locus-tag	class	description
I3J08_RS00020	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J08_RS00230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J08_RS00240	COG1132	(ABC) transporter
I3J08_RS00250	COG0142	geranyltranstransferase activity
I3J08_RS00345	COG1937	Protein conserved in bacteria
I3J08_RS00350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J08_RS00360	COG2226	methyltransferase
I3J08_RS00375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J08_RS00385	COG0702	epimerase
I3J08_RS00395	COG0288	reversible hydration of carbon dioxide
I3J08_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS00445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J08_RS00500	COG4412	M6 family metalloprotease domain protein
I3J08_RS00500	COG1404	Belongs to the peptidase S8 family
I3J08_RS00500	COG1404	Belongs to the peptidase S8 family
I3J08_RS00500	COG4412	M6 family metalloprotease domain protein
I3J08_RS00540	COG0501	Belongs to the peptidase M48B family
I3J08_RS00585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS00590	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS00610	COG2318	DinB family
I3J08_RS00620	COG1957	nucleoside hydrolase
I3J08_RS00640	COG1126	abc transporter atp-binding protein
I3J08_RS00645	COG0765	amino acid transport
I3J08_RS00650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J08_RS00660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS00660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS00675	COG1132	(ABC) transporter
I3J08_RS00675	COG2375	cellular response to nickel ion
I3J08_RS00740	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS00745	COG2267	carboxylic ester hydrolase activity
I3J08_RS00750	COG0387	Pfam Sodium calcium exchanger
I3J08_RS00760	COG2070	2-Nitropropane dioxygenase
I3J08_RS00765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J08_RS00775	COG0515	serine threonine protein kinase
I3J08_RS00775	COG2815	serine threonine protein kinase
I3J08_RS00785	COG0701	Predicted permease
I3J08_RS00835	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J08_RS00840	COG0010	Belongs to the arginase family
I3J08_RS00845	COG1335	isochorismatase
I3J08_RS00860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J08_RS00870	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS00910	COG2814	Major facilitator Superfamily
I3J08_RS00920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J08_RS00920	COG1796	DNA polymerase
I3J08_RS00930	COG3511	phospholipase C
I3J08_RS00950	COG1017	nitric oxide dioxygenase activity
I3J08_RS00950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J08_RS00955	COG1959	2 iron, 2 sulfur cluster binding
I3J08_RS00960	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J08_RS00995	COG1846	Transcriptional regulator
I3J08_RS01050	COG1131	(ABC) transporter
I3J08_RS01085	COG2376	Dihydroxyacetone kinase
I3J08_RS01090	COG1461	Dihydroxyacetone kinase
I3J08_RS01115	COG0363	glucosamine-6-phosphate deaminase activity
I3J08_RS01120	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS01165	COG1486	melibiose metabolic process
I3J08_RS01250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J08_RS01255	COG1215	transferase activity, transferring glycosyl groups
I3J08_RS01275	COG1349	DNA-binding transcription factor activity
I3J08_RS01285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J08_RS01305	COG1940	carbohydrate kinase activity
I3J08_RS01320	COG0644	oxidoreductase
I3J08_RS01340	COG0395	ABC-type sugar transport system, permease component
I3J08_RS01345	COG1175	transmembrane transport
I3J08_RS01355	COG3345	alpha-galactosidase
I3J08_RS01375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J08_RS01385	COG0204	Acyl-transferase
I3J08_RS01405	COG0584	glycerophosphoryl diester phosphodiesterase
I3J08_RS01430	COG0671	phosphoesterase, PA-phosphatase related
I3J08_RS01435	COG1309	transcriptional regulator
I3J08_RS01460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J08_RS01475	COG2706	6-phosphogluconolactonase activity
I3J08_RS01490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J08_RS01525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J08_RS01605	COG0375	protein maturation
I3J08_RS01610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J08_RS01620	COG0298	carbon dioxide binding
I3J08_RS01630	COG0309	Hydrogenase expression formation protein (HypE)
I3J08_RS01670	COG0326	Molecular chaperone. Has ATPase activity
I3J08_RS01675	COG0463	Glycosyl transferase, family 2
I3J08_RS01710	COG2205	protein histidine kinase activity
I3J08_RS01715	COG0745	RESPONSE REGULATOR receiver
I3J08_RS01730	COG0577	efflux transmembrane transporter activity
I3J08_RS01730	COG1136	(ABC) transporter
I3J08_RS01735	COG0577	efflux transmembrane transporter activity
I3J08_RS01735	COG1136	(ABC) transporter
I3J08_RS01745	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J08_RS01760	COG1278	Cold shock
I3J08_RS01825	COG1674	ftsk spoiiie
I3J08_RS01830	COG1404	Belongs to the peptidase S8 family
I3J08_RS01835	COG0464	growth
I3J08_RS01840	COG4607	ABC-type enterochelin transport system periplasmic component
I3J08_RS01865	COG1132	(ABC) transporter
I3J08_RS01875	COG1120	ATPase activity
I3J08_RS01880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS01930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J08_RS01985	COG1902	pentaerythritol trinitrate reductase activity
I3J08_RS01990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS02000	COG1309	transcriptional regulator
I3J08_RS02015	COG0443	Heat shock 70 kDa protein
I3J08_RS02075	COG2072	flavoprotein involved in K transport
I3J08_RS02080	COG1132	(ABC) transporter
I3J08_RS02100	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS02115	COG0604	alcohol dehydrogenase
I3J08_RS02115	COG3321	synthase
I3J08_RS02120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J08_RS02175	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J08_RS02180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J08_RS02180	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J08_RS02190	COG2409	Drug exporters of the RND superfamily
I3J08_RS02210	COG2197	response regulator
I3J08_RS02215	COG4585	Histidine kinase
I3J08_RS02245	COG0477	Major facilitator Superfamily
I3J08_RS02260	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS02270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J08_RS02280	COG2124	cytochrome p450
I3J08_RS02295	COG2409	Drug exporters of the RND superfamily
I3J08_RS02305	COG1132	(ABC) transporter
I3J08_RS02310	COG2375	cellular response to nickel ion
I3J08_RS02310	COG1132	(ABC) transporter
I3J08_RS02330	COG1946	Acyl-CoA thioesterase
I3J08_RS02335	COG0386	Belongs to the glutathione peroxidase family
I3J08_RS02360	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS02370	COG0242	peptide deformylase activity
I3J08_RS02380	COG3442	glutamine amidotransferase
I3J08_RS02385	COG0205	6-phosphofructokinase activity
I3J08_RS02405	COG0142	geranyltranstransferase activity
I3J08_RS02410	COG0142	geranyltranstransferase activity
I3J08_RS02425	COG0204	Acyl-transferase
I3J08_RS02435	COG0829	nickel cation binding
I3J08_RS02440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J08_RS02450	COG0804	urea catabolic process
I3J08_RS02455	COG0832	Belongs to the urease beta subunit family
I3J08_RS02460	COG0831	urea catabolic process
I3J08_RS02470	COG0740	serine-type endopeptidase activity
I3J08_RS02490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J08_RS02495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS02500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J08_RS02535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J08_RS02545	COG1940	carbohydrate kinase activity
I3J08_RS02550	COG2188	Transcriptional regulator
I3J08_RS02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J08_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS02600	COG0419	ATPase involved in DNA repair
I3J08_RS02600	COG0419	ATPase involved in DNA repair
I3J08_RS02605	COG0420	3'-5' exonuclease activity
I3J08_RS02610	COG0666	response to abiotic stimulus
I3J08_RS02620	COG1739	Uncharacterized protein family UPF0029
I3J08_RS02625	COG1832	CoA-binding protein
I3J08_RS02630	COG0110	maltose O-acetyltransferase activity
I3J08_RS02660	COG2124	cytochrome p450
I3J08_RS02685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J08_RS02700	COG1968	undecaprenyl-diphosphatase activity
I3J08_RS02715	COG2813	Specifically methylates the guanine in position
I3J08_RS02725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J08_RS02740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J08_RS02795	COG0697	spore germination
I3J08_RS02860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J08_RS02860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J08_RS02870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J08_RS02890	COG1716	ATPase activity
I3J08_RS02910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J08_RS02940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J08_RS02950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J08_RS02970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J08_RS02975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J08_RS02980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J08_RS02995	COG2018	Roadblock/LC7 domain
I3J08_RS03000	COG5002	protein histidine kinase activity
I3J08_RS03030	COG2814	Major facilitator Superfamily
I3J08_RS03035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J08_RS03040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J08_RS03045	COG1984	allophanate hydrolase subunit 2
I3J08_RS03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J08_RS03080	COG2364	Membrane
I3J08_RS03090	COG2270	Major facilitator Superfamily
I3J08_RS03105	COG1216	Glycosyl transferase, family 2
I3J08_RS03125	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS03130	COG1309	transcriptional regulator
I3J08_RS03170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J08_RS03175	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J08_RS03180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J08_RS03185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J08_RS03185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J08_RS03190	COG3201	nicotinamide mononucleotide transporter
I3J08_RS03205	COG1940	carbohydrate kinase activity
I3J08_RS03205	COG1846	Transcriptional regulator
I3J08_RS03210	COG0738	Major facilitator superfamily
I3J08_RS03220	COG2233	PERMEase
I3J08_RS03235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J08_RS03245	COG1191	sigma factor activity
I3J08_RS03275	COG2390	Transcriptional regulator
I3J08_RS03280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J08_RS03290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J08_RS03305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J08_RS03330	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J08_RS03335	COG0167	dihydroorotate dehydrogenase activity
I3J08_RS03340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J08_RS03345	COG0505	Belongs to the CarA family
I3J08_RS03355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J08_RS03360	COG0540	Belongs to the ATCase OTCase family
I3J08_RS03365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J08_RS03375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J08_RS03380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J08_RS03385	COG0006	proline dipeptidase activity
I3J08_RS03395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J08_RS03400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J08_RS03405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J08_RS03410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J08_RS03415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J08_RS03420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J08_RS03425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J08_RS03430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J08_RS03445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J08_RS03465	COG0124	histidyl-tRNA synthetase
I3J08_RS03475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J08_RS03480	COG1196	nuclear chromosome segregation
I3J08_RS03490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J08_RS03495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J08_RS03500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS03505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS03515	COG2255	four-way junction helicase activity
I3J08_RS03520	COG0632	four-way junction helicase activity
I3J08_RS03525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J08_RS03530	COG0217	transcriptional regulatory protein
I3J08_RS03535	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J08_RS03540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J08_RS03550	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS03555	COG1560	Kdo2-lipid A biosynthetic process
I3J08_RS03560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J08_RS03580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J08_RS03585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J08_RS03590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J08_RS03640	COG0456	acetyltransferase
I3J08_RS03650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J08_RS03695	COG1648	precorrin-2 dehydrogenase activity
I3J08_RS03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J08_RS03700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J08_RS03715	COG1464	Belongs to the NlpA lipoprotein family
I3J08_RS03720	COG2011	ABC-type metal ion transport system permease component
I3J08_RS03725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J08_RS03745	COG0584	glycerophosphoryl diester phosphodiesterase
I3J08_RS03750	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS03750	COG0204	Acyl-transferase
I3J08_RS03755	COG0477	Major facilitator Superfamily
I3J08_RS03765	COG0165	Argininosuccinate lyase
I3J08_RS03770	COG0137	argininosuccinate synthase activity
I3J08_RS03775	COG1438	arginine binding
I3J08_RS03780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J08_RS03785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J08_RS03790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J08_RS03795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J08_RS03800	COG2197	response regulator
I3J08_RS03805	COG4585	Histidine kinase
I3J08_RS03830	COG2838	Isocitrate dehydrogenase
I3J08_RS03840	COG0697	spore germination
I3J08_RS03850	COG1649	PFAM Uncharacterised BCR, COG1649
I3J08_RS03870	COG0072	phenylalanine-tRNA ligase activity
I3J08_RS03870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J08_RS03875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J08_RS03880	COG5002	protein histidine kinase activity
I3J08_RS03885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J08_RS03890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J08_RS03895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J08_RS03900	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J08_RS03920	COG1404	Belongs to the peptidase S8 family
I3J08_RS03945	COG0174	glutamine synthetase
