locus-tag	class	description
I3J04_RS00055	COG0475	glutathione-regulated potassium exporter activity
I3J04_RS00055	COG0569	domain protein
I3J04_RS00080	COG2814	Major facilitator Superfamily
I3J04_RS00105	COG1063	alcohol dehydrogenase
I3J04_RS00110	COG0156	8-amino-7-oxononanoate synthase activity
I3J04_RS00130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J04_RS00150	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS00165	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS00170	COG0142	geranyltranstransferase activity
I3J04_RS00185	COG2124	cytochrome p450
I3J04_RS00215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J04_RS00230	COG1215	transferase activity, transferring glycosyl groups
I3J04_RS00240	COG4310	Domain of unknown function (DUF2172)
I3J04_RS00255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J04_RS00265	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS00265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J04_RS00305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J04_RS00340	COG0473	3-isopropylmalate dehydrogenase activity
I3J04_RS00385	COG1846	Transcriptional regulator
I3J04_RS00400	COG0542	response to heat
I3J04_RS00420	COG1653	transport
I3J04_RS00425	COG1233	COG1233 Phytoene dehydrogenase and related
I3J04_RS00450	COG1233	COG1233 Phytoene dehydrogenase and related
I3J04_RS00455	COG2130	NADP-dependent
I3J04_RS00460	COG2376	Dihydroxyacetone kinase
I3J04_RS00465	COG2376	Dihydroxyacetone kinase
I3J04_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS00555	COG1124	(ABC) transporter
I3J04_RS00560	COG0444	Belongs to the ABC transporter superfamily
I3J04_RS00565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS00570	COG0601	transmembrane transport
I3J04_RS00580	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS00585	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS00615	COG1125	glycine betaine transport
I3J04_RS00615	COG0517	IMP dehydrogenase activity
I3J04_RS00620	COG3458	cephalosporin-C deacetylase activity
I3J04_RS00635	COG1174	glycine betaine transport
I3J04_RS00640	COG1174	glycine betaine transport
I3J04_RS00650	COG1309	transcriptional regulator
I3J04_RS00670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J04_RS00685	COG2124	cytochrome p450
I3J04_RS00710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J04_RS00730	COG1024	Enoyl-CoA hydratase
I3J04_RS00730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J04_RS00755	COG2124	cytochrome p450
I3J04_RS00790	COG0463	Glycosyl transferase, family 2
I3J04_RS00805	COG0402	S-adenosylhomocysteine deaminase activity
I3J04_RS00825	COG1413	lyase activity
I3J04_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS00875	COG2326	polyphosphate kinase activity
I3J04_RS00880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J04_RS00930	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J04_RS00935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J04_RS00940	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J04_RS00990	COG0183	Belongs to the thiolase family
I3J04_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J04_RS01015	COG1376	ErfK ybiS ycfS ynhG family protein
I3J04_RS01035	COG0535	radical SAM domain protein
I3J04_RS01045	COG3424	synthase
I3J04_RS01055	COG3959	Transketolase, thiamine diphosphate binding domain
I3J04_RS01090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J04_RS01095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J04_RS01180	COG1131	(ABC) transporter
I3J04_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS01230	COG1309	transcriptional regulator
I3J04_RS01265	COG3903	Transcriptional regulator
I3J04_RS01265	COG3629	intracellular signal transduction
I3J04_RS01270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J04_RS01275	COG1597	lipid kinase activity
I3J04_RS01295	COG0574	Belongs to the PEP-utilizing enzyme family
I3J04_RS01295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J04_RS01335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J04_RS01340	COG0477	Major facilitator Superfamily
I3J04_RS01360	COG1174	glycine betaine transport
I3J04_RS01365	COG1174	glycine betaine transport
I3J04_RS01400	COG2957	Belongs to the agmatine deiminase family
I3J04_RS01420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J04_RS01460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J04_RS01470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J04_RS01480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS01495	COG2207	Transcriptional regulator
I3J04_RS01500	COG1120	ATPase activity
I3J04_RS01505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J04_RS01520	COG4552	Acetyltransferase involved in intracellular survival and related
I3J04_RS01540	COG2197	response regulator
I3J04_RS01545	COG0154	amidase activity
I3J04_RS01550	COG0477	Major facilitator Superfamily
I3J04_RS01555	COG0579	oxidoreductase
I3J04_RS01575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J04_RS01575	COG2755	lipolytic protein G-D-S-L family
I3J04_RS01590	COG0745	RESPONSE REGULATOR receiver
I3J04_RS01595	COG2205	protein histidine kinase activity
I3J04_RS01610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J04_RS01640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J04_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J04_RS01655	COG1609	Transcriptional regulator
I3J04_RS01660	COG0596	Alpha beta hydrolase
I3J04_RS01675	COG3572	ergothioneine biosynthetic process
I3J04_RS01680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J04_RS01685	COG0121	glutamine amidotransferase
I3J04_RS01690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J04_RS01695	COG2182	Extracellular solute-binding protein
I3J04_RS01700	COG3360	Dodecin
I3J04_RS01710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J04_RS01730	COG3300	MHYT domain
I3J04_RS01730	COG5001	Diguanylate cyclase
I3J04_RS01775	COG3275	phosphorelay sensor kinase activity
I3J04_RS01780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J04_RS01795	COG3279	Response regulator of the LytR AlgR family
I3J04_RS01810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J04_RS01865	COG0297	glycogen (starch) synthase activity
I3J04_RS01885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J04_RS01895	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J04_RS01940	COG2205	protein histidine kinase activity
I3J04_RS01945	COG0745	RESPONSE REGULATOR receiver
I3J04_RS01975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J04_RS01995	COG0248	Ppx GppA phosphatase
I3J04_RS02040	COG1175	transmembrane transport
I3J04_RS02045	COG0395	ABC-type sugar transport system, permease component
I3J04_RS02060	COG1051	belongs to the nudix hydrolase family
I3J04_RS02065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J04_RS02075	COG2318	DinB family
I3J04_RS02090	COG3251	PFAM MbtH domain protein
I3J04_RS02095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J04_RS02105	COG0667	Aldo Keto reductase
I3J04_RS02160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J04_RS02165	COG1129	ABC transporter
I3J04_RS02165	COG0842	Transport permease protein
I3J04_RS02190	COG2072	flavoprotein involved in K transport
I3J04_RS02215	COG1556	Lactate utilization protein
I3J04_RS02220	COG1139	Iron-sulfur cluster binding protein
I3J04_RS02225	COG0247	lactate metabolic process
I3J04_RS02270	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS02305	COG0500	methyltransferase
I3J04_RS02310	COG4981	capsule polysaccharide biosynthetic process
I3J04_RS02360	COG0477	Major facilitator Superfamily
I3J04_RS02380	COG2226	methyltransferase
I3J04_RS02390	COG0187	DNA topoisomerase II activity
I3J04_RS02430	COG0673	inositol 2-dehydrogenase activity
I3J04_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS02480	COG2850	peptidyl-arginine hydroxylation
I3J04_RS02540	COG3511	phospholipase C
I3J04_RS02630	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS02675	COG1116	anion transmembrane transporter activity
I3J04_RS02685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J04_RS02690	COG4948	Mandelate Racemase Muconate Lactonizing
I3J04_RS02695	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS02730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J04_RS02735	COG1309	transcriptional regulator
I3J04_RS02745	COG1196	nuclear chromosome segregation
I3J04_RS02745	COG0741	lytic transglycosylase activity
I3J04_RS02745	COG0739	heme binding
I3J04_RS02755	COG2365	Tyrosine phosphatase family
I3J04_RS02785	COG1657	PFAM Prenyltransferase squalene oxidase
I3J04_RS02795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J04_RS02805	COG1562	ergosterol biosynthetic process
I3J04_RS02810	COG1134	teichoic acid transport
I3J04_RS02825	COG0371	Dehydrogenase
I3J04_RS02850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J04_RS02865	COG1024	Enoyl-CoA hydratase
I3J04_RS02880	COG2183	response to ionizing radiation
I3J04_RS02895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J04_RS02905	COG2936	dipeptidyl-peptidase activity
I3J04_RS02925	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J04_RS02925	COG1024	Enoyl-CoA hydratase
I3J04_RS02930	COG0183	Belongs to the thiolase family
I3J04_RS02935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J04_RS02940	COG3268	Saccharopine dehydrogenase
I3J04_RS02945	COG1515	deoxyribonuclease V activity
I3J04_RS02960	COG0488	(ABC) transporter
I3J04_RS02965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J04_RS03005	COG1793	dna ligase
I3J04_RS03060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J04_RS03100	COG3012	SEC-C Motif Domain Protein
I3J04_RS03130	COG1609	Transcriptional regulator
I3J04_RS03135	COG3345	alpha-galactosidase
I3J04_RS03225	COG0475	glutathione-regulated potassium exporter activity
I3J04_RS03240	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J04_RS03245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J04_RS03250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J04_RS03340	COG1082	Xylose isomerase domain protein TIM barrel
I3J04_RS03345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J04_RS03370	COG4213	ABC transporter substrate-binding protein
I3J04_RS03375	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J04_RS03380	COG1129	ABC transporter
I3J04_RS03385	COG1940	carbohydrate kinase activity
I3J04_RS03395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J04_RS03400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J04_RS03420	COG1595	DNA-templated transcription, initiation
I3J04_RS03430	COG3250	beta-galactosidase activity
I3J04_RS03440	COG3250	beta-galactosidase activity
I3J04_RS03455	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J04_RS03460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J04_RS03470	COG0656	L-ascorbic acid biosynthetic process
I3J04_RS03480	COG1793	dna ligase
I3J04_RS03530	COG1063	alcohol dehydrogenase
I3J04_RS03600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J04_RS03605	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J04_RS03615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J04_RS03620	COG2362	D-Aminopeptidase
I3J04_RS03675	COG0604	alcohol dehydrogenase
I3J04_RS03680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS03680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS03695	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS03700	COG0688	phosphatidylethanolamine metabolic process
I3J04_RS03710	COG1929	Belongs to the glycerate kinase type-1 family
I3J04_RS03725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J04_RS03730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J04_RS03740	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J04_RS03755	COG0483	inositol monophosphate 1-phosphatase activity
I3J04_RS03760	COG0095	Lipoate-protein ligase
I3J04_RS03770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J04_RS03775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J04_RS03805	COG0405	Gamma-glutamyltransferase
I3J04_RS03815	COG0765	amino acid transport
I3J04_RS03820	COG0765	amino acid transport
I3J04_RS03825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J04_RS03830	COG1126	abc transporter atp-binding protein
I3J04_RS03850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J04_RS03860	COG1940	carbohydrate kinase activity
I3J04_RS03880	COG2188	Transcriptional regulator
I3J04_RS03885	COG0673	inositol 2-dehydrogenase activity
I3J04_RS03895	COG2197	response regulator
I3J04_RS03900	COG4585	Histidine kinase
I3J04_RS03915	COG4266	Belongs to the allantoicase family
I3J04_RS03920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J04_RS03925	COG1414	Transcriptional regulator
I3J04_RS03940	COG0746	molybdenum cofactor guanylyltransferase activity
I3J04_RS03950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J04_RS03965	COG1288	antiporter activity
I3J04_RS03995	COG2351	hydroxyisourate hydrolase activity
I3J04_RS04020	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS04025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J04_RS04030	COG2197	response regulator
I3J04_RS04045	COG3409	Peptidoglycan-binding domain 1 protein
I3J04_RS04065	COG1404	Belongs to the peptidase S8 family
I3J04_RS04080	COG0243	molybdopterin cofactor binding
I3J04_RS04115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J04_RS04130	COG2345	Transcriptional regulator
I3J04_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS04150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS04165	COG2197	response regulator
I3J04_RS04170	COG1132	(ABC) transporter
I3J04_RS04175	COG1132	(ABC) transporter
I3J04_RS04185	COG0515	serine threonine protein kinase
I3J04_RS04195	COG1609	Transcriptional regulator
I3J04_RS04240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J04_RS04255	COG3835	regulator
I3J04_RS04260	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J04_RS04270	COG3842	ATPase activity
I3J04_RS04285	COG1802	Transcriptional regulator
I3J04_RS04305	COG0028	Belongs to the TPP enzyme family
I3J04_RS04335	COG1162	GTPase activity
I3J04_RS04360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J04_RS04390	COG3290	protein histidine kinase activity
I3J04_RS04430	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS04435	COG3284	Transcriptional regulator
I3J04_RS04455	COG0175	sulfate reduction
I3J04_RS04460	COG0529	Catalyzes the synthesis of activated sulfate
I3J04_RS04480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J04_RS04485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J04_RS04520	COG1175	transmembrane transport
I3J04_RS04595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J04_RS04600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J04_RS04625	COG1764	response to oxidative stress
I3J04_RS04630	COG1846	Transcriptional regulator
I3J04_RS04650	COG3220	belongs to the UPF0276 family
I3J04_RS04665	COG0596	Alpha beta hydrolase
I3J04_RS04670	COG3253	May function as heme-dependent peroxidase
I3J04_RS04675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J04_RS04685	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J04_RS04690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J04_RS04710	COG0183	Belongs to the thiolase family
I3J04_RS04715	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J04_RS04715	COG1024	Enoyl-CoA hydratase
I3J04_RS04725	COG0531	amino acid
I3J04_RS04730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J04_RS04735	COG4214	carbohydrate transport
I3J04_RS04745	COG4213	ABC transporter substrate-binding protein
I3J04_RS04750	COG1940	carbohydrate kinase activity
I3J04_RS04755	COG0395	ABC-type sugar transport system, permease component
I3J04_RS04760	COG1175	transmembrane transport
I3J04_RS04765	COG1653	transport
I3J04_RS04775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J04_RS04780	COG1522	sequence-specific DNA binding
I3J04_RS04800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J04_RS04845	COG1024	Enoyl-CoA hydratase
I3J04_RS04850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J04_RS04860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J04_RS04880	COG2040	homocysteine
I3J04_RS04900	COG1799	cell septum assembly
I3J04_RS04920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J04_RS04940	COG4689	acetoacetate decarboxylase
I3J04_RS04970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J04_RS04985	COG0745	RESPONSE REGULATOR receiver
I3J04_RS04990	COG2205	protein histidine kinase activity
I3J04_RS05015	COG0756	dUTP diphosphatase activity
I3J04_RS05025	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J04_RS05025	COG1136	(ABC) transporter
I3J04_RS05060	COG1136	(ABC) transporter
I3J04_RS05060	COG0577	efflux transmembrane transporter activity
I3J04_RS05070	COG0569	domain protein
I3J04_RS05075	COG0531	amino acid
I3J04_RS05080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J04_RS05090	COG0483	inositol monophosphate 1-phosphatase activity
I3J04_RS05095	COG2264	protein methyltransferase activity
I3J04_RS05110	COG0494	nUDIX hydrolase
I3J04_RS05140	COG0142	geranyltranstransferase activity
I3J04_RS05215	COG2409	Drug exporters of the RND superfamily
I3J04_RS05235	COG3629	intracellular signal transduction
I3J04_RS05235	COG3903	Transcriptional regulator
I3J04_RS05245	COG2264	protein methyltransferase activity
I3J04_RS05305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J04_RS05310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS05315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J04_RS05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J04_RS05340	COG0702	epimerase
I3J04_RS05355	COG1435	thymidine kinase activity
I3J04_RS05370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J04_RS05370	COG1042	CoA-binding domain protein
I3J04_RS05370	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J04_RS05375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J04_RS05380	COG1802	Transcriptional regulator
I3J04_RS05385	COG0739	heme binding
I3J04_RS05385	COG0741	lytic transglycosylase activity
I3J04_RS05385	COG1196	nuclear chromosome segregation
I3J04_RS05395	COG0612	Peptidase, M16
I3J04_RS05400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J04_RS05410	COG0372	Belongs to the citrate synthase family
I3J04_RS05420	COG3290	protein histidine kinase activity
I3J04_RS05425	COG4565	transcriptional regulatory protein
I3J04_RS05430	COG0187	DNA topoisomerase II activity
I3J04_RS05445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J04_RS05450	COG2186	Transcriptional regulator
I3J04_RS05455	COG1131	(ABC) transporter
I3J04_RS05485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J04_RS05510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J04_RS05515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J04_RS05520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J04_RS05550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J04_RS05560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J04_RS05565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J04_RS05575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J04_RS05595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J04_RS05600	COG2358	TRAP transporter, solute receptor (TAXI family
I3J04_RS05605	COG2205	protein histidine kinase activity
I3J04_RS05610	COG0745	RESPONSE REGULATOR receiver
I3J04_RS05615	COG1126	abc transporter atp-binding protein
I3J04_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J04_RS05625	COG0765	amino acid transport
I3J04_RS05630	COG0765	amino acid transport
I3J04_RS05635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J04_RS05650	COG2137	regulation of response to DNA damage stimulus
I3J04_RS05690	COG1201	RNA secondary structure unwinding
I3J04_RS05695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J04_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS05705	COG0783	Belongs to the Dps family
I3J04_RS05710	COG1396	sequence-specific DNA binding
I3J04_RS05715	COG1546	Belongs to the CinA family
I3J04_RS05715	COG1058	Belongs to the CinA family
I3J04_RS05725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J04_RS05735	COG1674	ftsk spoiiie
I3J04_RS05745	COG0784	Response regulator, receiver
I3J04_RS05745	COG5002	protein histidine kinase activity
I3J04_RS05750	COG2208	phosphoserine phosphatase activity
I3J04_RS05750	COG2770	Histidine kinase
I3J04_RS05775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J04_RS05780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J04_RS05785	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J04_RS05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J04_RS05810	COG0612	Peptidase, M16
I3J04_RS05815	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J04_RS05820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J04_RS05830	COG1674	ftsk spoiiie
I3J04_RS05845	COG1404	Belongs to the peptidase S8 family
I3J04_RS05860	COG1404	Belongs to the peptidase S8 family
I3J04_RS05865	COG3266	domain, Protein
I3J04_RS05885	COG0455	bacterial-type flagellum organization
I3J04_RS05890	COG0747	negative chemotaxis
I3J04_RS05895	COG0601	transmembrane transport
I3J04_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS05920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J04_RS05925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J04_RS05935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J04_RS05950	COG0779	Required for maturation of 30S ribosomal subunits
I3J04_RS05970	COG0442	prolyl-tRNA aminoacylation
I3J04_RS05985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J04_RS05990	COG0750	zinc metalloprotease
I3J04_RS05995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J04_RS06010	COG2508	Transcriptional regulator
I3J04_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J04_RS06045	COG1177	transmembrane transport
I3J04_RS06050	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J04_RS06055	COG3842	ATPase activity
I3J04_RS06080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J04_RS06095	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS06105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS06110	COG1136	(ABC) transporter
I3J04_RS06125	COG3842	ATPase activity
I3J04_RS06140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J04_RS06145	COG0575	Belongs to the CDS family
I3J04_RS06150	COG0233	cytoplasmic translational termination
I3J04_RS06155	COG0528	UMP kinase activity
I3J04_RS06160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J04_RS06165	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J04_RS06180	COG1191	sigma factor activity
I3J04_RS06195	COG0792	nuclease activity
I3J04_RS06205	COG0681	Belongs to the peptidase S26 family
I3J04_RS06220	COG0681	Belongs to the peptidase S26 family
I3J04_RS06225	COG0335	large ribosomal subunit rRNA binding
I3J04_RS06230	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J04_RS06235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J04_RS06240	COG1837	Belongs to the UPF0109 family
I3J04_RS06245	COG0228	four-way junction DNA binding
I3J04_RS06255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J04_RS06265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J04_RS06295	COG4552	Acetyltransferase involved in intracellular survival and related
I3J04_RS06300	COG0477	Major facilitator Superfamily
I3J04_RS06305	COG1196	nuclear chromosome segregation
I3J04_RS06320	COG1254	Belongs to the acylphosphatase family
I3J04_RS06325	COG2340	Cysteine-rich secretory protein family
I3J04_RS06330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J04_RS06335	COG0571	ribonuclease III activity
I3J04_RS06340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J04_RS06355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J04_RS06360	COG0742	ribosomal rna small subunit methyltransferase
I3J04_RS06370	COG1461	Dihydroxyacetone kinase
I3J04_RS06375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J04_RS06380	COG0351	phosphomethylpyrimidine kinase
I3J04_RS06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J04_RS06400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J04_RS06410	COG1920	GTP binding
I3J04_RS06420	COG0776	regulation of translation
I3J04_RS06430	COG0066	3-isopropylmalate dehydratase activity
I3J04_RS06435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J04_RS06440	COG1414	Transcriptional regulator
I3J04_RS06470	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J04_RS06475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J04_RS06480	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J04_RS06490	COG5002	protein histidine kinase activity
I3J04_RS06495	COG2018	Roadblock/LC7 domain
I3J04_RS06515	COG2018	Roadblock/LC7 domain
I3J04_RS06535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J04_RS06555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J04_RS06565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J04_RS06570	COG0477	Major facilitator Superfamily
I3J04_RS06580	COG2957	Belongs to the agmatine deiminase family
I3J04_RS06585	COG0804	urea catabolic process
I3J04_RS06595	COG0831	urea catabolic process
I3J04_RS06595	COG0832	Belongs to the urease beta subunit family
I3J04_RS06620	COG0300	oxidoreductase activity
I3J04_RS06630	COG0604	alcohol dehydrogenase
I3J04_RS06630	COG3321	synthase
I3J04_RS06645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J04_RS06650	COG0473	3-isopropylmalate dehydrogenase activity
I3J04_RS06665	COG1082	Xylose isomerase domain protein TIM barrel
I3J04_RS06725	COG0640	Transcriptional regulator
I3J04_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS06735	COG0506	proline dehydrogenase activity
I3J04_RS06740	COG2508	Transcriptional regulator
I3J04_RS06740	COG2508	Transcriptional regulator
I3J04_RS06745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J04_RS06750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J04_RS06755	COG0440	acetolactate synthase activity
I3J04_RS06775	COG0667	Aldo Keto reductase
I3J04_RS06780	COG2133	pyrroloquinoline quinone binding
I3J04_RS06790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J04_RS06790	COG1672	PFAM Archaeal ATPase
I3J04_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J04_RS06810	COG2409	Drug exporters of the RND superfamily
I3J04_RS06820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J04_RS06830	COG0154	amidase activity
I3J04_RS06835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J04_RS06845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J04_RS06855	COG4221	oxidoreductase activity
I3J04_RS06860	COG1611	Belongs to the LOG family
I3J04_RS06870	COG0482	sulfurtransferase activity
I3J04_RS06895	COG2860	membrane
I3J04_RS06900	COG4608	Belongs to the ABC transporter superfamily
I3J04_RS06905	COG0444	Belongs to the ABC transporter superfamily
I3J04_RS06910	COG0601	transmembrane transport
I3J04_RS06915	COG0747	negative chemotaxis
I3J04_RS06920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS06940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J04_RS06945	COG0509	glycine decarboxylation via glycine cleavage system
I3J04_RS06950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J04_RS06955	COG1760	l-serine dehydratase
I3J04_RS06965	COG2856	Zn peptidase
I3J04_RS07095	COG1024	Enoyl-CoA hydratase
I3J04_RS07110	COG1132	(ABC) transporter
I3J04_RS07115	COG1132	(ABC) transporter
I3J04_RS07125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J04_RS07160	COG2197	response regulator
I3J04_RS07165	COG4585	Histidine kinase
I3J04_RS07175	COG0058	SHG alpha-glucan phosphorylase activity
I3J04_RS07180	COG0366	Alpha amylase catalytic
I3J04_RS07185	COG0366	Alpha amylase catalytic
I3J04_RS07195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J04_RS07210	COG1301	dicarboxylic acid transport
I3J04_RS07215	COG3290	protein histidine kinase activity
I3J04_RS07220	COG4565	transcriptional regulatory protein
I3J04_RS07225	COG0181	hydroxymethylbilane synthase activity
I3J04_RS07255	COG1175	transmembrane transport
I3J04_RS07265	COG0205	6-phosphofructokinase activity
I3J04_RS07270	COG0280	phosphate acetyltransferase
I3J04_RS07270	COG0857	belongs to the CobB CobQ family
I3J04_RS07275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J04_RS07310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS07310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS07355	COG0745	RESPONSE REGULATOR receiver
I3J04_RS07370	COG0183	Belongs to the thiolase family
I3J04_RS07390	COG1131	(ABC) transporter
I3J04_RS07425	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J04_RS07440	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J04_RS07455	COG4585	Histidine kinase
I3J04_RS07460	COG2197	response regulator
I3J04_RS07470	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J04_RS07490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J04_RS07520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J04_RS07530	COG0494	nUDIX hydrolase
I3J04_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J04_RS07550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J04_RS07555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J04_RS07560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J04_RS07565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J04_RS07570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J04_RS07575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J04_RS07595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J04_RS07600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J04_RS07610	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J04_RS07615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J04_RS07620	COG0254	rRNA binding
I3J04_RS07625	COG1316	TRANSCRIPTIONal
I3J04_RS07640	COG0083	homoserine kinase activity
I3J04_RS07645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J04_RS07650	COG0460	homoserine dehydrogenase
I3J04_RS07655	COG0019	diaminopimelate decarboxylase activity
I3J04_RS07660	COG0018	arginyl-trna synthetase
I3J04_RS07800	COG2367	Beta-lactamase
I3J04_RS07805	COG1686	Belongs to the peptidase S11 family
I3J04_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS07820	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J04_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J04_RS07845	COG2192	nodulation
I3J04_RS07855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J04_RS07865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J04_RS07875	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J04_RS07885	COG0768	penicillin binding
I3J04_RS07895	COG0367	asparagine synthase
I3J04_RS07900	COG0010	Belongs to the arginase family
I3J04_RS07905	COG2175	clavaminate synthase activity
I3J04_RS07945	COG0697	spore germination
I3J04_RS07950	COG0456	acetyltransferase
I3J04_RS07955	COG0747	negative chemotaxis
I3J04_RS07965	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J04_RS07970	COG0768	penicillin binding
I3J04_RS07975	COG0768	penicillin binding
I3J04_RS07980	COG2124	cytochrome p450
I3J04_RS07990	COG2205	protein histidine kinase activity
I3J04_RS07995	COG0745	RESPONSE REGULATOR receiver
I3J04_RS08015	COG2072	flavoprotein involved in K transport
I3J04_RS08020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J04_RS08025	COG3285	dna ligase
I3J04_RS08025	COG1793	dna ligase
I3J04_RS08030	COG1793	dna ligase
I3J04_RS08085	COG0768	penicillin binding
I3J04_RS08115	COG2318	DinB family
I3J04_RS08150	COG2205	protein histidine kinase activity
I3J04_RS08170	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J04_RS08175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J04_RS08185	COG0745	RESPONSE REGULATOR receiver
I3J04_RS08190	COG2205	protein histidine kinase activity
I3J04_RS08195	COG0567	Dehydrogenase, E1 component
I3J04_RS08195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J04_RS08205	COG2255	four-way junction helicase activity
I3J04_RS08240	COG0604	alcohol dehydrogenase
I3J04_RS08260	COG1126	abc transporter atp-binding protein
I3J04_RS08265	COG4106	trans-aconitate 2-methyltransferase activity
I3J04_RS08285	COG0494	nUDIX hydrolase
I3J04_RS08295	COG5640	endopeptidase activity
I3J04_RS08315	COG0142	geranyltranstransferase activity
I3J04_RS08350	COG1597	lipid kinase activity
I3J04_RS08365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J04_RS08370	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J04_RS08375	COG0395	ABC-type sugar transport system, permease component
I3J04_RS08380	COG1175	transmembrane transport
I3J04_RS08385	COG2182	Extracellular solute-binding protein
I3J04_RS08390	COG2188	Transcriptional regulator
I3J04_RS08415	COG0242	peptide deformylase activity
I3J04_RS08435	COG5662	AntiSigma factor
I3J04_RS08440	COG1595	DNA-templated transcription, initiation
I3J04_RS08450	COG2135	peptidase activity
I3J04_RS08460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J04_RS08470	COG2076	Multidrug Resistance protein
I3J04_RS08480	COG0483	inositol monophosphate 1-phosphatase activity
I3J04_RS08490	COG0753	catalase activity
I3J04_RS08515	COG1615	UPF0182 protein
I3J04_RS08525	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J04_RS08565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J04_RS08605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J04_RS08660	COG0601	transmembrane transport
I3J04_RS08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS08670	COG0747	negative chemotaxis
I3J04_RS08680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J04_RS08680	COG0596	Alpha beta hydrolase
I3J04_RS08710	COG0513	Belongs to the DEAD box helicase family
I3J04_RS08735	COG1432	Conserved Protein
I3J04_RS08745	COG2095	MarC family integral membrane protein
I3J04_RS08765	COG0598	Magnesium transport protein CorA
I3J04_RS08800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J04_RS08805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J04_RS08815	COG1595	DNA-templated transcription, initiation
I3J04_RS08830	COG1024	Enoyl-CoA hydratase
I3J04_RS08835	COG0519	Catalyzes the synthesis of GMP from XMP
I3J04_RS08845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J04_RS08850	COG1611	Belongs to the LOG family
I3J04_RS08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J04_RS08895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J04_RS08910	COG4608	Belongs to the ABC transporter superfamily
I3J04_RS08915	COG0444	Belongs to the ABC transporter superfamily
I3J04_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS08925	COG0601	transmembrane transport
I3J04_RS08940	COG4608	Belongs to the ABC transporter superfamily
I3J04_RS08945	COG0444	Belongs to the ABC transporter superfamily
I3J04_RS08955	COG4166	transmembrane transport
I3J04_RS08960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J04_RS08965	COG1217	gtp-binding protein TYPA
I3J04_RS08985	COG1053	succinate dehydrogenase
I3J04_RS09035	COG0012	GTP binding
I3J04_RS09050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J04_RS09055	COG0531	amino acid
I3J04_RS09060	COG1570	exodeoxyribonuclease VII activity
I3J04_RS09065	COG1722	exodeoxyribonuclease VII activity
I3J04_RS09070	COG0778	Nitroreductase
I3J04_RS09095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J04_RS09095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J04_RS09105	COG0114	fumarate hydratase activity
I3J04_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J04_RS09145	COG1136	(ABC) transporter
I3J04_RS09160	COG0450	alkyl hydroperoxide reductase
I3J04_RS09165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J04_RS09180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J04_RS09185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J04_RS09190	COG0667	Aldo Keto reductase
I3J04_RS09215	COG2885	chlorophyll binding
I3J04_RS09235	COG2197	response regulator
I3J04_RS09240	COG4585	Histidine kinase
I3J04_RS09270	COG2894	cell division
I3J04_RS09295	COG2610	gluconate transmembrane transporter activity
I3J04_RS09300	COG0251	oxidation-reduction process
I3J04_RS09305	COG1414	Transcriptional regulator
I3J04_RS09320	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J04_RS09380	COG0492	ferredoxin-NADP+ reductase activity
I3J04_RS09415	COG0728	peptidoglycan biosynthetic process
I3J04_RS09425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J04_RS09430	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS09470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J04_RS09480	COG1309	transcriptional regulator
I3J04_RS09485	COG1331	Highly conserved protein containing a thioredoxin domain
I3J04_RS09515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J04_RS09525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J04_RS09535	COG2188	Transcriptional regulator
I3J04_RS09555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J04_RS09595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J04_RS09615	COG1064	alcohol dehydrogenase
I3J04_RS09630	COG2986	histidine ammonia-lyase
I3J04_RS09640	COG1024	Enoyl-CoA hydratase
I3J04_RS09655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J04_RS09665	COG0424	maF-like protein
I3J04_RS09670	COG4770	biotin carboxylase activity
I3J04_RS09700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J04_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS09750	COG1595	DNA-templated transcription, initiation
I3J04_RS09755	COG0745	RESPONSE REGULATOR receiver
I3J04_RS09760	COG2205	protein histidine kinase activity
I3J04_RS09785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J04_RS09800	COG0583	DNA-binding transcription factor activity
I3J04_RS09805	COG2814	Major facilitator Superfamily
I3J04_RS09840	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J04_RS09845	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J04_RS09850	COG3845	ABC transporter
I3J04_RS09855	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J04_RS09860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J04_RS09860	COG1473	amidohydrolase
I3J04_RS09870	COG2089	acid synthase
I3J04_RS09875	COG1083	cytidylyl-transferase
I3J04_RS09885	COG1216	Glycosyl transferase, family 2
I3J04_RS09900	COG0517	IMP dehydrogenase activity
I3J04_RS09900	COG0516	GMP reductase activity
I3J04_RS09915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS09915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS09930	COG1595	DNA-templated transcription, initiation
I3J04_RS09940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J04_RS09945	COG2009	succinate dehydrogenase
I3J04_RS09955	COG1053	succinate dehydrogenase
I3J04_RS09960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J04_RS09970	COG1408	metallophosphoesterase
I3J04_RS09980	COG1686	Belongs to the peptidase S11 family
I3J04_RS09985	COG1295	ribonuclease BN
I3J04_RS09990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J04_RS10015	COG0180	Tryptophanyl-tRNA synthetase
I3J04_RS10020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J04_RS10025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J04_RS10030	COG0754	glutathionylspermidine amidase activity
I3J04_RS10040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J04_RS10080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J04_RS10090	COG0039	L-malate dehydrogenase activity
I3J04_RS10105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J04_RS10120	COG0138	bifunctional purine biosynthesis protein purh
I3J04_RS10150	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J04_RS10155	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J04_RS10165	COG0714	Associated with various cellular activities
I3J04_RS10180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS10180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J04_RS10190	COG0739	heme binding
I3J04_RS10210	COG2197	response regulator
I3J04_RS10235	COG0519	Catalyzes the synthesis of GMP from XMP
I3J04_RS10235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J04_RS10255	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS10275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J04_RS10285	COG0516	GMP reductase activity
I3J04_RS10295	COG1595	DNA-templated transcription, initiation
I3J04_RS10300	COG2197	response regulator
I3J04_RS10310	COG0583	DNA-binding transcription factor activity
I3J04_RS10325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J04_RS10330	COG0459	protein refolding
I3J04_RS10335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J04_RS10340	COG0726	polysaccharide deacetylase
I3J04_RS10350	COG4941	Belongs to the sigma-70 factor family
I3J04_RS10375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J04_RS10400	COG0802	atpase or kinase
I3J04_RS10410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J04_RS10430	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J04_RS10435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J04_RS10440	COG1072	(Pantothenic acid kinase))
I3J04_RS10445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J04_RS10450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J04_RS10455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J04_RS10460	COG0488	(ABC) transporter
I3J04_RS10470	COG0101	tRNA pseudouridine synthase activity
I3J04_RS10475	COG0203	ribosomal protein L17
I3J04_RS10480	COG0202	RNA polymerase activity
I3J04_RS10485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J04_RS10490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J04_RS10495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J04_RS10500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J04_RS10510	COG0563	adenylate kinase activity
I3J04_RS10520	COG0200	Binds to the 23S rRNA
I3J04_RS10525	COG1841	ribosomal large subunit assembly
I3J04_RS10530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J04_RS10535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J04_RS10540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J04_RS10545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J04_RS10550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J04_RS10555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J04_RS10560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J04_RS10565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J04_RS10570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J04_RS10575	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J04_RS10580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J04_RS10585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J04_RS10590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J04_RS10595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J04_RS10600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J04_RS10605	COG0089	rRNA binding
I3J04_RS10610	COG0088	Forms part of the polypeptide exit tunnel
I3J04_RS10615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J04_RS10620	COG0051	transcription antitermination factor activity, RNA binding
I3J04_RS10630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J04_RS10635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J04_RS10640	COG0049	tRNA binding
I3J04_RS10645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J04_RS10650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J04_RS10655	COG0085	RNA polymerase activity
I3J04_RS10660	COG0222	ribosome binding
I3J04_RS10665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J04_RS10670	COG0081	regulation of translation
I3J04_RS10675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J04_RS10685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J04_RS10695	COG0436	Aminotransferase
I3J04_RS10700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J04_RS10705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J04_RS10715	COG2030	dehydratase
I3J04_RS10720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J04_RS10740	COG0702	epimerase
I3J04_RS10760	COG1666	GTP binding
I3J04_RS10765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J04_RS10775	COG3304	Inner membrane component domain
I3J04_RS10780	COG0501	Belongs to the peptidase M48B family
I3J04_RS10785	COG1007	ATP synthesis coupled electron transport
I3J04_RS10800	COG0713	ATP synthesis coupled electron transport
I3J04_RS10805	COG0839	Belongs to the complex I subunit 6 family
I3J04_RS10810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J04_RS10820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10835	COG4585	Histidine kinase
I3J04_RS10850	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J04_RS10850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J04_RS10855	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J04_RS10880	COG1733	regulation of RNA biosynthetic process
I3J04_RS10895	COG4935	Belongs to the peptidase S8 family
I3J04_RS10895	COG2234	aminopeptidase activity
I3J04_RS10920	COG0142	geranyltranstransferase activity
I3J04_RS10925	COG2936	dipeptidyl-peptidase activity
I3J04_RS10930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J04_RS10935	COG1007	ATP synthesis coupled electron transport
I3J04_RS10945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J04_RS10950	COG0713	ATP synthesis coupled electron transport
I3J04_RS10955	COG0839	Belongs to the complex I subunit 6 family
I3J04_RS10960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J04_RS10970	COG1034	ATP synthesis coupled electron transport
I3J04_RS10975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J04_RS10985	COG0649	NAD binding
I3J04_RS10990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS10995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J04_RS11025	COG2226	methyltransferase
I3J04_RS11035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J04_RS11040	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J04_RS11045	COG1278	Cold shock
I3J04_RS11050	COG1823	symporter activity
I3J04_RS11070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J04_RS11080	COG0163	prenyltransferase activity
I3J04_RS11085	COG0109	protoheme IX farnesyltransferase activity
I3J04_RS11090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J04_RS11100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J04_RS11105	COG1333	cytochrome c biogenesis protein
I3J04_RS11110	COG0785	Cytochrome C biogenesis protein
I3J04_RS11115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J04_RS11120	COG0406	alpha-ribazole phosphatase activity
I3J04_RS11125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J04_RS11140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J04_RS11150	COG1742	UPF0060 membrane protein
I3J04_RS11165	COG0402	S-adenosylhomocysteine deaminase activity
I3J04_RS11170	COG1690	Belongs to the RtcB family
I3J04_RS11210	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J04_RS11215	COG0626	cystathionine gamma-synthase activity
I3J04_RS11230	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J04_RS11235	COG0018	arginyl-trna synthetase
I3J04_RS11255	COG0113	porphobilinogen synthase activity
I3J04_RS11360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J04_RS11365	COG0596	Alpha beta hydrolase
I3J04_RS11390	COG1136	(ABC) transporter
I3J04_RS11465	COG1725	Transcriptional regulator
I3J04_RS11485	COG1309	transcriptional regulator
I3J04_RS11505	COG0702	epimerase
I3J04_RS11515	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS11540	COG0259	pyridoxamine-phosphate oxidase activity
I3J04_RS11555	COG2072	flavoprotein involved in K transport
I3J04_RS11565	COG1024	Enoyl-CoA hydratase
I3J04_RS11575	COG0456	acetyltransferase
I3J04_RS11580	COG2814	Major facilitator Superfamily
I3J04_RS11580	COG0477	Major facilitator Superfamily
I3J04_RS11585	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J04_RS11600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J04_RS11605	COG2271	Major facilitator Superfamily
I3J04_RS11610	COG1917	Cupin 2, conserved barrel domain protein
I3J04_RS11610	COG4977	sequence-specific DNA binding
I3J04_RS11620	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS11640	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS11645	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS11655	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS11660	COG3397	chitin binding
I3J04_RS11730	COG2945	thiolester hydrolase activity
I3J04_RS11730	COG0596	Alpha beta hydrolase
I3J04_RS11740	COG4821	SIS domain
I3J04_RS11750	COG0259	pyridoxamine-phosphate oxidase activity
I3J04_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS11785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J04_RS11850	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS11895	COG0726	polysaccharide deacetylase
I3J04_RS11925	COG0577	efflux transmembrane transporter activity
I3J04_RS11930	COG0577	efflux transmembrane transporter activity
I3J04_RS11930	COG1136	(ABC) transporter
I3J04_RS11965	COG0583	DNA-binding transcription factor activity
I3J04_RS11980	COG2205	protein histidine kinase activity
I3J04_RS11985	COG0745	RESPONSE REGULATOR receiver
I3J04_RS12000	COG0277	FAD linked oxidase domain protein
I3J04_RS12000	COG0247	lactate metabolic process
I3J04_RS12010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J04_RS12050	COG0463	Glycosyl transferase, family 2
I3J04_RS12060	COG3903	Transcriptional regulator
I3J04_RS12060	COG3629	intracellular signal transduction
I3J04_RS12075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J04_RS12115	COG1122	ATPase activity
I3J04_RS12135	COG0667	Aldo Keto reductase
I3J04_RS12170	COG2252	PERMEase
I3J04_RS12180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J04_RS12200	COG2814	Major facilitator Superfamily
I3J04_RS12210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J04_RS12215	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J04_RS12220	COG1278	Cold shock
I3J04_RS12255	COG1061	Type III restriction enzyme res subunit
I3J04_RS12265	COG3973	AAA domain
I3J04_RS12280	COG1595	DNA-templated transcription, initiation
I3J04_RS12355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J04_RS12360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J04_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS12375	COG1605	Chorismate mutase
I3J04_RS12395	COG2197	response regulator
I3J04_RS12415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J04_RS12440	COG0191	fructose-bisphosphate aldolase activity
I3J04_RS12445	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J04_RS12460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J04_RS12465	COG2182	Extracellular solute-binding protein
I3J04_RS12490	COG0463	Glycosyl transferase, family 2
I3J04_RS12555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J04_RS12570	COG3842	ATPase activity
I3J04_RS12580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J04_RS12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J04_RS12595	COG0215	cysteine-tRNA ligase activity
I3J04_RS12605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J04_RS12610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J04_RS12615	COG1329	Transcriptional regulator
I3J04_RS12630	COG5002	protein histidine kinase activity
I3J04_RS12645	COG0588	phosphoglycerate mutase activity
I3J04_RS12650	COG2211	Major facilitator Superfamily
I3J04_RS12675	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS12735	COG1490	D-aminoacyl-tRNA deacylase activity
I3J04_RS12750	COG3485	protocatechuate 3,4-dioxygenase
I3J04_RS12775	COG1309	transcriptional regulator
I3J04_RS12795	COG0745	RESPONSE REGULATOR receiver
I3J04_RS12800	COG1609	Transcriptional regulator
I3J04_RS12815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J04_RS12830	COG2188	Transcriptional regulator
I3J04_RS12840	COG1525	nuclease
I3J04_RS12840	COG0737	Belongs to the 5'-nucleotidase family
I3J04_RS12840	COG4085	toxin activity
I3J04_RS12860	COG0456	acetyltransferase
I3J04_RS12865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J04_RS12875	COG0406	alpha-ribazole phosphatase activity
I3J04_RS12875	COG0494	nUDIX hydrolase
I3J04_RS12900	COG0306	phosphate transporter
I3J04_RS12910	COG1937	Protein conserved in bacteria
I3J04_RS12930	COG0671	phosphoesterase, PA-phosphatase related
I3J04_RS12935	COG1196	nuclear chromosome segregation
I3J04_RS12935	COG0741	lytic transglycosylase activity
I3J04_RS12935	COG0739	heme binding
I3J04_RS13030	COG0579	oxidoreductase
I3J04_RS13035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J04_RS13045	COG1196	nuclear chromosome segregation
I3J04_RS13045	COG0741	lytic transglycosylase activity
I3J04_RS13045	COG0739	heme binding
I3J04_RS13100	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J04_RS13110	COG0513	Belongs to the DEAD box helicase family
I3J04_RS13120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J04_RS13125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J04_RS13160	COG0785	Cytochrome C biogenesis protein
I3J04_RS13165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J04_RS13165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J04_RS13175	COG1643	Atp-dependent helicase
I3J04_RS13210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J04_RS13240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J04_RS13245	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J04_RS13250	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J04_RS13285	COG2197	response regulator
I3J04_RS13295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J04_RS13310	COG0151	Belongs to the GarS family
I3J04_RS13335	COG0017	Asparaginyl-tRNA synthetase
I3J04_RS13340	COG1051	belongs to the nudix hydrolase family
I3J04_RS13350	COG0105	UTP biosynthetic process
I3J04_RS13390	COG2826	transposase and inactivated derivatives, IS30 family
I3J04_RS13420	COG3629	intracellular signal transduction
I3J04_RS13420	COG3903	Transcriptional regulator
I3J04_RS13485	COG0477	Major facilitator Superfamily
I3J04_RS13515	COG2234	aminopeptidase activity
I3J04_RS13520	COG0433	COG0433 Predicted ATPase
I3J04_RS13535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J04_RS13580	COG1191	sigma factor activity
I3J04_RS13585	COG1191	sigma factor activity
I3J04_RS13635	COG2304	oxidoreductase activity
I3J04_RS13640	COG2205	protein histidine kinase activity
I3J04_RS13645	COG0745	RESPONSE REGULATOR receiver
I3J04_RS13650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J04_RS13670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J04_RS13695	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS13705	COG1362	aminopeptidase activity
I3J04_RS13725	COG2271	Major facilitator Superfamily
I3J04_RS13740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J04_RS13745	COG0022	dehydrogenase e1 component
I3J04_RS13770	COG0515	serine threonine protein kinase
I3J04_RS13775	COG0515	serine threonine protein kinase
I3J04_RS13790	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J04_RS13790	COG1136	(ABC) transporter
I3J04_RS13820	COG0303	'Molybdopterin
I3J04_RS13845	COG1522	sequence-specific DNA binding
I3J04_RS13850	COG1309	transcriptional regulator
I3J04_RS13855	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J04_RS13880	COG3396	Phenylacetate-CoA oxygenase
I3J04_RS13885	COG3460	Phenylacetate-CoA oxygenase
I3J04_RS13890	COG3396	Phenylacetate-CoA oxygenase
I3J04_RS13895	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J04_RS13900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J04_RS13905	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS13910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J04_RS13925	COG2197	response regulator
I3J04_RS13930	COG4585	Histidine kinase
I3J04_RS13955	COG1136	(ABC) transporter
I3J04_RS13955	COG0577	efflux transmembrane transporter activity
I3J04_RS13960	COG1136	(ABC) transporter
I3J04_RS13960	COG0577	efflux transmembrane transporter activity
I3J04_RS13970	COG1716	ATPase activity
I3J04_RS13975	COG1716	ATPase activity
I3J04_RS13990	COG0768	penicillin binding
I3J04_RS13995	COG0515	serine threonine protein kinase
I3J04_RS14000	COG3764	Sortase (surface protein transpeptidase)
I3J04_RS14005	COG3764	Sortase (surface protein transpeptidase)
I3J04_RS14020	COG3764	Sortase (surface protein transpeptidase)
I3J04_RS14035	COG0457	Tetratricopeptide repeat
I3J04_RS14035	COG0705	Rhomboid family
I3J04_RS14065	COG1446	asparaginase
I3J04_RS14070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J04_RS14075	COG1280	lysine exporter protein (LysE YggA)
I3J04_RS14080	COG1672	PFAM Archaeal ATPase
I3J04_RS14080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J04_RS14095	COG0667	Aldo Keto reductase
I3J04_RS14100	COG2175	clavaminate synthase activity
I3J04_RS14105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J04_RS14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS14115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS14130	COG0515	serine threonine protein kinase
I3J04_RS14150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J04_RS14160	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J04_RS14165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J04_RS14170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J04_RS14175	COG0592	DNA-directed DNA polymerase activity
I3J04_RS14185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J04_RS14190	COG0594	ribonuclease P activity
I3J04_RS14195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J04_RS14200	COG0706	membrane insertase activity
I3J04_RS14210	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J04_RS14215	COG1192	Involved in chromosome partitioning
I3J04_RS14230	COG3118	belongs to the thioredoxin family
I3J04_RS14235	COG0492	ferredoxin-NADP+ reductase activity
I3J04_RS14245	COG1595	DNA-templated transcription, initiation
I3J04_RS14250	COG2815	serine threonine protein kinase
I3J04_RS14250	COG0515	serine threonine protein kinase
I3J04_RS14265	COG0617	tRNA 3'-terminal CCA addition
I3J04_RS14285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J04_RS14310	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J04_RS14315	COG0629	single-stranded DNA binding
I3J04_RS14320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J04_RS14325	COG0359	binds to the 23S rRNA
I3J04_RS14335	COG0305	Participates in initiation and elongation during chromosome replication
I3J04_RS14370	COG0626	cystathionine gamma-synthase activity
I3J04_RS14375	COG1950	PFAM Membrane protein of
I3J04_RS14380	COG0662	Cupin 2, conserved barrel domain protein
I3J04_RS14400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J04_RS14415	COG1609	Transcriptional regulator
I3J04_RS14420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J04_RS14425	COG1271	oxidase subunit
I3J04_RS14430	COG1294	oxidase, subunit
I3J04_RS14435	COG4988	ABC transporter
I3J04_RS14445	COG0561	phosphatase activity
I3J04_RS14455	COG1131	(ABC) transporter
I3J04_RS14490	COG0561	phosphatase activity
I3J04_RS14495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J04_RS14500	COG0077	Prephenate dehydratase
I3J04_RS14505	COG2837	iron assimilation
I3J04_RS14520	COG1999	signal sequence binding
I3J04_RS14540	COG0006	proline dipeptidase activity
I3J04_RS14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J04_RS14600	COG0587	DNA-directed DNA polymerase activity
I3J04_RS14605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J04_RS14630	COG1595	DNA-templated transcription, initiation
I3J04_RS14635	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS14640	COG0784	Response regulator, receiver
I3J04_RS14670	COG0745	RESPONSE REGULATOR receiver
I3J04_RS14675	COG0477	Major facilitator Superfamily
I3J04_RS14695	COG0431	NADPH-dependent FMN reductase
I3J04_RS14720	COG1672	PFAM Archaeal ATPase
I3J04_RS14720	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J04_RS14725	COG0431	NADPH-dependent FMN reductase
I3J04_RS14755	COG0598	Magnesium transport protein CorA
I3J04_RS14760	COG3345	alpha-galactosidase
I3J04_RS14840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J04_RS14850	COG2226	methyltransferase
I3J04_RS14855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J04_RS14895	COG2826	transposase and inactivated derivatives, IS30 family
I3J04_RS15000	COG1857	crispr-associated protein
I3J04_RS15020	COG0436	Aminotransferase
I3J04_RS15035	COG2197	response regulator
I3J04_RS15045	COG0577	efflux transmembrane transporter activity
I3J04_RS15105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J04_RS15130	COG3903	Transcriptional regulator
I3J04_RS15130	COG3629	intracellular signal transduction
I3J04_RS15180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J04_RS15190	COG0534	Mate efflux family protein
I3J04_RS15195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J04_RS15200	COG0019	diaminopimelate decarboxylase activity
I3J04_RS15215	COG4166	transmembrane transport
I3J04_RS15220	COG0601	transmembrane transport
I3J04_RS15225	COG4171	peptide transport system, permease
I3J04_RS15240	COG2197	response regulator
I3J04_RS15245	COG4585	Histidine kinase
I3J04_RS15250	COG2409	Drug exporters of the RND superfamily
I3J04_RS15275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J04_RS15285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J04_RS15340	COG0717	Belongs to the dCTP deaminase family
I3J04_RS15355	COG2181	nitrate reductase activity
I3J04_RS15355	COG0247	lactate metabolic process
I3J04_RS15360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J04_RS15365	COG0443	Heat shock 70 kDa protein
I3J04_RS15370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J04_RS15375	COG0484	heat shock protein binding
I3J04_RS15380	COG0789	Transcriptional regulator
I3J04_RS15400	COG0542	response to heat
I3J04_RS15430	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J04_RS15445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J04_RS15450	COG0191	fructose-bisphosphate aldolase activity
I3J04_RS15455	COG0477	Major facilitator Superfamily
I3J04_RS15490	COG4585	Histidine kinase
I3J04_RS15500	COG2124	cytochrome p450
I3J04_RS15530	COG0463	Glycosyl transferase, family 2
I3J04_RS15535	COG1802	Transcriptional regulator
I3J04_RS15550	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J04_RS15550	COG2319	Wd-40 repeat
I3J04_RS15555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS15590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J04_RS15605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J04_RS15610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J04_RS15625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J04_RS15630	COG1595	DNA-templated transcription, initiation
I3J04_RS15655	COG2124	cytochrome p450
I3J04_RS15670	COG2091	lysine biosynthetic process via aminoadipic acid
I3J04_RS15685	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J04_RS15715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J04_RS15800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J04_RS15820	COG1408	metallophosphoesterase
I3J04_RS15825	COG1610	YqeY-like protein
I3J04_RS15830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J04_RS15840	COG0003	Pfam Anion-transporting ATPase
I3J04_RS15870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J04_RS15900	COG2267	carboxylic ester hydrolase activity
I3J04_RS15910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J04_RS15915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J04_RS15920	COG0659	secondary active sulfate transmembrane transporter activity
I3J04_RS15980	COG1111	helicase
I3J04_RS15980	COG1205	dead DEAH box helicase
I3J04_RS15985	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J04_RS15990	COG2172	sigma factor antagonist activity
I3J04_RS15995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J04_RS16005	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J04_RS16015	COG1754	DNA topoisomerase type I activity
I3J04_RS16015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J04_RS16020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J04_RS16025	COG0470	DNA polymerase III
I3J04_RS16035	COG0477	Major facilitator Superfamily
I3J04_RS16075	COG1061	Type III restriction enzyme res subunit
I3J04_RS16120	COG0791	NLP P60 protein
I3J04_RS16200	COG0305	Participates in initiation and elongation during chromosome replication
I3J04_RS16360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J04_RS16470	COG1132	(ABC) transporter
I3J04_RS16475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J04_RS16475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J04_RS16480	COG0110	maltose O-acetyltransferase activity
I3J04_RS16520	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS16525	COG2318	DinB family
I3J04_RS16540	COG0076	glutamate decarboxylase activity
I3J04_RS16555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J04_RS16560	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J04_RS16570	COG0037	tRNA processing
I3J04_RS16585	COG0302	gtp cyclohydrolase
I3J04_RS16600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J04_RS16625	COG1174	glycine betaine transport
I3J04_RS16640	COG0649	NAD binding
I3J04_RS16655	COG2197	response regulator
I3J04_RS16670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J04_RS16675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J04_RS16685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J04_RS16705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J04_RS16720	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J04_RS16730	COG0739	heme binding
I3J04_RS16735	COG2205	protein histidine kinase activity
I3J04_RS16740	COG0745	RESPONSE REGULATOR receiver
I3J04_RS16750	COG1595	DNA-templated transcription, initiation
I3J04_RS16755	COG1194	a g-specific adenine glycosylase
I3J04_RS16760	COG0671	phosphoesterase, PA-phosphatase related
I3J04_RS16770	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J04_RS16790	COG0248	Ppx GppA phosphatase
I3J04_RS16800	COG0129	dihydroxy-acid dehydratase activity
I3J04_RS16820	COG2226	methyltransferase
I3J04_RS16825	COG1595	DNA-templated transcription, initiation
I3J04_RS16830	COG1252	NADH dehydrogenase
I3J04_RS16835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J04_RS16840	COG0180	Tryptophanyl-tRNA synthetase
I3J04_RS16865	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J04_RS16900	COG1595	DNA-templated transcription, initiation
I3J04_RS16915	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J04_RS16920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J04_RS16925	COG0181	hydroxymethylbilane synthase activity
I3J04_RS16930	COG1648	precorrin-2 dehydrogenase activity
I3J04_RS16930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J04_RS16955	COG1846	Transcriptional regulator
I3J04_RS16960	COG3384	dioxygenase
I3J04_RS16980	COG0477	Major facilitator Superfamily
I3J04_RS16990	COG3191	aminopeptidase activity
I3J04_RS17005	COG1970	mechanosensitive ion channel activity
I3J04_RS17015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J04_RS17040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J04_RS17045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J04_RS17055	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J04_RS17060	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J04_RS17060	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J04_RS17065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J04_RS17110	COG2072	flavoprotein involved in K transport
I3J04_RS17115	COG2267	carboxylic ester hydrolase activity
I3J04_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS17125	COG0793	Belongs to the peptidase S41A family
I3J04_RS17125	COG4946	Tricorn protease homolog
I3J04_RS17135	COG2409	Drug exporters of the RND superfamily
I3J04_RS17145	COG0310	cobalt ion transport
I3J04_RS17155	COG1122	ATPase activity
I3J04_RS17160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J04_RS17200	COG0124	histidyl-tRNA synthetase
I3J04_RS17225	COG3409	Peptidoglycan-binding domain 1 protein
I3J04_RS17230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J04_RS17250	COG0442	prolyl-tRNA aminoacylation
I3J04_RS17280	COG0084	hydrolase, TatD family'
I3J04_RS17290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J04_RS17295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J04_RS17320	COG0488	(ABC) transporter
I3J04_RS17350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J04_RS17355	COG2197	response regulator
I3J04_RS17365	COG4106	trans-aconitate 2-methyltransferase activity
I3J04_RS17370	COG1309	transcriptional regulator
I3J04_RS17380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J04_RS17390	COG0193	aminoacyl-tRNA hydrolase activity
I3J04_RS17395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J04_RS17400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J04_RS17405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J04_RS17415	COG4585	Histidine kinase
I3J04_RS17445	COG0477	Major facilitator Superfamily
I3J04_RS17460	COG1136	(ABC) transporter
I3J04_RS17465	COG0577	efflux transmembrane transporter activity
I3J04_RS17475	COG1595	DNA-templated transcription, initiation
I3J04_RS17500	COG0515	serine threonine protein kinase
I3J04_RS17500	COG2815	serine threonine protein kinase
I3J04_RS17530	COG1652	LysM domain
I3J04_RS17540	COG0148	phosphopyruvate hydratase activity
I3J04_RS17560	COG1252	NADH dehydrogenase
I3J04_RS17565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J04_RS17570	COG1136	(ABC) transporter
I3J04_RS17570	COG0577	efflux transmembrane transporter activity
I3J04_RS17575	COG1136	(ABC) transporter
I3J04_RS17575	COG0577	efflux transmembrane transporter activity
I3J04_RS17605	COG0183	Belongs to the thiolase family
I3J04_RS17610	COG2755	lipolytic protein G-D-S-L family
I3J04_RS17625	COG1737	Transcriptional regulator
I3J04_RS17685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J04_RS17715	COG1228	amidohydrolase
I3J04_RS17740	COG1191	sigma factor activity
I3J04_RS17765	COG3104	oligopeptide transport
I3J04_RS17770	COG0745	RESPONSE REGULATOR receiver
I3J04_RS17775	COG2205	protein histidine kinase activity
I3J04_RS17810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J04_RS17895	COG1309	transcriptional regulator
I3J04_RS17900	COG0596	Alpha beta hydrolase
I3J04_RS17905	COG1316	TRANSCRIPTIONal
I3J04_RS17910	COG1607	acyl-coa hydrolase
I3J04_RS17915	COG1316	TRANSCRIPTIONal
I3J04_RS17935	COG1316	TRANSCRIPTIONal
I3J04_RS17960	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J04_RS17960	COG0778	Nitroreductase
I3J04_RS17965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J04_RS18000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J04_RS18005	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J04_RS18015	COG1482	cell wall glycoprotein biosynthetic process
I3J04_RS18025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J04_RS18050	COG2826	transposase and inactivated derivatives, IS30 family
I3J04_RS18060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J04_RS18065	COG0745	RESPONSE REGULATOR receiver
I3J04_RS18070	COG5002	protein histidine kinase activity
I3J04_RS18070	COG5000	phosphorelay sensor kinase activity
I3J04_RS18075	COG0823	Involved in the tonB-independent uptake of proteins
I3J04_RS18085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J04_RS18090	COG2197	response regulator
I3J04_RS18095	COG3214	Protein conserved in bacteria
I3J04_RS18105	COG0653	protein targeting
I3J04_RS18130	COG2902	Dehydrogenase
I3J04_RS18140	COG0395	ABC-type sugar transport system, permease component
I3J04_RS18145	COG1175	transmembrane transport
I3J04_RS18160	COG0515	serine threonine protein kinase
I3J04_RS18165	COG0515	serine threonine protein kinase
I3J04_RS18170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J04_RS18180	COG2884	Cell division ATP-binding protein ftsE
I3J04_RS18190	COG0793	Belongs to the peptidase S41A family
I3J04_RS18195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J04_RS18210	COG0583	DNA-binding transcription factor activity
I3J04_RS18235	COG3973	AAA domain
I3J04_RS18245	COG0776	regulation of translation
I3J04_RS18250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J04_RS18255	COG1678	Uncharacterized ACR, COG1678
I3J04_RS18270	COG1175	transmembrane transport
I3J04_RS18275	COG0395	ABC-type sugar transport system, permease component
I3J04_RS18280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J04_RS18320	COG3654	unkown
I3J04_RS18345	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J04_RS18350	COG0745	RESPONSE REGULATOR receiver
I3J04_RS18355	COG5002	protein histidine kinase activity
I3J04_RS18375	COG0277	FAD linked oxidase domain protein
I3J04_RS18415	COG1335	isochorismatase
I3J04_RS18425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J04_RS18435	COG1113	amino acid transport
I3J04_RS18445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J04_RS18450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS18455	COG1120	ATPase activity
I3J04_RS18470	COG1234	tRNA 3'-trailer cleavage
I3J04_RS18475	COG1263	PTS System
I3J04_RS18480	COG1263	PTS System
I3J04_RS18485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J04_RS18490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J04_RS18500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J04_RS18530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J04_RS18540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J04_RS18555	COG1131	(ABC) transporter
I3J04_RS18565	COG2733	membrane
I3J04_RS18595	COG0706	membrane insertase activity
I3J04_RS18605	COG0673	inositol 2-dehydrogenase activity
I3J04_RS18675	COG1126	abc transporter atp-binding protein
I3J04_RS18680	COG0765	amino acid transport
I3J04_RS18685	COG0765	amino acid transport
I3J04_RS18695	COG0154	amidase activity
I3J04_RS18705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS18740	COG0406	alpha-ribazole phosphatase activity
I3J04_RS18780	COG0745	RESPONSE REGULATOR receiver
I3J04_RS18795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J04_RS18800	COG4977	sequence-specific DNA binding
I3J04_RS18810	COG0589	response to stress
I3J04_RS18815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J04_RS18840	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J04_RS18845	COG0076	glutamate decarboxylase activity
I3J04_RS18855	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS18870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J04_RS18875	COG1309	transcriptional regulator
I3J04_RS18885	COG2124	cytochrome p450
I3J04_RS18890	COG1946	Acyl-CoA thioesterase
I3J04_RS18905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J04_RS18915	COG3960	tartronate-semialdehyde synthase activity
I3J04_RS18935	COG1674	ftsk spoiiie
I3J04_RS19000	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J04_RS19015	COG1609	Transcriptional regulator
I3J04_RS19020	COG0673	inositol 2-dehydrogenase activity
I3J04_RS19035	COG1595	DNA-templated transcription, initiation
I3J04_RS19045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J04_RS19070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J04_RS19080	COG3718	enzyme involved in inositol metabolism
I3J04_RS19085	COG3962	Belongs to the TPP enzyme family
I3J04_RS19105	COG1131	(ABC) transporter
I3J04_RS19165	COG0105	UTP biosynthetic process
I3J04_RS19170	COG2197	response regulator
I3J04_RS19180	COG2954	triphosphatase activity
I3J04_RS19190	COG0494	nUDIX hydrolase
I3J04_RS19220	COG0561	phosphatase activity
I3J04_RS19230	COG0475	glutathione-regulated potassium exporter activity
I3J04_RS19260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J04_RS19270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J04_RS19275	COG1518	maintenance of DNA repeat elements
I3J04_RS19285	COG1203	CRISPR-associated helicase, Cas3
I3J04_RS19325	COG0629	single-stranded DNA binding
I3J04_RS19355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J04_RS19400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J04_RS19415	COG1486	melibiose metabolic process
I3J04_RS19420	COG0395	ABC-type sugar transport system, permease component
I3J04_RS19425	COG1175	transmembrane transport
I3J04_RS19445	COG0668	transmembrane transport
I3J04_RS19515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J04_RS19520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J04_RS19530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J04_RS19540	COG0588	phosphoglycerate mutase activity
I3J04_RS19545	COG1113	amino acid transport
I3J04_RS19555	COG1113	amino acid transport
I3J04_RS19570	COG4552	Acetyltransferase involved in intracellular survival and related
I3J04_RS19585	COG0475	glutathione-regulated potassium exporter activity
I3J04_RS19600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J04_RS19605	COG3594	Acyltransferase
I3J04_RS19625	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J04_RS19630	COG0740	serine-type endopeptidase activity
I3J04_RS19635	COG0740	serine-type endopeptidase activity
I3J04_RS19640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J04_RS19650	COG0525	valine-tRNA ligase activity
I3J04_RS19655	COG4585	Histidine kinase
I3J04_RS19660	COG0285	dihydrofolate synthase activity
I3J04_RS19670	COG0105	UTP biosynthetic process
I3J04_RS19675	COG1077	Cell shape determining protein MreB Mrl
I3J04_RS19695	COG0772	Belongs to the SEDS family
I3J04_RS19715	COG1530	ribonuclease E activity
I3J04_RS19725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J04_RS19730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J04_RS19735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J04_RS19740	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS19755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J04_RS19765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J04_RS19780	COG0501	Belongs to the peptidase M48B family
I3J04_RS19790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J04_RS19800	COG0799	negative regulation of ribosome biogenesis
I3J04_RS19805	COG0588	phosphoglycerate mutase activity
I3J04_RS19815	COG0495	leucyl-tRNA aminoacylation
I3J04_RS19825	COG1307	EDD domain protein, DegV family
I3J04_RS19860	COG0268	Binds directly to 16S ribosomal RNA
I3J04_RS19865	COG0481	GTPase activity
I3J04_RS19890	COG1420	regulation of RNA biosynthetic process
I3J04_RS19895	COG0484	heat shock protein binding
I3J04_RS19915	COG4946	Tricorn protease homolog
I3J04_RS19915	COG0793	Belongs to the peptidase S41A family
I3J04_RS19920	COG0537	adenosine 5'-monophosphoramidase activity
I3J04_RS19925	COG1234	tRNA 3'-trailer cleavage
I3J04_RS19930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J04_RS19935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J04_RS19945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J04_RS19985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J04_RS20000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J04_RS20015	COG1381	Involved in DNA repair and RecF pathway recombination
I3J04_RS20020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J04_RS20030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J04_RS20035	COG3842	ATPase activity
I3J04_RS20040	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J04_RS20040	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J04_RS20045	COG0423	glycine-tRNA ligase activity
I3J04_RS20085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J04_RS20085	COG0574	Belongs to the PEP-utilizing enzyme family
I3J04_RS20100	COG0531	amino acid
I3J04_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS20115	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J04_RS20135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J04_RS20155	COG2949	membrane
I3J04_RS20160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J04_RS20170	COG0358	DNA primase activity
I3J04_RS20175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J04_RS20190	COG1070	Carbohydrate kinase
I3J04_RS20225	COG1129	ABC transporter
I3J04_RS20225	COG0842	Transport permease protein
I3J04_RS20285	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS20295	COG1136	(ABC) transporter
I3J04_RS20350	COG2130	NADP-dependent
I3J04_RS20385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J04_RS20390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J04_RS20395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J04_RS20420	COG0789	Transcriptional regulator
I3J04_RS20425	COG0667	Aldo Keto reductase
I3J04_RS20430	COG2197	response regulator
I3J04_RS20435	COG4585	Histidine kinase
I3J04_RS20455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J04_RS20460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J04_RS20505	COG1358	cellular component organization or biogenesis
I3J04_RS20515	COG0586	Pfam SNARE associated Golgi protein
I3J04_RS20540	COG0582	viral genome integration into host DNA
I3J04_RS20650	COG4122	O-methyltransferase activity
I3J04_RS20660	COG2124	cytochrome p450
I3J04_RS20665	COG0183	Belongs to the thiolase family
I3J04_RS20680	COG3845	ABC transporter
I3J04_RS20715	COG1309	transcriptional regulator
I3J04_RS20720	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS20725	COG2226	methyltransferase
I3J04_RS20735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS20755	COG0183	Belongs to the thiolase family
I3J04_RS20770	COG2030	dehydratase
I3J04_RS20775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J04_RS20780	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS20795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J04_RS20815	COG0800	Aldolase
I3J04_RS20820	COG3022	response to hydroperoxide
I3J04_RS20835	COG0789	Transcriptional regulator
I3J04_RS20855	COG1349	DNA-binding transcription factor activity
I3J04_RS20860	COG1653	transport
I3J04_RS20870	COG0395	ABC-type sugar transport system, permease component
I3J04_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS20920	COG3540	Alkaline phosphatase
I3J04_RS20925	COG2814	Major facilitator Superfamily
I3J04_RS20940	COG1834	amidinotransferase
I3J04_RS20960	COG1120	ATPase activity
I3J04_RS20965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS20990	COG5398	heme oxygenase
I3J04_RS21025	COG1994	Peptidase M50
I3J04_RS21045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J04_RS21055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J04_RS21055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J04_RS21060	COG2132	Multicopper oxidase
I3J04_RS21095	COG0174	glutamine synthetase
I3J04_RS21110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J04_RS21125	COG1228	amidohydrolase
I3J04_RS21150	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J04_RS21155	COG0494	nUDIX hydrolase
I3J04_RS21170	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J04_RS21190	COG1609	Transcriptional regulator
I3J04_RS21195	COG0366	Alpha amylase catalytic
I3J04_RS21200	COG3833	ABC-type maltose transport systems, permease component
I3J04_RS21205	COG1175	transmembrane transport
I3J04_RS21235	COG2197	response regulator
I3J04_RS21275	COG0745	RESPONSE REGULATOR receiver
I3J04_RS21285	COG0673	inositol 2-dehydrogenase activity
I3J04_RS21310	COG0181	hydroxymethylbilane synthase activity
I3J04_RS21360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J04_RS21365	COG0321	lipoyl(octanoyl) transferase activity
I3J04_RS21380	COG1090	epimerase
I3J04_RS21410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J04_RS21420	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J04_RS21425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J04_RS21430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J04_RS21435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J04_RS21445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J04_RS21475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J04_RS21480	COG1132	(ABC) transporter
I3J04_RS21505	COG4585	Histidine kinase
I3J04_RS21510	COG2197	response regulator
I3J04_RS21515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J04_RS21525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J04_RS21545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J04_RS21555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J04_RS21560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J04_RS21570	COG1376	ErfK ybiS ycfS ynhG family protein
I3J04_RS21580	COG1845	cytochrome c oxidase, subunit III
I3J04_RS21585	COG2010	Cytochrome c
I3J04_RS21590	COG0723	plastoquinol--plastocyanin reductase activity
I3J04_RS21595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J04_RS21600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J04_RS21605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J04_RS21610	COG1929	Belongs to the glycerate kinase type-1 family
I3J04_RS21620	COG0745	RESPONSE REGULATOR receiver
I3J04_RS21625	COG2205	protein histidine kinase activity
I3J04_RS21675	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS21700	COG0003	Pfam Anion-transporting ATPase
I3J04_RS21710	COG1940	carbohydrate kinase activity
I3J04_RS21740	COG2197	response regulator
I3J04_RS21745	COG0205	6-phosphofructokinase activity
I3J04_RS21755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J04_RS21760	COG0243	molybdopterin cofactor binding
I3J04_RS21765	COG2193	ferroxidase activity
I3J04_RS21770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J04_RS21775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J04_RS21780	COG0515	serine threonine protein kinase
I3J04_RS21780	COG2815	serine threonine protein kinase
I3J04_RS21785	COG2022	thiamine diphosphate biosynthetic process
I3J04_RS21795	COG2022	thiamine diphosphate biosynthetic process
I3J04_RS21795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J04_RS21815	COG0352	thiamine-phosphate diphosphorylase activity
I3J04_RS21830	COG1233	COG1233 Phytoene dehydrogenase and related
I3J04_RS21840	COG1309	transcriptional regulator
I3J04_RS21845	COG1511	domain protein
I3J04_RS21850	COG1121	(ABC) transporter
I3J04_RS21880	COG0714	Associated with various cellular activities
I3J04_RS21890	COG0275	rRNA processing
I3J04_RS21900	COG0768	penicillin binding
I3J04_RS21905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J04_RS21910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J04_RS21915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J04_RS21920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J04_RS21930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J04_RS21935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J04_RS21945	COG1496	oxidoreductase activity
I3J04_RS21955	COG1799	cell septum assembly
I3J04_RS21965	COG3599	regulation of cell shape
I3J04_RS21970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J04_RS21985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J04_RS22035	COG0587	DNA-directed DNA polymerase activity
I3J04_RS22045	COG1432	Conserved Protein
I3J04_RS22065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J04_RS22085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J04_RS22090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J04_RS22095	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J04_RS22105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J04_RS22110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J04_RS22115	COG0251	oxidation-reduction process
I3J04_RS22120	COG0107	imidazoleglycerol-phosphate synthase activity
I3J04_RS22135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J04_RS22140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J04_RS22160	COG0134	indole-3-glycerol-phosphate synthase activity
I3J04_RS22170	COG0133	tryptophan synthase activity
I3J04_RS22175	COG0159	tryptophan synthase activity
I3J04_RS22185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J04_RS22190	COG2301	Belongs to the HpcH HpaI aldolase family
I3J04_RS22195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J04_RS22200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J04_RS22235	COG0067	glutamate synthase
I3J04_RS22235	COG0070	glutamate synthase
I3J04_RS22235	COG0069	glutamate synthase activity
I3J04_RS22260	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS22270	COG1309	transcriptional regulator
I3J04_RS22275	COG0183	Belongs to the thiolase family
I3J04_RS22305	COG1024	Enoyl-CoA hydratase
I3J04_RS22315	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS22330	COG1470	cell adhesion involved in biofilm formation
I3J04_RS22330	COG0366	Alpha amylase catalytic
I3J04_RS22345	COG0287	Prephenate dehydrogenase
I3J04_RS22345	COG1605	Chorismate mutase
I3J04_RS22395	COG0411	ABC transporter
I3J04_RS22415	COG2050	protein possibly involved in aromatic compounds catabolism
I3J04_RS22445	COG1643	Atp-dependent helicase
I3J04_RS22450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J04_RS22450	COG0596	Alpha beta hydrolase
I3J04_RS22450	COG2226	methyltransferase
I3J04_RS22455	COG0539	negative regulation of cytoplasmic translation
I3J04_RS22465	COG0237	dephospho-CoA kinase activity
I3J04_RS22485	COG0330	HflC and HflK could
I3J04_RS22490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J04_RS22520	COG2313	pseudouridylate synthase activity
I3J04_RS22530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J04_RS22535	COG0584	glycerophosphoryl diester phosphodiesterase
I3J04_RS22545	COG0556	nucleotide-excision repair
I3J04_RS22565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J04_RS22575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J04_RS22580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J04_RS22580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J04_RS22605	COG0322	excinuclease ABC activity
I3J04_RS22610	COG1660	Displays ATPase and GTPase activities
I3J04_RS22615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J04_RS22620	COG1481	regulation of sporulation
I3J04_RS22630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J04_RS22635	COG0126	phosphoglycerate kinase activity
I3J04_RS22640	COG0149	triose-phosphate isomerase activity
I3J04_RS22645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J04_RS22655	COG0166	Belongs to the GPI family
I3J04_RS22660	COG3402	PFAM membrane-flanked domain
I3J04_RS22670	COG0363	glucosamine-6-phosphate deaminase activity
I3J04_RS22685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J04_RS22695	COG0109	protoheme IX farnesyltransferase activity
I3J04_RS22725	COG1131	(ABC) transporter
I3J04_RS22740	COG0719	Fe-S assembly protein
I3J04_RS22750	COG0396	ATPase activity
I3J04_RS22755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J04_RS22760	COG0822	iron-sulfur transferase activity
I3J04_RS22765	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J04_RS22770	COG2171	N-acyltransferase activity
I3J04_RS22780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J04_RS22830	COG2205	protein histidine kinase activity
I3J04_RS22835	COG0745	RESPONSE REGULATOR receiver
I3J04_RS22850	COG1802	Transcriptional regulator
I3J04_RS22865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J04_RS22870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J04_RS22880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J04_RS22890	COG0768	penicillin binding
I3J04_RS22895	COG2197	response regulator
I3J04_RS22900	COG4585	Histidine kinase
I3J04_RS22905	COG1414	Transcriptional regulator
I3J04_RS22930	COG1902	pentaerythritol trinitrate reductase activity
I3J04_RS22935	COG5285	phytanoyl-CoA dioxygenase
I3J04_RS22940	COG1917	Cupin 2, conserved barrel domain protein
I3J04_RS22955	COG0134	indole-3-glycerol-phosphate synthase activity
I3J04_RS22985	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J04_RS23000	COG1492	cobalamin metabolic process
I3J04_RS23005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J04_RS23020	COG0235	Class ii aldolase
I3J04_RS23035	COG0488	(ABC) transporter
I3J04_RS23045	COG1024	Enoyl-CoA hydratase
I3J04_RS23085	COG3387	PFAM Glycoside hydrolase 15-related
I3J04_RS23120	COG1404	Belongs to the peptidase S8 family
I3J04_RS23130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J04_RS23135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J04_RS23155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J04_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS23175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J04_RS23180	COG2186	Transcriptional regulator
I3J04_RS23185	COG2807	transmembrane transport
I3J04_RS23200	COG0560	Phosphoserine phosphatase
I3J04_RS23200	COG3830	Belongs to the UPF0237 family
I3J04_RS23205	COG1131	(ABC) transporter
I3J04_RS23205	COG0842	Transport permease protein
I3J04_RS23205	COG1716	ATPase activity
I3J04_RS23215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J04_RS23225	COG4585	Histidine kinase
I3J04_RS23230	COG2197	response regulator
I3J04_RS23245	COG1119	ATPase activity
I3J04_RS23270	COG1881	PFAM PEBP family protein
I3J04_RS23280	COG2094	Belongs to the DNA glycosylase MPG family
I3J04_RS23315	COG0647	UMP catabolic process
I3J04_RS23320	COG1120	ATPase activity
I3J04_RS23340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J04_RS23345	COG0497	DNA recombination
I3J04_RS23350	COG0297	glycogen (starch) synthase activity
I3J04_RS23360	COG3387	PFAM Glycoside hydrolase 15-related
I3J04_RS23365	COG0504	CTP synthase activity
I3J04_RS23370	COG0494	nUDIX hydrolase
I3J04_RS23380	COG0686	Belongs to the AlaDH PNT family
I3J04_RS23395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J04_RS23400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J04_RS23405	COG1187	pseudouridine synthase activity
I3J04_RS23410	COG1056	cytidyltransferase-related domain
I3J04_RS23410	COG1051	belongs to the nudix hydrolase family
I3J04_RS23435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J04_RS23445	COG1160	GTP binding
I3J04_RS23465	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS23475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J04_RS23485	COG0671	phosphoesterase, PA-phosphatase related
I3J04_RS23490	COG0477	Major facilitator Superfamily
I3J04_RS23495	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS23500	COG1799	cell septum assembly
I3J04_RS23550	COG0641	radical SAM
I3J04_RS23565	COG3903	Transcriptional regulator
I3J04_RS23565	COG3629	intracellular signal transduction
I3J04_RS23570	COG0596	Alpha beta hydrolase
I3J04_RS23595	COG4565	transcriptional regulatory protein
I3J04_RS23620	COG1725	Transcriptional regulator
I3J04_RS23630	COG2755	lipolytic protein G-D-S-L family
I3J04_RS23640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J04_RS23645	COG2188	Transcriptional regulator
I3J04_RS23650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J04_RS23655	COG2851	Citrate transporter
I3J04_RS23690	COG3876	Protein conserved in bacteria
I3J04_RS23705	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS23720	COG2149	membrane
I3J04_RS23740	COG3265	gluconokinase activity
I3J04_RS23745	COG2186	Transcriptional regulator
I3J04_RS23750	COG1113	amino acid transport
I3J04_RS23780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J04_RS23810	COG0667	Aldo Keto reductase
I3J04_RS23815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS23825	COG0598	Magnesium transport protein CorA
I3J04_RS23845	COG0215	cysteine-tRNA ligase activity
I3J04_RS23855	COG4948	Mandelate Racemase Muconate Lactonizing
I3J04_RS23860	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS23870	COG1129	ABC transporter
I3J04_RS23880	COG2186	Transcriptional regulator
I3J04_RS23885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J04_RS23890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J04_RS23895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J04_RS23900	COG1414	Transcriptional regulator
I3J04_RS23905	COG1410	methionine synthase
I3J04_RS23905	COG0646	methionine synthase
I3J04_RS23910	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS23925	COG2197	response regulator
I3J04_RS23935	COG1994	Peptidase M50
I3J04_RS23935	COG0517	IMP dehydrogenase activity
I3J04_RS23955	COG1222	aaa ATPase
I3J04_RS23960	COG4122	O-methyltransferase activity
I3J04_RS23975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J04_RS23980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J04_RS23985	COG1609	Transcriptional regulator
I3J04_RS23995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J04_RS24030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J04_RS24035	COG0805	protein transport
I3J04_RS24070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J04_RS24075	COG0517	IMP dehydrogenase activity
I3J04_RS24075	COG4175	Glycine betaine
I3J04_RS24095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J04_RS24100	COG1113	amino acid transport
I3J04_RS24105	COG2186	Transcriptional regulator
I3J04_RS24110	COG0174	glutamine synthetase
I3J04_RS24135	COG1404	Belongs to the peptidase S8 family
I3J04_RS24155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J04_RS24160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J04_RS24165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J04_RS24170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J04_RS24175	COG5002	protein histidine kinase activity
I3J04_RS24180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J04_RS24185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J04_RS24185	COG0072	phenylalanine-tRNA ligase activity
I3J04_RS24205	COG1649	PFAM Uncharacterised BCR, COG1649
I3J04_RS24215	COG0697	spore germination
I3J04_RS24225	COG2838	Isocitrate dehydrogenase
I3J04_RS24250	COG4585	Histidine kinase
I3J04_RS24255	COG2197	response regulator
I3J04_RS24260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J04_RS24265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J04_RS24270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J04_RS24275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J04_RS24280	COG1438	arginine binding
I3J04_RS24285	COG0137	argininosuccinate synthase activity
I3J04_RS24290	COG0165	Argininosuccinate lyase
I3J04_RS24300	COG0477	Major facilitator Superfamily
I3J04_RS24305	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS24305	COG0204	Acyl-transferase
I3J04_RS24310	COG0584	glycerophosphoryl diester phosphodiesterase
I3J04_RS24330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J04_RS24335	COG2011	ABC-type metal ion transport system permease component
I3J04_RS24340	COG1464	Belongs to the NlpA lipoprotein family
I3J04_RS24355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J04_RS24360	COG1648	precorrin-2 dehydrogenase activity
I3J04_RS24360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J04_RS24405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J04_RS24415	COG0456	acetyltransferase
I3J04_RS24465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J04_RS24470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J04_RS24475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J04_RS24495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J04_RS24500	COG1560	Kdo2-lipid A biosynthetic process
I3J04_RS24505	COG0438	transferase activity, transferring glycosyl groups
I3J04_RS24515	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J04_RS24520	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J04_RS24525	COG0217	transcriptional regulatory protein
I3J04_RS24530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J04_RS24535	COG0632	four-way junction helicase activity
I3J04_RS24540	COG2255	four-way junction helicase activity
I3J04_RS24550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J04_RS24555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J04_RS24560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J04_RS24565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J04_RS24575	COG1196	nuclear chromosome segregation
I3J04_RS24580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J04_RS24590	COG0124	histidyl-tRNA synthetase
I3J04_RS24610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J04_RS24625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J04_RS24630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J04_RS24635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J04_RS24640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J04_RS24645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J04_RS24650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J04_RS24655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J04_RS24660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J04_RS24670	COG0006	proline dipeptidase activity
I3J04_RS24675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J04_RS24680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J04_RS24690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J04_RS24695	COG0540	Belongs to the ATCase OTCase family
I3J04_RS24700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J04_RS24710	COG0505	Belongs to the CarA family
I3J04_RS24715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J04_RS24720	COG0167	dihydroorotate dehydrogenase activity
I3J04_RS24725	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J04_RS24750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J04_RS24765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J04_RS24775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J04_RS24780	COG2390	Transcriptional regulator
I3J04_RS24810	COG1191	sigma factor activity
I3J04_RS24820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J04_RS24835	COG2233	PERMEase
I3J04_RS24845	COG0738	Major facilitator superfamily
I3J04_RS24850	COG1940	carbohydrate kinase activity
I3J04_RS24850	COG1846	Transcriptional regulator
I3J04_RS24865	COG3201	nicotinamide mononucleotide transporter
I3J04_RS24870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J04_RS24870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J04_RS24875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J04_RS24880	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J04_RS24885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J04_RS24925	COG1309	transcriptional regulator
I3J04_RS24930	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS24950	COG1216	Glycosyl transferase, family 2
I3J04_RS24965	COG2270	Major facilitator Superfamily
I3J04_RS24975	COG2364	Membrane
I3J04_RS24980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J04_RS25010	COG1984	allophanate hydrolase subunit 2
I3J04_RS25015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J04_RS25020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J04_RS25025	COG2814	Major facilitator Superfamily
I3J04_RS25055	COG5002	protein histidine kinase activity
I3J04_RS25060	COG2018	Roadblock/LC7 domain
I3J04_RS25075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J04_RS25080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J04_RS25085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J04_RS25105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J04_RS25115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J04_RS25145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J04_RS25165	COG1716	ATPase activity
I3J04_RS25185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J04_RS25195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J04_RS25195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J04_RS25260	COG0697	spore germination
I3J04_RS25315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J04_RS25330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J04_RS25340	COG2813	Specifically methylates the guanine in position
I3J04_RS25355	COG1968	undecaprenyl-diphosphatase activity
I3J04_RS25370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J04_RS25395	COG2124	cytochrome p450
I3J04_RS25425	COG0110	maltose O-acetyltransferase activity
I3J04_RS25430	COG1832	CoA-binding protein
I3J04_RS25435	COG1739	Uncharacterized protein family UPF0029
I3J04_RS25445	COG0666	response to abiotic stimulus
I3J04_RS25450	COG0420	3'-5' exonuclease activity
I3J04_RS25455	COG0419	ATPase involved in DNA repair
I3J04_RS25455	COG0419	ATPase involved in DNA repair
I3J04_RS25460	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS25490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J04_RS25505	COG2188	Transcriptional regulator
I3J04_RS25510	COG1940	carbohydrate kinase activity
I3J04_RS25520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J04_RS25555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J04_RS25560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS25565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J04_RS25585	COG0740	serine-type endopeptidase activity
I3J04_RS25595	COG0831	urea catabolic process
I3J04_RS25600	COG0832	Belongs to the urease beta subunit family
I3J04_RS25605	COG0804	urea catabolic process
I3J04_RS25615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J04_RS25620	COG0829	nickel cation binding
I3J04_RS25630	COG0204	Acyl-transferase
I3J04_RS25645	COG0142	geranyltranstransferase activity
I3J04_RS25650	COG0142	geranyltranstransferase activity
I3J04_RS25670	COG0205	6-phosphofructokinase activity
I3J04_RS25675	COG3442	glutamine amidotransferase
I3J04_RS25685	COG0242	peptide deformylase activity
I3J04_RS25695	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS25720	COG0386	Belongs to the glutathione peroxidase family
I3J04_RS25725	COG1946	Acyl-CoA thioesterase
I3J04_RS25745	COG2375	cellular response to nickel ion
I3J04_RS25745	COG1132	(ABC) transporter
I3J04_RS25750	COG1132	(ABC) transporter
I3J04_RS25760	COG2409	Drug exporters of the RND superfamily
I3J04_RS25775	COG2124	cytochrome p450
I3J04_RS25785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J04_RS25795	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS25810	COG0477	Major facilitator Superfamily
I3J04_RS25840	COG4585	Histidine kinase
I3J04_RS25845	COG2197	response regulator
I3J04_RS25865	COG2409	Drug exporters of the RND superfamily
I3J04_RS25875	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J04_RS25875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J04_RS25880	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J04_RS25935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J04_RS25940	COG3321	synthase
I3J04_RS25940	COG0604	alcohol dehydrogenase
I3J04_RS25955	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS25975	COG1132	(ABC) transporter
I3J04_RS25980	COG2072	flavoprotein involved in K transport
I3J04_RS26040	COG0443	Heat shock 70 kDa protein
I3J04_RS26055	COG1309	transcriptional regulator
I3J04_RS26065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS26070	COG1902	pentaerythritol trinitrate reductase activity
I3J04_RS26125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J04_RS26170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS26175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS26180	COG1120	ATPase activity
I3J04_RS26190	COG1132	(ABC) transporter
I3J04_RS26215	COG4607	ABC-type enterochelin transport system periplasmic component
I3J04_RS26220	COG0464	growth
I3J04_RS26225	COG1404	Belongs to the peptidase S8 family
I3J04_RS26230	COG1674	ftsk spoiiie
I3J04_RS26295	COG1278	Cold shock
I3J04_RS26310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J04_RS26320	COG0577	efflux transmembrane transporter activity
I3J04_RS26320	COG1136	(ABC) transporter
I3J04_RS26325	COG1136	(ABC) transporter
I3J04_RS26325	COG0577	efflux transmembrane transporter activity
I3J04_RS26340	COG0745	RESPONSE REGULATOR receiver
I3J04_RS26345	COG2205	protein histidine kinase activity
I3J04_RS26380	COG0463	Glycosyl transferase, family 2
I3J04_RS26385	COG0326	Molecular chaperone. Has ATPase activity
I3J04_RS26425	COG0309	Hydrogenase expression formation protein (HypE)
I3J04_RS26435	COG0298	carbon dioxide binding
I3J04_RS26445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J04_RS26450	COG0375	protein maturation
I3J04_RS26530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J04_RS26565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J04_RS26580	COG2706	6-phosphogluconolactonase activity
I3J04_RS26595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J04_RS26620	COG1309	transcriptional regulator
I3J04_RS26625	COG0671	phosphoesterase, PA-phosphatase related
I3J04_RS26650	COG0584	glycerophosphoryl diester phosphodiesterase
I3J04_RS26670	COG0204	Acyl-transferase
I3J04_RS26680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J04_RS26700	COG3345	alpha-galactosidase
I3J04_RS26710	COG1175	transmembrane transport
I3J04_RS26715	COG0395	ABC-type sugar transport system, permease component
I3J04_RS26735	COG0644	oxidoreductase
I3J04_RS26750	COG1940	carbohydrate kinase activity
I3J04_RS26770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J04_RS26780	COG1349	DNA-binding transcription factor activity
I3J04_RS26800	COG1215	transferase activity, transferring glycosyl groups
I3J04_RS26805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J04_RS26890	COG1486	melibiose metabolic process
I3J04_RS26935	COG1012	belongs to the aldehyde dehydrogenase family
I3J04_RS26940	COG0363	glucosamine-6-phosphate deaminase activity
I3J04_RS26965	COG1461	Dihydroxyacetone kinase
I3J04_RS26970	COG2376	Dihydroxyacetone kinase
I3J04_RS27005	COG1131	(ABC) transporter
I3J04_RS27060	COG1846	Transcriptional regulator
I3J04_RS27095	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J04_RS27100	COG1959	2 iron, 2 sulfur cluster binding
I3J04_RS27105	COG1017	nitric oxide dioxygenase activity
I3J04_RS27105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J04_RS27125	COG3511	phospholipase C
I3J04_RS27135	COG1796	DNA polymerase
I3J04_RS27135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J04_RS27145	COG2814	Major facilitator Superfamily
I3J04_RS27185	COG1960	acyl-CoA dehydrogenase activity
I3J04_RS27195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J04_RS27210	COG1335	isochorismatase
I3J04_RS27215	COG0010	Belongs to the arginase family
I3J04_RS27220	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J04_RS27265	COG0701	Predicted permease
I3J04_RS27275	COG0515	serine threonine protein kinase
I3J04_RS27275	COG2815	serine threonine protein kinase
I3J04_RS27285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J04_RS27290	COG2070	2-Nitropropane dioxygenase
I3J04_RS27300	COG0387	Pfam Sodium calcium exchanger
I3J04_RS27305	COG2267	carboxylic ester hydrolase activity
I3J04_RS27310	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS27375	COG2375	cellular response to nickel ion
I3J04_RS27375	COG1132	(ABC) transporter
I3J04_RS27390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J04_RS27390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J04_RS27400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J04_RS27405	COG0765	amino acid transport
I3J04_RS27410	COG1126	abc transporter atp-binding protein
I3J04_RS27430	COG1957	nucleoside hydrolase
I3J04_RS27440	COG2318	DinB family
I3J04_RS27460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS27465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J04_RS27510	COG0501	Belongs to the peptidase M48B family
I3J04_RS27550	COG4412	M6 family metalloprotease domain protein
I3J04_RS27550	COG1404	Belongs to the peptidase S8 family
I3J04_RS27550	COG4412	M6 family metalloprotease domain protein
I3J04_RS27550	COG1404	Belongs to the peptidase S8 family
I3J04_RS27605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J04_RS27620	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS27655	COG0288	reversible hydration of carbon dioxide
I3J04_RS27665	COG0702	epimerase
I3J04_RS27675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J04_RS27690	COG2226	methyltransferase
I3J04_RS27700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J04_RS27705	COG1937	Protein conserved in bacteria
I3J04_RS27735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J04_RS27800	COG0142	geranyltranstransferase activity
I3J04_RS27810	COG1132	(ABC) transporter
I3J04_RS27820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J04_RS28040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J04_RS28205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J04_RS28250	COG2161	toxin-antitoxin pair type II binding
I3J04_RS28295	COG3547	Transposase (IS116 IS110 IS902 family)
I3J04_RS28305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J04_RS28310	COG0318	PFAM AMP-dependent synthetase and ligase
I3J04_RS28380	COG2197	response regulator
I3J04_RS28410	COG2814	Major facilitator Superfamily
I3J04_RS28415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J04_RS28430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J04_RS28470	COG0604	alcohol dehydrogenase
I3J04_RS28470	COG3321	synthase
I3J04_RS28490	COG2814	Major facilitator Superfamily
I3J04_RS28510	COG0076	glutamate decarboxylase activity
I3J04_RS28545	COG0531	amino acid
I3J04_RS28555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J04_RS28570	COG2304	oxidoreductase activity
I3J04_RS28610	COG2197	response regulator
I3J04_RS28620	COG1222	aaa ATPase
I3J04_RS28630	COG3903	Transcriptional regulator
I3J04_RS28630	COG3629	intracellular signal transduction
I3J04_RS28705	COG2124	cytochrome p450
I3J04_RS28735	COG0789	Transcriptional regulator
I3J04_RS28740	COG0436	Aminotransferase
I3J04_RS28750	COG1695	Transcriptional regulator
I3J04_RS28755	COG2124	cytochrome p450
I3J04_RS28760	COG2124	cytochrome p450
I3J04_RS28765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J04_RS28770	COG0346	lactoylglutathione lyase activity
I3J04_RS28775	COG0640	Transcriptional regulator
I3J04_RS28785	COG2226	methyltransferase
I3J04_RS28795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J04_RS28845	COG0577	efflux transmembrane transporter activity
I3J04_RS28845	COG1136	(ABC) transporter
I3J04_RS28850	COG0577	efflux transmembrane transporter activity
I3J04_RS28850	COG1136	(ABC) transporter
I3J04_RS28865	COG0745	RESPONSE REGULATOR receiver
I3J04_RS28870	COG2205	protein histidine kinase activity
I3J04_RS28900	COG4948	Mandelate Racemase Muconate Lactonizing
I3J04_RS28935	COG2124	cytochrome p450
I3J04_RS28945	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS29055	COG2124	cytochrome p450
I3J04_RS29080	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J04_RS29115	COG2319	Wd-40 repeat
I3J04_RS29115	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J04_RS29120	COG1335	isochorismatase
I3J04_RS29160	COG3409	Peptidoglycan-binding domain 1 protein
I3J04_RS29165	COG3973	AAA domain
I3J04_RS29195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J04_RS29200	COG5183	chlorophyll binding
I3J04_RS29200	COG2133	pyrroloquinoline quinone binding
I3J04_RS29225	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS29235	COG2201	protein-glutamate methylesterase activity
I3J04_RS29250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS29255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J04_RS29260	COG0010	Belongs to the arginase family
I3J04_RS29265	COG0367	asparagine synthase
I3J04_RS29285	COG0436	Aminotransferase
I3J04_RS29290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J04_RS29300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J04_RS29315	COG0583	DNA-binding transcription factor activity
I3J04_RS29360	COG2111	Na H antiporter
I3J04_RS29360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J04_RS29365	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J04_RS29370	COG0651	ATP synthesis coupled electron transport
I3J04_RS29385	COG1320	monovalent cation:proton antiporter activity
I3J04_RS29530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J04_RS29575	COG1121	(ABC) transporter
I3J04_RS29580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J04_RS29600	COG0076	glutamate decarboxylase activity
I3J04_RS29615	COG0517	IMP dehydrogenase activity
I3J04_RS29615	COG1125	glycine betaine transport
I3J04_RS29620	COG1174	glycine betaine transport
I3J04_RS29625	COG1732	Glycine betaine
I3J04_RS29630	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J04_RS29685	COG1228	amidohydrolase
I3J04_RS29690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J04_RS29700	COG2816	NAD+ diphosphatase activity
I3J04_RS29710	COG4552	Acetyltransferase involved in intracellular survival and related
I3J04_RS29720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J04_RS29745	COG1940	carbohydrate kinase activity
I3J04_RS29750	COG0363	glucosamine-6-phosphate deaminase activity
I3J04_RS29765	COG0546	phosphoglycolate phosphatase activity
I3J04_RS29805	COG0477	Major facilitator Superfamily
I3J04_RS29845	COG0110	maltose O-acetyltransferase activity
I3J04_RS29890	COG1024	Enoyl-CoA hydratase
I3J04_RS29920	COG0301	tRNA thio-modification
I3J04_RS29925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J04_RS29935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J04_RS29955	COG0640	Transcriptional regulator
I3J04_RS29990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS29995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS30000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J04_RS30010	COG0431	NADPH-dependent FMN reductase
I3J04_RS30025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J04_RS30030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J04_RS30060	COG2319	Wd-40 repeat
I3J04_RS30060	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J04_RS30155	COG2318	DinB family
I3J04_RS30205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J04_RS30230	COG1309	transcriptional regulator
I3J04_RS30240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3J04_RS30245	COG1725	Transcriptional regulator
I3J04_RS30270	COG3629	intracellular signal transduction
I3J04_RS30270	COG3903	Transcriptional regulator
I3J04_RS30285	COG0494	nUDIX hydrolase
I3J04_RS30325	COG3409	Peptidoglycan-binding domain 1 protein
I3J04_RS30340	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J04_RS30355	COG2226	methyltransferase
I3J04_RS30390	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS30435	COG0477	Major facilitator Superfamily
I3J04_RS30515	COG2267	carboxylic ester hydrolase activity
I3J04_RS30525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J04_RS30540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J04_RS30550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J04_RS30585	COG0698	ribose 5-phosphate isomerase
I3J04_RS30615	COG0488	(ABC) transporter
I3J04_RS30650	COG3757	hydrolase, family 25
I3J04_RS30650	COG3409	Peptidoglycan-binding domain 1 protein
I3J04_RS30670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J04_RS30685	COG2124	cytochrome p450
I3J04_RS30690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J04_RS30750	COG1132	(ABC) transporter
I3J04_RS30780	COG3397	chitin binding
I3J04_RS30790	COG0789	Transcriptional regulator
I3J04_RS30830	COG1011	Hydrolase
I3J04_RS30840	COG2124	cytochrome p450
I3J04_RS30885	COG1070	Carbohydrate kinase
I3J04_RS30890	COG0277	FAD linked oxidase domain protein
I3J04_RS30895	COG1028	Short-chain dehydrogenase reductase Sdr
I3J04_RS30900	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J04_RS30935	COG3958	Transketolase
I3J04_RS30940	COG3959	Transketolase, thiamine diphosphate binding domain