locus-tag	class	description
I3J09_RS00055	COG0475	glutathione-regulated potassium exporter activity
I3J09_RS00055	COG0569	domain protein
I3J09_RS00105	COG1063	alcohol dehydrogenase
I3J09_RS00110	COG0156	8-amino-7-oxononanoate synthase activity
I3J09_RS00120	COG2018	Roadblock/LC7 domain
I3J09_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS00160	COG0531	amino acid
I3J09_RS00170	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS00175	COG0142	geranyltranstransferase activity
I3J09_RS00190	COG2124	cytochrome p450
I3J09_RS00245	COG4310	Domain of unknown function (DUF2172)
I3J09_RS00260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J09_RS00305	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS00310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J09_RS00345	COG0473	3-isopropylmalate dehydrogenase activity
I3J09_RS00390	COG1846	Transcriptional regulator
I3J09_RS00405	COG0542	response to heat
I3J09_RS00410	COG2172	sigma factor antagonist activity
I3J09_RS00410	COG2208	phosphoserine phosphatase activity
I3J09_RS00410	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J09_RS00425	COG1653	transport
I3J09_RS00430	COG1233	COG1233 Phytoene dehydrogenase and related
I3J09_RS00455	COG1233	COG1233 Phytoene dehydrogenase and related
I3J09_RS00460	COG2130	NADP-dependent
I3J09_RS00465	COG2376	Dihydroxyacetone kinase
I3J09_RS00470	COG2376	Dihydroxyacetone kinase
I3J09_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS00525	COG2124	cytochrome p450
I3J09_RS00560	COG1124	(ABC) transporter
I3J09_RS00565	COG0444	Belongs to the ABC transporter superfamily
I3J09_RS00575	COG0601	transmembrane transport
I3J09_RS00585	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS00590	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS00620	COG1125	glycine betaine transport
I3J09_RS00620	COG0517	IMP dehydrogenase activity
I3J09_RS00625	COG3458	cephalosporin-C deacetylase activity
I3J09_RS00640	COG1174	glycine betaine transport
I3J09_RS00645	COG1174	glycine betaine transport
I3J09_RS00655	COG1309	transcriptional regulator
I3J09_RS00690	COG2124	cytochrome p450
I3J09_RS00715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J09_RS00735	COG1024	Enoyl-CoA hydratase
I3J09_RS00735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J09_RS00760	COG2124	cytochrome p450
I3J09_RS00795	COG0463	Glycosyl transferase, family 2
I3J09_RS00810	COG0402	S-adenosylhomocysteine deaminase activity
I3J09_RS00825	COG1413	lyase activity
I3J09_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS00880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J09_RS00930	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J09_RS00935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J09_RS00940	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J09_RS00990	COG0183	Belongs to the thiolase family
I3J09_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J09_RS01015	COG1376	ErfK ybiS ycfS ynhG family protein
I3J09_RS01035	COG0535	radical SAM domain protein
I3J09_RS01045	COG3424	synthase
I3J09_RS01055	COG3959	Transketolase, thiamine diphosphate binding domain
I3J09_RS01090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J09_RS01095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J09_RS01180	COG1131	(ABC) transporter
I3J09_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS01230	COG1309	transcriptional regulator
I3J09_RS01265	COG3629	intracellular signal transduction
I3J09_RS01265	COG3903	Transcriptional regulator
I3J09_RS01270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J09_RS01275	COG1597	lipid kinase activity
I3J09_RS01295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J09_RS01295	COG0574	Belongs to the PEP-utilizing enzyme family
I3J09_RS01335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J09_RS01340	COG0477	Major facilitator Superfamily
I3J09_RS01360	COG1174	glycine betaine transport
I3J09_RS01365	COG1174	glycine betaine transport
I3J09_RS01400	COG2957	Belongs to the agmatine deiminase family
I3J09_RS01420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J09_RS01460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J09_RS01470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J09_RS01480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS01495	COG2207	Transcriptional regulator
I3J09_RS01500	COG1120	ATPase activity
I3J09_RS01505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J09_RS01520	COG4552	Acetyltransferase involved in intracellular survival and related
I3J09_RS01540	COG2197	response regulator
I3J09_RS01545	COG0154	amidase activity
I3J09_RS01550	COG0477	Major facilitator Superfamily
I3J09_RS01555	COG0579	oxidoreductase
I3J09_RS01575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J09_RS01575	COG2755	lipolytic protein G-D-S-L family
I3J09_RS01590	COG0745	RESPONSE REGULATOR receiver
I3J09_RS01595	COG2205	protein histidine kinase activity
I3J09_RS01610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J09_RS01640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J09_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J09_RS01655	COG1609	Transcriptional regulator
I3J09_RS01660	COG0596	Alpha beta hydrolase
I3J09_RS01675	COG3572	ergothioneine biosynthetic process
I3J09_RS01680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J09_RS01685	COG0121	glutamine amidotransferase
I3J09_RS01690	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J09_RS01695	COG2182	Extracellular solute-binding protein
I3J09_RS01700	COG3360	Dodecin
I3J09_RS01710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J09_RS01730	COG5001	Diguanylate cyclase
I3J09_RS01730	COG3300	MHYT domain
I3J09_RS01775	COG3275	phosphorelay sensor kinase activity
I3J09_RS01780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J09_RS01795	COG3279	Response regulator of the LytR AlgR family
I3J09_RS01810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J09_RS01865	COG0297	glycogen (starch) synthase activity
I3J09_RS01885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J09_RS01895	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J09_RS01905	COG3845	ABC transporter
I3J09_RS01940	COG2205	protein histidine kinase activity
I3J09_RS01945	COG0745	RESPONSE REGULATOR receiver
I3J09_RS01975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J09_RS01995	COG0248	Ppx GppA phosphatase
I3J09_RS02040	COG1175	transmembrane transport
I3J09_RS02045	COG0395	ABC-type sugar transport system, permease component
I3J09_RS02060	COG1051	belongs to the nudix hydrolase family
I3J09_RS02065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J09_RS02075	COG2318	DinB family
I3J09_RS02090	COG3251	PFAM MbtH domain protein
I3J09_RS02095	COG3320	Male sterility
I3J09_RS02095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J09_RS02120	COG0667	Aldo Keto reductase
I3J09_RS02175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J09_RS02180	COG0842	Transport permease protein
I3J09_RS02180	COG1129	ABC transporter
I3J09_RS02205	COG2072	flavoprotein involved in K transport
I3J09_RS02230	COG1556	Lactate utilization protein
I3J09_RS02235	COG1139	Iron-sulfur cluster binding protein
I3J09_RS02240	COG0247	lactate metabolic process
I3J09_RS02285	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS02320	COG0500	methyltransferase
I3J09_RS02325	COG4981	capsule polysaccharide biosynthetic process
I3J09_RS02375	COG0477	Major facilitator Superfamily
I3J09_RS02395	COG2226	methyltransferase
I3J09_RS02405	COG0187	DNA topoisomerase II activity
I3J09_RS02445	COG0673	inositol 2-dehydrogenase activity
I3J09_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS02495	COG2850	peptidyl-arginine hydroxylation
I3J09_RS02555	COG3511	phospholipase C
I3J09_RS02645	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS02690	COG1116	anion transmembrane transporter activity
I3J09_RS02700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J09_RS02705	COG4948	Mandelate Racemase Muconate Lactonizing
I3J09_RS02710	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS02745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J09_RS02750	COG1309	transcriptional regulator
I3J09_RS02760	COG0741	lytic transglycosylase activity
I3J09_RS02760	COG1196	nuclear chromosome segregation
I3J09_RS02760	COG0739	heme binding
I3J09_RS02770	COG2365	Tyrosine phosphatase family
I3J09_RS02800	COG1657	PFAM Prenyltransferase squalene oxidase
I3J09_RS02810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J09_RS02820	COG1562	ergosterol biosynthetic process
I3J09_RS02825	COG1134	teichoic acid transport
I3J09_RS02840	COG0371	Dehydrogenase
I3J09_RS02865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J09_RS02895	COG2183	response to ionizing radiation
I3J09_RS02910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J09_RS02920	COG2936	dipeptidyl-peptidase activity
I3J09_RS02940	COG1024	Enoyl-CoA hydratase
I3J09_RS02940	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J09_RS02945	COG0183	Belongs to the thiolase family
I3J09_RS02950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J09_RS02955	COG3268	Saccharopine dehydrogenase
I3J09_RS02960	COG1515	deoxyribonuclease V activity
I3J09_RS02975	COG0488	(ABC) transporter
I3J09_RS02980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J09_RS03020	COG1793	dna ligase
I3J09_RS03075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J09_RS03115	COG3012	SEC-C Motif Domain Protein
I3J09_RS03145	COG1609	Transcriptional regulator
I3J09_RS03150	COG3345	alpha-galactosidase
I3J09_RS03240	COG0475	glutathione-regulated potassium exporter activity
I3J09_RS03255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J09_RS03260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J09_RS03265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J09_RS03355	COG1082	Xylose isomerase domain protein TIM barrel
I3J09_RS03380	COG0673	inositol 2-dehydrogenase activity
I3J09_RS03385	COG4213	ABC transporter substrate-binding protein
I3J09_RS03390	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J09_RS03395	COG1129	ABC transporter
I3J09_RS03400	COG1940	carbohydrate kinase activity
I3J09_RS03410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J09_RS03415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J09_RS03435	COG1595	DNA-templated transcription, initiation
I3J09_RS03445	COG3250	beta-galactosidase activity
I3J09_RS03455	COG3250	beta-galactosidase activity
I3J09_RS03470	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J09_RS03475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J09_RS03485	COG0656	L-ascorbic acid biosynthetic process
I3J09_RS03495	COG1793	dna ligase
I3J09_RS03545	COG1063	alcohol dehydrogenase
I3J09_RS03615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J09_RS03620	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J09_RS03630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J09_RS03635	COG2362	D-Aminopeptidase
I3J09_RS03690	COG0604	alcohol dehydrogenase
I3J09_RS03695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS03695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS03710	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS03715	COG0688	phosphatidylethanolamine metabolic process
I3J09_RS03725	COG1929	Belongs to the glycerate kinase type-1 family
I3J09_RS03740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J09_RS03745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J09_RS03755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J09_RS03770	COG0483	inositol monophosphate 1-phosphatase activity
I3J09_RS03775	COG0095	Lipoate-protein ligase
I3J09_RS03785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J09_RS03790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J09_RS03820	COG0405	Gamma-glutamyltransferase
I3J09_RS03830	COG0765	amino acid transport
I3J09_RS03835	COG0765	amino acid transport
I3J09_RS03840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J09_RS03845	COG1126	abc transporter atp-binding protein
I3J09_RS03865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J09_RS03875	COG1940	carbohydrate kinase activity
I3J09_RS03895	COG2188	Transcriptional regulator
I3J09_RS03900	COG0673	inositol 2-dehydrogenase activity
I3J09_RS03910	COG2197	response regulator
I3J09_RS03915	COG4585	Histidine kinase
I3J09_RS03930	COG4266	Belongs to the allantoicase family
I3J09_RS03935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J09_RS03940	COG1414	Transcriptional regulator
I3J09_RS03955	COG0746	molybdenum cofactor guanylyltransferase activity
I3J09_RS03965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J09_RS03980	COG1288	antiporter activity
I3J09_RS04010	COG2351	hydroxyisourate hydrolase activity
I3J09_RS04035	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS04040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J09_RS04045	COG2197	response regulator
I3J09_RS04060	COG3409	Peptidoglycan-binding domain 1 protein
I3J09_RS04080	COG1404	Belongs to the peptidase S8 family
I3J09_RS04095	COG0243	molybdopterin cofactor binding
I3J09_RS04130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J09_RS04145	COG2345	Transcriptional regulator
I3J09_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS04165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS04180	COG2197	response regulator
I3J09_RS04185	COG1132	(ABC) transporter
I3J09_RS04190	COG1132	(ABC) transporter
I3J09_RS04200	COG0515	serine threonine protein kinase
I3J09_RS04210	COG1609	Transcriptional regulator
I3J09_RS04255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J09_RS04270	COG3835	regulator
I3J09_RS04275	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J09_RS04285	COG3842	ATPase activity
I3J09_RS04300	COG1802	Transcriptional regulator
I3J09_RS04320	COG0028	Belongs to the TPP enzyme family
I3J09_RS04350	COG1162	GTPase activity
I3J09_RS04375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J09_RS04405	COG3290	protein histidine kinase activity
I3J09_RS04445	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS04450	COG3284	Transcriptional regulator
I3J09_RS04470	COG0175	sulfate reduction
I3J09_RS04475	COG0529	Catalyzes the synthesis of activated sulfate
I3J09_RS04495	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J09_RS04500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J09_RS04535	COG1175	transmembrane transport
I3J09_RS04610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J09_RS04615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J09_RS04640	COG1764	response to oxidative stress
I3J09_RS04645	COG1846	Transcriptional regulator
I3J09_RS04665	COG3220	belongs to the UPF0276 family
I3J09_RS04680	COG0596	Alpha beta hydrolase
I3J09_RS04685	COG3253	May function as heme-dependent peroxidase