I3J08_RS03950	COG2186	Transcriptional regulator
I3J08_RS03955	COG1113	amino acid transport
I3J08_RS03960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J08_RS03980	COG4175	Glycine betaine
I3J08_RS03980	COG0517	IMP dehydrogenase activity
I3J08_RS03985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J08_RS04020	COG0805	protein transport
I3J08_RS04025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J08_RS04060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J08_RS04070	COG1609	Transcriptional regulator
I3J08_RS04075	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J08_RS04080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J08_RS04095	COG4122	O-methyltransferase activity
I3J08_RS04100	COG1222	aaa ATPase
I3J08_RS04120	COG0517	IMP dehydrogenase activity
I3J08_RS04120	COG1994	Peptidase M50
I3J08_RS04130	COG2197	response regulator
I3J08_RS04145	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS04150	COG0646	methionine synthase
I3J08_RS04150	COG1410	methionine synthase
I3J08_RS04155	COG1414	Transcriptional regulator
I3J08_RS04160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J08_RS04165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J08_RS04170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J08_RS04175	COG2186	Transcriptional regulator
I3J08_RS04185	COG1129	ABC transporter
I3J08_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS04200	COG4948	Mandelate Racemase Muconate Lactonizing
I3J08_RS04210	COG0215	cysteine-tRNA ligase activity
I3J08_RS04230	COG0598	Magnesium transport protein CorA
I3J08_RS04240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS04245	COG0667	Aldo Keto reductase
I3J08_RS04275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J08_RS04305	COG1113	amino acid transport
I3J08_RS04310	COG2186	Transcriptional regulator
I3J08_RS04315	COG3265	gluconokinase activity
I3J08_RS04335	COG2149	membrane
I3J08_RS04350	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS04365	COG3876	Protein conserved in bacteria
I3J08_RS04400	COG2851	Citrate transporter
I3J08_RS04405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J08_RS04410	COG2188	Transcriptional regulator
I3J08_RS04415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J08_RS04425	COG2755	lipolytic protein G-D-S-L family
I3J08_RS04435	COG1725	Transcriptional regulator
I3J08_RS04460	COG4565	transcriptional regulatory protein
I3J08_RS04485	COG0596	Alpha beta hydrolase
I3J08_RS04490	COG3629	intracellular signal transduction
I3J08_RS04490	COG3903	Transcriptional regulator
I3J08_RS04505	COG0641	radical SAM
I3J08_RS04555	COG1799	cell septum assembly
I3J08_RS04560	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS04565	COG0477	Major facilitator Superfamily
I3J08_RS04570	COG0671	phosphoesterase, PA-phosphatase related
I3J08_RS04580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J08_RS04590	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS04610	COG1160	GTP binding
I3J08_RS04620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J08_RS04645	COG1051	belongs to the nudix hydrolase family
I3J08_RS04645	COG1056	cytidyltransferase-related domain
I3J08_RS04650	COG1187	pseudouridine synthase activity
I3J08_RS04655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J08_RS04660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J08_RS04675	COG0686	Belongs to the AlaDH PNT family
I3J08_RS04685	COG0494	nUDIX hydrolase
I3J08_RS04690	COG0504	CTP synthase activity
I3J08_RS04695	COG3387	PFAM Glycoside hydrolase 15-related
I3J08_RS04705	COG0297	glycogen (starch) synthase activity
I3J08_RS04710	COG0497	DNA recombination
I3J08_RS04715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J08_RS04735	COG1120	ATPase activity
I3J08_RS04740	COG0647	UMP catabolic process
I3J08_RS04775	COG2094	Belongs to the DNA glycosylase MPG family
I3J08_RS04785	COG1881	PFAM PEBP family protein
I3J08_RS04810	COG1119	ATPase activity
I3J08_RS04825	COG2197	response regulator
I3J08_RS04830	COG4585	Histidine kinase
I3J08_RS04840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J08_RS04850	COG1716	ATPase activity
I3J08_RS04850	COG1131	(ABC) transporter
I3J08_RS04850	COG0842	Transport permease protein
I3J08_RS04855	COG0560	Phosphoserine phosphatase
I3J08_RS04855	COG3830	Belongs to the UPF0237 family
I3J08_RS04870	COG2807	transmembrane transport
I3J08_RS04875	COG2186	Transcriptional regulator
I3J08_RS04880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J08_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS04900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J08_RS04920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J08_RS04925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J08_RS04935	COG1404	Belongs to the peptidase S8 family
I3J08_RS04970	COG3387	PFAM Glycoside hydrolase 15-related
I3J08_RS05010	COG1024	Enoyl-CoA hydratase
I3J08_RS05020	COG0488	(ABC) transporter
I3J08_RS05035	COG0235	Class ii aldolase
I3J08_RS05050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J08_RS05055	COG1492	cobalamin metabolic process
I3J08_RS05070	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J08_RS05100	COG0134	indole-3-glycerol-phosphate synthase activity
I3J08_RS05115	COG1917	Cupin 2, conserved barrel domain protein
I3J08_RS05120	COG5285	phytanoyl-CoA dioxygenase
I3J08_RS05125	COG1902	pentaerythritol trinitrate reductase activity
I3J08_RS05150	COG1414	Transcriptional regulator
I3J08_RS05155	COG4585	Histidine kinase
I3J08_RS05160	COG2197	response regulator
I3J08_RS05165	COG0768	penicillin binding
I3J08_RS05175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J08_RS05185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J08_RS05190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J08_RS05205	COG1802	Transcriptional regulator
I3J08_RS05220	COG0745	RESPONSE REGULATOR receiver
I3J08_RS05225	COG2205	protein histidine kinase activity
I3J08_RS05275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J08_RS05285	COG2171	N-acyltransferase activity
I3J08_RS05290	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J08_RS05295	COG0822	iron-sulfur transferase activity
I3J08_RS05300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J08_RS05305	COG0396	ATPase activity
I3J08_RS05315	COG0719	Fe-S assembly protein
I3J08_RS05330	COG1131	(ABC) transporter
I3J08_RS05360	COG0109	protoheme IX farnesyltransferase activity
I3J08_RS05370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J08_RS05385	COG0363	glucosamine-6-phosphate deaminase activity
I3J08_RS05395	COG3402	PFAM membrane-flanked domain
I3J08_RS05400	COG0166	Belongs to the GPI family
I3J08_RS05410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J08_RS05415	COG0149	triose-phosphate isomerase activity
I3J08_RS05420	COG0126	phosphoglycerate kinase activity
I3J08_RS05425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J08_RS05435	COG1481	regulation of sporulation
I3J08_RS05440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J08_RS05445	COG1660	Displays ATPase and GTPase activities
I3J08_RS05450	COG0322	excinuclease ABC activity
I3J08_RS05475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J08_RS05475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J08_RS05480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J08_RS05490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J08_RS05510	COG0556	nucleotide-excision repair
I3J08_RS05520	COG0584	glycerophosphoryl diester phosphodiesterase
I3J08_RS05525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J08_RS05535	COG2313	pseudouridylate synthase activity
I3J08_RS05565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J08_RS05570	COG0330	HflC and HflK could
I3J08_RS05590	COG0237	dephospho-CoA kinase activity
I3J08_RS05600	COG0539	negative regulation of cytoplasmic translation
I3J08_RS05605	COG0596	Alpha beta hydrolase
I3J08_RS05605	COG2226	methyltransferase
I3J08_RS05605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J08_RS05610	COG1643	Atp-dependent helicase
I3J08_RS05640	COG2050	protein possibly involved in aromatic compounds catabolism
I3J08_RS05660	COG0411	ABC transporter
I3J08_RS05710	COG1605	Chorismate mutase
I3J08_RS05710	COG0287	Prephenate dehydrogenase
I3J08_RS05725	COG0366	Alpha amylase catalytic
I3J08_RS05725	COG1470	cell adhesion involved in biofilm formation
I3J08_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS05750	COG1024	Enoyl-CoA hydratase
I3J08_RS05780	COG0183	Belongs to the thiolase family
I3J08_RS05785	COG1309	transcriptional regulator
I3J08_RS05795	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS05820	COG0069	glutamate synthase activity
I3J08_RS05820	COG0070	glutamate synthase
I3J08_RS05820	COG0067	glutamate synthase
I3J08_RS05855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J08_RS05860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J08_RS05865	COG2301	Belongs to the HpcH HpaI aldolase family
I3J08_RS05870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J08_RS05880	COG0159	tryptophan synthase activity
I3J08_RS05885	COG0133	tryptophan synthase activity
I3J08_RS05895	COG0134	indole-3-glycerol-phosphate synthase activity
I3J08_RS05915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J08_RS05920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J08_RS05935	COG0107	imidazoleglycerol-phosphate synthase activity
I3J08_RS05940	COG0251	oxidation-reduction process
I3J08_RS05945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J08_RS05950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J08_RS05960	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J08_RS05965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J08_RS05970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J08_RS05990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J08_RS06010	COG1432	Conserved Protein
I3J08_RS06020	COG0587	DNA-directed DNA polymerase activity
I3J08_RS06070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J08_RS06085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J08_RS06090	COG3599	regulation of cell shape
I3J08_RS06100	COG1799	cell septum assembly
I3J08_RS06110	COG1496	oxidoreductase activity
I3J08_RS06120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J08_RS06125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J08_RS06135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J08_RS06140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J08_RS06145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J08_RS06150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J08_RS06155	COG0768	penicillin binding
I3J08_RS06165	COG0275	rRNA processing
I3J08_RS06175	COG0714	Associated with various cellular activities
I3J08_RS06205	COG1121	(ABC) transporter
I3J08_RS06210	COG1511	domain protein
I3J08_RS06215	COG1309	transcriptional regulator
I3J08_RS06225	COG1233	COG1233 Phytoene dehydrogenase and related
I3J08_RS06240	COG0352	thiamine-phosphate diphosphorylase activity
I3J08_RS06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J08_RS06260	COG2022	thiamine diphosphate biosynthetic process
I3J08_RS06270	COG2022	thiamine diphosphate biosynthetic process
I3J08_RS06275	COG2815	serine threonine protein kinase
I3J08_RS06275	COG0515	serine threonine protein kinase
I3J08_RS06280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J08_RS06285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J08_RS06290	COG2193	ferroxidase activity
I3J08_RS06295	COG0243	molybdopterin cofactor binding
I3J08_RS06300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J08_RS06310	COG0205	6-phosphofructokinase activity
I3J08_RS06315	COG2197	response regulator
I3J08_RS06345	COG1940	carbohydrate kinase activity
I3J08_RS06355	COG0003	Pfam Anion-transporting ATPase
I3J08_RS06380	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS06430	COG2205	protein histidine kinase activity
I3J08_RS06435	COG0745	RESPONSE REGULATOR receiver
I3J08_RS06445	COG1929	Belongs to the glycerate kinase type-1 family
I3J08_RS06450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J08_RS06455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J08_RS06460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J08_RS06465	COG0723	plastoquinol--plastocyanin reductase activity
I3J08_RS06470	COG2010	Cytochrome c
I3J08_RS06475	COG1845	cytochrome c oxidase, subunit III
I3J08_RS06485	COG1376	ErfK ybiS ycfS ynhG family protein
I3J08_RS06495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J08_RS06500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J08_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J08_RS06530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J08_RS06540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J08_RS06545	COG2197	response regulator
I3J08_RS06550	COG4585	Histidine kinase
I3J08_RS06575	COG1132	(ABC) transporter
I3J08_RS06580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J08_RS06610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J08_RS06620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J08_RS06625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J08_RS06630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J08_RS06635	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J08_RS06645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J08_RS06675	COG1090	epimerase
I3J08_RS06690	COG0321	lipoyl(octanoyl) transferase activity
I3J08_RS06695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J08_RS06745	COG0181	hydroxymethylbilane synthase activity
I3J08_RS06770	COG0673	inositol 2-dehydrogenase activity
I3J08_RS06780	COG0745	RESPONSE REGULATOR receiver
I3J08_RS06820	COG2197	response regulator
I3J08_RS06850	COG1175	transmembrane transport
I3J08_RS06855	COG3833	ABC-type maltose transport systems, permease component
I3J08_RS06860	COG0366	Alpha amylase catalytic
I3J08_RS06865	COG1609	Transcriptional regulator
I3J08_RS06885	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J08_RS06900	COG0494	nUDIX hydrolase
I3J08_RS06905	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J08_RS06930	COG1228	amidohydrolase
I3J08_RS06945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J08_RS06960	COG0174	glutamine synthetase
I3J08_RS06995	COG2132	Multicopper oxidase
I3J08_RS07000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J08_RS07000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J08_RS07010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J08_RS07030	COG1994	Peptidase M50
I3J08_RS07065	COG5398	heme oxygenase
I3J08_RS07090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS07095	COG1120	ATPase activity
I3J08_RS07115	COG1834	amidinotransferase
I3J08_RS07130	COG2814	Major facilitator Superfamily
I3J08_RS07135	COG3540	Alkaline phosphatase
I3J08_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS07185	COG0395	ABC-type sugar transport system, permease component
I3J08_RS07195	COG1653	transport
I3J08_RS07200	COG1349	DNA-binding transcription factor activity
I3J08_RS07220	COG0789	Transcriptional regulator
I3J08_RS07235	COG3022	response to hydroperoxide
I3J08_RS07240	COG0800	Aldolase
