	cell septum assembly
CRV15_RS23505	COG3903	Transcriptional regulator
CRV15_RS23505	COG3629	intracellular signal transduction
CRV15_RS23510	COG0596	Alpha beta hydrolase
CRV15_RS23535	COG4565	transcriptional regulatory protein
CRV15_RS23560	COG1725	Transcriptional regulator
CRV15_RS23575	COG2755	lipolytic protein G-D-S-L family
CRV15_RS23585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRV15_RS23590	COG2188	Transcriptional regulator
CRV15_RS23595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CRV15_RS23600	COG2851	Citrate transporter
CRV15_RS23635	COG3876	Protein conserved in bacteria
CRV15_RS23650	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS23665	COG2149	membrane
CRV15_RS23685	COG3265	gluconokinase activity
CRV15_RS23690	COG2186	Transcriptional regulator
CRV15_RS23695	COG1113	amino acid transport
CRV15_RS23725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRV15_RS23755	COG0667	Aldo Keto reductase
CRV15_RS23760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS23770	COG0598	Magnesium transport protein CorA
CRV15_RS23790	COG0215	cysteine-tRNA ligase activity
CRV15_RS23800	COG4948	Mandelate Racemase Muconate Lactonizing
CRV15_RS23805	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS23815	COG1129	ABC transporter
CRV15_RS23825	COG2186	Transcriptional regulator
CRV15_RS23830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRV15_RS23835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRV15_RS23840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRV15_RS23845	COG1414	Transcriptional regulator
CRV15_RS23850	COG0646	methionine synthase
CRV15_RS23850	COG1410	methionine synthase
CRV15_RS23855	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS23870	COG2197	response regulator
CRV15_RS23880	COG1994	Peptidase M50
CRV15_RS23880	COG0517	IMP dehydrogenase activity
CRV15_RS23905	COG1222	aaa ATPase
CRV15_RS23910	COG4122	O-methyltransferase activity
CRV15_RS23925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRV15_RS23930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRV15_RS23935	COG1609	Transcriptional regulator
CRV15_RS23945	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRV15_RS23980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRV15_RS23985	COG0805	protein transport
CRV15_RS24020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRV15_RS24025	COG4175	Glycine betaine
CRV15_RS24025	COG0517	IMP dehydrogenase activity
CRV15_RS24045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRV15_RS24050	COG1113	amino acid transport
CRV15_RS24055	COG2186	Transcriptional regulator
CRV15_RS24060	COG0174	glutamine synthetase
CRV15_RS24085	COG1404	Belongs to the peptidase S8 family
CRV15_RS24105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CRV15_RS24110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRV15_RS24115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CRV15_RS24120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRV15_RS24125	COG5002	protein histidine kinase activity
CRV15_RS24130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRV15_RS24135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRV15_RS24135	COG0072	phenylalanine-tRNA ligase activity
CRV15_RS24155	COG1649	PFAM Uncharacterised BCR, COG1649
CRV15_RS24165	COG0697	spore germination
CRV15_RS24175	COG2838	Isocitrate dehydrogenase
CRV15_RS24205	COG4585	Histidine kinase
CRV15_RS24210	COG2197	response regulator
CRV15_RS24215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CRV15_RS24220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CRV15_RS24225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRV15_RS24230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRV15_RS24235	COG1438	arginine binding
CRV15_RS24240	COG0137	argininosuccinate synthase activity
CRV15_RS24245	COG0165	Argininosuccinate lyase
CRV15_RS24255	COG0477	Major facilitator Superfamily
CRV15_RS24260	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS24260	COG0204	Acyl-transferase
CRV15_RS24265	COG0584	glycerophosphoryl diester phosphodiesterase
CRV15_RS24285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRV15_RS24290	COG2011	ABC-type metal ion transport system permease component
CRV15_RS24295	COG1464	Belongs to the NlpA lipoprotein family
CRV15_RS24310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRV15_RS24320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRV15_RS24320	COG1648	precorrin-2 dehydrogenase activity