I3J09_RS04690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J09_RS04700	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J09_RS04705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J09_RS04725	COG0183	Belongs to the thiolase family
I3J09_RS04730	COG1024	Enoyl-CoA hydratase
I3J09_RS04730	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J09_RS04740	COG0531	amino acid
I3J09_RS04745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J09_RS04750	COG4214	carbohydrate transport
I3J09_RS04760	COG4213	ABC transporter substrate-binding protein
I3J09_RS04765	COG1940	carbohydrate kinase activity
I3J09_RS04770	COG0395	ABC-type sugar transport system, permease component
I3J09_RS04775	COG1175	transmembrane transport
I3J09_RS04780	COG1653	transport
I3J09_RS04790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J09_RS04795	COG1522	sequence-specific DNA binding
I3J09_RS04815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J09_RS04860	COG1024	Enoyl-CoA hydratase
I3J09_RS04865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J09_RS04875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J09_RS04895	COG2040	homocysteine
I3J09_RS04915	COG1799	cell septum assembly
I3J09_RS04935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J09_RS04955	COG4689	acetoacetate decarboxylase
I3J09_RS04985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J09_RS05000	COG0745	RESPONSE REGULATOR receiver
I3J09_RS05005	COG2205	protein histidine kinase activity
I3J09_RS05030	COG0756	dUTP diphosphatase activity
I3J09_RS05040	COG1136	(ABC) transporter
I3J09_RS05040	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J09_RS05075	COG0577	efflux transmembrane transporter activity
I3J09_RS05075	COG1136	(ABC) transporter
I3J09_RS05085	COG0569	domain protein
I3J09_RS05090	COG0531	amino acid
I3J09_RS05095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J09_RS05105	COG0483	inositol monophosphate 1-phosphatase activity
I3J09_RS05110	COG2264	protein methyltransferase activity
I3J09_RS05125	COG0494	nUDIX hydrolase
I3J09_RS05155	COG0142	geranyltranstransferase activity
I3J09_RS05210	COG2409	Drug exporters of the RND superfamily
I3J09_RS05230	COG3629	intracellular signal transduction
I3J09_RS05230	COG3903	Transcriptional regulator
I3J09_RS05240	COG2264	protein methyltransferase activity
I3J09_RS05300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J09_RS05305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS05310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J09_RS05325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J09_RS05335	COG0702	epimerase
I3J09_RS05350	COG1435	thymidine kinase activity
I3J09_RS05365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J09_RS05365	COG1042	CoA-binding domain protein
I3J09_RS05365	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J09_RS05370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J09_RS05375	COG1802	Transcriptional regulator
I3J09_RS05380	COG0739	heme binding
I3J09_RS05380	COG1196	nuclear chromosome segregation
I3J09_RS05380	COG0741	lytic transglycosylase activity
I3J09_RS05390	COG0612	Peptidase, M16
I3J09_RS05395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J09_RS05405	COG0372	Belongs to the citrate synthase family
I3J09_RS05415	COG3290	protein histidine kinase activity
I3J09_RS05420	COG4565	transcriptional regulatory protein
I3J09_RS05425	COG0187	DNA topoisomerase II activity
I3J09_RS05440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J09_RS05445	COG2186	Transcriptional regulator
I3J09_RS05450	COG1131	(ABC) transporter
I3J09_RS05480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J09_RS05505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J09_RS05510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J09_RS05515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J09_RS05545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J09_RS05555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J09_RS05560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J09_RS05570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J09_RS05590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J09_RS05595	COG2358	TRAP transporter, solute receptor (TAXI family
I3J09_RS05600	COG2205	protein histidine kinase activity
I3J09_RS05605	COG0745	RESPONSE REGULATOR receiver
I3J09_RS05610	COG1126	abc transporter atp-binding protein
I3J09_RS05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J09_RS05620	COG0765	amino acid transport
I3J09_RS05625	COG0765	amino acid transport
I3J09_RS05630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J09_RS05645	COG2137	regulation of response to DNA damage stimulus
I3J09_RS05685	COG1201	RNA secondary structure unwinding
I3J09_RS05690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J09_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS05700	COG0783	Belongs to the Dps family
I3J09_RS05705	COG1396	sequence-specific DNA binding
I3J09_RS05710	COG1546	Belongs to the CinA family
I3J09_RS05710	COG1058	Belongs to the CinA family
I3J09_RS05720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J09_RS05730	COG1674	ftsk spoiiie
I3J09_RS05740	COG5002	protein histidine kinase activity
I3J09_RS05740	COG0784	Response regulator, receiver
I3J09_RS05745	COG2208	phosphoserine phosphatase activity
I3J09_RS05745	COG2770	Histidine kinase
I3J09_RS05770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J09_RS05775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J09_RS05780	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J09_RS05800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J09_RS05805	COG0612	Peptidase, M16
I3J09_RS05810	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J09_RS05815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J09_RS05825	COG1674	ftsk spoiiie
I3J09_RS05840	COG1404	Belongs to the peptidase S8 family
I3J09_RS05855	COG1404	Belongs to the peptidase S8 family
I3J09_RS05860	COG3266	domain, Protein
I3J09_RS05880	COG0455	bacterial-type flagellum organization
I3J09_RS05885	COG0747	negative chemotaxis
I3J09_RS05890	COG0601	transmembrane transport
I3J09_RS05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J09_RS05915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J09_RS05920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J09_RS05930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J09_RS05945	COG0779	Required for maturation of 30S ribosomal subunits
I3J09_RS05965	COG0442	prolyl-tRNA aminoacylation
I3J09_RS05980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J09_RS05985	COG0750	zinc metalloprotease
I3J09_RS05990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J09_RS06005	COG2508	Transcriptional regulator
I3J09_RS06035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J09_RS06040	COG1177	transmembrane transport
I3J09_RS06045	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J09_RS06050	COG3842	ATPase activity
I3J09_RS06075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J09_RS06090	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS06100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS06105	COG1136	(ABC) transporter
I3J09_RS06120	COG3842	ATPase activity
I3J09_RS06135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J09_RS06140	COG0575	Belongs to the CDS family
I3J09_RS06145	COG0233	cytoplasmic translational termination
I3J09_RS06150	COG0528	UMP kinase activity
I3J09_RS06155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J09_RS06160	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J09_RS06175	COG1191	sigma factor activity
I3J09_RS06190	COG0792	nuclease activity
I3J09_RS06200	COG0681	Belongs to the peptidase S26 family
I3J09_RS06215	COG0681	Belongs to the peptidase S26 family
I3J09_RS06220	COG0335	large ribosomal subunit rRNA binding
I3J09_RS06225	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J09_RS06230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J09_RS06235	COG1837	Belongs to the UPF0109 family
I3J09_RS06240	COG0228	four-way junction DNA binding
I3J09_RS06250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J09_RS06260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J09_RS06290	COG4552	Acetyltransferase involved in intracellular survival and related
I3J09_RS06295	COG0477	Major facilitator Superfamily
I3J09_RS06300	COG1196	nuclear chromosome segregation
I3J09_RS06315	COG1254	Belongs to the acylphosphatase family
I3J09_RS06320	COG2340	Cysteine-rich secretory protein family
I3J09_RS06325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J09_RS06330	COG0571	ribonuclease III activity
I3J09_RS06335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J09_RS06350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J09_RS06355	COG0742	ribosomal rna small subunit methyltransferase
I3J09_RS06365	COG1461	Dihydroxyacetone kinase
I3J09_RS06370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J09_RS06375	COG0351	phosphomethylpyrimidine kinase
I3J09_RS06390	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J09_RS06395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J09_RS06405	COG1920	GTP binding
I3J09_RS06415	COG0776	regulation of translation
I3J09_RS06425	COG0066	3-isopropylmalate dehydratase activity
I3J09_RS06430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J09_RS06435	COG1414	Transcriptional regulator
I3J09_RS06465	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J09_RS06470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J09_RS06475	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J09_RS06485	COG5002	protein histidine kinase activity
I3J09_RS06490	COG2018	Roadblock/LC7 domain
I3J09_RS06510	COG2018	Roadblock/LC7 domain
I3J09_RS06530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J09_RS06550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J09_RS06560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J09_RS06565	COG0477	Major facilitator Superfamily
I3J09_RS06575	COG2957	Belongs to the agmatine deiminase family
I3J09_RS06580	COG0804	urea catabolic process
I3J09_RS06590	COG0832	Belongs to the urease beta subunit family
I3J09_RS06590	COG0831	urea catabolic process
I3J09_RS06615	COG0300	oxidoreductase activity
I3J09_RS06625	COG3321	synthase
I3J09_RS06625	COG0604	alcohol dehydrogenase
I3J09_RS06640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J09_RS06645	COG0473	3-isopropylmalate dehydrogenase activity
I3J09_RS06660	COG1082	Xylose isomerase domain protein TIM barrel
I3J09_RS06720	COG0640	Transcriptional regulator
I3J09_RS06725	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS06730	COG0506	proline dehydrogenase activity
I3J09_RS06735	COG2508	Transcriptional regulator
I3J09_RS06735	COG2508	Transcriptional regulator
I3J09_RS06740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J09_RS06745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J09_RS06750	COG0440	acetolactate synthase activity
I3J09_RS06770	COG0667	Aldo Keto reductase
I3J09_RS06775	COG2133	pyrroloquinoline quinone binding
I3J09_RS06785	COG1672	PFAM Archaeal ATPase
I3J09_RS06785	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J09_RS06800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J09_RS06805	COG2409	Drug exporters of the RND superfamily
I3J09_RS06815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J09_RS06825	COG0154	amidase activity
I3J09_RS06830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J09_RS06840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J09_RS06850	COG4221	oxidoreductase activity
I3J09_RS06855	COG1611	Belongs to the LOG family
I3J09_RS06865	COG0482	sulfurtransferase activity
I3J09_RS06890	COG2860	membrane
I3J09_RS06895	COG4608	Belongs to the ABC transporter superfamily
I3J09_RS06900	COG0444	Belongs to the ABC transporter superfamily
I3J09_RS06905	COG0601	transmembrane transport
I3J09_RS06910	COG0747	negative chemotaxis
I3J09_RS06915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J09_RS06935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J09_RS06940	COG0509	glycine decarboxylation via glycine cleavage system
I3J09_RS06945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J09_RS06950	COG1760	l-serine dehydratase
I3J09_RS06960	COG2856	Zn peptidase
I3J09_RS07090	COG1024	Enoyl-CoA hydratase
I3J09_RS07105	COG1132	(ABC) transporter
I3J09_RS07110	COG1132	(ABC) transporter
I3J09_RS07120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J09_RS07155	COG2197	response regulator
I3J09_RS07160	COG4585	Histidine kinase
I3J09_RS07170	COG0058	SHG alpha-glucan phosphorylase activity
I3J09_RS07175	COG0366	Alpha amylase catalytic
I3J09_RS07180	COG0366	Alpha amylase catalytic
I3J09_RS07190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J09_RS07205	COG1301	dicarboxylic acid transport
I3J09_RS07210	COG3290	protein histidine kinase activity
I3J09_RS07215	COG4565	transcriptional regulatory protein
I3J09_RS07220	COG0181	hydroxymethylbilane synthase activity
I3J09_RS07250	COG1175	transmembrane transport
I3J09_RS07260	COG0205	6-phosphofructokinase activity
I3J09_RS07265	COG0280	phosphate acetyltransferase
I3J09_RS07265	COG0857	belongs to the CobB CobQ family
I3J09_RS07270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J09_RS07305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS07305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS07350	COG0745	RESPONSE REGULATOR receiver
I3J09_RS07365	COG0183	Belongs to the thiolase family
I3J09_RS07385	COG1131	(ABC) transporter
I3J09_RS07420	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J09_RS07435	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J09_RS07450	COG4585	Histidine kinase
I3J09_RS07455	COG2197	response regulator
I3J09_RS07465	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J09_RS07485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J09_RS07515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J09_RS07525	COG0494	nUDIX hydrolase
I3J09_RS07540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J09_RS07545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J09_RS07550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J09_RS07555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J09_RS07560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J09_RS07565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J09_RS07570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J09_RS07590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J09_RS07595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J09_RS07605	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J09_RS07610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J09_RS07615	COG0254	rRNA binding
I3J09_RS07620	COG1316	TRANSCRIPTIONal
I3J09_RS07635	COG0083	homoserine kinase activity
I3J09_RS07640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J09_RS07645	COG0460	homoserine dehydrogenase