I3J08_RS07260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J08_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS07280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J08_RS07285	COG2030	dehydratase
I3J08_RS07300	COG0183	Belongs to the thiolase family
I3J08_RS07320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS07330	COG2226	methyltransferase
I3J08_RS07335	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS07340	COG1309	transcriptional regulator
I3J08_RS07375	COG3845	ABC transporter
I3J08_RS07390	COG0183	Belongs to the thiolase family
I3J08_RS07395	COG2124	cytochrome p450
I3J08_RS07405	COG4122	O-methyltransferase activity
I3J08_RS07515	COG0582	viral genome integration into host DNA
I3J08_RS07540	COG0586	Pfam SNARE associated Golgi protein
I3J08_RS07550	COG1358	cellular component organization or biogenesis
I3J08_RS07595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J08_RS07600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J08_RS07620	COG4585	Histidine kinase
I3J08_RS07625	COG2197	response regulator
I3J08_RS07630	COG0667	Aldo Keto reductase
I3J08_RS07635	COG0789	Transcriptional regulator
I3J08_RS07660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J08_RS07665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J08_RS07670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J08_RS07705	COG2130	NADP-dependent
I3J08_RS07760	COG1136	(ABC) transporter
I3J08_RS07770	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS07830	COG1129	ABC transporter
I3J08_RS07830	COG0842	Transport permease protein
I3J08_RS07865	COG1070	Carbohydrate kinase
I3J08_RS07880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J08_RS07885	COG0358	DNA primase activity
I3J08_RS07895	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J08_RS07900	COG2949	membrane
I3J08_RS07920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J08_RS07940	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J08_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS07955	COG0531	amino acid
I3J08_RS07970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J08_RS07970	COG0574	Belongs to the PEP-utilizing enzyme family
I3J08_RS08010	COG0423	glycine-tRNA ligase activity
I3J08_RS08015	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J08_RS08015	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J08_RS08020	COG1121	(ABC) transporter
I3J08_RS08025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J08_RS08035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J08_RS08040	COG1381	Involved in DNA repair and RecF pathway recombination
I3J08_RS08055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J08_RS08070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J08_RS08110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J08_RS08120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J08_RS08125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J08_RS08130	COG1234	tRNA 3'-trailer cleavage
I3J08_RS08135	COG0537	adenosine 5'-monophosphoramidase activity
I3J08_RS08140	COG4946	Tricorn protease homolog
I3J08_RS08140	COG0793	Belongs to the peptidase S41A family
I3J08_RS08160	COG0484	heat shock protein binding
I3J08_RS08165	COG1420	regulation of RNA biosynthetic process
I3J08_RS08190	COG0481	GTPase activity
I3J08_RS08195	COG0268	Binds directly to 16S ribosomal RNA
I3J08_RS08230	COG1307	EDD domain protein, DegV family
I3J08_RS08240	COG0495	leucyl-tRNA aminoacylation
I3J08_RS08250	COG0588	phosphoglycerate mutase activity
I3J08_RS08255	COG0799	negative regulation of ribosome biogenesis
I3J08_RS08265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J08_RS08275	COG0501	Belongs to the peptidase M48B family
I3J08_RS08290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J08_RS08300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J08_RS08315	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS08320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J08_RS08325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J08_RS08330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J08_RS08340	COG1530	ribonuclease E activity
I3J08_RS08360	COG0772	Belongs to the SEDS family
I3J08_RS08380	COG1077	Cell shape determining protein MreB Mrl
I3J08_RS08385	COG0105	UTP biosynthetic process
I3J08_RS08395	COG0285	dihydrofolate synthase activity
I3J08_RS08400	COG4585	Histidine kinase
I3J08_RS08405	COG0525	valine-tRNA ligase activity
I3J08_RS08415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J08_RS08420	COG0740	serine-type endopeptidase activity
I3J08_RS08425	COG0740	serine-type endopeptidase activity
I3J08_RS08430	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J08_RS08450	COG3594	Acyltransferase
I3J08_RS08455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J08_RS08470	COG0475	glutathione-regulated potassium exporter activity
I3J08_RS08485	COG4552	Acetyltransferase involved in intracellular survival and related
I3J08_RS08500	COG1113	amino acid transport
I3J08_RS08510	COG1113	amino acid transport
I3J08_RS08515	COG0588	phosphoglycerate mutase activity
I3J08_RS08525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J08_RS08535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J08_RS08540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J08_RS08610	COG0668	transmembrane transport
I3J08_RS08630	COG1175	transmembrane transport
I3J08_RS08635	COG0395	ABC-type sugar transport system, permease component
I3J08_RS08640	COG1486	melibiose metabolic process
I3J08_RS08655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J08_RS08700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J08_RS08730	COG0629	single-stranded DNA binding
I3J08_RS08770	COG1203	CRISPR-associated helicase, Cas3
I3J08_RS08780	COG1518	maintenance of DNA repeat elements
I3J08_RS08785	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J08_RS08795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J08_RS08825	COG0475	glutathione-regulated potassium exporter activity
I3J08_RS08835	COG0561	phosphatase activity
I3J08_RS08865	COG0494	nUDIX hydrolase
I3J08_RS08875	COG2954	triphosphatase activity
I3J08_RS08885	COG2197	response regulator
I3J08_RS08890	COG0105	UTP biosynthetic process
I3J08_RS08950	COG1131	(ABC) transporter
I3J08_RS08970	COG3962	Belongs to the TPP enzyme family
I3J08_RS08975	COG3718	enzyme involved in inositol metabolism
I3J08_RS08985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J08_RS09010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J08_RS09020	COG1595	DNA-templated transcription, initiation
I3J08_RS09035	COG0673	inositol 2-dehydrogenase activity
I3J08_RS09040	COG1609	Transcriptional regulator
I3J08_RS09055	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J08_RS09120	COG1674	ftsk spoiiie
I3J08_RS09140	COG3960	tartronate-semialdehyde synthase activity
I3J08_RS09150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J08_RS09165	COG1946	Acyl-CoA thioesterase
I3J08_RS09170	COG2124	cytochrome p450
I3J08_RS09180	COG1309	transcriptional regulator
I3J08_RS09185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J08_RS09200	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS09210	COG0076	glutamate decarboxylase activity
I3J08_RS09215	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J08_RS09240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J08_RS09245	COG0589	response to stress
I3J08_RS09255	COG4977	sequence-specific DNA binding
I3J08_RS09260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J08_RS09275	COG0745	RESPONSE REGULATOR receiver
I3J08_RS09315	COG0406	alpha-ribazole phosphatase activity
I3J08_RS09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS09360	COG0154	amidase activity
I3J08_RS09370	COG0765	amino acid transport
I3J08_RS09375	COG0765	amino acid transport
I3J08_RS09380	COG1126	abc transporter atp-binding protein
I3J08_RS09450	COG0673	inositol 2-dehydrogenase activity
I3J08_RS09460	COG0706	membrane insertase activity
I3J08_RS09490	COG2733	membrane
I3J08_RS09515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J08_RS09525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J08_RS09555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J08_RS09565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J08_RS09570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J08_RS09575	COG1263	PTS System
I3J08_RS09580	COG1263	PTS System
I3J08_RS09585	COG1234	tRNA 3'-trailer cleavage
I3J08_RS09600	COG1120	ATPase activity
I3J08_RS09605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS09610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J08_RS09620	COG1113	amino acid transport
I3J08_RS09630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J08_RS09640	COG1335	isochorismatase
I3J08_RS09680	COG0277	FAD linked oxidase domain protein
I3J08_RS09700	COG5002	protein histidine kinase activity
I3J08_RS09705	COG0745	RESPONSE REGULATOR receiver
I3J08_RS09710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J08_RS09735	COG3654	unkown
I3J08_RS09775	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J08_RS09780	COG0395	ABC-type sugar transport system, permease component
I3J08_RS09785	COG1175	transmembrane transport
I3J08_RS09800	COG1678	Uncharacterized ACR, COG1678
I3J08_RS09805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J08_RS09810	COG0776	regulation of translation
I3J08_RS09820	COG3973	AAA domain
I3J08_RS09845	COG0583	DNA-binding transcription factor activity
I3J08_RS09860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J08_RS09865	COG0793	Belongs to the peptidase S41A family
I3J08_RS09875	COG2884	Cell division ATP-binding protein ftsE
I3J08_RS09885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J08_RS09890	COG0515	serine threonine protein kinase
I3J08_RS09895	COG0515	serine threonine protein kinase
I3J08_RS09910	COG1175	transmembrane transport
I3J08_RS09915	COG0395	ABC-type sugar transport system, permease component
I3J08_RS09925	COG2902	Dehydrogenase
I3J08_RS09950	COG0653	protein targeting
I3J08_RS09960	COG3214	Protein conserved in bacteria
I3J08_RS09965	COG2197	response regulator
I3J08_RS09970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J08_RS09980	COG0823	Involved in the tonB-independent uptake of proteins
I3J08_RS09985	COG5000	phosphorelay sensor kinase activity
I3J08_RS09985	COG5002	protein histidine kinase activity
I3J08_RS09990	COG0745	RESPONSE REGULATOR receiver
I3J08_RS09995	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J08_RS10005	COG2826	transposase and inactivated derivatives, IS30 family
I3J08_RS10030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J08_RS10040	COG1482	cell wall glycoprotein biosynthetic process
I3J08_RS10050	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J08_RS10055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J08_RS10090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J08_RS10095	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J08_RS10095	COG0778	Nitroreductase
I3J08_RS10120	COG1316	TRANSCRIPTIONal
I3J08_RS10140	COG1316	TRANSCRIPTIONal
I3J08_RS10145	COG1607	acyl-coa hydrolase
I3J08_RS10150	COG1316	TRANSCRIPTIONal
I3J08_RS10155	COG0596	Alpha beta hydrolase
I3J08_RS10160	COG1309	transcriptional regulator
I3J08_RS10245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J08_RS10280	COG2205	protein histidine kinase activity
I3J08_RS10285	COG0745	RESPONSE REGULATOR receiver
I3J08_RS10290	COG3104	oligopeptide transport
I3J08_RS10315	COG1191	sigma factor activity
I3J08_RS10340	COG1228	amidohydrolase
I3J08_RS10370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J08_RS10430	COG1737	Transcriptional regulator
I3J08_RS10445	COG2755	lipolytic protein G-D-S-L family
I3J08_RS10450	COG0183	Belongs to the thiolase family
I3J08_RS10480	COG0577	efflux transmembrane transporter activity
I3J08_RS10480	COG1136	(ABC) transporter
I3J08_RS10485	COG0577	efflux transmembrane transporter activity
I3J08_RS10485	COG1136	(ABC) transporter
I3J08_RS10490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J08_RS10495	COG1252	NADH dehydrogenase
I3J08_RS10515	COG0148	phosphopyruvate hydratase activity
I3J08_RS10525	COG1652	LysM domain
I3J08_RS10555	COG0515	serine threonine protein kinase
I3J08_RS10555	COG2815	serine threonine protein kinase
I3J08_RS10580	COG1595	DNA-templated transcription, initiation
I3J08_RS10590	COG0577	efflux transmembrane transporter activity
I3J08_RS10595	COG1136	(ABC) transporter
I3J08_RS10610	COG0477	Major facilitator Superfamily
I3J08_RS10640	COG4585	Histidine kinase
I3J08_RS10650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J08_RS10655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J08_RS10660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J08_RS10665	COG0193	aminoacyl-tRNA hydrolase activity
I3J08_RS10675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J08_RS10685	COG1309	transcriptional regulator
I3J08_RS10690	COG4106	trans-aconitate 2-methyltransferase activity
I3J08_RS10700	COG2197	response regulator
I3J08_RS10705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J08_RS10735	COG0488	(ABC) transporter
I3J08_RS10760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J08_RS10765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J08_RS10775	COG0084	hydrolase, TatD family'
I3J08_RS10805	COG0442	prolyl-tRNA aminoacylation
I3J08_RS10825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J08_RS10830	COG3409	Peptidoglycan-binding domain 1 protein
I3J08_RS10855	COG0124	histidyl-tRNA synthetase
I3J08_RS10895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J08_RS10900	COG1122	ATPase activity
I3J08_RS10910	COG0310	cobalt ion transport
I3J08_RS10920	COG2409	Drug exporters of the RND superfamily
I3J08_RS10930	COG4946	Tricorn protease homolog
I3J08_RS10930	COG0793	Belongs to the peptidase S41A family
I3J08_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS10940	COG2267	carboxylic ester hydrolase activity
I3J08_RS10945	COG2072	flavoprotein involved in K transport
I3J08_RS10990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J08_RS10995	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J08_RS10995	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J08_RS11000	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J08_RS11010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J08_RS11015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J08_RS11040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J08_RS11050	COG1970	mechanosensitive ion channel activity
I3J08_RS11065	COG3191	aminopeptidase activity
I3J08_RS11075	COG0477	Major facilitator Superfamily
I3J08_RS11095	COG3384	dioxygenase
I3J08_RS11100	COG1846	Transcriptional regulator
I3J08_RS11125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J08_RS11125	COG1648	precorrin-2 dehydrogenase activity
I3J08_RS11130	COG0181	hydroxymethylbilane synthase activity
I3J08_RS11135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J08_RS11140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J08_RS11155	COG1595	DNA-templated transcription, initiation
I3J08_RS11190	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J08_RS11215	COG0180	Tryptophanyl-tRNA synthetase
I3J08_RS11220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J08_RS11225	COG1252	NADH dehydrogenase
I3J08_RS11230	COG1595	DNA-templated transcription, initiation
I3J08_RS11235	COG2226	methyltransferase
I3J08_RS11255	COG0129	dihydroxy-acid dehydratase activity
I3J08_RS11265	COG0248	Ppx GppA phosphatase
I3J08_RS11285	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J08_RS11295	COG0671	phosphoesterase, PA-phosphatase related
I3J08_RS11300	COG1194	a g-specific adenine glycosylase
I3J08_RS11305	COG1595	DNA-templated transcription, initiation
I3J08_RS11315	COG0745	RESPONSE REGULATOR receiver
I3J08_RS11320	COG2205	protein histidine kinase activity
I3J08_RS11325	COG0739	heme binding
I3J08_RS11335	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J08_RS11350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J08_RS11370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J08_RS11380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J08_RS11385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J08_RS11400	COG2197	response regulator
I3J08_RS11415	COG0649	NAD binding
I3J08_RS11430	COG1174	glycine betaine transport
I3J08_RS11455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J08_RS11470	COG0302	gtp cyclohydrolase
I3J08_RS11485	COG0037	tRNA processing
I3J08_RS11495	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J08_RS11500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J08_RS11515	COG0076	glutamate decarboxylase activity
I3J08_RS11530	COG2318	DinB family
I3J08_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS11575	COG0110	maltose O-acetyltransferase activity
I3J08_RS11580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J08_RS11580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J08_RS11585	COG1132	(ABC) transporter
I3J08_RS11695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J08_RS11855	COG0305	Participates in initiation and elongation during chromosome replication
I3J08_RS11935	COG0791	NLP P60 protein
I3J08_RS11980	COG1061	Type III restriction enzyme res subunit
I3J08_RS12020	COG0477	Major facilitator Superfamily
I3J08_RS12030	COG0470	DNA polymerase III
I3J08_RS12035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J08_RS12040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J08_RS12040	COG1754	DNA topoisomerase type I activity
I3J08_RS12050	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J08_RS12060	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J08_RS12065	COG2172	sigma factor antagonist activity
I3J08_RS12070	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J08_RS12075	COG1111	helicase
I3J08_RS12075	COG1205	dead DEAH box helicase
I3J08_RS12135	COG0659	secondary active sulfate transmembrane transporter activity
I3J08_RS12140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J08_RS12145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J08_RS12155	COG2267	carboxylic ester hydrolase activity
I3J08_RS12185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J08_RS12215	COG0003	Pfam Anion-transporting ATPase
I3J08_RS12225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J08_RS12230	COG1610	YqeY-like protein
I3J08_RS12235	COG1408	metallophosphoesterase
I3J08_RS12255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J08_RS12340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J08_RS12370	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J08_RS12385	COG2091	lysine biosynthetic process via aminoadipic acid
I3J08_RS12400	COG2124	cytochrome p450
I3J08_RS12425	COG1595	DNA-templated transcription, initiation
I3J08_RS12430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J08_RS12445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J08_RS12450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J08_RS12465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J08_RS12500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS12505	COG2319	Wd-40 repeat
I3J08_RS12505	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J08_RS12520	COG1802	Transcriptional regulator
I3J08_RS12525	COG0463	Glycosyl transferase, family 2
I3J08_RS12555	COG2124	cytochrome p450
I3J08_RS12565	COG4585	Histidine kinase
I3J08_RS12600	COG0477	Major facilitator Superfamily
I3J08_RS12605	COG0191	fructose-bisphosphate aldolase activity
I3J08_RS12610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J08_RS12625	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J08_RS12655	COG0542	response to heat
I3J08_RS12675	COG0789	Transcriptional regulator
I3J08_RS12680	COG0484	heat shock protein binding
I3J08_RS12685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J08_RS12690	COG0443	Heat shock 70 kDa protein
I3J08_RS12695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J08_RS12700	COG0247	lactate metabolic process
I3J08_RS12700	COG2181	nitrate reductase activity
I3J08_RS12715	COG0717	Belongs to the dCTP deaminase family
I3J08_RS12765	COG0588	phosphoglycerate mutase activity
I3J08_RS12770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J08_RS12780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J08_RS12805	COG2409	Drug exporters of the RND superfamily
I3J08_RS12810	COG4585	Histidine kinase
I3J08_RS12815	COG2197	response regulator
I3J08_RS12830	COG4171	peptide transport system, permease
I3J08_RS12835	COG0601	transmembrane transport
I3J08_RS12840	COG4166	transmembrane transport
I3J08_RS12855	COG0019	diaminopimelate decarboxylase activity
I3J08_RS12860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J08_RS12865	COG0534	Mate efflux family protein
I3J08_RS12875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J08_RS12925	COG3903	Transcriptional regulator
I3J08_RS12925	COG3629	intracellular signal transduction
I3J08_RS12950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J08_RS13010	COG0577	efflux transmembrane transporter activity
I3J08_RS13020	COG2197	response regulator
I3J08_RS13035	COG0436	Aminotransferase
I3J08_RS13055	COG1857	crispr-associated protein
I3J08_RS13160	COG2826	transposase and inactivated derivatives, IS30 family
I3J08_RS13200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J08_RS13205	COG2226	methyltransferase
I3J08_RS13215	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J08_RS13295	COG3345	alpha-galactosidase
I3J08_RS13300	COG0598	Magnesium transport protein CorA
I3J08_RS13330	COG0431	NADPH-dependent FMN reductase
I3J08_RS13335	COG1672	PFAM Archaeal ATPase
I3J08_RS13335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J08_RS13360	COG0431	NADPH-dependent FMN reductase
I3J08_RS13380	COG0477	Major facilitator Superfamily
I3J08_RS13385	COG0745	RESPONSE REGULATOR receiver
I3J08_RS13415	COG0784	Response regulator, receiver
I3J08_RS13420	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS13425	COG1595	DNA-templated transcription, initiation
I3J08_RS13450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J08_RS13455	COG0587	DNA-directed DNA polymerase activity
I3J08_RS13485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J08_RS13515	COG0006	proline dipeptidase activity
I3J08_RS13535	COG1999	signal sequence binding
I3J08_RS13550	COG2837	iron assimilation
I3J08_RS13555	COG0077	Prephenate dehydratase
I3J08_RS13560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J08_RS13565	COG0561	phosphatase activity
I3J08_RS13600	COG1131	(ABC) transporter
I3J08_RS13610	COG0561	phosphatase activity
I3J08_RS13620	COG4988	ABC transporter
I3J08_RS13625	COG1294	oxidase, subunit
I3J08_RS13630	COG1271	oxidase subunit
I3J08_RS13635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J08_RS13640	COG1609	Transcriptional regulator
I3J08_RS13655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J08_RS13675	COG0662	Cupin 2, conserved barrel domain protein
I3J08_RS13680	COG1950	PFAM Membrane protein of
I3J08_RS13685	COG0626	cystathionine gamma-synthase activity
I3J08_RS13720	COG0305	Participates in initiation and elongation during chromosome replication
I3J08_RS13730	COG0359	binds to the 23S rRNA
I3J08_RS13735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J08_RS13740	COG0629	single-stranded DNA binding
I3J08_RS13745	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J08_RS13770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J08_RS13790	COG0617	tRNA 3'-terminal CCA addition
I3J08_RS13805	COG2815	serine threonine protein kinase
I3J08_RS13805	COG0515	serine threonine protein kinase
I3J08_RS13810	COG1595	DNA-templated transcription, initiation
I3J08_RS13820	COG0492	ferredoxin-NADP+ reductase activity
I3J08_RS13825	COG3118	belongs to the thioredoxin family
I3J08_RS13840	COG1192	Involved in chromosome partitioning
I3J08_RS13845	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J08_RS13855	COG0706	membrane insertase activity
I3J08_RS13860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J08_RS13865	COG0594	ribonuclease P activity
I3J08_RS13870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J08_RS13880	COG0592	DNA-directed DNA polymerase activity
I3J08_RS13885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J08_RS13890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J08_RS13895	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J08_RS13905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J08_RS13925	COG0515	serine threonine protein kinase
I3J08_RS13940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS13945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS13950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J08_RS13955	COG2175	clavaminate synthase activity
I3J08_RS13960	COG0667	Aldo Keto reductase
I3J08_RS13975	COG1672	PFAM Archaeal ATPase
I3J08_RS13975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J08_RS13980	COG1280	lysine exporter protein (LysE YggA)
I3J08_RS13985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J08_RS13990	COG1446	asparaginase
I3J08_RS14020	COG0705	Rhomboid family
I3J08_RS14020	COG0457	Tetratricopeptide repeat
I3J08_RS14035	COG3764	Sortase (surface protein transpeptidase)
I3J08_RS14050	COG3764	Sortase (surface protein transpeptidase)
I3J08_RS14055	COG3764	Sortase (surface protein transpeptidase)
I3J08_RS14060	COG0515	serine threonine protein kinase
I3J08_RS14065	COG0768	penicillin binding
I3J08_RS14080	COG1716	ATPase activity
I3J08_RS14085	COG1716	ATPase activity
I3J08_RS14095	COG0577	efflux transmembrane transporter activity
I3J08_RS14095	COG1136	(ABC) transporter
I3J08_RS14100	COG0577	efflux transmembrane transporter activity
I3J08_RS14100	COG1136	(ABC) transporter
I3J08_RS14125	COG4585	Histidine kinase
I3J08_RS14130	COG2197	response regulator
I3J08_RS14145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J08_RS14150	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS14155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J08_RS14160	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J08_RS14165	COG3396	Phenylacetate-CoA oxygenase
I3J08_RS14170	COG3460	Phenylacetate-CoA oxygenase
I3J08_RS14175	COG3396	Phenylacetate-CoA oxygenase
I3J08_RS14200	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J08_RS14205	COG1309	transcriptional regulator
I3J08_RS14210	COG1522	sequence-specific DNA binding
I3J08_RS14235	COG0303	'Molybdopterin
I3J08_RS14265	COG1136	(ABC) transporter
I3J08_RS14265	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J08_RS14280	COG0515	serine threonine protein kinase
I3J08_RS14285	COG0515	serine threonine protein kinase
I3J08_RS14310	COG0022	dehydrogenase e1 component
I3J08_RS14315	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J08_RS14330	COG2271	Major facilitator Superfamily
I3J08_RS14350	COG1362	aminopeptidase activity
I3J08_RS14360	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS14385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J08_RS14405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J08_RS14410	COG0745	RESPONSE REGULATOR receiver
I3J08_RS14415	COG2205	protein histidine kinase activity
I3J08_RS14420	COG2304	oxidoreductase activity
I3J08_RS14470	COG1191	sigma factor activity
I3J08_RS14475	COG1191	sigma factor activity
I3J08_RS14520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J08_RS14535	COG0433	COG0433 Predicted ATPase
I3J08_RS14540	COG2234	aminopeptidase activity
I3J08_RS14570	COG0477	Major facilitator Superfamily
I3J08_RS14635	COG3903	Transcriptional regulator
I3J08_RS14635	COG3629	intracellular signal transduction
I3J08_RS14665	COG2826	transposase and inactivated derivatives, IS30 family
I3J08_RS14705	COG0105	UTP biosynthetic process
I3J08_RS14715	COG1051	belongs to the nudix hydrolase family
I3J08_RS14720	COG0017	Asparaginyl-tRNA synthetase
I3J08_RS14745	COG0151	Belongs to the GarS family
I3J08_RS14760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J08_RS14770	COG2197	response regulator
I3J08_RS14805	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J08_RS14810	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J08_RS14815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J08_RS14845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J08_RS14880	COG1643	Atp-dependent helicase
I3J08_RS14890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J08_RS14890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J08_RS14895	COG0785	Cytochrome C biogenesis protein
I3J08_RS14930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J08_RS14935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J08_RS14945	COG0513	Belongs to the DEAD box helicase family
I3J08_RS14955	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J08_RS15010	COG0739	heme binding
I3J08_RS15010	COG0741	lytic transglycosylase activity
I3J08_RS15010	COG1196	nuclear chromosome segregation
I3J08_RS15020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J08_RS15025	COG0579	oxidoreductase
I3J08_RS15120	COG1196	nuclear chromosome segregation
I3J08_RS15120	COG0741	lytic transglycosylase activity
I3J08_RS15120	COG0739	heme binding
I3J08_RS15125	COG0671	phosphoesterase, PA-phosphatase related
I3J08_RS15145	COG1937	Protein conserved in bacteria
I3J08_RS15155	COG0306	phosphate transporter
I3J08_RS15180	COG0494	nUDIX hydrolase
I3J08_RS15180	COG0406	alpha-ribazole phosphatase activity
I3J08_RS15190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J08_RS15195	COG0456	acetyltransferase
I3J08_RS15215	COG4085	toxin activity
I3J08_RS15215	COG1525	nuclease
I3J08_RS15215	COG0737	Belongs to the 5'-nucleotidase family
I3J08_RS15225	COG2188	Transcriptional regulator
I3J08_RS15240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J08_RS15255	COG1609	Transcriptional regulator
I3J08_RS15260	COG0745	RESPONSE REGULATOR receiver
I3J08_RS15280	COG1309	transcriptional regulator
I3J08_RS15305	COG3485	protocatechuate 3,4-dioxygenase
I3J08_RS15320	COG1490	D-aminoacyl-tRNA deacylase activity
I3J08_RS15380	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS15405	COG2211	Major facilitator Superfamily
I3J08_RS15410	COG0588	phosphoglycerate mutase activity
I3J08_RS15425	COG5002	protein histidine kinase activity
I3J08_RS15440	COG1329	Transcriptional regulator
I3J08_RS15445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J08_RS15450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J08_RS15460	COG0215	cysteine-tRNA ligase activity
I3J08_RS15465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J08_RS15475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J08_RS15485	COG3842	ATPase activity
I3J08_RS15500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J08_RS15565	COG0463	Glycosyl transferase, family 2
I3J08_RS15590	COG2182	Extracellular solute-binding protein
I3J08_RS15595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J08_RS15610	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J08_RS15615	COG0191	fructose-bisphosphate aldolase activity
I3J08_RS15640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J08_RS15660	COG2197	response regulator
I3J08_RS15680	COG1605	Chorismate mutase
I3J08_RS15685	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS15695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J08_RS15700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J08_RS15775	COG1595	DNA-templated transcription, initiation
I3J08_RS15790	COG3973	AAA domain
I3J08_RS15800	COG1061	Type III restriction enzyme res subunit
I3J08_RS15835	COG1278	Cold shock
I3J08_RS15840	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J08_RS15845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J08_RS15855	COG2814	Major facilitator Superfamily
I3J08_RS15875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J08_RS15885	COG2252	PERMEase
I3J08_RS15920	COG0667	Aldo Keto reductase
I3J08_RS15940	COG1122	ATPase activity
I3J08_RS15980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J08_RS15995	COG3903	Transcriptional regulator
I3J08_RS15995	COG3629	intracellular signal transduction
I3J08_RS16005	COG0463	Glycosyl transferase, family 2
I3J08_RS16045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J08_RS16055	COG0277	FAD linked oxidase domain protein
I3J08_RS16055	COG0247	lactate metabolic process
I3J08_RS16070	COG0745	RESPONSE REGULATOR receiver
I3J08_RS16075	COG2205	protein histidine kinase activity
I3J08_RS16090	COG0583	DNA-binding transcription factor activity
I3J08_RS16125	COG1136	(ABC) transporter
I3J08_RS16125	COG0577	efflux transmembrane transporter activity
I3J08_RS16130	COG0577	efflux transmembrane transporter activity
I3J08_RS16160	COG0726	polysaccharide deacetylase
I3J08_RS16205	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS16275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J08_RS16290	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS16310	COG0259	pyridoxamine-phosphate oxidase activity
I3J08_RS16320	COG4821	SIS domain
I3J08_RS16330	COG2945	thiolester hydrolase activity
I3J08_RS16330	COG0596	Alpha beta hydrolase
I3J08_RS16400	COG3397	chitin binding
I3J08_RS16405	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS16415	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS16420	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS16440	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS16450	COG1917	Cupin 2, conserved barrel domain protein
I3J08_RS16450	COG4977	sequence-specific DNA binding
I3J08_RS16455	COG2271	Major facilitator Superfamily
I3J08_RS16460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J08_RS16475	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J08_RS16480	COG0477	Major facilitator Superfamily
I3J08_RS16480	COG2814	Major facilitator Superfamily
I3J08_RS16485	COG0456	acetyltransferase
I3J08_RS16495	COG1024	Enoyl-CoA hydratase
I3J08_RS16505	COG2072	flavoprotein involved in K transport
I3J08_RS16520	COG0259	pyridoxamine-phosphate oxidase activity
I3J08_RS16545	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS16555	COG0702	epimerase
I3J08_RS16575	COG1309	transcriptional regulator
I3J08_RS16595	COG1725	Transcriptional regulator
I3J08_RS16670	COG1136	(ABC) transporter
I3J08_RS16695	COG0596	Alpha beta hydrolase
I3J08_RS16700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J08_RS16805	COG0113	porphobilinogen synthase activity
I3J08_RS16825	COG0018	arginyl-trna synthetase
I3J08_RS16830	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J08_RS16845	COG0626	cystathionine gamma-synthase activity
I3J08_RS16850	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J08_RS16890	COG1690	Belongs to the RtcB family
I3J08_RS16895	COG0402	S-adenosylhomocysteine deaminase activity
I3J08_RS16910	COG1742	UPF0060 membrane protein
I3J08_RS16920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J08_RS16935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J08_RS16940	COG0406	alpha-ribazole phosphatase activity
I3J08_RS16945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J08_RS16950	COG0785	Cytochrome C biogenesis protein
I3J08_RS16955	COG1333	cytochrome c biogenesis protein
I3J08_RS16960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J08_RS16970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J08_RS16975	COG0109	protoheme IX farnesyltransferase activity
I3J08_RS16980	COG0163	prenyltransferase activity
I3J08_RS16990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J08_RS17010	COG1823	symporter activity
I3J08_RS17015	COG1278	Cold shock
I3J08_RS17020	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J08_RS17025	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J08_RS17035	COG2226	methyltransferase
I3J08_RS17065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17075	COG0649	NAD binding
I3J08_RS17085	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J08_RS17090	COG1034	ATP synthesis coupled electron transport
I3J08_RS17095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J08_RS17100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17105	COG0839	Belongs to the complex I subunit 6 family
I3J08_RS17110	COG0713	ATP synthesis coupled electron transport
I3J08_RS17115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J08_RS17125	COG1007	ATP synthesis coupled electron transport
I3J08_RS17130	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J08_RS17135	COG2936	dipeptidyl-peptidase activity
I3J08_RS17140	COG0142	geranyltranstransferase activity
I3J08_RS17165	COG2234	aminopeptidase activity
I3J08_RS17165	COG4935	Belongs to the peptidase S8 family
I3J08_RS17180	COG1733	regulation of RNA biosynthetic process
I3J08_RS17205	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J08_RS17210	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J08_RS17210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J08_RS17225	COG4585	Histidine kinase
I3J08_RS17230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J08_RS17250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J08_RS17255	COG0839	Belongs to the complex I subunit 6 family
I3J08_RS17260	COG0713	ATP synthesis coupled electron transport
I3J08_RS17275	COG1007	ATP synthesis coupled electron transport
I3J08_RS17280	COG0501	Belongs to the peptidase M48B family
I3J08_RS17285	COG3304	Inner membrane component domain
I3J08_RS17295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J08_RS17300	COG1666	GTP binding
I3J08_RS17320	COG0702	epimerase
I3J08_RS17340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J08_RS17345	COG2030	dehydratase
I3J08_RS17355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J08_RS17360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J08_RS17365	COG0436	Aminotransferase
I3J08_RS17375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J08_RS17385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J08_RS17390	COG0081	regulation of translation
I3J08_RS17395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J08_RS17400	COG0222	ribosome binding
I3J08_RS17405	COG0085	RNA polymerase activity
I3J08_RS17410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J08_RS17415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J08_RS17420	COG0049	tRNA binding
I3J08_RS17425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J08_RS17430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J08_RS17440	COG0051	transcription antitermination factor activity, RNA binding
I3J08_RS17445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J08_RS17450	COG0088	Forms part of the polypeptide exit tunnel
I3J08_RS17455	COG0089	rRNA binding
I3J08_RS17460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J08_RS17465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J08_RS17470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J08_RS17475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J08_RS17480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J08_RS17485	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J08_RS17490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J08_RS17495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J08_RS17500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J08_RS17505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J08_RS17510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J08_RS17515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J08_RS17520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J08_RS17525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J08_RS17530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J08_RS17535	COG1841	ribosomal large subunit assembly
I3J08_RS17540	COG0200	Binds to the 23S rRNA
I3J08_RS17550	COG0563	adenylate kinase activity
I3J08_RS17560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J08_RS17565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J08_RS17570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J08_RS17575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J08_RS17580	COG0202	RNA polymerase activity
I3J08_RS17585	COG0203	ribosomal protein L17
I3J08_RS17590	COG0101	tRNA pseudouridine synthase activity
I3J08_RS17600	COG0488	(ABC) transporter
I3J08_RS17605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J08_RS17610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J08_RS17615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J08_RS17620	COG1072	(Pantothenic acid kinase))
I3J08_RS17625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J08_RS17630	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J08_RS17650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J08_RS17660	COG0802	atpase or kinase
I3J08_RS17685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J08_RS17710	COG4941	Belongs to the sigma-70 factor family
I3J08_RS17720	COG0726	polysaccharide deacetylase
I3J08_RS17725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J08_RS17730	COG0459	protein refolding
I3J08_RS17735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J08_RS17750	COG0583	DNA-binding transcription factor activity
I3J08_RS17760	COG2197	response regulator
I3J08_RS17765	COG1595	DNA-templated transcription, initiation
I3J08_RS17775	COG0516	GMP reductase activity
I3J08_RS17785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J08_RS17805	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS17825	COG0519	Catalyzes the synthesis of GMP from XMP
I3J08_RS17825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J08_RS17850	COG2197	response regulator
I3J08_RS17870	COG0739	heme binding
I3J08_RS17880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS17880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS17895	COG0714	Associated with various cellular activities
I3J08_RS17905	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J08_RS17910	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J08_RS17940	COG0138	bifunctional purine biosynthesis protein purh
I3J08_RS17955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J08_RS17970	COG0039	L-malate dehydrogenase activity
I3J08_RS17980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J08_RS18020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J08_RS18030	COG0754	glutathionylspermidine amidase activity
I3J08_RS18035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J08_RS18040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J08_RS18045	COG0180	Tryptophanyl-tRNA synthetase
I3J08_RS18070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J08_RS18075	COG1295	ribonuclease BN
I3J08_RS18080	COG1686	Belongs to the peptidase S11 family
I3J08_RS18090	COG1408	metallophosphoesterase
I3J08_RS18100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J08_RS18105	COG1053	succinate dehydrogenase
I3J08_RS18115	COG2009	succinate dehydrogenase
I3J08_RS18120	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J08_RS18130	COG1595	DNA-templated transcription, initiation
I3J08_RS18145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS18145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS18160	COG0517	IMP dehydrogenase activity
I3J08_RS18160	COG0516	GMP reductase activity
I3J08_RS18175	COG1216	Glycosyl transferase, family 2
I3J08_RS18185	COG1083	cytidylyl-transferase
I3J08_RS18190	COG2089	acid synthase
I3J08_RS18200	COG1473	amidohydrolase
I3J08_RS18200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J08_RS18205	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J08_RS18210	COG3845	ABC transporter
I3J08_RS18215	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J08_RS18220	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J08_RS18255	COG2814	Major facilitator Superfamily
I3J08_RS18260	COG0583	DNA-binding transcription factor activity
I3J08_RS18275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J08_RS18300	COG2205	protein histidine kinase activity
I3J08_RS18305	COG0745	RESPONSE REGULATOR receiver
I3J08_RS18310	COG1595	DNA-templated transcription, initiation
I3J08_RS18325	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS18330	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS18360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J08_RS18390	COG4770	biotin carboxylase activity
I3J08_RS18395	COG0424	maF-like protein
I3J08_RS18405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J08_RS18420	COG1024	Enoyl-CoA hydratase
I3J08_RS18430	COG2986	histidine ammonia-lyase
I3J08_RS18445	COG1064	alcohol dehydrogenase
I3J08_RS18465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J08_RS18505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J08_RS18525	COG2188	Transcriptional regulator
I3J08_RS18535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J08_RS18545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J08_RS18575	COG1331	Highly conserved protein containing a thioredoxin domain
I3J08_RS18580	COG1309	transcriptional regulator
I3J08_RS18590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J08_RS18630	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS18635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J08_RS18645	COG0728	peptidoglycan biosynthetic process
I3J08_RS18680	COG0492	ferredoxin-NADP+ reductase activity
I3J08_RS18740	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J08_RS18755	COG1414	Transcriptional regulator
I3J08_RS18760	COG0251	oxidation-reduction process
I3J08_RS18765	COG2610	gluconate transmembrane transporter activity
I3J08_RS18790	COG2894	cell division
I3J08_RS18820	COG4585	Histidine kinase
I3J08_RS18845	COG2885	chlorophyll binding
I3J08_RS18870	COG0667	Aldo Keto reductase
I3J08_RS18875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J08_RS18880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J08_RS18895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J08_RS18900	COG0450	alkyl hydroperoxide reductase
I3J08_RS18915	COG1136	(ABC) transporter
I3J08_RS18935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J08_RS18955	COG0114	fumarate hydratase activity
I3J08_RS18965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J08_RS18965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J08_RS18990	COG0778	Nitroreductase
I3J08_RS18995	COG1722	exodeoxyribonuclease VII activity
I3J08_RS19000	COG1570	exodeoxyribonuclease VII activity
I3J08_RS19005	COG0531	amino acid
I3J08_RS19010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J08_RS19025	COG0012	GTP binding
I3J08_RS19075	COG1053	succinate dehydrogenase
I3J08_RS19095	COG1217	gtp-binding protein TYPA
I3J08_RS19100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS19105	COG4166	transmembrane transport
I3J08_RS19115	COG0444	Belongs to the ABC transporter superfamily
I3J08_RS19120	COG4608	Belongs to the ABC transporter superfamily
I3J08_RS19135	COG0601	transmembrane transport
I3J08_RS19140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS19145	COG0444	Belongs to the ABC transporter superfamily
I3J08_RS19150	COG4608	Belongs to the ABC transporter superfamily
I3J08_RS19165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J08_RS19205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J08_RS19210	COG1611	Belongs to the LOG family
I3J08_RS19215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J08_RS19225	COG0519	Catalyzes the synthesis of GMP from XMP
I3J08_RS19230	COG1024	Enoyl-CoA hydratase
I3J08_RS19245	COG1595	DNA-templated transcription, initiation
I3J08_RS19255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J08_RS19260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J08_RS19295	COG0598	Magnesium transport protein CorA
I3J08_RS19315	COG2095	MarC family integral membrane protein
I3J08_RS19325	COG1432	Conserved Protein
I3J08_RS19350	COG0513	Belongs to the DEAD box helicase family
I3J08_RS19380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J08_RS19380	COG0596	Alpha beta hydrolase
I3J08_RS19390	COG0747	negative chemotaxis
I3J08_RS19395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS19400	COG0601	transmembrane transport
I3J08_RS19455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J08_RS19495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J08_RS19535	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J08_RS19545	COG1615	UPF0182 protein
I3J08_RS19570	COG0753	catalase activity
I3J08_RS19580	COG0483	inositol monophosphate 1-phosphatase activity
I3J08_RS19590	COG2076	Multidrug Resistance protein
I3J08_RS19600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J08_RS19610	COG2135	peptidase activity
I3J08_RS19620	COG1595	DNA-templated transcription, initiation
I3J08_RS19625	COG5662	AntiSigma factor
I3J08_RS19645	COG0242	peptide deformylase activity
I3J08_RS19670	COG2188	Transcriptional regulator
I3J08_RS19675	COG2182	Extracellular solute-binding protein
I3J08_RS19680	COG1175	transmembrane transport
I3J08_RS19685	COG0395	ABC-type sugar transport system, permease component
I3J08_RS19690	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J08_RS19695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J08_RS19710	COG1597	lipid kinase activity
I3J08_RS19745	COG0142	geranyltranstransferase activity
I3J08_RS19765	COG5640	endopeptidase activity
I3J08_RS19775	COG0494	nUDIX hydrolase
I3J08_RS19795	COG4106	trans-aconitate 2-methyltransferase activity
I3J08_RS19800	COG1126	abc transporter atp-binding protein
I3J08_RS19820	COG0604	alcohol dehydrogenase
I3J08_RS19855	COG2255	four-way junction helicase activity
I3J08_RS19865	COG0567	Dehydrogenase, E1 component
I3J08_RS19865	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J08_RS19870	COG2205	protein histidine kinase activity
I3J08_RS19875	COG0745	RESPONSE REGULATOR receiver
I3J08_RS19885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J08_RS19890	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J08_RS19910	COG2205	protein histidine kinase activity
I3J08_RS19945	COG2318	DinB family
I3J08_RS19975	COG0768	penicillin binding
I3J08_RS20030	COG1793	dna ligase
I3J08_RS20035	COG3285	dna ligase
I3J08_RS20035	COG1793	dna ligase
I3J08_RS20040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J08_RS20045	COG2072	flavoprotein involved in K transport
I3J08_RS20065	COG0745	RESPONSE REGULATOR receiver
I3J08_RS20070	COG2205	protein histidine kinase activity
I3J08_RS20080	COG2124	cytochrome p450
I3J08_RS20085	COG0768	penicillin binding
I3J08_RS20090	COG0768	penicillin binding
I3J08_RS20095	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J08_RS20105	COG0747	negative chemotaxis
I3J08_RS20110	COG0456	acetyltransferase
I3J08_RS20115	COG0697	spore germination
I3J08_RS20155	COG2175	clavaminate synthase activity
I3J08_RS20160	COG0010	Belongs to the arginase family
I3J08_RS20165	COG0367	asparagine synthase
I3J08_RS20175	COG0768	penicillin binding
I3J08_RS20185	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J08_RS20195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J08_RS20205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J08_RS20215	COG2192	nodulation
I3J08_RS20235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J08_RS20240	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J08_RS20245	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS20255	COG1686	Belongs to the peptidase S11 family
I3J08_RS20260	COG2367	Beta-lactamase
I3J08_RS20400	COG0018	arginyl-trna synthetase
I3J08_RS20405	COG0019	diaminopimelate decarboxylase activity
I3J08_RS20410	COG0460	homoserine dehydrogenase
I3J08_RS20415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J08_RS20420	COG0083	homoserine kinase activity
I3J08_RS20435	COG1316	TRANSCRIPTIONal
I3J08_RS20440	COG0254	rRNA binding
I3J08_RS20445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J08_RS20450	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J08_RS20460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J08_RS20465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J08_RS20485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J08_RS20490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J08_RS20495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J08_RS20500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J08_RS20505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J08_RS20510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J08_RS20515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J08_RS20530	COG0494	nUDIX hydrolase
I3J08_RS20540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J08_RS20570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J08_RS20590	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J08_RS20600	COG2197	response regulator
I3J08_RS20605	COG4585	Histidine kinase
I3J08_RS20620	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J08_RS20635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J08_RS20670	COG1131	(ABC) transporter
I3J08_RS20690	COG0183	Belongs to the thiolase family
I3J08_RS20705	COG0745	RESPONSE REGULATOR receiver
I3J08_RS20750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS20750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS20785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J08_RS20790	COG0857	belongs to the CobB CobQ family
I3J08_RS20790	COG0280	phosphate acetyltransferase
I3J08_RS20795	COG0205	6-phosphofructokinase activity
I3J08_RS20805	COG1175	transmembrane transport
I3J08_RS20835	COG0181	hydroxymethylbilane synthase activity
I3J08_RS20840	COG4565	transcriptional regulatory protein
I3J08_RS20845	COG3290	protein histidine kinase activity
I3J08_RS20850	COG1301	dicarboxylic acid transport
I3J08_RS20865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J08_RS20875	COG0366	Alpha amylase catalytic
I3J08_RS20880	COG0366	Alpha amylase catalytic
I3J08_RS20885	COG0058	SHG alpha-glucan phosphorylase activity
I3J08_RS20895	COG4585	Histidine kinase
I3J08_RS20900	COG2197	response regulator
I3J08_RS20935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J08_RS20945	COG1132	(ABC) transporter
I3J08_RS20950	COG1132	(ABC) transporter
I3J08_RS20965	COG1024	Enoyl-CoA hydratase
I3J08_RS21095	COG2856	Zn peptidase
I3J08_RS21105	COG1760	l-serine dehydratase
I3J08_RS21110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J08_RS21115	COG0509	glycine decarboxylation via glycine cleavage system
I3J08_RS21120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J08_RS21140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS21145	COG0747	negative chemotaxis
I3J08_RS21150	COG0601	transmembrane transport
I3J08_RS21155	COG0444	Belongs to the ABC transporter superfamily
I3J08_RS21160	COG4608	Belongs to the ABC transporter superfamily
I3J08_RS21165	COG2860	membrane
I3J08_RS21190	COG0482	sulfurtransferase activity
I3J08_RS21200	COG1611	Belongs to the LOG family
I3J08_RS21205	COG4221	oxidoreductase activity
I3J08_RS21215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J08_RS21225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J08_RS21230	COG0154	amidase activity
I3J08_RS21240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J08_RS21250	COG2409	Drug exporters of the RND superfamily
I3J08_RS21255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J08_RS21270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J08_RS21270	COG1672	PFAM Archaeal ATPase
I3J08_RS21280	COG2133	pyrroloquinoline quinone binding
I3J08_RS21285	COG0667	Aldo Keto reductase
I3J08_RS21305	COG0440	acetolactate synthase activity
I3J08_RS21310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J08_RS21315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J08_RS21320	COG2508	Transcriptional regulator
I3J08_RS21320	COG2508	Transcriptional regulator
I3J08_RS21325	COG0506	proline dehydrogenase activity
I3J08_RS21330	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS21335	COG0640	Transcriptional regulator
I3J08_RS21395	COG1082	Xylose isomerase domain protein TIM barrel
I3J08_RS21410	COG0473	3-isopropylmalate dehydrogenase activity
I3J08_RS21415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J08_RS21430	COG3321	synthase
I3J08_RS21430	COG0604	alcohol dehydrogenase
I3J08_RS21440	COG0300	oxidoreductase activity
I3J08_RS21465	COG0831	urea catabolic process
I3J08_RS21465	COG0832	Belongs to the urease beta subunit family
I3J08_RS21475	COG0804	urea catabolic process
I3J08_RS21480	COG2957	Belongs to the agmatine deiminase family
I3J08_RS21490	COG0477	Major facilitator Superfamily
I3J08_RS21495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J08_RS21505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J08_RS21525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J08_RS21545	COG2018	Roadblock/LC7 domain
I3J08_RS21565	COG2018	Roadblock/LC7 domain
I3J08_RS21570	COG5002	protein histidine kinase activity
I3J08_RS21580	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J08_RS21585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J08_RS21590	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J08_RS21620	COG1414	Transcriptional regulator
I3J08_RS21625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J08_RS21630	COG0066	3-isopropylmalate dehydratase activity
I3J08_RS21640	COG0776	regulation of translation
I3J08_RS21650	COG1920	GTP binding
I3J08_RS21660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J08_RS21665	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J08_RS21680	COG0351	phosphomethylpyrimidine kinase
I3J08_RS21685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J08_RS21690	COG1461	Dihydroxyacetone kinase
I3J08_RS21700	COG0742	ribosomal rna small subunit methyltransferase
I3J08_RS21705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J08_RS21720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J08_RS21725	COG0571	ribonuclease III activity
I3J08_RS21730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J08_RS21735	COG2340	Cysteine-rich secretory protein family
I3J08_RS21740	COG1254	Belongs to the acylphosphatase family
I3J08_RS21755	COG1196	nuclear chromosome segregation
I3J08_RS21760	COG0477	Major facilitator Superfamily
I3J08_RS21765	COG4552	Acetyltransferase involved in intracellular survival and related
I3J08_RS21795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J08_RS21805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J08_RS21815	COG0228	four-way junction DNA binding
I3J08_RS21820	COG1837	Belongs to the UPF0109 family
I3J08_RS21825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J08_RS21830	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J08_RS21835	COG0335	large ribosomal subunit rRNA binding
I3J08_RS21840	COG0681	Belongs to the peptidase S26 family
I3J08_RS21855	COG0681	Belongs to the peptidase S26 family
I3J08_RS21865	COG0792	nuclease activity
I3J08_RS21880	COG1191	sigma factor activity
I3J08_RS21895	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J08_RS21900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J08_RS21905	COG0528	UMP kinase activity
I3J08_RS21910	COG0233	cytoplasmic translational termination
I3J08_RS21915	COG0575	Belongs to the CDS family
I3J08_RS21920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J08_RS21935	COG3842	ATPase activity
I3J08_RS21950	COG1136	(ABC) transporter
I3J08_RS21955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS21965	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS21980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J08_RS22005	COG3842	ATPase activity
I3J08_RS22010	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J08_RS22015	COG1177	transmembrane transport
I3J08_RS22020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J08_RS22050	COG2508	Transcriptional regulator
I3J08_RS22065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J08_RS22070	COG0750	zinc metalloprotease
I3J08_RS22075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J08_RS22090	COG0442	prolyl-tRNA aminoacylation
I3J08_RS22110	COG0779	Required for maturation of 30S ribosomal subunits
I3J08_RS22125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J08_RS22135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J08_RS22140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J08_RS22160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS22165	COG0601	transmembrane transport
I3J08_RS22170	COG0747	negative chemotaxis
I3J08_RS22175	COG0455	bacterial-type flagellum organization
I3J08_RS22195	COG3266	domain, Protein
I3J08_RS22200	COG1404	Belongs to the peptidase S8 family
I3J08_RS22215	COG1404	Belongs to the peptidase S8 family
I3J08_RS22230	COG1674	ftsk spoiiie
I3J08_RS22240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J08_RS22245	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J08_RS22250	COG0612	Peptidase, M16
I3J08_RS22255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J08_RS22275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J08_RS22280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J08_RS22285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J08_RS22310	COG2770	Histidine kinase
I3J08_RS22310	COG2208	phosphoserine phosphatase activity
I3J08_RS22315	COG0784	Response regulator, receiver
I3J08_RS22315	COG5002	protein histidine kinase activity
I3J08_RS22325	COG1674	ftsk spoiiie
I3J08_RS22335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J08_RS22345	COG1546	Belongs to the CinA family
I3J08_RS22345	COG1058	Belongs to the CinA family
I3J08_RS22350	COG1396	sequence-specific DNA binding
I3J08_RS22355	COG0783	Belongs to the Dps family
I3J08_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS22365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J08_RS22370	COG1201	RNA secondary structure unwinding
I3J08_RS22410	COG2137	regulation of response to DNA damage stimulus
I3J08_RS22425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J08_RS22430	COG0765	amino acid transport
I3J08_RS22435	COG0765	amino acid transport
I3J08_RS22440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J08_RS22445	COG1126	abc transporter atp-binding protein
I3J08_RS22450	COG0745	RESPONSE REGULATOR receiver
I3J08_RS22455	COG2205	protein histidine kinase activity
I3J08_RS22460	COG2358	TRAP transporter, solute receptor (TAXI family
I3J08_RS22465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J08_RS22485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J08_RS22495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J08_RS22500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J08_RS22510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J08_RS22540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J08_RS22545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J08_RS22550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J08_RS22575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J08_RS22605	COG1131	(ABC) transporter
I3J08_RS22610	COG2186	Transcriptional regulator
I3J08_RS22615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J08_RS22630	COG0187	DNA topoisomerase II activity
I3J08_RS22635	COG4565	transcriptional regulatory protein
I3J08_RS22640	COG3290	protein histidine kinase activity
I3J08_RS22650	COG0372	Belongs to the citrate synthase family
I3J08_RS22660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J08_RS22665	COG0612	Peptidase, M16
I3J08_RS22675	COG0739	heme binding
I3J08_RS22675	COG0741	lytic transglycosylase activity
I3J08_RS22675	COG1196	nuclear chromosome segregation
I3J08_RS22680	COG1802	Transcriptional regulator
I3J08_RS22685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J08_RS22690	COG1042	CoA-binding domain protein
I3J08_RS22690	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J08_RS22690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J08_RS22705	COG1435	thymidine kinase activity
I3J08_RS22720	COG0702	epimerase
I3J08_RS22730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J08_RS22745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J08_RS22750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS22755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J08_RS22815	COG2264	protein methyltransferase activity
I3J08_RS22825	COG3903	Transcriptional regulator
I3J08_RS22825	COG3629	intracellular signal transduction
I3J08_RS22845	COG2409	Drug exporters of the RND superfamily
I3J08_RS22900	COG0142	geranyltranstransferase activity
I3J08_RS22930	COG0494	nUDIX hydrolase
I3J08_RS22945	COG2264	protein methyltransferase activity
I3J08_RS22950	COG0483	inositol monophosphate 1-phosphatase activity
I3J08_RS22960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J08_RS22965	COG0531	amino acid
I3J08_RS22970	COG0569	domain protein
I3J08_RS22980	COG1136	(ABC) transporter
I3J08_RS22980	COG0577	efflux transmembrane transporter activity
I3J08_RS23015	COG1136	(ABC) transporter
I3J08_RS23015	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J08_RS23025	COG0756	dUTP diphosphatase activity
I3J08_RS23050	COG2205	protein histidine kinase activity
I3J08_RS23055	COG0745	RESPONSE REGULATOR receiver
I3J08_RS23070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J08_RS23100	COG4689	acetoacetate decarboxylase
I3J08_RS23120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J08_RS23140	COG1799	cell septum assembly
I3J08_RS23160	COG2040	homocysteine
I3J08_RS23180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J08_RS23190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J08_RS23195	COG1024	Enoyl-CoA hydratase
I3J08_RS23240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J08_RS23260	COG1522	sequence-specific DNA binding
I3J08_RS23265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J08_RS23275	COG1653	transport
I3J08_RS23280	COG1175	transmembrane transport
I3J08_RS23285	COG0395	ABC-type sugar transport system, permease component
I3J08_RS23290	COG1940	carbohydrate kinase activity
I3J08_RS23295	COG4213	ABC transporter substrate-binding protein
I3J08_RS23305	COG4214	carbohydrate transport
I3J08_RS23310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J08_RS23315	COG0531	amino acid
I3J08_RS23325	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J08_RS23325	COG1024	Enoyl-CoA hydratase
I3J08_RS23330	COG0183	Belongs to the thiolase family
I3J08_RS23350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J08_RS23355	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J08_RS23365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J08_RS23370	COG3253	May function as heme-dependent peroxidase
I3J08_RS23375	COG0596	Alpha beta hydrolase
I3J08_RS23390	COG3220	belongs to the UPF0276 family
I3J08_RS23410	COG1846	Transcriptional regulator
I3J08_RS23415	COG1764	response to oxidative stress
I3J08_RS23440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J08_RS23445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J08_RS23520	COG1175	transmembrane transport
I3J08_RS23555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J08_RS23560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J08_RS23580	COG0529	Catalyzes the synthesis of activated sulfate
I3J08_RS23585	COG0175	sulfate reduction
I3J08_RS23605	COG3284	Transcriptional regulator
I3J08_RS23610	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS23650	COG3290	protein histidine kinase activity
I3J08_RS23680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J08_RS23705	COG1162	GTPase activity
I3J08_RS23735	COG0028	Belongs to the TPP enzyme family
I3J08_RS23755	COG1802	Transcriptional regulator
I3J08_RS23770	COG3842	ATPase activity
I3J08_RS23780	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J08_RS23785	COG3835	regulator
I3J08_RS23800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J08_RS23845	COG1609	Transcriptional regulator
I3J08_RS23855	COG0515	serine threonine protein kinase
I3J08_RS23865	COG1132	(ABC) transporter
I3J08_RS23870	COG1132	(ABC) transporter
I3J08_RS23875	COG2197	response regulator
I3J08_RS23890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS23905	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS23910	COG2345	Transcriptional regulator
I3J08_RS23925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J08_RS23960	COG0243	molybdopterin cofactor binding
I3J08_RS23975	COG1404	Belongs to the peptidase S8 family
I3J08_RS23995	COG3409	Peptidoglycan-binding domain 1 protein
I3J08_RS24010	COG2197	response regulator
I3J08_RS24015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J08_RS24020	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS24045	COG2351	hydroxyisourate hydrolase activity
I3J08_RS24075	COG1288	antiporter activity
I3J08_RS24090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J08_RS24100	COG0746	molybdenum cofactor guanylyltransferase activity
I3J08_RS24115	COG1414	Transcriptional regulator
I3J08_RS24120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J08_RS24125	COG4266	Belongs to the allantoicase family
I3J08_RS24140	COG4585	Histidine kinase
I3J08_RS24145	COG2197	response regulator
I3J08_RS24155	COG0673	inositol 2-dehydrogenase activity
I3J08_RS24160	COG2188	Transcriptional regulator
I3J08_RS24180	COG1940	carbohydrate kinase activity
I3J08_RS24190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J08_RS24210	COG1126	abc transporter atp-binding protein
I3J08_RS24215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J08_RS24220	COG0765	amino acid transport
I3J08_RS24225	COG0765	amino acid transport
I3J08_RS24235	COG0405	Gamma-glutamyltransferase
I3J08_RS24265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J08_RS24270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J08_RS24280	COG0095	Lipoate-protein ligase
I3J08_RS24285	COG0483	inositol monophosphate 1-phosphatase activity
I3J08_RS24300	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J08_RS24310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J08_RS24315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J08_RS24330	COG1929	Belongs to the glycerate kinase type-1 family
I3J08_RS24340	COG0688	phosphatidylethanolamine metabolic process
I3J08_RS24345	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS24360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS24360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J08_RS24365	COG0604	alcohol dehydrogenase
I3J08_RS24420	COG2362	D-Aminopeptidase
I3J08_RS24425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J08_RS24435	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J08_RS24440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J08_RS24510	COG1063	alcohol dehydrogenase
I3J08_RS24560	COG1793	dna ligase
I3J08_RS24570	COG0656	L-ascorbic acid biosynthetic process
I3J08_RS24580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J08_RS24585	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J08_RS24600	COG3250	beta-galactosidase activity
I3J08_RS24610	COG3250	beta-galactosidase activity
I3J08_RS24620	COG1595	DNA-templated transcription, initiation
I3J08_RS24640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J08_RS24645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J08_RS24655	COG1940	carbohydrate kinase activity
I3J08_RS24660	COG1129	ABC transporter
I3J08_RS24665	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J08_RS24670	COG4213	ABC transporter substrate-binding protein
I3J08_RS24675	COG0673	inositol 2-dehydrogenase activity
I3J08_RS24790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J08_RS24795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J08_RS24800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J08_RS24815	COG0475	glutathione-regulated potassium exporter activity
I3J08_RS24905	COG3345	alpha-galactosidase
I3J08_RS24910	COG1609	Transcriptional regulator
I3J08_RS24940	COG3012	SEC-C Motif Domain Protein
I3J08_RS24980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J08_RS25035	COG1793	dna ligase
I3J08_RS25075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J08_RS25080	COG0488	(ABC) transporter
I3J08_RS25095	COG1515	deoxyribonuclease V activity
I3J08_RS25100	COG3268	Saccharopine dehydrogenase
I3J08_RS25105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J08_RS25110	COG0183	Belongs to the thiolase family
I3J08_RS25115	COG1024	Enoyl-CoA hydratase
I3J08_RS25115	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J08_RS25135	COG2936	dipeptidyl-peptidase activity
I3J08_RS25145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J08_RS25160	COG2183	response to ionizing radiation
I3J08_RS25190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J08_RS25215	COG0371	Dehydrogenase
I3J08_RS25230	COG1134	teichoic acid transport
I3J08_RS25235	COG1562	ergosterol biosynthetic process
I3J08_RS25245	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J08_RS25255	COG1657	PFAM Prenyltransferase squalene oxidase
I3J08_RS25285	COG2365	Tyrosine phosphatase family
I3J08_RS25295	COG0741	lytic transglycosylase activity
I3J08_RS25295	COG1196	nuclear chromosome segregation
I3J08_RS25295	COG0739	heme binding
I3J08_RS25305	COG1309	transcriptional regulator
I3J08_RS25310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J08_RS25345	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS25350	COG4948	Mandelate Racemase Muconate Lactonizing
I3J08_RS25355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J08_RS25365	COG1116	anion transmembrane transporter activity
I3J08_RS25410	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS25500	COG3511	phospholipase C
I3J08_RS25560	COG2850	peptidyl-arginine hydroxylation
I3J08_RS25565	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS25610	COG0673	inositol 2-dehydrogenase activity
I3J08_RS25650	COG0187	DNA topoisomerase II activity
I3J08_RS25660	COG2226	methyltransferase
I3J08_RS25680	COG0477	Major facilitator Superfamily
I3J08_RS25730	COG4981	capsule polysaccharide biosynthetic process
I3J08_RS25735	COG0500	methyltransferase
I3J08_RS25770	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS25815	COG0247	lactate metabolic process
I3J08_RS25820	COG1139	Iron-sulfur cluster binding protein
I3J08_RS25825	COG1556	Lactate utilization protein
I3J08_RS25850	COG2072	flavoprotein involved in K transport
I3J08_RS25880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J08_RS25935	COG0667	Aldo Keto reductase
I3J08_RS25945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J08_RS25950	COG3251	PFAM MbtH domain protein
I3J08_RS25965	COG2318	DinB family
I3J08_RS25975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J08_RS25980	COG1051	belongs to the nudix hydrolase family
I3J08_RS25995	COG0395	ABC-type sugar transport system, permease component
I3J08_RS26000	COG1175	transmembrane transport
I3J08_RS26045	COG0248	Ppx GppA phosphatase
I3J08_RS26065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J08_RS26095	COG0745	RESPONSE REGULATOR receiver
I3J08_RS26100	COG2205	protein histidine kinase activity
I3J08_RS26135	COG3845	ABC transporter
I3J08_RS26145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J08_RS26155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J08_RS26175	COG0297	glycogen (starch) synthase activity
I3J08_RS26230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J08_RS26245	COG3279	Response regulator of the LytR AlgR family
I3J08_RS26260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J08_RS26265	COG3275	phosphorelay sensor kinase activity
I3J08_RS26310	COG3300	MHYT domain
I3J08_RS26310	COG5001	Diguanylate cyclase
I3J08_RS26330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J08_RS26340	COG3360	Dodecin
I3J08_RS26345	COG2182	Extracellular solute-binding protein
I3J08_RS26350	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J08_RS26355	COG0121	glutamine amidotransferase
I3J08_RS26360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J08_RS26365	COG3572	ergothioneine biosynthetic process
I3J08_RS26380	COG0596	Alpha beta hydrolase
I3J08_RS26385	COG1609	Transcriptional regulator
I3J08_RS26395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J08_RS26400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J08_RS26430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J08_RS26445	COG2205	protein histidine kinase activity
I3J08_RS26450	COG0745	RESPONSE REGULATOR receiver
I3J08_RS26465	COG2755	lipolytic protein G-D-S-L family
I3J08_RS26465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J08_RS26485	COG0579	oxidoreductase
I3J08_RS26490	COG0477	Major facilitator Superfamily
I3J08_RS26495	COG0154	amidase activity
I3J08_RS26500	COG2197	response regulator
I3J08_RS26520	COG4552	Acetyltransferase involved in intracellular survival and related
I3J08_RS26535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J08_RS26540	COG1120	ATPase activity
I3J08_RS26545	COG2207	Transcriptional regulator
I3J08_RS26560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS26570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J08_RS26580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J08_RS26620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J08_RS26640	COG2957	Belongs to the agmatine deiminase family
I3J08_RS26675	COG1174	glycine betaine transport
I3J08_RS26680	COG1174	glycine betaine transport
I3J08_RS26700	COG0477	Major facilitator Superfamily
I3J08_RS26705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J08_RS26745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J08_RS26745	COG0574	Belongs to the PEP-utilizing enzyme family
I3J08_RS26765	COG1597	lipid kinase activity
I3J08_RS26770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J08_RS26775	COG3629	intracellular signal transduction
I3J08_RS26775	COG3903	Transcriptional regulator
I3J08_RS26810	COG1309	transcriptional regulator
I3J08_RS26830	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS26860	COG1131	(ABC) transporter
I3J08_RS26945	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J08_RS26950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J08_RS26985	COG3959	Transketolase, thiamine diphosphate binding domain
I3J08_RS26995	COG3424	synthase
I3J08_RS27005	COG0535	radical SAM domain protein
I3J08_RS27025	COG1376	ErfK ybiS ycfS ynhG family protein
I3J08_RS27030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J08_RS27050	COG0183	Belongs to the thiolase family
I3J08_RS27100	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J08_RS27105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J08_RS27110	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J08_RS27160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J08_RS27165	COG2326	polyphosphate kinase activity
I3J08_RS27195	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS27215	COG1413	lyase activity
I3J08_RS27235	COG0402	S-adenosylhomocysteine deaminase activity
I3J08_RS27250	COG0463	Glycosyl transferase, family 2
I3J08_RS27285	COG2124	cytochrome p450
I3J08_RS27310	COG1024	Enoyl-CoA hydratase
I3J08_RS27310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J08_RS27330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J08_RS27355	COG2124	cytochrome p450
I3J08_RS27370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J08_RS27390	COG1309	transcriptional regulator
I3J08_RS27400	COG1174	glycine betaine transport
I3J08_RS27405	COG1174	glycine betaine transport
I3J08_RS27420	COG3458	cephalosporin-C deacetylase activity
I3J08_RS27425	COG0517	IMP dehydrogenase activity
I3J08_RS27425	COG1125	glycine betaine transport
I3J08_RS27455	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS27460	COG1960	acyl-CoA dehydrogenase activity
I3J08_RS27470	COG0601	transmembrane transport
I3J08_RS27475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J08_RS27480	COG0444	Belongs to the ABC transporter superfamily
I3J08_RS27485	COG1124	(ABC) transporter
I3J08_RS27525	COG2124	cytochrome p450
I3J08_RS27530	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS27580	COG2376	Dihydroxyacetone kinase
I3J08_RS27585	COG2376	Dihydroxyacetone kinase
I3J08_RS27590	COG2130	NADP-dependent
I3J08_RS27595	COG1233	COG1233 Phytoene dehydrogenase and related
I3J08_RS27620	COG1233	COG1233 Phytoene dehydrogenase and related
I3J08_RS27625	COG1653	transport
I3J08_RS27640	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J08_RS27640	COG2172	sigma factor antagonist activity
I3J08_RS27640	COG2208	phosphoserine phosphatase activity
I3J08_RS27645	COG0542	response to heat
I3J08_RS27660	COG1846	Transcriptional regulator
I3J08_RS27705	COG0473	3-isopropylmalate dehydrogenase activity
I3J08_RS27740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J08_RS27745	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS27780	COG0438	transferase activity, transferring glycosyl groups
I3J08_RS27780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J08_RS27790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J08_RS27805	COG4310	Domain of unknown function (DUF2172)
I3J08_RS27815	COG1215	transferase activity, transferring glycosyl groups
I3J08_RS27830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J08_RS27860	COG2124	cytochrome p450
I3J08_RS27875	COG0142	geranyltranstransferase activity
I3J08_RS27880	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS27890	COG0531	amino acid
I3J08_RS27895	COG1012	belongs to the aldehyde dehydrogenase family
I3J08_RS27915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J08_RS27930	COG2018	Roadblock/LC7 domain
I3J08_RS27940	COG0156	8-amino-7-oxononanoate synthase activity
I3J08_RS27945	COG1063	alcohol dehydrogenase
I3J08_RS27970	COG2814	Major facilitator Superfamily
I3J08_RS27995	COG0569	domain protein
I3J08_RS27995	COG0475	glutathione-regulated potassium exporter activity
I3J08_RS28105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J08_RS28150	COG2161	toxin-antitoxin pair type II binding
I3J08_RS28195	COG3547	Transposase (IS116 IS110 IS902 family)
I3J08_RS28205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J08_RS28210	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS28280	COG2197	response regulator
I3J08_RS28310	COG2814	Major facilitator Superfamily
I3J08_RS28315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J08_RS28330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J08_RS28370	COG3321	synthase
I3J08_RS28370	COG0604	alcohol dehydrogenase
I3J08_RS28390	COG2814	Major facilitator Superfamily
I3J08_RS28410	COG0076	glutamate decarboxylase activity
I3J08_RS28445	COG0531	amino acid
I3J08_RS28455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J08_RS28470	COG2304	oxidoreductase activity
I3J08_RS28510	COG2197	response regulator
I3J08_RS28520	COG1222	aaa ATPase
I3J08_RS28530	COG3629	intracellular signal transduction
I3J08_RS28530	COG3903	Transcriptional regulator
I3J08_RS28605	COG2124	cytochrome p450
I3J08_RS28635	COG0789	Transcriptional regulator
I3J08_RS28640	COG0436	Aminotransferase
I3J08_RS28650	COG1695	Transcriptional regulator
I3J08_RS28655	COG2124	cytochrome p450
I3J08_RS28660	COG2124	cytochrome p450
I3J08_RS28665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J08_RS28670	COG0346	lactoylglutathione lyase activity
I3J08_RS28675	COG0640	Transcriptional regulator
I3J08_RS28685	COG2226	methyltransferase
I3J08_RS28695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J08_RS28745	COG0577	efflux transmembrane transporter activity
I3J08_RS28745	COG1136	(ABC) transporter
I3J08_RS28750	COG0577	efflux transmembrane transporter activity
I3J08_RS28750	COG1136	(ABC) transporter
I3J08_RS28765	COG0745	RESPONSE REGULATOR receiver
I3J08_RS28770	COG2205	protein histidine kinase activity
I3J08_RS28800	COG4948	Mandelate Racemase Muconate Lactonizing
I3J08_RS28835	COG2124	cytochrome p450
I3J08_RS28845	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS28955	COG2124	cytochrome p450
I3J08_RS28980	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J08_RS29015	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J08_RS29015	COG2319	Wd-40 repeat
I3J08_RS29020	COG1335	isochorismatase
I3J08_RS29060	COG3409	Peptidoglycan-binding domain 1 protein
I3J08_RS29065	COG3973	AAA domain
I3J08_RS29095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J08_RS29100	COG5183	chlorophyll binding
I3J08_RS29100	COG2133	pyrroloquinoline quinone binding
I3J08_RS29125	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS29135	COG2201	protein-glutamate methylesterase activity
I3J08_RS29150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS29155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J08_RS29160	COG0010	Belongs to the arginase family
I3J08_RS29165	COG0367	asparagine synthase
I3J08_RS29185	COG0436	Aminotransferase
I3J08_RS29190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J08_RS29200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J08_RS29215	COG0583	DNA-binding transcription factor activity
I3J08_RS29260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J08_RS29260	COG2111	Na H antiporter
I3J08_RS29265	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J08_RS29270	COG0651	ATP synthesis coupled electron transport
I3J08_RS29285	COG1320	monovalent cation:proton antiporter activity
I3J08_RS29440	COG3959	Transketolase, thiamine diphosphate binding domain
I3J08_RS29445	COG3958	Transketolase
I3J08_RS29480	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J08_RS29485	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS29490	COG0277	FAD linked oxidase domain protein
I3J08_RS29495	COG1070	Carbohydrate kinase
I3J08_RS29540	COG2124	cytochrome p450
I3J08_RS29550	COG1011	Hydrolase
I3J08_RS29590	COG0789	Transcriptional regulator
I3J08_RS29600	COG3397	chitin binding
I3J08_RS29630	COG1132	(ABC) transporter
I3J08_RS29690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J08_RS29695	COG2124	cytochrome p450
I3J08_RS29710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J08_RS29730	COG3409	Peptidoglycan-binding domain 1 protein
I3J08_RS29730	COG3757	hydrolase, family 25
I3J08_RS29765	COG0488	(ABC) transporter
I3J08_RS29795	COG0698	ribose 5-phosphate isomerase
I3J08_RS29830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J08_RS29840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J08_RS29855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J08_RS29865	COG2267	carboxylic ester hydrolase activity
I3J08_RS29945	COG0477	Major facilitator Superfamily
I3J08_RS29990	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS30025	COG2226	methyltransferase
I3J08_RS30040	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J08_RS30055	COG3409	Peptidoglycan-binding domain 1 protein
I3J08_RS30095	COG0494	nUDIX hydrolase
I3J08_RS30110	COG3903	Transcriptional regulator
I3J08_RS30110	COG3629	intracellular signal transduction
I3J08_RS30135	COG1725	Transcriptional regulator
I3J08_RS30140	COG1131	(ABC) transporter
I3J08_RS30150	COG1309	transcriptional regulator
I3J08_RS30175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J08_RS30225	COG2318	DinB family
I3J08_RS30320	COG2319	Wd-40 repeat
I3J08_RS30320	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J08_RS30350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J08_RS30355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J08_RS30370	COG0431	NADPH-dependent FMN reductase
I3J08_RS30380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS30385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS30390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J08_RS30425	COG0640	Transcriptional regulator
I3J08_RS30445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J08_RS30455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J08_RS30460	COG0301	tRNA thio-modification
I3J08_RS30490	COG1024	Enoyl-CoA hydratase
I3J08_RS30535	COG0110	maltose O-acetyltransferase activity
I3J08_RS30575	COG0477	Major facilitator Superfamily
I3J08_RS30615	COG0546	phosphoglycolate phosphatase activity
I3J08_RS30630	COG0363	glucosamine-6-phosphate deaminase activity
I3J08_RS30635	COG1940	carbohydrate kinase activity
I3J08_RS30660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J08_RS30670	COG4552	Acetyltransferase involved in intracellular survival and related
I3J08_RS30680	COG2816	NAD+ diphosphatase activity
I3J08_RS30690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J08_RS30695	COG1228	amidohydrolase
I3J08_RS30750	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J08_RS30755	COG1732	Glycine betaine
I3J08_RS30760	COG1174	glycine betaine transport
I3J08_RS30765	COG0517	IMP dehydrogenase activity
I3J08_RS30765	COG1125	glycine betaine transport
I3J08_RS30780	COG0076	glutamate decarboxylase activity
I3J08_RS30800	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J08_RS30805	COG1121	(ABC) transporter
I3J08_RS30850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J08_RS30995	COG1320	monovalent cation:proton antiporter activity
I3J08_RS31010	COG0651	ATP synthesis coupled electron transport
I3J08_RS31015	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J08_RS31020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J08_RS31020	COG2111	Na H antiporter
I3J08_RS31070	COG0701	Predicted permease
I3J08_RS31080	COG0515	serine threonine protein kinase
I3J08_RS31080	COG2815	serine threonine protein kinase
I3J08_RS31090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J08_RS31095	COG2070	2-Nitropropane dioxygenase
I3J08_RS31105	COG0387	Pfam Sodium calcium exchanger
I3J08_RS31110	COG2267	carboxylic ester hydrolase activity
I3J08_RS31115	COG0318	PFAM AMP-dependent synthetase and ligase
I3J08_RS31180	COG1132	(ABC) transporter
I3J08_RS31180	COG2375	cellular response to nickel ion
I3J08_RS31195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS31195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J08_RS31205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J08_RS31210	COG0765	amino acid transport
I3J08_RS31215	COG1126	abc transporter atp-binding protein
I3J08_RS31235	COG1957	nucleoside hydrolase
I3J08_RS31245	COG2318	DinB family
I3J08_RS31265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS31270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J08_RS31315	COG0501	Belongs to the peptidase M48B family
I3J08_RS31355	COG1404	Belongs to the peptidase S8 family
I3J08_RS31355	COG4412	M6 family metalloprotease domain protein
I3J08_RS31355	COG4412	M6 family metalloprotease domain protein
I3J08_RS31355	COG1404	Belongs to the peptidase S8 family
I3J08_RS31410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J08_RS31425	COG1028	Short-chain dehydrogenase reductase Sdr
I3J08_RS31460	COG0288	reversible hydration of carbon dioxide
I3J08_RS31470	COG0702	epimerase
I3J08_RS31480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J08_RS31495	COG2226	methyltransferase
I3J08_RS31505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J08_RS31510	COG1937	Protein conserved in bacteria
I3J08_RS31540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J08_RS31605	COG0142	geranyltranstransferase activity
I3J08_RS31615	COG1132	(ABC) transporter
I3J08_RS31625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins