locus-tag	class	description
GE265_RS00065	COG1250	3-hydroxyacyl-CoA dehydrogenase
GE265_RS00070	COG0604	alcohol dehydrogenase
GE265_RS00070	COG3321	synthase
GE265_RS00080	COG0604	alcohol dehydrogenase
GE265_RS00080	COG3321	synthase
GE265_RS00275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GE265_RS00285	COG1132	(ABC) transporter
GE265_RS00295	COG0142	geranyltranstransferase activity
GE265_RS00360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GE265_RS00390	COG1937	Protein conserved in bacteria
GE265_RS00395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GE265_RS00405	COG2226	methyltransferase
GE265_RS00420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE265_RS00430	COG0702	epimerase
GE265_RS00440	COG0288	reversible hydration of carbon dioxide
GE265_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS00490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GE265_RS00545	COG1404	Belongs to the peptidase S8 family
GE265_RS00545	COG4412	M6 family metalloprotease domain protein
GE265_RS00545	COG1404	Belongs to the peptidase S8 family
GE265_RS00545	COG4412	M6 family metalloprotease domain protein
GE265_RS00585	COG0501	Belongs to the peptidase M48B family
GE265_RS00630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS00635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS00655	COG2318	DinB family
GE265_RS00665	COG1957	nucleoside hydrolase
GE265_RS00685	COG1126	abc transporter atp-binding protein
GE265_RS00690	COG0765	amino acid transport
GE265_RS00695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE265_RS00705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GE265_RS00705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GE265_RS00720	COG2375	cellular response to nickel ion
GE265_RS00720	COG1132	(ABC) transporter
GE265_RS00785	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS00790	COG2267	carboxylic ester hydrolase activity
GE265_RS00795	COG0387	Pfam Sodium calcium exchanger
GE265_RS00805	COG2070	2-Nitropropane dioxygenase
GE265_RS00810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GE265_RS00820	COG0515	serine threonine protein kinase
GE265_RS00820	COG2815	serine threonine protein kinase
GE265_RS00830	COG0701	Predicted permease
GE265_RS00875	COG1181	Belongs to the D-alanine--D-alanine ligase family
GE265_RS00880	COG0010	Belongs to the arginase family
GE265_RS00885	COG1335	isochorismatase
GE265_RS00900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GE265_RS00910	COG1960	acyl-CoA dehydrogenase activity
GE265_RS00950	COG2814	Major facilitator Superfamily
GE265_RS00960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GE265_RS00960	COG1796	DNA polymerase
GE265_RS00970	COG3511	phospholipase C
GE265_RS00990	COG1017	nitric oxide dioxygenase activity
GE265_RS00990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GE265_RS00995	COG1959	2 iron, 2 sulfur cluster binding
GE265_RS01000	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
GE265_RS01035	COG1846	Transcriptional regulator
GE265_RS01090	COG1131	(ABC) transporter
GE265_RS01125	COG2376	Dihydroxyacetone kinase
GE265_RS01130	COG1461	Dihydroxyacetone kinase
GE265_RS01155	COG0363	glucosamine-6-phosphate deaminase activity
GE265_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS01205	COG1486	melibiose metabolic process
GE265_RS01290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GE265_RS01295	COG1215	transferase activity, transferring glycosyl groups
GE265_RS01315	COG1349	DNA-binding transcription factor activity
GE265_RS01325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS01345	COG1940	carbohydrate kinase activity
GE265_RS01360	COG0644	oxidoreductase
GE265_RS01380	COG0395	ABC-type sugar transport system, permease component
GE265_RS01385	COG1175	transmembrane transport
GE265_RS01395	COG3345	alpha-galactosidase
GE265_RS01415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GE265_RS01425	COG0204	Acyl-transferase
GE265_RS01445	COG0584	glycerophosphoryl diester phosphodiesterase
GE265_RS01470	COG0671	phosphoesterase, PA-phosphatase related
GE265_RS01475	COG1309	transcriptional regulator
GE265_RS01500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GE265_RS01515	COG2706	6-phosphogluconolactonase activity
GE265_RS01530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GE265_RS01565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GE265_RS01645	COG0375	protein maturation
GE265_RS01650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GE265_RS01660	COG0298	carbon dioxide binding
GE265_RS01670	COG0309	Hydrogenase expression formation protein (HypE)
GE265_RS01710	COG0326	Molecular chaperone. Has ATPase activity
GE265_RS01715	COG0463	Glycosyl transferase, family 2
GE265_RS01750	COG2205	protein histidine kinase activity
GE265_RS01755	COG0745	RESPONSE REGULATOR receiver
GE265_RS01770	COG0577	efflux transmembrane transporter activity
GE265_RS01770	COG1136	(ABC) transporter
GE265_RS01775	COG1136	(ABC) transporter
GE265_RS01775	COG0577	efflux transmembrane transporter activity
GE265_RS01785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GE265_RS01800	COG1278	Cold shock
GE265_RS01865	COG1674	ftsk spoiiie
GE265_RS01870	COG1404	Belongs to the peptidase S8 family
GE265_RS01875	COG0464	growth
GE265_RS01880	COG4607	ABC-type enterochelin transport system periplasmic component
GE265_RS01905	COG1132	(ABC) transporter
GE265_RS01915	COG1120	ATPase activity
GE265_RS01920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GE265_RS02025	COG1902	pentaerythritol trinitrate reductase activity
GE265_RS02030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS02040	COG1309	transcriptional regulator
GE265_RS02055	COG0443	Heat shock 70 kDa protein
GE265_RS02115	COG2072	flavoprotein involved in K transport
GE265_RS02120	COG1132	(ABC) transporter
GE265_RS02140	COG1960	acyl-CoA dehydrogenase activity
GE265_RS02155	COG0604	alcohol dehydrogenase
GE265_RS02155	COG3321	synthase
GE265_RS02160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GE265_RS02215	COG1013	pyruvate-flavodoxin oxidoreductase activity
GE265_RS02220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GE265_RS02220	COG0674	pyruvate-flavodoxin oxidoreductase activity
GE265_RS02230	COG2409	Drug exporters of the RND superfamily
GE265_RS02250	COG2197	response regulator
GE265_RS02255	COG4585	Histidine kinase
GE265_RS02285	COG0477	Major facilitator Superfamily
GE265_RS02300	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS02310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GE265_RS02320	COG2124	cytochrome p450
GE265_RS02335	COG2409	Drug exporters of the RND superfamily
GE265_RS02345	COG1132	(ABC) transporter
GE265_RS02350	COG1132	(ABC) transporter
GE265_RS02350	COG2375	cellular response to nickel ion
GE265_RS02370	COG1946	Acyl-CoA thioesterase
GE265_RS02375	COG0386	Belongs to the glutathione peroxidase family
GE265_RS02400	COG1960	acyl-CoA dehydrogenase activity
GE265_RS02410	COG0242	peptide deformylase activity
GE265_RS02420	COG3442	glutamine amidotransferase
GE265_RS02425	COG0205	6-phosphofructokinase activity
GE265_RS02445	COG0142	geranyltranstransferase activity
GE265_RS02450	COG0142	geranyltranstransferase activity
GE265_RS02465	COG0204	Acyl-transferase
GE265_RS02475	COG0829	nickel cation binding
GE265_RS02480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GE265_RS02490	COG0804	urea catabolic process
GE265_RS02495	COG0832	Belongs to the urease beta subunit family
GE265_RS02500	COG0831	urea catabolic process
GE265_RS02510	COG0740	serine-type endopeptidase activity
GE265_RS02530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GE265_RS02535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS02540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GE265_RS02575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GE265_RS02585	COG1940	carbohydrate kinase activity
GE265_RS02590	COG2188	Transcriptional regulator
GE265_RS02605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE265_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS02640	COG0419	ATPase involved in DNA repair
GE265_RS02640	COG0419	ATPase involved in DNA repair
GE265_RS02645	COG0420	3'-5' exonuclease activity
GE265_RS02650	COG0666	response to abiotic stimulus
GE265_RS02660	COG1739	Uncharacterized protein family UPF0029
GE265_RS02665	COG1832	CoA-binding protein
GE265_RS02700	COG2124	cytochrome p450
GE265_RS02725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GE265_RS02740	COG1968	undecaprenyl-diphosphatase activity
GE265_RS02755	COG2813	Specifically methylates the guanine in position
GE265_RS02765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GE265_RS02780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GE265_RS02835	COG0697	spore germination
GE265_RS02900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GE265_RS02900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GE265_RS02910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GE265_RS02930	COG1716	ATPase activity
GE265_RS02950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GE265_RS02980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GE265_RS02990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GE265_RS03010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GE265_RS03015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE265_RS03020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GE265_RS03035	COG2018	Roadblock/LC7 domain
GE265_RS03040	COG5002	protein histidine kinase activity
GE265_RS03070	COG2814	Major facilitator Superfamily
GE265_RS03075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GE265_RS03080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GE265_RS03085	COG1984	allophanate hydrolase subunit 2
GE265_RS03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE265_RS03120	COG2364	Membrane
GE265_RS03130	COG2270	Major facilitator Superfamily
GE265_RS03145	COG1216	Glycosyl transferase, family 2
GE265_RS03165	COG1960	acyl-CoA dehydrogenase activity
GE265_RS03170	COG1309	transcriptional regulator
GE265_RS03210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GE265_RS03215	COG0140	phosphoribosyl-ATP diphosphatase activity
GE265_RS03220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GE265_RS03225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GE265_RS03225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GE265_RS03230	COG3201	nicotinamide mononucleotide transporter
GE265_RS03245	COG1846	Transcriptional regulator
GE265_RS03245	COG1940	carbohydrate kinase activity
GE265_RS03250	COG0738	Major facilitator superfamily
GE265_RS03260	COG2233	PERMEase
GE265_RS03275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GE265_RS03285	COG1191	sigma factor activity
GE265_RS03315	COG2390	Transcriptional regulator
GE265_RS03320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GE265_RS03330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GE265_RS03345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GE265_RS03370	COG0284	orotidine-5'-phosphate decarboxylase activity
GE265_RS03375	COG0167	dihydroorotate dehydrogenase activity
GE265_RS03380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GE265_RS03385	COG0505	Belongs to the CarA family
GE265_RS03395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GE265_RS03400	COG0540	Belongs to the ATCase OTCase family
GE265_RS03405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GE265_RS03415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GE265_RS03420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GE265_RS03425	COG0006	proline dipeptidase activity
GE265_RS03435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GE265_RS03440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GE265_RS03445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GE265_RS03450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GE265_RS03455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GE265_RS03460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GE265_RS03465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GE265_RS03470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GE265_RS03485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GE265_RS03505	COG0124	histidyl-tRNA synthetase
GE265_RS03515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GE265_RS03520	COG1196	nuclear chromosome segregation
GE265_RS03530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GE265_RS03535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GE265_RS03540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GE265_RS03545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GE265_RS03555	COG2255	four-way junction helicase activity
GE265_RS03560	COG0632	four-way junction helicase activity
GE265_RS03565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GE265_RS03570	COG0217	transcriptional regulatory protein
GE265_RS03575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GE265_RS03580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GE265_RS03590	COG0438	transferase activity, transferring glycosyl groups
GE265_RS03595	COG1560	Kdo2-lipid A biosynthetic process
GE265_RS03600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GE265_RS03620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GE265_RS03625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GE265_RS03630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GE265_RS03680	COG0456	acetyltransferase
GE265_RS03690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GE265_RS03735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GE265_RS03735	COG1648	precorrin-2 dehydrogenase activity
GE265_RS03740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GE265_RS03755	COG1464	Belongs to the NlpA lipoprotein family
GE265_RS03760	COG2011	ABC-type metal ion transport system permease component
GE265_RS03765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GE265_RS03785	COG0584	glycerophosphoryl diester phosphodiesterase
GE265_RS03790	COG0204	Acyl-transferase
GE265_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS03795	COG0477	Major facilitator Superfamily
GE265_RS03805	COG0165	Argininosuccinate lyase
GE265_RS03810	COG0137	argininosuccinate synthase activity
GE265_RS03815	COG1438	arginine binding
GE265_RS03820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GE265_RS03825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GE265_RS03830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GE265_RS03835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GE265_RS03840	COG2197	response regulator
GE265_RS03845	COG4585	Histidine kinase
GE265_RS03870	COG2838	Isocitrate dehydrogenase
GE265_RS03880	COG0697	spore germination
GE265_RS03890	COG1649	PFAM Uncharacterised BCR, COG1649
GE265_RS03910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GE265_RS03910	COG0072	phenylalanine-tRNA ligase activity
GE265_RS03915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GE265_RS03920	COG5002	protein histidine kinase activity
GE265_RS03925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE265_RS03930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GE265_RS03935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GE265_RS03940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GE265_RS03960	COG1404	Belongs to the peptidase S8 family
GE265_RS03985	COG0174	glutamine synthetase
GE265_RS03990	COG2186	Transcriptional regulator
GE265_RS03995	COG1113	amino acid transport
GE265_RS04000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GE265_RS04020	COG0517	IMP dehydrogenase activity
GE265_RS04020	COG4175	Glycine betaine
GE265_RS04025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE265_RS04060	COG0805	protein transport
GE265_RS04065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GE265_RS04100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GE265_RS04110	COG1609	Transcriptional regulator
GE265_RS04115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GE265_RS04120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GE265_RS04135	COG4122	O-methyltransferase activity
GE265_RS04140	COG1222	aaa ATPase
GE265_RS04160	COG1994	Peptidase M50
GE265_RS04160	COG0517	IMP dehydrogenase activity
GE265_RS04170	COG2197	response regulator
GE265_RS04185	COG0438	transferase activity, transferring glycosyl groups
GE265_RS04190	COG0646	methionine synthase
GE265_RS04190	COG1410	methionine synthase
GE265_RS04195	COG1414	Transcriptional regulator
GE265_RS04200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE265_RS04205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GE265_RS04210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GE265_RS04215	COG2186	Transcriptional regulator
GE265_RS04225	COG1129	ABC transporter
GE265_RS04235	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS04240	COG4948	Mandelate Racemase Muconate Lactonizing
GE265_RS04250	COG0215	cysteine-tRNA ligase activity
GE265_RS04270	COG0598	Magnesium transport protein CorA
GE265_RS04280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS04285	COG0667	Aldo Keto reductase
GE265_RS04315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE265_RS04345	COG1113	amino acid transport
GE265_RS04350	COG2186	Transcriptional regulator
GE265_RS04355	COG3265	gluconokinase activity
GE265_RS04375	COG2149	membrane
GE265_RS04390	COG1960	acyl-CoA dehydrogenase activity
GE265_RS04405	COG3876	Protein conserved in bacteria
GE265_RS04440	COG2851	Citrate transporter
GE265_RS04445	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GE265_RS04450	COG2188	Transcriptional regulator
GE265_RS04455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GE265_RS04465	COG2755	lipolytic protein G-D-S-L family
GE265_RS04475	COG1725	Transcriptional regulator
GE265_RS04500	COG4565	transcriptional regulatory protein
GE265_RS04525	COG0596	Alpha beta hydrolase
GE265_RS04530	COG3903	Transcriptional regulator
GE265_RS04530	COG3629	intracellular signal transduction
GE265_RS04595	COG1799	cell septum assembly
GE265_RS04600	COG1960	acyl-CoA dehydrogenase activity
GE265_RS04605	COG0477	Major facilitator Superfamily
GE265_RS04610	COG0671	phosphoesterase, PA-phosphatase related
GE265_RS04620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GE265_RS04630	COG0438	transferase activity, transferring glycosyl groups
GE265_RS04650	COG1160	GTP binding
GE265_RS04660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GE265_RS04685	COG1051	belongs to the nudix hydrolase family
GE265_RS04685	COG1056	cytidyltransferase-related domain
GE265_RS04690	COG1187	pseudouridine synthase activity
GE265_RS04695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GE265_RS04700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GE265_RS04715	COG0686	Belongs to the AlaDH PNT family
GE265_RS04725	COG0494	nUDIX hydrolase
GE265_RS04730	COG0504	CTP synthase activity
GE265_RS04735	COG3387	PFAM Glycoside hydrolase 15-related
GE265_RS04745	COG0297	glycogen (starch) synthase activity
GE265_RS04750	COG0497	DNA recombination
GE265_RS04755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GE265_RS04775	COG1120	ATPase activity
GE265_RS04780	COG0647	UMP catabolic process
GE265_RS04815	COG2094	Belongs to the DNA glycosylase MPG family
GE265_RS04825	COG1881	PFAM PEBP family protein
GE265_RS04850	COG1119	ATPase activity
GE265_RS04865	COG2197	response regulator
GE265_RS04870	COG4585	Histidine kinase
GE265_RS04880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GE265_RS04890	COG0842	Transport permease protein
GE265_RS04890	COG1716	ATPase activity
GE265_RS04890	COG1131	(ABC) transporter
GE265_RS04895	COG3830	Belongs to the UPF0237 family
GE265_RS04895	COG0560	Phosphoserine phosphatase
GE265_RS04910	COG2807	transmembrane transport
GE265_RS04915	COG2186	Transcriptional regulator
GE265_RS04920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GE265_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS04940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GE265_RS04960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GE265_RS04965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GE265_RS04975	COG1404	Belongs to the peptidase S8 family
GE265_RS05010	COG3387	PFAM Glycoside hydrolase 15-related
GE265_RS05050	COG1024	Enoyl-CoA hydratase
GE265_RS05060	COG0488	(ABC) transporter
GE265_RS05075	COG0235	Class ii aldolase
GE265_RS05090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GE265_RS05095	COG1492	cobalamin metabolic process
GE265_RS05110	COG1797	cobyrinic acid a,c-diamide synthase activity
GE265_RS05140	COG0134	indole-3-glycerol-phosphate synthase activity
GE265_RS05155	COG1917	Cupin 2, conserved barrel domain protein
GE265_RS05160	COG5285	phytanoyl-CoA dioxygenase
GE265_RS05165	COG1902	pentaerythritol trinitrate reductase activity
GE265_RS05190	COG1414	Transcriptional regulator
GE265_RS05195	COG4585	Histidine kinase
GE265_RS05200	COG2197	response regulator
GE265_RS05205	COG0768	penicillin binding
GE265_RS05215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE265_RS05225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE265_RS05230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GE265_RS05245	COG1802	Transcriptional regulator
GE265_RS05260	COG0745	RESPONSE REGULATOR receiver
GE265_RS05265	COG2205	protein histidine kinase activity
GE265_RS05315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE265_RS05325	COG2171	N-acyltransferase activity
GE265_RS05330	COG2151	metal-sulfur cluster biosynthetic enzyme
GE265_RS05335	COG0822	iron-sulfur transferase activity
GE265_RS05340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE265_RS05345	COG0396	ATPase activity
GE265_RS05355	COG0719	Fe-S assembly protein
GE265_RS05370	COG1131	(ABC) transporter
GE265_RS05400	COG0109	protoheme IX farnesyltransferase activity
GE265_RS05410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GE265_RS05425	COG0363	glucosamine-6-phosphate deaminase activity
GE265_RS05435	COG3402	PFAM membrane-flanked domain
GE265_RS05440	COG0166	Belongs to the GPI family
GE265_RS05450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GE265_RS05455	COG0149	triose-phosphate isomerase activity
GE265_RS05460	COG0126	phosphoglycerate kinase activity
GE265_RS05465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GE265_RS05475	COG1481	regulation of sporulation
GE265_RS05480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GE265_RS05485	COG1660	Displays ATPase and GTPase activities
GE265_RS05490	COG0322	excinuclease ABC activity
GE265_RS05515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GE265_RS05515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GE265_RS05520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GE265_RS05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GE265_RS05550	COG0556	nucleotide-excision repair
GE265_RS05560	COG0584	glycerophosphoryl diester phosphodiesterase
GE265_RS05565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GE265_RS05575	COG2313	pseudouridylate synthase activity
GE265_RS05605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GE265_RS05610	COG0330	HflC and HflK could
GE265_RS05630	COG0237	dephospho-CoA kinase activity
GE265_RS05640	COG0539	negative regulation of cytoplasmic translation
GE265_RS05645	COG2226	methyltransferase
GE265_RS05645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GE265_RS05645	COG0596	Alpha beta hydrolase
GE265_RS05650	COG1643	Atp-dependent helicase
GE265_RS05680	COG2050	protein possibly involved in aromatic compounds catabolism
GE265_RS05700	COG0411	ABC transporter
GE265_RS05750	COG0287	Prephenate dehydrogenase
GE265_RS05750	COG1605	Chorismate mutase
GE265_RS05765	COG0366	Alpha amylase catalytic
GE265_RS05765	COG1470	cell adhesion involved in biofilm formation
GE265_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS05790	COG1024	Enoyl-CoA hydratase
GE265_RS05820	COG0183	Belongs to the thiolase family
GE265_RS05825	COG1309	transcriptional regulator
GE265_RS05835	COG1960	acyl-CoA dehydrogenase activity
GE265_RS05860	COG0070	glutamate synthase
GE265_RS05860	COG0069	glutamate synthase activity
GE265_RS05860	COG0067	glutamate synthase
GE265_RS05895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE265_RS05900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GE265_RS05905	COG2301	Belongs to the HpcH HpaI aldolase family
GE265_RS05910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GE265_RS05920	COG0159	tryptophan synthase activity
GE265_RS05925	COG0133	tryptophan synthase activity
GE265_RS05935	COG0134	indole-3-glycerol-phosphate synthase activity
GE265_RS05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GE265_RS05960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GE265_RS05975	COG0107	imidazoleglycerol-phosphate synthase activity
GE265_RS05980	COG0251	oxidation-reduction process
GE265_RS05985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GE265_RS05990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GE265_RS06000	COG0131	Imidazoleglycerol-phosphate dehydratase
GE265_RS06005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GE265_RS06010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GE265_RS06030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GE265_RS06050	COG1432	Conserved Protein
GE265_RS06060	COG0587	DNA-directed DNA polymerase activity
GE265_RS06110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GE265_RS06125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GE265_RS06130	COG3599	regulation of cell shape
GE265_RS06140	COG1799	cell septum assembly
GE265_RS06150	COG1496	oxidoreductase activity
GE265_RS06160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GE265_RS06165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GE265_RS06175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GE265_RS06180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GE265_RS06185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GE265_RS06190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GE265_RS06195	COG0768	penicillin binding
GE265_RS06205	COG0275	rRNA processing
GE265_RS06215	COG0714	Associated with various cellular activities
GE265_RS06245	COG1121	(ABC) transporter
GE265_RS06250	COG1511	domain protein
GE265_RS06255	COG1309	transcriptional regulator
GE265_RS06265	COG1233	COG1233 Phytoene dehydrogenase and related
GE265_RS06280	COG0352	thiamine-phosphate diphosphorylase activity
GE265_RS06290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GE265_RS06300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE265_RS06300	COG2022	thiamine diphosphate biosynthetic process
GE265_RS06310	COG2022	thiamine diphosphate biosynthetic process
GE265_RS06315	COG0515	serine threonine protein kinase
GE265_RS06315	COG2815	serine threonine protein kinase
GE265_RS06320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GE265_RS06325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GE265_RS06330	COG2193	ferroxidase activity
GE265_RS06335	COG0243	molybdopterin cofactor binding
GE265_RS06340	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GE265_RS06350	COG0205	6-phosphofructokinase activity
GE265_RS06355	COG2197	response regulator
GE265_RS06385	COG1940	carbohydrate kinase activity
GE265_RS06395	COG0003	Pfam Anion-transporting ATPase
GE265_RS06420	COG0438	transferase activity, transferring glycosyl groups
GE265_RS06470	COG2205	protein histidine kinase activity
GE265_RS06475	COG0745	RESPONSE REGULATOR receiver
GE265_RS06485	COG1929	Belongs to the glycerate kinase type-1 family
GE265_RS06490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE265_RS06495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GE265_RS06500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GE265_RS06505	COG0723	plastoquinol--plastocyanin reductase activity
GE265_RS06510	COG2010	Cytochrome c
GE265_RS06515	COG1845	cytochrome c oxidase, subunit III
GE265_RS06525	COG1376	ErfK ybiS ycfS ynhG family protein
GE265_RS06535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GE265_RS06540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GE265_RS06550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE265_RS06570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GE265_RS06580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GE265_RS06585	COG2197	response regulator
GE265_RS06590	COG4585	Histidine kinase
GE265_RS06615	COG1132	(ABC) transporter
GE265_RS06620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GE265_RS06650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GE265_RS06660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GE265_RS06665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GE265_RS06670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GE265_RS06675	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE265_RS06685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GE265_RS06715	COG1090	epimerase
GE265_RS06730	COG0321	lipoyl(octanoyl) transferase activity
GE265_RS06735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GE265_RS06785	COG0181	hydroxymethylbilane synthase activity
GE265_RS06810	COG0673	inositol 2-dehydrogenase activity
GE265_RS06820	COG0745	RESPONSE REGULATOR receiver
GE265_RS06860	COG2197	response regulator
GE265_RS06890	COG1175	transmembrane transport
GE265_RS06895	COG3833	ABC-type maltose transport systems, permease component
GE265_RS06900	COG0366	Alpha amylase catalytic
GE265_RS06905	COG1609	Transcriptional regulator
GE265_RS06925	COG2154	pterin-4-alpha-carbinolamine dehydratase
GE265_RS06940	COG0494	nUDIX hydrolase
GE265_RS06945	COG2154	pterin-4-alpha-carbinolamine dehydratase
GE265_RS06970	COG1228	amidohydrolase
GE265_RS06985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GE265_RS07000	COG0174	glutamine synthetase
GE265_RS07035	COG2132	Multicopper oxidase
GE265_RS07040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GE265_RS07040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GE265_RS07050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GE265_RS07070	COG1994	Peptidase M50
GE265_RS07105	COG5398	heme oxygenase
GE265_RS07130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS07135	COG1120	ATPase activity
GE265_RS07155	COG1834	amidinotransferase
GE265_RS07170	COG2814	Major facilitator Superfamily
GE265_RS07175	COG3540	Alkaline phosphatase
GE265_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS07225	COG0395	ABC-type sugar transport system, permease component
GE265_RS07235	COG1653	transport
GE265_RS07240	COG1349	DNA-binding transcription factor activity
GE265_RS07260	COG0789	Transcriptional regulator
GE265_RS07275	COG3022	response to hydroperoxide
GE265_RS07280	COG0800	Aldolase
GE265_RS07300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GE265_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS07320	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GE265_RS07325	COG2030	dehydratase
GE265_RS07340	COG0183	Belongs to the thiolase family
GE265_RS07360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS07370	COG2226	methyltransferase
GE265_RS07375	COG0438	transferase activity, transferring glycosyl groups
GE265_RS07380	COG1309	transcriptional regulator
GE265_RS07415	COG3845	ABC transporter
GE265_RS07430	COG0183	Belongs to the thiolase family
GE265_RS07435	COG2124	cytochrome p450
GE265_RS07445	COG4122	O-methyltransferase activity
GE265_RS07555	COG0582	viral genome integration into host DNA
GE265_RS07580	COG0586	Pfam SNARE associated Golgi protein
GE265_RS07590	COG1358	cellular component organization or biogenesis
GE265_RS07635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GE265_RS07640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS07660	COG4585	Histidine kinase
GE265_RS07665	COG2197	response regulator
GE265_RS07670	COG0667	Aldo Keto reductase
GE265_RS07675	COG0789	Transcriptional regulator
GE265_RS07700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GE265_RS07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS07710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GE265_RS07745	COG2130	NADP-dependent
GE265_RS07800	COG1136	(ABC) transporter
GE265_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS07870	COG1129	ABC transporter
GE265_RS07870	COG0842	Transport permease protein
GE265_RS07905	COG1070	Carbohydrate kinase
GE265_RS07920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GE265_RS07925	COG0358	DNA primase activity
GE265_RS07935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GE265_RS07940	COG2949	membrane
GE265_RS07960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GE265_RS07980	COG2890	protein-(glutamine-N5) methyltransferase activity
GE265_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS07995	COG0531	amino acid
GE265_RS08010	COG0574	Belongs to the PEP-utilizing enzyme family
GE265_RS08010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GE265_RS08050	COG0423	glycine-tRNA ligase activity
GE265_RS08055	COG3443	Belongs to the bacterial solute-binding protein 9 family
GE265_RS08055	COG0803	Belongs to the bacterial solute-binding protein 9 family
GE265_RS08060	COG3842	ATPase activity
GE265_RS08065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GE265_RS08075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GE265_RS08080	COG1381	Involved in DNA repair and RecF pathway recombination
GE265_RS08095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GE265_RS08110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GE265_RS08150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GE265_RS08160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE265_RS08165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GE265_RS08170	COG1234	tRNA 3'-trailer cleavage
GE265_RS08175	COG0537	adenosine 5'-monophosphoramidase activity
GE265_RS08180	COG0793	Belongs to the peptidase S41A family
GE265_RS08180	COG4946	Tricorn protease homolog
GE265_RS08200	COG0484	heat shock protein binding
GE265_RS08205	COG1420	regulation of RNA biosynthetic process
GE265_RS08230	COG0481	GTPase activity
GE265_RS08235	COG0268	Binds directly to 16S ribosomal RNA
GE265_RS08270	COG1307	EDD domain protein, DegV family
GE265_RS08280	COG0495	leucyl-tRNA aminoacylation
GE265_RS08300	COG0588	phosphoglycerate mutase activity
GE265_RS08305	COG0799	negative regulation of ribosome biogenesis
GE265_RS08315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GE265_RS08325	COG0501	Belongs to the peptidase M48B family
GE265_RS08340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GE265_RS08350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GE265_RS08365	COG0438	transferase activity, transferring glycosyl groups
GE265_RS08370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GE265_RS08375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GE265_RS08380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GE265_RS08390	COG1530	ribonuclease E activity
GE265_RS08410	COG0772	Belongs to the SEDS family
GE265_RS08430	COG1077	Cell shape determining protein MreB Mrl
GE265_RS08435	COG0105	UTP biosynthetic process
GE265_RS08445	COG0285	dihydrofolate synthase activity
GE265_RS08450	COG4585	Histidine kinase
GE265_RS08455	COG0525	valine-tRNA ligase activity
GE265_RS08465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GE265_RS08470	COG0740	serine-type endopeptidase activity
GE265_RS08475	COG0740	serine-type endopeptidase activity
GE265_RS08480	COG0544	peptidyl-prolyl cis-trans isomerase activity
GE265_RS08500	COG3594	Acyltransferase
GE265_RS08505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GE265_RS08520	COG0475	glutathione-regulated potassium exporter activity
GE265_RS08535	COG4552	Acetyltransferase involved in intracellular survival and related
GE265_RS08550	COG1113	amino acid transport
GE265_RS08560	COG1113	amino acid transport
GE265_RS08565	COG0588	phosphoglycerate mutase activity
GE265_RS08575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GE265_RS08585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GE265_RS08590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GE265_RS08660	COG0668	transmembrane transport
GE265_RS08680	COG1175	transmembrane transport
GE265_RS08685	COG0395	ABC-type sugar transport system, permease component
GE265_RS08690	COG1486	melibiose metabolic process
GE265_RS08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE265_RS08750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE265_RS08780	COG0629	single-stranded DNA binding
GE265_RS08820	COG1203	CRISPR-associated helicase, Cas3
GE265_RS08830	COG1518	maintenance of DNA repeat elements
GE265_RS08835	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GE265_RS08845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GE265_RS08875	COG0475	glutathione-regulated potassium exporter activity
GE265_RS08885	COG0561	phosphatase activity
GE265_RS08915	COG0494	nUDIX hydrolase
GE265_RS08925	COG2954	triphosphatase activity
GE265_RS08935	COG2197	response regulator
GE265_RS08940	COG0105	UTP biosynthetic process
GE265_RS09000	COG1131	(ABC) transporter
GE265_RS09020	COG3962	Belongs to the TPP enzyme family
GE265_RS09025	COG3718	enzyme involved in inositol metabolism
GE265_RS09035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE265_RS09060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GE265_RS09070	COG1595	DNA-templated transcription, initiation
GE265_RS09085	COG0673	inositol 2-dehydrogenase activity
GE265_RS09090	COG1609	Transcriptional regulator
GE265_RS09105	COG1472	Belongs to the glycosyl hydrolase 3 family
GE265_RS09170	COG1674	ftsk spoiiie
GE265_RS09190	COG3960	tartronate-semialdehyde synthase activity
GE265_RS09200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GE265_RS09215	COG1946	Acyl-CoA thioesterase
GE265_RS09220	COG2124	cytochrome p450
GE265_RS09230	COG1309	transcriptional regulator
GE265_RS09235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GE265_RS09250	COG1960	acyl-CoA dehydrogenase activity
GE265_RS09260	COG0076	glutamate decarboxylase activity
GE265_RS09265	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GE265_RS09290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GE265_RS09295	COG0589	response to stress
GE265_RS09305	COG4977	sequence-specific DNA binding
GE265_RS09310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GE265_RS09325	COG0745	RESPONSE REGULATOR receiver
GE265_RS09365	COG0406	alpha-ribazole phosphatase activity
GE265_RS09400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS09410	COG0154	amidase activity
GE265_RS09420	COG0765	amino acid transport
GE265_RS09425	COG0765	amino acid transport
GE265_RS09430	COG1126	abc transporter atp-binding protein
GE265_RS09500	COG0673	inositol 2-dehydrogenase activity
GE265_RS09510	COG0706	membrane insertase activity
GE265_RS09540	COG2733	membrane
GE265_RS09565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE265_RS09575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GE265_RS09605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GE265_RS09615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GE265_RS09620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE265_RS09625	COG1263	PTS System
GE265_RS09630	COG1263	PTS System
GE265_RS09635	COG1234	tRNA 3'-trailer cleavage
GE265_RS09650	COG1120	ATPase activity
GE265_RS09655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS09660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GE265_RS09670	COG1113	amino acid transport
GE265_RS09680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GE265_RS09690	COG1335	isochorismatase
GE265_RS09730	COG0277	FAD linked oxidase domain protein
GE265_RS09750	COG5002	protein histidine kinase activity
GE265_RS09755	COG0745	RESPONSE REGULATOR receiver
GE265_RS09760	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GE265_RS09785	COG3654	unkown
GE265_RS09825	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GE265_RS09830	COG0395	ABC-type sugar transport system, permease component
GE265_RS09835	COG1175	transmembrane transport
GE265_RS09850	COG1678	Uncharacterized ACR, COG1678
GE265_RS09855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GE265_RS09860	COG0776	regulation of translation
GE265_RS09870	COG3973	AAA domain
GE265_RS09895	COG0583	DNA-binding transcription factor activity
GE265_RS09910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GE265_RS09915	COG0793	Belongs to the peptidase S41A family
GE265_RS09925	COG2884	Cell division ATP-binding protein ftsE
GE265_RS09935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GE265_RS09940	COG0515	serine threonine protein kinase
GE265_RS09945	COG0515	serine threonine protein kinase
GE265_RS09960	COG1175	transmembrane transport
GE265_RS09965	COG0395	ABC-type sugar transport system, permease component
GE265_RS09975	COG2902	Dehydrogenase
GE265_RS10000	COG0653	protein targeting
GE265_RS10010	COG3214	Protein conserved in bacteria
GE265_RS10015	COG2197	response regulator
GE265_RS10020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GE265_RS10030	COG0823	Involved in the tonB-independent uptake of proteins
GE265_RS10035	COG5002	protein histidine kinase activity
GE265_RS10035	COG5000	phosphorelay sensor kinase activity
GE265_RS10040	COG0745	RESPONSE REGULATOR receiver
GE265_RS10045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GE265_RS10055	COG2826	transposase and inactivated derivatives, IS30 family
GE265_RS10080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GE265_RS10090	COG1482	cell wall glycoprotein biosynthetic process
GE265_RS10100	COG2835	tetraacyldisaccharide 4'-kinase activity
GE265_RS10105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE265_RS10140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GE265_RS10145	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GE265_RS10145	COG0778	Nitroreductase
GE265_RS10170	COG1316	TRANSCRIPTIONal
GE265_RS10190	COG1316	TRANSCRIPTIONal
GE265_RS10195	COG1607	acyl-coa hydrolase
GE265_RS10200	COG1316	TRANSCRIPTIONal
GE265_RS10205	COG0596	Alpha beta hydrolase
GE265_RS10210	COG1309	transcriptional regulator
GE265_RS10295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GE265_RS10330	COG2205	protein histidine kinase activity
GE265_RS10335	COG0745	RESPONSE REGULATOR receiver
GE265_RS10340	COG3104	oligopeptide transport
GE265_RS10365	COG1191	sigma factor activity
GE265_RS10390	COG1228	amidohydrolase
GE265_RS10420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GE265_RS10480	COG1737	Transcriptional regulator
GE265_RS10495	COG2755	lipolytic protein G-D-S-L family
GE265_RS10500	COG0183	Belongs to the thiolase family
GE265_RS10530	COG1136	(ABC) transporter
GE265_RS10530	COG0577	efflux transmembrane transporter activity
GE265_RS10535	COG0577	efflux transmembrane transporter activity
GE265_RS10535	COG1136	(ABC) transporter
GE265_RS10540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GE265_RS10545	COG1252	NADH dehydrogenase
GE265_RS10565	COG0148	phosphopyruvate hydratase activity
GE265_RS10575	COG1652	LysM domain
GE265_RS10605	COG0515	serine threonine protein kinase
GE265_RS10605	COG2815	serine threonine protein kinase
GE265_RS10630	COG1595	DNA-templated transcription, initiation
GE265_RS10640	COG0577	efflux transmembrane transporter activity
GE265_RS10645	COG1136	(ABC) transporter
GE265_RS10660	COG0477	Major facilitator Superfamily
GE265_RS10690	COG4585	Histidine kinase
GE265_RS10700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GE265_RS10705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GE265_RS10710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GE265_RS10715	COG0193	aminoacyl-tRNA hydrolase activity
GE265_RS10725	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GE265_RS10735	COG1309	transcriptional regulator
GE265_RS10740	COG4106	trans-aconitate 2-methyltransferase activity
GE265_RS10750	COG2197	response regulator
GE265_RS10755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GE265_RS10785	COG0488	(ABC) transporter
GE265_RS10810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GE265_RS10815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GE265_RS10825	COG0084	hydrolase, TatD family'
GE265_RS10855	COG0442	prolyl-tRNA aminoacylation
GE265_RS10880	COG3409	Peptidoglycan-binding domain 1 protein
GE265_RS10905	COG0124	histidyl-tRNA synthetase
GE265_RS10945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GE265_RS10950	COG1122	ATPase activity
GE265_RS10960	COG0310	cobalt ion transport
GE265_RS10970	COG2409	Drug exporters of the RND superfamily
GE265_RS10980	COG0793	Belongs to the peptidase S41A family
GE265_RS10980	COG4946	Tricorn protease homolog
GE265_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS10990	COG2267	carboxylic ester hydrolase activity
GE265_RS10995	COG2072	flavoprotein involved in K transport
GE265_RS11040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE265_RS11045	COG0315	cyclic pyranopterin monophosphate synthase activity
GE265_RS11045	COG0521	Mo-molybdopterin cofactor biosynthetic process
GE265_RS11050	COG0315	cyclic pyranopterin monophosphate synthase activity
GE265_RS11060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GE265_RS11065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GE265_RS11090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GE265_RS11100	COG1970	mechanosensitive ion channel activity
GE265_RS11115	COG3191	aminopeptidase activity
GE265_RS11125	COG0477	Major facilitator Superfamily
GE265_RS11145	COG3384	dioxygenase
GE265_RS11150	COG1846	Transcriptional regulator
GE265_RS11175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GE265_RS11175	COG1648	precorrin-2 dehydrogenase activity
GE265_RS11180	COG0181	hydroxymethylbilane synthase activity
GE265_RS11185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GE265_RS11190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GE265_RS11205	COG1595	DNA-templated transcription, initiation
GE265_RS11240	COG0123	including yeast histone deacetylase and acetoin utilization protein
GE265_RS11265	COG0180	Tryptophanyl-tRNA synthetase
GE265_RS11270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GE265_RS11275	COG1252	NADH dehydrogenase
GE265_RS11280	COG1595	DNA-templated transcription, initiation
GE265_RS11285	COG2226	methyltransferase
GE265_RS11305	COG0129	dihydroxy-acid dehydratase activity
GE265_RS11315	COG0248	Ppx GppA phosphatase
GE265_RS11335	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GE265_RS11345	COG0671	phosphoesterase, PA-phosphatase related
GE265_RS11350	COG1194	a g-specific adenine glycosylase
GE265_RS11355	COG1595	DNA-templated transcription, initiation
GE265_RS11365	COG0745	RESPONSE REGULATOR receiver
GE265_RS11370	COG2205	protein histidine kinase activity
GE265_RS11375	COG0739	heme binding
GE265_RS11385	COG2027	D-alanyl-D-alanine carboxypeptidase
GE265_RS11400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GE265_RS11420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GE265_RS11430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GE265_RS11435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GE265_RS11450	COG2197	response regulator
GE265_RS11465	COG0649	NAD binding
GE265_RS11480	COG1174	glycine betaine transport
GE265_RS11505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GE265_RS11520	COG0302	gtp cyclohydrolase
GE265_RS11535	COG0037	tRNA processing
GE265_RS11545	COG2027	D-alanyl-D-alanine carboxypeptidase
GE265_RS11550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GE265_RS11565	COG0076	glutamate decarboxylase activity
GE265_RS11580	COG2318	DinB family
GE265_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS11625	COG0110	maltose O-acetyltransferase activity
GE265_RS11630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE265_RS11630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE265_RS11635	COG1132	(ABC) transporter
GE265_RS11745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GE265_RS11905	COG0305	Participates in initiation and elongation during chromosome replication
GE265_RS11985	COG0791	NLP P60 protein
GE265_RS12030	COG1061	Type III restriction enzyme res subunit
GE265_RS12070	COG0477	Major facilitator Superfamily
GE265_RS12080	COG0470	DNA polymerase III
GE265_RS12085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GE265_RS12090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GE265_RS12090	COG1754	DNA topoisomerase type I activity
GE265_RS12100	COG2890	protein-(glutamine-N5) methyltransferase activity
GE265_RS12110	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GE265_RS12115	COG2172	sigma factor antagonist activity
GE265_RS12120	COG1366	Belongs to the anti-sigma-factor antagonist family
GE265_RS12125	COG1205	dead DEAH box helicase
GE265_RS12125	COG1111	helicase
GE265_RS12185	COG0659	secondary active sulfate transmembrane transporter activity
GE265_RS12190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GE265_RS12195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GE265_RS12205	COG2267	carboxylic ester hydrolase activity
GE265_RS12235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GE265_RS12265	COG0003	Pfam Anion-transporting ATPase
GE265_RS12275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE265_RS12280	COG1610	YqeY-like protein
GE265_RS12285	COG1408	metallophosphoesterase
GE265_RS12305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GE265_RS12390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GE265_RS12420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GE265_RS12435	COG2091	lysine biosynthetic process via aminoadipic acid
GE265_RS12450	COG2124	cytochrome p450
GE265_RS12475	COG1595	DNA-templated transcription, initiation
GE265_RS12480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GE265_RS12495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GE265_RS12500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GE265_RS12515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GE265_RS12550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS12555	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS12555	COG2319	Wd-40 repeat
GE265_RS12570	COG1802	Transcriptional regulator
GE265_RS12575	COG0463	Glycosyl transferase, family 2
GE265_RS12605	COG2124	cytochrome p450
GE265_RS12615	COG4585	Histidine kinase
GE265_RS12650	COG0477	Major facilitator Superfamily
GE265_RS12655	COG0191	fructose-bisphosphate aldolase activity
GE265_RS12660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GE265_RS12675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GE265_RS12705	COG0542	response to heat
GE265_RS12725	COG0789	Transcriptional regulator
GE265_RS12730	COG0484	heat shock protein binding
GE265_RS12735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GE265_RS12740	COG0443	Heat shock 70 kDa protein
GE265_RS12745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GE265_RS12750	COG2181	nitrate reductase activity
GE265_RS12750	COG0247	lactate metabolic process
GE265_RS12765	COG0717	Belongs to the dCTP deaminase family
GE265_RS12815	COG0588	phosphoglycerate mutase activity
GE265_RS12820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GE265_RS12830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GE265_RS12855	COG2409	Drug exporters of the RND superfamily
GE265_RS12860	COG4585	Histidine kinase
GE265_RS12865	COG2197	response regulator
GE265_RS12880	COG4171	peptide transport system, permease
GE265_RS12885	COG0601	transmembrane transport
GE265_RS12890	COG4166	transmembrane transport
GE265_RS12905	COG0019	diaminopimelate decarboxylase activity
GE265_RS12910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS12915	COG0534	Mate efflux family protein
GE265_RS12925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GE265_RS12975	COG3903	Transcriptional regulator
GE265_RS12975	COG3629	intracellular signal transduction
GE265_RS13000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS13060	COG0577	efflux transmembrane transporter activity
GE265_RS13070	COG2197	response regulator
GE265_RS13085	COG0436	Aminotransferase
GE265_RS13105	COG1857	crispr-associated protein
GE265_RS13210	COG2826	transposase and inactivated derivatives, IS30 family
GE265_RS13250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS13255	COG2226	methyltransferase
GE265_RS13265	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GE265_RS13345	COG3345	alpha-galactosidase
GE265_RS13350	COG0598	Magnesium transport protein CorA
GE265_RS13380	COG0431	NADPH-dependent FMN reductase
GE265_RS13385	COG1672	PFAM Archaeal ATPase
GE265_RS13385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GE265_RS13410	COG0431	NADPH-dependent FMN reductase
GE265_RS13430	COG0477	Major facilitator Superfamily
GE265_RS13435	COG0745	RESPONSE REGULATOR receiver
GE265_RS13465	COG0784	Response regulator, receiver
GE265_RS13470	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS13475	COG1595	DNA-templated transcription, initiation
GE265_RS13500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GE265_RS13505	COG0587	DNA-directed DNA polymerase activity
GE265_RS13535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GE265_RS13565	COG0006	proline dipeptidase activity
GE265_RS13585	COG1999	signal sequence binding
GE265_RS13600	COG2837	iron assimilation
GE265_RS13605	COG0077	Prephenate dehydratase
GE265_RS13610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GE265_RS13615	COG0561	phosphatase activity
GE265_RS13650	COG1131	(ABC) transporter
GE265_RS13660	COG0561	phosphatase activity
GE265_RS13670	COG4988	ABC transporter
GE265_RS13675	COG1294	oxidase, subunit
GE265_RS13680	COG1271	oxidase subunit
GE265_RS13685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GE265_RS13690	COG1609	Transcriptional regulator
GE265_RS13705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GE265_RS13725	COG0662	Cupin 2, conserved barrel domain protein
GE265_RS13730	COG1950	PFAM Membrane protein of
GE265_RS13735	COG0626	cystathionine gamma-synthase activity
GE265_RS13770	COG0305	Participates in initiation and elongation during chromosome replication
GE265_RS13780	COG0359	binds to the 23S rRNA
GE265_RS13785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GE265_RS13790	COG0629	single-stranded DNA binding
GE265_RS13795	COG0360	Binds together with S18 to 16S ribosomal RNA
GE265_RS13820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE265_RS13840	COG0617	tRNA 3'-terminal CCA addition
GE265_RS13855	COG2815	serine threonine protein kinase
GE265_RS13855	COG0515	serine threonine protein kinase
GE265_RS13860	COG1595	DNA-templated transcription, initiation
GE265_RS13870	COG0492	ferredoxin-NADP+ reductase activity
GE265_RS13875	COG3118	belongs to the thioredoxin family
GE265_RS13890	COG1192	Involved in chromosome partitioning
GE265_RS13895	COG0357	Ribosomal RNA small subunit methyltransferase G
GE265_RS13905	COG0706	membrane insertase activity
GE265_RS13910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GE265_RS13915	COG0594	ribonuclease P activity
GE265_RS13920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GE265_RS13930	COG0592	DNA-directed DNA polymerase activity
GE265_RS13935	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GE265_RS13940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GE265_RS13945	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GE265_RS13955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GE265_RS13975	COG0515	serine threonine protein kinase
GE265_RS13990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS13995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS14000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GE265_RS14005	COG2175	clavaminate synthase activity
GE265_RS14010	COG0667	Aldo Keto reductase
GE265_RS14025	COG1672	PFAM Archaeal ATPase
GE265_RS14025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GE265_RS14030	COG1280	lysine exporter protein (LysE YggA)
GE265_RS14035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE265_RS14040	COG1446	asparaginase
GE265_RS14070	COG0705	Rhomboid family
GE265_RS14070	COG0457	Tetratricopeptide repeat
GE265_RS14085	COG3764	Sortase (surface protein transpeptidase)
GE265_RS14100	COG3764	Sortase (surface protein transpeptidase)
GE265_RS14105	COG3764	Sortase (surface protein transpeptidase)
GE265_RS14110	COG0515	serine threonine protein kinase
GE265_RS14115	COG0768	penicillin binding
GE265_RS14130	COG1716	ATPase activity
GE265_RS14135	COG1716	ATPase activity
GE265_RS14145	COG0577	efflux transmembrane transporter activity
GE265_RS14145	COG1136	(ABC) transporter
GE265_RS14150	COG0577	efflux transmembrane transporter activity
GE265_RS14150	COG1136	(ABC) transporter
GE265_RS14175	COG4585	Histidine kinase
GE265_RS14180	COG2197	response regulator
GE265_RS14195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GE265_RS14200	COG1960	acyl-CoA dehydrogenase activity
GE265_RS14205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GE265_RS14210	COG2151	metal-sulfur cluster biosynthetic enzyme
GE265_RS14215	COG3396	Phenylacetate-CoA oxygenase
GE265_RS14220	COG3460	Phenylacetate-CoA oxygenase
GE265_RS14225	COG3396	Phenylacetate-CoA oxygenase
GE265_RS14250	COG1250	3-hydroxyacyl-CoA dehydrogenase
GE265_RS14255	COG1309	transcriptional regulator
GE265_RS14260	COG1522	sequence-specific DNA binding
GE265_RS14285	COG0303	'Molybdopterin
GE265_RS14315	COG4591	ABC-type transport system involved in lipoprotein release permease component
GE265_RS14315	COG1136	(ABC) transporter
GE265_RS14330	COG0515	serine threonine protein kinase
GE265_RS14335	COG0515	serine threonine protein kinase
GE265_RS14360	COG0022	dehydrogenase e1 component
GE265_RS14365	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE265_RS14380	COG2271	Major facilitator Superfamily
GE265_RS14400	COG1362	aminopeptidase activity
GE265_RS14410	COG1960	acyl-CoA dehydrogenase activity
GE265_RS14435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GE265_RS14455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GE265_RS14460	COG0745	RESPONSE REGULATOR receiver
GE265_RS14465	COG2205	protein histidine kinase activity
GE265_RS14470	COG2304	oxidoreductase activity
GE265_RS14520	COG1191	sigma factor activity
GE265_RS14525	COG1191	sigma factor activity
GE265_RS14570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GE265_RS14585	COG0433	COG0433 Predicted ATPase
GE265_RS14590	COG2234	aminopeptidase activity
GE265_RS14620	COG0477	Major facilitator Superfamily
GE265_RS14685	COG3903	Transcriptional regulator
GE265_RS14685	COG3629	intracellular signal transduction
GE265_RS14715	COG2826	transposase and inactivated derivatives, IS30 family
GE265_RS14755	COG0105	UTP biosynthetic process
GE265_RS14765	COG1051	belongs to the nudix hydrolase family
GE265_RS14770	COG0017	Asparaginyl-tRNA synthetase
GE265_RS14795	COG0151	Belongs to the GarS family
GE265_RS14810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GE265_RS14820	COG2197	response regulator
GE265_RS14855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GE265_RS14860	COG0047	phosphoribosylformylglycinamidine synthase activity
GE265_RS14865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GE265_RS14895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GE265_RS14930	COG1643	Atp-dependent helicase
GE265_RS14940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GE265_RS14940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GE265_RS14945	COG0785	Cytochrome C biogenesis protein
GE265_RS14980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GE265_RS14985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GE265_RS14995	COG0513	Belongs to the DEAD box helicase family
GE265_RS15005	COG0179	Fumarylacetoacetate (FAA) hydrolase
GE265_RS15060	COG0739	heme binding
GE265_RS15060	COG0741	lytic transglycosylase activity
GE265_RS15060	COG1196	nuclear chromosome segregation
GE265_RS15070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GE265_RS15075	COG0579	oxidoreductase
GE265_RS15170	COG0741	lytic transglycosylase activity
GE265_RS15170	COG1196	nuclear chromosome segregation
GE265_RS15170	COG0739	heme binding
GE265_RS15175	COG0671	phosphoesterase, PA-phosphatase related
GE265_RS15195	COG1937	Protein conserved in bacteria
GE265_RS15205	COG0306	phosphate transporter
GE265_RS15230	COG0494	nUDIX hydrolase
GE265_RS15230	COG0406	alpha-ribazole phosphatase activity
GE265_RS15240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GE265_RS15245	COG0456	acetyltransferase
GE265_RS15265	COG0737	Belongs to the 5'-nucleotidase family
GE265_RS15265	COG1525	nuclease
GE265_RS15265	COG4085	toxin activity
GE265_RS15275	COG2188	Transcriptional regulator
GE265_RS15290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GE265_RS15305	COG1609	Transcriptional regulator
GE265_RS15310	COG0745	RESPONSE REGULATOR receiver
GE265_RS15330	COG1309	transcriptional regulator
GE265_RS15355	COG3485	protocatechuate 3,4-dioxygenase
GE265_RS15370	COG1490	D-aminoacyl-tRNA deacylase activity
GE265_RS15430	COG0438	transferase activity, transferring glycosyl groups
GE265_RS15455	COG2211	Major facilitator Superfamily
GE265_RS15460	COG0588	phosphoglycerate mutase activity
GE265_RS15475	COG5002	protein histidine kinase activity
GE265_RS15490	COG1329	Transcriptional regulator
GE265_RS15495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GE265_RS15500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GE265_RS15510	COG0215	cysteine-tRNA ligase activity
GE265_RS15515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE265_RS15525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GE265_RS15535	COG3842	ATPase activity
GE265_RS15550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE265_RS15615	COG0463	Glycosyl transferase, family 2
GE265_RS15640	COG2182	Extracellular solute-binding protein
GE265_RS15645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GE265_RS15660	COG1105	Belongs to the carbohydrate kinase PfkB family
GE265_RS15665	COG0191	fructose-bisphosphate aldolase activity
GE265_RS15690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GE265_RS15710	COG2197	response regulator
GE265_RS15730	COG1605	Chorismate mutase
GE265_RS15735	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS15745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GE265_RS15750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GE265_RS15825	COG1595	DNA-templated transcription, initiation
GE265_RS15840	COG3973	AAA domain
GE265_RS15850	COG1061	Type III restriction enzyme res subunit
GE265_RS15885	COG1278	Cold shock
GE265_RS15890	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GE265_RS15895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GE265_RS15905	COG2814	Major facilitator Superfamily
GE265_RS15925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GE265_RS15935	COG2252	PERMEase
GE265_RS15970	COG0667	Aldo Keto reductase
GE265_RS15990	COG1122	ATPase activity
GE265_RS16030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GE265_RS16045	COG3629	intracellular signal transduction
GE265_RS16045	COG3903	Transcriptional regulator
GE265_RS16055	COG0463	Glycosyl transferase, family 2
GE265_RS16095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GE265_RS16105	COG0247	lactate metabolic process
GE265_RS16105	COG0277	FAD linked oxidase domain protein
GE265_RS16120	COG0745	RESPONSE REGULATOR receiver
GE265_RS16125	COG2205	protein histidine kinase activity
GE265_RS16140	COG0583	DNA-binding transcription factor activity
GE265_RS16175	COG0577	efflux transmembrane transporter activity
GE265_RS16175	COG1136	(ABC) transporter
GE265_RS16180	COG0577	efflux transmembrane transporter activity
GE265_RS16210	COG0726	polysaccharide deacetylase
GE265_RS16255	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS16325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GE265_RS16340	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS16360	COG0259	pyridoxamine-phosphate oxidase activity
GE265_RS16370	COG4821	SIS domain
GE265_RS16380	COG2945	thiolester hydrolase activity
GE265_RS16380	COG0596	Alpha beta hydrolase
GE265_RS16450	COG3397	chitin binding
GE265_RS16455	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS16465	COG1960	acyl-CoA dehydrogenase activity
GE265_RS16470	COG1960	acyl-CoA dehydrogenase activity
GE265_RS16485	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS16490	COG1960	acyl-CoA dehydrogenase activity
GE265_RS16500	COG1917	Cupin 2, conserved barrel domain protein
GE265_RS16500	COG4977	sequence-specific DNA binding
GE265_RS16505	COG2271	Major facilitator Superfamily
GE265_RS16510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GE265_RS16525	COG1181	Belongs to the D-alanine--D-alanine ligase family
GE265_RS16530	COG2814	Major facilitator Superfamily
GE265_RS16530	COG0477	Major facilitator Superfamily
GE265_RS16535	COG0456	acetyltransferase
GE265_RS16545	COG1024	Enoyl-CoA hydratase
GE265_RS16555	COG2072	flavoprotein involved in K transport
GE265_RS16570	COG0259	pyridoxamine-phosphate oxidase activity
GE265_RS16595	COG1960	acyl-CoA dehydrogenase activity
GE265_RS16605	COG0702	epimerase
GE265_RS16625	COG1309	transcriptional regulator
GE265_RS16645	COG1725	Transcriptional regulator
GE265_RS16720	COG1136	(ABC) transporter
GE265_RS16745	COG0596	Alpha beta hydrolase
GE265_RS16750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GE265_RS16855	COG0113	porphobilinogen synthase activity
GE265_RS16875	COG0018	arginyl-trna synthetase
GE265_RS16880	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GE265_RS16895	COG0626	cystathionine gamma-synthase activity
GE265_RS16900	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GE265_RS16940	COG1690	Belongs to the RtcB family
GE265_RS16945	COG0402	S-adenosylhomocysteine deaminase activity
GE265_RS16960	COG1742	UPF0060 membrane protein
GE265_RS16970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GE265_RS16985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GE265_RS16990	COG0406	alpha-ribazole phosphatase activity
GE265_RS16995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GE265_RS17000	COG0785	Cytochrome C biogenesis protein
GE265_RS17005	COG1333	cytochrome c biogenesis protein
GE265_RS17010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GE265_RS17020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GE265_RS17025	COG0109	protoheme IX farnesyltransferase activity
GE265_RS17030	COG0163	prenyltransferase activity
GE265_RS17040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GE265_RS17055	COG1823	symporter activity
GE265_RS17060	COG1278	Cold shock
GE265_RS17065	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GE265_RS17070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GE265_RS17080	COG2226	methyltransferase
GE265_RS17110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17120	COG0649	NAD binding
GE265_RS17130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GE265_RS17135	COG1034	ATP synthesis coupled electron transport
GE265_RS17140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GE265_RS17145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17150	COG0839	Belongs to the complex I subunit 6 family
GE265_RS17155	COG0713	ATP synthesis coupled electron transport
GE265_RS17160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GE265_RS17170	COG1007	ATP synthesis coupled electron transport
GE265_RS17175	COG0179	Fumarylacetoacetate (FAA) hydrolase
GE265_RS17180	COG2936	dipeptidyl-peptidase activity
GE265_RS17185	COG0142	geranyltranstransferase activity
GE265_RS17210	COG2234	aminopeptidase activity
GE265_RS17210	COG4935	Belongs to the peptidase S8 family
GE265_RS17225	COG1733	regulation of RNA biosynthetic process
GE265_RS17250	COG1013	pyruvate-flavodoxin oxidoreductase activity
GE265_RS17255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GE265_RS17255	COG0674	pyruvate-flavodoxin oxidoreductase activity
GE265_RS17270	COG4585	Histidine kinase
GE265_RS17275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GE265_RS17295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GE265_RS17300	COG0839	Belongs to the complex I subunit 6 family
GE265_RS17305	COG0713	ATP synthesis coupled electron transport
GE265_RS17320	COG1007	ATP synthesis coupled electron transport
GE265_RS17325	COG0501	Belongs to the peptidase M48B family
GE265_RS17330	COG3304	Inner membrane component domain
GE265_RS17340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GE265_RS17345	COG1666	GTP binding
GE265_RS17365	COG0702	epimerase
GE265_RS17385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GE265_RS17390	COG2030	dehydratase
GE265_RS17400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GE265_RS17405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GE265_RS17410	COG0436	Aminotransferase
GE265_RS17420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GE265_RS17430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GE265_RS17435	COG0081	regulation of translation
GE265_RS17440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GE265_RS17445	COG0222	ribosome binding
GE265_RS17450	COG0085	RNA polymerase activity
GE265_RS17455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GE265_RS17460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GE265_RS17465	COG0049	tRNA binding
GE265_RS17470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GE265_RS17475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GE265_RS17485	COG0051	transcription antitermination factor activity, RNA binding
GE265_RS17490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GE265_RS17495	COG0088	Forms part of the polypeptide exit tunnel
GE265_RS17500	COG0089	rRNA binding
GE265_RS17505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GE265_RS17510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GE265_RS17515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GE265_RS17520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GE265_RS17525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GE265_RS17530	COG0255	Belongs to the universal ribosomal protein uL29 family
GE265_RS17535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GE265_RS17540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GE265_RS17545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GE265_RS17550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GE265_RS17555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GE265_RS17560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GE265_RS17565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GE265_RS17570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GE265_RS17575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GE265_RS17580	COG1841	ribosomal large subunit assembly
GE265_RS17585	COG0200	Binds to the 23S rRNA
GE265_RS17595	COG0563	adenylate kinase activity
GE265_RS17605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GE265_RS17610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GE265_RS17615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GE265_RS17620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GE265_RS17625	COG0202	RNA polymerase activity
GE265_RS17630	COG0203	ribosomal protein L17
GE265_RS17635	COG0101	tRNA pseudouridine synthase activity
GE265_RS17645	COG0488	(ABC) transporter
GE265_RS17650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GE265_RS17655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GE265_RS17660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE265_RS17665	COG1072	(Pantothenic acid kinase))
GE265_RS17670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GE265_RS17675	COG0736	holo-[acyl-carrier-protein] synthase activity
GE265_RS17695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GE265_RS17705	COG0802	atpase or kinase
GE265_RS17730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GE265_RS17755	COG4941	Belongs to the sigma-70 factor family
GE265_RS17765	COG0726	polysaccharide deacetylase
GE265_RS17770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GE265_RS17775	COG0459	protein refolding
GE265_RS17780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GE265_RS17795	COG0583	DNA-binding transcription factor activity
GE265_RS17805	COG2197	response regulator
GE265_RS17810	COG1595	DNA-templated transcription, initiation
GE265_RS17820	COG0516	GMP reductase activity
GE265_RS17830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GE265_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS17870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GE265_RS17870	COG0519	Catalyzes the synthesis of GMP from XMP
GE265_RS17895	COG2197	response regulator
GE265_RS17915	COG0739	heme binding
GE265_RS17925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS17925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS17940	COG0714	Associated with various cellular activities
GE265_RS17950	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GE265_RS17955	COG0045	succinate-CoA ligase (ADP-forming) activity
GE265_RS17985	COG0138	bifunctional purine biosynthesis protein purh
GE265_RS18000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GE265_RS18015	COG0039	L-malate dehydrogenase activity
GE265_RS18025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GE265_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE265_RS18075	COG0754	glutathionylspermidine amidase activity
GE265_RS18080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GE265_RS18085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GE265_RS18090	COG0180	Tryptophanyl-tRNA synthetase
GE265_RS18115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GE265_RS18120	COG1295	ribonuclease BN
GE265_RS18125	COG1686	Belongs to the peptidase S11 family
GE265_RS18135	COG1408	metallophosphoesterase
GE265_RS18145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GE265_RS18150	COG1053	succinate dehydrogenase
GE265_RS18160	COG2009	succinate dehydrogenase
GE265_RS18165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GE265_RS18175	COG1595	DNA-templated transcription, initiation
GE265_RS18190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS18190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS18205	COG0516	GMP reductase activity
GE265_RS18205	COG0517	IMP dehydrogenase activity
GE265_RS18220	COG1216	Glycosyl transferase, family 2
GE265_RS18230	COG1083	cytidylyl-transferase
GE265_RS18235	COG2089	acid synthase
GE265_RS18245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GE265_RS18245	COG1473	amidohydrolase
GE265_RS18250	COG1744	ABC transporter substrate-binding protein PnrA-like
GE265_RS18255	COG3845	ABC transporter
GE265_RS18260	COG4603	Belongs to the binding-protein-dependent transport system permease family
GE265_RS18265	COG1079	Belongs to the binding-protein-dependent transport system permease family
GE265_RS18300	COG2814	Major facilitator Superfamily
GE265_RS18305	COG0583	DNA-binding transcription factor activity
GE265_RS18320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GE265_RS18345	COG2205	protein histidine kinase activity
GE265_RS18350	COG0745	RESPONSE REGULATOR receiver
GE265_RS18355	COG1595	DNA-templated transcription, initiation
GE265_RS18370	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS18375	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS18405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE265_RS18435	COG4770	biotin carboxylase activity
GE265_RS18440	COG0424	maF-like protein
GE265_RS18450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GE265_RS18465	COG1024	Enoyl-CoA hydratase
GE265_RS18475	COG2986	histidine ammonia-lyase
GE265_RS18490	COG1064	alcohol dehydrogenase
GE265_RS18510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GE265_RS18550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GE265_RS18570	COG2188	Transcriptional regulator
GE265_RS18580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GE265_RS18590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GE265_RS18620	COG1331	Highly conserved protein containing a thioredoxin domain
GE265_RS18625	COG1309	transcriptional regulator
GE265_RS18635	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GE265_RS18675	COG0438	transferase activity, transferring glycosyl groups
GE265_RS18680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GE265_RS18690	COG0728	peptidoglycan biosynthetic process
GE265_RS18725	COG0492	ferredoxin-NADP+ reductase activity
GE265_RS18785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GE265_RS18800	COG1414	Transcriptional regulator
GE265_RS18805	COG0251	oxidation-reduction process
GE265_RS18810	COG2610	gluconate transmembrane transporter activity
GE265_RS18835	COG2894	cell division
GE265_RS18865	COG4585	Histidine kinase
GE265_RS18870	COG2197	response regulator
GE265_RS18890	COG2885	chlorophyll binding
GE265_RS18915	COG0667	Aldo Keto reductase
GE265_RS18920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GE265_RS18925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GE265_RS18940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GE265_RS18945	COG0450	alkyl hydroperoxide reductase
GE265_RS18960	COG1136	(ABC) transporter
GE265_RS18980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE265_RS19000	COG0114	fumarate hydratase activity
GE265_RS19010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GE265_RS19010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GE265_RS19035	COG0778	Nitroreductase
GE265_RS19040	COG1722	exodeoxyribonuclease VII activity
GE265_RS19045	COG1570	exodeoxyribonuclease VII activity
GE265_RS19050	COG0531	amino acid
GE265_RS19055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GE265_RS19070	COG0012	GTP binding
GE265_RS19120	COG1053	succinate dehydrogenase
GE265_RS19140	COG1217	gtp-binding protein TYPA
GE265_RS19145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS19150	COG4166	transmembrane transport
GE265_RS19160	COG0444	Belongs to the ABC transporter superfamily
GE265_RS19165	COG4608	Belongs to the ABC transporter superfamily
GE265_RS19180	COG0601	transmembrane transport
GE265_RS19185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS19190	COG0444	Belongs to the ABC transporter superfamily
GE265_RS19195	COG4608	Belongs to the ABC transporter superfamily
GE265_RS19210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GE265_RS19250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE265_RS19255	COG1611	Belongs to the LOG family
GE265_RS19260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GE265_RS19270	COG0519	Catalyzes the synthesis of GMP from XMP
GE265_RS19275	COG1024	Enoyl-CoA hydratase
GE265_RS19290	COG1595	DNA-templated transcription, initiation
GE265_RS19300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GE265_RS19305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GE265_RS19340	COG0598	Magnesium transport protein CorA
GE265_RS19360	COG2095	MarC family integral membrane protein
GE265_RS19370	COG1432	Conserved Protein
GE265_RS19395	COG0513	Belongs to the DEAD box helicase family
GE265_RS19425	COG0596	Alpha beta hydrolase
GE265_RS19425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GE265_RS19435	COG0747	negative chemotaxis
GE265_RS19440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS19445	COG0601	transmembrane transport
GE265_RS19500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE265_RS19540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GE265_RS19580	COG3480	Lon protease (S16) C-terminal proteolytic domain
GE265_RS19590	COG1615	UPF0182 protein
GE265_RS19615	COG0753	catalase activity
GE265_RS19625	COG0483	inositol monophosphate 1-phosphatase activity
GE265_RS19635	COG2076	Multidrug Resistance protein
GE265_RS19645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GE265_RS19655	COG2135	peptidase activity
GE265_RS19665	COG1595	DNA-templated transcription, initiation
GE265_RS19670	COG5662	AntiSigma factor
GE265_RS19690	COG0242	peptide deformylase activity
GE265_RS19715	COG2188	Transcriptional regulator
GE265_RS19720	COG2182	Extracellular solute-binding protein
GE265_RS19725	COG1175	transmembrane transport
GE265_RS19730	COG0395	ABC-type sugar transport system, permease component
GE265_RS19735	COG1472	Belongs to the glycosyl hydrolase 3 family
GE265_RS19740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GE265_RS19755	COG1597	lipid kinase activity
GE265_RS19790	COG0142	geranyltranstransferase activity
GE265_RS19810	COG5640	endopeptidase activity
GE265_RS19820	COG0494	nUDIX hydrolase
GE265_RS19840	COG4106	trans-aconitate 2-methyltransferase activity
GE265_RS19845	COG1126	abc transporter atp-binding protein
GE265_RS19865	COG0604	alcohol dehydrogenase
GE265_RS19900	COG2255	four-way junction helicase activity
GE265_RS19910	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE265_RS19910	COG0567	Dehydrogenase, E1 component
GE265_RS19915	COG2205	protein histidine kinase activity
GE265_RS19920	COG0745	RESPONSE REGULATOR receiver
GE265_RS19930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GE265_RS19935	COG1357	PFAM Pentapeptide repeats (8 copies)
GE265_RS19955	COG2205	protein histidine kinase activity
GE265_RS19990	COG2318	DinB family
GE265_RS20020	COG0768	penicillin binding
GE265_RS20075	COG1793	dna ligase
GE265_RS20080	COG3285	dna ligase
GE265_RS20080	COG1793	dna ligase
GE265_RS20085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GE265_RS20090	COG2072	flavoprotein involved in K transport
GE265_RS20110	COG0745	RESPONSE REGULATOR receiver
GE265_RS20115	COG2205	protein histidine kinase activity
GE265_RS20125	COG2124	cytochrome p450
GE265_RS20130	COG0768	penicillin binding
GE265_RS20135	COG0768	penicillin binding
GE265_RS20140	COG1181	Belongs to the D-alanine--D-alanine ligase family
GE265_RS20150	COG0747	negative chemotaxis
GE265_RS20155	COG0456	acetyltransferase
GE265_RS20160	COG0697	spore germination
GE265_RS20200	COG2175	clavaminate synthase activity
GE265_RS20205	COG0010	Belongs to the arginase family
GE265_RS20210	COG0367	asparagine synthase
GE265_RS20220	COG0768	penicillin binding
GE265_RS20225	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
GE265_RS20235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GE265_RS20245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GE265_RS20255	COG2192	nodulation
GE265_RS20275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE265_RS20280	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
GE265_RS20285	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS20295	COG1686	Belongs to the peptidase S11 family
GE265_RS20300	COG2367	Beta-lactamase
GE265_RS20385	COG1674	ftsk spoiiie
GE265_RS20440	COG0018	arginyl-trna synthetase
GE265_RS20445	COG0019	diaminopimelate decarboxylase activity
GE265_RS20450	COG0460	homoserine dehydrogenase
GE265_RS20455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GE265_RS20460	COG0083	homoserine kinase activity
GE265_RS20475	COG1316	TRANSCRIPTIONal
GE265_RS20480	COG0254	rRNA binding
GE265_RS20485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GE265_RS20490	COG2890	protein-(glutamine-N5) methyltransferase activity
GE265_RS20500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GE265_RS20505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GE265_RS20525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GE265_RS20530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GE265_RS20535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GE265_RS20540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GE265_RS20545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GE265_RS20550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GE265_RS20555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GE265_RS20570	COG0494	nUDIX hydrolase
GE265_RS20580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS20610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GE265_RS20630	COG1088	dTDP-glucose 4,6-dehydratase activity
GE265_RS20640	COG2197	response regulator
GE265_RS20645	COG4585	Histidine kinase
GE265_RS20660	COG1250	3-hydroxyacyl-CoA dehydrogenase
GE265_RS20675	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GE265_RS20710	COG1131	(ABC) transporter
GE265_RS20730	COG0183	Belongs to the thiolase family
GE265_RS20745	COG0745	RESPONSE REGULATOR receiver
GE265_RS20790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS20790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS20825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GE265_RS20830	COG0280	phosphate acetyltransferase
GE265_RS20830	COG0857	belongs to the CobB CobQ family
GE265_RS20835	COG0205	6-phosphofructokinase activity
GE265_RS20845	COG1175	transmembrane transport
GE265_RS20875	COG0181	hydroxymethylbilane synthase activity
GE265_RS20880	COG4565	transcriptional regulatory protein
GE265_RS20885	COG3290	protein histidine kinase activity
GE265_RS20890	COG1301	dicarboxylic acid transport
GE265_RS20905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GE265_RS20915	COG0366	Alpha amylase catalytic
GE265_RS20920	COG0366	Alpha amylase catalytic
GE265_RS20925	COG0058	SHG alpha-glucan phosphorylase activity
GE265_RS20935	COG4585	Histidine kinase
GE265_RS20940	COG2197	response regulator
GE265_RS20975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GE265_RS20985	COG1132	(ABC) transporter
GE265_RS20990	COG1132	(ABC) transporter
GE265_RS21005	COG1024	Enoyl-CoA hydratase
GE265_RS21145	COG2856	Zn peptidase
GE265_RS21155	COG1760	l-serine dehydratase
GE265_RS21160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GE265_RS21165	COG0509	glycine decarboxylation via glycine cleavage system
GE265_RS21170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GE265_RS21190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS21195	COG0747	negative chemotaxis
GE265_RS21200	COG0601	transmembrane transport
GE265_RS21205	COG0444	Belongs to the ABC transporter superfamily
GE265_RS21210	COG4608	Belongs to the ABC transporter superfamily
GE265_RS21215	COG2860	membrane
GE265_RS21240	COG0482	sulfurtransferase activity
GE265_RS21250	COG1611	Belongs to the LOG family
GE265_RS21255	COG4221	oxidoreductase activity
GE265_RS21265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GE265_RS21275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GE265_RS21280	COG0154	amidase activity
GE265_RS21290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GE265_RS21300	COG2409	Drug exporters of the RND superfamily
GE265_RS21305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE265_RS21320	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GE265_RS21320	COG1672	PFAM Archaeal ATPase
GE265_RS21330	COG2133	pyrroloquinoline quinone binding
GE265_RS21335	COG0667	Aldo Keto reductase
GE265_RS21355	COG0440	acetolactate synthase activity
GE265_RS21360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GE265_RS21365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GE265_RS21370	COG2508	Transcriptional regulator
GE265_RS21370	COG2508	Transcriptional regulator
GE265_RS21375	COG0506	proline dehydrogenase activity
GE265_RS21380	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS21385	COG0640	Transcriptional regulator
GE265_RS21445	COG1082	Xylose isomerase domain protein TIM barrel
GE265_RS21460	COG0473	3-isopropylmalate dehydrogenase activity
GE265_RS21465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GE265_RS21490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS21500	COG0300	oxidoreductase activity
GE265_RS21525	COG0831	urea catabolic process
GE265_RS21525	COG0832	Belongs to the urease beta subunit family
GE265_RS21535	COG0804	urea catabolic process
GE265_RS21540	COG2957	Belongs to the agmatine deiminase family
GE265_RS21550	COG0477	Major facilitator Superfamily
GE265_RS21555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GE265_RS21565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GE265_RS21585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GE265_RS21605	COG2018	Roadblock/LC7 domain
GE265_RS21625	COG2018	Roadblock/LC7 domain
GE265_RS21630	COG5002	protein histidine kinase activity
GE265_RS21640	COG0179	Fumarylacetoacetate (FAA) hydrolase
GE265_RS21645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GE265_RS21650	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GE265_RS21680	COG1414	Transcriptional regulator
GE265_RS21685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GE265_RS21690	COG0066	3-isopropylmalate dehydratase activity
GE265_RS21700	COG0776	regulation of translation
GE265_RS21710	COG1920	GTP binding
GE265_RS21720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GE265_RS21725	COG1181	Belongs to the D-alanine--D-alanine ligase family
GE265_RS21740	COG0351	phosphomethylpyrimidine kinase
GE265_RS21745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GE265_RS21750	COG1461	Dihydroxyacetone kinase
GE265_RS21760	COG0742	ribosomal rna small subunit methyltransferase
GE265_RS21765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GE265_RS21780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GE265_RS21785	COG0571	ribonuclease III activity
GE265_RS21790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GE265_RS21795	COG2340	Cysteine-rich secretory protein family
GE265_RS21800	COG1254	Belongs to the acylphosphatase family
GE265_RS21815	COG1196	nuclear chromosome segregation
GE265_RS21820	COG0477	Major facilitator Superfamily
GE265_RS21825	COG4552	Acetyltransferase involved in intracellular survival and related
GE265_RS21855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GE265_RS21865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GE265_RS21875	COG0228	four-way junction DNA binding
GE265_RS21880	COG1837	Belongs to the UPF0109 family
GE265_RS21885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GE265_RS21890	COG0336	Belongs to the RNA methyltransferase TrmD family
GE265_RS21895	COG0335	large ribosomal subunit rRNA binding
GE265_RS21900	COG0681	Belongs to the peptidase S26 family
GE265_RS21915	COG0681	Belongs to the peptidase S26 family
GE265_RS21925	COG0792	nuclease activity
GE265_RS21940	COG1191	sigma factor activity
GE265_RS21955	COG0052	Belongs to the universal ribosomal protein uS2 family
GE265_RS21960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GE265_RS21965	COG0528	UMP kinase activity
GE265_RS21970	COG0233	cytoplasmic translational termination
GE265_RS21975	COG0575	Belongs to the CDS family
GE265_RS21980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GE265_RS21995	COG3842	ATPase activity
GE265_RS22010	COG1136	(ABC) transporter
GE265_RS22015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS22025	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS22040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GE265_RS22065	COG3842	ATPase activity
GE265_RS22070	COG1176	ABC-type spermidine putrescine transport system, permease component I
GE265_RS22075	COG1177	transmembrane transport
GE265_RS22080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE265_RS22110	COG2508	Transcriptional regulator
GE265_RS22125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GE265_RS22130	COG0750	zinc metalloprotease
GE265_RS22135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GE265_RS22150	COG0442	prolyl-tRNA aminoacylation
GE265_RS22170	COG0779	Required for maturation of 30S ribosomal subunits
GE265_RS22185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GE265_RS22195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GE265_RS22200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GE265_RS22220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS22225	COG0601	transmembrane transport
GE265_RS22230	COG0747	negative chemotaxis
GE265_RS22235	COG0455	bacterial-type flagellum organization
GE265_RS22255	COG3266	domain, Protein
GE265_RS22260	COG1404	Belongs to the peptidase S8 family
GE265_RS22275	COG1404	Belongs to the peptidase S8 family
GE265_RS22290	COG1674	ftsk spoiiie
GE265_RS22300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GE265_RS22305	COG1185	polyribonucleotide nucleotidyltransferase activity
GE265_RS22310	COG0612	Peptidase, M16
GE265_RS22315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GE265_RS22335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GE265_RS22340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE265_RS22345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GE265_RS22370	COG2208	phosphoserine phosphatase activity
GE265_RS22370	COG2770	Histidine kinase
GE265_RS22375	COG5002	protein histidine kinase activity
GE265_RS22375	COG0784	Response regulator, receiver
GE265_RS22385	COG1674	ftsk spoiiie
GE265_RS22395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GE265_RS22405	COG1058	Belongs to the CinA family
GE265_RS22405	COG1546	Belongs to the CinA family
GE265_RS22410	COG1396	sequence-specific DNA binding
GE265_RS22415	COG0783	Belongs to the Dps family
GE265_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS22425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GE265_RS22430	COG1201	RNA secondary structure unwinding
GE265_RS22470	COG2137	regulation of response to DNA damage stimulus
GE265_RS22485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GE265_RS22490	COG0765	amino acid transport
GE265_RS22495	COG0765	amino acid transport
GE265_RS22500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE265_RS22505	COG1126	abc transporter atp-binding protein
GE265_RS22510	COG0745	RESPONSE REGULATOR receiver
GE265_RS22515	COG2205	protein histidine kinase activity
GE265_RS22520	COG2358	TRAP transporter, solute receptor (TAXI family
GE265_RS22525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GE265_RS22545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GE265_RS22555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GE265_RS22560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GE265_RS22570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GE265_RS22600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GE265_RS22605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GE265_RS22610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GE265_RS22635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GE265_RS22665	COG1131	(ABC) transporter
GE265_RS22670	COG2186	Transcriptional regulator
GE265_RS22675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GE265_RS22690	COG0187	DNA topoisomerase II activity
GE265_RS22695	COG4565	transcriptional regulatory protein
GE265_RS22700	COG3290	protein histidine kinase activity
GE265_RS22710	COG0372	Belongs to the citrate synthase family
GE265_RS22720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GE265_RS22725	COG0612	Peptidase, M16
GE265_RS22735	COG0739	heme binding
GE265_RS22735	COG0741	lytic transglycosylase activity
GE265_RS22735	COG1196	nuclear chromosome segregation
GE265_RS22740	COG1802	Transcriptional regulator
GE265_RS22745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE265_RS22750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE265_RS22750	COG1042	CoA-binding domain protein
GE265_RS22750	COG0045	succinate-CoA ligase (ADP-forming) activity
GE265_RS22765	COG1435	thymidine kinase activity
GE265_RS22780	COG0702	epimerase
GE265_RS22790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE265_RS22805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS22810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS22815	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GE265_RS22880	COG2264	protein methyltransferase activity
GE265_RS22890	COG3629	intracellular signal transduction
GE265_RS22890	COG3903	Transcriptional regulator
GE265_RS22910	COG2409	Drug exporters of the RND superfamily
GE265_RS22965	COG0142	geranyltranstransferase activity
GE265_RS22995	COG0494	nUDIX hydrolase
GE265_RS23010	COG2264	protein methyltransferase activity
GE265_RS23015	COG0483	inositol monophosphate 1-phosphatase activity
GE265_RS23025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GE265_RS23030	COG0531	amino acid
GE265_RS23035	COG0569	domain protein
GE265_RS23045	COG1136	(ABC) transporter
GE265_RS23045	COG0577	efflux transmembrane transporter activity
GE265_RS23080	COG1136	(ABC) transporter
GE265_RS23080	COG4591	ABC-type transport system involved in lipoprotein release permease component
GE265_RS23090	COG0756	dUTP diphosphatase activity
GE265_RS23115	COG2205	protein histidine kinase activity
GE265_RS23120	COG0745	RESPONSE REGULATOR receiver
GE265_RS23135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GE265_RS23165	COG4689	acetoacetate decarboxylase
GE265_RS23185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GE265_RS23200	COG3629	intracellular signal transduction
GE265_RS23200	COG3903	Transcriptional regulator
GE265_RS23205	COG1799	cell septum assembly
GE265_RS23225	COG2040	homocysteine
GE265_RS23245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GE265_RS23255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GE265_RS23260	COG1024	Enoyl-CoA hydratase
GE265_RS23305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GE265_RS23325	COG1522	sequence-specific DNA binding
GE265_RS23330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GE265_RS23340	COG1653	transport
GE265_RS23345	COG1175	transmembrane transport
GE265_RS23350	COG0395	ABC-type sugar transport system, permease component
GE265_RS23355	COG1940	carbohydrate kinase activity
GE265_RS23360	COG4213	ABC transporter substrate-binding protein
GE265_RS23370	COG4214	carbohydrate transport
GE265_RS23375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GE265_RS23380	COG0531	amino acid
GE265_RS23390	COG1250	3-hydroxyacyl-CoA dehydrogenase
GE265_RS23390	COG1024	Enoyl-CoA hydratase
GE265_RS23395	COG0183	Belongs to the thiolase family
GE265_RS23415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GE265_RS23420	COG0446	pyridine nucleotide-disulphide oxidoreductase
GE265_RS23430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GE265_RS23435	COG3253	May function as heme-dependent peroxidase
GE265_RS23455	COG3220	belongs to the UPF0276 family
GE265_RS23475	COG1846	Transcriptional regulator
GE265_RS23480	COG1764	response to oxidative stress
GE265_RS23505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GE265_RS23510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GE265_RS23585	COG1175	transmembrane transport
GE265_RS23620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GE265_RS23625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GE265_RS23645	COG0529	Catalyzes the synthesis of activated sulfate
GE265_RS23650	COG0175	sulfate reduction
GE265_RS23670	COG3284	Transcriptional regulator
GE265_RS23675	COG1960	acyl-CoA dehydrogenase activity
GE265_RS23715	COG3290	protein histidine kinase activity
GE265_RS23745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS23770	COG1162	GTPase activity
GE265_RS23800	COG0028	Belongs to the TPP enzyme family
GE265_RS23820	COG1802	Transcriptional regulator
GE265_RS23835	COG3842	ATPase activity
GE265_RS23845	COG1840	ABC-type Fe3 transport system, periplasmic component
GE265_RS23850	COG3835	regulator
GE265_RS23865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GE265_RS23910	COG1609	Transcriptional regulator
GE265_RS23920	COG0515	serine threonine protein kinase
GE265_RS23930	COG1132	(ABC) transporter
GE265_RS23935	COG1132	(ABC) transporter
GE265_RS23940	COG2197	response regulator
GE265_RS23955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS23970	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS23975	COG2345	Transcriptional regulator
GE265_RS23990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GE265_RS24025	COG0243	molybdopterin cofactor binding
GE265_RS24040	COG1404	Belongs to the peptidase S8 family
GE265_RS24060	COG3409	Peptidoglycan-binding domain 1 protein
GE265_RS24075	COG2197	response regulator
GE265_RS24080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GE265_RS24085	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS24110	COG2351	hydroxyisourate hydrolase activity
GE265_RS24140	COG1288	antiporter activity
GE265_RS24155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GE265_RS24165	COG0746	molybdenum cofactor guanylyltransferase activity
GE265_RS24180	COG1414	Transcriptional regulator
GE265_RS24185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GE265_RS24190	COG4266	Belongs to the allantoicase family
GE265_RS24205	COG4585	Histidine kinase
GE265_RS24210	COG2197	response regulator
GE265_RS24220	COG0673	inositol 2-dehydrogenase activity
GE265_RS24225	COG2188	Transcriptional regulator
GE265_RS24245	COG1940	carbohydrate kinase activity
GE265_RS24255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GE265_RS24275	COG1126	abc transporter atp-binding protein
GE265_RS24280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE265_RS24285	COG0765	amino acid transport
GE265_RS24290	COG0765	amino acid transport
GE265_RS24300	COG0405	Gamma-glutamyltransferase
GE265_RS24330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GE265_RS24335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GE265_RS24345	COG0095	Lipoate-protein ligase
GE265_RS24350	COG0483	inositol monophosphate 1-phosphatase activity
GE265_RS24365	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GE265_RS24375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GE265_RS24380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GE265_RS24395	COG1929	Belongs to the glycerate kinase type-1 family
GE265_RS24405	COG0688	phosphatidylethanolamine metabolic process
GE265_RS24410	COG1960	acyl-CoA dehydrogenase activity
GE265_RS24425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS24425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GE265_RS24430	COG0604	alcohol dehydrogenase
GE265_RS24485	COG2362	D-Aminopeptidase
GE265_RS24490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE265_RS24500	COG1619	proteins homologs of microcin C7 resistance protein MccF
GE265_RS24505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GE265_RS24575	COG1063	alcohol dehydrogenase
GE265_RS24625	COG1793	dna ligase
GE265_RS24635	COG0656	L-ascorbic acid biosynthetic process
GE265_RS24645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GE265_RS24650	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GE265_RS24665	COG3250	beta-galactosidase activity
GE265_RS24675	COG3250	beta-galactosidase activity
GE265_RS24685	COG1595	DNA-templated transcription, initiation
GE265_RS24705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GE265_RS24710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GE265_RS24720	COG1940	carbohydrate kinase activity
GE265_RS24725	COG1129	ABC transporter
GE265_RS24730	COG1172	Belongs to the binding-protein-dependent transport system permease family
GE265_RS24735	COG4213	ABC transporter substrate-binding protein
GE265_RS24740	COG0673	inositol 2-dehydrogenase activity
GE265_RS24765	COG1082	Xylose isomerase domain protein TIM barrel
GE265_RS24855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GE265_RS24860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GE265_RS24865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GE265_RS24880	COG0475	glutathione-regulated potassium exporter activity
GE265_RS24970	COG3345	alpha-galactosidase
GE265_RS24975	COG1609	Transcriptional regulator
GE265_RS25005	COG3012	SEC-C Motif Domain Protein
GE265_RS25045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GE265_RS25100	COG1793	dna ligase
GE265_RS25140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GE265_RS25145	COG0488	(ABC) transporter
GE265_RS25160	COG1515	deoxyribonuclease V activity
GE265_RS25165	COG3268	Saccharopine dehydrogenase
GE265_RS25170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GE265_RS25175	COG0183	Belongs to the thiolase family
GE265_RS25180	COG1024	Enoyl-CoA hydratase
GE265_RS25180	COG1250	3-hydroxyacyl-CoA dehydrogenase
GE265_RS25200	COG2936	dipeptidyl-peptidase activity
GE265_RS25210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GE265_RS25225	COG2183	response to ionizing radiation
GE265_RS25255	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GE265_RS25280	COG0371	Dehydrogenase
GE265_RS25295	COG1134	teichoic acid transport
GE265_RS25300	COG1562	ergosterol biosynthetic process
GE265_RS25310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GE265_RS25320	COG1657	PFAM Prenyltransferase squalene oxidase
GE265_RS25350	COG2365	Tyrosine phosphatase family
GE265_RS25360	COG1196	nuclear chromosome segregation
GE265_RS25360	COG0739	heme binding
GE265_RS25360	COG0741	lytic transglycosylase activity
GE265_RS25370	COG1309	transcriptional regulator
GE265_RS25375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GE265_RS25410	COG1960	acyl-CoA dehydrogenase activity
GE265_RS25415	COG4948	Mandelate Racemase Muconate Lactonizing
GE265_RS25420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GE265_RS25430	COG1116	anion transmembrane transporter activity
GE265_RS25475	COG1960	acyl-CoA dehydrogenase activity
GE265_RS25565	COG3511	phospholipase C
GE265_RS25625	COG2850	peptidyl-arginine hydroxylation
GE265_RS25630	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS25675	COG0673	inositol 2-dehydrogenase activity
GE265_RS25715	COG0187	DNA topoisomerase II activity
GE265_RS25725	COG2226	methyltransferase
GE265_RS25745	COG0477	Major facilitator Superfamily
GE265_RS25795	COG4981	capsule polysaccharide biosynthetic process
GE265_RS25800	COG0500	methyltransferase
GE265_RS25835	COG0438	transferase activity, transferring glycosyl groups
GE265_RS25880	COG0247	lactate metabolic process
GE265_RS25885	COG1139	Iron-sulfur cluster binding protein
GE265_RS25890	COG1556	Lactate utilization protein
GE265_RS25915	COG2072	flavoprotein involved in K transport
GE265_RS25945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GE265_RS25960	COG2205	protein histidine kinase activity
GE265_RS25965	COG0745	RESPONSE REGULATOR receiver
GE265_RS25980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GE265_RS25980	COG2755	lipolytic protein G-D-S-L family
GE265_RS26000	COG0579	oxidoreductase
GE265_RS26005	COG0477	Major facilitator Superfamily
GE265_RS26010	COG0154	amidase activity
GE265_RS26015	COG2197	response regulator
GE265_RS26035	COG4552	Acetyltransferase involved in intracellular survival and related
GE265_RS26050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GE265_RS26055	COG1120	ATPase activity
GE265_RS26060	COG2207	Transcriptional regulator
GE265_RS26075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS26085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GE265_RS26095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GE265_RS26135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GE265_RS26155	COG2957	Belongs to the agmatine deiminase family
GE265_RS26190	COG1174	glycine betaine transport
GE265_RS26195	COG1174	glycine betaine transport
GE265_RS26215	COG0477	Major facilitator Superfamily
GE265_RS26220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GE265_RS26260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GE265_RS26260	COG0574	Belongs to the PEP-utilizing enzyme family
GE265_RS26280	COG1597	lipid kinase activity
GE265_RS26285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GE265_RS26290	COG3629	intracellular signal transduction
GE265_RS26290	COG3903	Transcriptional regulator
GE265_RS26325	COG1309	transcriptional regulator
GE265_RS26345	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS26375	COG1131	(ABC) transporter
GE265_RS26460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GE265_RS26465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GE265_RS26500	COG3959	Transketolase, thiamine diphosphate binding domain
GE265_RS26510	COG3424	synthase
GE265_RS26520	COG0535	radical SAM domain protein
GE265_RS26540	COG1376	ErfK ybiS ycfS ynhG family protein
GE265_RS26545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE265_RS26565	COG0183	Belongs to the thiolase family
GE265_RS26615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GE265_RS26620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GE265_RS26625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GE265_RS26675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GE265_RS26680	COG2326	polyphosphate kinase activity
GE265_RS26710	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS26730	COG1413	lyase activity
GE265_RS26750	COG0402	S-adenosylhomocysteine deaminase activity
GE265_RS26765	COG0463	Glycosyl transferase, family 2
GE265_RS26800	COG2124	cytochrome p450
GE265_RS26825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GE265_RS26825	COG1024	Enoyl-CoA hydratase
GE265_RS26845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GE265_RS26870	COG2124	cytochrome p450
GE265_RS26885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GE265_RS26905	COG1309	transcriptional regulator
GE265_RS26915	COG1174	glycine betaine transport
GE265_RS26920	COG1174	glycine betaine transport
GE265_RS26935	COG3458	cephalosporin-C deacetylase activity
GE265_RS26940	COG0517	IMP dehydrogenase activity
GE265_RS26940	COG1125	glycine betaine transport
GE265_RS26970	COG1960	acyl-CoA dehydrogenase activity
GE265_RS26975	COG1960	acyl-CoA dehydrogenase activity
GE265_RS26985	COG0601	transmembrane transport
GE265_RS26990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE265_RS26995	COG0444	Belongs to the ABC transporter superfamily
GE265_RS27000	COG1124	(ABC) transporter
GE265_RS27040	COG2124	cytochrome p450
GE265_RS27045	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS27095	COG2376	Dihydroxyacetone kinase
GE265_RS27100	COG2376	Dihydroxyacetone kinase
GE265_RS27105	COG2130	NADP-dependent
GE265_RS27110	COG1233	COG1233 Phytoene dehydrogenase and related
GE265_RS27135	COG1233	COG1233 Phytoene dehydrogenase and related
GE265_RS27140	COG1653	transport
GE265_RS27155	COG2208	phosphoserine phosphatase activity
GE265_RS27155	COG1366	Belongs to the anti-sigma-factor antagonist family
GE265_RS27155	COG2172	sigma factor antagonist activity
GE265_RS27160	COG0542	response to heat
GE265_RS27175	COG1846	Transcriptional regulator
GE265_RS27220	COG0473	3-isopropylmalate dehydrogenase activity
GE265_RS27255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GE265_RS27260	COG0438	transferase activity, transferring glycosyl groups
GE265_RS27295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GE265_RS27295	COG0438	transferase activity, transferring glycosyl groups
GE265_RS27305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GE265_RS27320	COG4310	Domain of unknown function (DUF2172)
GE265_RS27330	COG1215	transferase activity, transferring glycosyl groups
GE265_RS27345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GE265_RS27375	COG2124	cytochrome p450
GE265_RS27390	COG0142	geranyltranstransferase activity
GE265_RS27395	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS27405	COG0531	amino acid
GE265_RS27410	COG1012	belongs to the aldehyde dehydrogenase family
GE265_RS27430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GE265_RS27445	COG2018	Roadblock/LC7 domain
GE265_RS27455	COG0156	8-amino-7-oxononanoate synthase activity
GE265_RS27460	COG1063	alcohol dehydrogenase
GE265_RS27485	COG2814	Major facilitator Superfamily
GE265_RS27510	COG0569	domain protein
GE265_RS27510	COG0475	glutathione-regulated potassium exporter activity
GE265_RS27535	COG0019	diaminopimelate decarboxylase activity
GE265_RS27560	COG1966	Carbon starvation protein
GE265_RS27590	COG1280	lysine exporter protein (LysE YggA)
GE265_RS27595	COG0454	-acetyltransferase
GE265_RS27610	COG1192	Involved in chromosome partitioning
GE265_RS27770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GE265_RS27815	COG2161	toxin-antitoxin pair type II binding
GE265_RS27860	COG3547	Transposase (IS116 IS110 IS902 family)
GE265_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS27870	COG0583	DNA-binding transcription factor activity
GE265_RS27910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GE265_RS28130	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GE265_RS28155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GE265_RS28155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GE265_RS28240	COG1674	ftsk spoiiie
GE265_RS28285	COG1475	DNA binding
GE265_RS28410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS28415	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS28420	COG1120	ATPase activity
GE265_RS28430	COG1132	(ABC) transporter
GE265_RS28435	COG1132	(ABC) transporter
GE265_RS28450	COG0583	DNA-binding transcription factor activity
GE265_RS28455	COG1960	acyl-CoA dehydrogenase activity
GE265_RS28470	COG4221	oxidoreductase activity
GE265_RS28480	COG1959	2 iron, 2 sulfur cluster binding
GE265_RS28485	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS28490	COG0640	Transcriptional regulator
GE265_RS28495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GE265_RS28525	COG0739	heme binding
GE265_RS28530	COG1652	LysM domain
GE265_RS28555	COG3479	Phenolic acid decarboxylase
GE265_RS28595	COG0535	radical SAM domain protein
GE265_RS28625	COG1595	DNA-templated transcription, initiation
GE265_RS28765	COG0297	glycogen (starch) synthase activity
GE265_RS28770	COG2175	clavaminate synthase activity
GE265_RS28775	COG2192	nodulation
GE265_RS28800	COG1846	Transcriptional regulator
GE265_RS28870	COG0513	Belongs to the DEAD box helicase family
GE265_RS28875	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS28910	COG1045	serine acetyltransferase
GE265_RS28915	COG0697	spore germination
GE265_RS28930	COG2843	Capsule synthesis protein
GE265_RS28960	COG5434	Belongs to the glycosyl hydrolase 28 family
GE265_RS28965	COG0642	Histidine kinase
GE265_RS28970	COG0745	RESPONSE REGULATOR receiver
GE265_RS28975	COG0531	amino acid
GE265_RS28980	COG1285	pathogenesis
GE265_RS28985	COG2239	Acts as a magnesium transporter
GE265_RS29005	COG0174	glutamine synthetase
GE265_RS29020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GE265_RS29050	COG1136	(ABC) transporter
GE265_RS29055	COG0577	efflux transmembrane transporter activity
GE265_RS29060	COG0745	RESPONSE REGULATOR receiver
GE265_RS29065	COG2205	protein histidine kinase activity
GE265_RS29110	COG3433	isochorismatase activity
GE265_RS29110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS29110	COG2226	methyltransferase
GE265_RS29130	COG3119	arylsulfatase activity
GE265_RS29145	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS29210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS29225	COG2132	Multicopper oxidase
GE265_RS29255	COG3119	arylsulfatase activity
GE265_RS29275	COG1940	carbohydrate kinase activity
GE265_RS29325	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GE265_RS29325	COG3266	domain, Protein
GE265_RS29325	COG4932	domain protein
GE265_RS29340	COG2837	iron assimilation
GE265_RS29350	COG1404	Belongs to the peptidase S8 family
GE265_RS29370	COG1088	dTDP-glucose 4,6-dehydratase activity
GE265_RS29375	COG1960	acyl-CoA dehydrogenase activity
GE265_RS29380	COG0477	Major facilitator Superfamily
GE265_RS29405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GE265_RS29410	COG2226	methyltransferase
GE265_RS29415	COG0596	Alpha beta hydrolase
GE265_RS29440	COG2207	Transcriptional regulator
GE265_RS29445	COG2124	cytochrome p450
GE265_RS29485	COG2271	Major facilitator Superfamily
GE265_RS29515	COG2986	histidine ammonia-lyase
GE265_RS29540	COG0076	glutamate decarboxylase activity
GE265_RS29560	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS29565	COG3320	Male sterility
GE265_RS29565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS29575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS29590	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GE265_RS29640	COG2318	DinB family
GE265_RS29670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS29675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS29685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS29695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GE265_RS29700	COG0159	tryptophan synthase activity
GE265_RS29705	COG0662	Cupin 2, conserved barrel domain protein
GE265_RS29710	COG1960	acyl-CoA dehydrogenase activity
GE265_RS29715	COG0135	phosphoribosylanthranilate isomerase activity
GE265_RS29720	COG0134	indole-3-glycerol-phosphate synthase activity
GE265_RS29730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GE265_RS29740	COG1216	Glycosyl transferase, family 2
GE265_RS29750	COG1131	(ABC) transporter
GE265_RS29770	COG2192	nodulation
GE265_RS29780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GE265_RS29800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GE265_RS29810	COG1132	(ABC) transporter
GE265_RS29815	COG0156	8-amino-7-oxononanoate synthase activity
GE265_RS29820	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS29865	COG3547	Transposase (IS116 IS110 IS902 family)
GE265_RS29875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GE265_RS29880	COG0318	PFAM AMP-dependent synthetase and ligase
GE265_RS29945	COG2197	response regulator
GE265_RS29975	COG2814	Major facilitator Superfamily
GE265_RS29980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GE265_RS29995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GE265_RS30035	COG3321	synthase
GE265_RS30035	COG0604	alcohol dehydrogenase
GE265_RS30055	COG2814	Major facilitator Superfamily
GE265_RS30075	COG0076	glutamate decarboxylase activity
GE265_RS30110	COG0531	amino acid
GE265_RS30120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GE265_RS30135	COG2304	oxidoreductase activity
GE265_RS30175	COG2197	response regulator
GE265_RS30185	COG1222	aaa ATPase
GE265_RS30195	COG3629	intracellular signal transduction
GE265_RS30195	COG3903	Transcriptional regulator
GE265_RS30270	COG2124	cytochrome p450
GE265_RS30300	COG0789	Transcriptional regulator
GE265_RS30305	COG0436	Aminotransferase
GE265_RS30315	COG1695	Transcriptional regulator
GE265_RS30320	COG2124	cytochrome p450
GE265_RS30325	COG2124	cytochrome p450
GE265_RS30330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GE265_RS30335	COG0346	lactoylglutathione lyase activity
GE265_RS30340	COG0640	Transcriptional regulator
GE265_RS30350	COG2226	methyltransferase
GE265_RS30360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GE265_RS30410	COG1136	(ABC) transporter
GE265_RS30410	COG0577	efflux transmembrane transporter activity
GE265_RS30415	COG0577	efflux transmembrane transporter activity
GE265_RS30415	COG1136	(ABC) transporter
GE265_RS30430	COG0745	RESPONSE REGULATOR receiver
GE265_RS30435	COG2205	protein histidine kinase activity
GE265_RS30465	COG4948	Mandelate Racemase Muconate Lactonizing
GE265_RS30500	COG2124	cytochrome p450
GE265_RS30510	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS30620	COG2124	cytochrome p450
GE265_RS30645	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GE265_RS30680	COG2319	Wd-40 repeat
GE265_RS30680	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS30685	COG1335	isochorismatase
GE265_RS30725	COG3409	Peptidoglycan-binding domain 1 protein
GE265_RS30730	COG3973	AAA domain
GE265_RS30760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GE265_RS30765	COG5183	chlorophyll binding
GE265_RS30765	COG2133	pyrroloquinoline quinone binding
GE265_RS30790	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS30800	COG2201	protein-glutamate methylesterase activity
GE265_RS30815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS30820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GE265_RS30825	COG0010	Belongs to the arginase family
GE265_RS30830	COG0367	asparagine synthase
GE265_RS30850	COG0436	Aminotransferase
GE265_RS30855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GE265_RS30865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GE265_RS30880	COG0583	DNA-binding transcription factor activity
GE265_RS30925	COG2111	Na H antiporter
GE265_RS30925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GE265_RS30930	COG1006	Multisubunit Na H antiporter MnhC subunit
GE265_RS30935	COG0651	ATP synthesis coupled electron transport
GE265_RS30950	COG1320	monovalent cation:proton antiporter activity
GE265_RS31095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GE265_RS31140	COG1121	(ABC) transporter
GE265_RS31145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GE265_RS31165	COG0076	glutamate decarboxylase activity
GE265_RS31180	COG1125	glycine betaine transport
GE265_RS31180	COG0517	IMP dehydrogenase activity
GE265_RS31185	COG1174	glycine betaine transport
GE265_RS31190	COG1732	Glycine betaine
GE265_RS31195	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
GE265_RS31250	COG1228	amidohydrolase
GE265_RS31255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS31265	COG2816	NAD+ diphosphatase activity
GE265_RS31275	COG4552	Acetyltransferase involved in intracellular survival and related
GE265_RS31285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GE265_RS31310	COG1940	carbohydrate kinase activity
GE265_RS31315	COG0363	glucosamine-6-phosphate deaminase activity
GE265_RS31330	COG0546	phosphoglycolate phosphatase activity
GE265_RS31370	COG0477	Major facilitator Superfamily
GE265_RS31410	COG0110	maltose O-acetyltransferase activity
GE265_RS31455	COG1024	Enoyl-CoA hydratase
GE265_RS31485	COG0301	tRNA thio-modification
GE265_RS31490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GE265_RS31500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GE265_RS31525	COG0640	Transcriptional regulator
GE265_RS31560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS31565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS31570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE265_RS31580	COG0431	NADPH-dependent FMN reductase
GE265_RS31595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GE265_RS31600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GE265_RS31630	COG2319	Wd-40 repeat
GE265_RS31630	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS31725	COG2318	DinB family
GE265_RS31775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GE265_RS31800	COG1309	transcriptional regulator
GE265_RS31810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GE265_RS31815	COG1725	Transcriptional regulator
GE265_RS31840	COG3903	Transcriptional regulator
GE265_RS31840	COG3629	intracellular signal transduction
GE265_RS31855	COG0494	nUDIX hydrolase
GE265_RS31895	COG3409	Peptidoglycan-binding domain 1 protein
GE265_RS31910	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GE265_RS31925	COG2226	methyltransferase
GE265_RS31960	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS32005	COG0477	Major facilitator Superfamily
GE265_RS32085	COG2267	carboxylic ester hydrolase activity
GE265_RS32095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GE265_RS32110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE265_RS32120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GE265_RS32155	COG0698	ribose 5-phosphate isomerase
GE265_RS32185	COG0488	(ABC) transporter
GE265_RS32220	COG3757	hydrolase, family 25
GE265_RS32220	COG3409	Peptidoglycan-binding domain 1 protein
GE265_RS32240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GE265_RS32255	COG2124	cytochrome p450
GE265_RS32260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GE265_RS32320	COG1132	(ABC) transporter
GE265_RS32350	COG3397	chitin binding
GE265_RS32360	COG0789	Transcriptional regulator
GE265_RS32400	COG1011	Hydrolase
GE265_RS32410	COG2124	cytochrome p450
GE265_RS32455	COG1070	Carbohydrate kinase
GE265_RS32460	COG0277	FAD linked oxidase domain protein
GE265_RS32465	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS32470	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GE265_RS32505	COG3958	Transketolase
GE265_RS32510	COG3959	Transketolase, thiamine diphosphate binding domain
GE265_RS32595	COG2124	cytochrome p450
GE265_RS32635	COG0189	ligase activity
GE265_RS32665	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS32685	COG0464	growth
GE265_RS32745	COG2124	cytochrome p450
GE265_RS32750	COG1028	Short-chain dehydrogenase reductase Sdr
GE265_RS32765	COG2267	carboxylic ester hydrolase activity
GE265_RS32770	COG0640	Transcriptional regulator
GE265_RS32830	COG0484	heat shock protein binding
GE265_RS32870	COG0515	serine threonine protein kinase
GE265_RS32900	COG1131	(ABC) transporter
GE265_RS32925	COG0477	Major facilitator Superfamily
GE265_RS32930	COG1309	transcriptional regulator
GE265_RS32965	COG0488	(ABC) transporter
GE265_RS32990	COG3629	intracellular signal transduction
GE265_RS32990	COG3903	Transcriptional regulator
GE265_RS33005	COG0640	Transcriptional regulator
GE265_RS33130	COG2197	response regulator
GE265_RS33145	COG2124	cytochrome p450
GE265_RS33155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS33175	COG0596	Alpha beta hydrolase
GE265_RS33195	COG0156	8-amino-7-oxononanoate synthase activity
GE265_RS33200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GE265_RS33205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE265_RS33220	COG1733	regulation of RNA biosynthetic process
GE265_RS33225	COG0251	oxidation-reduction process
GE265_RS33245	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS33245	COG2319	Wd-40 repeat
GE265_RS33260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS33265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE265_RS33290	COG0531	amino acid
GE265_RS33350	COG0142	geranyltranstransferase activity
GE265_RS33395	COG0583	DNA-binding transcription factor activity
GE265_RS33405	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS33405	COG2319	Wd-40 repeat
GE265_RS33485	COG2409	Drug exporters of the RND superfamily
GE265_RS33500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GE265_RS33520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GE265_RS33560	COG1657	PFAM Prenyltransferase squalene oxidase
GE265_RS33565	COG2124	cytochrome p450
GE265_RS33575	COG0142	geranyltranstransferase activity
GE265_RS33615	COG1136	(ABC) transporter
GE265_RS33615	COG0577	efflux transmembrane transporter activity
GE265_RS33625	COG0586	Pfam SNARE associated Golgi protein
GE265_RS33635	COG2197	response regulator
GE265_RS33645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GE265_RS33655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GE265_RS33670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GE265_RS33695	COG1660	Displays ATPase and GTPase activities
GE265_RS33705	COG2816	NAD+ diphosphatase activity
GE265_RS33720	COG2267	carboxylic ester hydrolase activity
GE265_RS33750	COG2124	cytochrome p450
GE265_RS33855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GE265_RS33925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE265_RS33950	COG1132	(ABC) transporter
GE265_RS34005	COG3634	alkyl hydroperoxide reductase activity
GE265_RS34075	COG2319	Wd-40 repeat
GE265_RS34075	COG4249	Peptidase C14 caspase catalytic subunit p20
GE265_RS34085	COG4221	oxidoreductase activity
GE265_RS34150	COG0456	acetyltransferase
GE265_RS34260	COG2124	cytochrome p450
GE265_RS34330	COG1132	(ABC) transporter
GE265_RS34335	COG1132	(ABC) transporter
GE265_RS34340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS34370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS34380	COG0156	8-amino-7-oxononanoate synthase activity
GE265_RS34385	COG1960	acyl-CoA dehydrogenase activity
GE265_RS34395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS34410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GE265_RS34415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS34420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GE265_RS34430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GE265_RS34435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GE265_RS34490	COG0535	radical SAM domain protein
GE265_RS34500	COG0328	RNA-DNA hybrid ribonuclease activity
GE265_RS34720	COG2267	carboxylic ester hydrolase activity
GE265_RS34860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GE265_RS34920	COG2207	Transcriptional regulator
GE265_RS34930	COG3903	Transcriptional regulator
GE265_RS34930	COG3629	intracellular signal transduction
GE265_RS34960	COG2226	methyltransferase
GE265_RS35025	COG0792	nuclease activity
GE265_RS35135	COG1278	Cold shock
GE265_RS35210	COG0346	lactoylglutathione lyase activity
GE265_RS35330	COG3170	Tfp pilus assembly protein FimV
GE265_RS35335	COG2124	cytochrome p450
GE265_RS35350	COG0464	growth
GE265_RS35355	COG1404	Belongs to the peptidase S8 family
GE265_RS35360	COG1674	ftsk spoiiie
GE265_RS35430	COG2890	protein-(glutamine-N5) methyltransferase activity
GE265_RS35460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GE265_RS35480	COG0154	amidase activity
GE265_RS35485	COG2197	response regulator
GE265_RS35490	COG4585	Histidine kinase
GE265_RS35495	COG2409	Drug exporters of the RND superfamily
GE265_RS35505	COG1404	Belongs to the peptidase S8 family
GE265_RS35525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE265_RS35530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS35530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GE265_RS35545	COG1396	sequence-specific DNA binding
GE265_RS35545	COG3800	Transcriptional regulator
GE265_RS35550	COG2079	MmgE PrpD family protein
GE265_RS35555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GE265_RS35590	COG4106	trans-aconitate 2-methyltransferase activity