I3J09_RS07650	COG0019	diaminopimelate decarboxylase activity
I3J09_RS07655	COG0018	arginyl-trna synthetase
I3J09_RS07795	COG2367	Beta-lactamase
I3J09_RS07800	COG1686	Belongs to the peptidase S11 family
I3J09_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS07815	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J09_RS07820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J09_RS07840	COG2192	nodulation
I3J09_RS07850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J09_RS07860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J09_RS07870	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J09_RS07880	COG0768	penicillin binding
I3J09_RS07890	COG0367	asparagine synthase
I3J09_RS07895	COG0010	Belongs to the arginase family
I3J09_RS07900	COG2175	clavaminate synthase activity
I3J09_RS07940	COG0697	spore germination
I3J09_RS07945	COG0456	acetyltransferase
I3J09_RS07950	COG0747	negative chemotaxis
I3J09_RS07960	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J09_RS07965	COG0768	penicillin binding
I3J09_RS07970	COG0768	penicillin binding
I3J09_RS07975	COG2124	cytochrome p450
I3J09_RS07985	COG2205	protein histidine kinase activity
I3J09_RS07990	COG0745	RESPONSE REGULATOR receiver
I3J09_RS08010	COG2072	flavoprotein involved in K transport
I3J09_RS08015	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J09_RS08020	COG3285	dna ligase
I3J09_RS08020	COG1793	dna ligase
I3J09_RS08025	COG1793	dna ligase
I3J09_RS08080	COG0768	penicillin binding
I3J09_RS08110	COG2318	DinB family
I3J09_RS08145	COG2205	protein histidine kinase activity
I3J09_RS08165	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J09_RS08170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J09_RS08180	COG0745	RESPONSE REGULATOR receiver
I3J09_RS08185	COG2205	protein histidine kinase activity
I3J09_RS08190	COG0567	Dehydrogenase, E1 component
I3J09_RS08190	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J09_RS08200	COG2255	four-way junction helicase activity
I3J09_RS08235	COG0604	alcohol dehydrogenase
I3J09_RS08255	COG1126	abc transporter atp-binding protein
I3J09_RS08260	COG4106	trans-aconitate 2-methyltransferase activity
I3J09_RS08280	COG0494	nUDIX hydrolase
I3J09_RS08290	COG5640	endopeptidase activity
I3J09_RS08310	COG0142	geranyltranstransferase activity
I3J09_RS08345	COG1597	lipid kinase activity
I3J09_RS08360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J09_RS08365	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J09_RS08370	COG0395	ABC-type sugar transport system, permease component
I3J09_RS08375	COG1175	transmembrane transport
I3J09_RS08380	COG2182	Extracellular solute-binding protein
I3J09_RS08385	COG2188	Transcriptional regulator
I3J09_RS08410	COG0242	peptide deformylase activity
I3J09_RS08430	COG5662	AntiSigma factor
I3J09_RS08435	COG1595	DNA-templated transcription, initiation
I3J09_RS08445	COG2135	peptidase activity
I3J09_RS08455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J09_RS08465	COG2076	Multidrug Resistance protein
I3J09_RS08475	COG0483	inositol monophosphate 1-phosphatase activity
I3J09_RS08485	COG0753	catalase activity
I3J09_RS08510	COG1615	UPF0182 protein
I3J09_RS08520	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J09_RS08560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J09_RS08600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J09_RS08655	COG0601	transmembrane transport
I3J09_RS08660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J09_RS08665	COG0747	negative chemotaxis
I3J09_RS08675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J09_RS08675	COG0596	Alpha beta hydrolase
I3J09_RS08705	COG0513	Belongs to the DEAD box helicase family
I3J09_RS08730	COG1432	Conserved Protein
I3J09_RS08740	COG2095	MarC family integral membrane protein
I3J09_RS08760	COG0598	Magnesium transport protein CorA
I3J09_RS08795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J09_RS08800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J09_RS08810	COG1595	DNA-templated transcription, initiation
I3J09_RS08825	COG1024	Enoyl-CoA hydratase
I3J09_RS08830	COG0519	Catalyzes the synthesis of GMP from XMP
I3J09_RS08840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J09_RS08845	COG1611	Belongs to the LOG family
I3J09_RS08850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J09_RS08890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J09_RS08905	COG4608	Belongs to the ABC transporter superfamily
I3J09_RS08910	COG0444	Belongs to the ABC transporter superfamily
I3J09_RS08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J09_RS08920	COG0601	transmembrane transport
I3J09_RS08935	COG4608	Belongs to the ABC transporter superfamily
I3J09_RS08940	COG0444	Belongs to the ABC transporter superfamily
I3J09_RS08950	COG4166	transmembrane transport
I3J09_RS08955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J09_RS08960	COG1217	gtp-binding protein TYPA
I3J09_RS08980	COG1053	succinate dehydrogenase
I3J09_RS09030	COG0012	GTP binding
I3J09_RS09045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J09_RS09050	COG0531	amino acid
I3J09_RS09055	COG1570	exodeoxyribonuclease VII activity
I3J09_RS09060	COG1722	exodeoxyribonuclease VII activity
I3J09_RS09065	COG0778	Nitroreductase
I3J09_RS09090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J09_RS09090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J09_RS09100	COG0114	fumarate hydratase activity
I3J09_RS09120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J09_RS09140	COG1136	(ABC) transporter
I3J09_RS09155	COG0450	alkyl hydroperoxide reductase
I3J09_RS09160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J09_RS09175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J09_RS09180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J09_RS09185	COG0667	Aldo Keto reductase
I3J09_RS09210	COG2885	chlorophyll binding
I3J09_RS09230	COG2197	response regulator
I3J09_RS09235	COG4585	Histidine kinase
I3J09_RS09265	COG2894	cell division
I3J09_RS09290	COG2610	gluconate transmembrane transporter activity
I3J09_RS09295	COG0251	oxidation-reduction process
I3J09_RS09300	COG1414	Transcriptional regulator
I3J09_RS09315	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J09_RS09375	COG0492	ferredoxin-NADP+ reductase activity
I3J09_RS09410	COG0728	peptidoglycan biosynthetic process
I3J09_RS09420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J09_RS09425	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS09465	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J09_RS09475	COG1309	transcriptional regulator
I3J09_RS09480	COG1331	Highly conserved protein containing a thioredoxin domain
I3J09_RS09510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J09_RS09520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J09_RS09530	COG2188	Transcriptional regulator
I3J09_RS09550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J09_RS09590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J09_RS09610	COG1064	alcohol dehydrogenase
I3J09_RS09625	COG2986	histidine ammonia-lyase
I3J09_RS09635	COG1024	Enoyl-CoA hydratase
I3J09_RS09650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J09_RS09660	COG0424	maF-like protein
I3J09_RS09665	COG4770	biotin carboxylase activity
I3J09_RS09695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J09_RS09725	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS09745	COG1595	DNA-templated transcription, initiation
I3J09_RS09750	COG0745	RESPONSE REGULATOR receiver
I3J09_RS09755	COG2205	protein histidine kinase activity
I3J09_RS09780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J09_RS09795	COG0583	DNA-binding transcription factor activity
I3J09_RS09800	COG2814	Major facilitator Superfamily
I3J09_RS09835	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J09_RS09840	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J09_RS09845	COG3845	ABC transporter
I3J09_RS09850	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J09_RS09855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J09_RS09855	COG1473	amidohydrolase
I3J09_RS09865	COG2089	acid synthase
I3J09_RS09870	COG1083	cytidylyl-transferase
I3J09_RS09880	COG1216	Glycosyl transferase, family 2
I3J09_RS09895	COG0517	IMP dehydrogenase activity
I3J09_RS09895	COG0516	GMP reductase activity
I3J09_RS09910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS09910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS09925	COG1595	DNA-templated transcription, initiation
I3J09_RS09935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J09_RS09940	COG2009	succinate dehydrogenase
I3J09_RS09950	COG1053	succinate dehydrogenase
I3J09_RS09955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J09_RS09965	COG1408	metallophosphoesterase
I3J09_RS09975	COG1686	Belongs to the peptidase S11 family
I3J09_RS09980	COG1295	ribonuclease BN
I3J09_RS09985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J09_RS10010	COG0180	Tryptophanyl-tRNA synthetase
I3J09_RS10015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J09_RS10020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J09_RS10025	COG0754	glutathionylspermidine amidase activity
I3J09_RS10035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J09_RS10075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J09_RS10085	COG0039	L-malate dehydrogenase activity
I3J09_RS10100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J09_RS10115	COG0138	bifunctional purine biosynthesis protein purh
I3J09_RS10145	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J09_RS10150	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J09_RS10160	COG0714	Associated with various cellular activities
I3J09_RS10175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS10175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J09_RS10185	COG0739	heme binding
I3J09_RS10205	COG2197	response regulator
I3J09_RS10230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J09_RS10230	COG0519	Catalyzes the synthesis of GMP from XMP
I3J09_RS10250	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS10270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J09_RS10280	COG0516	GMP reductase activity
I3J09_RS10290	COG1595	DNA-templated transcription, initiation
I3J09_RS10295	COG2197	response regulator
I3J09_RS10305	COG0583	DNA-binding transcription factor activity
I3J09_RS10320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J09_RS10325	COG0459	protein refolding
I3J09_RS10330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J09_RS10335	COG0726	polysaccharide deacetylase
I3J09_RS10345	COG4941	Belongs to the sigma-70 factor family
I3J09_RS10370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J09_RS10395	COG0802	atpase or kinase
I3J09_RS10405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J09_RS10425	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J09_RS10430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J09_RS10435	COG1072	(Pantothenic acid kinase))
I3J09_RS10440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J09_RS10445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J09_RS10450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J09_RS10455	COG0488	(ABC) transporter
I3J09_RS10465	COG0101	tRNA pseudouridine synthase activity
I3J09_RS10470	COG0203	ribosomal protein L17
I3J09_RS10475	COG0202	RNA polymerase activity
I3J09_RS10480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J09_RS10485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J09_RS10490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J09_RS10495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J09_RS10505	COG0563	adenylate kinase activity
I3J09_RS10515	COG0200	Binds to the 23S rRNA
I3J09_RS10520	COG1841	ribosomal large subunit assembly
I3J09_RS10525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J09_RS10530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J09_RS10535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J09_RS10540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J09_RS10545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J09_RS10550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J09_RS10555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J09_RS10560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J09_RS10565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J09_RS10570	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J09_RS10575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J09_RS10580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J09_RS10585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J09_RS10590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J09_RS10595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J09_RS10600	COG0089	rRNA binding
I3J09_RS10605	COG0088	Forms part of the polypeptide exit tunnel
I3J09_RS10610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J09_RS10615	COG0051	transcription antitermination factor activity, RNA binding
I3J09_RS10625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J09_RS10630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J09_RS10635	COG0049	tRNA binding
I3J09_RS10640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J09_RS10645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J09_RS10650	COG0085	RNA polymerase activity
I3J09_RS10655	COG0222	ribosome binding
I3J09_RS10660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J09_RS10665	COG0081	regulation of translation
I3J09_RS10670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J09_RS10680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J09_RS10690	COG0436	Aminotransferase
I3J09_RS10695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J09_RS10700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J09_RS10710	COG2030	dehydratase
I3J09_RS10715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J09_RS10735	COG0702	epimerase
I3J09_RS10755	COG1666	GTP binding
I3J09_RS10760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J09_RS10770	COG3304	Inner membrane component domain
I3J09_RS10775	COG0501	Belongs to the peptidase M48B family
I3J09_RS10780	COG1007	ATP synthesis coupled electron transport
I3J09_RS10795	COG0713	ATP synthesis coupled electron transport
I3J09_RS10800	COG0839	Belongs to the complex I subunit 6 family
I3J09_RS10805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J09_RS10815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10830	COG4585	Histidine kinase
I3J09_RS10845	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J09_RS10845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J09_RS10850	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J09_RS10875	COG1733	regulation of RNA biosynthetic process