CRV15_RS24365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRV15_RS24375	COG0456	acetyltransferase
CRV15_RS24420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRV15_RS24425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRV15_RS24430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRV15_RS24455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRV15_RS24460	COG1560	Kdo2-lipid A biosynthetic process
CRV15_RS24465	COG0438	transferase activity, transferring glycosyl groups
CRV15_RS24475	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CRV15_RS24480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CRV15_RS24485	COG0217	transcriptional regulatory protein
CRV15_RS24490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CRV15_RS24495	COG0632	four-way junction helicase activity
CRV15_RS24500	COG2255	four-way junction helicase activity
CRV15_RS24510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRV15_RS24515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRV15_RS24520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRV15_RS24525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRV15_RS24535	COG1196	nuclear chromosome segregation
CRV15_RS24540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRV15_RS24550	COG0124	histidyl-tRNA synthetase
CRV15_RS24570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRV15_RS24585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRV15_RS24590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRV15_RS24595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CRV15_RS24600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRV15_RS24605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRV15_RS24610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRV15_RS24615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CRV15_RS24620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CRV15_RS24630	COG0006	proline dipeptidase activity
CRV15_RS24635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRV15_RS24640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRV15_RS24650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CRV15_RS24655	COG0540	Belongs to the ATCase OTCase family
CRV15_RS24660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRV15_RS24670	COG0505	Belongs to the CarA family
CRV15_RS24675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRV15_RS24680	COG0167	dihydroorotate dehydrogenase activity
CRV15_RS24685	COG0284	orotidine-5'-phosphate decarboxylase activity
CRV15_RS24710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRV15_RS24735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRV15_RS24745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRV15_RS24750	COG2390	Transcriptional regulator
CRV15_RS24780	COG1191	sigma factor activity
CRV15_RS24790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRV15_RS24805	COG2233	PERMEase
CRV15_RS24815	COG0738	Major facilitator superfamily
CRV15_RS24820	COG1846	Transcriptional regulator
CRV15_RS24820	COG1940	carbohydrate kinase activity
CRV15_RS24835	COG3201	nicotinamide mononucleotide transporter
CRV15_RS24840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRV15_RS24840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRV15_RS24845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRV15_RS24850	COG0140	phosphoribosyl-ATP diphosphatase activity
CRV15_RS24855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CRV15_RS24895	COG1309	transcriptional regulator
CRV15_RS24900	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS24920	COG1216	Glycosyl transferase, family 2
CRV15_RS24935	COG2270	Major facilitator Superfamily
CRV15_RS24945	COG2364	Membrane
CRV15_RS24950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRV15_RS24980	COG1984	allophanate hydrolase subunit 2
CRV15_RS24985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRV15_RS24990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CRV15_RS24995	COG2814	Major facilitator Superfamily
CRV15_RS25025	COG5002	protein histidine kinase activity
CRV15_RS25030	COG2018	Roadblock/LC7 domain
CRV15_RS25045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRV15_RS25050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRV15_RS25055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRV15_RS25075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRV15_RS25085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRV15_RS25115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRV15_RS25135	COG1716	ATPase activity
CRV15_RS25155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRV15_RS25165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRV15_RS25165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRV15_RS25235	COG0697	spore germination
CRV15_RS25295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRV15_RS25315	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRV15_RS25325	COG2813	Specifically methylates the guanine in position
CRV15_RS25340	COG1968	undecaprenyl-diphosphatase activity
CRV15_RS25355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRV15_RS25380	COG2124	cytochrome p450
CRV15_RS25410	COG0110	maltose O-acetyltransferase activity
CRV15_RS25415	COG1832	CoA-binding protein
CRV15_RS25420	COG1739	Uncharacterized protein family UPF0029
CRV15_RS25430	COG0666	response to abiotic stimulus
CRV15_RS25435	COG0420	3'-5' exonuclease activity
CRV15_RS25440	COG0419	ATPase involved in DNA repair
CRV15_RS25440	COG0419	ATPase involved in DNA repair
CRV15_RS25445	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS25475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRV15_RS25490	COG2188	Transcriptional regulator
CRV15_RS25495	COG1940	carbohydrate kinase activity
CRV15_RS25505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRV15_RS25540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRV15_RS25545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS25550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRV15_RS25570	COG0740	serine-type endopeptidase activity
CRV15_RS25580	COG0831	urea catabolic process
CRV15_RS25585	COG0832	Belongs to the urease beta subunit family
CRV15_RS25590	COG0804	urea catabolic process
CRV15_RS25600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRV15_RS25605	COG0829	nickel cation binding
CRV15_RS25615	COG0204	Acyl-transferase
CRV15_RS25630	COG0142	geranyltranstransferase activity
CRV15_RS25635	COG0142	geranyltranstransferase activity
CRV15_RS25650	COG0205	6-phosphofructokinase activity
CRV15_RS25655	COG3442	glutamine amidotransferase
CRV15_RS25665	COG0242	peptide deformylase activity
CRV15_RS25675	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS25705	COG0386	Belongs to the glutathione peroxidase family
CRV15_RS25710	COG1946	Acyl-CoA thioesterase
CRV15_RS25730	COG2375	cellular response to nickel ion
CRV15_RS25730	COG1132	(ABC) transporter
CRV15_RS25735	COG1132	(ABC) transporter
CRV15_RS25745	COG2409	Drug exporters of the RND superfamily
CRV15_RS25760	COG2124	cytochrome p450
CRV15_RS25770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRV15_RS25780	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS25795	COG0477	Major facilitator Superfamily
CRV15_RS25825	COG4585	Histidine kinase
CRV15_RS25830	COG2197	response regulator
CRV15_RS25850	COG2409	Drug exporters of the RND superfamily
CRV15_RS25860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRV15_RS25860	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRV15_RS25865	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRV15_RS25920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRV15_RS25925	COG0604	alcohol dehydrogenase
CRV15_RS25925	COG3321	synthase
CRV15_RS25940	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS25960	COG1132	(ABC) transporter
CRV15_RS25965	COG2072	flavoprotein involved in K transport
CRV15_RS26030	COG0443	Heat shock 70 kDa protein
CRV15_RS26045	COG1309	transcriptional regulator
CRV15_RS26055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS26060	COG1902	pentaerythritol trinitrate reductase activity
CRV15_RS26120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRV15_RS26170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS26175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS26180	COG1120	ATPase activity
CRV15_RS26190	COG1132	(ABC) transporter
CRV15_RS26215	COG4607	ABC-type enterochelin transport system periplasmic component
CRV15_RS26220	COG0464	growth
CRV15_RS26225	COG1404	Belongs to the peptidase S8 family
CRV15_RS26230	COG1674	ftsk spoiiie
CRV15_RS26295	COG1278	Cold shock
CRV15_RS26310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CRV15_RS26320	COG1136	(ABC) transporter
CRV15_RS26320	COG0577	efflux transmembrane transporter activity
CRV15_RS26325	COG1136	(ABC) transporter
CRV15_RS26325	COG0577	efflux transmembrane transporter activity
CRV15_RS26340	COG0745	RESPONSE REGULATOR receiver
CRV15_RS26345	COG2205	protein histidine kinase activity
CRV15_RS26380	COG0463	Glycosyl transferase, family 2
CRV15_RS26385	COG0326	Molecular chaperone. Has ATPase activity
CRV15_RS26425	COG0309	Hydrogenase expression formation protein (HypE)
CRV15_RS26435	COG0298	carbon dioxide binding
CRV15_RS26445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRV15_RS26450	COG0375	protein maturation
CRV15_RS26535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRV15_RS26570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRV15_RS26585	COG2706	6-phosphogluconolactonase activity
CRV15_RS26600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRV15_RS26630	COG1309	transcriptional regulator
CRV15_RS26635	COG0671	phosphoesterase, PA-phosphatase related
CRV15_RS26660	COG0584	glycerophosphoryl diester phosphodiesterase
CRV15_RS26680	COG0204	Acyl-transferase
CRV15_RS26695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRV15_RS26715	COG3345	alpha-galactosidase
CRV15_RS26725	COG1175	transmembrane transport
CRV15_RS26730	COG0395	ABC-type sugar transport system, permease component
CRV15_RS26755	COG0644	oxidoreductase
CRV15_RS26770	COG1940	carbohydrate kinase activity
CRV15_RS26790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS26800	COG1349	DNA-binding transcription factor activity
CRV15_RS26820	COG1215	transferase activity, transferring glycosyl groups
CRV15_RS26825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRV15_RS26910	COG1486	melibiose metabolic process
CRV15_RS26960	COG1012	belongs to the aldehyde dehydrogenase family
CRV15_RS26965	COG0363	glucosamine-6-phosphate deaminase activity
CRV15_RS26990	COG1461	Dihydroxyacetone kinase
CRV15_RS26995	COG2376	Dihydroxyacetone kinase
CRV15_RS27030	COG1131	(ABC) transporter
CRV15_RS27085	COG1846	Transcriptional regulator
CRV15_RS27120	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CRV15_RS27125	COG1959	2 iron, 2 sulfur cluster binding
CRV15_RS27130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRV15_RS27130	COG1017	nitric oxide dioxygenase activity
CRV15_RS27150	COG3511	phospholipase C
CRV15_RS27160	COG1796	DNA polymerase
CRV15_RS27160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CRV15_RS27170	COG2814	Major facilitator Superfamily
CRV15_RS27210	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS27220	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRV15_RS27235	COG1335	isochorismatase
CRV15_RS27240	COG0010	Belongs to the arginase family
CRV15_RS27245	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRV15_RS27290	COG0701	Predicted permease
CRV15_RS27300	COG2815	serine threonine protein kinase
CRV15_RS27300	COG0515	serine threonine protein kinase
CRV15_RS27310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRV15_RS27315	COG2070	2-Nitropropane dioxygenase
CRV15_RS27325	COG0387	Pfam Sodium calcium exchanger
CRV15_RS27335	COG2267	carboxylic ester hydrolase activity
CRV15_RS27340	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS27345	COG1024	Enoyl-CoA hydratase
CRV15_RS27405	COG1132	(ABC) transporter
CRV15_RS27405	COG2375	cellular response to nickel ion
CRV15_RS27420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRV15_RS27420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRV15_RS27430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRV15_RS27435	COG0765	amino acid transport
CRV15_RS27440	COG1126	abc transporter atp-binding protein
CRV15_RS27460	COG1957	nucleoside hydrolase
CRV15_RS27470	COG2318	DinB family
CRV15_RS27490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS27495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS27540	COG0501	Belongs to the peptidase M48B family
CRV15_RS27580	COG1404	Belongs to the peptidase S8 family
CRV15_RS27580	COG4412	M6 family metalloprotease domain protein
CRV15_RS27580	COG1404	Belongs to the peptidase S8 family
CRV15_RS27580	COG4412	M6 family metalloprotease domain protein
CRV15_RS27635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRV15_RS27655	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS27690	COG0288	reversible hydration of carbon dioxide
CRV15_RS27700	COG0702	epimerase
CRV15_RS27710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRV15_RS27725	COG2226	methyltransferase
CRV15_RS27740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRV15_RS27745	COG1937	Protein conserved in bacteria
CRV15_RS27775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRV15_RS27835	COG0142	geranyltranstransferase activity
CRV15_RS27845	COG1132	(ABC) transporter
CRV15_RS27855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRV15_RS28055	COG3321	synthase
CRV15_RS28055	COG0604	alcohol dehydrogenase
CRV15_RS28065	COG3321	synthase
CRV15_RS28065	COG0604	alcohol dehydrogenase
CRV15_RS28070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRV15_RS28170	COG4106	trans-aconitate 2-methyltransferase activity
CRV15_RS28215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CRV15_RS28220	COG2079	MmgE PrpD family protein
CRV15_RS28225	COG1396	sequence-specific DNA binding
CRV15_RS28225	COG3800	Transcriptional regulator
CRV15_RS28240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS28240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS28245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRV15_RS28265	COG1404	Belongs to the peptidase S8 family
CRV15_RS28275	COG2409	Drug exporters of the RND superfamily
CRV15_RS28280	COG4585	Histidine kinase
CRV15_RS28285	COG2197	response regulator
CRV15_RS28290	COG0154	amidase activity
CRV15_RS28310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRV15_RS28345	COG2890	protein-(glutamine-N5) methyltransferase activity
CRV15_RS28415	COG1674	ftsk spoiiie
CRV15_RS28420	COG1404	Belongs to the peptidase S8 family
CRV15_RS28425	COG0464	growth
CRV15_RS28460	COG2124	cytochrome p450
CRV15_RS28465	COG3170	Tfp pilus assembly protein FimV
CRV15_RS28580	COG0346	lactoylglutathione lyase activity
CRV15_RS28675	COG1278	Cold shock
CRV15_RS28800	COG0792	nuclease activity
CRV15_RS28870	COG2226	methyltransferase
CRV15_RS28905	COG3629	intracellular signal transduction
CRV15_RS28905	COG3903	Transcriptional regulator
CRV15_RS28920	COG2207	Transcriptional regulator
CRV15_RS29000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRV15_RS29190	COG2267	carboxylic ester hydrolase activity
CRV15_RS29445	COG0328	RNA-DNA hybrid ribonuclease activity
CRV15_RS29455	COG0535	radical SAM domain protein
CRV15_RS29510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CRV15_RS29515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRV15_RS29525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS29530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS29535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS29555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS29565	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS29570	COG0156	8-amino-7-oxononanoate synthase activity
CRV15_RS29580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRV15_RS29610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS29615	COG1132	(ABC) transporter
CRV15_RS29620	COG1132	(ABC) transporter
CRV15_RS29695	COG2124	cytochrome p450
CRV15_RS29820	COG0456	acetyltransferase
CRV15_RS29885	COG4221	oxidoreductase activity
CRV15_RS29895	COG4249	Peptidase C14 caspase catalytic subunit p20
CRV15_RS29895	COG2319	Wd-40 repeat
CRV15_RS29970	COG3634	alkyl hydroperoxide reductase activity
CRV15_RS30045	COG1132	(ABC) transporter
CRV15_RS30070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRV15_RS30145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CRV15_RS30250	COG2124	cytochrome p450
CRV15_RS30280	COG2267	carboxylic ester hydrolase activity
CRV15_RS30295	COG2816	NAD+ diphosphatase activity
CRV15_RS30305	COG1660	Displays ATPase and GTPase activities
CRV15_RS30330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRV15_RS30355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRV15_RS30365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CRV15_RS30375	COG2197	response regulator
CRV15_RS30385	COG0586	Pfam SNARE associated Golgi protein
CRV15_RS30395	COG1136	(ABC) transporter
CRV15_RS30395	COG0577	efflux transmembrane transporter activity
CRV15_RS30440	COG0142	geranyltranstransferase activity
CRV15_RS30455	COG2124	cytochrome p450
CRV15_RS30460	COG1657	PFAM Prenyltransferase squalene oxidase
CRV15_RS30495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRV15_RS30525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRV15_RS30540	COG2409	Drug exporters of the RND superfamily
CRV15_RS30620	COG2319	Wd-40 repeat
CRV15_RS30620	COG4249	Peptidase C14 caspase catalytic subunit p20
CRV15_RS30630	COG0583	DNA-binding transcription factor activity
CRV15_RS30675	COG0142	geranyltranstransferase activity
CRV15_RS30735	COG0531	amino acid
CRV15_RS30760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS30765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS30780	COG2319	Wd-40 repeat
CRV15_RS30780	COG4249	Peptidase C14 caspase catalytic subunit p20
CRV15_RS30800	COG0251	oxidation-reduction process
CRV15_RS30805	COG1733	regulation of RNA biosynthetic process
CRV15_RS30820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS30825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRV15_RS30830	COG0156	8-amino-7-oxononanoate synthase activity
CRV15_RS30855	COG0596	Alpha beta hydrolase
CRV15_RS30875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS30885	COG2124	cytochrome p450
CRV15_RS30905	COG2197	response regulator
CRV15_RS31035	COG0640	Transcriptional regulator
CRV15_RS31050	COG3629	intracellular signal transduction
CRV15_RS31050	COG3903	Transcriptional regulator
CRV15_RS31075	COG0488	(ABC) transporter
CRV15_RS31110	COG1309	transcriptional regulator
CRV15_RS31115	COG0477	Major facilitator Superfamily
CRV15_RS31145	COG1131	(ABC) transporter
CRV15_RS31175	COG0515	serine threonine protein kinase
CRV15_RS31210	COG0484	heat shock protein binding
CRV15_RS31270	COG0640	Transcriptional regulator
CRV15_RS31275	COG2267	carboxylic ester hydrolase activity
CRV15_RS31290	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS31295	COG2124	cytochrome p450
CRV15_RS31355	COG0464	growth
CRV15_RS31375	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS31405	COG0189	ligase activity
CRV15_RS31445	COG2124	cytochrome p450
CRV15_RS31535	COG3959	Transketolase, thiamine diphosphate binding domain
CRV15_RS31540	COG3958	Transketolase
CRV15_RS31575	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CRV15_RS31580	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS31585	COG0277	FAD linked oxidase domain protein
CRV15_RS31590	COG1070	Carbohydrate kinase
CRV15_RS31635	COG2124	cytochrome p450
CRV15_RS31640	COG1011	Hydrolase
CRV15_RS31675	COG0789	Transcriptional regulator
CRV15_RS31685	COG3397	chitin binding
CRV15_RS31715	COG1132	(ABC) transporter
CRV15_RS31775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRV15_RS31780	COG2124	cytochrome p450
CRV15_RS31795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRV15_RS31815	COG3409	Peptidoglycan-binding domain 1 protein
CRV15_RS31815	COG3757	hydrolase, family 25
CRV15_RS31855	COG0488	(ABC) transporter
CRV15_RS31885	COG0698	ribose 5-phosphate isomerase
CRV15_RS31920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS31930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRV15_RS31945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CRV15_RS31955	COG2267	carboxylic ester hydrolase activity
CRV15_RS32035	COG0477	Major facilitator Superfamily
CRV15_RS32080	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS32115	COG2226	methyltransferase
CRV15_RS32130	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CRV15_RS32145	COG3409	Peptidoglycan-binding domain 1 protein
CRV15_RS32190	COG0494	nUDIX hydrolase
CRV15_RS32210	COG3903	Transcriptional regulator
CRV15_RS32210	COG3629	intracellular signal transduction
CRV15_RS32235	COG1725	Transcriptional regulator
CRV15_RS32240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CRV15_RS32250	COG1309	transcriptional regulator
CRV15_RS32275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRV15_RS32330	COG2318	DinB family
CRV15_RS32435	COG2319	Wd-40 repeat
CRV15_RS32435	COG4249	Peptidase C14 caspase catalytic subunit p20
CRV15_RS32465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRV15_RS32470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRV15_RS32485	COG0431	NADPH-dependent FMN reductase
CRV15_RS32495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS32500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS32505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRV15_RS32545	COG0640	Transcriptional regulator
CRV15_RS32575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRV15_RS32585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRV15_RS32590	COG0301	tRNA thio-modification
CRV15_RS32620	COG1024	Enoyl-CoA hydratase
CRV15_RS32665	COG0110	maltose O-acetyltransferase activity
CRV15_RS32715	COG0477	Major facilitator Superfamily
CRV15_RS32755	COG0546	phosphoglycolate phosphatase activity
CRV15_RS32775	COG0363	glucosamine-6-phosphate deaminase activity
CRV15_RS32780	COG1940	carbohydrate kinase activity
CRV15_RS32805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRV15_RS32815	COG4552	Acetyltransferase involved in intracellular survival and related
CRV15_RS32825	COG2816	NAD+ diphosphatase activity
CRV15_RS32835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS32840	COG1228	amidohydrolase
CRV15_RS32905	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CRV15_RS32910	COG1732	Glycine betaine
CRV15_RS32915	COG1174	glycine betaine transport
CRV15_RS32920	COG0517	IMP dehydrogenase activity
CRV15_RS32920	COG1125	glycine betaine transport
CRV15_RS32935	COG0076	glutamate decarboxylase activity
CRV15_RS32955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CRV15_RS32960	COG1121	(ABC) transporter
CRV15_RS33000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRV15_RS33145	COG1320	monovalent cation:proton antiporter activity
CRV15_RS33160	COG0651	ATP synthesis coupled electron transport
CRV15_RS33165	COG1006	Multisubunit Na H antiporter MnhC subunit
CRV15_RS33170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRV15_RS33170	COG2111	Na H antiporter
CRV15_RS33215	COG0583	DNA-binding transcription factor activity
CRV15_RS33230	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRV15_RS33240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRV15_RS33245	COG0436	Aminotransferase
CRV15_RS33270	COG0367	asparagine synthase
CRV15_RS33275	COG0010	Belongs to the arginase family
CRV15_RS33280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CRV15_RS33285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRV15_RS33300	COG2201	protein-glutamate methylesterase activity
CRV15_RS33310	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS33335	COG5183	chlorophyll binding
CRV15_RS33335	COG2133	pyrroloquinoline quinone binding
CRV15_RS33340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRV15_RS33370	COG3973	AAA domain
CRV15_RS33375	COG3409	Peptidoglycan-binding domain 1 protein
CRV15_RS33420	COG1335	isochorismatase
CRV15_RS33425	COG4249	Peptidase C14 caspase catalytic subunit p20
CRV15_RS33425	COG2319	Wd-40 repeat
CRV15_RS33460	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CRV15_RS33490	COG2124	cytochrome p450
CRV15_RS33600	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS33610	COG2124	cytochrome p450
CRV15_RS33645	COG4948	Mandelate Racemase Muconate Lactonizing
CRV15_RS33670	COG2205	protein histidine kinase activity
CRV15_RS33675	COG0745	RESPONSE REGULATOR receiver
CRV15_RS33690	COG0577	efflux transmembrane transporter activity
CRV15_RS33690	COG1136	(ABC) transporter
CRV15_RS33695	COG1136	(ABC) transporter
CRV15_RS33695	COG0577	efflux transmembrane transporter activity
CRV15_RS33745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRV15_RS33755	COG2226	methyltransferase
CRV15_RS33765	COG0640	Transcriptional regulator
CRV15_RS33770	COG0346	lactoylglutathione lyase activity
CRV15_RS33775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRV15_RS33780	COG2124	cytochrome p450
CRV15_RS33785	COG2124	cytochrome p450
CRV15_RS33790	COG1695	Transcriptional regulator
CRV15_RS33800	COG0436	Aminotransferase
CRV15_RS33805	COG0789	Transcriptional regulator
CRV15_RS33835	COG2124	cytochrome p450
CRV15_RS33910	COG3903	Transcriptional regulator
CRV15_RS33910	COG3629	intracellular signal transduction
CRV15_RS33920	COG1222	aaa ATPase
CRV15_RS33930	COG2197	response regulator
CRV15_RS33975	COG2304	oxidoreductase activity
CRV15_RS33990	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CRV15_RS34000	COG0531	amino acid
CRV15_RS34040	COG0076	glutamate decarboxylase activity
CRV15_RS34060	COG2814	Major facilitator Superfamily
CRV15_RS34080	COG0604	alcohol dehydrogenase
CRV15_RS34080	COG3321	synthase
CRV15_RS34120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRV15_RS34135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRV15_RS34140	COG2814	Major facilitator Superfamily
CRV15_RS34165	COG2197	response regulator
CRV15_RS34235	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS34240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRV15_RS34250	COG3547	Transposase (IS116 IS110 IS902 family)
CRV15_RS34295	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS34300	COG0156	8-amino-7-oxononanoate synthase activity
CRV15_RS34305	COG1132	(ABC) transporter
CRV15_RS34315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRV15_RS34335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRV15_RS34345	COG2192	nodulation
CRV15_RS34365	COG1131	(ABC) transporter
CRV15_RS34375	COG1216	Glycosyl transferase, family 2
CRV15_RS34385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CRV15_RS34395	COG0134	indole-3-glycerol-phosphate synthase activity
CRV15_RS34400	COG0135	phosphoribosylanthranilate isomerase activity
CRV15_RS34405	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS34410	COG0662	Cupin 2, conserved barrel domain protein
CRV15_RS34415	COG0159	tryptophan synthase activity
CRV15_RS34420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRV15_RS34430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS34440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS34445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS34475	COG2318	DinB family
CRV15_RS34525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRV15_RS34540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS34545	COG3320	Male sterility
CRV15_RS34545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRV15_RS34550	COG0318	PFAM AMP-dependent synthetase and ligase
CRV15_RS34570	COG0076	glutamate decarboxylase activity
CRV15_RS34595	COG2986	histidine ammonia-lyase
CRV15_RS34625	COG2271	Major facilitator Superfamily
CRV15_RS34670	COG2124	cytochrome p450
CRV15_RS34675	COG2207	Transcriptional regulator
CRV15_RS34705	COG0596	Alpha beta hydrolase
CRV15_RS34710	COG2226	methyltransferase
CRV15_RS34715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRV15_RS34740	COG0477	Major facilitator Superfamily
CRV15_RS34745	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS34750	COG1088	dTDP-glucose 4,6-dehydratase activity
CRV15_RS34770	COG1404	Belongs to the peptidase S8 family
CRV15_RS34780	COG2837	iron assimilation
CRV15_RS34795	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CRV15_RS34795	COG3266	domain, Protein
CRV15_RS34795	COG4932	domain protein
CRV15_RS34850	COG1940	carbohydrate kinase activity
CRV15_RS34870	COG3119	arylsulfatase activity
CRV15_RS34900	COG2132	Multicopper oxidase
CRV15_RS34920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRV15_RS34985	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS35000	COG3119	arylsulfatase activity
CRV15_RS35020	COG2226	methyltransferase
CRV15_RS35020	COG3433	isochorismatase activity
CRV15_RS35020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRV15_RS35070	COG2205	protein histidine kinase activity
CRV15_RS35075	COG0745	RESPONSE REGULATOR receiver
CRV15_RS35080	COG0577	efflux transmembrane transporter activity
CRV15_RS35085	COG1136	(ABC) transporter
CRV15_RS35125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRV15_RS35145	COG0174	glutamine synthetase
CRV15_RS35165	COG2239	Acts as a magnesium transporter
CRV15_RS35170	COG1285	pathogenesis
CRV15_RS35175	COG0531	amino acid
CRV15_RS35180	COG0745	RESPONSE REGULATOR receiver
CRV15_RS35185	COG0642	Histidine kinase
CRV15_RS35190	COG5434	Belongs to the glycosyl hydrolase 28 family
CRV15_RS35220	COG2843	Capsule synthesis protein
CRV15_RS35245	COG0697	spore germination
CRV15_RS35250	COG1045	serine acetyltransferase
CRV15_RS35285	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS35290	COG0513	Belongs to the DEAD box helicase family
CRV15_RS35375	COG1846	Transcriptional regulator
CRV15_RS35405	COG2192	nodulation
CRV15_RS35410	COG2175	clavaminate synthase activity
CRV15_RS35415	COG0297	glycogen (starch) synthase activity
CRV15_RS35580	COG1595	DNA-templated transcription, initiation
CRV15_RS35605	COG0535	radical SAM domain protein
CRV15_RS35640	COG3479	Phenolic acid decarboxylase
CRV15_RS35660	COG1652	LysM domain
CRV15_RS35665	COG0739	heme binding
CRV15_RS35695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRV15_RS35700	COG0640	Transcriptional regulator
CRV15_RS35705	COG1028	Short-chain dehydrogenase reductase Sdr
CRV15_RS35710	COG1959	2 iron, 2 sulfur cluster binding
CRV15_RS35720	COG4221	oxidoreductase activity
CRV15_RS35735	COG1960	acyl-CoA dehydrogenase activity
CRV15_RS35740	COG0583	DNA-binding transcription factor activity
CRV15_RS35755	COG1132	(ABC) transporter
CRV15_RS35760	COG1132	(ABC) transporter
CRV15_RS35770	COG1120	ATPase activity
CRV15_RS35775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRV15_RS35780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily