locus-tag	class	description
D1794_RS00080	COG0019	diaminopimelate decarboxylase activity
D1794_RS00085	COG4264	IucA IucC family
D1794_RS00105	COG0569	domain protein
D1794_RS00105	COG0475	glutathione-regulated potassium exporter activity
D1794_RS00130	COG2814	Major facilitator Superfamily
D1794_RS00155	COG1063	alcohol dehydrogenase
D1794_RS00160	COG0156	8-amino-7-oxononanoate synthase activity
D1794_RS00170	COG2018	Roadblock/LC7 domain
D1794_RS00185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1794_RS00210	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS00215	COG0531	amino acid
D1794_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS00240	COG0142	geranyltranstransferase activity
D1794_RS00260	COG2124	cytochrome p450
D1794_RS00295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1794_RS00310	COG1215	transferase activity, transferring glycosyl groups
D1794_RS00320	COG4310	Domain of unknown function (DUF2172)
D1794_RS00335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1794_RS00345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1794_RS00345	COG0438	transferase activity, transferring glycosyl groups
D1794_RS00380	COG0438	transferase activity, transferring glycosyl groups
D1794_RS00385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1794_RS00435	COG0473	3-isopropylmalate dehydrogenase activity
D1794_RS00485	COG1846	Transcriptional regulator
D1794_RS00500	COG0542	response to heat
D1794_RS00505	COG1366	Belongs to the anti-sigma-factor antagonist family
D1794_RS00505	COG2208	phosphoserine phosphatase activity
D1794_RS00505	COG2172	sigma factor antagonist activity
D1794_RS00520	COG1653	transport
D1794_RS00525	COG1233	COG1233 Phytoene dehydrogenase and related
D1794_RS00550	COG1233	COG1233 Phytoene dehydrogenase and related
D1794_RS00555	COG2130	NADP-dependent
D1794_RS00560	COG2376	Dihydroxyacetone kinase
D1794_RS00565	COG2376	Dihydroxyacetone kinase
D1794_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS00615	COG2124	cytochrome p450
D1794_RS00655	COG1124	(ABC) transporter
D1794_RS00660	COG0444	Belongs to the ABC transporter superfamily
D1794_RS00665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS00670	COG0601	transmembrane transport
D1794_RS00680	COG1960	acyl-CoA dehydrogenase activity
D1794_RS00685	COG1960	acyl-CoA dehydrogenase activity
D1794_RS00715	COG0517	IMP dehydrogenase activity
D1794_RS00715	COG1125	glycine betaine transport
D1794_RS00720	COG3458	cephalosporin-C deacetylase activity
D1794_RS00735	COG1174	glycine betaine transport
D1794_RS00750	COG1309	transcriptional regulator
D1794_RS00790	COG2124	cytochrome p450
D1794_RS00815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1794_RS00835	COG1024	Enoyl-CoA hydratase
D1794_RS00835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1794_RS00860	COG2124	cytochrome p450
D1794_RS00895	COG0463	Glycosyl transferase, family 2
D1794_RS00910	COG0402	S-adenosylhomocysteine deaminase activity
D1794_RS00930	COG1413	lyase activity
D1794_RS00950	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS00980	COG2326	polyphosphate kinase activity
D1794_RS00985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1794_RS01030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D1794_RS01035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D1794_RS01040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D1794_RS01090	COG0183	Belongs to the thiolase family
D1794_RS01115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1794_RS01120	COG1376	ErfK ybiS ycfS ynhG family protein
D1794_RS01140	COG0535	radical SAM domain protein
D1794_RS01150	COG3424	synthase
D1794_RS01160	COG3959	Transketolase, thiamine diphosphate binding domain
D1794_RS01195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1794_RS01200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1794_RS01290	COG1131	(ABC) transporter
D1794_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS01340	COG1309	transcriptional regulator
D1794_RS01375	COG3629	intracellular signal transduction
D1794_RS01375	COG3903	Transcriptional regulator
D1794_RS01380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1794_RS01385	COG1597	lipid kinase activity
D1794_RS01405	COG0574	Belongs to the PEP-utilizing enzyme family
D1794_RS01405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1794_RS01445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1794_RS01450	COG0477	Major facilitator Superfamily
D1794_RS01470	COG1174	glycine betaine transport
D1794_RS01475	COG1174	glycine betaine transport
D1794_RS01510	COG2957	Belongs to the agmatine deiminase family
D1794_RS01530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1794_RS01570	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1794_RS01580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1794_RS01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS01605	COG2207	Transcriptional regulator
D1794_RS01610	COG1120	ATPase activity
D1794_RS01615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D1794_RS01630	COG4552	Acetyltransferase involved in intracellular survival and related
D1794_RS01655	COG2197	response regulator
D1794_RS01660	COG0154	amidase activity
D1794_RS01670	COG0477	Major facilitator Superfamily
D1794_RS01675	COG0579	oxidoreductase
D1794_RS01695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D1794_RS01695	COG2755	lipolytic protein G-D-S-L family
D1794_RS01710	COG0745	RESPONSE REGULATOR receiver
D1794_RS01715	COG2205	protein histidine kinase activity
D1794_RS01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1794_RS01750	COG0477	Major facilitator Superfamily
D1794_RS01760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1794_RS01765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1794_RS01775	COG1609	Transcriptional regulator
D1794_RS01780	COG0596	Alpha beta hydrolase
D1794_RS01795	COG3572	ergothioneine biosynthetic process
D1794_RS01800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1794_RS01805	COG0121	glutamine amidotransferase
D1794_RS01810	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1794_RS01815	COG2182	Extracellular solute-binding protein
D1794_RS01820	COG3360	Dodecin
D1794_RS01830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1794_RS01850	COG5001	Diguanylate cyclase
D1794_RS01850	COG3300	MHYT domain
D1794_RS01905	COG3275	phosphorelay sensor kinase activity
D1794_RS01910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1794_RS01925	COG3279	Response regulator of the LytR AlgR family
D1794_RS01945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1794_RS01995	COG0297	glycogen (starch) synthase activity
D1794_RS02015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1794_RS02025	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1794_RS02035	COG3845	ABC transporter
D1794_RS02070	COG2205	protein histidine kinase activity
D1794_RS02075	COG0745	RESPONSE REGULATOR receiver
D1794_RS02105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1794_RS02125	COG0248	Ppx GppA phosphatase
D1794_RS02170	COG1175	transmembrane transport
D1794_RS02175	COG0395	ABC-type sugar transport system, permease component
D1794_RS02190	COG1051	belongs to the nudix hydrolase family
D1794_RS02195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1794_RS02205	COG2318	DinB family
D1794_RS02220	COG3251	PFAM MbtH domain protein
D1794_RS02225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1794_RS02235	COG0667	Aldo Keto reductase
D1794_RS02290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1794_RS02320	COG2072	flavoprotein involved in K transport
D1794_RS02345	COG1556	Lactate utilization protein
D1794_RS02350	COG1139	Iron-sulfur cluster binding protein
D1794_RS02355	COG0247	lactate metabolic process
D1794_RS02400	COG0438	transferase activity, transferring glycosyl groups
D1794_RS02430	COG0500	methyltransferase
D1794_RS02435	COG4981	capsule polysaccharide biosynthetic process
D1794_RS02490	COG0477	Major facilitator Superfamily
D1794_RS02510	COG2226	methyltransferase
D1794_RS02520	COG0187	DNA topoisomerase II activity
D1794_RS02560	COG0673	inositol 2-dehydrogenase activity
D1794_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS02610	COG2850	peptidyl-arginine hydroxylation
D1794_RS02665	COG3511	phospholipase C
D1794_RS02780	COG1960	acyl-CoA dehydrogenase activity
D1794_RS02830	COG1116	anion transmembrane transporter activity
D1794_RS02840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1794_RS02845	COG4948	Mandelate Racemase Muconate Lactonizing
D1794_RS02850	COG1960	acyl-CoA dehydrogenase activity
D1794_RS02885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1794_RS02890	COG1309	transcriptional regulator
D1794_RS02900	COG0741	lytic transglycosylase activity
D1794_RS02900	COG0739	heme binding
D1794_RS02900	COG1196	nuclear chromosome segregation
D1794_RS02910	COG2365	Tyrosine phosphatase family
D1794_RS02940	COG1657	PFAM Prenyltransferase squalene oxidase
D1794_RS02950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1794_RS02960	COG1562	ergosterol biosynthetic process
D1794_RS02965	COG1134	teichoic acid transport
D1794_RS02980	COG0371	Dehydrogenase
D1794_RS03005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1794_RS03040	COG2183	response to ionizing radiation
D1794_RS03055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1794_RS03065	COG2936	dipeptidyl-peptidase activity
D1794_RS03085	COG1024	Enoyl-CoA hydratase
D1794_RS03085	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1794_RS03090	COG0183	Belongs to the thiolase family
D1794_RS03095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1794_RS03100	COG3268	Saccharopine dehydrogenase
D1794_RS03105	COG1515	deoxyribonuclease V activity
D1794_RS03120	COG0488	(ABC) transporter
D1794_RS03125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1794_RS03165	COG1793	dna ligase
D1794_RS03220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1794_RS03265	COG3012	SEC-C Motif Domain Protein
D1794_RS03300	COG1609	Transcriptional regulator
D1794_RS03305	COG3345	alpha-galactosidase
D1794_RS03405	COG0475	glutathione-regulated potassium exporter activity
D1794_RS03420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D1794_RS03425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D1794_RS03430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D1794_RS03520	COG1082	Xylose isomerase domain protein TIM barrel
D1794_RS03545	COG0673	inositol 2-dehydrogenase activity
D1794_RS03550	COG4213	ABC transporter substrate-binding protein
D1794_RS03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1794_RS03560	COG1129	ABC transporter
D1794_RS03565	COG1940	carbohydrate kinase activity
D1794_RS03575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1794_RS03580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1794_RS03600	COG1595	DNA-templated transcription, initiation
D1794_RS03610	COG3250	beta-galactosidase activity
D1794_RS03620	COG3250	beta-galactosidase activity
D1794_RS03635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D1794_RS03640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1794_RS03650	COG0656	L-ascorbic acid biosynthetic process
D1794_RS03660	COG1793	dna ligase
D1794_RS03705	COG1063	alcohol dehydrogenase
D1794_RS03770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1794_RS03775	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1794_RS03785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1794_RS03790	COG2362	D-Aminopeptidase
D1794_RS03845	COG0604	alcohol dehydrogenase
D1794_RS03850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS03850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS03865	COG1960	acyl-CoA dehydrogenase activity
D1794_RS03870	COG0688	phosphatidylethanolamine metabolic process
D1794_RS03880	COG1929	Belongs to the glycerate kinase type-1 family
D1794_RS03895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1794_RS03900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1794_RS03910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1794_RS03925	COG0483	inositol monophosphate 1-phosphatase activity
D1794_RS03930	COG0095	Lipoate-protein ligase
D1794_RS03940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1794_RS03945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1794_RS03975	COG0405	Gamma-glutamyltransferase
D1794_RS03985	COG0765	amino acid transport
D1794_RS03990	COG0765	amino acid transport
D1794_RS03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1794_RS04000	COG1126	abc transporter atp-binding protein
D1794_RS04020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1794_RS04030	COG1940	carbohydrate kinase activity
D1794_RS04050	COG2188	Transcriptional regulator
D1794_RS04055	COG0673	inositol 2-dehydrogenase activity
D1794_RS04065	COG2197	response regulator
D1794_RS04070	COG4585	Histidine kinase
D1794_RS04085	COG4266	Belongs to the allantoicase family
D1794_RS04090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1794_RS04095	COG1414	Transcriptional regulator
D1794_RS04110	COG0746	molybdenum cofactor guanylyltransferase activity
D1794_RS04120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1794_RS04135	COG1288	antiporter activity
D1794_RS04165	COG2351	hydroxyisourate hydrolase activity
D1794_RS04190	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS04195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1794_RS04200	COG2197	response regulator
D1794_RS04215	COG3409	Peptidoglycan-binding domain 1 protein
D1794_RS04235	COG1404	Belongs to the peptidase S8 family
D1794_RS04250	COG0243	molybdopterin cofactor binding
D1794_RS04285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1794_RS04300	COG2345	Transcriptional regulator
D1794_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS04320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS04335	COG2197	response regulator
D1794_RS04340	COG1132	(ABC) transporter
D1794_RS04345	COG1132	(ABC) transporter
D1794_RS04355	COG0515	serine threonine protein kinase
D1794_RS04365	COG1609	Transcriptional regulator
D1794_RS04410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1794_RS04425	COG3835	regulator
D1794_RS04430	COG1840	ABC-type Fe3 transport system, periplasmic component
D1794_RS04440	COG3842	ATPase activity
D1794_RS04450	COG1802	Transcriptional regulator
D1794_RS04470	COG0028	Belongs to the TPP enzyme family
D1794_RS04500	COG1162	GTPase activity
D1794_RS04525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1794_RS04555	COG3290	protein histidine kinase activity
D1794_RS04595	COG1960	acyl-CoA dehydrogenase activity
D1794_RS04600	COG3284	Transcriptional regulator
D1794_RS04620	COG0175	sulfate reduction
D1794_RS04625	COG0529	Catalyzes the synthesis of activated sulfate
D1794_RS04645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1794_RS04650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1794_RS04685	COG1175	transmembrane transport
D1794_RS04760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1794_RS04765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1794_RS04790	COG1764	response to oxidative stress
D1794_RS04795	COG1846	Transcriptional regulator
D1794_RS04815	COG3220	belongs to the UPF0276 family
D1794_RS04835	COG0596	Alpha beta hydrolase
D1794_RS04840	COG3253	May function as heme-dependent peroxidase
D1794_RS04845	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1794_RS04855	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1794_RS04860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1794_RS04880	COG0183	Belongs to the thiolase family
D1794_RS04885	COG1024	Enoyl-CoA hydratase
D1794_RS04885	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1794_RS04895	COG0531	amino acid
D1794_RS04900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1794_RS04905	COG4214	carbohydrate transport
D1794_RS04915	COG4213	ABC transporter substrate-binding protein
D1794_RS04920	COG1940	carbohydrate kinase activity
D1794_RS04930	COG0395	ABC-type sugar transport system, permease component
D1794_RS04935	COG1175	transmembrane transport
D1794_RS04940	COG1653	transport
D1794_RS04955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1794_RS04960	COG1522	sequence-specific DNA binding
D1794_RS04980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1794_RS05025	COG1024	Enoyl-CoA hydratase
D1794_RS05030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1794_RS05040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1794_RS05060	COG2040	homocysteine
D1794_RS05080	COG1799	cell septum assembly
D1794_RS05100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1794_RS05120	COG4689	acetoacetate decarboxylase
D1794_RS05150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1794_RS05160	COG0745	RESPONSE REGULATOR receiver
D1794_RS05165	COG2205	protein histidine kinase activity
D1794_RS05190	COG0756	dUTP diphosphatase activity
D1794_RS05200	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1794_RS05200	COG1136	(ABC) transporter
D1794_RS05235	COG1136	(ABC) transporter
D1794_RS05235	COG0577	efflux transmembrane transporter activity
D1794_RS05245	COG0569	domain protein
D1794_RS05250	COG0531	amino acid
D1794_RS05255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1794_RS05270	COG0483	inositol monophosphate 1-phosphatase activity
D1794_RS05275	COG2264	protein methyltransferase activity
D1794_RS05290	COG0494	nUDIX hydrolase
D1794_RS05320	COG0142	geranyltranstransferase activity
D1794_RS05375	COG2409	Drug exporters of the RND superfamily
D1794_RS05400	COG3629	intracellular signal transduction
D1794_RS05400	COG3903	Transcriptional regulator
D1794_RS05410	COG2264	protein methyltransferase activity
D1794_RS05475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1794_RS05480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS05485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1794_RS05500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1794_RS05510	COG0702	epimerase
D1794_RS05525	COG1435	thymidine kinase activity
D1794_RS05540	COG0045	succinate-CoA ligase (ADP-forming) activity
D1794_RS05540	COG1042	CoA-binding domain protein
D1794_RS05540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1794_RS05545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1794_RS05550	COG1802	Transcriptional regulator
D1794_RS05555	COG0741	lytic transglycosylase activity
D1794_RS05555	COG0739	heme binding
D1794_RS05555	COG1196	nuclear chromosome segregation
D1794_RS05565	COG0612	Peptidase, M16
D1794_RS05570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1794_RS05580	COG0372	Belongs to the citrate synthase family
D1794_RS05590	COG3290	protein histidine kinase activity
D1794_RS05595	COG4565	transcriptional regulatory protein
D1794_RS05600	COG0187	DNA topoisomerase II activity
D1794_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1794_RS05620	COG2186	Transcriptional regulator
D1794_RS05625	COG1131	(ABC) transporter
D1794_RS05655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1794_RS05665	COG0406	alpha-ribazole phosphatase activity
D1794_RS05680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1794_RS05685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1794_RS05690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1794_RS05720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1794_RS05730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1794_RS05740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1794_RS05750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1794_RS05770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1794_RS05775	COG2358	TRAP transporter, solute receptor (TAXI family
D1794_RS05780	COG2205	protein histidine kinase activity
D1794_RS05785	COG0745	RESPONSE REGULATOR receiver
D1794_RS05790	COG1126	abc transporter atp-binding protein
D1794_RS05795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1794_RS05800	COG0765	amino acid transport
D1794_RS05805	COG0765	amino acid transport
D1794_RS05810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1794_RS05825	COG2137	regulation of response to DNA damage stimulus
D1794_RS05865	COG1201	RNA secondary structure unwinding
D1794_RS05870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1794_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS05885	COG0783	Belongs to the Dps family
D1794_RS05890	COG1396	sequence-specific DNA binding
D1794_RS05895	COG1546	Belongs to the CinA family
D1794_RS05895	COG1058	Belongs to the CinA family
D1794_RS05905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1794_RS05915	COG1674	ftsk spoiiie
D1794_RS05925	COG5002	protein histidine kinase activity
D1794_RS05925	COG0784	Response regulator, receiver
D1794_RS05930	COG2208	phosphoserine phosphatase activity
D1794_RS05930	COG2770	Histidine kinase
D1794_RS05960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1794_RS05965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1794_RS05970	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1794_RS05990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1794_RS05995	COG0612	Peptidase, M16
D1794_RS06000	COG1185	polyribonucleotide nucleotidyltransferase activity
D1794_RS06005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1794_RS06015	COG1674	ftsk spoiiie
D1794_RS06030	COG1404	Belongs to the peptidase S8 family
D1794_RS06045	COG1404	Belongs to the peptidase S8 family
D1794_RS06050	COG3266	domain, Protein
D1794_RS06070	COG0455	bacterial-type flagellum organization
D1794_RS06075	COG0747	negative chemotaxis
D1794_RS06085	COG0601	transmembrane transport
D1794_RS06090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS06110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1794_RS06115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1794_RS06125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1794_RS06140	COG0779	Required for maturation of 30S ribosomal subunits
D1794_RS06160	COG0442	prolyl-tRNA aminoacylation
D1794_RS06175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1794_RS06180	COG0750	zinc metalloprotease
D1794_RS06185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D1794_RS06200	COG2508	Transcriptional regulator
D1794_RS06230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1794_RS06235	COG1177	transmembrane transport
D1794_RS06240	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1794_RS06245	COG3842	ATPase activity
D1794_RS06270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1794_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS06295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS06300	COG1136	(ABC) transporter
D1794_RS06315	COG3842	ATPase activity
D1794_RS06330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1794_RS06335	COG0575	Belongs to the CDS family
D1794_RS06340	COG0233	cytoplasmic translational termination
D1794_RS06345	COG0528	UMP kinase activity
D1794_RS06350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1794_RS06355	COG0052	Belongs to the universal ribosomal protein uS2 family
D1794_RS06370	COG1191	sigma factor activity
D1794_RS06385	COG0792	nuclease activity
D1794_RS06400	COG0681	Belongs to the peptidase S26 family
D1794_RS06415	COG0681	Belongs to the peptidase S26 family
D1794_RS06420	COG0335	large ribosomal subunit rRNA binding
D1794_RS06425	COG0336	Belongs to the RNA methyltransferase TrmD family
D1794_RS06430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1794_RS06435	COG1837	Belongs to the UPF0109 family
D1794_RS06440	COG0228	four-way junction DNA binding
D1794_RS06455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1794_RS06465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D1794_RS06495	COG4552	Acetyltransferase involved in intracellular survival and related
D1794_RS06500	COG0477	Major facilitator Superfamily
D1794_RS06505	COG1196	nuclear chromosome segregation
D1794_RS06520	COG1254	Belongs to the acylphosphatase family
D1794_RS06525	COG2340	Cysteine-rich secretory protein family
D1794_RS06530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D1794_RS06535	COG0571	ribonuclease III activity
D1794_RS06540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1794_RS06555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1794_RS06560	COG0742	ribosomal rna small subunit methyltransferase
D1794_RS06570	COG1461	Dihydroxyacetone kinase
D1794_RS06575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1794_RS06580	COG0351	phosphomethylpyrimidine kinase
D1794_RS06595	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS06600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1794_RS06610	COG1920	GTP binding
D1794_RS06620	COG0776	regulation of translation
D1794_RS06630	COG0066	3-isopropylmalate dehydratase activity
D1794_RS06635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1794_RS06640	COG1414	Transcriptional regulator
D1794_RS06670	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D1794_RS06675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1794_RS06680	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1794_RS06685	COG5002	protein histidine kinase activity
D1794_RS06690	COG2018	Roadblock/LC7 domain
D1794_RS06710	COG2018	Roadblock/LC7 domain
D1794_RS06730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1794_RS06750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1794_RS06760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1794_RS06770	COG0477	Major facilitator Superfamily
D1794_RS06780	COG2957	Belongs to the agmatine deiminase family
D1794_RS06785	COG0804	urea catabolic process
D1794_RS06795	COG0831	urea catabolic process
D1794_RS06795	COG0832	Belongs to the urease beta subunit family
D1794_RS06820	COG0300	oxidoreductase activity
D1794_RS06830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1794_RS06855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1794_RS06860	COG0473	3-isopropylmalate dehydrogenase activity
D1794_RS06870	COG1082	Xylose isomerase domain protein TIM barrel
D1794_RS06880	COG1136	(ABC) transporter
D1794_RS06880	COG0577	efflux transmembrane transporter activity
D1794_RS06930	COG0640	Transcriptional regulator
D1794_RS06935	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS06940	COG0506	proline dehydrogenase activity
D1794_RS06945	COG2508	Transcriptional regulator
D1794_RS06945	COG2508	Transcriptional regulator
D1794_RS06950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1794_RS06955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1794_RS06960	COG0440	acetolactate synthase activity
D1794_RS06980	COG0667	Aldo Keto reductase
D1794_RS06985	COG2133	pyrroloquinoline quinone binding
D1794_RS06995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1794_RS06995	COG1672	PFAM Archaeal ATPase
D1794_RS07005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1794_RS07010	COG2409	Drug exporters of the RND superfamily
D1794_RS07020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1794_RS07030	COG0154	amidase activity
D1794_RS07035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1794_RS07045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1794_RS07055	COG4221	oxidoreductase activity
D1794_RS07060	COG1611	Belongs to the LOG family
D1794_RS07070	COG0482	sulfurtransferase activity
D1794_RS07100	COG2860	membrane
D1794_RS07105	COG4608	Belongs to the ABC transporter superfamily
D1794_RS07110	COG0444	Belongs to the ABC transporter superfamily
D1794_RS07115	COG0601	transmembrane transport
D1794_RS07120	COG0747	negative chemotaxis
D1794_RS07125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS07145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1794_RS07150	COG0509	glycine decarboxylation via glycine cleavage system
D1794_RS07155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1794_RS07160	COG1760	l-serine dehydratase
D1794_RS07170	COG2856	Zn peptidase
D1794_RS07300	COG1024	Enoyl-CoA hydratase
D1794_RS07315	COG1132	(ABC) transporter
D1794_RS07320	COG1132	(ABC) transporter
D1794_RS07330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1794_RS07360	COG2197	response regulator
D1794_RS07365	COG4585	Histidine kinase
D1794_RS07375	COG0058	SHG alpha-glucan phosphorylase activity
D1794_RS07380	COG0366	Alpha amylase catalytic
D1794_RS07385	COG0366	Alpha amylase catalytic
D1794_RS07395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1794_RS07410	COG1301	dicarboxylic acid transport
D1794_RS07415	COG3290	protein histidine kinase activity
D1794_RS07420	COG4565	transcriptional regulatory protein
D1794_RS07425	COG0181	hydroxymethylbilane synthase activity
D1794_RS07455	COG1175	transmembrane transport
D1794_RS07465	COG0205	6-phosphofructokinase activity
D1794_RS07470	COG0280	phosphate acetyltransferase
D1794_RS07470	COG0857	belongs to the CobB CobQ family
D1794_RS07475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1794_RS07510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS07510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS07555	COG0745	RESPONSE REGULATOR receiver
D1794_RS07570	COG0183	Belongs to the thiolase family
D1794_RS07590	COG1131	(ABC) transporter
D1794_RS07625	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1794_RS07640	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1794_RS07655	COG4585	Histidine kinase
D1794_RS07660	COG2197	response regulator
D1794_RS07670	COG1088	dTDP-glucose 4,6-dehydratase activity
D1794_RS07690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1794_RS07720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1794_RS07730	COG0494	nUDIX hydrolase
D1794_RS07745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1794_RS07750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1794_RS07755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1794_RS07760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1794_RS07765	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1794_RS07770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1794_RS07775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1794_RS07795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1794_RS07800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1794_RS07810	COG2890	protein-(glutamine-N5) methyltransferase activity
D1794_RS07815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1794_RS07820	COG0254	rRNA binding
D1794_RS07825	COG1316	TRANSCRIPTIONal
D1794_RS07840	COG0083	homoserine kinase activity
D1794_RS07845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1794_RS07850	COG0460	homoserine dehydrogenase
D1794_RS07855	COG0019	diaminopimelate decarboxylase activity
D1794_RS07860	COG0018	arginyl-trna synthetase
D1794_RS08010	COG2367	Beta-lactamase
D1794_RS08015	COG1686	Belongs to the peptidase S11 family
D1794_RS08025	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS08030	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
D1794_RS08035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1794_RS08055	COG2192	nodulation
D1794_RS08065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1794_RS08075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1794_RS08085	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
D1794_RS08090	COG0768	penicillin binding
D1794_RS08100	COG0367	asparagine synthase
D1794_RS08105	COG0010	Belongs to the arginase family
D1794_RS08110	COG2175	clavaminate synthase activity
D1794_RS08160	COG0697	spore germination
D1794_RS08165	COG0456	acetyltransferase
D1794_RS08170	COG0747	negative chemotaxis
D1794_RS08180	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS08185	COG0768	penicillin binding
D1794_RS08190	COG0768	penicillin binding
D1794_RS08195	COG2124	cytochrome p450
D1794_RS08205	COG2205	protein histidine kinase activity
D1794_RS08210	COG0745	RESPONSE REGULATOR receiver
D1794_RS08230	COG2072	flavoprotein involved in K transport
D1794_RS08235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D1794_RS08240	COG1793	dna ligase
D1794_RS08240	COG3285	dna ligase
D1794_RS08245	COG1793	dna ligase
D1794_RS08300	COG0768	penicillin binding
D1794_RS08330	COG2318	DinB family
D1794_RS08365	COG2205	protein histidine kinase activity
D1794_RS08385	COG1357	PFAM Pentapeptide repeats (8 copies)
D1794_RS08390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1794_RS08400	COG0745	RESPONSE REGULATOR receiver
D1794_RS08405	COG2205	protein histidine kinase activity
D1794_RS08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1794_RS08415	COG0567	Dehydrogenase, E1 component
D1794_RS08425	COG2255	four-way junction helicase activity
D1794_RS08460	COG0604	alcohol dehydrogenase
D1794_RS08480	COG1126	abc transporter atp-binding protein
D1794_RS08485	COG4106	trans-aconitate 2-methyltransferase activity
D1794_RS08505	COG0494	nUDIX hydrolase
D1794_RS08515	COG5640	endopeptidase activity
D1794_RS08535	COG0142	geranyltranstransferase activity
D1794_RS08570	COG1597	lipid kinase activity
D1794_RS08585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1794_RS08590	COG1472	Belongs to the glycosyl hydrolase 3 family
D1794_RS08595	COG0395	ABC-type sugar transport system, permease component
D1794_RS08600	COG1175	transmembrane transport
D1794_RS08605	COG2182	Extracellular solute-binding protein
D1794_RS08610	COG2188	Transcriptional regulator
D1794_RS08635	COG0242	peptide deformylase activity
D1794_RS08655	COG5662	AntiSigma factor
D1794_RS08660	COG1595	DNA-templated transcription, initiation
D1794_RS08670	COG2135	peptidase activity
D1794_RS08680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1794_RS08690	COG2076	Multidrug Resistance protein
D1794_RS08700	COG0483	inositol monophosphate 1-phosphatase activity
D1794_RS08710	COG0753	catalase activity
D1794_RS08735	COG1615	UPF0182 protein
D1794_RS08745	COG3480	Lon protease (S16) C-terminal proteolytic domain
D1794_RS08785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1794_RS08825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1794_RS08880	COG0601	transmembrane transport
D1794_RS08885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS08890	COG0747	negative chemotaxis
D1794_RS08900	COG0596	Alpha beta hydrolase
D1794_RS08900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1794_RS08930	COG0513	Belongs to the DEAD box helicase family
D1794_RS08955	COG1432	Conserved Protein
D1794_RS08960	COG2095	MarC family integral membrane protein
D1794_RS08985	COG0598	Magnesium transport protein CorA
D1794_RS09020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1794_RS09025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1794_RS09035	COG1595	DNA-templated transcription, initiation
D1794_RS09050	COG1024	Enoyl-CoA hydratase
D1794_RS09055	COG0519	Catalyzes the synthesis of GMP from XMP
D1794_RS09065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1794_RS09070	COG1611	Belongs to the LOG family
D1794_RS09075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1794_RS09120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1794_RS09135	COG4608	Belongs to the ABC transporter superfamily
D1794_RS09140	COG0444	Belongs to the ABC transporter superfamily
D1794_RS09145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS09150	COG0601	transmembrane transport
D1794_RS09165	COG4608	Belongs to the ABC transporter superfamily
D1794_RS09170	COG0444	Belongs to the ABC transporter superfamily
D1794_RS09180	COG4166	transmembrane transport
D1794_RS09185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1794_RS09195	COG1217	gtp-binding protein TYPA
D1794_RS09215	COG1053	succinate dehydrogenase
D1794_RS09265	COG0012	GTP binding
D1794_RS09280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1794_RS09285	COG0531	amino acid
D1794_RS09290	COG1570	exodeoxyribonuclease VII activity
D1794_RS09295	COG1722	exodeoxyribonuclease VII activity
D1794_RS09300	COG0778	Nitroreductase
D1794_RS09325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D1794_RS09325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D1794_RS09335	COG0114	fumarate hydratase activity
D1794_RS09355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1794_RS09375	COG1136	(ABC) transporter
D1794_RS09390	COG0450	alkyl hydroperoxide reductase
D1794_RS09395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1794_RS09410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1794_RS09415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1794_RS09420	COG0667	Aldo Keto reductase
D1794_RS09445	COG2885	chlorophyll binding
D1794_RS09465	COG2197	response regulator
D1794_RS09470	COG4585	Histidine kinase
D1794_RS09500	COG2894	cell division
D1794_RS09525	COG2610	gluconate transmembrane transporter activity
D1794_RS09530	COG0251	oxidation-reduction process
D1794_RS09535	COG1414	Transcriptional regulator
D1794_RS09550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D1794_RS09610	COG0492	ferredoxin-NADP+ reductase activity
D1794_RS09645	COG0728	peptidoglycan biosynthetic process
D1794_RS09655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1794_RS09660	COG0438	transferase activity, transferring glycosyl groups
D1794_RS09700	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1794_RS09710	COG1309	transcriptional regulator
D1794_RS09715	COG1331	Highly conserved protein containing a thioredoxin domain
D1794_RS09745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1794_RS09755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1794_RS09765	COG2188	Transcriptional regulator
D1794_RS09785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1794_RS09825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1794_RS09840	COG1064	alcohol dehydrogenase
D1794_RS09855	COG2986	histidine ammonia-lyase
D1794_RS09865	COG1024	Enoyl-CoA hydratase
D1794_RS09880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1794_RS09890	COG0424	maF-like protein
D1794_RS09895	COG4770	biotin carboxylase activity
D1794_RS09925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1794_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS09960	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS09975	COG1595	DNA-templated transcription, initiation
D1794_RS09980	COG0745	RESPONSE REGULATOR receiver
D1794_RS09985	COG2205	protein histidine kinase activity
D1794_RS10010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1794_RS10025	COG0583	DNA-binding transcription factor activity
D1794_RS10030	COG2814	Major facilitator Superfamily
D1794_RS10065	COG1079	Belongs to the binding-protein-dependent transport system permease family
D1794_RS10070	COG4603	Belongs to the binding-protein-dependent transport system permease family
D1794_RS10075	COG3845	ABC transporter
D1794_RS10080	COG1744	ABC transporter substrate-binding protein PnrA-like
D1794_RS10085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D1794_RS10085	COG1473	amidohydrolase
D1794_RS10095	COG2089	acid synthase
D1794_RS10100	COG1083	cytidylyl-transferase
D1794_RS10110	COG1216	Glycosyl transferase, family 2
D1794_RS10125	COG0516	GMP reductase activity
D1794_RS10125	COG0517	IMP dehydrogenase activity
D1794_RS10145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS10145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS10160	COG1595	DNA-templated transcription, initiation
D1794_RS10170	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1794_RS10175	COG2009	succinate dehydrogenase
D1794_RS10185	COG1053	succinate dehydrogenase
D1794_RS10190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1794_RS10200	COG1408	metallophosphoesterase
D1794_RS10210	COG1686	Belongs to the peptidase S11 family
D1794_RS10215	COG1295	ribonuclease BN
D1794_RS10220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1794_RS10245	COG0180	Tryptophanyl-tRNA synthetase
D1794_RS10250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1794_RS10255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1794_RS10260	COG0754	glutathionylspermidine amidase activity
D1794_RS10270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1794_RS10310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1794_RS10320	COG0039	L-malate dehydrogenase activity
D1794_RS10335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1794_RS10350	COG0138	bifunctional purine biosynthesis protein purh
D1794_RS10380	COG0045	succinate-CoA ligase (ADP-forming) activity
D1794_RS10385	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D1794_RS10395	COG0714	Associated with various cellular activities
D1794_RS10410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS10410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1794_RS10420	COG0739	heme binding
D1794_RS10440	COG2197	response regulator
D1794_RS10465	COG0519	Catalyzes the synthesis of GMP from XMP
D1794_RS10465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1794_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS10505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1794_RS10515	COG0516	GMP reductase activity
D1794_RS10525	COG1595	DNA-templated transcription, initiation
D1794_RS10530	COG2197	response regulator
D1794_RS10540	COG0583	DNA-binding transcription factor activity
D1794_RS10555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1794_RS10560	COG0459	protein refolding
D1794_RS10565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1794_RS10570	COG0726	polysaccharide deacetylase
D1794_RS10580	COG4941	Belongs to the sigma-70 factor family
D1794_RS10605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1794_RS10630	COG0802	atpase or kinase
D1794_RS10640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1794_RS10660	COG0736	holo-[acyl-carrier-protein] synthase activity
D1794_RS10665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1794_RS10670	COG1072	(Pantothenic acid kinase))
D1794_RS10675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1794_RS10680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1794_RS10685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1794_RS10690	COG0488	(ABC) transporter
D1794_RS10700	COG0101	tRNA pseudouridine synthase activity
D1794_RS10705	COG0203	ribosomal protein L17
D1794_RS10710	COG0202	RNA polymerase activity
D1794_RS10715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1794_RS10720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1794_RS10725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1794_RS10730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1794_RS10740	COG0563	adenylate kinase activity
D1794_RS10750	COG0200	Binds to the 23S rRNA
D1794_RS10755	COG1841	ribosomal large subunit assembly
D1794_RS10760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1794_RS10765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1794_RS10770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1794_RS10775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1794_RS10785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1794_RS10790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1794_RS10795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1794_RS10800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1794_RS10805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1794_RS10810	COG0255	Belongs to the universal ribosomal protein uL29 family
D1794_RS10815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1794_RS10820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1794_RS10825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1794_RS10830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1794_RS10835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1794_RS10840	COG0089	rRNA binding
D1794_RS10845	COG0088	Forms part of the polypeptide exit tunnel
D1794_RS10850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1794_RS10855	COG0051	transcription antitermination factor activity, RNA binding
D1794_RS10865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1794_RS10870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1794_RS10875	COG0049	tRNA binding
D1794_RS10880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1794_RS10890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1794_RS10895	COG0085	RNA polymerase activity
D1794_RS10905	COG0222	ribosome binding
D1794_RS10910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1794_RS10915	COG0081	regulation of translation
D1794_RS10920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1794_RS10930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1794_RS10940	COG0436	Aminotransferase
D1794_RS10945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1794_RS10950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1794_RS10960	COG2030	dehydratase
D1794_RS10965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1794_RS10985	COG0702	epimerase
D1794_RS11005	COG1666	GTP binding
D1794_RS11010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1794_RS11020	COG3304	Inner membrane component domain
D1794_RS11025	COG0501	Belongs to the peptidase M48B family
D1794_RS11030	COG1007	ATP synthesis coupled electron transport
D1794_RS11045	COG0713	ATP synthesis coupled electron transport
D1794_RS11050	COG0839	Belongs to the complex I subunit 6 family
D1794_RS11055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1794_RS11065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11080	COG4585	Histidine kinase
D1794_RS11095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1794_RS11095	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1794_RS11100	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1794_RS11125	COG1733	regulation of RNA biosynthetic process
D1794_RS11140	COG2234	aminopeptidase activity
D1794_RS11140	COG4935	Belongs to the peptidase S8 family
D1794_RS11165	COG0142	geranyltranstransferase activity
D1794_RS11170	COG2936	dipeptidyl-peptidase activity
D1794_RS11175	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1794_RS11180	COG1007	ATP synthesis coupled electron transport
D1794_RS11190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1794_RS11195	COG0713	ATP synthesis coupled electron transport
D1794_RS11200	COG0839	Belongs to the complex I subunit 6 family
D1794_RS11205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1794_RS11215	COG1034	ATP synthesis coupled electron transport
D1794_RS11220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D1794_RS11230	COG0649	NAD binding
D1794_RS11235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1794_RS11270	COG2226	methyltransferase
D1794_RS11280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1794_RS11285	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1794_RS11295	COG1278	Cold shock
D1794_RS11300	COG1823	symporter activity
D1794_RS11315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1794_RS11325	COG0163	prenyltransferase activity
D1794_RS11330	COG0109	protoheme IX farnesyltransferase activity
D1794_RS11335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1794_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1794_RS11350	COG1333	cytochrome c biogenesis protein
D1794_RS11355	COG0785	Cytochrome C biogenesis protein
D1794_RS11360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1794_RS11365	COG0406	alpha-ribazole phosphatase activity
D1794_RS11370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1794_RS11385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1794_RS11395	COG1742	UPF0060 membrane protein
D1794_RS11410	COG0402	S-adenosylhomocysteine deaminase activity
D1794_RS11415	COG1690	Belongs to the RtcB family
D1794_RS11455	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D1794_RS11460	COG0626	cystathionine gamma-synthase activity
D1794_RS11475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D1794_RS11480	COG0018	arginyl-trna synthetase
D1794_RS11500	COG0113	porphobilinogen synthase activity
D1794_RS11605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D1794_RS11610	COG0596	Alpha beta hydrolase
D1794_RS11635	COG1136	(ABC) transporter
D1794_RS11720	COG1725	Transcriptional regulator
D1794_RS11750	COG1309	transcriptional regulator
D1794_RS11770	COG0702	epimerase
D1794_RS11780	COG1960	acyl-CoA dehydrogenase activity
D1794_RS11805	COG0259	pyridoxamine-phosphate oxidase activity
D1794_RS11820	COG2072	flavoprotein involved in K transport
D1794_RS11830	COG1024	Enoyl-CoA hydratase
D1794_RS11840	COG0456	acetyltransferase
D1794_RS11845	COG0477	Major facilitator Superfamily
D1794_RS11845	COG2814	Major facilitator Superfamily
D1794_RS11850	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS11865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1794_RS11870	COG2271	Major facilitator Superfamily
D1794_RS11875	COG4977	sequence-specific DNA binding
D1794_RS11875	COG1917	Cupin 2, conserved barrel domain protein
D1794_RS11885	COG1960	acyl-CoA dehydrogenase activity
D1794_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS11905	COG1960	acyl-CoA dehydrogenase activity
D1794_RS11910	COG1960	acyl-CoA dehydrogenase activity
D1794_RS11920	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS11925	COG3397	chitin binding
D1794_RS11995	COG2945	thiolester hydrolase activity
D1794_RS11995	COG0596	Alpha beta hydrolase
D1794_RS12005	COG4821	SIS domain
D1794_RS12015	COG0259	pyridoxamine-phosphate oxidase activity
D1794_RS12035	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS12050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1794_RS12115	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS12160	COG0726	polysaccharide deacetylase
D1794_RS12195	COG0577	efflux transmembrane transporter activity
D1794_RS12200	COG1136	(ABC) transporter
D1794_RS12200	COG0577	efflux transmembrane transporter activity
D1794_RS12240	COG0583	DNA-binding transcription factor activity
D1794_RS12265	COG2205	protein histidine kinase activity
D1794_RS12270	COG0745	RESPONSE REGULATOR receiver
D1794_RS12285	COG0277	FAD linked oxidase domain protein
D1794_RS12285	COG0247	lactate metabolic process
D1794_RS12295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1794_RS12335	COG0463	Glycosyl transferase, family 2
D1794_RS12350	COG3903	Transcriptional regulator
D1794_RS12350	COG3629	intracellular signal transduction
D1794_RS12365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1794_RS12405	COG1122	ATPase activity
D1794_RS12425	COG0667	Aldo Keto reductase
D1794_RS12460	COG2252	PERMEase
D1794_RS12470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1794_RS12500	COG2814	Major facilitator Superfamily
D1794_RS12510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1794_RS12515	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D1794_RS12520	COG1278	Cold shock
D1794_RS12555	COG1061	Type III restriction enzyme res subunit
D1794_RS12565	COG3973	AAA domain
D1794_RS12580	COG1595	DNA-templated transcription, initiation
D1794_RS12660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1794_RS12665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1794_RS12675	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS12680	COG1605	Chorismate mutase
D1794_RS12700	COG2197	response regulator
D1794_RS12720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1794_RS12745	COG0191	fructose-bisphosphate aldolase activity
D1794_RS12750	COG1105	Belongs to the carbohydrate kinase PfkB family
D1794_RS12765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1794_RS12770	COG2182	Extracellular solute-binding protein
D1794_RS12795	COG0463	Glycosyl transferase, family 2
D1794_RS12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1794_RS12890	COG3842	ATPase activity
D1794_RS12900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1794_RS12910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1794_RS12915	COG0215	cysteine-tRNA ligase activity
D1794_RS12925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1794_RS12930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1794_RS12935	COG1329	Transcriptional regulator
D1794_RS12955	COG5002	protein histidine kinase activity
D1794_RS12965	COG0588	phosphoglycerate mutase activity
D1794_RS12970	COG2211	Major facilitator Superfamily
D1794_RS12995	COG0438	transferase activity, transferring glycosyl groups
D1794_RS13055	COG1490	D-aminoacyl-tRNA deacylase activity
D1794_RS13070	COG3485	protocatechuate 3,4-dioxygenase
D1794_RS13100	COG1309	transcriptional regulator
D1794_RS13120	COG0745	RESPONSE REGULATOR receiver
D1794_RS13125	COG1609	Transcriptional regulator
D1794_RS13140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1794_RS13160	COG2188	Transcriptional regulator
D1794_RS13170	COG1525	nuclease
D1794_RS13170	COG0737	Belongs to the 5'-nucleotidase family
D1794_RS13170	COG4085	toxin activity
D1794_RS13190	COG0456	acetyltransferase
D1794_RS13195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1794_RS13205	COG0494	nUDIX hydrolase
D1794_RS13205	COG0406	alpha-ribazole phosphatase activity
D1794_RS13230	COG0306	phosphate transporter
D1794_RS13240	COG1937	Protein conserved in bacteria
D1794_RS13260	COG0671	phosphoesterase, PA-phosphatase related
D1794_RS13265	COG1196	nuclear chromosome segregation
D1794_RS13265	COG0741	lytic transglycosylase activity
D1794_RS13265	COG0739	heme binding
D1794_RS13365	COG0579	oxidoreductase
D1794_RS13370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1794_RS13380	COG1196	nuclear chromosome segregation
D1794_RS13380	COG0741	lytic transglycosylase activity
D1794_RS13380	COG0739	heme binding
D1794_RS13435	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1794_RS13445	COG0513	Belongs to the DEAD box helicase family
D1794_RS13455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1794_RS13460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1794_RS13495	COG0785	Cytochrome C biogenesis protein
D1794_RS13500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1794_RS13500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1794_RS13510	COG1643	Atp-dependent helicase
D1794_RS13545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1794_RS13575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1794_RS13580	COG0047	phosphoribosylformylglycinamidine synthase activity
D1794_RS13585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1794_RS13620	COG2197	response regulator
D1794_RS13630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1794_RS13645	COG0151	Belongs to the GarS family
D1794_RS13675	COG0017	Asparaginyl-tRNA synthetase
D1794_RS13680	COG1051	belongs to the nudix hydrolase family
D1794_RS13690	COG0105	UTP biosynthetic process
D1794_RS13730	COG2826	transposase and inactivated derivatives, IS30 family
D1794_RS13765	COG3903	Transcriptional regulator
D1794_RS13765	COG3629	intracellular signal transduction
D1794_RS13830	COG0477	Major facilitator Superfamily
D1794_RS13860	COG2234	aminopeptidase activity
D1794_RS13865	COG0433	COG0433 Predicted ATPase
D1794_RS13880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1794_RS13920	COG1191	sigma factor activity
D1794_RS13925	COG1191	sigma factor activity
D1794_RS13975	COG2304	oxidoreductase activity
D1794_RS13980	COG2205	protein histidine kinase activity
D1794_RS13985	COG0745	RESPONSE REGULATOR receiver
D1794_RS13990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1794_RS14015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1794_RS14045	COG3250	beta-galactosidase activity
D1794_RS14050	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS14085	COG3250	beta-galactosidase activity
D1794_RS14090	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS14125	COG1960	acyl-CoA dehydrogenase activity
D1794_RS14135	COG1362	aminopeptidase activity
D1794_RS14155	COG2271	Major facilitator Superfamily
D1794_RS14170	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1794_RS14175	COG0022	dehydrogenase e1 component
D1794_RS14200	COG0515	serine threonine protein kinase
D1794_RS14205	COG0515	serine threonine protein kinase
D1794_RS14220	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1794_RS14220	COG1136	(ABC) transporter
D1794_RS14250	COG0303	'Molybdopterin
D1794_RS14275	COG1522	sequence-specific DNA binding
D1794_RS14280	COG1309	transcriptional regulator
D1794_RS14285	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1794_RS14310	COG3396	Phenylacetate-CoA oxygenase
D1794_RS14315	COG3460	Phenylacetate-CoA oxygenase
D1794_RS14320	COG3396	Phenylacetate-CoA oxygenase
D1794_RS14325	COG2151	metal-sulfur cluster biosynthetic enzyme
D1794_RS14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1794_RS14335	COG1960	acyl-CoA dehydrogenase activity
D1794_RS14340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1794_RS14355	COG2197	response regulator
D1794_RS14360	COG4585	Histidine kinase
D1794_RS14385	COG0577	efflux transmembrane transporter activity
D1794_RS14385	COG1136	(ABC) transporter
D1794_RS14390	COG0577	efflux transmembrane transporter activity
D1794_RS14390	COG1136	(ABC) transporter
D1794_RS14400	COG1716	ATPase activity
D1794_RS14405	COG1716	ATPase activity
D1794_RS14420	COG0768	penicillin binding
D1794_RS14425	COG0515	serine threonine protein kinase
D1794_RS14430	COG3764	Sortase (surface protein transpeptidase)
D1794_RS14435	COG3764	Sortase (surface protein transpeptidase)
D1794_RS14450	COG3764	Sortase (surface protein transpeptidase)
D1794_RS14465	COG0457	Tetratricopeptide repeat
D1794_RS14465	COG0705	Rhomboid family
D1794_RS14500	COG1446	asparaginase
D1794_RS14505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1794_RS14510	COG1280	lysine exporter protein (LysE YggA)
D1794_RS14515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1794_RS14515	COG1672	PFAM Archaeal ATPase
D1794_RS14530	COG0667	Aldo Keto reductase
D1794_RS14535	COG2175	clavaminate synthase activity
D1794_RS14540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1794_RS14545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS14550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS14565	COG0515	serine threonine protein kinase
D1794_RS14585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1794_RS14595	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D1794_RS14600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1794_RS14605	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D1794_RS14610	COG0592	DNA-directed DNA polymerase activity
D1794_RS14625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1794_RS14630	COG0594	ribonuclease P activity
D1794_RS14635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1794_RS14640	COG0706	membrane insertase activity
D1794_RS14650	COG0357	Ribosomal RNA small subunit methyltransferase G
D1794_RS14655	COG1192	Involved in chromosome partitioning
D1794_RS14670	COG3118	belongs to the thioredoxin family
D1794_RS14675	COG0492	ferredoxin-NADP+ reductase activity
D1794_RS14685	COG1595	DNA-templated transcription, initiation
D1794_RS14690	COG2815	serine threonine protein kinase
D1794_RS14690	COG0515	serine threonine protein kinase
D1794_RS14705	COG0617	tRNA 3'-terminal CCA addition
D1794_RS14730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1794_RS14755	COG0360	Binds together with S18 to 16S ribosomal RNA
D1794_RS14760	COG0629	single-stranded DNA binding
D1794_RS14765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1794_RS14770	COG0359	binds to the 23S rRNA
D1794_RS14780	COG0305	Participates in initiation and elongation during chromosome replication
D1794_RS14815	COG0626	cystathionine gamma-synthase activity
D1794_RS14820	COG1950	PFAM Membrane protein of
D1794_RS14825	COG0662	Cupin 2, conserved barrel domain protein
D1794_RS14845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1794_RS14860	COG1609	Transcriptional regulator
D1794_RS14865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1794_RS14870	COG1271	oxidase subunit
D1794_RS14875	COG1294	oxidase, subunit
D1794_RS14880	COG4988	ABC transporter
D1794_RS14890	COG0561	phosphatase activity
D1794_RS14900	COG1131	(ABC) transporter
D1794_RS14935	COG0561	phosphatase activity
D1794_RS14940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1794_RS14945	COG0077	Prephenate dehydratase
D1794_RS14950	COG2837	iron assimilation
D1794_RS14965	COG1999	signal sequence binding
D1794_RS14985	COG0006	proline dipeptidase activity
D1794_RS15015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1794_RS15055	COG0587	DNA-directed DNA polymerase activity
D1794_RS15060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1794_RS15085	COG1595	DNA-templated transcription, initiation
D1794_RS15090	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS15095	COG0784	Response regulator, receiver
D1794_RS15125	COG0745	RESPONSE REGULATOR receiver
D1794_RS15130	COG0477	Major facilitator Superfamily
D1794_RS15150	COG0431	NADPH-dependent FMN reductase
D1794_RS15180	COG1672	PFAM Archaeal ATPase
D1794_RS15180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1794_RS15185	COG0431	NADPH-dependent FMN reductase
D1794_RS15215	COG0598	Magnesium transport protein CorA
D1794_RS15220	COG3345	alpha-galactosidase
D1794_RS15295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D1794_RS15305	COG2226	methyltransferase
D1794_RS15310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1794_RS15355	COG2826	transposase and inactivated derivatives, IS30 family
D1794_RS15470	COG1857	crispr-associated protein
D1794_RS15490	COG0436	Aminotransferase
D1794_RS15500	COG2197	response regulator
D1794_RS15510	COG0577	efflux transmembrane transporter activity
D1794_RS15575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1794_RS15600	COG3629	intracellular signal transduction
D1794_RS15600	COG3903	Transcriptional regulator
D1794_RS15645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1794_RS15655	COG0534	Mate efflux family protein
D1794_RS15660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1794_RS15665	COG0019	diaminopimelate decarboxylase activity
D1794_RS15680	COG4166	transmembrane transport
D1794_RS15685	COG0601	transmembrane transport
D1794_RS15690	COG4171	peptide transport system, permease
D1794_RS15705	COG2197	response regulator
D1794_RS15710	COG4585	Histidine kinase
D1794_RS15715	COG2409	Drug exporters of the RND superfamily
D1794_RS15740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1794_RS15750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1794_RS15755	COG0588	phosphoglycerate mutase activity
D1794_RS15805	COG0717	Belongs to the dCTP deaminase family
D1794_RS15820	COG0247	lactate metabolic process
D1794_RS15820	COG2181	nitrate reductase activity
D1794_RS15825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1794_RS15830	COG0443	Heat shock 70 kDa protein
D1794_RS15835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1794_RS15840	COG0484	heat shock protein binding
D1794_RS15845	COG0789	Transcriptional regulator
D1794_RS15865	COG0542	response to heat
D1794_RS15895	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1794_RS15910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1794_RS15915	COG0191	fructose-bisphosphate aldolase activity
D1794_RS15920	COG0477	Major facilitator Superfamily
D1794_RS15955	COG4585	Histidine kinase
D1794_RS15965	COG2124	cytochrome p450
D1794_RS16000	COG0463	Glycosyl transferase, family 2
D1794_RS16005	COG1802	Transcriptional regulator
D1794_RS16025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS16060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1794_RS16075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1794_RS16080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1794_RS16095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1794_RS16100	COG1595	DNA-templated transcription, initiation
D1794_RS16130	COG2124	cytochrome p450
D1794_RS16145	COG2091	lysine biosynthetic process via aminoadipic acid
D1794_RS16160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D1794_RS16190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1794_RS16270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1794_RS16290	COG1408	metallophosphoesterase
D1794_RS16295	COG1610	YqeY-like protein
D1794_RS16300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1794_RS16315	COG0003	Pfam Anion-transporting ATPase
D1794_RS16345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1794_RS16375	COG2267	carboxylic ester hydrolase activity
D1794_RS16385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1794_RS16390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1794_RS16395	COG0659	secondary active sulfate transmembrane transporter activity
D1794_RS16455	COG1111	helicase
D1794_RS16455	COG1205	dead DEAH box helicase
D1794_RS16460	COG1366	Belongs to the anti-sigma-factor antagonist family
D1794_RS16465	COG2172	sigma factor antagonist activity
D1794_RS16470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1794_RS16480	COG2890	protein-(glutamine-N5) methyltransferase activity
D1794_RS16490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1794_RS16490	COG1754	DNA topoisomerase type I activity
D1794_RS16500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1794_RS16505	COG0470	DNA polymerase III
D1794_RS16515	COG0477	Major facilitator Superfamily
D1794_RS16555	COG1061	Type III restriction enzyme res subunit
D1794_RS16600	COG0791	NLP P60 protein
D1794_RS16670	COG0305	Participates in initiation and elongation during chromosome replication
D1794_RS16835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1794_RS16950	COG1132	(ABC) transporter
D1794_RS16955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1794_RS16955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1794_RS16960	COG0110	maltose O-acetyltransferase activity
D1794_RS17005	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS17010	COG2318	DinB family
D1794_RS17025	COG0076	glutamate decarboxylase activity
D1794_RS17040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1794_RS17045	COG2027	D-alanyl-D-alanine carboxypeptidase
D1794_RS17055	COG0037	tRNA processing
D1794_RS17070	COG0302	gtp cyclohydrolase
D1794_RS17085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1794_RS17110	COG1174	glycine betaine transport
D1794_RS17125	COG0649	NAD binding
D1794_RS17140	COG2197	response regulator
D1794_RS17155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1794_RS17160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1794_RS17170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1794_RS17190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1794_RS17215	COG2027	D-alanyl-D-alanine carboxypeptidase
D1794_RS17225	COG0739	heme binding
D1794_RS17230	COG2205	protein histidine kinase activity
D1794_RS17235	COG0745	RESPONSE REGULATOR receiver
D1794_RS17245	COG1595	DNA-templated transcription, initiation
D1794_RS17250	COG1194	a g-specific adenine glycosylase
D1794_RS17255	COG0671	phosphoesterase, PA-phosphatase related
D1794_RS17270	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D1794_RS17290	COG0248	Ppx GppA phosphatase
D1794_RS17300	COG0129	dihydroxy-acid dehydratase activity
D1794_RS17320	COG2226	methyltransferase
D1794_RS17325	COG1595	DNA-templated transcription, initiation
D1794_RS17330	COG1252	NADH dehydrogenase
D1794_RS17335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1794_RS17340	COG0180	Tryptophanyl-tRNA synthetase
D1794_RS17370	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1794_RS17405	COG1595	DNA-templated transcription, initiation
D1794_RS17420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D1794_RS17425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1794_RS17430	COG0181	hydroxymethylbilane synthase activity
D1794_RS17435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1794_RS17435	COG1648	precorrin-2 dehydrogenase activity
D1794_RS17460	COG1846	Transcriptional regulator
D1794_RS17465	COG3384	dioxygenase
D1794_RS17485	COG0477	Major facilitator Superfamily
D1794_RS17495	COG3191	aminopeptidase activity
D1794_RS17510	COG1970	mechanosensitive ion channel activity
D1794_RS17520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1794_RS17550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1794_RS17560	COG0315	cyclic pyranopterin monophosphate synthase activity
D1794_RS17565	COG0315	cyclic pyranopterin monophosphate synthase activity
D1794_RS17565	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1794_RS17570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1794_RS17615	COG2072	flavoprotein involved in K transport
D1794_RS17620	COG2267	carboxylic ester hydrolase activity
D1794_RS17625	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS17630	COG0793	Belongs to the peptidase S41A family
D1794_RS17630	COG4946	Tricorn protease homolog
D1794_RS17640	COG2409	Drug exporters of the RND superfamily
D1794_RS17650	COG0310	cobalt ion transport
D1794_RS17660	COG1122	ATPase activity
D1794_RS17665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1794_RS17705	COG0124	histidyl-tRNA synthetase
D1794_RS17730	COG3409	Peptidoglycan-binding domain 1 protein
D1794_RS17735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1794_RS17755	COG0442	prolyl-tRNA aminoacylation
D1794_RS17795	COG0084	hydrolase, TatD family'
D1794_RS17805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1794_RS17810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1794_RS17840	COG0488	(ABC) transporter
D1794_RS17870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1794_RS17875	COG2197	response regulator
D1794_RS17885	COG4106	trans-aconitate 2-methyltransferase activity
D1794_RS17890	COG1309	transcriptional regulator
D1794_RS17900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1794_RS17910	COG0193	aminoacyl-tRNA hydrolase activity
D1794_RS17915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1794_RS17920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1794_RS17925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1794_RS17935	COG4585	Histidine kinase
D1794_RS17965	COG0477	Major facilitator Superfamily
D1794_RS17980	COG1136	(ABC) transporter
D1794_RS17985	COG0577	efflux transmembrane transporter activity
D1794_RS17990	COG1595	DNA-templated transcription, initiation
D1794_RS18015	COG0515	serine threonine protein kinase
D1794_RS18015	COG2815	serine threonine protein kinase
D1794_RS18045	COG1652	LysM domain
D1794_RS18060	COG0148	phosphopyruvate hydratase activity
D1794_RS18080	COG1252	NADH dehydrogenase
D1794_RS18085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1794_RS18095	COG0577	efflux transmembrane transporter activity
D1794_RS18095	COG1136	(ABC) transporter
D1794_RS18100	COG0577	efflux transmembrane transporter activity
D1794_RS18100	COG1136	(ABC) transporter
D1794_RS18130	COG0183	Belongs to the thiolase family
D1794_RS18135	COG2755	lipolytic protein G-D-S-L family
D1794_RS18150	COG1737	Transcriptional regulator
D1794_RS18210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1794_RS18240	COG1228	amidohydrolase
D1794_RS18265	COG1191	sigma factor activity
D1794_RS18290	COG3104	oligopeptide transport
D1794_RS18295	COG0745	RESPONSE REGULATOR receiver
D1794_RS18300	COG2205	protein histidine kinase activity
D1794_RS18335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D1794_RS18430	COG1309	transcriptional regulator
D1794_RS18435	COG0596	Alpha beta hydrolase
D1794_RS18440	COG1316	TRANSCRIPTIONal
D1794_RS18445	COG1607	acyl-coa hydrolase
D1794_RS18450	COG1316	TRANSCRIPTIONal
D1794_RS18470	COG1316	TRANSCRIPTIONal
D1794_RS18495	COG0778	Nitroreductase
D1794_RS18495	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D1794_RS18500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1794_RS18545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1794_RS18550	COG2835	tetraacyldisaccharide 4'-kinase activity
D1794_RS18560	COG1482	cell wall glycoprotein biosynthetic process
D1794_RS18575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1794_RS18605	COG2826	transposase and inactivated derivatives, IS30 family
D1794_RS18615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1794_RS18620	COG0745	RESPONSE REGULATOR receiver
D1794_RS18625	COG5000	phosphorelay sensor kinase activity
D1794_RS18625	COG5002	protein histidine kinase activity
D1794_RS18630	COG0823	Involved in the tonB-independent uptake of proteins
D1794_RS18640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1794_RS18645	COG2197	response regulator
D1794_RS18650	COG3214	Protein conserved in bacteria
D1794_RS18660	COG0653	protein targeting
D1794_RS18685	COG2902	Dehydrogenase
D1794_RS18695	COG0395	ABC-type sugar transport system, permease component
D1794_RS18700	COG1175	transmembrane transport
D1794_RS18715	COG0515	serine threonine protein kinase
D1794_RS18720	COG0515	serine threonine protein kinase
D1794_RS18725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1794_RS18735	COG2884	Cell division ATP-binding protein ftsE
D1794_RS18745	COG0793	Belongs to the peptidase S41A family
D1794_RS18750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1794_RS18765	COG0583	DNA-binding transcription factor activity
D1794_RS18790	COG3973	AAA domain
D1794_RS18800	COG0776	regulation of translation
D1794_RS18805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1794_RS18810	COG1678	Uncharacterized ACR, COG1678
D1794_RS18825	COG1175	transmembrane transport
D1794_RS18830	COG0395	ABC-type sugar transport system, permease component
D1794_RS18835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1794_RS18875	COG3654	unkown
D1794_RS18900	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1794_RS18905	COG0745	RESPONSE REGULATOR receiver
D1794_RS18910	COG5002	protein histidine kinase activity
D1794_RS18930	COG0277	FAD linked oxidase domain protein
D1794_RS18970	COG1335	isochorismatase
D1794_RS18980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D1794_RS18990	COG1113	amino acid transport
D1794_RS19000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1794_RS19005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS19010	COG1120	ATPase activity
D1794_RS19025	COG1234	tRNA 3'-trailer cleavage
D1794_RS19030	COG1263	PTS System
D1794_RS19035	COG1263	PTS System
D1794_RS19045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1794_RS19050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1794_RS19060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1794_RS19090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1794_RS19105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1794_RS19130	COG2733	membrane
D1794_RS19160	COG0706	membrane insertase activity
D1794_RS19170	COG0673	inositol 2-dehydrogenase activity
D1794_RS19250	COG1126	abc transporter atp-binding protein
D1794_RS19255	COG0765	amino acid transport
D1794_RS19260	COG0765	amino acid transport
D1794_RS19270	COG0154	amidase activity
D1794_RS19280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS19315	COG0406	alpha-ribazole phosphatase activity
D1794_RS19355	COG0745	RESPONSE REGULATOR receiver
D1794_RS19370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1794_RS19375	COG4977	sequence-specific DNA binding
D1794_RS19385	COG0589	response to stress
D1794_RS19390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1794_RS19415	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1794_RS19420	COG0076	glutamate decarboxylase activity
D1794_RS19430	COG1960	acyl-CoA dehydrogenase activity
D1794_RS19445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1794_RS19450	COG1309	transcriptional regulator
D1794_RS19460	COG2124	cytochrome p450
D1794_RS19465	COG1946	Acyl-CoA thioesterase
D1794_RS19480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1794_RS19490	COG3960	tartronate-semialdehyde synthase activity
D1794_RS19510	COG1674	ftsk spoiiie
D1794_RS19570	COG1472	Belongs to the glycosyl hydrolase 3 family
D1794_RS19585	COG1609	Transcriptional regulator
D1794_RS19590	COG0673	inositol 2-dehydrogenase activity
D1794_RS19605	COG1595	DNA-templated transcription, initiation
D1794_RS19615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1794_RS19640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1794_RS19650	COG3718	enzyme involved in inositol metabolism
D1794_RS19655	COG3962	Belongs to the TPP enzyme family
D1794_RS19675	COG1131	(ABC) transporter
D1794_RS19730	COG0105	UTP biosynthetic process
D1794_RS19735	COG2197	response regulator
D1794_RS19745	COG2954	triphosphatase activity
D1794_RS19755	COG0494	nUDIX hydrolase
D1794_RS19785	COG0561	phosphatase activity
D1794_RS19795	COG0475	glutathione-regulated potassium exporter activity
D1794_RS19825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1794_RS19835	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D1794_RS19840	COG1518	maintenance of DNA repeat elements
D1794_RS19850	COG1203	CRISPR-associated helicase, Cas3
D1794_RS19890	COG0629	single-stranded DNA binding
D1794_RS19920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1794_RS19965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1794_RS19980	COG1486	melibiose metabolic process
D1794_RS19985	COG0395	ABC-type sugar transport system, permease component
D1794_RS19990	COG1175	transmembrane transport
D1794_RS20010	COG0668	transmembrane transport
D1794_RS20080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1794_RS20085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1794_RS20095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1794_RS20105	COG0588	phosphoglycerate mutase activity
D1794_RS20110	COG1113	amino acid transport
D1794_RS20120	COG1113	amino acid transport
D1794_RS20135	COG4552	Acetyltransferase involved in intracellular survival and related
D1794_RS20150	COG0475	glutathione-regulated potassium exporter activity
D1794_RS20165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1794_RS20170	COG3594	Acyltransferase
D1794_RS20190	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1794_RS20195	COG0740	serine-type endopeptidase activity
D1794_RS20200	COG0740	serine-type endopeptidase activity
D1794_RS20205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1794_RS20215	COG0525	valine-tRNA ligase activity
D1794_RS20220	COG4585	Histidine kinase
D1794_RS20225	COG0285	dihydrofolate synthase activity
D1794_RS20235	COG0105	UTP biosynthetic process
D1794_RS20240	COG1077	Cell shape determining protein MreB Mrl
D1794_RS20260	COG0772	Belongs to the SEDS family
D1794_RS20280	COG1530	ribonuclease E activity
D1794_RS20290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1794_RS20295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1794_RS20300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1794_RS20305	COG0438	transferase activity, transferring glycosyl groups
D1794_RS20320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1794_RS20330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1794_RS20345	COG0501	Belongs to the peptidase M48B family
D1794_RS20350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1794_RS20360	COG0799	negative regulation of ribosome biogenesis
D1794_RS20365	COG0588	phosphoglycerate mutase activity
D1794_RS20380	COG0495	leucyl-tRNA aminoacylation
D1794_RS20390	COG1307	EDD domain protein, DegV family
D1794_RS20425	COG0268	Binds directly to 16S ribosomal RNA
D1794_RS20430	COG0481	GTPase activity
D1794_RS20455	COG1420	regulation of RNA biosynthetic process
D1794_RS20460	COG0484	heat shock protein binding
D1794_RS20480	COG4946	Tricorn protease homolog
D1794_RS20480	COG0793	Belongs to the peptidase S41A family
D1794_RS20485	COG0537	adenosine 5'-monophosphoramidase activity
D1794_RS20490	COG1234	tRNA 3'-trailer cleavage
D1794_RS20495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1794_RS20500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1794_RS20510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1794_RS20550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1794_RS20570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1794_RS20585	COG1381	Involved in DNA repair and RecF pathway recombination
D1794_RS20590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1794_RS20600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1794_RS20605	COG1121	(ABC) transporter
D1794_RS20610	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1794_RS20610	COG3443	Belongs to the bacterial solute-binding protein 9 family
D1794_RS20615	COG0423	glycine-tRNA ligase activity
D1794_RS20655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1794_RS20655	COG0574	Belongs to the PEP-utilizing enzyme family
D1794_RS20670	COG0531	amino acid
D1794_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS20685	COG2890	protein-(glutamine-N5) methyltransferase activity
D1794_RS20705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1794_RS20725	COG2949	membrane
D1794_RS20730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1794_RS20740	COG0358	DNA primase activity
D1794_RS20745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1794_RS20760	COG1070	Carbohydrate kinase
D1794_RS20795	COG1129	ABC transporter
D1794_RS20795	COG0842	Transport permease protein
D1794_RS20850	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS20860	COG1136	(ABC) transporter
D1794_RS20915	COG2130	NADP-dependent
D1794_RS20950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1794_RS20955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1794_RS20960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1794_RS20985	COG0789	Transcriptional regulator
D1794_RS20990	COG0667	Aldo Keto reductase
D1794_RS20995	COG2197	response regulator
D1794_RS21000	COG4585	Histidine kinase
D1794_RS21020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1794_RS21025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1794_RS21070	COG1358	cellular component organization or biogenesis
D1794_RS21080	COG0586	Pfam SNARE associated Golgi protein
D1794_RS21105	COG0582	viral genome integration into host DNA
D1794_RS21220	COG4122	O-methyltransferase activity
D1794_RS21230	COG2124	cytochrome p450
D1794_RS21235	COG0183	Belongs to the thiolase family
D1794_RS21250	COG3845	ABC transporter
D1794_RS21285	COG1309	transcriptional regulator
D1794_RS21290	COG0438	transferase activity, transferring glycosyl groups
D1794_RS21295	COG2226	methyltransferase
D1794_RS21305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS21325	COG0183	Belongs to the thiolase family
D1794_RS21345	COG2030	dehydratase
D1794_RS21350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1794_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS21365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1794_RS21385	COG0800	Aldolase
D1794_RS21390	COG3022	response to hydroperoxide
D1794_RS21405	COG0789	Transcriptional regulator
D1794_RS21425	COG1349	DNA-binding transcription factor activity
D1794_RS21430	COG1653	transport
D1794_RS21440	COG0395	ABC-type sugar transport system, permease component
D1794_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS21490	COG3540	Alkaline phosphatase
D1794_RS21495	COG2814	Major facilitator Superfamily
D1794_RS21510	COG1834	amidinotransferase
D1794_RS21530	COG1120	ATPase activity
D1794_RS21535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS21565	COG5398	heme oxygenase
D1794_RS21595	COG1994	Peptidase M50
D1794_RS21615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1794_RS21625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1794_RS21625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1794_RS21630	COG2132	Multicopper oxidase
D1794_RS21665	COG0174	glutamine synthetase
D1794_RS21680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1794_RS21695	COG1228	amidohydrolase
D1794_RS21710	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1794_RS21715	COG0494	nUDIX hydrolase
D1794_RS21735	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1794_RS21755	COG1609	Transcriptional regulator
D1794_RS21760	COG0366	Alpha amylase catalytic
D1794_RS21765	COG3833	ABC-type maltose transport systems, permease component
D1794_RS21770	COG1175	transmembrane transport
D1794_RS21800	COG2197	response regulator
D1794_RS21840	COG0745	RESPONSE REGULATOR receiver
D1794_RS21850	COG0673	inositol 2-dehydrogenase activity
D1794_RS21875	COG0181	hydroxymethylbilane synthase activity
D1794_RS21930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1794_RS21935	COG0321	lipoyl(octanoyl) transferase activity
D1794_RS21950	COG1090	epimerase
D1794_RS21980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1794_RS21990	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1794_RS21995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1794_RS22000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1794_RS22005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1794_RS22015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1794_RS22045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1794_RS22050	COG1132	(ABC) transporter
D1794_RS22075	COG4585	Histidine kinase
D1794_RS22080	COG2197	response regulator
D1794_RS22085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1794_RS22095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1794_RS22115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1794_RS22125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1794_RS22130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1794_RS22140	COG1376	ErfK ybiS ycfS ynhG family protein
D1794_RS22150	COG1845	cytochrome c oxidase, subunit III
D1794_RS22155	COG2010	Cytochrome c
D1794_RS22160	COG0723	plastoquinol--plastocyanin reductase activity
D1794_RS22165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1794_RS22170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1794_RS22175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1794_RS22180	COG1929	Belongs to the glycerate kinase type-1 family
D1794_RS22190	COG0745	RESPONSE REGULATOR receiver
D1794_RS22195	COG2205	protein histidine kinase activity
D1794_RS22250	COG0438	transferase activity, transferring glycosyl groups
D1794_RS22275	COG0003	Pfam Anion-transporting ATPase
D1794_RS22285	COG1940	carbohydrate kinase activity
D1794_RS22315	COG2197	response regulator
D1794_RS22320	COG0205	6-phosphofructokinase activity
D1794_RS22330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D1794_RS22335	COG0243	molybdopterin cofactor binding
D1794_RS22340	COG2193	ferroxidase activity
D1794_RS22345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1794_RS22350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D1794_RS22355	COG0515	serine threonine protein kinase
D1794_RS22355	COG2815	serine threonine protein kinase
D1794_RS22360	COG2022	thiamine diphosphate biosynthetic process
D1794_RS22370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1794_RS22370	COG2022	thiamine diphosphate biosynthetic process
D1794_RS22390	COG0352	thiamine-phosphate diphosphorylase activity
D1794_RS22405	COG1233	COG1233 Phytoene dehydrogenase and related
D1794_RS22415	COG1309	transcriptional regulator
D1794_RS22420	COG1511	domain protein
D1794_RS22425	COG1121	(ABC) transporter
D1794_RS22455	COG0714	Associated with various cellular activities
D1794_RS22470	COG0275	rRNA processing
D1794_RS22480	COG0768	penicillin binding
D1794_RS22485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1794_RS22490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1794_RS22495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1794_RS22500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1794_RS22510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1794_RS22515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1794_RS22525	COG1496	oxidoreductase activity
D1794_RS22535	COG1799	cell septum assembly
D1794_RS22545	COG3599	regulation of cell shape
D1794_RS22550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1794_RS22560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1794_RS22610	COG0587	DNA-directed DNA polymerase activity
D1794_RS22615	COG1432	Conserved Protein
D1794_RS22635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1794_RS22655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1794_RS22660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1794_RS22665	COG0131	Imidazoleglycerol-phosphate dehydratase
D1794_RS22670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1794_RS22675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1794_RS22680	COG0251	oxidation-reduction process
D1794_RS22685	COG0107	imidazoleglycerol-phosphate synthase activity
D1794_RS22700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1794_RS22705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1794_RS22725	COG0134	indole-3-glycerol-phosphate synthase activity
D1794_RS22735	COG0133	tryptophan synthase activity
D1794_RS22740	COG0159	tryptophan synthase activity
D1794_RS22750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1794_RS22755	COG2301	Belongs to the HpcH HpaI aldolase family
D1794_RS22760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1794_RS22765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1794_RS22805	COG0070	glutamate synthase
D1794_RS22805	COG0067	glutamate synthase
D1794_RS22805	COG0069	glutamate synthase activity
D1794_RS22830	COG1960	acyl-CoA dehydrogenase activity
D1794_RS22840	COG1309	transcriptional regulator
D1794_RS22845	COG0183	Belongs to the thiolase family
D1794_RS22875	COG1024	Enoyl-CoA hydratase
D1794_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS22900	COG1470	cell adhesion involved in biofilm formation
D1794_RS22900	COG0366	Alpha amylase catalytic
D1794_RS22915	COG1605	Chorismate mutase
D1794_RS22915	COG0287	Prephenate dehydrogenase
D1794_RS22975	COG0411	ABC transporter
D1794_RS22995	COG2050	protein possibly involved in aromatic compounds catabolism
D1794_RS23025	COG1643	Atp-dependent helicase
D1794_RS23030	COG2226	methyltransferase
D1794_RS23030	COG0596	Alpha beta hydrolase
D1794_RS23030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1794_RS23035	COG0539	negative regulation of cytoplasmic translation
D1794_RS23045	COG0237	dephospho-CoA kinase activity
D1794_RS23065	COG0330	HflC and HflK could
D1794_RS23070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1794_RS23100	COG2313	pseudouridylate synthase activity
D1794_RS23110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1794_RS23115	COG0584	glycerophosphoryl diester phosphodiesterase
D1794_RS23125	COG0556	nucleotide-excision repair
D1794_RS23145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1794_RS23155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1794_RS23160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1794_RS23160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1794_RS23185	COG0322	excinuclease ABC activity
D1794_RS23190	COG1660	Displays ATPase and GTPase activities
D1794_RS23195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1794_RS23200	COG1481	regulation of sporulation
D1794_RS23215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1794_RS23220	COG0126	phosphoglycerate kinase activity
D1794_RS23225	COG0149	triose-phosphate isomerase activity
D1794_RS23230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1794_RS23240	COG0166	Belongs to the GPI family
D1794_RS23245	COG3402	PFAM membrane-flanked domain
D1794_RS23255	COG0363	glucosamine-6-phosphate deaminase activity
D1794_RS23270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1794_RS23280	COG0109	protoheme IX farnesyltransferase activity
D1794_RS23310	COG1131	(ABC) transporter
D1794_RS23325	COG0719	Fe-S assembly protein
D1794_RS23335	COG0396	ATPase activity
D1794_RS23340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1794_RS23345	COG0822	iron-sulfur transferase activity
D1794_RS23350	COG2151	metal-sulfur cluster biosynthetic enzyme
D1794_RS23355	COG2171	N-acyltransferase activity
D1794_RS23365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1794_RS23415	COG2205	protein histidine kinase activity
D1794_RS23420	COG0745	RESPONSE REGULATOR receiver
D1794_RS23440	COG1802	Transcriptional regulator
D1794_RS23455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1794_RS23460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1794_RS23470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1794_RS23480	COG0768	penicillin binding
D1794_RS23485	COG2197	response regulator
D1794_RS23490	COG4585	Histidine kinase
D1794_RS23495	COG1414	Transcriptional regulator
D1794_RS23520	COG1902	pentaerythritol trinitrate reductase activity
D1794_RS23525	COG5285	phytanoyl-CoA dioxygenase
D1794_RS23530	COG1917	Cupin 2, conserved barrel domain protein
D1794_RS23545	COG0134	indole-3-glycerol-phosphate synthase activity
D1794_RS23580	COG1797	cobyrinic acid a,c-diamide synthase activity
D1794_RS23595	COG1492	cobalamin metabolic process
D1794_RS23600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1794_RS23615	COG0235	Class ii aldolase
D1794_RS23630	COG0488	(ABC) transporter
D1794_RS23640	COG1024	Enoyl-CoA hydratase
D1794_RS23680	COG3387	PFAM Glycoside hydrolase 15-related
D1794_RS23715	COG1404	Belongs to the peptidase S8 family
D1794_RS23725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1794_RS23730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1794_RS23750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1794_RS23765	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS23770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1794_RS23780	COG2186	Transcriptional regulator
D1794_RS23785	COG2807	transmembrane transport
D1794_RS23800	COG3830	Belongs to the UPF0237 family
D1794_RS23800	COG0560	Phosphoserine phosphatase
D1794_RS23805	COG0842	Transport permease protein
D1794_RS23805	COG1131	(ABC) transporter
D1794_RS23805	COG1716	ATPase activity
D1794_RS23815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1794_RS23825	COG4585	Histidine kinase
D1794_RS23830	COG2197	response regulator
D1794_RS23845	COG1119	ATPase activity
D1794_RS23870	COG1881	PFAM PEBP family protein
D1794_RS23880	COG2094	Belongs to the DNA glycosylase MPG family
D1794_RS23920	COG0647	UMP catabolic process
D1794_RS23925	COG1120	ATPase activity
D1794_RS23945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1794_RS23950	COG0497	DNA recombination
D1794_RS23955	COG0297	glycogen (starch) synthase activity
D1794_RS23965	COG3387	PFAM Glycoside hydrolase 15-related
D1794_RS23970	COG0504	CTP synthase activity
D1794_RS23975	COG0494	nUDIX hydrolase
D1794_RS23985	COG0686	Belongs to the AlaDH PNT family
D1794_RS24000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D1794_RS24005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D1794_RS24010	COG1187	pseudouridine synthase activity
D1794_RS24015	COG1051	belongs to the nudix hydrolase family
D1794_RS24015	COG1056	cytidyltransferase-related domain
D1794_RS24040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1794_RS24050	COG1160	GTP binding
D1794_RS24070	COG0438	transferase activity, transferring glycosyl groups
D1794_RS24080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1794_RS24090	COG0671	phosphoesterase, PA-phosphatase related
D1794_RS24095	COG0477	Major facilitator Superfamily
D1794_RS24100	COG1960	acyl-CoA dehydrogenase activity
D1794_RS24105	COG1799	cell septum assembly
D1794_RS24165	COG3903	Transcriptional regulator
D1794_RS24165	COG3629	intracellular signal transduction
D1794_RS24170	COG0596	Alpha beta hydrolase
D1794_RS24195	COG4565	transcriptional regulatory protein
D1794_RS24220	COG1725	Transcriptional regulator
D1794_RS24235	COG2755	lipolytic protein G-D-S-L family
D1794_RS24245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1794_RS24250	COG2188	Transcriptional regulator
D1794_RS24255	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1794_RS24260	COG2851	Citrate transporter
D1794_RS24295	COG3876	Protein conserved in bacteria
D1794_RS24310	COG1960	acyl-CoA dehydrogenase activity
D1794_RS24325	COG2149	membrane
D1794_RS24345	COG3265	gluconokinase activity
D1794_RS24350	COG2186	Transcriptional regulator
D1794_RS24355	COG1113	amino acid transport
D1794_RS24385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1794_RS24415	COG0667	Aldo Keto reductase
D1794_RS24420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS24430	COG0598	Magnesium transport protein CorA
D1794_RS24450	COG0215	cysteine-tRNA ligase activity
D1794_RS24460	COG4948	Mandelate Racemase Muconate Lactonizing
D1794_RS24465	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS24475	COG1129	ABC transporter
D1794_RS24485	COG2186	Transcriptional regulator
D1794_RS24490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1794_RS24495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1794_RS24500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1794_RS24505	COG1414	Transcriptional regulator
D1794_RS24510	COG1410	methionine synthase
D1794_RS24510	COG0646	methionine synthase
D1794_RS24515	COG0438	transferase activity, transferring glycosyl groups
D1794_RS24530	COG2197	response regulator
D1794_RS24540	COG0517	IMP dehydrogenase activity
D1794_RS24540	COG1994	Peptidase M50
D1794_RS24565	COG1222	aaa ATPase
D1794_RS24570	COG4122	O-methyltransferase activity
D1794_RS24585	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1794_RS24590	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1794_RS24595	COG1609	Transcriptional regulator
D1794_RS24605	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1794_RS24640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1794_RS24645	COG0805	protein transport
D1794_RS24680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1794_RS24685	COG0517	IMP dehydrogenase activity
D1794_RS24685	COG4175	Glycine betaine
D1794_RS24705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1794_RS24710	COG1113	amino acid transport
D1794_RS24715	COG2186	Transcriptional regulator
D1794_RS24720	COG0174	glutamine synthetase
D1794_RS24745	COG1404	Belongs to the peptidase S8 family
D1794_RS24765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1794_RS24770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1794_RS24775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1794_RS24780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1794_RS24785	COG5002	protein histidine kinase activity
D1794_RS24790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1794_RS24795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1794_RS24795	COG0072	phenylalanine-tRNA ligase activity
D1794_RS24815	COG1649	PFAM Uncharacterised BCR, COG1649
D1794_RS24825	COG0697	spore germination
D1794_RS24835	COG2838	Isocitrate dehydrogenase
D1794_RS24865	COG4585	Histidine kinase
D1794_RS24870	COG2197	response regulator
D1794_RS24875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1794_RS24880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1794_RS24885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1794_RS24890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1794_RS24895	COG1438	arginine binding
D1794_RS24900	COG0137	argininosuccinate synthase activity
D1794_RS24905	COG0165	Argininosuccinate lyase
D1794_RS24915	COG0477	Major facilitator Superfamily
D1794_RS24920	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS24920	COG0204	Acyl-transferase
D1794_RS24925	COG0584	glycerophosphoryl diester phosphodiesterase
D1794_RS24945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1794_RS24950	COG2011	ABC-type metal ion transport system permease component
D1794_RS24955	COG1464	Belongs to the NlpA lipoprotein family
D1794_RS24970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1794_RS24980	COG1648	precorrin-2 dehydrogenase activity
D1794_RS24980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1794_RS25025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1794_RS25035	COG0456	acetyltransferase
D1794_RS25080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1794_RS25085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1794_RS25090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1794_RS25115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1794_RS25120	COG1560	Kdo2-lipid A biosynthetic process
D1794_RS25125	COG0438	transferase activity, transferring glycosyl groups
D1794_RS25135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1794_RS25140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1794_RS25145	COG0217	transcriptional regulatory protein
D1794_RS25150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1794_RS25155	COG0632	four-way junction helicase activity
D1794_RS25160	COG2255	four-way junction helicase activity
D1794_RS25170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1794_RS25175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1794_RS25180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1794_RS25185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1794_RS25195	COG1196	nuclear chromosome segregation
D1794_RS25200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1794_RS25210	COG0124	histidyl-tRNA synthetase
D1794_RS25230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1794_RS25245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1794_RS25250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1794_RS25255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1794_RS25260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1794_RS25265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1794_RS25270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1794_RS25275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1794_RS25280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1794_RS25290	COG0006	proline dipeptidase activity
D1794_RS25295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1794_RS25300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1794_RS25310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1794_RS25315	COG0540	Belongs to the ATCase OTCase family
D1794_RS25320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1794_RS25330	COG0505	Belongs to the CarA family
D1794_RS25335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1794_RS25340	COG0167	dihydroorotate dehydrogenase activity
D1794_RS25345	COG0284	orotidine-5'-phosphate decarboxylase activity
D1794_RS25370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1794_RS25395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1794_RS25405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1794_RS25410	COG2390	Transcriptional regulator
D1794_RS25440	COG1191	sigma factor activity
D1794_RS25450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1794_RS25465	COG2233	PERMEase
D1794_RS25475	COG0738	Major facilitator superfamily
D1794_RS25480	COG1846	Transcriptional regulator
D1794_RS25480	COG1940	carbohydrate kinase activity
D1794_RS25495	COG3201	nicotinamide mononucleotide transporter
D1794_RS25500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1794_RS25500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1794_RS25505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1794_RS25510	COG0140	phosphoribosyl-ATP diphosphatase activity
D1794_RS25515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1794_RS25555	COG1309	transcriptional regulator
D1794_RS25560	COG1960	acyl-CoA dehydrogenase activity
D1794_RS25580	COG1216	Glycosyl transferase, family 2
D1794_RS25595	COG2270	Major facilitator Superfamily
D1794_RS25605	COG2364	Membrane
D1794_RS25610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1794_RS25640	COG1984	allophanate hydrolase subunit 2
D1794_RS25645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1794_RS25650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D1794_RS25655	COG2814	Major facilitator Superfamily
D1794_RS25685	COG5002	protein histidine kinase activity
D1794_RS25690	COG2018	Roadblock/LC7 domain
D1794_RS25705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1794_RS25710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1794_RS25715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1794_RS25735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1794_RS25745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1794_RS25775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1794_RS25795	COG1716	ATPase activity
D1794_RS25815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1794_RS25825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1794_RS25825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1794_RS25895	COG0697	spore germination
D1794_RS25955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1794_RS25975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1794_RS25985	COG2813	Specifically methylates the guanine in position
D1794_RS26000	COG1968	undecaprenyl-diphosphatase activity
D1794_RS26015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1794_RS26040	COG2124	cytochrome p450
D1794_RS26070	COG0110	maltose O-acetyltransferase activity
D1794_RS26075	COG1832	CoA-binding protein
D1794_RS26080	COG1739	Uncharacterized protein family UPF0029
D1794_RS26090	COG0666	response to abiotic stimulus
D1794_RS26095	COG0420	3'-5' exonuclease activity
D1794_RS26100	COG0419	ATPase involved in DNA repair
D1794_RS26100	COG0419	ATPase involved in DNA repair
D1794_RS26105	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS26135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1794_RS26150	COG2188	Transcriptional regulator
D1794_RS26155	COG1940	carbohydrate kinase activity
D1794_RS26165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1794_RS26200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1794_RS26205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS26210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1794_RS26230	COG0740	serine-type endopeptidase activity
D1794_RS26240	COG0831	urea catabolic process
D1794_RS26245	COG0832	Belongs to the urease beta subunit family
D1794_RS26250	COG0804	urea catabolic process
D1794_RS26265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1794_RS26270	COG0829	nickel cation binding
D1794_RS26280	COG0204	Acyl-transferase
D1794_RS26295	COG0142	geranyltranstransferase activity
D1794_RS26300	COG0142	geranyltranstransferase activity
D1794_RS26315	COG0205	6-phosphofructokinase activity
D1794_RS26320	COG3442	glutamine amidotransferase
D1794_RS26330	COG0242	peptide deformylase activity
D1794_RS26340	COG1960	acyl-CoA dehydrogenase activity
D1794_RS26365	COG0386	Belongs to the glutathione peroxidase family
D1794_RS26370	COG1946	Acyl-CoA thioesterase
D1794_RS26390	COG1132	(ABC) transporter
D1794_RS26390	COG2375	cellular response to nickel ion
D1794_RS26395	COG1132	(ABC) transporter
D1794_RS26405	COG2409	Drug exporters of the RND superfamily
D1794_RS26420	COG2124	cytochrome p450
D1794_RS26430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1794_RS26440	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS26455	COG0477	Major facilitator Superfamily
D1794_RS26485	COG4585	Histidine kinase
D1794_RS26490	COG2197	response regulator
D1794_RS26510	COG2409	Drug exporters of the RND superfamily
D1794_RS26520	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1794_RS26520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1794_RS26525	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1794_RS26575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1794_RS26580	COG0604	alcohol dehydrogenase
D1794_RS26580	COG3321	synthase
D1794_RS26595	COG1960	acyl-CoA dehydrogenase activity
D1794_RS26615	COG1132	(ABC) transporter
D1794_RS26620	COG2072	flavoprotein involved in K transport
D1794_RS26685	COG0443	Heat shock 70 kDa protein
D1794_RS26700	COG1309	transcriptional regulator
D1794_RS26710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS26715	COG1902	pentaerythritol trinitrate reductase activity
D1794_RS26775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1794_RS26825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS26830	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS26835	COG1120	ATPase activity
D1794_RS26845	COG1132	(ABC) transporter
D1794_RS26870	COG4607	ABC-type enterochelin transport system periplasmic component
D1794_RS26875	COG0464	growth
D1794_RS26880	COG1404	Belongs to the peptidase S8 family
D1794_RS26885	COG1674	ftsk spoiiie
D1794_RS26950	COG1278	Cold shock
D1794_RS26965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1794_RS26975	COG1136	(ABC) transporter
D1794_RS26975	COG0577	efflux transmembrane transporter activity
D1794_RS26980	COG1136	(ABC) transporter
D1794_RS26980	COG0577	efflux transmembrane transporter activity
D1794_RS26995	COG0745	RESPONSE REGULATOR receiver
D1794_RS27000	COG2205	protein histidine kinase activity
D1794_RS27035	COG0463	Glycosyl transferase, family 2
D1794_RS27040	COG0326	Molecular chaperone. Has ATPase activity
D1794_RS27080	COG0309	Hydrogenase expression formation protein (HypE)
D1794_RS27090	COG0298	carbon dioxide binding
D1794_RS27100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1794_RS27105	COG0375	protein maturation
D1794_RS27190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1794_RS27225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1794_RS27240	COG2706	6-phosphogluconolactonase activity
D1794_RS27255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1794_RS27285	COG1309	transcriptional regulator
D1794_RS27290	COG0671	phosphoesterase, PA-phosphatase related
D1794_RS27315	COG0584	glycerophosphoryl diester phosphodiesterase
D1794_RS27335	COG0204	Acyl-transferase
D1794_RS27350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1794_RS27370	COG3345	alpha-galactosidase
D1794_RS27380	COG1175	transmembrane transport
D1794_RS27385	COG0395	ABC-type sugar transport system, permease component
D1794_RS27410	COG0644	oxidoreductase
D1794_RS27425	COG1940	carbohydrate kinase activity
D1794_RS27445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1794_RS27455	COG1349	DNA-binding transcription factor activity
D1794_RS27475	COG1215	transferase activity, transferring glycosyl groups
D1794_RS27480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1794_RS27570	COG1486	melibiose metabolic process
D1794_RS27620	COG1012	belongs to the aldehyde dehydrogenase family
D1794_RS27625	COG0363	glucosamine-6-phosphate deaminase activity
D1794_RS27650	COG1461	Dihydroxyacetone kinase
D1794_RS27655	COG2376	Dihydroxyacetone kinase
D1794_RS27690	COG1131	(ABC) transporter
D1794_RS27745	COG1846	Transcriptional regulator
D1794_RS27780	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
D1794_RS27785	COG1959	2 iron, 2 sulfur cluster binding
D1794_RS27790	COG1017	nitric oxide dioxygenase activity
D1794_RS27790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1794_RS27810	COG3511	phospholipase C
D1794_RS27820	COG1796	DNA polymerase
D1794_RS27820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D1794_RS27830	COG2814	Major facilitator Superfamily
D1794_RS27870	COG1960	acyl-CoA dehydrogenase activity
D1794_RS27880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1794_RS27895	COG1335	isochorismatase
D1794_RS27900	COG0010	Belongs to the arginase family
D1794_RS27905	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1794_RS27950	COG0701	Predicted permease
D1794_RS27960	COG0515	serine threonine protein kinase
D1794_RS27960	COG2815	serine threonine protein kinase
D1794_RS27970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1794_RS27975	COG2070	2-Nitropropane dioxygenase
D1794_RS27985	COG0387	Pfam Sodium calcium exchanger
D1794_RS27995	COG2267	carboxylic ester hydrolase activity
D1794_RS28000	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS28005	COG1024	Enoyl-CoA hydratase
D1794_RS28065	COG2375	cellular response to nickel ion
D1794_RS28065	COG1132	(ABC) transporter
D1794_RS28080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1794_RS28080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1794_RS28090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1794_RS28095	COG0765	amino acid transport
D1794_RS28100	COG1126	abc transporter atp-binding protein
D1794_RS28125	COG1957	nucleoside hydrolase
D1794_RS28135	COG2318	DinB family
D1794_RS28155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS28160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1794_RS28205	COG0501	Belongs to the peptidase M48B family
D1794_RS28250	COG4412	M6 family metalloprotease domain protein
D1794_RS28250	COG1404	Belongs to the peptidase S8 family
D1794_RS28250	COG4412	M6 family metalloprotease domain protein
D1794_RS28250	COG1404	Belongs to the peptidase S8 family
D1794_RS28305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1794_RS28325	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS28360	COG0288	reversible hydration of carbon dioxide
D1794_RS28370	COG0702	epimerase
D1794_RS28380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1794_RS28395	COG2226	methyltransferase
D1794_RS28410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1794_RS28415	COG1937	Protein conserved in bacteria
D1794_RS28445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1794_RS28505	COG0142	geranyltranstransferase activity
D1794_RS28515	COG1132	(ABC) transporter
D1794_RS28525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1794_RS28725	COG0604	alcohol dehydrogenase
D1794_RS28725	COG3321	synthase
D1794_RS28735	COG3321	synthase
D1794_RS28735	COG0604	alcohol dehydrogenase
D1794_RS28740	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1794_RS28925	COG1475	DNA binding
D1794_RS28970	COG1674	ftsk spoiiie
D1794_RS29055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1794_RS29055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1794_RS29080	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D1794_RS29320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1794_RS29360	COG0583	DNA-binding transcription factor activity
D1794_RS29365	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS29490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1794_RS29535	COG2161	toxin-antitoxin pair type II binding
D1794_RS29605	COG3547	Transposase (IS116 IS110 IS902 family)
D1794_RS29615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D1794_RS29620	COG0318	PFAM AMP-dependent synthetase and ligase
D1794_RS29695	COG2197	response regulator
D1794_RS29720	COG2814	Major facilitator Superfamily
D1794_RS29725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1794_RS29740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1794_RS29780	COG0604	alcohol dehydrogenase
D1794_RS29780	COG3321	synthase
D1794_RS29875	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1794_RS29935	COG2197	response regulator
D1794_RS29945	COG1222	aaa ATPase
D1794_RS29955	COG3903	Transcriptional regulator
D1794_RS29955	COG3629	intracellular signal transduction
D1794_RS30165	COG0577	efflux transmembrane transporter activity
D1794_RS30165	COG1136	(ABC) transporter
D1794_RS30170	COG1136	(ABC) transporter
D1794_RS30170	COG0577	efflux transmembrane transporter activity
D1794_RS30185	COG0745	RESPONSE REGULATOR receiver
D1794_RS30190	COG2205	protein histidine kinase activity
D1794_RS30215	COG4948	Mandelate Racemase Muconate Lactonizing
D1794_RS30435	COG1335	isochorismatase
D1794_RS30550	COG2201	protein-glutamate methylesterase activity
D1794_RS30565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS30570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1794_RS30575	COG0010	Belongs to the arginase family
D1794_RS30580	COG0367	asparagine synthase
D1794_RS30860	COG3959	Transketolase, thiamine diphosphate binding domain
D1794_RS30865	COG3958	Transketolase
D1794_RS30900	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D1794_RS30905	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS30910	COG0277	FAD linked oxidase domain protein
D1794_RS30915	COG1070	Carbohydrate kinase
D1794_RS30960	COG2124	cytochrome p450
D1794_RS30970	COG1011	Hydrolase
D1794_RS31005	COG0789	Transcriptional regulator
D1794_RS31015	COG3397	chitin binding
D1794_RS31045	COG1132	(ABC) transporter
D1794_RS31105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1794_RS31110	COG2124	cytochrome p450
D1794_RS31125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1794_RS31145	COG3409	Peptidoglycan-binding domain 1 protein
D1794_RS31145	COG3757	hydrolase, family 25
D1794_RS31185	COG0488	(ABC) transporter
D1794_RS31215	COG0698	ribose 5-phosphate isomerase
D1794_RS31250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1794_RS31260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1794_RS31275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1794_RS31285	COG2267	carboxylic ester hydrolase activity
D1794_RS31365	COG0477	Major facilitator Superfamily
D1794_RS31410	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS31445	COG2226	methyltransferase
D1794_RS31460	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
D1794_RS31475	COG3409	Peptidoglycan-binding domain 1 protein
D1794_RS31520	COG0494	nUDIX hydrolase
D1794_RS31540	COG3629	intracellular signal transduction
D1794_RS31540	COG3903	Transcriptional regulator
D1794_RS31570	COG1725	Transcriptional regulator
D1794_RS31575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1794_RS31585	COG1309	transcriptional regulator
D1794_RS31610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1794_RS31665	COG2318	DinB family
D1794_RS31770	COG4249	Peptidase C14 caspase catalytic subunit p20
D1794_RS31770	COG2319	Wd-40 repeat
D1794_RS31800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1794_RS31805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1794_RS31820	COG0431	NADPH-dependent FMN reductase
D1794_RS31830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS31835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS31840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1794_RS31880	COG0640	Transcriptional regulator
D1794_RS31905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1794_RS31915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1794_RS31920	COG0301	tRNA thio-modification
D1794_RS31950	COG1024	Enoyl-CoA hydratase
D1794_RS31995	COG0110	maltose O-acetyltransferase activity
D1794_RS32045	COG0477	Major facilitator Superfamily
D1794_RS32085	COG0546	phosphoglycolate phosphatase activity
D1794_RS32105	COG0363	glucosamine-6-phosphate deaminase activity
D1794_RS32110	COG1940	carbohydrate kinase activity
D1794_RS32135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1794_RS32145	COG4552	Acetyltransferase involved in intracellular survival and related
D1794_RS32155	COG2816	NAD+ diphosphatase activity
D1794_RS32165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1794_RS32170	COG1228	amidohydrolase
D1794_RS32235	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D1794_RS32240	COG1732	Glycine betaine
D1794_RS32245	COG1174	glycine betaine transport
D1794_RS32250	COG0517	IMP dehydrogenase activity
D1794_RS32250	COG1125	glycine betaine transport
D1794_RS32265	COG0076	glutamate decarboxylase activity
D1794_RS32285	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D1794_RS32290	COG1121	(ABC) transporter
D1794_RS32330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D1794_RS32475	COG1320	monovalent cation:proton antiporter activity
D1794_RS32490	COG0651	ATP synthesis coupled electron transport
D1794_RS32495	COG1006	Multisubunit Na H antiporter MnhC subunit
D1794_RS32500	COG2111	Na H antiporter
D1794_RS32500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1794_RS32545	COG0583	DNA-binding transcription factor activity
D1794_RS32560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D1794_RS32570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1794_RS32575	COG0436	Aminotransferase
D1794_RS32610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D1794_RS32625	COG2201	protein-glutamate methylesterase activity
D1794_RS32635	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS32660	COG5183	chlorophyll binding
D1794_RS32660	COG2133	pyrroloquinoline quinone binding
D1794_RS32665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1794_RS32695	COG3973	AAA domain
D1794_RS32735	COG1335	isochorismatase
D1794_RS32740	COG2319	Wd-40 repeat
D1794_RS32740	COG4249	Peptidase C14 caspase catalytic subunit p20
D1794_RS32775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1794_RS32805	COG2124	cytochrome p450
D1794_RS32915	COG1028	Short-chain dehydrogenase reductase Sdr
D1794_RS32925	COG2124	cytochrome p450
D1794_RS33000	COG0577	efflux transmembrane transporter activity
D1794_RS33000	COG1136	(ABC) transporter
D1794_RS33005	COG1136	(ABC) transporter
D1794_RS33005	COG0577	efflux transmembrane transporter activity
D1794_RS33055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1794_RS33065	COG2226	methyltransferase
D1794_RS33075	COG0640	Transcriptional regulator
D1794_RS33080	COG0346	lactoylglutathione lyase activity
D1794_RS33085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1794_RS33090	COG2124	cytochrome p450
D1794_RS33095	COG2124	cytochrome p450
D1794_RS33100	COG1695	Transcriptional regulator
D1794_RS33110	COG0436	Aminotransferase
D1794_RS33115	COG0789	Transcriptional regulator
D1794_RS33145	COG2124	cytochrome p450
D1794_RS33240	COG2197	response regulator
D1794_RS33285	COG2304	oxidoreductase activity
D1794_RS33300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1794_RS33310	COG0531	amino acid
D1794_RS33350	COG0076	glutamate decarboxylase activity
D1794_RS33370	COG2814	Major facilitator Superfamily
D1794_RS33445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1794_RS33450	COG2814	Major facilitator Superfamily
D1794_RS33475	COG2197	response regulator
D1794_RS33565	COG3547	Transposase (IS116 IS110 IS902 family)
D1794_RS33620	COG2161	toxin-antitoxin pair type II binding