I3J09_RS10890	COG4935	Belongs to the peptidase S8 family
I3J09_RS10890	COG2234	aminopeptidase activity
I3J09_RS10915	COG0142	geranyltranstransferase activity
I3J09_RS10920	COG2936	dipeptidyl-peptidase activity
I3J09_RS10925	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J09_RS10930	COG1007	ATP synthesis coupled electron transport
I3J09_RS10940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J09_RS10945	COG0713	ATP synthesis coupled electron transport
I3J09_RS10950	COG0839	Belongs to the complex I subunit 6 family
I3J09_RS10955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J09_RS10965	COG1034	ATP synthesis coupled electron transport
I3J09_RS10970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J09_RS10980	COG0649	NAD binding
I3J09_RS10985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS10990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J09_RS11020	COG2226	methyltransferase
I3J09_RS11030	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J09_RS11035	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J09_RS11040	COG1278	Cold shock
I3J09_RS11045	COG1823	symporter activity
I3J09_RS11065	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J09_RS11075	COG0163	prenyltransferase activity
I3J09_RS11080	COG0109	protoheme IX farnesyltransferase activity
I3J09_RS11085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J09_RS11095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J09_RS11100	COG1333	cytochrome c biogenesis protein
I3J09_RS11105	COG0785	Cytochrome C biogenesis protein
I3J09_RS11110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J09_RS11115	COG0406	alpha-ribazole phosphatase activity
I3J09_RS11120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J09_RS11135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J09_RS11145	COG1742	UPF0060 membrane protein
I3J09_RS11160	COG0402	S-adenosylhomocysteine deaminase activity
I3J09_RS11165	COG1690	Belongs to the RtcB family
I3J09_RS11205	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J09_RS11210	COG0626	cystathionine gamma-synthase activity
I3J09_RS11225	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J09_RS11230	COG0018	arginyl-trna synthetase
I3J09_RS11250	COG0113	porphobilinogen synthase activity
I3J09_RS11355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J09_RS11360	COG0596	Alpha beta hydrolase
I3J09_RS11385	COG1136	(ABC) transporter
I3J09_RS11460	COG1725	Transcriptional regulator
I3J09_RS11480	COG1309	transcriptional regulator
I3J09_RS11500	COG0702	epimerase
I3J09_RS11510	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS11535	COG0259	pyridoxamine-phosphate oxidase activity
I3J09_RS11550	COG2072	flavoprotein involved in K transport
I3J09_RS11560	COG1024	Enoyl-CoA hydratase
I3J09_RS11570	COG0456	acetyltransferase
I3J09_RS11575	COG0477	Major facilitator Superfamily
I3J09_RS11575	COG2814	Major facilitator Superfamily
I3J09_RS11580	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J09_RS11595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J09_RS11600	COG2271	Major facilitator Superfamily
I3J09_RS11605	COG1917	Cupin 2, conserved barrel domain protein
I3J09_RS11605	COG4977	sequence-specific DNA binding
I3J09_RS11615	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS11635	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS11640	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS11650	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS11655	COG3397	chitin binding
I3J09_RS11725	COG2945	thiolester hydrolase activity
I3J09_RS11725	COG0596	Alpha beta hydrolase
I3J09_RS11735	COG4821	SIS domain
I3J09_RS11745	COG0259	pyridoxamine-phosphate oxidase activity
I3J09_RS11765	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS11780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J09_RS11845	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS11890	COG0726	polysaccharide deacetylase
I3J09_RS11920	COG0577	efflux transmembrane transporter activity
I3J09_RS11925	COG0577	efflux transmembrane transporter activity
I3J09_RS11925	COG1136	(ABC) transporter
I3J09_RS11960	COG0583	DNA-binding transcription factor activity
I3J09_RS11975	COG2205	protein histidine kinase activity
I3J09_RS11980	COG0745	RESPONSE REGULATOR receiver
I3J09_RS11995	COG0277	FAD linked oxidase domain protein
I3J09_RS11995	COG0247	lactate metabolic process
I3J09_RS12005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J09_RS12045	COG0463	Glycosyl transferase, family 2
I3J09_RS12055	COG3629	intracellular signal transduction
I3J09_RS12055	COG3903	Transcriptional regulator
I3J09_RS12070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J09_RS12110	COG1122	ATPase activity
I3J09_RS12130	COG0667	Aldo Keto reductase
I3J09_RS12165	COG2252	PERMEase
I3J09_RS12175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J09_RS12195	COG2814	Major facilitator Superfamily
I3J09_RS12205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J09_RS12210	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J09_RS12215	COG1278	Cold shock
I3J09_RS12250	COG1061	Type III restriction enzyme res subunit
I3J09_RS12260	COG3973	AAA domain
I3J09_RS12275	COG1595	DNA-templated transcription, initiation
I3J09_RS12350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J09_RS12355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J09_RS12365	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS12370	COG1605	Chorismate mutase
I3J09_RS12390	COG2197	response regulator
I3J09_RS12410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J09_RS12435	COG0191	fructose-bisphosphate aldolase activity
I3J09_RS12440	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J09_RS12455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J09_RS12460	COG2182	Extracellular solute-binding protein
I3J09_RS12485	COG0463	Glycosyl transferase, family 2
I3J09_RS12550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J09_RS12565	COG3842	ATPase activity
I3J09_RS12575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J09_RS12585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J09_RS12590	COG0215	cysteine-tRNA ligase activity
I3J09_RS12600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J09_RS12605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J09_RS12610	COG1329	Transcriptional regulator
I3J09_RS12625	COG5002	protein histidine kinase activity
I3J09_RS12640	COG0588	phosphoglycerate mutase activity
I3J09_RS12645	COG2211	Major facilitator Superfamily
I3J09_RS12670	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS12730	COG1490	D-aminoacyl-tRNA deacylase activity
I3J09_RS12745	COG3485	protocatechuate 3,4-dioxygenase
I3J09_RS12770	COG1309	transcriptional regulator
I3J09_RS12790	COG0745	RESPONSE REGULATOR receiver
I3J09_RS12795	COG1609	Transcriptional regulator
I3J09_RS12810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J09_RS12825	COG2188	Transcriptional regulator
I3J09_RS12835	COG1525	nuclease
I3J09_RS12835	COG4085	toxin activity
I3J09_RS12835	COG0737	Belongs to the 5'-nucleotidase family
I3J09_RS12855	COG0456	acetyltransferase
I3J09_RS12860	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J09_RS12870	COG0494	nUDIX hydrolase
I3J09_RS12870	COG0406	alpha-ribazole phosphatase activity
I3J09_RS12895	COG0306	phosphate transporter
I3J09_RS12905	COG1937	Protein conserved in bacteria
I3J09_RS12925	COG0671	phosphoesterase, PA-phosphatase related
I3J09_RS12930	COG1196	nuclear chromosome segregation
I3J09_RS12930	COG0739	heme binding
I3J09_RS12930	COG0741	lytic transglycosylase activity
I3J09_RS13025	COG0579	oxidoreductase
I3J09_RS13030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J09_RS13040	COG0739	heme binding
I3J09_RS13040	COG0741	lytic transglycosylase activity
I3J09_RS13040	COG1196	nuclear chromosome segregation
I3J09_RS13095	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J09_RS13105	COG0513	Belongs to the DEAD box helicase family
I3J09_RS13115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J09_RS13120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J09_RS13155	COG0785	Cytochrome C biogenesis protein
I3J09_RS13160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J09_RS13160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J09_RS13170	COG1643	Atp-dependent helicase
I3J09_RS13205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J09_RS13235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J09_RS13240	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J09_RS13245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J09_RS13280	COG2197	response regulator
I3J09_RS13290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J09_RS13305	COG0151	Belongs to the GarS family
I3J09_RS13330	COG0017	Asparaginyl-tRNA synthetase
I3J09_RS13335	COG1051	belongs to the nudix hydrolase family
I3J09_RS13345	COG0105	UTP biosynthetic process
I3J09_RS13385	COG2826	transposase and inactivated derivatives, IS30 family
I3J09_RS13415	COG3903	Transcriptional regulator
I3J09_RS13415	COG3629	intracellular signal transduction
I3J09_RS13480	COG0477	Major facilitator Superfamily
I3J09_RS13510	COG2234	aminopeptidase activity
I3J09_RS13515	COG0433	COG0433 Predicted ATPase
I3J09_RS13530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J09_RS13575	COG1191	sigma factor activity
I3J09_RS13580	COG1191	sigma factor activity
I3J09_RS13630	COG2304	oxidoreductase activity
I3J09_RS13635	COG2205	protein histidine kinase activity
I3J09_RS13640	COG0745	RESPONSE REGULATOR receiver
I3J09_RS13645	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J09_RS13665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J09_RS13690	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS13700	COG1362	aminopeptidase activity
I3J09_RS13720	COG2271	Major facilitator Superfamily
I3J09_RS13735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J09_RS13740	COG0022	dehydrogenase e1 component
I3J09_RS13765	COG0515	serine threonine protein kinase
I3J09_RS13770	COG0515	serine threonine protein kinase
I3J09_RS13785	COG1136	(ABC) transporter
I3J09_RS13785	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J09_RS13815	COG0303	'Molybdopterin
I3J09_RS13840	COG1522	sequence-specific DNA binding
I3J09_RS13845	COG1309	transcriptional regulator
I3J09_RS13850	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J09_RS13875	COG3396	Phenylacetate-CoA oxygenase
I3J09_RS13880	COG3460	Phenylacetate-CoA oxygenase
I3J09_RS13885	COG3396	Phenylacetate-CoA oxygenase
I3J09_RS13890	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J09_RS13895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J09_RS13900	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS13905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J09_RS13920	COG2197	response regulator
I3J09_RS13925	COG4585	Histidine kinase
I3J09_RS13950	COG0577	efflux transmembrane transporter activity
I3J09_RS13950	COG1136	(ABC) transporter
I3J09_RS13955	COG1136	(ABC) transporter
I3J09_RS13955	COG0577	efflux transmembrane transporter activity
I3J09_RS13965	COG1716	ATPase activity
I3J09_RS13970	COG1716	ATPase activity
I3J09_RS13985	COG0768	penicillin binding
I3J09_RS13990	COG0515	serine threonine protein kinase
I3J09_RS13995	COG3764	Sortase (surface protein transpeptidase)
I3J09_RS14000	COG3764	Sortase (surface protein transpeptidase)
I3J09_RS14015	COG3764	Sortase (surface protein transpeptidase)
I3J09_RS14030	COG0705	Rhomboid family
I3J09_RS14030	COG0457	Tetratricopeptide repeat
I3J09_RS14060	COG1446	asparaginase
I3J09_RS14065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J09_RS14070	COG1280	lysine exporter protein (LysE YggA)
I3J09_RS14075	COG1672	PFAM Archaeal ATPase
I3J09_RS14075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J09_RS14090	COG0667	Aldo Keto reductase
I3J09_RS14095	COG2175	clavaminate synthase activity
I3J09_RS14100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J09_RS14105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS14110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS14125	COG0515	serine threonine protein kinase
I3J09_RS14145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J09_RS14155	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J09_RS14160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J09_RS14165	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J09_RS14170	COG0592	DNA-directed DNA polymerase activity
I3J09_RS14180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J09_RS14185	COG0594	ribonuclease P activity
I3J09_RS14190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J09_RS14195	COG0706	membrane insertase activity
I3J09_RS14205	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J09_RS14210	COG1192	Involved in chromosome partitioning
I3J09_RS14225	COG3118	belongs to the thioredoxin family
I3J09_RS14230	COG0492	ferredoxin-NADP+ reductase activity
I3J09_RS14240	COG1595	DNA-templated transcription, initiation
I3J09_RS14245	COG2815	serine threonine protein kinase
I3J09_RS14245	COG0515	serine threonine protein kinase
I3J09_RS14260	COG0617	tRNA 3'-terminal CCA addition
I3J09_RS14280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J09_RS14305	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J09_RS14310	COG0629	single-stranded DNA binding
I3J09_RS14315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J09_RS14320	COG0359	binds to the 23S rRNA
I3J09_RS14330	COG0305	Participates in initiation and elongation during chromosome replication
I3J09_RS14365	COG0626	cystathionine gamma-synthase activity
I3J09_RS14370	COG1950	PFAM Membrane protein of
I3J09_RS14375	COG0662	Cupin 2, conserved barrel domain protein
I3J09_RS14395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J09_RS14410	COG1609	Transcriptional regulator
I3J09_RS14415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J09_RS14420	COG1271	oxidase subunit
I3J09_RS14425	COG1294	oxidase, subunit
I3J09_RS14430	COG4988	ABC transporter
I3J09_RS14440	COG0561	phosphatase activity
I3J09_RS14450	COG1131	(ABC) transporter
I3J09_RS14485	COG0561	phosphatase activity
I3J09_RS14490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J09_RS14495	COG0077	Prephenate dehydratase
I3J09_RS14500	COG2837	iron assimilation
I3J09_RS14515	COG1999	signal sequence binding
I3J09_RS14535	COG0006	proline dipeptidase activity
I3J09_RS14565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J09_RS14595	COG0587	DNA-directed DNA polymerase activity
I3J09_RS14600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J09_RS14625	COG1595	DNA-templated transcription, initiation
I3J09_RS14630	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS14635	COG0784	Response regulator, receiver
I3J09_RS14665	COG0745	RESPONSE REGULATOR receiver
I3J09_RS14670	COG0477	Major facilitator Superfamily
I3J09_RS14690	COG0431	NADPH-dependent FMN reductase
I3J09_RS14715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J09_RS14715	COG1672	PFAM Archaeal ATPase
I3J09_RS14720	COG0431	NADPH-dependent FMN reductase
I3J09_RS14750	COG0598	Magnesium transport protein CorA
I3J09_RS14755	COG3345	alpha-galactosidase
I3J09_RS14835	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J09_RS14845	COG2226	methyltransferase
I3J09_RS14850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J09_RS14890	COG2826	transposase and inactivated derivatives, IS30 family
I3J09_RS14995	COG1857	crispr-associated protein
I3J09_RS15015	COG0436	Aminotransferase
I3J09_RS15030	COG2197	response regulator
I3J09_RS15040	COG0577	efflux transmembrane transporter activity
I3J09_RS15100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J09_RS15125	COG3903	Transcriptional regulator
I3J09_RS15125	COG3629	intracellular signal transduction
I3J09_RS15175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J09_RS15185	COG0534	Mate efflux family protein
I3J09_RS15190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J09_RS15195	COG0019	diaminopimelate decarboxylase activity
I3J09_RS15210	COG4166	transmembrane transport
I3J09_RS15215	COG0601	transmembrane transport
I3J09_RS15220	COG4171	peptide transport system, permease
I3J09_RS15235	COG2197	response regulator
I3J09_RS15240	COG4585	Histidine kinase
I3J09_RS15245	COG2409	Drug exporters of the RND superfamily
I3J09_RS15270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J09_RS15280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J09_RS15285	COG0588	phosphoglycerate mutase activity
I3J09_RS15335	COG0717	Belongs to the dCTP deaminase family
I3J09_RS15350	COG0247	lactate metabolic process
I3J09_RS15350	COG2181	nitrate reductase activity
I3J09_RS15355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J09_RS15360	COG0443	Heat shock 70 kDa protein
I3J09_RS15365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J09_RS15370	COG0484	heat shock protein binding
I3J09_RS15375	COG0789	Transcriptional regulator
I3J09_RS15395	COG0542	response to heat
I3J09_RS15425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J09_RS15440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J09_RS15445	COG0191	fructose-bisphosphate aldolase activity
I3J09_RS15450	COG0477	Major facilitator Superfamily
I3J09_RS15485	COG4585	Histidine kinase
I3J09_RS15495	COG2124	cytochrome p450
I3J09_RS15525	COG0463	Glycosyl transferase, family 2
I3J09_RS15530	COG1802	Transcriptional regulator
I3J09_RS15545	COG2319	Wd-40 repeat
I3J09_RS15545	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J09_RS15550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS15585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J09_RS15600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J09_RS15605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J09_RS15620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J09_RS15625	COG1595	DNA-templated transcription, initiation
I3J09_RS15650	COG2124	cytochrome p450
I3J09_RS15665	COG2091	lysine biosynthetic process via aminoadipic acid
I3J09_RS15680	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J09_RS15710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J09_RS15795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J09_RS15815	COG1408	metallophosphoesterase
I3J09_RS15820	COG1610	YqeY-like protein
I3J09_RS15825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J09_RS15835	COG0003	Pfam Anion-transporting ATPase
I3J09_RS15865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J09_RS15895	COG2267	carboxylic ester hydrolase activity
I3J09_RS15905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J09_RS15910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J09_RS15915	COG0659	secondary active sulfate transmembrane transporter activity
I3J09_RS15975	COG1111	helicase
I3J09_RS15975	COG1205	dead DEAH box helicase
I3J09_RS15980	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J09_RS15985	COG2172	sigma factor antagonist activity
I3J09_RS15990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J09_RS16000	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J09_RS16010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J09_RS16010	COG1754	DNA topoisomerase type I activity
I3J09_RS16015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J09_RS16020	COG0470	DNA polymerase III
I3J09_RS16030	COG0477	Major facilitator Superfamily
I3J09_RS16070	COG1061	Type III restriction enzyme res subunit
I3J09_RS16115	COG0791	NLP P60 protein
I3J09_RS16195	COG0305	Participates in initiation and elongation during chromosome replication
I3J09_RS16355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J09_RS16465	COG1132	(ABC) transporter
I3J09_RS16470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J09_RS16470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J09_RS16475	COG0110	maltose O-acetyltransferase activity
I3J09_RS16515	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS16520	COG2318	DinB family
I3J09_RS16535	COG0076	glutamate decarboxylase activity
I3J09_RS16550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J09_RS16555	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J09_RS16565	COG0037	tRNA processing
I3J09_RS16580	COG0302	gtp cyclohydrolase
I3J09_RS16595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J09_RS16620	COG1174	glycine betaine transport
I3J09_RS16635	COG0649	NAD binding
I3J09_RS16650	COG2197	response regulator
I3J09_RS16665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J09_RS16670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J09_RS16680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J09_RS16700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J09_RS16715	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J09_RS16725	COG0739	heme binding
I3J09_RS16730	COG2205	protein histidine kinase activity
I3J09_RS16735	COG0745	RESPONSE REGULATOR receiver
I3J09_RS16745	COG1595	DNA-templated transcription, initiation
I3J09_RS16750	COG1194	a g-specific adenine glycosylase
I3J09_RS16755	COG0671	phosphoesterase, PA-phosphatase related
I3J09_RS16765	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J09_RS16785	COG0248	Ppx GppA phosphatase
I3J09_RS16795	COG0129	dihydroxy-acid dehydratase activity
I3J09_RS16815	COG2226	methyltransferase
I3J09_RS16820	COG1595	DNA-templated transcription, initiation
I3J09_RS16825	COG1252	NADH dehydrogenase
I3J09_RS16830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J09_RS16835	COG0180	Tryptophanyl-tRNA synthetase
I3J09_RS16860	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J09_RS16895	COG1595	DNA-templated transcription, initiation
I3J09_RS16910	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J09_RS16915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J09_RS16920	COG0181	hydroxymethylbilane synthase activity
I3J09_RS16925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J09_RS16925	COG1648	precorrin-2 dehydrogenase activity
I3J09_RS16950	COG1846	Transcriptional regulator
I3J09_RS16955	COG3384	dioxygenase
I3J09_RS16975	COG0477	Major facilitator Superfamily
I3J09_RS16985	COG3191	aminopeptidase activity
I3J09_RS17000	COG1970	mechanosensitive ion channel activity
I3J09_RS17010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J09_RS17035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J09_RS17040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J09_RS17050	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J09_RS17055	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J09_RS17055	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J09_RS17060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J09_RS17105	COG2072	flavoprotein involved in K transport
I3J09_RS17110	COG2267	carboxylic ester hydrolase activity
I3J09_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS17120	COG0793	Belongs to the peptidase S41A family
I3J09_RS17120	COG4946	Tricorn protease homolog
I3J09_RS17130	COG2409	Drug exporters of the RND superfamily
I3J09_RS17140	COG0310	cobalt ion transport
I3J09_RS17150	COG1122	ATPase activity
I3J09_RS17155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J09_RS17195	COG0124	histidyl-tRNA synthetase
I3J09_RS17220	COG3409	Peptidoglycan-binding domain 1 protein
I3J09_RS17225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J09_RS17245	COG0442	prolyl-tRNA aminoacylation
I3J09_RS17275	COG0084	hydrolase, TatD family'
I3J09_RS17285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J09_RS17290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J09_RS17315	COG0488	(ABC) transporter
I3J09_RS17345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J09_RS17350	COG2197	response regulator
I3J09_RS17360	COG4106	trans-aconitate 2-methyltransferase activity
I3J09_RS17365	COG1309	transcriptional regulator
I3J09_RS17375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J09_RS17385	COG0193	aminoacyl-tRNA hydrolase activity
I3J09_RS17390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J09_RS17395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J09_RS17400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J09_RS17410	COG4585	Histidine kinase
I3J09_RS17440	COG0477	Major facilitator Superfamily
I3J09_RS17455	COG1136	(ABC) transporter
I3J09_RS17460	COG0577	efflux transmembrane transporter activity
I3J09_RS17470	COG1595	DNA-templated transcription, initiation
I3J09_RS17495	COG0515	serine threonine protein kinase
I3J09_RS17495	COG2815	serine threonine protein kinase
I3J09_RS17525	COG1652	LysM domain
I3J09_RS17535	COG0148	phosphopyruvate hydratase activity
I3J09_RS17555	COG1252	NADH dehydrogenase
I3J09_RS17560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J09_RS17565	COG0577	efflux transmembrane transporter activity
I3J09_RS17565	COG1136	(ABC) transporter
I3J09_RS17570	COG1136	(ABC) transporter
I3J09_RS17570	COG0577	efflux transmembrane transporter activity
I3J09_RS17600	COG0183	Belongs to the thiolase family
I3J09_RS17605	COG2755	lipolytic protein G-D-S-L family
I3J09_RS17620	COG1737	Transcriptional regulator
I3J09_RS17680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J09_RS17710	COG1228	amidohydrolase
I3J09_RS17735	COG1191	sigma factor activity
I3J09_RS17760	COG3104	oligopeptide transport
I3J09_RS17765	COG0745	RESPONSE REGULATOR receiver
I3J09_RS17770	COG2205	protein histidine kinase activity
I3J09_RS17805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J09_RS17890	COG1309	transcriptional regulator
I3J09_RS17895	COG0596	Alpha beta hydrolase
I3J09_RS17900	COG1316	TRANSCRIPTIONal
I3J09_RS17905	COG1607	acyl-coa hydrolase
I3J09_RS17910	COG1316	TRANSCRIPTIONal
I3J09_RS17930	COG1316	TRANSCRIPTIONal
I3J09_RS17955	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J09_RS17955	COG0778	Nitroreductase
I3J09_RS17960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J09_RS17995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J09_RS18000	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J09_RS18010	COG1482	cell wall glycoprotein biosynthetic process
I3J09_RS18020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J09_RS18045	COG2826	transposase and inactivated derivatives, IS30 family
I3J09_RS18055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J09_RS18060	COG0745	RESPONSE REGULATOR receiver
I3J09_RS18065	COG5000	phosphorelay sensor kinase activity
I3J09_RS18065	COG5002	protein histidine kinase activity
I3J09_RS18070	COG0823	Involved in the tonB-independent uptake of proteins
I3J09_RS18080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J09_RS18085	COG2197	response regulator
I3J09_RS18090	COG3214	Protein conserved in bacteria
I3J09_RS18100	COG0653	protein targeting
I3J09_RS18125	COG2902	Dehydrogenase
I3J09_RS18135	COG0395	ABC-type sugar transport system, permease component
I3J09_RS18140	COG1175	transmembrane transport
I3J09_RS18155	COG0515	serine threonine protein kinase
I3J09_RS18160	COG0515	serine threonine protein kinase
I3J09_RS18165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J09_RS18175	COG2884	Cell division ATP-binding protein ftsE
I3J09_RS18185	COG0793	Belongs to the peptidase S41A family
I3J09_RS18190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J09_RS18205	COG0583	DNA-binding transcription factor activity
I3J09_RS18230	COG3973	AAA domain
I3J09_RS18240	COG0776	regulation of translation
I3J09_RS18245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J09_RS18250	COG1678	Uncharacterized ACR, COG1678
I3J09_RS18265	COG1175	transmembrane transport
I3J09_RS18270	COG0395	ABC-type sugar transport system, permease component
I3J09_RS18275	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J09_RS18315	COG3654	unkown
I3J09_RS18340	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J09_RS18345	COG0745	RESPONSE REGULATOR receiver
I3J09_RS18350	COG5002	protein histidine kinase activity
I3J09_RS18370	COG0277	FAD linked oxidase domain protein
I3J09_RS18410	COG1335	isochorismatase
I3J09_RS18420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J09_RS18430	COG1113	amino acid transport
I3J09_RS18440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J09_RS18445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS18450	COG1120	ATPase activity
I3J09_RS18465	COG1234	tRNA 3'-trailer cleavage
I3J09_RS18470	COG1263	PTS System
I3J09_RS18475	COG1263	PTS System
I3J09_RS18480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J09_RS18485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J09_RS18495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J09_RS18525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J09_RS18535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J09_RS18550	COG1131	(ABC) transporter
I3J09_RS18560	COG2733	membrane
I3J09_RS18590	COG0706	membrane insertase activity
I3J09_RS18600	COG0673	inositol 2-dehydrogenase activity
I3J09_RS18670	COG1126	abc transporter atp-binding protein
I3J09_RS18675	COG0765	amino acid transport
I3J09_RS18680	COG0765	amino acid transport
I3J09_RS18690	COG0154	amidase activity
I3J09_RS18700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS18735	COG0406	alpha-ribazole phosphatase activity
I3J09_RS18775	COG0745	RESPONSE REGULATOR receiver
I3J09_RS18790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J09_RS18795	COG4977	sequence-specific DNA binding
I3J09_RS18805	COG0589	response to stress
I3J09_RS18810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J09_RS18835	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J09_RS18840	COG0076	glutamate decarboxylase activity
I3J09_RS18850	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS18865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J09_RS18870	COG1309	transcriptional regulator
I3J09_RS18880	COG2124	cytochrome p450
I3J09_RS18885	COG1946	Acyl-CoA thioesterase
I3J09_RS18900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J09_RS18910	COG3960	tartronate-semialdehyde synthase activity
I3J09_RS18930	COG1674	ftsk spoiiie
I3J09_RS18995	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J09_RS19010	COG1609	Transcriptional regulator
I3J09_RS19015	COG0673	inositol 2-dehydrogenase activity
I3J09_RS19030	COG1595	DNA-templated transcription, initiation
I3J09_RS19040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J09_RS19065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J09_RS19075	COG3718	enzyme involved in inositol metabolism
I3J09_RS19080	COG3962	Belongs to the TPP enzyme family
I3J09_RS19100	COG1131	(ABC) transporter
I3J09_RS19160	COG0105	UTP biosynthetic process
I3J09_RS19165	COG2197	response regulator
I3J09_RS19175	COG2954	triphosphatase activity
I3J09_RS19185	COG0494	nUDIX hydrolase
I3J09_RS19215	COG0561	phosphatase activity
I3J09_RS19225	COG0475	glutathione-regulated potassium exporter activity
I3J09_RS19255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J09_RS19265	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J09_RS19270	COG1518	maintenance of DNA repeat elements
I3J09_RS19280	COG1203	CRISPR-associated helicase, Cas3
I3J09_RS19320	COG0629	single-stranded DNA binding
I3J09_RS19350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J09_RS19395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J09_RS19410	COG1486	melibiose metabolic process
I3J09_RS19415	COG0395	ABC-type sugar transport system, permease component
I3J09_RS19420	COG1175	transmembrane transport
I3J09_RS19440	COG0668	transmembrane transport
I3J09_RS19510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J09_RS19515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J09_RS19525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J09_RS19535	COG0588	phosphoglycerate mutase activity
I3J09_RS19540	COG1113	amino acid transport
I3J09_RS19550	COG1113	amino acid transport
I3J09_RS19565	COG4552	Acetyltransferase involved in intracellular survival and related
I3J09_RS19580	COG0475	glutathione-regulated potassium exporter activity
I3J09_RS19595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J09_RS19600	COG3594	Acyltransferase
I3J09_RS19620	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J09_RS19625	COG0740	serine-type endopeptidase activity
I3J09_RS19630	COG0740	serine-type endopeptidase activity
I3J09_RS19635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J09_RS19645	COG0525	valine-tRNA ligase activity
I3J09_RS19650	COG4585	Histidine kinase
I3J09_RS19655	COG0285	dihydrofolate synthase activity
I3J09_RS19665	COG0105	UTP biosynthetic process
I3J09_RS19670	COG1077	Cell shape determining protein MreB Mrl
I3J09_RS19690	COG0772	Belongs to the SEDS family
I3J09_RS19710	COG1530	ribonuclease E activity
I3J09_RS19720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J09_RS19725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J09_RS19730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J09_RS19735	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS19750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J09_RS19760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J09_RS19775	COG0501	Belongs to the peptidase M48B family
I3J09_RS19785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J09_RS19795	COG0799	negative regulation of ribosome biogenesis
I3J09_RS19800	COG0588	phosphoglycerate mutase activity
I3J09_RS19810	COG0495	leucyl-tRNA aminoacylation
I3J09_RS19820	COG1307	EDD domain protein, DegV family
I3J09_RS19855	COG0268	Binds directly to 16S ribosomal RNA
I3J09_RS19860	COG0481	GTPase activity
I3J09_RS19885	COG1420	regulation of RNA biosynthetic process
I3J09_RS19890	COG0484	heat shock protein binding
I3J09_RS19910	COG0793	Belongs to the peptidase S41A family
I3J09_RS19910	COG4946	Tricorn protease homolog
I3J09_RS19915	COG0537	adenosine 5'-monophosphoramidase activity
I3J09_RS19920	COG1234	tRNA 3'-trailer cleavage
I3J09_RS19925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J09_RS19930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J09_RS19940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J09_RS19980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J09_RS19995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J09_RS20010	COG1381	Involved in DNA repair and RecF pathway recombination
I3J09_RS20015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J09_RS20025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J09_RS20030	COG3842	ATPase activity
I3J09_RS20035	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J09_RS20035	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J09_RS20040	COG0423	glycine-tRNA ligase activity
I3J09_RS20080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J09_RS20080	COG0574	Belongs to the PEP-utilizing enzyme family
I3J09_RS20095	COG0531	amino acid
I3J09_RS20105	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS20110	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J09_RS20130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J09_RS20150	COG2949	membrane
I3J09_RS20155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J09_RS20165	COG0358	DNA primase activity
I3J09_RS20170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J09_RS20185	COG1070	Carbohydrate kinase
I3J09_RS20220	COG1129	ABC transporter
I3J09_RS20220	COG0842	Transport permease protein
I3J09_RS20280	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS20290	COG1136	(ABC) transporter
I3J09_RS20345	COG2130	NADP-dependent
I3J09_RS20380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J09_RS20385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J09_RS20390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J09_RS20415	COG0789	Transcriptional regulator
I3J09_RS20420	COG0667	Aldo Keto reductase
I3J09_RS20425	COG2197	response regulator
I3J09_RS20430	COG4585	Histidine kinase
I3J09_RS20450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J09_RS20455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J09_RS20500	COG1358	cellular component organization or biogenesis
I3J09_RS20510	COG0586	Pfam SNARE associated Golgi protein
I3J09_RS20535	COG0582	viral genome integration into host DNA
I3J09_RS20645	COG4122	O-methyltransferase activity
I3J09_RS20655	COG2124	cytochrome p450
I3J09_RS20660	COG0183	Belongs to the thiolase family
I3J09_RS20675	COG3845	ABC transporter
I3J09_RS20710	COG1309	transcriptional regulator
I3J09_RS20715	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS20720	COG2226	methyltransferase
I3J09_RS20730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS20750	COG0183	Belongs to the thiolase family
I3J09_RS20765	COG2030	dehydratase
I3J09_RS20770	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J09_RS20775	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS20790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J09_RS20810	COG0800	Aldolase
I3J09_RS20815	COG3022	response to hydroperoxide
I3J09_RS20830	COG0789	Transcriptional regulator
I3J09_RS20850	COG1349	DNA-binding transcription factor activity
I3J09_RS20855	COG1653	transport
I3J09_RS20865	COG0395	ABC-type sugar transport system, permease component
I3J09_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS20915	COG3540	Alkaline phosphatase
I3J09_RS20920	COG2814	Major facilitator Superfamily
I3J09_RS20935	COG1834	amidinotransferase
I3J09_RS20955	COG1120	ATPase activity
I3J09_RS20960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS20985	COG5398	heme oxygenase
I3J09_RS21020	COG1994	Peptidase M50
I3J09_RS21040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J09_RS21050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J09_RS21050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J09_RS21055	COG2132	Multicopper oxidase
I3J09_RS21090	COG0174	glutamine synthetase
I3J09_RS21105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J09_RS21120	COG1228	amidohydrolase
I3J09_RS21145	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J09_RS21150	COG0494	nUDIX hydrolase
I3J09_RS21165	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J09_RS21185	COG1609	Transcriptional regulator
I3J09_RS21190	COG0366	Alpha amylase catalytic
I3J09_RS21195	COG3833	ABC-type maltose transport systems, permease component
I3J09_RS21200	COG1175	transmembrane transport
I3J09_RS21230	COG2197	response regulator
I3J09_RS21270	COG0745	RESPONSE REGULATOR receiver
I3J09_RS21280	COG0673	inositol 2-dehydrogenase activity
I3J09_RS21305	COG0181	hydroxymethylbilane synthase activity
I3J09_RS21355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J09_RS21360	COG0321	lipoyl(octanoyl) transferase activity
I3J09_RS21375	COG1090	epimerase
I3J09_RS21405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J09_RS21415	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J09_RS21420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J09_RS21425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J09_RS21430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J09_RS21440	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J09_RS21470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J09_RS21475	COG1132	(ABC) transporter
I3J09_RS21500	COG4585	Histidine kinase
I3J09_RS21505	COG2197	response regulator
I3J09_RS21510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J09_RS21520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J09_RS21540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J09_RS21550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J09_RS21555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J09_RS21565	COG1376	ErfK ybiS ycfS ynhG family protein
I3J09_RS21575	COG1845	cytochrome c oxidase, subunit III
I3J09_RS21580	COG2010	Cytochrome c
I3J09_RS21585	COG0723	plastoquinol--plastocyanin reductase activity
I3J09_RS21590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J09_RS21595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J09_RS21600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J09_RS21605	COG1929	Belongs to the glycerate kinase type-1 family
I3J09_RS21615	COG0745	RESPONSE REGULATOR receiver
I3J09_RS21620	COG2205	protein histidine kinase activity
I3J09_RS21670	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS21695	COG0003	Pfam Anion-transporting ATPase
I3J09_RS21705	COG1940	carbohydrate kinase activity
I3J09_RS21735	COG2197	response regulator
I3J09_RS21740	COG0205	6-phosphofructokinase activity
I3J09_RS21750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J09_RS21755	COG0243	molybdopterin cofactor binding
I3J09_RS21760	COG2193	ferroxidase activity
I3J09_RS21765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J09_RS21770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J09_RS21775	COG2815	serine threonine protein kinase
I3J09_RS21775	COG0515	serine threonine protein kinase
I3J09_RS21780	COG2022	thiamine diphosphate biosynthetic process
I3J09_RS21790	COG2022	thiamine diphosphate biosynthetic process
I3J09_RS21790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J09_RS21810	COG0352	thiamine-phosphate diphosphorylase activity
I3J09_RS21825	COG1233	COG1233 Phytoene dehydrogenase and related
I3J09_RS21835	COG1309	transcriptional regulator
I3J09_RS21840	COG1511	domain protein
I3J09_RS21845	COG1121	(ABC) transporter
I3J09_RS21875	COG0714	Associated with various cellular activities
I3J09_RS21885	COG0275	rRNA processing
I3J09_RS21895	COG0768	penicillin binding
I3J09_RS21900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J09_RS21905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J09_RS21910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J09_RS21915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J09_RS21925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J09_RS21930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J09_RS21940	COG1496	oxidoreductase activity
I3J09_RS21950	COG1799	cell septum assembly
I3J09_RS21960	COG3599	regulation of cell shape
I3J09_RS21965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J09_RS21980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J09_RS22030	COG0587	DNA-directed DNA polymerase activity
I3J09_RS22040	COG1432	Conserved Protein
I3J09_RS22060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J09_RS22080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J09_RS22085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J09_RS22090	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J09_RS22100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J09_RS22105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J09_RS22110	COG0251	oxidation-reduction process
I3J09_RS22115	COG0107	imidazoleglycerol-phosphate synthase activity
I3J09_RS22130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J09_RS22135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J09_RS22155	COG0134	indole-3-glycerol-phosphate synthase activity
I3J09_RS22165	COG0133	tryptophan synthase activity
I3J09_RS22170	COG0159	tryptophan synthase activity
I3J09_RS22180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J09_RS22185	COG2301	Belongs to the HpcH HpaI aldolase family
I3J09_RS22190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J09_RS22195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J09_RS22230	COG0069	glutamate synthase activity
I3J09_RS22230	COG0070	glutamate synthase
I3J09_RS22230	COG0067	glutamate synthase
I3J09_RS22255	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS22265	COG1309	transcriptional regulator
I3J09_RS22270	COG0183	Belongs to the thiolase family
I3J09_RS22300	COG1024	Enoyl-CoA hydratase
I3J09_RS22310	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS22325	COG1470	cell adhesion involved in biofilm formation
I3J09_RS22325	COG0366	Alpha amylase catalytic
I3J09_RS22340	COG1605	Chorismate mutase
I3J09_RS22340	COG0287	Prephenate dehydrogenase
I3J09_RS22390	COG0411	ABC transporter
I3J09_RS22410	COG2050	protein possibly involved in aromatic compounds catabolism
I3J09_RS22440	COG1643	Atp-dependent helicase
I3J09_RS22445	COG2226	methyltransferase
I3J09_RS22445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J09_RS22445	COG0596	Alpha beta hydrolase
I3J09_RS22450	COG0539	negative regulation of cytoplasmic translation
I3J09_RS22460	COG0237	dephospho-CoA kinase activity
I3J09_RS22480	COG0330	HflC and HflK could
I3J09_RS22485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J09_RS22515	COG2313	pseudouridylate synthase activity
I3J09_RS22525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J09_RS22530	COG0584	glycerophosphoryl diester phosphodiesterase
I3J09_RS22540	COG0556	nucleotide-excision repair
I3J09_RS22560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J09_RS22570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J09_RS22575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J09_RS22575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J09_RS22600	COG0322	excinuclease ABC activity
I3J09_RS22605	COG1660	Displays ATPase and GTPase activities
I3J09_RS22610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J09_RS22615	COG1481	regulation of sporulation
I3J09_RS22625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J09_RS22630	COG0126	phosphoglycerate kinase activity
I3J09_RS22635	COG0149	triose-phosphate isomerase activity
I3J09_RS22640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J09_RS22650	COG0166	Belongs to the GPI family
I3J09_RS22655	COG3402	PFAM membrane-flanked domain
I3J09_RS22665	COG0363	glucosamine-6-phosphate deaminase activity
I3J09_RS22680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J09_RS22690	COG0109	protoheme IX farnesyltransferase activity
I3J09_RS22720	COG1131	(ABC) transporter
I3J09_RS22735	COG0719	Fe-S assembly protein
I3J09_RS22745	COG0396	ATPase activity
I3J09_RS22750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J09_RS22755	COG0822	iron-sulfur transferase activity
I3J09_RS22760	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J09_RS22765	COG2171	N-acyltransferase activity
I3J09_RS22775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J09_RS22825	COG2205	protein histidine kinase activity
I3J09_RS22830	COG0745	RESPONSE REGULATOR receiver
I3J09_RS22845	COG1802	Transcriptional regulator
I3J09_RS22860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J09_RS22865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J09_RS22875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J09_RS22885	COG0768	penicillin binding
I3J09_RS22890	COG2197	response regulator
I3J09_RS22895	COG4585	Histidine kinase
I3J09_RS22900	COG1414	Transcriptional regulator
I3J09_RS22925	COG1902	pentaerythritol trinitrate reductase activity
I3J09_RS22930	COG5285	phytanoyl-CoA dioxygenase
I3J09_RS22935	COG1917	Cupin 2, conserved barrel domain protein
I3J09_RS22950	COG0134	indole-3-glycerol-phosphate synthase activity
I3J09_RS22980	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J09_RS22995	COG1492	cobalamin metabolic process
I3J09_RS23000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J09_RS23015	COG0235	Class ii aldolase
I3J09_RS23030	COG0488	(ABC) transporter
I3J09_RS23040	COG1024	Enoyl-CoA hydratase
I3J09_RS23080	COG3387	PFAM Glycoside hydrolase 15-related
I3J09_RS23115	COG1404	Belongs to the peptidase S8 family
I3J09_RS23125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J09_RS23130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J09_RS23150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J09_RS23165	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS23170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J09_RS23175	COG2186	Transcriptional regulator
I3J09_RS23180	COG2807	transmembrane transport
I3J09_RS23195	COG3830	Belongs to the UPF0237 family
I3J09_RS23195	COG0560	Phosphoserine phosphatase
I3J09_RS23200	COG0842	Transport permease protein
I3J09_RS23200	COG1131	(ABC) transporter
I3J09_RS23200	COG1716	ATPase activity
I3J09_RS23210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J09_RS23220	COG4585	Histidine kinase
I3J09_RS23225	COG2197	response regulator
I3J09_RS23240	COG1119	ATPase activity
I3J09_RS23265	COG1881	PFAM PEBP family protein
I3J09_RS23275	COG2094	Belongs to the DNA glycosylase MPG family
I3J09_RS23310	COG0647	UMP catabolic process
I3J09_RS23315	COG1120	ATPase activity
I3J09_RS23335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J09_RS23340	COG0497	DNA recombination
I3J09_RS23345	COG0297	glycogen (starch) synthase activity
I3J09_RS23355	COG3387	PFAM Glycoside hydrolase 15-related
I3J09_RS23360	COG0504	CTP synthase activity
I3J09_RS23365	COG0494	nUDIX hydrolase
I3J09_RS23375	COG0686	Belongs to the AlaDH PNT family
I3J09_RS23390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J09_RS23395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J09_RS23400	COG1187	pseudouridine synthase activity
I3J09_RS23405	COG1056	cytidyltransferase-related domain
I3J09_RS23405	COG1051	belongs to the nudix hydrolase family
I3J09_RS23430	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J09_RS23440	COG1160	GTP binding
I3J09_RS23460	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS23470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J09_RS23480	COG0671	phosphoesterase, PA-phosphatase related
I3J09_RS23485	COG0477	Major facilitator Superfamily
I3J09_RS23490	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS23495	COG1799	cell septum assembly
I3J09_RS23545	COG0641	radical SAM
I3J09_RS23560	COG3903	Transcriptional regulator
I3J09_RS23560	COG3629	intracellular signal transduction
I3J09_RS23565	COG0596	Alpha beta hydrolase
I3J09_RS23590	COG4565	transcriptional regulatory protein
I3J09_RS23615	COG1725	Transcriptional regulator
I3J09_RS23625	COG2755	lipolytic protein G-D-S-L family
I3J09_RS23635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J09_RS23645	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J09_RS23650	COG2851	Citrate transporter
I3J09_RS23685	COG3876	Protein conserved in bacteria
I3J09_RS23700	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS23715	COG2149	membrane
I3J09_RS23735	COG3265	gluconokinase activity
I3J09_RS23740	COG2186	Transcriptional regulator
I3J09_RS23745	COG1113	amino acid transport
I3J09_RS23775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J09_RS23805	COG0667	Aldo Keto reductase
I3J09_RS23810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS23820	COG0598	Magnesium transport protein CorA
I3J09_RS23840	COG0215	cysteine-tRNA ligase activity
I3J09_RS23850	COG4948	Mandelate Racemase Muconate Lactonizing
I3J09_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS23865	COG1129	ABC transporter
I3J09_RS23875	COG2186	Transcriptional regulator
I3J09_RS23880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J09_RS23885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J09_RS23890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J09_RS23895	COG1414	Transcriptional regulator
I3J09_RS23900	COG1410	methionine synthase
I3J09_RS23900	COG0646	methionine synthase
I3J09_RS23905	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS23920	COG2197	response regulator
I3J09_RS23930	COG1994	Peptidase M50
I3J09_RS23930	COG0517	IMP dehydrogenase activity
I3J09_RS23950	COG1222	aaa ATPase
I3J09_RS23955	COG4122	O-methyltransferase activity
I3J09_RS23970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J09_RS23975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J09_RS23980	COG1609	Transcriptional regulator
I3J09_RS23990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J09_RS24025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J09_RS24030	COG0805	protein transport
I3J09_RS24065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J09_RS24070	COG4175	Glycine betaine
I3J09_RS24070	COG0517	IMP dehydrogenase activity
I3J09_RS24090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J09_RS24095	COG1113	amino acid transport
I3J09_RS24100	COG2186	Transcriptional regulator
I3J09_RS24105	COG0174	glutamine synthetase
I3J09_RS24130	COG1404	Belongs to the peptidase S8 family
I3J09_RS24150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J09_RS24155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J09_RS24160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J09_RS24165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J09_RS24170	COG5002	protein histidine kinase activity
I3J09_RS24175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J09_RS24180	COG0072	phenylalanine-tRNA ligase activity
I3J09_RS24180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J09_RS24200	COG1649	PFAM Uncharacterised BCR, COG1649
I3J09_RS24210	COG0697	spore germination
I3J09_RS24220	COG2838	Isocitrate dehydrogenase
I3J09_RS24245	COG4585	Histidine kinase
I3J09_RS24250	COG2197	response regulator
I3J09_RS24255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J09_RS24260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J09_RS24265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J09_RS24270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J09_RS24275	COG1438	arginine binding
I3J09_RS24280	COG0137	argininosuccinate synthase activity
I3J09_RS24285	COG0165	Argininosuccinate lyase
I3J09_RS24295	COG0477	Major facilitator Superfamily
I3J09_RS24300	COG0204	Acyl-transferase
I3J09_RS24300	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS24305	COG0584	glycerophosphoryl diester phosphodiesterase
I3J09_RS24325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J09_RS24330	COG2011	ABC-type metal ion transport system permease component
I3J09_RS24335	COG1464	Belongs to the NlpA lipoprotein family
I3J09_RS24350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J09_RS24355	COG1648	precorrin-2 dehydrogenase activity
I3J09_RS24355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J09_RS24400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J09_RS24410	COG0456	acetyltransferase
I3J09_RS24460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J09_RS24465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J09_RS24470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J09_RS24490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J09_RS24495	COG1560	Kdo2-lipid A biosynthetic process
I3J09_RS24500	COG0438	transferase activity, transferring glycosyl groups
I3J09_RS24510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J09_RS24515	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J09_RS24520	COG0217	transcriptional regulatory protein
I3J09_RS24525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J09_RS24530	COG0632	four-way junction helicase activity
I3J09_RS24535	COG2255	four-way junction helicase activity
I3J09_RS24545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J09_RS24550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J09_RS24555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J09_RS24560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J09_RS24570	COG1196	nuclear chromosome segregation
I3J09_RS24575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J09_RS24585	COG0124	histidyl-tRNA synthetase
I3J09_RS24605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J09_RS24620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J09_RS24625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J09_RS24630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J09_RS24635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J09_RS24640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J09_RS24645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J09_RS24650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J09_RS24655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J09_RS24665	COG0006	proline dipeptidase activity
I3J09_RS24670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J09_RS24675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J09_RS24685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J09_RS24690	COG0540	Belongs to the ATCase OTCase family
I3J09_RS24695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J09_RS24705	COG0505	Belongs to the CarA family
I3J09_RS24710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J09_RS24715	COG0167	dihydroorotate dehydrogenase activity
I3J09_RS24720	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J09_RS24745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J09_RS24760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J09_RS24770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J09_RS24775	COG2390	Transcriptional regulator
I3J09_RS24805	COG1191	sigma factor activity
I3J09_RS24815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J09_RS24830	COG2233	PERMEase
I3J09_RS24840	COG0738	Major facilitator superfamily
I3J09_RS24845	COG1940	carbohydrate kinase activity
I3J09_RS24845	COG1846	Transcriptional regulator
I3J09_RS24860	COG3201	nicotinamide mononucleotide transporter
I3J09_RS24865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J09_RS24865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J09_RS24870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J09_RS24875	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J09_RS24880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J09_RS24920	COG1309	transcriptional regulator
I3J09_RS24925	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS24945	COG1216	Glycosyl transferase, family 2
I3J09_RS24960	COG2270	Major facilitator Superfamily
I3J09_RS24970	COG2364	Membrane
I3J09_RS24975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J09_RS25005	COG1984	allophanate hydrolase subunit 2
I3J09_RS25010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J09_RS25015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J09_RS25020	COG2814	Major facilitator Superfamily
I3J09_RS25050	COG5002	protein histidine kinase activity
I3J09_RS25055	COG2018	Roadblock/LC7 domain
I3J09_RS25070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J09_RS25075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J09_RS25080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J09_RS25100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J09_RS25110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J09_RS25140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J09_RS25160	COG1716	ATPase activity
I3J09_RS25180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J09_RS25190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J09_RS25190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J09_RS25255	COG0697	spore germination
I3J09_RS25310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J09_RS25325	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J09_RS25335	COG2813	Specifically methylates the guanine in position
I3J09_RS25350	COG1968	undecaprenyl-diphosphatase activity
I3J09_RS25365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J09_RS25390	COG2124	cytochrome p450
I3J09_RS25420	COG0110	maltose O-acetyltransferase activity
I3J09_RS25425	COG1832	CoA-binding protein
I3J09_RS25430	COG1739	Uncharacterized protein family UPF0029
I3J09_RS25440	COG0666	response to abiotic stimulus
I3J09_RS25445	COG0420	3'-5' exonuclease activity
I3J09_RS25450	COG0419	ATPase involved in DNA repair
I3J09_RS25450	COG0419	ATPase involved in DNA repair
I3J09_RS25455	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS25485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J09_RS25500	COG2188	Transcriptional regulator
I3J09_RS25505	COG1940	carbohydrate kinase activity
