locus-tag	class	description
I3J07_RS00045	COG1966	Carbon starvation protein
I3J07_RS00095	COG0475	glutathione-regulated potassium exporter activity
I3J07_RS00095	COG0569	domain protein
I3J07_RS00120	COG2814	Major facilitator Superfamily
I3J07_RS00145	COG1063	alcohol dehydrogenase
I3J07_RS00150	COG0156	8-amino-7-oxononanoate synthase activity
I3J07_RS00160	COG2018	Roadblock/LC7 domain
I3J07_RS00175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J07_RS00195	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS00210	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS00215	COG0142	geranyltranstransferase activity
I3J07_RS00230	COG2124	cytochrome p450
I3J07_RS00260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J07_RS00275	COG1215	transferase activity, transferring glycosyl groups
I3J07_RS00285	COG4310	Domain of unknown function (DUF2172)
I3J07_RS00300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J07_RS00310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J07_RS00310	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS00345	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS00350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J07_RS00385	COG0473	3-isopropylmalate dehydrogenase activity
I3J07_RS00435	COG1846	Transcriptional regulator
I3J07_RS00450	COG0542	response to heat
I3J07_RS00455	COG2172	sigma factor antagonist activity
I3J07_RS00455	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J07_RS00455	COG2208	phosphoserine phosphatase activity
I3J07_RS00470	COG1653	transport
I3J07_RS00500	COG1233	COG1233 Phytoene dehydrogenase and related
I3J07_RS00505	COG2130	NADP-dependent
I3J07_RS00510	COG2376	Dihydroxyacetone kinase
I3J07_RS00515	COG2376	Dihydroxyacetone kinase
I3J07_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS00570	COG2124	cytochrome p450
I3J07_RS00610	COG1124	(ABC) transporter
I3J07_RS00615	COG0444	Belongs to the ABC transporter superfamily
I3J07_RS00620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS00625	COG0601	transmembrane transport
I3J07_RS00635	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS00640	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS00670	COG1125	glycine betaine transport
I3J07_RS00670	COG0517	IMP dehydrogenase activity
I3J07_RS00675	COG3458	cephalosporin-C deacetylase activity
I3J07_RS00690	COG1174	glycine betaine transport
I3J07_RS00705	COG1309	transcriptional regulator
I3J07_RS00725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J07_RS00740	COG2124	cytochrome p450
I3J07_RS00765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J07_RS00785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J07_RS00785	COG1024	Enoyl-CoA hydratase
I3J07_RS00810	COG2124	cytochrome p450
I3J07_RS00845	COG0463	Glycosyl transferase, family 2
I3J07_RS00860	COG0402	S-adenosylhomocysteine deaminase activity
I3J07_RS00900	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS00930	COG2326	polyphosphate kinase activity
I3J07_RS00985	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J07_RS00990	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J07_RS00995	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J07_RS01045	COG0183	Belongs to the thiolase family
I3J07_RS01065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J07_RS01070	COG1376	ErfK ybiS ycfS ynhG family protein
I3J07_RS01090	COG0535	radical SAM domain protein
I3J07_RS01100	COG3424	synthase
I3J07_RS01110	COG3959	Transketolase, thiamine diphosphate binding domain
I3J07_RS01145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J07_RS01150	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J07_RS01235	COG1131	(ABC) transporter
I3J07_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS01285	COG1309	transcriptional regulator
I3J07_RS01320	COG3629	intracellular signal transduction
I3J07_RS01320	COG3903	Transcriptional regulator
I3J07_RS01325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J07_RS01330	COG1597	lipid kinase activity
I3J07_RS01350	COG0574	Belongs to the PEP-utilizing enzyme family
I3J07_RS01350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J07_RS01390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J07_RS01395	COG0477	Major facilitator Superfamily
I3J07_RS01415	COG1174	glycine betaine transport
I3J07_RS01420	COG1174	glycine betaine transport
I3J07_RS01455	COG2957	Belongs to the agmatine deiminase family
I3J07_RS01475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J07_RS01515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J07_RS01525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J07_RS01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS01550	COG2207	Transcriptional regulator
I3J07_RS01555	COG1120	ATPase activity
I3J07_RS01560	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J07_RS01575	COG4552	Acetyltransferase involved in intracellular survival and related
I3J07_RS01595	COG2197	response regulator
I3J07_RS01600	COG0154	amidase activity
I3J07_RS01605	COG0477	Major facilitator Superfamily
I3J07_RS01610	COG0579	oxidoreductase
I3J07_RS01630	COG2755	lipolytic protein G-D-S-L family
I3J07_RS01630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J07_RS01645	COG0745	RESPONSE REGULATOR receiver
I3J07_RS01650	COG2205	protein histidine kinase activity
I3J07_RS01665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J07_RS01695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J07_RS01700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J07_RS01710	COG1609	Transcriptional regulator
I3J07_RS01715	COG0596	Alpha beta hydrolase
I3J07_RS01730	COG3572	ergothioneine biosynthetic process
I3J07_RS01735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J07_RS01740	COG0121	glutamine amidotransferase
I3J07_RS01745	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J07_RS01750	COG2182	Extracellular solute-binding protein
I3J07_RS01755	COG3360	Dodecin
I3J07_RS01765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J07_RS01785	COG5001	Diguanylate cyclase
I3J07_RS01785	COG3300	MHYT domain
I3J07_RS01830	COG3275	phosphorelay sensor kinase activity
I3J07_RS01835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J07_RS01850	COG3279	Response regulator of the LytR AlgR family
I3J07_RS01865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J07_RS01920	COG0297	glycogen (starch) synthase activity
I3J07_RS01940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J07_RS01950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J07_RS01995	COG2205	protein histidine kinase activity
I3J07_RS02000	COG0745	RESPONSE REGULATOR receiver
I3J07_RS02030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J07_RS02050	COG0248	Ppx GppA phosphatase
I3J07_RS02095	COG1175	transmembrane transport
I3J07_RS02100	COG0395	ABC-type sugar transport system, permease component
I3J07_RS02115	COG1051	belongs to the nudix hydrolase family
I3J07_RS02120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J07_RS02130	COG2318	DinB family
I3J07_RS02145	COG3251	PFAM MbtH domain protein
I3J07_RS02150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J07_RS02160	COG0667	Aldo Keto reductase
I3J07_RS02215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J07_RS02245	COG2072	flavoprotein involved in K transport
I3J07_RS02270	COG1556	Lactate utilization protein
I3J07_RS02275	COG1139	Iron-sulfur cluster binding protein
I3J07_RS02280	COG0247	lactate metabolic process
I3J07_RS02325	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS02360	COG0500	methyltransferase
I3J07_RS02415	COG0477	Major facilitator Superfamily
I3J07_RS02435	COG2226	methyltransferase
I3J07_RS02445	COG0187	DNA topoisomerase II activity
I3J07_RS02485	COG0673	inositol 2-dehydrogenase activity
I3J07_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS02535	COG2850	peptidyl-arginine hydroxylation
I3J07_RS02595	COG3511	phospholipase C
I3J07_RS02685	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS02730	COG1116	anion transmembrane transporter activity
I3J07_RS02740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J07_RS02745	COG4948	Mandelate Racemase Muconate Lactonizing
I3J07_RS02750	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS02785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J07_RS02790	COG1309	transcriptional regulator
I3J07_RS02800	COG1196	nuclear chromosome segregation
I3J07_RS02800	COG0741	lytic transglycosylase activity
I3J07_RS02800	COG0739	heme binding
I3J07_RS02810	COG2365	Tyrosine phosphatase family
I3J07_RS02840	COG1657	PFAM Prenyltransferase squalene oxidase
I3J07_RS02850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J07_RS02860	COG1562	ergosterol biosynthetic process
I3J07_RS02865	COG1134	teichoic acid transport
I3J07_RS02880	COG0371	Dehydrogenase
I3J07_RS02905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J07_RS02935	COG2183	response to ionizing radiation
I3J07_RS02950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J07_RS02960	COG2936	dipeptidyl-peptidase activity
I3J07_RS02980	COG1024	Enoyl-CoA hydratase
I3J07_RS02980	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J07_RS02985	COG0183	Belongs to the thiolase family
I3J07_RS02990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J07_RS02995	COG3268	Saccharopine dehydrogenase
I3J07_RS03000	COG1515	deoxyribonuclease V activity
I3J07_RS03015	COG0488	(ABC) transporter
I3J07_RS03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J07_RS03060	COG1793	dna ligase
I3J07_RS03115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J07_RS03155	COG3012	SEC-C Motif Domain Protein
I3J07_RS03185	COG1609	Transcriptional regulator
I3J07_RS03190	COG3345	alpha-galactosidase
I3J07_RS03280	COG0475	glutathione-regulated potassium exporter activity
I3J07_RS03295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J07_RS03300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J07_RS03305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J07_RS03395	COG1082	Xylose isomerase domain protein TIM barrel
I3J07_RS03400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J07_RS03420	COG0673	inositol 2-dehydrogenase activity
I3J07_RS03425	COG4213	ABC transporter substrate-binding protein
I3J07_RS03430	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J07_RS03435	COG1129	ABC transporter
I3J07_RS03440	COG1940	carbohydrate kinase activity
I3J07_RS03450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J07_RS03455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J07_RS03475	COG1595	DNA-templated transcription, initiation
I3J07_RS03485	COG3250	beta-galactosidase activity
I3J07_RS03495	COG3250	beta-galactosidase activity
I3J07_RS03510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J07_RS03515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J07_RS03525	COG0656	L-ascorbic acid biosynthetic process
I3J07_RS03535	COG1793	dna ligase
I3J07_RS03585	COG1063	alcohol dehydrogenase
I3J07_RS03655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J07_RS03660	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J07_RS03670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J07_RS03675	COG2362	D-Aminopeptidase
I3J07_RS03730	COG0604	alcohol dehydrogenase
I3J07_RS03735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS03735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS03750	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS03755	COG0688	phosphatidylethanolamine metabolic process
I3J07_RS03765	COG1929	Belongs to the glycerate kinase type-1 family
I3J07_RS03780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J07_RS03785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J07_RS03795	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J07_RS03810	COG0483	inositol monophosphate 1-phosphatase activity
I3J07_RS03815	COG0095	Lipoate-protein ligase
I3J07_RS03825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J07_RS03830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J07_RS03860	COG0405	Gamma-glutamyltransferase
I3J07_RS03870	COG0765	amino acid transport
I3J07_RS03875	COG0765	amino acid transport
I3J07_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J07_RS03885	COG1126	abc transporter atp-binding protein
I3J07_RS03905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J07_RS03915	COG1940	carbohydrate kinase activity
I3J07_RS03935	COG2188	Transcriptional regulator
I3J07_RS03940	COG0673	inositol 2-dehydrogenase activity
I3J07_RS03950	COG2197	response regulator
I3J07_RS03955	COG4585	Histidine kinase
I3J07_RS03970	COG4266	Belongs to the allantoicase family
I3J07_RS03975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J07_RS03980	COG1414	Transcriptional regulator
I3J07_RS03995	COG0746	molybdenum cofactor guanylyltransferase activity
I3J07_RS04005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J07_RS04020	COG1288	antiporter activity
I3J07_RS04050	COG2351	hydroxyisourate hydrolase activity
I3J07_RS04075	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS04080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J07_RS04085	COG2197	response regulator
I3J07_RS04100	COG3409	Peptidoglycan-binding domain 1 protein
I3J07_RS04120	COG1404	Belongs to the peptidase S8 family
I3J07_RS04135	COG0243	molybdopterin cofactor binding
I3J07_RS04170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J07_RS04185	COG2345	Transcriptional regulator
I3J07_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS04205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS04220	COG2197	response regulator
I3J07_RS04225	COG1132	(ABC) transporter
I3J07_RS04230	COG1132	(ABC) transporter
I3J07_RS04240	COG0515	serine threonine protein kinase
I3J07_RS04250	COG1609	Transcriptional regulator
I3J07_RS04295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J07_RS04310	COG3835	regulator
I3J07_RS04315	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J07_RS04325	COG3842	ATPase activity
I3J07_RS04340	COG1802	Transcriptional regulator
I3J07_RS04360	COG0028	Belongs to the TPP enzyme family
I3J07_RS04390	COG1162	GTPase activity
I3J07_RS04415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J07_RS04445	COG3290	protein histidine kinase activity
I3J07_RS04485	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS04490	COG3284	Transcriptional regulator
I3J07_RS04510	COG0175	sulfate reduction
I3J07_RS04515	COG0529	Catalyzes the synthesis of activated sulfate
I3J07_RS04535	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J07_RS04540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J07_RS04575	COG1175	transmembrane transport
I3J07_RS04650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J07_RS04655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J07_RS04680	COG1764	response to oxidative stress
I3J07_RS04685	COG1846	Transcriptional regulator
I3J07_RS04705	COG3220	belongs to the UPF0276 family
I3J07_RS04720	COG0596	Alpha beta hydrolase
I3J07_RS04725	COG3253	May function as heme-dependent peroxidase
I3J07_RS04730	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J07_RS04740	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J07_RS04745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J07_RS04765	COG0183	Belongs to the thiolase family
I3J07_RS04770	COG1024	Enoyl-CoA hydratase
I3J07_RS04770	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J07_RS04780	COG0531	amino acid
I3J07_RS04785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J07_RS04790	COG4214	carbohydrate transport
I3J07_RS04800	COG4213	ABC transporter substrate-binding protein
I3J07_RS04805	COG1940	carbohydrate kinase activity
I3J07_RS04810	COG0395	ABC-type sugar transport system, permease component
I3J07_RS04815	COG1175	transmembrane transport
I3J07_RS04820	COG1653	transport
I3J07_RS04830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J07_RS04835	COG1522	sequence-specific DNA binding
I3J07_RS04855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J07_RS04900	COG1024	Enoyl-CoA hydratase
I3J07_RS04905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J07_RS04915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J07_RS04935	COG2040	homocysteine
I3J07_RS04955	COG1799	cell septum assembly
I3J07_RS04975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J07_RS04995	COG4689	acetoacetate decarboxylase
I3J07_RS05025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J07_RS05040	COG0745	RESPONSE REGULATOR receiver
I3J07_RS05045	COG2205	protein histidine kinase activity
I3J07_RS05070	COG0756	dUTP diphosphatase activity
I3J07_RS05080	COG1136	(ABC) transporter
I3J07_RS05080	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J07_RS05115	COG1136	(ABC) transporter
I3J07_RS05115	COG0577	efflux transmembrane transporter activity
I3J07_RS05125	COG0569	domain protein
I3J07_RS05130	COG0531	amino acid
I3J07_RS05135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J07_RS05145	COG0483	inositol monophosphate 1-phosphatase activity
I3J07_RS05150	COG2264	protein methyltransferase activity
I3J07_RS05165	COG0494	nUDIX hydrolase
I3J07_RS05195	COG0142	geranyltranstransferase activity
I3J07_RS05250	COG2409	Drug exporters of the RND superfamily
I3J07_RS05270	COG3629	intracellular signal transduction
I3J07_RS05270	COG3903	Transcriptional regulator
I3J07_RS05280	COG2264	protein methyltransferase activity
I3J07_RS05340	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J07_RS05345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS05350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J07_RS05365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J07_RS05375	COG0702	epimerase
I3J07_RS05390	COG1435	thymidine kinase activity
I3J07_RS05405	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J07_RS05405	COG1042	CoA-binding domain protein
I3J07_RS05405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J07_RS05410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J07_RS05415	COG1802	Transcriptional regulator
I3J07_RS05420	COG1196	nuclear chromosome segregation
I3J07_RS05420	COG0741	lytic transglycosylase activity
I3J07_RS05420	COG0739	heme binding
I3J07_RS05430	COG0612	Peptidase, M16
I3J07_RS05435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J07_RS05445	COG0372	Belongs to the citrate synthase family
I3J07_RS05455	COG3290	protein histidine kinase activity
I3J07_RS05460	COG4565	transcriptional regulatory protein
I3J07_RS05465	COG0187	DNA topoisomerase II activity
I3J07_RS05480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J07_RS05485	COG2186	Transcriptional regulator
I3J07_RS05490	COG1131	(ABC) transporter
I3J07_RS05520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J07_RS05545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J07_RS05550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J07_RS05555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J07_RS05585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J07_RS05595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J07_RS05600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J07_RS05610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J07_RS05630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J07_RS05635	COG2358	TRAP transporter, solute receptor (TAXI family
I3J07_RS05640	COG2205	protein histidine kinase activity
I3J07_RS05645	COG0745	RESPONSE REGULATOR receiver
I3J07_RS05650	COG1126	abc transporter atp-binding protein
I3J07_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J07_RS05660	COG0765	amino acid transport
I3J07_RS05665	COG0765	amino acid transport
I3J07_RS05670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J07_RS05685	COG2137	regulation of response to DNA damage stimulus
I3J07_RS05725	COG1201	RNA secondary structure unwinding
I3J07_RS05730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J07_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS05740	COG0783	Belongs to the Dps family
I3J07_RS05745	COG1396	sequence-specific DNA binding
I3J07_RS05750	COG1058	Belongs to the CinA family
I3J07_RS05750	COG1546	Belongs to the CinA family
I3J07_RS05760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J07_RS05770	COG1674	ftsk spoiiie
I3J07_RS05780	COG5002	protein histidine kinase activity
I3J07_RS05780	COG0784	Response regulator, receiver
I3J07_RS05785	COG2770	Histidine kinase
I3J07_RS05785	COG2208	phosphoserine phosphatase activity
I3J07_RS05810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J07_RS05815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J07_RS05820	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J07_RS05840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J07_RS05845	COG0612	Peptidase, M16
I3J07_RS05850	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J07_RS05855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J07_RS05865	COG1674	ftsk spoiiie
I3J07_RS05880	COG1404	Belongs to the peptidase S8 family
I3J07_RS05895	COG1404	Belongs to the peptidase S8 family
I3J07_RS05900	COG3266	domain, Protein
I3J07_RS05920	COG0455	bacterial-type flagellum organization
I3J07_RS05925	COG0747	negative chemotaxis
I3J07_RS05930	COG0601	transmembrane transport
I3J07_RS05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS05955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J07_RS05960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J07_RS05970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J07_RS05985	COG0779	Required for maturation of 30S ribosomal subunits
I3J07_RS06005	COG0442	prolyl-tRNA aminoacylation
I3J07_RS06020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J07_RS06025	COG0750	zinc metalloprotease
I3J07_RS06030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J07_RS06045	COG2508	Transcriptional regulator
I3J07_RS06075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J07_RS06080	COG1177	transmembrane transport
I3J07_RS06085	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J07_RS06090	COG3842	ATPase activity
I3J07_RS06115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J07_RS06130	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS06140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS06145	COG1136	(ABC) transporter
I3J07_RS06160	COG3842	ATPase activity
I3J07_RS06175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J07_RS06180	COG0575	Belongs to the CDS family
I3J07_RS06185	COG0233	cytoplasmic translational termination
I3J07_RS06190	COG0528	UMP kinase activity
I3J07_RS06195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J07_RS06200	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J07_RS06215	COG1191	sigma factor activity
I3J07_RS06230	COG0792	nuclease activity
I3J07_RS06240	COG0681	Belongs to the peptidase S26 family
I3J07_RS06255	COG0681	Belongs to the peptidase S26 family
I3J07_RS06260	COG0335	large ribosomal subunit rRNA binding
I3J07_RS06265	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J07_RS06270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J07_RS06275	COG1837	Belongs to the UPF0109 family
I3J07_RS06280	COG0228	four-way junction DNA binding
I3J07_RS06290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J07_RS06300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J07_RS06330	COG4552	Acetyltransferase involved in intracellular survival and related
I3J07_RS06335	COG0477	Major facilitator Superfamily
I3J07_RS06340	COG1196	nuclear chromosome segregation
I3J07_RS06355	COG1254	Belongs to the acylphosphatase family
I3J07_RS06360	COG2340	Cysteine-rich secretory protein family
I3J07_RS06365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J07_RS06370	COG0571	ribonuclease III activity
I3J07_RS06375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J07_RS06390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J07_RS06395	COG0742	ribosomal rna small subunit methyltransferase
I3J07_RS06405	COG1461	Dihydroxyacetone kinase
I3J07_RS06410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J07_RS06415	COG0351	phosphomethylpyrimidine kinase
I3J07_RS06430	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J07_RS06435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J07_RS06445	COG1920	GTP binding
I3J07_RS06455	COG0776	regulation of translation
I3J07_RS06465	COG0066	3-isopropylmalate dehydratase activity
I3J07_RS06470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J07_RS06475	COG1414	Transcriptional regulator
I3J07_RS06505	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J07_RS06510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J07_RS06515	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J07_RS06525	COG5002	protein histidine kinase activity
I3J07_RS06530	COG2018	Roadblock/LC7 domain
I3J07_RS06550	COG2018	Roadblock/LC7 domain
I3J07_RS06570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J07_RS06590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J07_RS06600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J07_RS06605	COG0477	Major facilitator Superfamily
I3J07_RS06615	COG2957	Belongs to the agmatine deiminase family
I3J07_RS06620	COG0804	urea catabolic process
I3J07_RS06630	COG0831	urea catabolic process
I3J07_RS06630	COG0832	Belongs to the urease beta subunit family
I3J07_RS06655	COG0300	oxidoreductase activity
I3J07_RS06665	COG3321	synthase
I3J07_RS06665	COG0604	alcohol dehydrogenase
I3J07_RS06680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J07_RS06685	COG0473	3-isopropylmalate dehydrogenase activity
I3J07_RS06700	COG1082	Xylose isomerase domain protein TIM barrel
I3J07_RS06760	COG0640	Transcriptional regulator
I3J07_RS06765	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS06770	COG0506	proline dehydrogenase activity
I3J07_RS06775	COG2508	Transcriptional regulator
I3J07_RS06775	COG2508	Transcriptional regulator
I3J07_RS06780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J07_RS06785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J07_RS06790	COG0440	acetolactate synthase activity
I3J07_RS06810	COG0667	Aldo Keto reductase
I3J07_RS06815	COG2133	pyrroloquinoline quinone binding
I3J07_RS06825	COG1672	PFAM Archaeal ATPase
I3J07_RS06825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J07_RS06840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J07_RS06845	COG2409	Drug exporters of the RND superfamily
I3J07_RS06855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J07_RS06865	COG0154	amidase activity
I3J07_RS06870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J07_RS06880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J07_RS06890	COG4221	oxidoreductase activity
I3J07_RS06895	COG1611	Belongs to the LOG family
I3J07_RS06905	COG0482	sulfurtransferase activity
I3J07_RS06930	COG2860	membrane
I3J07_RS06935	COG4608	Belongs to the ABC transporter superfamily
I3J07_RS06940	COG0444	Belongs to the ABC transporter superfamily
I3J07_RS06945	COG0601	transmembrane transport
I3J07_RS06950	COG0747	negative chemotaxis
I3J07_RS06955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS06975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J07_RS06980	COG0509	glycine decarboxylation via glycine cleavage system
I3J07_RS06985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J07_RS06990	COG1760	l-serine dehydratase
I3J07_RS07000	COG2856	Zn peptidase
I3J07_RS07130	COG1024	Enoyl-CoA hydratase
I3J07_RS07145	COG1132	(ABC) transporter
I3J07_RS07150	COG1132	(ABC) transporter
I3J07_RS07160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J07_RS07195	COG2197	response regulator
I3J07_RS07200	COG4585	Histidine kinase
I3J07_RS07210	COG0058	SHG alpha-glucan phosphorylase activity
I3J07_RS07215	COG0366	Alpha amylase catalytic
I3J07_RS07220	COG0366	Alpha amylase catalytic
I3J07_RS07230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J07_RS07245	COG1301	dicarboxylic acid transport
I3J07_RS07250	COG3290	protein histidine kinase activity
I3J07_RS07255	COG4565	transcriptional regulatory protein
I3J07_RS07260	COG0181	hydroxymethylbilane synthase activity
I3J07_RS07290	COG1175	transmembrane transport
I3J07_RS07300	COG0205	6-phosphofructokinase activity
I3J07_RS07305	COG0857	belongs to the CobB CobQ family
I3J07_RS07305	COG0280	phosphate acetyltransferase
I3J07_RS07310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J07_RS07345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS07345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS07390	COG0745	RESPONSE REGULATOR receiver
I3J07_RS07405	COG0183	Belongs to the thiolase family
I3J07_RS07425	COG1131	(ABC) transporter
I3J07_RS07460	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J07_RS07475	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J07_RS07490	COG4585	Histidine kinase
I3J07_RS07495	COG2197	response regulator
I3J07_RS07505	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J07_RS07525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J07_RS07555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J07_RS07565	COG0494	nUDIX hydrolase
I3J07_RS07580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J07_RS07585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J07_RS07590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J07_RS07595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J07_RS07600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J07_RS07605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J07_RS07610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J07_RS07630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J07_RS07635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J07_RS07645	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J07_RS07650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J07_RS07655	COG0254	rRNA binding
I3J07_RS07660	COG1316	TRANSCRIPTIONal
I3J07_RS07675	COG0083	homoserine kinase activity
I3J07_RS07680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J07_RS07685	COG0460	homoserine dehydrogenase
I3J07_RS07690	COG0019	diaminopimelate decarboxylase activity
I3J07_RS07695	COG0018	arginyl-trna synthetase
I3J07_RS07835	COG2367	Beta-lactamase
I3J07_RS07840	COG1686	Belongs to the peptidase S11 family
I3J07_RS07850	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS07855	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J07_RS07860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J07_RS07880	COG2192	nodulation
I3J07_RS07890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J07_RS07900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J07_RS07910	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J07_RS07920	COG0768	penicillin binding
I3J07_RS07930	COG0367	asparagine synthase
I3J07_RS07935	COG0010	Belongs to the arginase family
I3J07_RS07940	COG2175	clavaminate synthase activity
I3J07_RS07980	COG0697	spore germination
I3J07_RS07985	COG0456	acetyltransferase
I3J07_RS07990	COG0747	negative chemotaxis
I3J07_RS08000	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J07_RS08005	COG0768	penicillin binding
I3J07_RS08010	COG0768	penicillin binding
I3J07_RS08015	COG2124	cytochrome p450
I3J07_RS08025	COG2205	protein histidine kinase activity
I3J07_RS08030	COG0745	RESPONSE REGULATOR receiver
I3J07_RS08050	COG2072	flavoprotein involved in K transport
I3J07_RS08055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J07_RS08060	COG3285	dna ligase
I3J07_RS08060	COG1793	dna ligase
I3J07_RS08065	COG1793	dna ligase
I3J07_RS08120	COG0768	penicillin binding
I3J07_RS08150	COG2318	DinB family
I3J07_RS08185	COG2205	protein histidine kinase activity
I3J07_RS08205	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J07_RS08210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J07_RS08220	COG0745	RESPONSE REGULATOR receiver
I3J07_RS08225	COG2205	protein histidine kinase activity
I3J07_RS08230	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J07_RS08230	COG0567	Dehydrogenase, E1 component
I3J07_RS08240	COG2255	four-way junction helicase activity
I3J07_RS08275	COG0604	alcohol dehydrogenase
I3J07_RS08295	COG1126	abc transporter atp-binding protein
I3J07_RS08300	COG4106	trans-aconitate 2-methyltransferase activity
I3J07_RS08320	COG0494	nUDIX hydrolase
I3J07_RS08330	COG5640	endopeptidase activity
I3J07_RS08350	COG0142	geranyltranstransferase activity
I3J07_RS08385	COG1597	lipid kinase activity
I3J07_RS08400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J07_RS08405	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J07_RS08410	COG0395	ABC-type sugar transport system, permease component
I3J07_RS08415	COG1175	transmembrane transport
I3J07_RS08420	COG2182	Extracellular solute-binding protein
I3J07_RS08425	COG2188	Transcriptional regulator
I3J07_RS08450	COG0242	peptide deformylase activity
I3J07_RS08470	COG5662	AntiSigma factor
I3J07_RS08475	COG1595	DNA-templated transcription, initiation
I3J07_RS08485	COG2135	peptidase activity
I3J07_RS08495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J07_RS08505	COG2076	Multidrug Resistance protein
I3J07_RS08515	COG0483	inositol monophosphate 1-phosphatase activity
I3J07_RS08525	COG0753	catalase activity
I3J07_RS08550	COG1615	UPF0182 protein
I3J07_RS08560	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J07_RS08600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J07_RS08640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J07_RS08695	COG0601	transmembrane transport
I3J07_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS08705	COG0747	negative chemotaxis
I3J07_RS08715	COG0596	Alpha beta hydrolase
I3J07_RS08715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J07_RS08745	COG0513	Belongs to the DEAD box helicase family
I3J07_RS08770	COG1432	Conserved Protein
I3J07_RS08780	COG2095	MarC family integral membrane protein
I3J07_RS08800	COG0598	Magnesium transport protein CorA
I3J07_RS08835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J07_RS08840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J07_RS08850	COG1595	DNA-templated transcription, initiation
I3J07_RS08865	COG1024	Enoyl-CoA hydratase
I3J07_RS08870	COG0519	Catalyzes the synthesis of GMP from XMP
I3J07_RS08880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J07_RS08885	COG1611	Belongs to the LOG family
I3J07_RS08890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J07_RS08930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J07_RS08945	COG4608	Belongs to the ABC transporter superfamily
I3J07_RS08950	COG0444	Belongs to the ABC transporter superfamily
I3J07_RS08955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS08960	COG0601	transmembrane transport
I3J07_RS08975	COG4608	Belongs to the ABC transporter superfamily
I3J07_RS08980	COG0444	Belongs to the ABC transporter superfamily
I3J07_RS08990	COG4166	transmembrane transport
I3J07_RS08995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J07_RS09000	COG1217	gtp-binding protein TYPA
I3J07_RS09020	COG1053	succinate dehydrogenase
I3J07_RS09070	COG0012	GTP binding
I3J07_RS09085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J07_RS09090	COG0531	amino acid
I3J07_RS09095	COG1570	exodeoxyribonuclease VII activity
I3J07_RS09100	COG1722	exodeoxyribonuclease VII activity
I3J07_RS09105	COG0778	Nitroreductase
I3J07_RS09130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J07_RS09130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J07_RS09140	COG0114	fumarate hydratase activity
I3J07_RS09160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J07_RS09180	COG1136	(ABC) transporter
I3J07_RS09195	COG0450	alkyl hydroperoxide reductase
I3J07_RS09200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J07_RS09215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J07_RS09220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J07_RS09225	COG0667	Aldo Keto reductase
I3J07_RS09250	COG2885	chlorophyll binding
I3J07_RS09275	COG4585	Histidine kinase
I3J07_RS09305	COG2894	cell division
I3J07_RS09330	COG2610	gluconate transmembrane transporter activity
I3J07_RS09335	COG0251	oxidation-reduction process
I3J07_RS09340	COG1414	Transcriptional regulator
I3J07_RS09355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J07_RS09415	COG0492	ferredoxin-NADP+ reductase activity
I3J07_RS09450	COG0728	peptidoglycan biosynthetic process
I3J07_RS09460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J07_RS09465	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS09505	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J07_RS09515	COG1309	transcriptional regulator
I3J07_RS09520	COG1331	Highly conserved protein containing a thioredoxin domain
I3J07_RS09550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J07_RS09560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J07_RS09570	COG2188	Transcriptional regulator
I3J07_RS09590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J07_RS09630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J07_RS09650	COG1064	alcohol dehydrogenase
I3J07_RS09665	COG2986	histidine ammonia-lyase
I3J07_RS09675	COG1024	Enoyl-CoA hydratase
I3J07_RS09690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J07_RS09700	COG0424	maF-like protein
I3J07_RS09705	COG4770	biotin carboxylase activity
I3J07_RS09735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J07_RS09765	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS09770	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS09785	COG1595	DNA-templated transcription, initiation
I3J07_RS09790	COG0745	RESPONSE REGULATOR receiver
I3J07_RS09795	COG2205	protein histidine kinase activity
I3J07_RS09820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J07_RS09835	COG0583	DNA-binding transcription factor activity
I3J07_RS09840	COG2814	Major facilitator Superfamily
I3J07_RS09875	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J07_RS09880	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J07_RS09885	COG3845	ABC transporter
I3J07_RS09890	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J07_RS09895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J07_RS09895	COG1473	amidohydrolase
I3J07_RS09905	COG2089	acid synthase
I3J07_RS09910	COG1083	cytidylyl-transferase
I3J07_RS09920	COG1216	Glycosyl transferase, family 2
I3J07_RS09935	COG0517	IMP dehydrogenase activity
I3J07_RS09935	COG0516	GMP reductase activity
I3J07_RS09950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS09950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS09965	COG1595	DNA-templated transcription, initiation
I3J07_RS09975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J07_RS09980	COG2009	succinate dehydrogenase
I3J07_RS09990	COG1053	succinate dehydrogenase
I3J07_RS09995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J07_RS10005	COG1408	metallophosphoesterase
I3J07_RS10015	COG1686	Belongs to the peptidase S11 family
I3J07_RS10020	COG1295	ribonuclease BN
I3J07_RS10025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J07_RS10050	COG0180	Tryptophanyl-tRNA synthetase
I3J07_RS10055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J07_RS10060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J07_RS10065	COG0754	glutathionylspermidine amidase activity
I3J07_RS10075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J07_RS10115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J07_RS10125	COG0039	L-malate dehydrogenase activity
I3J07_RS10140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J07_RS10155	COG0138	bifunctional purine biosynthesis protein purh
I3J07_RS10185	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J07_RS10190	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J07_RS10200	COG0714	Associated with various cellular activities
I3J07_RS10215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS10215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J07_RS10225	COG0739	heme binding
I3J07_RS10245	COG2197	response regulator
I3J07_RS10270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J07_RS10270	COG0519	Catalyzes the synthesis of GMP from XMP
I3J07_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS10310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J07_RS10320	COG0516	GMP reductase activity
I3J07_RS10330	COG1595	DNA-templated transcription, initiation
I3J07_RS10335	COG2197	response regulator
I3J07_RS10345	COG0583	DNA-binding transcription factor activity
I3J07_RS10360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J07_RS10365	COG0459	protein refolding
I3J07_RS10370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J07_RS10375	COG0726	polysaccharide deacetylase
I3J07_RS10385	COG4941	Belongs to the sigma-70 factor family
I3J07_RS10410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J07_RS10435	COG0802	atpase or kinase
I3J07_RS10445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J07_RS10465	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J07_RS10470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J07_RS10475	COG1072	(Pantothenic acid kinase))
I3J07_RS10480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J07_RS10485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J07_RS10490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J07_RS10495	COG0488	(ABC) transporter
I3J07_RS10505	COG0101	tRNA pseudouridine synthase activity
I3J07_RS10510	COG0203	ribosomal protein L17
I3J07_RS10515	COG0202	RNA polymerase activity
I3J07_RS10520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J07_RS10525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J07_RS10530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J07_RS10535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J07_RS10545	COG0563	adenylate kinase activity
I3J07_RS10555	COG0200	Binds to the 23S rRNA
I3J07_RS10560	COG1841	ribosomal large subunit assembly
I3J07_RS10565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J07_RS10570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J07_RS10575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J07_RS10580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J07_RS10585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J07_RS10590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J07_RS10595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J07_RS10600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J07_RS10605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J07_RS10610	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J07_RS10615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J07_RS10620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J07_RS10625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J07_RS10630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J07_RS10635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J07_RS10640	COG0089	rRNA binding
I3J07_RS10645	COG0088	Forms part of the polypeptide exit tunnel
I3J07_RS10650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J07_RS10655	COG0051	transcription antitermination factor activity, RNA binding
I3J07_RS10665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J07_RS10670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J07_RS10675	COG0049	tRNA binding
I3J07_RS10680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J07_RS10685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J07_RS10690	COG0085	RNA polymerase activity
I3J07_RS10695	COG0222	ribosome binding
I3J07_RS10700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J07_RS10705	COG0081	regulation of translation
I3J07_RS10710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J07_RS10720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J07_RS10730	COG0436	Aminotransferase
I3J07_RS10735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J07_RS10740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J07_RS10750	COG2030	dehydratase
I3J07_RS10755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J07_RS10775	COG0702	epimerase
I3J07_RS10795	COG1666	GTP binding
I3J07_RS10800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J07_RS10810	COG3304	Inner membrane component domain
I3J07_RS10815	COG0501	Belongs to the peptidase M48B family
I3J07_RS10820	COG1007	ATP synthesis coupled electron transport
I3J07_RS10835	COG0713	ATP synthesis coupled electron transport
I3J07_RS10840	COG0839	Belongs to the complex I subunit 6 family
I3J07_RS10845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS10850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J07_RS10855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS10860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS10865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS10870	COG4585	Histidine kinase
I3J07_RS10885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J07_RS10885	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J07_RS10890	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J07_RS10915	COG1733	regulation of RNA biosynthetic process
I3J07_RS10930	COG4935	Belongs to the peptidase S8 family
I3J07_RS10930	COG2234	aminopeptidase activity
I3J07_RS10955	COG0142	geranyltranstransferase activity
I3J07_RS10960	COG2936	dipeptidyl-peptidase activity
I3J07_RS10965	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J07_RS10970	COG1007	ATP synthesis coupled electron transport
I3J07_RS10980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J07_RS10985	COG0713	ATP synthesis coupled electron transport
I3J07_RS10990	COG0839	Belongs to the complex I subunit 6 family
I3J07_RS10995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS11000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J07_RS11005	COG1034	ATP synthesis coupled electron transport
I3J07_RS11010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J07_RS11020	COG0649	NAD binding
I3J07_RS11025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS11030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J07_RS11060	COG2226	methyltransferase
I3J07_RS11070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J07_RS11075	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J07_RS11080	COG1278	Cold shock
I3J07_RS11085	COG1823	symporter activity
I3J07_RS11105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J07_RS11115	COG0163	prenyltransferase activity
I3J07_RS11120	COG0109	protoheme IX farnesyltransferase activity
I3J07_RS11125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J07_RS11135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J07_RS11140	COG1333	cytochrome c biogenesis protein
I3J07_RS11145	COG0785	Cytochrome C biogenesis protein
I3J07_RS11150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J07_RS11155	COG0406	alpha-ribazole phosphatase activity
I3J07_RS11160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J07_RS11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J07_RS11185	COG1742	UPF0060 membrane protein
I3J07_RS11200	COG0402	S-adenosylhomocysteine deaminase activity
I3J07_RS11205	COG1690	Belongs to the RtcB family
I3J07_RS11245	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J07_RS11250	COG0626	cystathionine gamma-synthase activity
I3J07_RS11265	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J07_RS11270	COG0018	arginyl-trna synthetase
I3J07_RS11290	COG0113	porphobilinogen synthase activity
I3J07_RS11395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J07_RS11400	COG0596	Alpha beta hydrolase
I3J07_RS11425	COG1136	(ABC) transporter
I3J07_RS11500	COG1725	Transcriptional regulator
I3J07_RS11520	COG1309	transcriptional regulator
I3J07_RS11540	COG0702	epimerase
I3J07_RS11550	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS11575	COG0259	pyridoxamine-phosphate oxidase activity
I3J07_RS11590	COG2072	flavoprotein involved in K transport
I3J07_RS11600	COG1024	Enoyl-CoA hydratase
I3J07_RS11610	COG0456	acetyltransferase
I3J07_RS11615	COG2814	Major facilitator Superfamily
I3J07_RS11615	COG0477	Major facilitator Superfamily
I3J07_RS11620	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J07_RS11635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J07_RS11640	COG2271	Major facilitator Superfamily
I3J07_RS11645	COG4977	sequence-specific DNA binding
I3J07_RS11645	COG1917	Cupin 2, conserved barrel domain protein
I3J07_RS11655	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS11675	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS11680	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS11695	COG3397	chitin binding
I3J07_RS11765	COG0596	Alpha beta hydrolase
I3J07_RS11765	COG2945	thiolester hydrolase activity
I3J07_RS11775	COG4821	SIS domain
I3J07_RS11785	COG0259	pyridoxamine-phosphate oxidase activity
I3J07_RS11805	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS11820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J07_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS11930	COG0726	polysaccharide deacetylase
I3J07_RS11960	COG0577	efflux transmembrane transporter activity
I3J07_RS11965	COG0577	efflux transmembrane transporter activity
I3J07_RS11965	COG1136	(ABC) transporter
I3J07_RS12000	COG0583	DNA-binding transcription factor activity
I3J07_RS12015	COG2205	protein histidine kinase activity
I3J07_RS12020	COG0745	RESPONSE REGULATOR receiver
I3J07_RS12035	COG0277	FAD linked oxidase domain protein
I3J07_RS12035	COG0247	lactate metabolic process
I3J07_RS12045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J07_RS12085	COG0463	Glycosyl transferase, family 2
I3J07_RS12095	COG3903	Transcriptional regulator
I3J07_RS12095	COG3629	intracellular signal transduction
I3J07_RS12110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J07_RS12150	COG1122	ATPase activity
I3J07_RS12170	COG0667	Aldo Keto reductase
I3J07_RS12205	COG2252	PERMEase
I3J07_RS12215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J07_RS12235	COG2814	Major facilitator Superfamily
I3J07_RS12245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J07_RS12250	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J07_RS12255	COG1278	Cold shock
I3J07_RS12290	COG1061	Type III restriction enzyme res subunit
I3J07_RS12300	COG3973	AAA domain
I3J07_RS12315	COG1595	DNA-templated transcription, initiation
I3J07_RS12390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J07_RS12395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J07_RS12405	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS12410	COG1605	Chorismate mutase
I3J07_RS12430	COG2197	response regulator
I3J07_RS12450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J07_RS12475	COG0191	fructose-bisphosphate aldolase activity
I3J07_RS12480	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J07_RS12495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J07_RS12500	COG2182	Extracellular solute-binding protein
I3J07_RS12525	COG0463	Glycosyl transferase, family 2
I3J07_RS12590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J07_RS12605	COG3842	ATPase activity
I3J07_RS12615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J07_RS12625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J07_RS12630	COG0215	cysteine-tRNA ligase activity
I3J07_RS12640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J07_RS12645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J07_RS12650	COG1329	Transcriptional regulator
I3J07_RS12665	COG5002	protein histidine kinase activity
I3J07_RS12680	COG0588	phosphoglycerate mutase activity
I3J07_RS12685	COG2211	Major facilitator Superfamily
I3J07_RS12710	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS12770	COG1490	D-aminoacyl-tRNA deacylase activity
I3J07_RS12785	COG3485	protocatechuate 3,4-dioxygenase
I3J07_RS12810	COG1309	transcriptional regulator
I3J07_RS12830	COG0745	RESPONSE REGULATOR receiver
I3J07_RS12835	COG1609	Transcriptional regulator
I3J07_RS12850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J07_RS12865	COG2188	Transcriptional regulator
I3J07_RS12875	COG1525	nuclease
I3J07_RS12875	COG4085	toxin activity
I3J07_RS12875	COG0737	Belongs to the 5'-nucleotidase family
I3J07_RS12895	COG0456	acetyltransferase
I3J07_RS12900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J07_RS12910	COG0406	alpha-ribazole phosphatase activity
I3J07_RS12910	COG0494	nUDIX hydrolase
I3J07_RS12935	COG0306	phosphate transporter
I3J07_RS12945	COG1937	Protein conserved in bacteria
I3J07_RS12965	COG0671	phosphoesterase, PA-phosphatase related
I3J07_RS12970	COG0739	heme binding
I3J07_RS12970	COG0741	lytic transglycosylase activity
I3J07_RS12970	COG1196	nuclear chromosome segregation
I3J07_RS13065	COG0579	oxidoreductase
I3J07_RS13070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J07_RS13080	COG0739	heme binding
I3J07_RS13080	COG0741	lytic transglycosylase activity
I3J07_RS13080	COG1196	nuclear chromosome segregation
I3J07_RS13135	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J07_RS13145	COG0513	Belongs to the DEAD box helicase family
I3J07_RS13155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J07_RS13160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J07_RS13195	COG0785	Cytochrome C biogenesis protein
I3J07_RS13200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J07_RS13200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J07_RS13210	COG1643	Atp-dependent helicase
I3J07_RS13245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J07_RS13275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J07_RS13280	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J07_RS13285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J07_RS13320	COG2197	response regulator
I3J07_RS13330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J07_RS13345	COG0151	Belongs to the GarS family
I3J07_RS13370	COG0017	Asparaginyl-tRNA synthetase
I3J07_RS13375	COG1051	belongs to the nudix hydrolase family
I3J07_RS13385	COG0105	UTP biosynthetic process
I3J07_RS13425	COG2826	transposase and inactivated derivatives, IS30 family
I3J07_RS13455	COG3903	Transcriptional regulator
I3J07_RS13455	COG3629	intracellular signal transduction
I3J07_RS13520	COG0477	Major facilitator Superfamily
I3J07_RS13550	COG2234	aminopeptidase activity
I3J07_RS13555	COG0433	COG0433 Predicted ATPase
I3J07_RS13570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J07_RS13615	COG1191	sigma factor activity
I3J07_RS13620	COG1191	sigma factor activity
I3J07_RS13670	COG2304	oxidoreductase activity
I3J07_RS13675	COG2205	protein histidine kinase activity
I3J07_RS13680	COG0745	RESPONSE REGULATOR receiver
I3J07_RS13685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J07_RS13705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J07_RS13730	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS13740	COG1362	aminopeptidase activity
I3J07_RS13760	COG2271	Major facilitator Superfamily
I3J07_RS13775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J07_RS13780	COG0022	dehydrogenase e1 component
I3J07_RS13805	COG0515	serine threonine protein kinase
I3J07_RS13810	COG0515	serine threonine protein kinase
I3J07_RS13825	COG1136	(ABC) transporter
I3J07_RS13825	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J07_RS13855	COG0303	'Molybdopterin
I3J07_RS13880	COG1522	sequence-specific DNA binding
I3J07_RS13885	COG1309	transcriptional regulator
I3J07_RS13890	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J07_RS13915	COG3396	Phenylacetate-CoA oxygenase
I3J07_RS13920	COG3460	Phenylacetate-CoA oxygenase
I3J07_RS13925	COG3396	Phenylacetate-CoA oxygenase
I3J07_RS13930	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J07_RS13935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J07_RS13940	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS13945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J07_RS13960	COG2197	response regulator
I3J07_RS13965	COG4585	Histidine kinase
I3J07_RS13990	COG1136	(ABC) transporter
I3J07_RS13990	COG0577	efflux transmembrane transporter activity
I3J07_RS13995	COG0577	efflux transmembrane transporter activity
I3J07_RS13995	COG1136	(ABC) transporter
I3J07_RS14005	COG1716	ATPase activity
I3J07_RS14010	COG1716	ATPase activity
I3J07_RS14025	COG0768	penicillin binding
I3J07_RS14030	COG0515	serine threonine protein kinase
I3J07_RS14035	COG3764	Sortase (surface protein transpeptidase)
I3J07_RS14040	COG3764	Sortase (surface protein transpeptidase)
I3J07_RS14055	COG3764	Sortase (surface protein transpeptidase)
I3J07_RS14070	COG0457	Tetratricopeptide repeat
I3J07_RS14070	COG0705	Rhomboid family
I3J07_RS14100	COG1446	asparaginase
I3J07_RS14105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J07_RS14110	COG1280	lysine exporter protein (LysE YggA)
I3J07_RS14115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J07_RS14115	COG1672	PFAM Archaeal ATPase
I3J07_RS14130	COG0667	Aldo Keto reductase
I3J07_RS14135	COG2175	clavaminate synthase activity
I3J07_RS14140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J07_RS14145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS14150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS14165	COG0515	serine threonine protein kinase
I3J07_RS14185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J07_RS14195	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J07_RS14200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J07_RS14205	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J07_RS14210	COG0592	DNA-directed DNA polymerase activity
I3J07_RS14220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J07_RS14225	COG0594	ribonuclease P activity
I3J07_RS14230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J07_RS14235	COG0706	membrane insertase activity
I3J07_RS14245	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J07_RS14250	COG1192	Involved in chromosome partitioning
I3J07_RS14265	COG3118	belongs to the thioredoxin family
I3J07_RS14270	COG0492	ferredoxin-NADP+ reductase activity
I3J07_RS14280	COG1595	DNA-templated transcription, initiation
I3J07_RS14285	COG2815	serine threonine protein kinase
I3J07_RS14285	COG0515	serine threonine protein kinase
I3J07_RS14300	COG0617	tRNA 3'-terminal CCA addition
I3J07_RS14320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J07_RS14345	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J07_RS14350	COG0629	single-stranded DNA binding
I3J07_RS14355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J07_RS14360	COG0359	binds to the 23S rRNA
I3J07_RS14370	COG0305	Participates in initiation and elongation during chromosome replication
I3J07_RS14405	COG0626	cystathionine gamma-synthase activity
I3J07_RS14410	COG1950	PFAM Membrane protein of
I3J07_RS14415	COG0662	Cupin 2, conserved barrel domain protein
I3J07_RS14435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J07_RS14450	COG1609	Transcriptional regulator
I3J07_RS14455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J07_RS14460	COG1271	oxidase subunit
I3J07_RS14465	COG1294	oxidase, subunit
I3J07_RS14470	COG4988	ABC transporter
I3J07_RS14480	COG0561	phosphatase activity
I3J07_RS14490	COG1131	(ABC) transporter
I3J07_RS14525	COG0561	phosphatase activity
I3J07_RS14530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J07_RS14535	COG0077	Prephenate dehydratase
I3J07_RS14540	COG2837	iron assimilation
I3J07_RS14555	COG1999	signal sequence binding
I3J07_RS14575	COG0006	proline dipeptidase activity
I3J07_RS14605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J07_RS14635	COG0587	DNA-directed DNA polymerase activity
I3J07_RS14640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J07_RS14665	COG1595	DNA-templated transcription, initiation
I3J07_RS14670	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS14675	COG0784	Response regulator, receiver
I3J07_RS14705	COG0745	RESPONSE REGULATOR receiver
I3J07_RS14710	COG0477	Major facilitator Superfamily
I3J07_RS14730	COG0431	NADPH-dependent FMN reductase
I3J07_RS14755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J07_RS14755	COG1672	PFAM Archaeal ATPase
I3J07_RS14760	COG0431	NADPH-dependent FMN reductase
I3J07_RS14790	COG0598	Magnesium transport protein CorA
I3J07_RS14795	COG3345	alpha-galactosidase
I3J07_RS14875	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J07_RS14885	COG2226	methyltransferase
I3J07_RS14890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J07_RS14930	COG2826	transposase and inactivated derivatives, IS30 family
I3J07_RS15035	COG1857	crispr-associated protein
I3J07_RS15055	COG0436	Aminotransferase
I3J07_RS15070	COG2197	response regulator
I3J07_RS15080	COG0577	efflux transmembrane transporter activity
I3J07_RS15140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J07_RS15165	COG3903	Transcriptional regulator
I3J07_RS15165	COG3629	intracellular signal transduction
I3J07_RS15215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J07_RS15225	COG0534	Mate efflux family protein
I3J07_RS15230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J07_RS15235	COG0019	diaminopimelate decarboxylase activity
I3J07_RS15250	COG4166	transmembrane transport
I3J07_RS15255	COG0601	transmembrane transport
I3J07_RS15260	COG4171	peptide transport system, permease
I3J07_RS15275	COG2197	response regulator
I3J07_RS15280	COG4585	Histidine kinase
I3J07_RS15285	COG2409	Drug exporters of the RND superfamily
I3J07_RS15310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J07_RS15320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J07_RS15325	COG0588	phosphoglycerate mutase activity
I3J07_RS15375	COG0717	Belongs to the dCTP deaminase family
I3J07_RS15390	COG2181	nitrate reductase activity
I3J07_RS15390	COG0247	lactate metabolic process
I3J07_RS15395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J07_RS15400	COG0443	Heat shock 70 kDa protein
I3J07_RS15405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J07_RS15410	COG0484	heat shock protein binding
I3J07_RS15415	COG0789	Transcriptional regulator
I3J07_RS15435	COG0542	response to heat
I3J07_RS15465	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J07_RS15480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J07_RS15485	COG0191	fructose-bisphosphate aldolase activity
I3J07_RS15490	COG0477	Major facilitator Superfamily
I3J07_RS15525	COG4585	Histidine kinase
I3J07_RS15535	COG2124	cytochrome p450
I3J07_RS15565	COG0463	Glycosyl transferase, family 2
I3J07_RS15570	COG1802	Transcriptional regulator
I3J07_RS15585	COG2319	Wd-40 repeat
I3J07_RS15585	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J07_RS15590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS15625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J07_RS15640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J07_RS15645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J07_RS15660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J07_RS15665	COG1595	DNA-templated transcription, initiation
I3J07_RS15690	COG2124	cytochrome p450
I3J07_RS15705	COG2091	lysine biosynthetic process via aminoadipic acid
I3J07_RS15720	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J07_RS15750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J07_RS15835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J07_RS15855	COG1408	metallophosphoesterase
I3J07_RS15860	COG1610	YqeY-like protein
I3J07_RS15865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J07_RS15875	COG0003	Pfam Anion-transporting ATPase
I3J07_RS15905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J07_RS15935	COG2267	carboxylic ester hydrolase activity
I3J07_RS15945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J07_RS15950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J07_RS15955	COG0659	secondary active sulfate transmembrane transporter activity
I3J07_RS16015	COG1111	helicase
I3J07_RS16015	COG1205	dead DEAH box helicase
I3J07_RS16020	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J07_RS16025	COG2172	sigma factor antagonist activity
I3J07_RS16030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J07_RS16040	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J07_RS16050	COG1754	DNA topoisomerase type I activity
I3J07_RS16050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J07_RS16055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J07_RS16060	COG0470	DNA polymerase III
I3J07_RS16070	COG0477	Major facilitator Superfamily
I3J07_RS16110	COG1061	Type III restriction enzyme res subunit
I3J07_RS16155	COG0791	NLP P60 protein
I3J07_RS16235	COG0305	Participates in initiation and elongation during chromosome replication
I3J07_RS16395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J07_RS16505	COG1132	(ABC) transporter
I3J07_RS16510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J07_RS16510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J07_RS16515	COG0110	maltose O-acetyltransferase activity
I3J07_RS16555	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS16560	COG2318	DinB family
I3J07_RS16575	COG0076	glutamate decarboxylase activity
I3J07_RS16590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J07_RS16595	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J07_RS16605	COG0037	tRNA processing
I3J07_RS16620	COG0302	gtp cyclohydrolase
I3J07_RS16635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J07_RS16660	COG1174	glycine betaine transport
I3J07_RS16675	COG0649	NAD binding
I3J07_RS16690	COG2197	response regulator
I3J07_RS16705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J07_RS16710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J07_RS16720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J07_RS16740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J07_RS16755	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J07_RS16765	COG0739	heme binding
I3J07_RS16770	COG2205	protein histidine kinase activity
I3J07_RS16775	COG0745	RESPONSE REGULATOR receiver
I3J07_RS16785	COG1595	DNA-templated transcription, initiation
I3J07_RS16790	COG1194	a g-specific adenine glycosylase
I3J07_RS16795	COG0671	phosphoesterase, PA-phosphatase related
I3J07_RS16805	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J07_RS16825	COG0248	Ppx GppA phosphatase
I3J07_RS16835	COG0129	dihydroxy-acid dehydratase activity
I3J07_RS16855	COG2226	methyltransferase
I3J07_RS16860	COG1595	DNA-templated transcription, initiation
I3J07_RS16865	COG1252	NADH dehydrogenase
I3J07_RS16870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J07_RS16875	COG0180	Tryptophanyl-tRNA synthetase
I3J07_RS16900	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J07_RS16935	COG1595	DNA-templated transcription, initiation
I3J07_RS16950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J07_RS16955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J07_RS16960	COG0181	hydroxymethylbilane synthase activity
I3J07_RS16965	COG1648	precorrin-2 dehydrogenase activity
I3J07_RS16965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J07_RS16990	COG1846	Transcriptional regulator
I3J07_RS16995	COG3384	dioxygenase
I3J07_RS17015	COG0477	Major facilitator Superfamily
I3J07_RS17025	COG3191	aminopeptidase activity
I3J07_RS17040	COG1970	mechanosensitive ion channel activity
I3J07_RS17050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J07_RS17075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J07_RS17080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J07_RS17090	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J07_RS17095	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J07_RS17095	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J07_RS17100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J07_RS17145	COG2072	flavoprotein involved in K transport
I3J07_RS17150	COG2267	carboxylic ester hydrolase activity
I3J07_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS17160	COG4946	Tricorn protease homolog
I3J07_RS17160	COG0793	Belongs to the peptidase S41A family
I3J07_RS17170	COG2409	Drug exporters of the RND superfamily
I3J07_RS17180	COG0310	cobalt ion transport
I3J07_RS17190	COG1122	ATPase activity
I3J07_RS17195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J07_RS17235	COG0124	histidyl-tRNA synthetase
I3J07_RS17260	COG3409	Peptidoglycan-binding domain 1 protein
I3J07_RS17265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J07_RS17285	COG0442	prolyl-tRNA aminoacylation
I3J07_RS17315	COG0084	hydrolase, TatD family'
I3J07_RS17325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J07_RS17330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J07_RS17355	COG0488	(ABC) transporter
I3J07_RS17385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J07_RS17390	COG2197	response regulator
I3J07_RS17400	COG4106	trans-aconitate 2-methyltransferase activity
I3J07_RS17405	COG1309	transcriptional regulator
I3J07_RS17415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J07_RS17425	COG0193	aminoacyl-tRNA hydrolase activity
I3J07_RS17430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J07_RS17435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J07_RS17440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J07_RS17450	COG4585	Histidine kinase
I3J07_RS17480	COG0477	Major facilitator Superfamily
I3J07_RS17495	COG1136	(ABC) transporter
I3J07_RS17500	COG0577	efflux transmembrane transporter activity
I3J07_RS17510	COG1595	DNA-templated transcription, initiation
I3J07_RS17535	COG2815	serine threonine protein kinase
I3J07_RS17535	COG0515	serine threonine protein kinase
I3J07_RS17565	COG1652	LysM domain
I3J07_RS17575	COG0148	phosphopyruvate hydratase activity
I3J07_RS17595	COG1252	NADH dehydrogenase
I3J07_RS17600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J07_RS17605	COG0577	efflux transmembrane transporter activity
I3J07_RS17605	COG1136	(ABC) transporter
I3J07_RS17610	COG1136	(ABC) transporter
I3J07_RS17610	COG0577	efflux transmembrane transporter activity
I3J07_RS17640	COG0183	Belongs to the thiolase family
I3J07_RS17645	COG2755	lipolytic protein G-D-S-L family
I3J07_RS17660	COG1737	Transcriptional regulator
I3J07_RS17720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J07_RS17750	COG1228	amidohydrolase
I3J07_RS17775	COG1191	sigma factor activity
I3J07_RS17800	COG3104	oligopeptide transport
I3J07_RS17805	COG0745	RESPONSE REGULATOR receiver
I3J07_RS17810	COG2205	protein histidine kinase activity
I3J07_RS17845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J07_RS17930	COG1309	transcriptional regulator
I3J07_RS17935	COG0596	Alpha beta hydrolase
I3J07_RS17940	COG1316	TRANSCRIPTIONal
I3J07_RS17945	COG1607	acyl-coa hydrolase
I3J07_RS17950	COG1316	TRANSCRIPTIONal
I3J07_RS17970	COG1316	TRANSCRIPTIONal
I3J07_RS17995	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J07_RS17995	COG0778	Nitroreductase
I3J07_RS18000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J07_RS18035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J07_RS18040	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J07_RS18050	COG1482	cell wall glycoprotein biosynthetic process
I3J07_RS18060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J07_RS18085	COG2826	transposase and inactivated derivatives, IS30 family
I3J07_RS18095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J07_RS18100	COG0745	RESPONSE REGULATOR receiver
I3J07_RS18105	COG5000	phosphorelay sensor kinase activity
I3J07_RS18105	COG5002	protein histidine kinase activity
I3J07_RS18110	COG0823	Involved in the tonB-independent uptake of proteins
I3J07_RS18120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J07_RS18125	COG2197	response regulator
I3J07_RS18130	COG3214	Protein conserved in bacteria
I3J07_RS18140	COG0653	protein targeting
I3J07_RS18165	COG2902	Dehydrogenase
I3J07_RS18175	COG0395	ABC-type sugar transport system, permease component
I3J07_RS18180	COG1175	transmembrane transport
I3J07_RS18195	COG0515	serine threonine protein kinase
I3J07_RS18200	COG0515	serine threonine protein kinase
I3J07_RS18205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J07_RS18215	COG2884	Cell division ATP-binding protein ftsE
I3J07_RS18225	COG0793	Belongs to the peptidase S41A family
I3J07_RS18230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J07_RS18245	COG0583	DNA-binding transcription factor activity
I3J07_RS18270	COG3973	AAA domain
I3J07_RS18280	COG0776	regulation of translation
I3J07_RS18285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J07_RS18290	COG1678	Uncharacterized ACR, COG1678
I3J07_RS18305	COG1175	transmembrane transport
I3J07_RS18310	COG0395	ABC-type sugar transport system, permease component
I3J07_RS18315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J07_RS18355	COG3654	unkown
I3J07_RS18380	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J07_RS18385	COG0745	RESPONSE REGULATOR receiver
I3J07_RS18390	COG5002	protein histidine kinase activity
I3J07_RS18410	COG0277	FAD linked oxidase domain protein
I3J07_RS18450	COG1335	isochorismatase
I3J07_RS18460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J07_RS18470	COG1113	amino acid transport
I3J07_RS18480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J07_RS18485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS18490	COG1120	ATPase activity
I3J07_RS18505	COG1234	tRNA 3'-trailer cleavage
I3J07_RS18510	COG1263	PTS System
I3J07_RS18515	COG1263	PTS System
I3J07_RS18520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J07_RS18525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J07_RS18535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J07_RS18565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J07_RS18575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J07_RS18600	COG2733	membrane
I3J07_RS18630	COG0706	membrane insertase activity
I3J07_RS18640	COG0673	inositol 2-dehydrogenase activity
I3J07_RS18710	COG1126	abc transporter atp-binding protein
I3J07_RS18715	COG0765	amino acid transport
I3J07_RS18720	COG0765	amino acid transport
I3J07_RS18730	COG0154	amidase activity
I3J07_RS18740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS18775	COG0406	alpha-ribazole phosphatase activity
I3J07_RS18815	COG0745	RESPONSE REGULATOR receiver
I3J07_RS18830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J07_RS18835	COG4977	sequence-specific DNA binding
I3J07_RS18845	COG0589	response to stress
I3J07_RS18850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J07_RS18875	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J07_RS18880	COG0076	glutamate decarboxylase activity
I3J07_RS18890	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS18905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J07_RS18910	COG1309	transcriptional regulator
I3J07_RS18920	COG2124	cytochrome p450
I3J07_RS18925	COG1946	Acyl-CoA thioesterase
I3J07_RS18940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J07_RS18950	COG3960	tartronate-semialdehyde synthase activity
I3J07_RS18970	COG1674	ftsk spoiiie
I3J07_RS19035	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J07_RS19050	COG1609	Transcriptional regulator
I3J07_RS19055	COG0673	inositol 2-dehydrogenase activity
I3J07_RS19070	COG1595	DNA-templated transcription, initiation
I3J07_RS19080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J07_RS19105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J07_RS19115	COG3718	enzyme involved in inositol metabolism
I3J07_RS19120	COG3962	Belongs to the TPP enzyme family
I3J07_RS19140	COG1131	(ABC) transporter
I3J07_RS19200	COG0105	UTP biosynthetic process
I3J07_RS19205	COG2197	response regulator
I3J07_RS19215	COG2954	triphosphatase activity
I3J07_RS19225	COG0494	nUDIX hydrolase
I3J07_RS19255	COG0561	phosphatase activity
I3J07_RS19265	COG0475	glutathione-regulated potassium exporter activity
I3J07_RS19295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J07_RS19305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J07_RS19310	COG1518	maintenance of DNA repeat elements
I3J07_RS19320	COG1203	CRISPR-associated helicase, Cas3
I3J07_RS19360	COG0629	single-stranded DNA binding
I3J07_RS19390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J07_RS19435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J07_RS19450	COG1486	melibiose metabolic process
I3J07_RS19455	COG0395	ABC-type sugar transport system, permease component
I3J07_RS19460	COG1175	transmembrane transport
I3J07_RS19480	COG0668	transmembrane transport
I3J07_RS19550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J07_RS19555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J07_RS19565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J07_RS19575	COG0588	phosphoglycerate mutase activity
I3J07_RS19580	COG1113	amino acid transport
I3J07_RS19590	COG1113	amino acid transport
I3J07_RS19605	COG4552	Acetyltransferase involved in intracellular survival and related
I3J07_RS19620	COG0475	glutathione-regulated potassium exporter activity
I3J07_RS19635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J07_RS19640	COG3594	Acyltransferase
I3J07_RS19660	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J07_RS19665	COG0740	serine-type endopeptidase activity
I3J07_RS19670	COG0740	serine-type endopeptidase activity
I3J07_RS19675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J07_RS19685	COG0525	valine-tRNA ligase activity
I3J07_RS19690	COG4585	Histidine kinase
I3J07_RS19695	COG0285	dihydrofolate synthase activity
I3J07_RS19705	COG0105	UTP biosynthetic process
I3J07_RS19710	COG1077	Cell shape determining protein MreB Mrl
I3J07_RS19730	COG0772	Belongs to the SEDS family
I3J07_RS19750	COG1530	ribonuclease E activity
I3J07_RS19760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J07_RS19765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J07_RS19770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J07_RS19775	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS19790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J07_RS19800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J07_RS19815	COG0501	Belongs to the peptidase M48B family
I3J07_RS19825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J07_RS19835	COG0799	negative regulation of ribosome biogenesis
I3J07_RS19840	COG0588	phosphoglycerate mutase activity
I3J07_RS19850	COG0495	leucyl-tRNA aminoacylation
I3J07_RS19860	COG1307	EDD domain protein, DegV family
I3J07_RS19895	COG0268	Binds directly to 16S ribosomal RNA
I3J07_RS19900	COG0481	GTPase activity
I3J07_RS19925	COG1420	regulation of RNA biosynthetic process
I3J07_RS19930	COG0484	heat shock protein binding
I3J07_RS19950	COG4946	Tricorn protease homolog
I3J07_RS19950	COG0793	Belongs to the peptidase S41A family
I3J07_RS19955	COG0537	adenosine 5'-monophosphoramidase activity
I3J07_RS19960	COG1234	tRNA 3'-trailer cleavage
I3J07_RS19965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J07_RS19970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J07_RS19980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J07_RS20020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J07_RS20035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J07_RS20050	COG1381	Involved in DNA repair and RecF pathway recombination
I3J07_RS20055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J07_RS20065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J07_RS20070	COG1121	(ABC) transporter
I3J07_RS20075	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J07_RS20075	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J07_RS20080	COG0423	glycine-tRNA ligase activity
I3J07_RS20120	COG0574	Belongs to the PEP-utilizing enzyme family
I3J07_RS20120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J07_RS20135	COG0531	amino acid
I3J07_RS20145	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS20150	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J07_RS20170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J07_RS20190	COG2949	membrane
I3J07_RS20195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J07_RS20205	COG0358	DNA primase activity
I3J07_RS20210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J07_RS20225	COG1070	Carbohydrate kinase
I3J07_RS20260	COG0842	Transport permease protein
I3J07_RS20260	COG1129	ABC transporter
I3J07_RS20320	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS20325	COG1136	(ABC) transporter
I3J07_RS20380	COG2130	NADP-dependent
I3J07_RS20415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J07_RS20420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J07_RS20425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J07_RS20450	COG0789	Transcriptional regulator
I3J07_RS20455	COG0667	Aldo Keto reductase
I3J07_RS20460	COG2197	response regulator
I3J07_RS20465	COG4585	Histidine kinase
I3J07_RS20485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J07_RS20490	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J07_RS20535	COG1358	cellular component organization or biogenesis
I3J07_RS20545	COG0586	Pfam SNARE associated Golgi protein
I3J07_RS20570	COG0582	viral genome integration into host DNA
I3J07_RS20680	COG4122	O-methyltransferase activity
I3J07_RS20690	COG2124	cytochrome p450
I3J07_RS20695	COG0183	Belongs to the thiolase family
I3J07_RS20710	COG3845	ABC transporter
I3J07_RS20745	COG1309	transcriptional regulator
I3J07_RS20750	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS20755	COG2226	methyltransferase
I3J07_RS20765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS20785	COG0183	Belongs to the thiolase family
I3J07_RS20800	COG2030	dehydratase
I3J07_RS20805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J07_RS20810	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS20825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J07_RS20845	COG0800	Aldolase
I3J07_RS20850	COG3022	response to hydroperoxide
I3J07_RS20865	COG0789	Transcriptional regulator
I3J07_RS20885	COG1349	DNA-binding transcription factor activity
I3J07_RS20890	COG1653	transport
I3J07_RS20900	COG0395	ABC-type sugar transport system, permease component
I3J07_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS20950	COG3540	Alkaline phosphatase
I3J07_RS20955	COG2814	Major facilitator Superfamily
I3J07_RS20970	COG1834	amidinotransferase
I3J07_RS20990	COG1120	ATPase activity
I3J07_RS20995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS21020	COG5398	heme oxygenase
I3J07_RS21055	COG1994	Peptidase M50
I3J07_RS21075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J07_RS21085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J07_RS21085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J07_RS21090	COG2132	Multicopper oxidase
I3J07_RS21125	COG0174	glutamine synthetase
I3J07_RS21140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J07_RS21155	COG1228	amidohydrolase
I3J07_RS21180	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J07_RS21185	COG0494	nUDIX hydrolase
I3J07_RS21200	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J07_RS21220	COG1609	Transcriptional regulator
I3J07_RS21225	COG0366	Alpha amylase catalytic
I3J07_RS21230	COG3833	ABC-type maltose transport systems, permease component
I3J07_RS21235	COG1175	transmembrane transport
I3J07_RS21265	COG2197	response regulator
I3J07_RS21305	COG0745	RESPONSE REGULATOR receiver
I3J07_RS21315	COG0673	inositol 2-dehydrogenase activity
I3J07_RS21340	COG0181	hydroxymethylbilane synthase activity
I3J07_RS21390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J07_RS21395	COG0321	lipoyl(octanoyl) transferase activity
I3J07_RS21410	COG1090	epimerase
I3J07_RS21440	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J07_RS21450	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J07_RS21455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J07_RS21460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J07_RS21465	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J07_RS21475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J07_RS21505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J07_RS21510	COG1132	(ABC) transporter
I3J07_RS21535	COG4585	Histidine kinase
I3J07_RS21540	COG2197	response regulator
I3J07_RS21545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J07_RS21555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J07_RS21575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J07_RS21585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J07_RS21590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J07_RS21600	COG1376	ErfK ybiS ycfS ynhG family protein
I3J07_RS21610	COG1845	cytochrome c oxidase, subunit III
I3J07_RS21615	COG2010	Cytochrome c
I3J07_RS21620	COG0723	plastoquinol--plastocyanin reductase activity
I3J07_RS21625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J07_RS21630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J07_RS21635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J07_RS21640	COG1929	Belongs to the glycerate kinase type-1 family
I3J07_RS21650	COG0745	RESPONSE REGULATOR receiver
I3J07_RS21655	COG2205	protein histidine kinase activity
I3J07_RS21705	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS21730	COG0003	Pfam Anion-transporting ATPase
I3J07_RS21740	COG1940	carbohydrate kinase activity
I3J07_RS21770	COG2197	response regulator
I3J07_RS21775	COG0205	6-phosphofructokinase activity
I3J07_RS21785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J07_RS21790	COG0243	molybdopterin cofactor binding
I3J07_RS21795	COG2193	ferroxidase activity
I3J07_RS21800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J07_RS21805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J07_RS21810	COG2815	serine threonine protein kinase
I3J07_RS21810	COG0515	serine threonine protein kinase
I3J07_RS21815	COG2022	thiamine diphosphate biosynthetic process
I3J07_RS21825	COG2022	thiamine diphosphate biosynthetic process
I3J07_RS21825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J07_RS21845	COG0352	thiamine-phosphate diphosphorylase activity
I3J07_RS21860	COG1233	COG1233 Phytoene dehydrogenase and related
I3J07_RS21870	COG1309	transcriptional regulator
I3J07_RS21875	COG1511	domain protein
I3J07_RS21880	COG1121	(ABC) transporter
I3J07_RS21910	COG0714	Associated with various cellular activities
I3J07_RS21920	COG0275	rRNA processing
I3J07_RS21930	COG0768	penicillin binding
I3J07_RS21935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J07_RS21940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J07_RS21945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J07_RS21950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J07_RS21960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J07_RS21965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J07_RS21975	COG1496	oxidoreductase activity
I3J07_RS21985	COG1799	cell septum assembly
I3J07_RS21995	COG3599	regulation of cell shape
I3J07_RS22000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J07_RS22015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J07_RS22065	COG0587	DNA-directed DNA polymerase activity
I3J07_RS22075	COG1432	Conserved Protein
I3J07_RS22095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J07_RS22115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J07_RS22120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J07_RS22125	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J07_RS22135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J07_RS22140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J07_RS22145	COG0251	oxidation-reduction process
I3J07_RS22150	COG0107	imidazoleglycerol-phosphate synthase activity
I3J07_RS22165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J07_RS22170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J07_RS22190	COG0134	indole-3-glycerol-phosphate synthase activity
I3J07_RS22200	COG0133	tryptophan synthase activity
I3J07_RS22205	COG0159	tryptophan synthase activity
I3J07_RS22215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J07_RS22220	COG2301	Belongs to the HpcH HpaI aldolase family
I3J07_RS22225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J07_RS22230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J07_RS22265	COG0069	glutamate synthase activity
I3J07_RS22265	COG0070	glutamate synthase
I3J07_RS22265	COG0067	glutamate synthase
I3J07_RS22290	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS22300	COG1309	transcriptional regulator
I3J07_RS22305	COG0183	Belongs to the thiolase family
I3J07_RS22335	COG1024	Enoyl-CoA hydratase
I3J07_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS22360	COG0366	Alpha amylase catalytic
I3J07_RS22360	COG1470	cell adhesion involved in biofilm formation
I3J07_RS22375	COG0287	Prephenate dehydrogenase
I3J07_RS22375	COG1605	Chorismate mutase
I3J07_RS22425	COG0411	ABC transporter
I3J07_RS22445	COG2050	protein possibly involved in aromatic compounds catabolism
I3J07_RS22475	COG1643	Atp-dependent helicase
I3J07_RS22480	COG2226	methyltransferase
I3J07_RS22480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J07_RS22480	COG0596	Alpha beta hydrolase
I3J07_RS22485	COG0539	negative regulation of cytoplasmic translation
I3J07_RS22495	COG0237	dephospho-CoA kinase activity
I3J07_RS22515	COG0330	HflC and HflK could
I3J07_RS22520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J07_RS22550	COG2313	pseudouridylate synthase activity
I3J07_RS22560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J07_RS22565	COG0584	glycerophosphoryl diester phosphodiesterase
I3J07_RS22575	COG0556	nucleotide-excision repair
I3J07_RS22595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J07_RS22605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J07_RS22610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J07_RS22610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J07_RS22635	COG0322	excinuclease ABC activity
I3J07_RS22640	COG1660	Displays ATPase and GTPase activities
I3J07_RS22645	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J07_RS22650	COG1481	regulation of sporulation
I3J07_RS22660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J07_RS22665	COG0126	phosphoglycerate kinase activity
I3J07_RS22670	COG0149	triose-phosphate isomerase activity
I3J07_RS22675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J07_RS22685	COG0166	Belongs to the GPI family
I3J07_RS22690	COG3402	PFAM membrane-flanked domain
I3J07_RS22700	COG0363	glucosamine-6-phosphate deaminase activity
I3J07_RS22715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J07_RS22725	COG0109	protoheme IX farnesyltransferase activity
I3J07_RS22755	COG1131	(ABC) transporter
I3J07_RS22770	COG0719	Fe-S assembly protein
I3J07_RS22780	COG0396	ATPase activity
I3J07_RS22785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J07_RS22790	COG0822	iron-sulfur transferase activity
I3J07_RS22795	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J07_RS22800	COG2171	N-acyltransferase activity
I3J07_RS22810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J07_RS22860	COG2205	protein histidine kinase activity
I3J07_RS22865	COG0745	RESPONSE REGULATOR receiver
I3J07_RS22880	COG1802	Transcriptional regulator
I3J07_RS22895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J07_RS22900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J07_RS22910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J07_RS22920	COG0768	penicillin binding
I3J07_RS22925	COG2197	response regulator
I3J07_RS22930	COG4585	Histidine kinase
I3J07_RS22935	COG1414	Transcriptional regulator
I3J07_RS22960	COG1902	pentaerythritol trinitrate reductase activity
I3J07_RS22965	COG5285	phytanoyl-CoA dioxygenase
I3J07_RS22970	COG1917	Cupin 2, conserved barrel domain protein
I3J07_RS22985	COG0134	indole-3-glycerol-phosphate synthase activity
I3J07_RS23015	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J07_RS23030	COG1492	cobalamin metabolic process
I3J07_RS23035	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J07_RS23050	COG0235	Class ii aldolase
I3J07_RS23065	COG0488	(ABC) transporter
I3J07_RS23075	COG1024	Enoyl-CoA hydratase
I3J07_RS23115	COG3387	PFAM Glycoside hydrolase 15-related
I3J07_RS23150	COG1404	Belongs to the peptidase S8 family
I3J07_RS23160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J07_RS23165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J07_RS23185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J07_RS23200	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS23205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J07_RS23210	COG2186	Transcriptional regulator
I3J07_RS23215	COG2807	transmembrane transport
I3J07_RS23230	COG3830	Belongs to the UPF0237 family
I3J07_RS23230	COG0560	Phosphoserine phosphatase
I3J07_RS23235	COG0842	Transport permease protein
I3J07_RS23235	COG1716	ATPase activity
I3J07_RS23235	COG1131	(ABC) transporter
I3J07_RS23245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J07_RS23255	COG4585	Histidine kinase
I3J07_RS23260	COG2197	response regulator
I3J07_RS23275	COG1119	ATPase activity
I3J07_RS23300	COG1881	PFAM PEBP family protein
I3J07_RS23310	COG2094	Belongs to the DNA glycosylase MPG family
I3J07_RS23345	COG0647	UMP catabolic process
I3J07_RS23350	COG1120	ATPase activity
I3J07_RS23370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J07_RS23375	COG0497	DNA recombination
I3J07_RS23380	COG0297	glycogen (starch) synthase activity
I3J07_RS23390	COG3387	PFAM Glycoside hydrolase 15-related
I3J07_RS23395	COG0504	CTP synthase activity
I3J07_RS23400	COG0494	nUDIX hydrolase
I3J07_RS23410	COG0686	Belongs to the AlaDH PNT family
I3J07_RS23425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J07_RS23430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J07_RS23435	COG1187	pseudouridine synthase activity
I3J07_RS23440	COG1056	cytidyltransferase-related domain
I3J07_RS23440	COG1051	belongs to the nudix hydrolase family
I3J07_RS23465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J07_RS23475	COG1160	GTP binding
I3J07_RS23495	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS23505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J07_RS23515	COG0671	phosphoesterase, PA-phosphatase related
I3J07_RS23520	COG0477	Major facilitator Superfamily
I3J07_RS23525	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS23530	COG1799	cell septum assembly
I3J07_RS23580	COG0641	radical SAM
I3J07_RS23595	COG3629	intracellular signal transduction
I3J07_RS23595	COG3903	Transcriptional regulator
I3J07_RS23600	COG0596	Alpha beta hydrolase
I3J07_RS23625	COG4565	transcriptional regulatory protein
I3J07_RS23650	COG1725	Transcriptional regulator
I3J07_RS23660	COG2755	lipolytic protein G-D-S-L family
I3J07_RS23670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J07_RS23675	COG2188	Transcriptional regulator
I3J07_RS23680	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J07_RS23685	COG2851	Citrate transporter
I3J07_RS23720	COG3876	Protein conserved in bacteria
I3J07_RS23735	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS23750	COG2149	membrane
I3J07_RS23770	COG3265	gluconokinase activity
I3J07_RS23775	COG2186	Transcriptional regulator
I3J07_RS23780	COG1113	amino acid transport
I3J07_RS23810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J07_RS23840	COG0667	Aldo Keto reductase
I3J07_RS23845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS23855	COG0598	Magnesium transport protein CorA
I3J07_RS23875	COG0215	cysteine-tRNA ligase activity
I3J07_RS23885	COG4948	Mandelate Racemase Muconate Lactonizing
I3J07_RS23890	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS23900	COG1129	ABC transporter
I3J07_RS23910	COG2186	Transcriptional regulator
I3J07_RS23915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J07_RS23920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J07_RS23925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J07_RS23930	COG1414	Transcriptional regulator
I3J07_RS23935	COG0646	methionine synthase
I3J07_RS23935	COG1410	methionine synthase
I3J07_RS23940	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS23955	COG2197	response regulator
I3J07_RS23965	COG0517	IMP dehydrogenase activity
I3J07_RS23965	COG1994	Peptidase M50
I3J07_RS23985	COG1222	aaa ATPase
I3J07_RS23990	COG4122	O-methyltransferase activity
I3J07_RS24005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J07_RS24010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J07_RS24015	COG1609	Transcriptional regulator
I3J07_RS24025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J07_RS24060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J07_RS24065	COG0805	protein transport
I3J07_RS24100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J07_RS24105	COG4175	Glycine betaine
I3J07_RS24105	COG0517	IMP dehydrogenase activity
I3J07_RS24125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J07_RS24130	COG1113	amino acid transport
I3J07_RS24135	COG2186	Transcriptional regulator
I3J07_RS24140	COG0174	glutamine synthetase
I3J07_RS24165	COG1404	Belongs to the peptidase S8 family
I3J07_RS24185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J07_RS24190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J07_RS24195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J07_RS24200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J07_RS24205	COG5002	protein histidine kinase activity
I3J07_RS24210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J07_RS24215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J07_RS24215	COG0072	phenylalanine-tRNA ligase activity
I3J07_RS24235	COG1649	PFAM Uncharacterised BCR, COG1649
I3J07_RS24245	COG0697	spore germination
I3J07_RS24255	COG2838	Isocitrate dehydrogenase
I3J07_RS24280	COG4585	Histidine kinase
I3J07_RS24285	COG2197	response regulator
I3J07_RS24290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J07_RS24295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J07_RS24300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J07_RS24305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J07_RS24310	COG1438	arginine binding
I3J07_RS24315	COG0137	argininosuccinate synthase activity
I3J07_RS24320	COG0165	Argininosuccinate lyase
I3J07_RS24330	COG0477	Major facilitator Superfamily
I3J07_RS24335	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS24335	COG0204	Acyl-transferase
I3J07_RS24340	COG0584	glycerophosphoryl diester phosphodiesterase
I3J07_RS24360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J07_RS24365	COG2011	ABC-type metal ion transport system permease component
I3J07_RS24370	COG1464	Belongs to the NlpA lipoprotein family
I3J07_RS24385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J07_RS24390	COG1648	precorrin-2 dehydrogenase activity
I3J07_RS24390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J07_RS24435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J07_RS24445	COG0456	acetyltransferase
I3J07_RS24495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J07_RS24500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J07_RS24505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J07_RS24525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J07_RS24530	COG1560	Kdo2-lipid A biosynthetic process
I3J07_RS24535	COG0438	transferase activity, transferring glycosyl groups
I3J07_RS24545	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J07_RS24550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J07_RS24555	COG0217	transcriptional regulatory protein
I3J07_RS24560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J07_RS24565	COG0632	four-way junction helicase activity
I3J07_RS24570	COG2255	four-way junction helicase activity
I3J07_RS24580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS24585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS24590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J07_RS24595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J07_RS24605	COG1196	nuclear chromosome segregation
I3J07_RS24610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J07_RS24620	COG0124	histidyl-tRNA synthetase
I3J07_RS24640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J07_RS24655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J07_RS24660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J07_RS24665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J07_RS24670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J07_RS24675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J07_RS24680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J07_RS24685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J07_RS24690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J07_RS24700	COG0006	proline dipeptidase activity
I3J07_RS24705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J07_RS24710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J07_RS24720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J07_RS24725	COG0540	Belongs to the ATCase OTCase family
I3J07_RS24730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J07_RS24740	COG0505	Belongs to the CarA family
I3J07_RS24745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J07_RS24750	COG0167	dihydroorotate dehydrogenase activity
I3J07_RS24755	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J07_RS24780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J07_RS24795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J07_RS24805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J07_RS24810	COG2390	Transcriptional regulator
I3J07_RS24840	COG1191	sigma factor activity
I3J07_RS24850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J07_RS24865	COG2233	PERMEase
I3J07_RS24875	COG0738	Major facilitator superfamily
I3J07_RS24880	COG1940	carbohydrate kinase activity
I3J07_RS24880	COG1846	Transcriptional regulator
I3J07_RS24895	COG3201	nicotinamide mononucleotide transporter
I3J07_RS24900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J07_RS24900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J07_RS24905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J07_RS24910	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J07_RS24915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J07_RS24955	COG1309	transcriptional regulator
I3J07_RS24960	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS24980	COG1216	Glycosyl transferase, family 2
I3J07_RS24995	COG2270	Major facilitator Superfamily
I3J07_RS25005	COG2364	Membrane
I3J07_RS25010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J07_RS25040	COG1984	allophanate hydrolase subunit 2
I3J07_RS25045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J07_RS25050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J07_RS25055	COG2814	Major facilitator Superfamily
I3J07_RS25085	COG5002	protein histidine kinase activity
I3J07_RS25090	COG2018	Roadblock/LC7 domain
I3J07_RS25105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J07_RS25110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J07_RS25115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J07_RS25135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J07_RS25145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J07_RS25175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J07_RS25195	COG1716	ATPase activity
I3J07_RS25215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J07_RS25225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J07_RS25225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J07_RS25290	COG0697	spore germination
I3J07_RS25345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J07_RS25360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J07_RS25370	COG2813	Specifically methylates the guanine in position
I3J07_RS25385	COG1968	undecaprenyl-diphosphatase activity
I3J07_RS25400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J07_RS25425	COG2124	cytochrome p450
I3J07_RS25455	COG0110	maltose O-acetyltransferase activity
I3J07_RS25460	COG1832	CoA-binding protein
I3J07_RS25465	COG1739	Uncharacterized protein family UPF0029
I3J07_RS25475	COG0666	response to abiotic stimulus
I3J07_RS25480	COG0420	3'-5' exonuclease activity
I3J07_RS25485	COG0419	ATPase involved in DNA repair
I3J07_RS25485	COG0419	ATPase involved in DNA repair
I3J07_RS25490	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS25520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J07_RS25535	COG2188	Transcriptional regulator
I3J07_RS25540	COG1940	carbohydrate kinase activity
I3J07_RS25550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J07_RS25585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J07_RS25590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS25595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J07_RS25615	COG0740	serine-type endopeptidase activity
I3J07_RS25625	COG0831	urea catabolic process
I3J07_RS25630	COG0832	Belongs to the urease beta subunit family
I3J07_RS25635	COG0804	urea catabolic process
I3J07_RS25645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J07_RS25650	COG0829	nickel cation binding
I3J07_RS25660	COG0204	Acyl-transferase
I3J07_RS25675	COG0142	geranyltranstransferase activity
I3J07_RS25680	COG0142	geranyltranstransferase activity
I3J07_RS25700	COG0205	6-phosphofructokinase activity
I3J07_RS25705	COG3442	glutamine amidotransferase
I3J07_RS25715	COG0242	peptide deformylase activity
I3J07_RS25725	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS25750	COG0386	Belongs to the glutathione peroxidase family
I3J07_RS25755	COG1946	Acyl-CoA thioesterase
I3J07_RS25775	COG1132	(ABC) transporter
I3J07_RS25775	COG2375	cellular response to nickel ion
I3J07_RS25780	COG1132	(ABC) transporter
I3J07_RS25790	COG2409	Drug exporters of the RND superfamily
I3J07_RS25805	COG2124	cytochrome p450
I3J07_RS25815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J07_RS25825	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS25840	COG0477	Major facilitator Superfamily
I3J07_RS25870	COG4585	Histidine kinase
I3J07_RS25875	COG2197	response regulator
I3J07_RS25895	COG2409	Drug exporters of the RND superfamily
I3J07_RS25905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J07_RS25905	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J07_RS25910	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J07_RS25965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J07_RS25970	COG0604	alcohol dehydrogenase
I3J07_RS25970	COG3321	synthase
I3J07_RS25985	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS26005	COG1132	(ABC) transporter
I3J07_RS26010	COG2072	flavoprotein involved in K transport
I3J07_RS26070	COG0443	Heat shock 70 kDa protein
I3J07_RS26085	COG1309	transcriptional regulator
I3J07_RS26095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS26100	COG1902	pentaerythritol trinitrate reductase activity
I3J07_RS26155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J07_RS26200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS26205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS26210	COG1120	ATPase activity
I3J07_RS26220	COG1132	(ABC) transporter
I3J07_RS26245	COG4607	ABC-type enterochelin transport system periplasmic component
I3J07_RS26250	COG0464	growth
I3J07_RS26255	COG1404	Belongs to the peptidase S8 family
I3J07_RS26260	COG1674	ftsk spoiiie
I3J07_RS26325	COG1278	Cold shock
I3J07_RS26340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J07_RS26350	COG0577	efflux transmembrane transporter activity
I3J07_RS26350	COG1136	(ABC) transporter
I3J07_RS26355	COG1136	(ABC) transporter
I3J07_RS26355	COG0577	efflux transmembrane transporter activity
I3J07_RS26370	COG0745	RESPONSE REGULATOR receiver
I3J07_RS26375	COG2205	protein histidine kinase activity
I3J07_RS26410	COG0463	Glycosyl transferase, family 2
I3J07_RS26415	COG0326	Molecular chaperone. Has ATPase activity
I3J07_RS26455	COG0309	Hydrogenase expression formation protein (HypE)
I3J07_RS26465	COG0298	carbon dioxide binding
I3J07_RS26475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J07_RS26480	COG0375	protein maturation
I3J07_RS26560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J07_RS26595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J07_RS26610	COG2706	6-phosphogluconolactonase activity
I3J07_RS26625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J07_RS26650	COG1309	transcriptional regulator
I3J07_RS26655	COG0671	phosphoesterase, PA-phosphatase related
I3J07_RS26680	COG0584	glycerophosphoryl diester phosphodiesterase
I3J07_RS26700	COG0204	Acyl-transferase
I3J07_RS26710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J07_RS26730	COG3345	alpha-galactosidase
I3J07_RS26740	COG1175	transmembrane transport
I3J07_RS26745	COG0395	ABC-type sugar transport system, permease component
I3J07_RS26765	COG0644	oxidoreductase
I3J07_RS26780	COG1940	carbohydrate kinase activity
I3J07_RS26800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J07_RS26810	COG1349	DNA-binding transcription factor activity
I3J07_RS26830	COG1215	transferase activity, transferring glycosyl groups
I3J07_RS26835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J07_RS26920	COG1486	melibiose metabolic process
I3J07_RS26965	COG1012	belongs to the aldehyde dehydrogenase family
I3J07_RS26970	COG0363	glucosamine-6-phosphate deaminase activity
I3J07_RS26995	COG1461	Dihydroxyacetone kinase
I3J07_RS27000	COG2376	Dihydroxyacetone kinase
I3J07_RS27035	COG1131	(ABC) transporter
I3J07_RS27090	COG1846	Transcriptional regulator
I3J07_RS27125	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J07_RS27130	COG1959	2 iron, 2 sulfur cluster binding
I3J07_RS27135	COG1017	nitric oxide dioxygenase activity
I3J07_RS27135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J07_RS27155	COG3511	phospholipase C
I3J07_RS27165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J07_RS27165	COG1796	DNA polymerase
I3J07_RS27175	COG2814	Major facilitator Superfamily
I3J07_RS27215	COG1960	acyl-CoA dehydrogenase activity
I3J07_RS27225	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J07_RS27240	COG1335	isochorismatase
I3J07_RS27245	COG0010	Belongs to the arginase family
I3J07_RS27250	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J07_RS27295	COG0701	Predicted permease
I3J07_RS27305	COG0515	serine threonine protein kinase
I3J07_RS27305	COG2815	serine threonine protein kinase
I3J07_RS27315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J07_RS27320	COG2070	2-Nitropropane dioxygenase
I3J07_RS27330	COG0387	Pfam Sodium calcium exchanger
I3J07_RS27335	COG2267	carboxylic ester hydrolase activity
I3J07_RS27340	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS27405	COG1132	(ABC) transporter
I3J07_RS27405	COG2375	cellular response to nickel ion
I3J07_RS27420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS27420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS27430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J07_RS27435	COG0765	amino acid transport
I3J07_RS27440	COG1126	abc transporter atp-binding protein
I3J07_RS27460	COG1957	nucleoside hydrolase
I3J07_RS27470	COG2318	DinB family
I3J07_RS27490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS27495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS27540	COG0501	Belongs to the peptidase M48B family
I3J07_RS27580	COG4412	M6 family metalloprotease domain protein
I3J07_RS27580	COG1404	Belongs to the peptidase S8 family
I3J07_RS27580	COG4412	M6 family metalloprotease domain protein
I3J07_RS27580	COG1404	Belongs to the peptidase S8 family
I3J07_RS27635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J07_RS27650	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS27685	COG0288	reversible hydration of carbon dioxide
I3J07_RS27695	COG0702	epimerase
I3J07_RS27705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J07_RS27720	COG2226	methyltransferase
I3J07_RS27730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J07_RS27735	COG1937	Protein conserved in bacteria
I3J07_RS27765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J07_RS27830	COG0142	geranyltranstransferase activity
I3J07_RS27840	COG1132	(ABC) transporter
I3J07_RS27850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J07_RS28050	COG0604	alcohol dehydrogenase
I3J07_RS28050	COG3321	synthase
I3J07_RS28060	COG3321	synthase
I3J07_RS28060	COG0604	alcohol dehydrogenase
I3J07_RS28220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J07_RS28265	COG2161	toxin-antitoxin pair type II binding
I3J07_RS28310	COG3547	Transposase (IS116 IS110 IS902 family)
I3J07_RS28320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J07_RS28325	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS28395	COG2197	response regulator
I3J07_RS28425	COG2814	Major facilitator Superfamily
I3J07_RS28430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J07_RS28445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J07_RS28485	COG0604	alcohol dehydrogenase
I3J07_RS28485	COG3321	synthase
I3J07_RS28505	COG2814	Major facilitator Superfamily
I3J07_RS28525	COG0076	glutamate decarboxylase activity
I3J07_RS28560	COG0531	amino acid
I3J07_RS28570	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J07_RS28585	COG2304	oxidoreductase activity
I3J07_RS28625	COG2197	response regulator
I3J07_RS28635	COG1222	aaa ATPase
I3J07_RS28645	COG3903	Transcriptional regulator
I3J07_RS28645	COG3629	intracellular signal transduction
I3J07_RS28720	COG2124	cytochrome p450
I3J07_RS28750	COG0789	Transcriptional regulator
I3J07_RS28755	COG0436	Aminotransferase
I3J07_RS28765	COG1695	Transcriptional regulator
I3J07_RS28770	COG2124	cytochrome p450
I3J07_RS28775	COG2124	cytochrome p450
I3J07_RS28780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J07_RS28785	COG0346	lactoylglutathione lyase activity
I3J07_RS28790	COG0640	Transcriptional regulator
I3J07_RS28800	COG2226	methyltransferase
I3J07_RS28810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J07_RS28860	COG0577	efflux transmembrane transporter activity
I3J07_RS28860	COG1136	(ABC) transporter
I3J07_RS28865	COG1136	(ABC) transporter
I3J07_RS28865	COG0577	efflux transmembrane transporter activity
I3J07_RS28880	COG0745	RESPONSE REGULATOR receiver
I3J07_RS28885	COG2205	protein histidine kinase activity
I3J07_RS28915	COG4948	Mandelate Racemase Muconate Lactonizing
I3J07_RS28950	COG2124	cytochrome p450
I3J07_RS28960	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS29070	COG2124	cytochrome p450
I3J07_RS29095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J07_RS29130	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J07_RS29130	COG2319	Wd-40 repeat
I3J07_RS29135	COG1335	isochorismatase
I3J07_RS29175	COG3409	Peptidoglycan-binding domain 1 protein
I3J07_RS29180	COG3973	AAA domain
I3J07_RS29210	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J07_RS29215	COG5183	chlorophyll binding
I3J07_RS29215	COG2133	pyrroloquinoline quinone binding
I3J07_RS29240	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS29250	COG2201	protein-glutamate methylesterase activity
I3J07_RS29265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS29270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J07_RS29275	COG0010	Belongs to the arginase family
I3J07_RS29280	COG0367	asparagine synthase
I3J07_RS29300	COG0436	Aminotransferase
I3J07_RS29305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J07_RS29315	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J07_RS29330	COG0583	DNA-binding transcription factor activity
I3J07_RS29375	COG2111	Na H antiporter
I3J07_RS29375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J07_RS29380	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J07_RS29385	COG0651	ATP synthesis coupled electron transport
I3J07_RS29400	COG1320	monovalent cation:proton antiporter activity
I3J07_RS29555	COG3959	Transketolase, thiamine diphosphate binding domain
I3J07_RS29560	COG3958	Transketolase
I3J07_RS29595	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J07_RS29600	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS29605	COG0277	FAD linked oxidase domain protein
I3J07_RS29610	COG1070	Carbohydrate kinase
I3J07_RS29655	COG2124	cytochrome p450
I3J07_RS29665	COG1011	Hydrolase
I3J07_RS29705	COG0789	Transcriptional regulator
I3J07_RS29715	COG3397	chitin binding
I3J07_RS29745	COG1132	(ABC) transporter
I3J07_RS29805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J07_RS29810	COG2124	cytochrome p450
I3J07_RS29825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J07_RS29845	COG3409	Peptidoglycan-binding domain 1 protein
I3J07_RS29845	COG3757	hydrolase, family 25
I3J07_RS29880	COG0488	(ABC) transporter
I3J07_RS29910	COG0698	ribose 5-phosphate isomerase
I3J07_RS29945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J07_RS29955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J07_RS29970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J07_RS29980	COG2267	carboxylic ester hydrolase activity
I3J07_RS30060	COG0477	Major facilitator Superfamily
I3J07_RS30105	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS30140	COG2226	methyltransferase
I3J07_RS30155	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J07_RS30170	COG3409	Peptidoglycan-binding domain 1 protein
I3J07_RS30210	COG0494	nUDIX hydrolase
I3J07_RS30225	COG3903	Transcriptional regulator
I3J07_RS30225	COG3629	intracellular signal transduction
I3J07_RS30250	COG1725	Transcriptional regulator
I3J07_RS30255	COG1131	(ABC) transporter
I3J07_RS30265	COG1309	transcriptional regulator
I3J07_RS30290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J07_RS30340	COG2318	DinB family
I3J07_RS30435	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J07_RS30435	COG2319	Wd-40 repeat
I3J07_RS30465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J07_RS30470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J07_RS30485	COG0431	NADPH-dependent FMN reductase
I3J07_RS30495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS30500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS30505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J07_RS30540	COG0640	Transcriptional regulator
I3J07_RS30560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J07_RS30570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J07_RS30575	COG0301	tRNA thio-modification
I3J07_RS30605	COG1024	Enoyl-CoA hydratase
I3J07_RS30650	COG0110	maltose O-acetyltransferase activity
I3J07_RS30690	COG0477	Major facilitator Superfamily
I3J07_RS30730	COG0546	phosphoglycolate phosphatase activity
I3J07_RS30745	COG0363	glucosamine-6-phosphate deaminase activity
I3J07_RS30750	COG1940	carbohydrate kinase activity
I3J07_RS30775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J07_RS30785	COG4552	Acetyltransferase involved in intracellular survival and related
I3J07_RS30795	COG2816	NAD+ diphosphatase activity
I3J07_RS30805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J07_RS30810	COG1228	amidohydrolase
I3J07_RS30865	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J07_RS30870	COG1732	Glycine betaine
I3J07_RS30875	COG1174	glycine betaine transport
I3J07_RS30880	COG1125	glycine betaine transport
I3J07_RS30880	COG0517	IMP dehydrogenase activity
I3J07_RS30895	COG0076	glutamate decarboxylase activity
I3J07_RS30915	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J07_RS30920	COG1121	(ABC) transporter
I3J07_RS30965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J07_RS31215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J07_RS31225	COG1132	(ABC) transporter
I3J07_RS31235	COG0142	geranyltranstransferase activity
I3J07_RS31300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J07_RS31330	COG1937	Protein conserved in bacteria
I3J07_RS31335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J07_RS31345	COG2226	methyltransferase
I3J07_RS31360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J07_RS31370	COG0702	epimerase
I3J07_RS31380	COG0288	reversible hydration of carbon dioxide
I3J07_RS31415	COG1028	Short-chain dehydrogenase reductase Sdr
I3J07_RS31430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J07_RS31485	COG1404	Belongs to the peptidase S8 family
I3J07_RS31485	COG4412	M6 family metalloprotease domain protein
I3J07_RS31485	COG1404	Belongs to the peptidase S8 family
I3J07_RS31485	COG4412	M6 family metalloprotease domain protein
I3J07_RS31525	COG0501	Belongs to the peptidase M48B family
I3J07_RS31570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS31575	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J07_RS31595	COG2318	DinB family
I3J07_RS31605	COG1957	nucleoside hydrolase
I3J07_RS31625	COG1126	abc transporter atp-binding protein
I3J07_RS31630	COG0765	amino acid transport
I3J07_RS31635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J07_RS31645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS31645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J07_RS31660	COG2375	cellular response to nickel ion
I3J07_RS31660	COG1132	(ABC) transporter
I3J07_RS31725	COG0318	PFAM AMP-dependent synthetase and ligase
I3J07_RS31730	COG2267	carboxylic ester hydrolase activity
I3J07_RS31735	COG0387	Pfam Sodium calcium exchanger
I3J07_RS31745	COG2070	2-Nitropropane dioxygenase
I3J07_RS31750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J07_RS31760	COG0515	serine threonine protein kinase
I3J07_RS31760	COG2815	serine threonine protein kinase
I3J07_RS31770	COG0701	Predicted permease