I3J09_RS25515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J09_RS25550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J09_RS25555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS25560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J09_RS25580	COG0740	serine-type endopeptidase activity
I3J09_RS25590	COG0831	urea catabolic process
I3J09_RS25595	COG0832	Belongs to the urease beta subunit family
I3J09_RS25600	COG0804	urea catabolic process
I3J09_RS25610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J09_RS25615	COG0829	nickel cation binding
I3J09_RS25625	COG0204	Acyl-transferase
I3J09_RS25640	COG0142	geranyltranstransferase activity
I3J09_RS25645	COG0142	geranyltranstransferase activity
I3J09_RS25665	COG0205	6-phosphofructokinase activity
I3J09_RS25670	COG3442	glutamine amidotransferase
I3J09_RS25680	COG0242	peptide deformylase activity
I3J09_RS25690	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS25715	COG0386	Belongs to the glutathione peroxidase family
I3J09_RS25720	COG1946	Acyl-CoA thioesterase
I3J09_RS25740	COG1132	(ABC) transporter
I3J09_RS25740	COG2375	cellular response to nickel ion
I3J09_RS25745	COG1132	(ABC) transporter
I3J09_RS25755	COG2409	Drug exporters of the RND superfamily
I3J09_RS25770	COG2124	cytochrome p450
I3J09_RS25780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J09_RS25790	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS25805	COG0477	Major facilitator Superfamily
I3J09_RS25835	COG4585	Histidine kinase
I3J09_RS25840	COG2197	response regulator
I3J09_RS25860	COG2409	Drug exporters of the RND superfamily
I3J09_RS25870	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J09_RS25870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J09_RS25875	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J09_RS25930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J09_RS25935	COG0604	alcohol dehydrogenase
I3J09_RS25935	COG3321	synthase
I3J09_RS25950	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS25970	COG1132	(ABC) transporter
I3J09_RS25975	COG2072	flavoprotein involved in K transport
I3J09_RS26035	COG0443	Heat shock 70 kDa protein
I3J09_RS26050	COG1309	transcriptional regulator
I3J09_RS26060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS26065	COG1902	pentaerythritol trinitrate reductase activity
I3J09_RS26120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J09_RS26165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS26170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS26175	COG1120	ATPase activity
I3J09_RS26185	COG1132	(ABC) transporter
I3J09_RS26210	COG4607	ABC-type enterochelin transport system periplasmic component
I3J09_RS26215	COG0464	growth
I3J09_RS26220	COG1404	Belongs to the peptidase S8 family
I3J09_RS26225	COG1674	ftsk spoiiie
I3J09_RS26290	COG1278	Cold shock
I3J09_RS26305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J09_RS26315	COG0577	efflux transmembrane transporter activity
I3J09_RS26315	COG1136	(ABC) transporter
I3J09_RS26320	COG1136	(ABC) transporter
I3J09_RS26320	COG0577	efflux transmembrane transporter activity
I3J09_RS26335	COG0745	RESPONSE REGULATOR receiver
I3J09_RS26340	COG2205	protein histidine kinase activity
I3J09_RS26375	COG0463	Glycosyl transferase, family 2
I3J09_RS26380	COG0326	Molecular chaperone. Has ATPase activity
I3J09_RS26420	COG0309	Hydrogenase expression formation protein (HypE)
I3J09_RS26430	COG0298	carbon dioxide binding
I3J09_RS26440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J09_RS26445	COG0375	protein maturation
I3J09_RS26525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J09_RS26560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J09_RS26575	COG2706	6-phosphogluconolactonase activity
I3J09_RS26590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J09_RS26615	COG1309	transcriptional regulator
I3J09_RS26620	COG0671	phosphoesterase, PA-phosphatase related
I3J09_RS26645	COG0584	glycerophosphoryl diester phosphodiesterase
I3J09_RS26665	COG0204	Acyl-transferase
I3J09_RS26675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J09_RS26695	COG3345	alpha-galactosidase
I3J09_RS26705	COG1175	transmembrane transport
I3J09_RS26710	COG0395	ABC-type sugar transport system, permease component
I3J09_RS26730	COG0644	oxidoreductase
I3J09_RS26745	COG1940	carbohydrate kinase activity
I3J09_RS26765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J09_RS26775	COG1349	DNA-binding transcription factor activity
I3J09_RS26795	COG1215	transferase activity, transferring glycosyl groups
I3J09_RS26800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J09_RS26885	COG1486	melibiose metabolic process
I3J09_RS26930	COG1012	belongs to the aldehyde dehydrogenase family
I3J09_RS26935	COG0363	glucosamine-6-phosphate deaminase activity
I3J09_RS26960	COG1461	Dihydroxyacetone kinase
I3J09_RS26965	COG2376	Dihydroxyacetone kinase
I3J09_RS27000	COG1131	(ABC) transporter
I3J09_RS27055	COG1846	Transcriptional regulator
I3J09_RS27090	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J09_RS27095	COG1959	2 iron, 2 sulfur cluster binding
I3J09_RS27100	COG1017	nitric oxide dioxygenase activity
I3J09_RS27100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J09_RS27120	COG3511	phospholipase C
I3J09_RS27130	COG1796	DNA polymerase
I3J09_RS27130	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J09_RS27140	COG2814	Major facilitator Superfamily
I3J09_RS27180	COG1960	acyl-CoA dehydrogenase activity
I3J09_RS27190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J09_RS27205	COG1335	isochorismatase
I3J09_RS27210	COG0010	Belongs to the arginase family
I3J09_RS27215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J09_RS27260	COG0701	Predicted permease
I3J09_RS27270	COG2815	serine threonine protein kinase
I3J09_RS27270	COG0515	serine threonine protein kinase
I3J09_RS27280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J09_RS27285	COG2070	2-Nitropropane dioxygenase
I3J09_RS27295	COG0387	Pfam Sodium calcium exchanger
I3J09_RS27300	COG2267	carboxylic ester hydrolase activity
I3J09_RS27305	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS27370	COG1132	(ABC) transporter
I3J09_RS27370	COG2375	cellular response to nickel ion
I3J09_RS27385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J09_RS27385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J09_RS27395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J09_RS27400	COG0765	amino acid transport
I3J09_RS27405	COG1126	abc transporter atp-binding protein
I3J09_RS27425	COG1957	nucleoside hydrolase
I3J09_RS27435	COG2318	DinB family
I3J09_RS27455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS27460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J09_RS27505	COG0501	Belongs to the peptidase M48B family
I3J09_RS27545	COG4412	M6 family metalloprotease domain protein
I3J09_RS27545	COG1404	Belongs to the peptidase S8 family
I3J09_RS27545	COG1404	Belongs to the peptidase S8 family
I3J09_RS27545	COG4412	M6 family metalloprotease domain protein
I3J09_RS27600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J09_RS27615	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS27650	COG0288	reversible hydration of carbon dioxide
I3J09_RS27660	COG0702	epimerase
I3J09_RS27670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J09_RS27685	COG2226	methyltransferase
I3J09_RS27695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J09_RS27700	COG1937	Protein conserved in bacteria
I3J09_RS27730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J09_RS27795	COG0142	geranyltranstransferase activity
I3J09_RS27805	COG1132	(ABC) transporter
I3J09_RS27815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J09_RS28080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J09_RS28125	COG2161	toxin-antitoxin pair type II binding
I3J09_RS28170	COG3547	Transposase (IS116 IS110 IS902 family)
I3J09_RS28180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J09_RS28185	COG0318	PFAM AMP-dependent synthetase and ligase
I3J09_RS28255	COG2197	response regulator
I3J09_RS28285	COG2814	Major facilitator Superfamily
I3J09_RS28290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J09_RS28305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J09_RS28345	COG0604	alcohol dehydrogenase
I3J09_RS28345	COG3321	synthase
I3J09_RS28365	COG2814	Major facilitator Superfamily
I3J09_RS28385	COG0076	glutamate decarboxylase activity
I3J09_RS28420	COG0531	amino acid
I3J09_RS28430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J09_RS28445	COG2304	oxidoreductase activity
I3J09_RS28485	COG2197	response regulator
I3J09_RS28495	COG1222	aaa ATPase
I3J09_RS28505	COG3903	Transcriptional regulator
I3J09_RS28505	COG3629	intracellular signal transduction
I3J09_RS28580	COG2124	cytochrome p450
I3J09_RS28610	COG0789	Transcriptional regulator
I3J09_RS28615	COG0436	Aminotransferase
I3J09_RS28625	COG1695	Transcriptional regulator
I3J09_RS28630	COG2124	cytochrome p450
I3J09_RS28635	COG2124	cytochrome p450
I3J09_RS28640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J09_RS28645	COG0346	lactoylglutathione lyase activity
I3J09_RS28650	COG0640	Transcriptional regulator
I3J09_RS28660	COG2226	methyltransferase
I3J09_RS28670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J09_RS28720	COG0577	efflux transmembrane transporter activity
I3J09_RS28720	COG1136	(ABC) transporter
I3J09_RS28725	COG1136	(ABC) transporter
I3J09_RS28725	COG0577	efflux transmembrane transporter activity
I3J09_RS28740	COG0745	RESPONSE REGULATOR receiver
I3J09_RS28745	COG2205	protein histidine kinase activity
I3J09_RS28775	COG4948	Mandelate Racemase Muconate Lactonizing
I3J09_RS28810	COG2124	cytochrome p450
I3J09_RS28820	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS28930	COG2124	cytochrome p450
I3J09_RS28955	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J09_RS28990	COG2319	Wd-40 repeat
I3J09_RS28990	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J09_RS28995	COG1335	isochorismatase
I3J09_RS29035	COG3409	Peptidoglycan-binding domain 1 protein
I3J09_RS29040	COG3973	AAA domain
I3J09_RS29070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J09_RS29075	COG5183	chlorophyll binding
I3J09_RS29075	COG2133	pyrroloquinoline quinone binding
I3J09_RS29100	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS29110	COG2201	protein-glutamate methylesterase activity
I3J09_RS29125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS29130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J09_RS29135	COG0010	Belongs to the arginase family
I3J09_RS29140	COG0367	asparagine synthase
I3J09_RS29160	COG0436	Aminotransferase
I3J09_RS29165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J09_RS29175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J09_RS29190	COG0583	DNA-binding transcription factor activity
I3J09_RS29235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J09_RS29235	COG2111	Na H antiporter
I3J09_RS29240	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J09_RS29245	COG0651	ATP synthesis coupled electron transport
I3J09_RS29260	COG1320	monovalent cation:proton antiporter activity
I3J09_RS29415	COG3959	Transketolase, thiamine diphosphate binding domain
I3J09_RS29420	COG3958	Transketolase
I3J09_RS29455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J09_RS29460	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS29465	COG0277	FAD linked oxidase domain protein
I3J09_RS29470	COG1070	Carbohydrate kinase
I3J09_RS29515	COG2124	cytochrome p450
I3J09_RS29525	COG1011	Hydrolase
I3J09_RS29565	COG0789	Transcriptional regulator
I3J09_RS29575	COG3397	chitin binding
I3J09_RS29605	COG1132	(ABC) transporter
I3J09_RS29665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J09_RS29670	COG2124	cytochrome p450
I3J09_RS29685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J09_RS29705	COG3409	Peptidoglycan-binding domain 1 protein
I3J09_RS29705	COG3757	hydrolase, family 25
I3J09_RS29740	COG0488	(ABC) transporter
I3J09_RS29770	COG0698	ribose 5-phosphate isomerase
I3J09_RS29805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J09_RS29815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J09_RS29830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J09_RS29840	COG2267	carboxylic ester hydrolase activity
I3J09_RS29920	COG0477	Major facilitator Superfamily
I3J09_RS29965	COG1028	Short-chain dehydrogenase reductase Sdr
I3J09_RS30000	COG2226	methyltransferase
I3J09_RS30015	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J09_RS30030	COG3409	Peptidoglycan-binding domain 1 protein
I3J09_RS30070	COG0494	nUDIX hydrolase
I3J09_RS30085	COG3629	intracellular signal transduction
I3J09_RS30085	COG3903	Transcriptional regulator
I3J09_RS30110	COG1725	Transcriptional regulator
I3J09_RS30115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3J09_RS30125	COG1309	transcriptional regulator
I3J09_RS30150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J09_RS30200	COG2318	DinB family
I3J09_RS30295	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J09_RS30295	COG2319	Wd-40 repeat
I3J09_RS30325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J09_RS30330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J09_RS30345	COG0431	NADPH-dependent FMN reductase
I3J09_RS30355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS30360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS30365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J09_RS30400	COG0640	Transcriptional regulator
I3J09_RS30420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J09_RS30430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J09_RS30435	COG0301	tRNA thio-modification
I3J09_RS30465	COG1024	Enoyl-CoA hydratase
I3J09_RS30510	COG0110	maltose O-acetyltransferase activity
I3J09_RS30550	COG0477	Major facilitator Superfamily
I3J09_RS30590	COG0546	phosphoglycolate phosphatase activity
I3J09_RS30605	COG0363	glucosamine-6-phosphate deaminase activity
I3J09_RS30610	COG1940	carbohydrate kinase activity
I3J09_RS30635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J09_RS30645	COG4552	Acetyltransferase involved in intracellular survival and related
I3J09_RS30655	COG2816	NAD+ diphosphatase activity
I3J09_RS30665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J09_RS30670	COG1228	amidohydrolase
I3J09_RS30725	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J09_RS30730	COG1732	Glycine betaine
I3J09_RS30735	COG1174	glycine betaine transport
I3J09_RS30740	COG0517	IMP dehydrogenase activity
I3J09_RS30740	COG1125	glycine betaine transport
I3J09_RS30755	COG0076	glutamate decarboxylase activity
I3J09_RS30775	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J09_RS30780	COG1121	(ABC) transporter
I3J09_RS30825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs