locus-tag	class	description
I3J16_RS00015	COG1966	Carbon starvation protein
I3J16_RS00040	COG0019	diaminopimelate decarboxylase activity
I3J16_RS00065	COG0475	glutathione-regulated potassium exporter activity
I3J16_RS00065	COG0569	domain protein
I3J16_RS00090	COG2814	Major facilitator Superfamily
I3J16_RS00115	COG1063	alcohol dehydrogenase
I3J16_RS00120	COG0156	8-amino-7-oxononanoate synthase activity
I3J16_RS00130	COG2018	Roadblock/LC7 domain
I3J16_RS00145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J16_RS00165	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS00170	COG0531	amino acid
I3J16_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS00185	COG0142	geranyltranstransferase activity
I3J16_RS00200	COG2124	cytochrome p450
I3J16_RS00230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J16_RS00255	COG4310	Domain of unknown function (DUF2172)
I3J16_RS00270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J16_RS00280	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS00280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J16_RS00315	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS00320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J16_RS00355	COG0473	3-isopropylmalate dehydrogenase activity
I3J16_RS00400	COG1846	Transcriptional regulator
I3J16_RS00415	COG0542	response to heat
I3J16_RS00420	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J16_RS00420	COG2172	sigma factor antagonist activity
I3J16_RS00420	COG2208	phosphoserine phosphatase activity
I3J16_RS00435	COG1653	transport
I3J16_RS00440	COG1233	COG1233 Phytoene dehydrogenase and related
I3J16_RS00465	COG1233	COG1233 Phytoene dehydrogenase and related
I3J16_RS00470	COG2130	NADP-dependent
I3J16_RS00475	COG2376	Dihydroxyacetone kinase
I3J16_RS00480	COG2376	Dihydroxyacetone kinase
I3J16_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS00535	COG2124	cytochrome p450
I3J16_RS00575	COG1124	(ABC) transporter
I3J16_RS00580	COG0444	Belongs to the ABC transporter superfamily
I3J16_RS00585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS00590	COG0601	transmembrane transport
I3J16_RS00600	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS00605	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS00635	COG0517	IMP dehydrogenase activity
I3J16_RS00635	COG1125	glycine betaine transport
I3J16_RS00640	COG3458	cephalosporin-C deacetylase activity
I3J16_RS00655	COG1174	glycine betaine transport
I3J16_RS00660	COG1174	glycine betaine transport
I3J16_RS00670	COG1309	transcriptional regulator
I3J16_RS00690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J16_RS00705	COG2124	cytochrome p450
I3J16_RS00730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J16_RS00750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J16_RS00750	COG1024	Enoyl-CoA hydratase
I3J16_RS00775	COG2124	cytochrome p450
I3J16_RS00810	COG0463	Glycosyl transferase, family 2
I3J16_RS00825	COG0402	S-adenosylhomocysteine deaminase activity
I3J16_RS00845	COG1413	lyase activity
I3J16_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS00895	COG2326	polyphosphate kinase activity
I3J16_RS00900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J16_RS00950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J16_RS00955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J16_RS00960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J16_RS01010	COG0183	Belongs to the thiolase family
I3J16_RS01030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J16_RS01035	COG1376	ErfK ybiS ycfS ynhG family protein
I3J16_RS01055	COG0535	radical SAM domain protein
I3J16_RS01065	COG3424	synthase
I3J16_RS01110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J16_RS01115	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J16_RS01200	COG1131	(ABC) transporter
I3J16_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS01250	COG1309	transcriptional regulator
I3J16_RS01285	COG3903	Transcriptional regulator
I3J16_RS01285	COG3629	intracellular signal transduction
I3J16_RS01290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J16_RS01295	COG1597	lipid kinase activity
I3J16_RS01315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J16_RS01315	COG0574	Belongs to the PEP-utilizing enzyme family
I3J16_RS01355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J16_RS01360	COG0477	Major facilitator Superfamily
I3J16_RS01380	COG1174	glycine betaine transport
I3J16_RS01385	COG1174	glycine betaine transport
I3J16_RS01420	COG2957	Belongs to the agmatine deiminase family
I3J16_RS01440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J16_RS01480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J16_RS01490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J16_RS01500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS01515	COG2207	Transcriptional regulator
I3J16_RS01520	COG1120	ATPase activity
I3J16_RS01525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J16_RS01540	COG4552	Acetyltransferase involved in intracellular survival and related
I3J16_RS01560	COG2197	response regulator
I3J16_RS01565	COG0154	amidase activity
I3J16_RS01570	COG0477	Major facilitator Superfamily
I3J16_RS01575	COG0579	oxidoreductase
I3J16_RS01595	COG2755	lipolytic protein G-D-S-L family
I3J16_RS01595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J16_RS01610	COG0745	RESPONSE REGULATOR receiver
I3J16_RS01615	COG2205	protein histidine kinase activity
I3J16_RS01630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J16_RS01660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J16_RS01665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J16_RS01675	COG1609	Transcriptional regulator
I3J16_RS01680	COG0596	Alpha beta hydrolase
I3J16_RS01695	COG3572	ergothioneine biosynthetic process
I3J16_RS01700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J16_RS01705	COG0121	glutamine amidotransferase
I3J16_RS01710	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J16_RS01715	COG2182	Extracellular solute-binding protein
I3J16_RS01720	COG3360	Dodecin
I3J16_RS01730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J16_RS01750	COG3300	MHYT domain
I3J16_RS01750	COG5001	Diguanylate cyclase
I3J16_RS01795	COG3275	phosphorelay sensor kinase activity
I3J16_RS01800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J16_RS01815	COG3279	Response regulator of the LytR AlgR family
I3J16_RS01830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J16_RS01885	COG0297	glycogen (starch) synthase activity
I3J16_RS01905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J16_RS01915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J16_RS01925	COG3845	ABC transporter
I3J16_RS01960	COG2205	protein histidine kinase activity
I3J16_RS01965	COG0745	RESPONSE REGULATOR receiver
I3J16_RS01995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J16_RS02015	COG0248	Ppx GppA phosphatase
I3J16_RS02060	COG1175	transmembrane transport
I3J16_RS02065	COG0395	ABC-type sugar transport system, permease component
I3J16_RS02080	COG1051	belongs to the nudix hydrolase family
I3J16_RS02085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J16_RS02095	COG2318	DinB family
I3J16_RS02110	COG3251	PFAM MbtH domain protein
I3J16_RS02115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J16_RS02125	COG0667	Aldo Keto reductase
I3J16_RS02180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J16_RS02185	COG0842	Transport permease protein
I3J16_RS02185	COG1129	ABC transporter
I3J16_RS02210	COG2072	flavoprotein involved in K transport
I3J16_RS02235	COG1556	Lactate utilization protein
I3J16_RS02240	COG1139	Iron-sulfur cluster binding protein
I3J16_RS02245	COG0247	lactate metabolic process
I3J16_RS02290	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS02325	COG0500	methyltransferase
I3J16_RS02330	COG4981	capsule polysaccharide biosynthetic process
I3J16_RS02380	COG0477	Major facilitator Superfamily
I3J16_RS02400	COG2226	methyltransferase
I3J16_RS02410	COG0187	DNA topoisomerase II activity
I3J16_RS02450	COG0673	inositol 2-dehydrogenase activity
I3J16_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS02500	COG2850	peptidyl-arginine hydroxylation
I3J16_RS02560	COG3511	phospholipase C
I3J16_RS02650	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS02695	COG1116	anion transmembrane transporter activity
I3J16_RS02705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J16_RS02710	COG4948	Mandelate Racemase Muconate Lactonizing
I3J16_RS02715	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS02750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J16_RS02755	COG1309	transcriptional regulator
I3J16_RS02765	COG0739	heme binding
I3J16_RS02765	COG0741	lytic transglycosylase activity
I3J16_RS02765	COG1196	nuclear chromosome segregation
I3J16_RS02775	COG2365	Tyrosine phosphatase family
I3J16_RS02805	COG1657	PFAM Prenyltransferase squalene oxidase
I3J16_RS02815	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J16_RS02825	COG1562	ergosterol biosynthetic process
I3J16_RS02830	COG1134	teichoic acid transport
I3J16_RS02845	COG0371	Dehydrogenase
I3J16_RS02870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J16_RS02885	COG1024	Enoyl-CoA hydratase
I3J16_RS02900	COG2183	response to ionizing radiation
I3J16_RS02915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J16_RS02925	COG2936	dipeptidyl-peptidase activity
I3J16_RS02945	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J16_RS02945	COG1024	Enoyl-CoA hydratase
I3J16_RS02950	COG0183	Belongs to the thiolase family
I3J16_RS02955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J16_RS02960	COG3268	Saccharopine dehydrogenase
I3J16_RS02965	COG1515	deoxyribonuclease V activity
I3J16_RS02980	COG0488	(ABC) transporter
I3J16_RS02985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J16_RS03025	COG1793	dna ligase
I3J16_RS03080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J16_RS03120	COG3012	SEC-C Motif Domain Protein
I3J16_RS03150	COG1609	Transcriptional regulator
I3J16_RS03155	COG3345	alpha-galactosidase
I3J16_RS03245	COG0475	glutathione-regulated potassium exporter activity
I3J16_RS03260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J16_RS03265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J16_RS03270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J16_RS03360	COG1082	Xylose isomerase domain protein TIM barrel
I3J16_RS03365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J16_RS03385	COG0673	inositol 2-dehydrogenase activity
I3J16_RS03390	COG4213	ABC transporter substrate-binding protein
I3J16_RS03395	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J16_RS03400	COG1129	ABC transporter
I3J16_RS03405	COG1940	carbohydrate kinase activity
I3J16_RS03415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J16_RS03420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J16_RS03440	COG1595	DNA-templated transcription, initiation
I3J16_RS03450	COG3250	beta-galactosidase activity
I3J16_RS03460	COG3250	beta-galactosidase activity
I3J16_RS03475	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J16_RS03480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J16_RS03490	COG0656	L-ascorbic acid biosynthetic process
I3J16_RS03500	COG1793	dna ligase
I3J16_RS03550	COG1063	alcohol dehydrogenase
I3J16_RS03620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J16_RS03625	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J16_RS03635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J16_RS03640	COG2362	D-Aminopeptidase
I3J16_RS03695	COG0604	alcohol dehydrogenase
I3J16_RS03700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS03700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS03715	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS03720	COG0688	phosphatidylethanolamine metabolic process
I3J16_RS03730	COG1929	Belongs to the glycerate kinase type-1 family
I3J16_RS03745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J16_RS03750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J16_RS03760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J16_RS03775	COG0483	inositol monophosphate 1-phosphatase activity
I3J16_RS03780	COG0095	Lipoate-protein ligase
I3J16_RS03790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J16_RS03795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J16_RS03825	COG0405	Gamma-glutamyltransferase
I3J16_RS03835	COG0765	amino acid transport
I3J16_RS03840	COG0765	amino acid transport
I3J16_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J16_RS03850	COG1126	abc transporter atp-binding protein
I3J16_RS03870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J16_RS03880	COG1940	carbohydrate kinase activity
I3J16_RS03900	COG2188	Transcriptional regulator
I3J16_RS03905	COG0673	inositol 2-dehydrogenase activity
I3J16_RS03915	COG2197	response regulator
I3J16_RS03920	COG4585	Histidine kinase
I3J16_RS03935	COG4266	Belongs to the allantoicase family
I3J16_RS03940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J16_RS03945	COG1414	Transcriptional regulator
I3J16_RS03960	COG0746	molybdenum cofactor guanylyltransferase activity
I3J16_RS03970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J16_RS03985	COG1288	antiporter activity
I3J16_RS04015	COG2351	hydroxyisourate hydrolase activity
I3J16_RS04040	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS04045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J16_RS04050	COG2197	response regulator
I3J16_RS04065	COG3409	Peptidoglycan-binding domain 1 protein
I3J16_RS04085	COG1404	Belongs to the peptidase S8 family
I3J16_RS04100	COG0243	molybdopterin cofactor binding
I3J16_RS04135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J16_RS04150	COG2345	Transcriptional regulator
I3J16_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS04170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS04185	COG2197	response regulator
I3J16_RS04190	COG1132	(ABC) transporter
I3J16_RS04195	COG1132	(ABC) transporter
I3J16_RS04205	COG0515	serine threonine protein kinase
I3J16_RS04215	COG1609	Transcriptional regulator
I3J16_RS04260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J16_RS04275	COG3835	regulator
I3J16_RS04280	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J16_RS04290	COG3842	ATPase activity
I3J16_RS04305	COG1802	Transcriptional regulator
I3J16_RS04325	COG0028	Belongs to the TPP enzyme family
I3J16_RS04355	COG1162	GTPase activity
I3J16_RS04380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J16_RS04410	COG3290	protein histidine kinase activity
I3J16_RS04450	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS04455	COG3284	Transcriptional regulator
I3J16_RS04475	COG0175	sulfate reduction
I3J16_RS04480	COG0529	Catalyzes the synthesis of activated sulfate
I3J16_RS04500	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J16_RS04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J16_RS04540	COG1175	transmembrane transport
I3J16_RS04615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J16_RS04620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J16_RS04645	COG1764	response to oxidative stress
I3J16_RS04650	COG1846	Transcriptional regulator
I3J16_RS04670	COG3220	belongs to the UPF0276 family
I3J16_RS04685	COG0596	Alpha beta hydrolase
I3J16_RS04690	COG3253	May function as heme-dependent peroxidase
I3J16_RS04695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J16_RS04705	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J16_RS04710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J16_RS04730	COG0183	Belongs to the thiolase family
I3J16_RS04735	COG1024	Enoyl-CoA hydratase
I3J16_RS04735	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J16_RS04745	COG0531	amino acid
I3J16_RS04750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J16_RS04755	COG4214	carbohydrate transport
I3J16_RS04765	COG4213	ABC transporter substrate-binding protein
I3J16_RS04770	COG1940	carbohydrate kinase activity
I3J16_RS04775	COG0395	ABC-type sugar transport system, permease component
I3J16_RS04780	COG1175	transmembrane transport
I3J16_RS04785	COG1653	transport
I3J16_RS04795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J16_RS04800	COG1522	sequence-specific DNA binding
I3J16_RS04820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J16_RS04865	COG1024	Enoyl-CoA hydratase
I3J16_RS04870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J16_RS04880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J16_RS04900	COG2040	homocysteine
I3J16_RS04920	COG1799	cell septum assembly
I3J16_RS04940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J16_RS04960	COG4689	acetoacetate decarboxylase
I3J16_RS04990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J16_RS05005	COG0745	RESPONSE REGULATOR receiver
I3J16_RS05010	COG2205	protein histidine kinase activity
I3J16_RS05035	COG0756	dUTP diphosphatase activity
I3J16_RS05045	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J16_RS05045	COG1136	(ABC) transporter
I3J16_RS05080	COG1136	(ABC) transporter
I3J16_RS05080	COG0577	efflux transmembrane transporter activity
I3J16_RS05090	COG0569	domain protein
I3J16_RS05095	COG0531	amino acid
I3J16_RS05100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J16_RS05110	COG0483	inositol monophosphate 1-phosphatase activity
I3J16_RS05115	COG2264	protein methyltransferase activity
I3J16_RS05130	COG0494	nUDIX hydrolase
I3J16_RS05160	COG0142	geranyltranstransferase activity
I3J16_RS05215	COG2409	Drug exporters of the RND superfamily
I3J16_RS05235	COG3903	Transcriptional regulator
I3J16_RS05235	COG3629	intracellular signal transduction
I3J16_RS05245	COG2264	protein methyltransferase activity
I3J16_RS05305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J16_RS05310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS05315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J16_RS05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J16_RS05340	COG0702	epimerase
I3J16_RS05355	COG1435	thymidine kinase activity
I3J16_RS05370	COG1042	CoA-binding domain protein
I3J16_RS05370	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J16_RS05370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J16_RS05375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J16_RS05380	COG1802	Transcriptional regulator
I3J16_RS05385	COG0739	heme binding
I3J16_RS05385	COG1196	nuclear chromosome segregation
I3J16_RS05385	COG0741	lytic transglycosylase activity
I3J16_RS05395	COG0612	Peptidase, M16
I3J16_RS05400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J16_RS05410	COG0372	Belongs to the citrate synthase family
I3J16_RS05420	COG3290	protein histidine kinase activity
I3J16_RS05425	COG4565	transcriptional regulatory protein
I3J16_RS05430	COG0187	DNA topoisomerase II activity
I3J16_RS05445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J16_RS05450	COG2186	Transcriptional regulator
I3J16_RS05455	COG1131	(ABC) transporter
I3J16_RS05485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J16_RS05510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J16_RS05515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J16_RS05520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J16_RS05550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J16_RS05560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J16_RS05565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J16_RS05575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J16_RS05595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J16_RS05600	COG2358	TRAP transporter, solute receptor (TAXI family
I3J16_RS05605	COG2205	protein histidine kinase activity
I3J16_RS05610	COG0745	RESPONSE REGULATOR receiver
I3J16_RS05615	COG1126	abc transporter atp-binding protein
I3J16_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J16_RS05625	COG0765	amino acid transport
I3J16_RS05630	COG0765	amino acid transport
I3J16_RS05635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J16_RS05650	COG2137	regulation of response to DNA damage stimulus
I3J16_RS05690	COG1201	RNA secondary structure unwinding
I3J16_RS05695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J16_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS05705	COG0783	Belongs to the Dps family
I3J16_RS05710	COG1396	sequence-specific DNA binding
I3J16_RS05715	COG1546	Belongs to the CinA family
I3J16_RS05715	COG1058	Belongs to the CinA family
I3J16_RS05725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J16_RS05735	COG1674	ftsk spoiiie
I3J16_RS05745	COG0784	Response regulator, receiver
I3J16_RS05745	COG5002	protein histidine kinase activity
I3J16_RS05750	COG2770	Histidine kinase
I3J16_RS05750	COG2208	phosphoserine phosphatase activity
I3J16_RS05775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J16_RS05780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J16_RS05785	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J16_RS05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J16_RS05810	COG0612	Peptidase, M16
I3J16_RS05815	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J16_RS05820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J16_RS05830	COG1674	ftsk spoiiie
I3J16_RS05845	COG1404	Belongs to the peptidase S8 family
I3J16_RS05860	COG1404	Belongs to the peptidase S8 family
I3J16_RS05865	COG3266	domain, Protein
I3J16_RS05885	COG0455	bacterial-type flagellum organization
I3J16_RS05890	COG0747	negative chemotaxis
I3J16_RS05895	COG0601	transmembrane transport
I3J16_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS05920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J16_RS05925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J16_RS05935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J16_RS05950	COG0779	Required for maturation of 30S ribosomal subunits
I3J16_RS05970	COG0442	prolyl-tRNA aminoacylation
I3J16_RS05985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J16_RS05990	COG0750	zinc metalloprotease
I3J16_RS05995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J16_RS06010	COG2508	Transcriptional regulator
I3J16_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J16_RS06045	COG1177	transmembrane transport
I3J16_RS06050	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J16_RS06055	COG3842	ATPase activity
I3J16_RS06080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J16_RS06095	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS06105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS06110	COG1136	(ABC) transporter
I3J16_RS06125	COG3842	ATPase activity
I3J16_RS06140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J16_RS06145	COG0575	Belongs to the CDS family
I3J16_RS06150	COG0233	cytoplasmic translational termination
I3J16_RS06155	COG0528	UMP kinase activity
I3J16_RS06160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J16_RS06165	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J16_RS06180	COG1191	sigma factor activity
I3J16_RS06195	COG0792	nuclease activity
I3J16_RS06205	COG0681	Belongs to the peptidase S26 family
I3J16_RS06220	COG0681	Belongs to the peptidase S26 family
I3J16_RS06225	COG0335	large ribosomal subunit rRNA binding
I3J16_RS06230	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J16_RS06235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J16_RS06240	COG1837	Belongs to the UPF0109 family
I3J16_RS06245	COG0228	four-way junction DNA binding
I3J16_RS06255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J16_RS06265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J16_RS06295	COG4552	Acetyltransferase involved in intracellular survival and related
I3J16_RS06300	COG0477	Major facilitator Superfamily
I3J16_RS06305	COG1196	nuclear chromosome segregation
I3J16_RS06320	COG1254	Belongs to the acylphosphatase family
I3J16_RS06325	COG2340	Cysteine-rich secretory protein family
I3J16_RS06330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J16_RS06335	COG0571	ribonuclease III activity
I3J16_RS06340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J16_RS06355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J16_RS06360	COG0742	ribosomal rna small subunit methyltransferase
I3J16_RS06370	COG1461	Dihydroxyacetone kinase
I3J16_RS06375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J16_RS06380	COG0351	phosphomethylpyrimidine kinase
I3J16_RS06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J16_RS06400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J16_RS06410	COG1920	GTP binding
I3J16_RS06420	COG0776	regulation of translation
I3J16_RS06430	COG0066	3-isopropylmalate dehydratase activity
I3J16_RS06435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J16_RS06440	COG1414	Transcriptional regulator
I3J16_RS06470	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J16_RS06475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J16_RS06480	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J16_RS06490	COG5002	protein histidine kinase activity
I3J16_RS06495	COG2018	Roadblock/LC7 domain
I3J16_RS06515	COG2018	Roadblock/LC7 domain
I3J16_RS06535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J16_RS06555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J16_RS06565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J16_RS06570	COG0477	Major facilitator Superfamily
I3J16_RS06580	COG2957	Belongs to the agmatine deiminase family
I3J16_RS06585	COG0804	urea catabolic process
I3J16_RS06595	COG0831	urea catabolic process
I3J16_RS06595	COG0832	Belongs to the urease beta subunit family
I3J16_RS06620	COG0300	oxidoreductase activity
I3J16_RS06630	COG3321	synthase
I3J16_RS06630	COG0604	alcohol dehydrogenase
I3J16_RS06645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J16_RS06650	COG0473	3-isopropylmalate dehydrogenase activity
I3J16_RS06665	COG1082	Xylose isomerase domain protein TIM barrel
I3J16_RS06725	COG0640	Transcriptional regulator
I3J16_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS06735	COG0506	proline dehydrogenase activity
I3J16_RS06740	COG2508	Transcriptional regulator
I3J16_RS06740	COG2508	Transcriptional regulator
I3J16_RS06745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J16_RS06750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J16_RS06755	COG0440	acetolactate synthase activity
I3J16_RS06775	COG0667	Aldo Keto reductase
I3J16_RS06780	COG2133	pyrroloquinoline quinone binding
I3J16_RS06790	COG1672	PFAM Archaeal ATPase
I3J16_RS06790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J16_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J16_RS06810	COG2409	Drug exporters of the RND superfamily
I3J16_RS06820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J16_RS06830	COG0154	amidase activity
I3J16_RS06835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J16_RS06845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J16_RS06855	COG4221	oxidoreductase activity
I3J16_RS06860	COG1611	Belongs to the LOG family
I3J16_RS06870	COG0482	sulfurtransferase activity
I3J16_RS06895	COG2860	membrane
I3J16_RS06900	COG4608	Belongs to the ABC transporter superfamily
I3J16_RS06905	COG0444	Belongs to the ABC transporter superfamily
I3J16_RS06910	COG0601	transmembrane transport
I3J16_RS06915	COG0747	negative chemotaxis
I3J16_RS06920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS06940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J16_RS06945	COG0509	glycine decarboxylation via glycine cleavage system
I3J16_RS06950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J16_RS06955	COG1760	l-serine dehydratase
I3J16_RS06965	COG2856	Zn peptidase
I3J16_RS07095	COG1024	Enoyl-CoA hydratase
I3J16_RS07110	COG1132	(ABC) transporter
I3J16_RS07115	COG1132	(ABC) transporter
I3J16_RS07125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J16_RS07160	COG2197	response regulator
I3J16_RS07165	COG4585	Histidine kinase
I3J16_RS07175	COG0058	SHG alpha-glucan phosphorylase activity
I3J16_RS07180	COG0366	Alpha amylase catalytic
I3J16_RS07185	COG0366	Alpha amylase catalytic
I3J16_RS07195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J16_RS07210	COG1301	dicarboxylic acid transport
I3J16_RS07215	COG3290	protein histidine kinase activity
I3J16_RS07220	COG4565	transcriptional regulatory protein
I3J16_RS07225	COG0181	hydroxymethylbilane synthase activity
I3J16_RS07255	COG1175	transmembrane transport
I3J16_RS07265	COG0205	6-phosphofructokinase activity
I3J16_RS07270	COG0280	phosphate acetyltransferase
I3J16_RS07270	COG0857	belongs to the CobB CobQ family
I3J16_RS07275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J16_RS07310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS07310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS07355	COG0745	RESPONSE REGULATOR receiver
I3J16_RS07370	COG0183	Belongs to the thiolase family
I3J16_RS07390	COG1131	(ABC) transporter
I3J16_RS07425	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J16_RS07440	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J16_RS07455	COG4585	Histidine kinase
I3J16_RS07460	COG2197	response regulator
I3J16_RS07470	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J16_RS07490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J16_RS07520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J16_RS07530	COG0494	nUDIX hydrolase
I3J16_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J16_RS07550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J16_RS07555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J16_RS07560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J16_RS07565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J16_RS07570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J16_RS07575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J16_RS07595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J16_RS07600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J16_RS07610	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J16_RS07615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J16_RS07620	COG0254	rRNA binding
I3J16_RS07625	COG1316	TRANSCRIPTIONal
I3J16_RS07640	COG0083	homoserine kinase activity
I3J16_RS07645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J16_RS07650	COG0460	homoserine dehydrogenase
I3J16_RS07655	COG0019	diaminopimelate decarboxylase activity
I3J16_RS07660	COG0018	arginyl-trna synthetase
I3J16_RS07800	COG2367	Beta-lactamase
I3J16_RS07805	COG1686	Belongs to the peptidase S11 family
I3J16_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS07820	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J16_RS07825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J16_RS07845	COG2192	nodulation
I3J16_RS07855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J16_RS07865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J16_RS07875	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J16_RS07885	COG0768	penicillin binding
I3J16_RS07895	COG0367	asparagine synthase
I3J16_RS07900	COG0010	Belongs to the arginase family
I3J16_RS07905	COG2175	clavaminate synthase activity
I3J16_RS07945	COG0697	spore germination
I3J16_RS07950	COG0456	acetyltransferase
I3J16_RS07955	COG0747	negative chemotaxis
I3J16_RS07965	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J16_RS07970	COG0768	penicillin binding
I3J16_RS07975	COG0768	penicillin binding
I3J16_RS07980	COG2124	cytochrome p450
I3J16_RS07990	COG2205	protein histidine kinase activity
I3J16_RS07995	COG0745	RESPONSE REGULATOR receiver
I3J16_RS08015	COG2072	flavoprotein involved in K transport
I3J16_RS08020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J16_RS08025	COG3285	dna ligase
I3J16_RS08025	COG1793	dna ligase
I3J16_RS08030	COG1793	dna ligase
I3J16_RS08085	COG0768	penicillin binding
I3J16_RS08115	COG2318	DinB family
I3J16_RS08150	COG2205	protein histidine kinase activity
I3J16_RS08170	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J16_RS08175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J16_RS08185	COG0745	RESPONSE REGULATOR receiver
I3J16_RS08190	COG2205	protein histidine kinase activity
I3J16_RS08195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J16_RS08195	COG0567	Dehydrogenase, E1 component
I3J16_RS08205	COG2255	four-way junction helicase activity
I3J16_RS08240	COG0604	alcohol dehydrogenase
I3J16_RS08260	COG1126	abc transporter atp-binding protein
I3J16_RS08265	COG4106	trans-aconitate 2-methyltransferase activity
I3J16_RS08285	COG0494	nUDIX hydrolase
I3J16_RS08295	COG5640	endopeptidase activity
I3J16_RS08315	COG0142	geranyltranstransferase activity
I3J16_RS08350	COG1597	lipid kinase activity
I3J16_RS08365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J16_RS08370	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J16_RS08375	COG0395	ABC-type sugar transport system, permease component
I3J16_RS08380	COG1175	transmembrane transport
I3J16_RS08385	COG2182	Extracellular solute-binding protein
I3J16_RS08390	COG2188	Transcriptional regulator
I3J16_RS08415	COG0242	peptide deformylase activity
I3J16_RS08435	COG5662	AntiSigma factor
I3J16_RS08440	COG1595	DNA-templated transcription, initiation
I3J16_RS08450	COG2135	peptidase activity
I3J16_RS08460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J16_RS08470	COG2076	Multidrug Resistance protein
I3J16_RS08480	COG0483	inositol monophosphate 1-phosphatase activity
I3J16_RS08490	COG0753	catalase activity
I3J16_RS08515	COG1615	UPF0182 protein
I3J16_RS08525	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J16_RS08565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J16_RS08605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J16_RS08660	COG0601	transmembrane transport
I3J16_RS08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS08670	COG0747	negative chemotaxis
I3J16_RS08680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J16_RS08680	COG0596	Alpha beta hydrolase
I3J16_RS08710	COG0513	Belongs to the DEAD box helicase family
I3J16_RS08735	COG1432	Conserved Protein
I3J16_RS08745	COG2095	MarC family integral membrane protein
I3J16_RS08765	COG0598	Magnesium transport protein CorA
I3J16_RS08800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J16_RS08805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J16_RS08815	COG1595	DNA-templated transcription, initiation
I3J16_RS08830	COG1024	Enoyl-CoA hydratase
I3J16_RS08835	COG0519	Catalyzes the synthesis of GMP from XMP
I3J16_RS08845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J16_RS08850	COG1611	Belongs to the LOG family
I3J16_RS08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J16_RS08895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J16_RS08910	COG4608	Belongs to the ABC transporter superfamily
I3J16_RS08915	COG0444	Belongs to the ABC transporter superfamily
I3J16_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS08925	COG0601	transmembrane transport
I3J16_RS08940	COG4608	Belongs to the ABC transporter superfamily
I3J16_RS08945	COG0444	Belongs to the ABC transporter superfamily
I3J16_RS08955	COG4166	transmembrane transport
I3J16_RS08960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J16_RS08965	COG1217	gtp-binding protein TYPA
I3J16_RS08985	COG1053	succinate dehydrogenase
I3J16_RS09035	COG0012	GTP binding
I3J16_RS09050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J16_RS09055	COG0531	amino acid
I3J16_RS09060	COG1570	exodeoxyribonuclease VII activity
I3J16_RS09065	COG1722	exodeoxyribonuclease VII activity
I3J16_RS09070	COG0778	Nitroreductase
I3J16_RS09095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J16_RS09095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J16_RS09105	COG0114	fumarate hydratase activity
I3J16_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J16_RS09145	COG1136	(ABC) transporter
I3J16_RS09160	COG0450	alkyl hydroperoxide reductase
I3J16_RS09165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J16_RS09180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J16_RS09185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J16_RS09190	COG0667	Aldo Keto reductase
I3J16_RS09215	COG2885	chlorophyll binding
I3J16_RS09235	COG2197	response regulator
I3J16_RS09240	COG4585	Histidine kinase
I3J16_RS09270	COG2894	cell division
I3J16_RS09295	COG2610	gluconate transmembrane transporter activity
I3J16_RS09300	COG0251	oxidation-reduction process
I3J16_RS09305	COG1414	Transcriptional regulator
I3J16_RS09320	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J16_RS09380	COG0492	ferredoxin-NADP+ reductase activity
I3J16_RS09415	COG0728	peptidoglycan biosynthetic process
I3J16_RS09425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J16_RS09430	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS09470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J16_RS09480	COG1309	transcriptional regulator
I3J16_RS09485	COG1331	Highly conserved protein containing a thioredoxin domain
I3J16_RS09515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J16_RS09525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J16_RS09535	COG2188	Transcriptional regulator
I3J16_RS09555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J16_RS09595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J16_RS09615	COG1064	alcohol dehydrogenase
I3J16_RS09630	COG2986	histidine ammonia-lyase
I3J16_RS09640	COG1024	Enoyl-CoA hydratase
I3J16_RS09655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J16_RS09665	COG0424	maF-like protein
I3J16_RS09670	COG4770	biotin carboxylase activity
I3J16_RS09700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J16_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS09750	COG1595	DNA-templated transcription, initiation
I3J16_RS09755	COG0745	RESPONSE REGULATOR receiver
I3J16_RS09760	COG2205	protein histidine kinase activity
I3J16_RS09785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J16_RS09800	COG0583	DNA-binding transcription factor activity
I3J16_RS09805	COG2814	Major facilitator Superfamily
I3J16_RS09840	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J16_RS09845	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J16_RS09850	COG3845	ABC transporter
I3J16_RS09855	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J16_RS09860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J16_RS09860	COG1473	amidohydrolase
I3J16_RS09870	COG2089	acid synthase
I3J16_RS09875	COG1083	cytidylyl-transferase
I3J16_RS09885	COG1216	Glycosyl transferase, family 2
I3J16_RS09900	COG0516	GMP reductase activity
I3J16_RS09900	COG0517	IMP dehydrogenase activity
I3J16_RS09915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS09915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS09930	COG1595	DNA-templated transcription, initiation
I3J16_RS09940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J16_RS09945	COG2009	succinate dehydrogenase
I3J16_RS09955	COG1053	succinate dehydrogenase
I3J16_RS09960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J16_RS09970	COG1408	metallophosphoesterase
I3J16_RS09980	COG1686	Belongs to the peptidase S11 family
I3J16_RS09985	COG1295	ribonuclease BN
I3J16_RS09990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J16_RS10015	COG0180	Tryptophanyl-tRNA synthetase
I3J16_RS10020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J16_RS10025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J16_RS10030	COG0754	glutathionylspermidine amidase activity
I3J16_RS10040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J16_RS10080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J16_RS10090	COG0039	L-malate dehydrogenase activity
I3J16_RS10105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J16_RS10120	COG0138	bifunctional purine biosynthesis protein purh
I3J16_RS10150	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J16_RS10155	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J16_RS10165	COG0714	Associated with various cellular activities
I3J16_RS10180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS10180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J16_RS10190	COG0739	heme binding
I3J16_RS10210	COG2197	response regulator
I3J16_RS10235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J16_RS10235	COG0519	Catalyzes the synthesis of GMP from XMP
I3J16_RS10255	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS10275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J16_RS10285	COG0516	GMP reductase activity
I3J16_RS10295	COG1595	DNA-templated transcription, initiation
I3J16_RS10300	COG2197	response regulator
I3J16_RS10310	COG0583	DNA-binding transcription factor activity
I3J16_RS10325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J16_RS10330	COG0459	protein refolding
I3J16_RS10335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J16_RS10340	COG0726	polysaccharide deacetylase
I3J16_RS10350	COG4941	Belongs to the sigma-70 factor family
I3J16_RS10375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J16_RS10400	COG0802	atpase or kinase
I3J16_RS10410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J16_RS10430	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J16_RS10435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J16_RS10440	COG1072	(Pantothenic acid kinase))
I3J16_RS10445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J16_RS10450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J16_RS10455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J16_RS10460	COG0488	(ABC) transporter
I3J16_RS10470	COG0101	tRNA pseudouridine synthase activity
I3J16_RS10475	COG0203	ribosomal protein L17
I3J16_RS10480	COG0202	RNA polymerase activity
I3J16_RS10485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J16_RS10490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J16_RS10495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J16_RS10500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J16_RS10510	COG0563	adenylate kinase activity
I3J16_RS10520	COG0200	Binds to the 23S rRNA
I3J16_RS10525	COG1841	ribosomal large subunit assembly
I3J16_RS10530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J16_RS10535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J16_RS10540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J16_RS10545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J16_RS10550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J16_RS10555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J16_RS10560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J16_RS10565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J16_RS10570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J16_RS10575	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J16_RS10580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J16_RS10585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J16_RS10590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J16_RS10595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J16_RS10600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J16_RS10605	COG0089	rRNA binding
I3J16_RS10610	COG0088	Forms part of the polypeptide exit tunnel
I3J16_RS10615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J16_RS10620	COG0051	transcription antitermination factor activity, RNA binding
I3J16_RS10630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J16_RS10635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J16_RS10640	COG0049	tRNA binding
I3J16_RS10645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J16_RS10650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J16_RS10655	COG0085	RNA polymerase activity
I3J16_RS10660	COG0222	ribosome binding
I3J16_RS10665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J16_RS10670	COG0081	regulation of translation
I3J16_RS10675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J16_RS10685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J16_RS10695	COG0436	Aminotransferase
I3J16_RS10700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J16_RS10705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J16_RS10715	COG2030	dehydratase
I3J16_RS10720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J16_RS10740	COG0702	epimerase
I3J16_RS10760	COG1666	GTP binding
I3J16_RS10765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J16_RS10775	COG3304	Inner membrane component domain
I3J16_RS10780	COG0501	Belongs to the peptidase M48B family
I3J16_RS10785	COG1007	ATP synthesis coupled electron transport
I3J16_RS10800	COG0713	ATP synthesis coupled electron transport
I3J16_RS10805	COG0839	Belongs to the complex I subunit 6 family
I3J16_RS10810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J16_RS10820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10835	COG4585	Histidine kinase
I3J16_RS10850	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J16_RS10850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J16_RS10855	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J16_RS10880	COG1733	regulation of RNA biosynthetic process
I3J16_RS10895	COG2234	aminopeptidase activity
I3J16_RS10895	COG4935	Belongs to the peptidase S8 family
I3J16_RS10920	COG0142	geranyltranstransferase activity
I3J16_RS10925	COG2936	dipeptidyl-peptidase activity
I3J16_RS10930	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J16_RS10935	COG1007	ATP synthesis coupled electron transport
I3J16_RS10945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J16_RS10950	COG0713	ATP synthesis coupled electron transport
I3J16_RS10955	COG0839	Belongs to the complex I subunit 6 family
I3J16_RS10960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J16_RS10970	COG1034	ATP synthesis coupled electron transport
I3J16_RS10975	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J16_RS10985	COG0649	NAD binding
I3J16_RS10990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS10995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J16_RS11025	COG2226	methyltransferase
I3J16_RS11035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J16_RS11040	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J16_RS11045	COG1278	Cold shock
I3J16_RS11050	COG1823	symporter activity
I3J16_RS11070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J16_RS11080	COG0163	prenyltransferase activity
I3J16_RS11085	COG0109	protoheme IX farnesyltransferase activity
I3J16_RS11090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J16_RS11100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J16_RS11105	COG1333	cytochrome c biogenesis protein
I3J16_RS11110	COG0785	Cytochrome C biogenesis protein
I3J16_RS11115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J16_RS11120	COG0406	alpha-ribazole phosphatase activity
I3J16_RS11125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J16_RS11140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J16_RS11150	COG1742	UPF0060 membrane protein
I3J16_RS11165	COG0402	S-adenosylhomocysteine deaminase activity
I3J16_RS11170	COG1690	Belongs to the RtcB family
I3J16_RS11210	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J16_RS11215	COG0626	cystathionine gamma-synthase activity
I3J16_RS11230	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J16_RS11235	COG0018	arginyl-trna synthetase
I3J16_RS11255	COG0113	porphobilinogen synthase activity
I3J16_RS11360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J16_RS11365	COG0596	Alpha beta hydrolase
I3J16_RS11390	COG1136	(ABC) transporter
I3J16_RS11465	COG1725	Transcriptional regulator
I3J16_RS11485	COG1309	transcriptional regulator
I3J16_RS11505	COG0702	epimerase
I3J16_RS11515	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS11540	COG0259	pyridoxamine-phosphate oxidase activity
I3J16_RS11555	COG2072	flavoprotein involved in K transport
I3J16_RS11565	COG1024	Enoyl-CoA hydratase
I3J16_RS11575	COG0456	acetyltransferase
I3J16_RS11580	COG2814	Major facilitator Superfamily
I3J16_RS11580	COG0477	Major facilitator Superfamily
I3J16_RS11585	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J16_RS11600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J16_RS11605	COG2271	Major facilitator Superfamily
I3J16_RS11610	COG4977	sequence-specific DNA binding
I3J16_RS11610	COG1917	Cupin 2, conserved barrel domain protein
I3J16_RS11620	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS11640	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS11645	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS11655	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS11660	COG3397	chitin binding
I3J16_RS11730	COG2945	thiolester hydrolase activity
I3J16_RS11730	COG0596	Alpha beta hydrolase
I3J16_RS11740	COG4821	SIS domain
I3J16_RS11750	COG0259	pyridoxamine-phosphate oxidase activity
I3J16_RS11770	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS11785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J16_RS11855	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS11900	COG0726	polysaccharide deacetylase
I3J16_RS11930	COG0577	efflux transmembrane transporter activity
I3J16_RS11935	COG0577	efflux transmembrane transporter activity
I3J16_RS11935	COG1136	(ABC) transporter
I3J16_RS11970	COG0583	DNA-binding transcription factor activity
I3J16_RS11985	COG2205	protein histidine kinase activity
I3J16_RS11990	COG0745	RESPONSE REGULATOR receiver
I3J16_RS12005	COG0277	FAD linked oxidase domain protein
I3J16_RS12005	COG0247	lactate metabolic process
I3J16_RS12015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J16_RS12055	COG0463	Glycosyl transferase, family 2
I3J16_RS12065	COG3903	Transcriptional regulator
I3J16_RS12065	COG3629	intracellular signal transduction
I3J16_RS12080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J16_RS12120	COG1122	ATPase activity
I3J16_RS12140	COG0667	Aldo Keto reductase
I3J16_RS12175	COG2252	PERMEase
I3J16_RS12185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J16_RS12205	COG2814	Major facilitator Superfamily
I3J16_RS12215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J16_RS12220	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J16_RS12225	COG1278	Cold shock
I3J16_RS12260	COG1061	Type III restriction enzyme res subunit
I3J16_RS12270	COG3973	AAA domain
I3J16_RS12285	COG1595	DNA-templated transcription, initiation
I3J16_RS12360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J16_RS12365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J16_RS12375	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS12380	COG1605	Chorismate mutase
I3J16_RS12400	COG2197	response regulator
I3J16_RS12420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J16_RS12445	COG0191	fructose-bisphosphate aldolase activity
I3J16_RS12450	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J16_RS12465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J16_RS12470	COG2182	Extracellular solute-binding protein
I3J16_RS12495	COG0463	Glycosyl transferase, family 2
I3J16_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J16_RS12575	COG3842	ATPase activity
I3J16_RS12585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J16_RS12595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J16_RS12600	COG0215	cysteine-tRNA ligase activity
I3J16_RS12610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J16_RS12615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J16_RS12620	COG1329	Transcriptional regulator
I3J16_RS12635	COG5002	protein histidine kinase activity
I3J16_RS12650	COG0588	phosphoglycerate mutase activity
I3J16_RS12655	COG2211	Major facilitator Superfamily
I3J16_RS12680	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS12740	COG1490	D-aminoacyl-tRNA deacylase activity
I3J16_RS12755	COG3485	protocatechuate 3,4-dioxygenase
I3J16_RS12780	COG1309	transcriptional regulator
I3J16_RS12800	COG0745	RESPONSE REGULATOR receiver
I3J16_RS12805	COG1609	Transcriptional regulator
I3J16_RS12820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J16_RS12835	COG2188	Transcriptional regulator
I3J16_RS12845	COG4085	toxin activity
I3J16_RS12845	COG1525	nuclease
I3J16_RS12845	COG0737	Belongs to the 5'-nucleotidase family
I3J16_RS12865	COG0456	acetyltransferase
I3J16_RS12870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J16_RS12880	COG0406	alpha-ribazole phosphatase activity
I3J16_RS12880	COG0494	nUDIX hydrolase
I3J16_RS12905	COG0306	phosphate transporter
I3J16_RS12915	COG1937	Protein conserved in bacteria
I3J16_RS12935	COG0671	phosphoesterase, PA-phosphatase related
I3J16_RS12940	COG1196	nuclear chromosome segregation
I3J16_RS12940	COG0739	heme binding
I3J16_RS12940	COG0741	lytic transglycosylase activity
I3J16_RS13035	COG0579	oxidoreductase
I3J16_RS13040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J16_RS13050	COG0739	heme binding
I3J16_RS13050	COG0741	lytic transglycosylase activity
I3J16_RS13050	COG1196	nuclear chromosome segregation
I3J16_RS13105	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J16_RS13115	COG0513	Belongs to the DEAD box helicase family
I3J16_RS13125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J16_RS13130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J16_RS13165	COG0785	Cytochrome C biogenesis protein
I3J16_RS13170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J16_RS13170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J16_RS13180	COG1643	Atp-dependent helicase
I3J16_RS13215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J16_RS13245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J16_RS13250	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J16_RS13255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J16_RS13290	COG2197	response regulator
I3J16_RS13300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J16_RS13315	COG0151	Belongs to the GarS family
I3J16_RS13340	COG0017	Asparaginyl-tRNA synthetase
I3J16_RS13345	COG1051	belongs to the nudix hydrolase family
I3J16_RS13355	COG0105	UTP biosynthetic process
I3J16_RS13395	COG2826	transposase and inactivated derivatives, IS30 family
I3J16_RS13425	COG3903	Transcriptional regulator
I3J16_RS13425	COG3629	intracellular signal transduction
I3J16_RS13490	COG0477	Major facilitator Superfamily
I3J16_RS13520	COG2234	aminopeptidase activity
I3J16_RS13525	COG0433	COG0433 Predicted ATPase
I3J16_RS13540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J16_RS13585	COG1191	sigma factor activity
I3J16_RS13590	COG1191	sigma factor activity
I3J16_RS13640	COG2304	oxidoreductase activity
I3J16_RS13645	COG2205	protein histidine kinase activity
I3J16_RS13650	COG0745	RESPONSE REGULATOR receiver
I3J16_RS13655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J16_RS13675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J16_RS13700	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS13710	COG1362	aminopeptidase activity
I3J16_RS13730	COG2271	Major facilitator Superfamily
I3J16_RS13745	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J16_RS13750	COG0022	dehydrogenase e1 component
I3J16_RS13775	COG0515	serine threonine protein kinase
I3J16_RS13780	COG0515	serine threonine protein kinase
I3J16_RS13795	COG1136	(ABC) transporter
I3J16_RS13795	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J16_RS13825	COG0303	'Molybdopterin
I3J16_RS13850	COG1522	sequence-specific DNA binding
I3J16_RS13855	COG1309	transcriptional regulator
I3J16_RS13860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J16_RS13885	COG3396	Phenylacetate-CoA oxygenase
I3J16_RS13890	COG3460	Phenylacetate-CoA oxygenase
I3J16_RS13895	COG3396	Phenylacetate-CoA oxygenase
I3J16_RS13900	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J16_RS13905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J16_RS13910	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS13915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J16_RS13930	COG2197	response regulator
I3J16_RS13935	COG4585	Histidine kinase
I3J16_RS13960	COG1136	(ABC) transporter
I3J16_RS13960	COG0577	efflux transmembrane transporter activity
I3J16_RS13965	COG0577	efflux transmembrane transporter activity
I3J16_RS13965	COG1136	(ABC) transporter
I3J16_RS13975	COG1716	ATPase activity
I3J16_RS13980	COG1716	ATPase activity
I3J16_RS13995	COG0768	penicillin binding
I3J16_RS14000	COG0515	serine threonine protein kinase
I3J16_RS14005	COG3764	Sortase (surface protein transpeptidase)
I3J16_RS14010	COG3764	Sortase (surface protein transpeptidase)
I3J16_RS14025	COG3764	Sortase (surface protein transpeptidase)
I3J16_RS14040	COG0705	Rhomboid family
I3J16_RS14040	COG0457	Tetratricopeptide repeat
I3J16_RS14070	COG1446	asparaginase
I3J16_RS14075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J16_RS14080	COG1280	lysine exporter protein (LysE YggA)
I3J16_RS14085	COG1672	PFAM Archaeal ATPase
I3J16_RS14085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J16_RS14100	COG0667	Aldo Keto reductase
I3J16_RS14105	COG2175	clavaminate synthase activity
I3J16_RS14110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J16_RS14115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS14120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS14135	COG0515	serine threonine protein kinase
I3J16_RS14155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J16_RS14165	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J16_RS14170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J16_RS14175	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J16_RS14180	COG0592	DNA-directed DNA polymerase activity
I3J16_RS14190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J16_RS14195	COG0594	ribonuclease P activity
I3J16_RS14200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J16_RS14205	COG0706	membrane insertase activity
I3J16_RS14215	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J16_RS14220	COG1192	Involved in chromosome partitioning
I3J16_RS14235	COG3118	belongs to the thioredoxin family
I3J16_RS14240	COG0492	ferredoxin-NADP+ reductase activity
I3J16_RS14250	COG1595	DNA-templated transcription, initiation
I3J16_RS14255	COG2815	serine threonine protein kinase
I3J16_RS14255	COG0515	serine threonine protein kinase
I3J16_RS14270	COG0617	tRNA 3'-terminal CCA addition
I3J16_RS14290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J16_RS14315	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J16_RS14320	COG0629	single-stranded DNA binding
I3J16_RS14325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J16_RS14330	COG0359	binds to the 23S rRNA
I3J16_RS14340	COG0305	Participates in initiation and elongation during chromosome replication
I3J16_RS14375	COG0626	cystathionine gamma-synthase activity
I3J16_RS14380	COG1950	PFAM Membrane protein of
I3J16_RS14385	COG0662	Cupin 2, conserved barrel domain protein
I3J16_RS14405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J16_RS14420	COG1609	Transcriptional regulator
I3J16_RS14425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J16_RS14430	COG1271	oxidase subunit
I3J16_RS14435	COG1294	oxidase, subunit
I3J16_RS14440	COG4988	ABC transporter
I3J16_RS14450	COG0561	phosphatase activity
I3J16_RS14460	COG1131	(ABC) transporter
I3J16_RS14495	COG0561	phosphatase activity
I3J16_RS14500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J16_RS14505	COG0077	Prephenate dehydratase
I3J16_RS14510	COG2837	iron assimilation
I3J16_RS14525	COG1999	signal sequence binding
I3J16_RS14545	COG0006	proline dipeptidase activity
I3J16_RS14575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J16_RS14605	COG0587	DNA-directed DNA polymerase activity
I3J16_RS14610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J16_RS14635	COG1595	DNA-templated transcription, initiation
I3J16_RS14640	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS14645	COG0784	Response regulator, receiver
I3J16_RS14675	COG0745	RESPONSE REGULATOR receiver
I3J16_RS14680	COG0477	Major facilitator Superfamily
I3J16_RS14700	COG0431	NADPH-dependent FMN reductase
I3J16_RS14725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J16_RS14725	COG1672	PFAM Archaeal ATPase
I3J16_RS14730	COG0431	NADPH-dependent FMN reductase
I3J16_RS14760	COG0598	Magnesium transport protein CorA
I3J16_RS14765	COG3345	alpha-galactosidase
I3J16_RS14845	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J16_RS14855	COG2226	methyltransferase
I3J16_RS14860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J16_RS14900	COG2826	transposase and inactivated derivatives, IS30 family
I3J16_RS15005	COG1857	crispr-associated protein
I3J16_RS15025	COG0436	Aminotransferase
I3J16_RS15040	COG2197	response regulator
I3J16_RS15050	COG0577	efflux transmembrane transporter activity
I3J16_RS15110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J16_RS15135	COG3629	intracellular signal transduction
I3J16_RS15135	COG3903	Transcriptional regulator
I3J16_RS15185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J16_RS15195	COG0534	Mate efflux family protein
I3J16_RS15200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J16_RS15205	COG0019	diaminopimelate decarboxylase activity
I3J16_RS15220	COG4166	transmembrane transport
I3J16_RS15225	COG0601	transmembrane transport
I3J16_RS15230	COG4171	peptide transport system, permease
I3J16_RS15245	COG2197	response regulator
I3J16_RS15250	COG4585	Histidine kinase
I3J16_RS15255	COG2409	Drug exporters of the RND superfamily
I3J16_RS15280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J16_RS15290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J16_RS15295	COG0588	phosphoglycerate mutase activity
I3J16_RS15345	COG0717	Belongs to the dCTP deaminase family
I3J16_RS15360	COG2181	nitrate reductase activity
I3J16_RS15360	COG0247	lactate metabolic process
I3J16_RS15365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J16_RS15370	COG0443	Heat shock 70 kDa protein
I3J16_RS15375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J16_RS15380	COG0484	heat shock protein binding
I3J16_RS15385	COG0789	Transcriptional regulator
I3J16_RS15405	COG0542	response to heat
I3J16_RS15435	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J16_RS15450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J16_RS15455	COG0191	fructose-bisphosphate aldolase activity
I3J16_RS15460	COG0477	Major facilitator Superfamily
I3J16_RS15495	COG4585	Histidine kinase
I3J16_RS15505	COG2124	cytochrome p450
I3J16_RS15535	COG0463	Glycosyl transferase, family 2
I3J16_RS15540	COG1802	Transcriptional regulator
I3J16_RS15555	COG2319	Wd-40 repeat
I3J16_RS15555	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J16_RS15560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS15595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J16_RS15610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J16_RS15615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J16_RS15630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J16_RS15635	COG1595	DNA-templated transcription, initiation
I3J16_RS15660	COG2124	cytochrome p450
I3J16_RS15675	COG2091	lysine biosynthetic process via aminoadipic acid
I3J16_RS15690	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J16_RS15720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J16_RS15805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J16_RS15825	COG1408	metallophosphoesterase
I3J16_RS15830	COG1610	YqeY-like protein
I3J16_RS15835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J16_RS15845	COG0003	Pfam Anion-transporting ATPase
I3J16_RS15875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J16_RS15905	COG2267	carboxylic ester hydrolase activity
I3J16_RS15915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J16_RS15920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J16_RS15925	COG0659	secondary active sulfate transmembrane transporter activity
I3J16_RS15985	COG1111	helicase
I3J16_RS15985	COG1205	dead DEAH box helicase
I3J16_RS15990	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J16_RS15995	COG2172	sigma factor antagonist activity
I3J16_RS16000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J16_RS16010	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J16_RS16020	COG1754	DNA topoisomerase type I activity
I3J16_RS16020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J16_RS16025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J16_RS16030	COG0470	DNA polymerase III
I3J16_RS16040	COG0477	Major facilitator Superfamily
I3J16_RS16080	COG1061	Type III restriction enzyme res subunit
I3J16_RS16125	COG0791	NLP P60 protein
I3J16_RS16205	COG0305	Participates in initiation and elongation during chromosome replication
I3J16_RS16365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J16_RS16475	COG1132	(ABC) transporter
I3J16_RS16480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J16_RS16480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J16_RS16485	COG0110	maltose O-acetyltransferase activity
I3J16_RS16525	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS16530	COG2318	DinB family
I3J16_RS16545	COG0076	glutamate decarboxylase activity
I3J16_RS16560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J16_RS16565	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J16_RS16575	COG0037	tRNA processing
I3J16_RS16590	COG0302	gtp cyclohydrolase
I3J16_RS16605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J16_RS16630	COG1174	glycine betaine transport
I3J16_RS16645	COG0649	NAD binding
I3J16_RS16660	COG2197	response regulator
I3J16_RS16675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J16_RS16680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J16_RS16690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J16_RS16710	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J16_RS16725	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J16_RS16735	COG0739	heme binding
I3J16_RS16740	COG2205	protein histidine kinase activity
I3J16_RS16745	COG0745	RESPONSE REGULATOR receiver
I3J16_RS16755	COG1595	DNA-templated transcription, initiation
I3J16_RS16760	COG1194	a g-specific adenine glycosylase
I3J16_RS16765	COG0671	phosphoesterase, PA-phosphatase related
I3J16_RS16775	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J16_RS16795	COG0248	Ppx GppA phosphatase
I3J16_RS16805	COG0129	dihydroxy-acid dehydratase activity
I3J16_RS16825	COG2226	methyltransferase
I3J16_RS16830	COG1595	DNA-templated transcription, initiation
I3J16_RS16835	COG1252	NADH dehydrogenase
I3J16_RS16840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J16_RS16845	COG0180	Tryptophanyl-tRNA synthetase
I3J16_RS16870	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J16_RS16905	COG1595	DNA-templated transcription, initiation
I3J16_RS16920	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J16_RS16925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J16_RS16930	COG0181	hydroxymethylbilane synthase activity
I3J16_RS16935	COG1648	precorrin-2 dehydrogenase activity
I3J16_RS16935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J16_RS16960	COG1846	Transcriptional regulator
I3J16_RS16965	COG3384	dioxygenase
I3J16_RS16985	COG0477	Major facilitator Superfamily
I3J16_RS16995	COG3191	aminopeptidase activity
I3J16_RS17010	COG1970	mechanosensitive ion channel activity
I3J16_RS17020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J16_RS17045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J16_RS17050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J16_RS17060	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J16_RS17065	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J16_RS17065	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J16_RS17070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J16_RS17115	COG2072	flavoprotein involved in K transport
I3J16_RS17120	COG2267	carboxylic ester hydrolase activity
I3J16_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS17130	COG0793	Belongs to the peptidase S41A family
I3J16_RS17130	COG4946	Tricorn protease homolog
I3J16_RS17140	COG2409	Drug exporters of the RND superfamily
I3J16_RS17150	COG0310	cobalt ion transport
I3J16_RS17160	COG1122	ATPase activity
I3J16_RS17165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J16_RS17205	COG0124	histidyl-tRNA synthetase
I3J16_RS17230	COG3409	Peptidoglycan-binding domain 1 protein
I3J16_RS17235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J16_RS17255	COG0442	prolyl-tRNA aminoacylation
I3J16_RS17285	COG0084	hydrolase, TatD family'
I3J16_RS17295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J16_RS17300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J16_RS17325	COG0488	(ABC) transporter
I3J16_RS17355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J16_RS17360	COG2197	response regulator
I3J16_RS17370	COG4106	trans-aconitate 2-methyltransferase activity
I3J16_RS17375	COG1309	transcriptional regulator
I3J16_RS17385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J16_RS17395	COG0193	aminoacyl-tRNA hydrolase activity
I3J16_RS17400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J16_RS17405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J16_RS17410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J16_RS17420	COG4585	Histidine kinase
I3J16_RS17450	COG0477	Major facilitator Superfamily
I3J16_RS17465	COG1136	(ABC) transporter
I3J16_RS17470	COG0577	efflux transmembrane transporter activity
I3J16_RS17480	COG1595	DNA-templated transcription, initiation
I3J16_RS17505	COG0515	serine threonine protein kinase
I3J16_RS17505	COG2815	serine threonine protein kinase
I3J16_RS17535	COG1652	LysM domain
I3J16_RS17545	COG0148	phosphopyruvate hydratase activity
I3J16_RS17565	COG1252	NADH dehydrogenase
I3J16_RS17570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J16_RS17575	COG0577	efflux transmembrane transporter activity
I3J16_RS17575	COG1136	(ABC) transporter
I3J16_RS17580	COG1136	(ABC) transporter
I3J16_RS17580	COG0577	efflux transmembrane transporter activity
I3J16_RS17610	COG0183	Belongs to the thiolase family
I3J16_RS17615	COG2755	lipolytic protein G-D-S-L family
I3J16_RS17630	COG1737	Transcriptional regulator
I3J16_RS17690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J16_RS17720	COG1228	amidohydrolase
I3J16_RS17745	COG1191	sigma factor activity
I3J16_RS17770	COG3104	oligopeptide transport
I3J16_RS17775	COG0745	RESPONSE REGULATOR receiver
I3J16_RS17780	COG2205	protein histidine kinase activity
I3J16_RS17815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J16_RS17900	COG1309	transcriptional regulator
I3J16_RS17905	COG0596	Alpha beta hydrolase
I3J16_RS17910	COG1316	TRANSCRIPTIONal
I3J16_RS17915	COG1607	acyl-coa hydrolase
I3J16_RS17920	COG1316	TRANSCRIPTIONal
I3J16_RS17940	COG1316	TRANSCRIPTIONal
I3J16_RS17965	COG0778	Nitroreductase
I3J16_RS17965	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J16_RS17970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J16_RS18005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J16_RS18010	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J16_RS18020	COG1482	cell wall glycoprotein biosynthetic process
I3J16_RS18030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J16_RS18055	COG2826	transposase and inactivated derivatives, IS30 family
I3J16_RS18065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J16_RS18070	COG0745	RESPONSE REGULATOR receiver
I3J16_RS18075	COG5002	protein histidine kinase activity
I3J16_RS18075	COG5000	phosphorelay sensor kinase activity
I3J16_RS18080	COG0823	Involved in the tonB-independent uptake of proteins
I3J16_RS18090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J16_RS18095	COG2197	response regulator
I3J16_RS18100	COG3214	Protein conserved in bacteria
I3J16_RS18110	COG0653	protein targeting
I3J16_RS18135	COG2902	Dehydrogenase
I3J16_RS18145	COG0395	ABC-type sugar transport system, permease component
I3J16_RS18150	COG1175	transmembrane transport
I3J16_RS18165	COG0515	serine threonine protein kinase
I3J16_RS18170	COG0515	serine threonine protein kinase
I3J16_RS18175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J16_RS18185	COG2884	Cell division ATP-binding protein ftsE
I3J16_RS18195	COG0793	Belongs to the peptidase S41A family
I3J16_RS18200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J16_RS18215	COG0583	DNA-binding transcription factor activity
I3J16_RS18240	COG3973	AAA domain
I3J16_RS18250	COG0776	regulation of translation
I3J16_RS18255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J16_RS18260	COG1678	Uncharacterized ACR, COG1678
I3J16_RS18275	COG1175	transmembrane transport
I3J16_RS18280	COG0395	ABC-type sugar transport system, permease component
I3J16_RS18285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J16_RS18325	COG3654	unkown
I3J16_RS18350	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J16_RS18355	COG0745	RESPONSE REGULATOR receiver
I3J16_RS18360	COG5002	protein histidine kinase activity
I3J16_RS18380	COG0277	FAD linked oxidase domain protein
I3J16_RS18420	COG1335	isochorismatase
I3J16_RS18430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J16_RS18440	COG1113	amino acid transport
I3J16_RS18450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J16_RS18455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS18460	COG1120	ATPase activity
I3J16_RS18475	COG1234	tRNA 3'-trailer cleavage
I3J16_RS18480	COG1263	PTS System
I3J16_RS18485	COG1263	PTS System
I3J16_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J16_RS18495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J16_RS18505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J16_RS18535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J16_RS18545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J16_RS18560	COG1131	(ABC) transporter
I3J16_RS18570	COG2733	membrane
I3J16_RS18600	COG0706	membrane insertase activity
I3J16_RS18610	COG0673	inositol 2-dehydrogenase activity
I3J16_RS18680	COG1126	abc transporter atp-binding protein
I3J16_RS18685	COG0765	amino acid transport
I3J16_RS18690	COG0765	amino acid transport
I3J16_RS18700	COG0154	amidase activity
I3J16_RS18710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS18745	COG0406	alpha-ribazole phosphatase activity
I3J16_RS18785	COG0745	RESPONSE REGULATOR receiver
I3J16_RS18800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J16_RS18805	COG4977	sequence-specific DNA binding
I3J16_RS18815	COG0589	response to stress
I3J16_RS18820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J16_RS18845	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J16_RS18850	COG0076	glutamate decarboxylase activity
I3J16_RS18860	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS18875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J16_RS18880	COG1309	transcriptional regulator
I3J16_RS18890	COG2124	cytochrome p450
I3J16_RS18895	COG1946	Acyl-CoA thioesterase
I3J16_RS18910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J16_RS18920	COG3960	tartronate-semialdehyde synthase activity
I3J16_RS18940	COG1674	ftsk spoiiie
I3J16_RS19005	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J16_RS19020	COG1609	Transcriptional regulator
I3J16_RS19025	COG0673	inositol 2-dehydrogenase activity
I3J16_RS19040	COG1595	DNA-templated transcription, initiation
I3J16_RS19050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J16_RS19075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J16_RS19085	COG3718	enzyme involved in inositol metabolism
I3J16_RS19090	COG3962	Belongs to the TPP enzyme family
I3J16_RS19110	COG1131	(ABC) transporter
I3J16_RS19170	COG0105	UTP biosynthetic process
I3J16_RS19175	COG2197	response regulator
I3J16_RS19185	COG2954	triphosphatase activity
I3J16_RS19195	COG0494	nUDIX hydrolase
I3J16_RS19225	COG0561	phosphatase activity
I3J16_RS19235	COG0475	glutathione-regulated potassium exporter activity
I3J16_RS19265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J16_RS19275	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J16_RS19280	COG1518	maintenance of DNA repeat elements
I3J16_RS19290	COG1203	CRISPR-associated helicase, Cas3
I3J16_RS19330	COG0629	single-stranded DNA binding
I3J16_RS19360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J16_RS19405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J16_RS19420	COG1486	melibiose metabolic process
I3J16_RS19425	COG0395	ABC-type sugar transport system, permease component
I3J16_RS19430	COG1175	transmembrane transport
I3J16_RS19450	COG0668	transmembrane transport
I3J16_RS19520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J16_RS19525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J16_RS19535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J16_RS19545	COG0588	phosphoglycerate mutase activity
I3J16_RS19550	COG1113	amino acid transport
I3J16_RS19560	COG1113	amino acid transport
I3J16_RS19575	COG4552	Acetyltransferase involved in intracellular survival and related
I3J16_RS19590	COG0475	glutathione-regulated potassium exporter activity
I3J16_RS19605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J16_RS19610	COG3594	Acyltransferase
I3J16_RS19630	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J16_RS19635	COG0740	serine-type endopeptidase activity
I3J16_RS19640	COG0740	serine-type endopeptidase activity
I3J16_RS19645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J16_RS19655	COG0525	valine-tRNA ligase activity
I3J16_RS19660	COG4585	Histidine kinase
I3J16_RS19665	COG0285	dihydrofolate synthase activity
I3J16_RS19675	COG0105	UTP biosynthetic process
I3J16_RS19680	COG1077	Cell shape determining protein MreB Mrl
I3J16_RS19700	COG0772	Belongs to the SEDS family
I3J16_RS19720	COG1530	ribonuclease E activity
I3J16_RS19730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J16_RS19735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J16_RS19740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J16_RS19745	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS19760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J16_RS19770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J16_RS19785	COG0501	Belongs to the peptidase M48B family
I3J16_RS19795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J16_RS19805	COG0799	negative regulation of ribosome biogenesis
I3J16_RS19810	COG0588	phosphoglycerate mutase activity
I3J16_RS19820	COG0495	leucyl-tRNA aminoacylation
I3J16_RS19830	COG1307	EDD domain protein, DegV family
I3J16_RS19865	COG0268	Binds directly to 16S ribosomal RNA
I3J16_RS19870	COG0481	GTPase activity
I3J16_RS19895	COG1420	regulation of RNA biosynthetic process
I3J16_RS19900	COG0484	heat shock protein binding
I3J16_RS19920	COG4946	Tricorn protease homolog
I3J16_RS19920	COG0793	Belongs to the peptidase S41A family
I3J16_RS19925	COG0537	adenosine 5'-monophosphoramidase activity
I3J16_RS19930	COG1234	tRNA 3'-trailer cleavage
I3J16_RS19935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J16_RS19940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J16_RS19950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J16_RS19990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J16_RS20005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J16_RS20020	COG1381	Involved in DNA repair and RecF pathway recombination
I3J16_RS20025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J16_RS20035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J16_RS20040	COG3842	ATPase activity
I3J16_RS20045	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J16_RS20045	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J16_RS20050	COG0423	glycine-tRNA ligase activity
I3J16_RS20090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J16_RS20090	COG0574	Belongs to the PEP-utilizing enzyme family
I3J16_RS20105	COG0531	amino acid
I3J16_RS20115	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS20120	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J16_RS20140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J16_RS20160	COG2949	membrane
I3J16_RS20165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J16_RS20175	COG0358	DNA primase activity
I3J16_RS20180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J16_RS20195	COG1070	Carbohydrate kinase
I3J16_RS20230	COG1129	ABC transporter
I3J16_RS20230	COG0842	Transport permease protein
I3J16_RS20290	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS20300	COG1136	(ABC) transporter
I3J16_RS20355	COG2130	NADP-dependent
I3J16_RS20390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J16_RS20395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J16_RS20400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J16_RS20425	COG0789	Transcriptional regulator
I3J16_RS20430	COG0667	Aldo Keto reductase
I3J16_RS20435	COG2197	response regulator
I3J16_RS20440	COG4585	Histidine kinase
I3J16_RS20460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J16_RS20465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J16_RS20510	COG1358	cellular component organization or biogenesis
I3J16_RS20520	COG0586	Pfam SNARE associated Golgi protein
I3J16_RS20545	COG0582	viral genome integration into host DNA
I3J16_RS20655	COG4122	O-methyltransferase activity
I3J16_RS20665	COG2124	cytochrome p450
I3J16_RS20670	COG0183	Belongs to the thiolase family
I3J16_RS20685	COG3845	ABC transporter
I3J16_RS20720	COG1309	transcriptional regulator
I3J16_RS20725	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS20730	COG2226	methyltransferase
I3J16_RS20740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS20760	COG0183	Belongs to the thiolase family
I3J16_RS20775	COG2030	dehydratase
I3J16_RS20780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J16_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS20800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J16_RS20820	COG0800	Aldolase
I3J16_RS20825	COG3022	response to hydroperoxide
I3J16_RS20840	COG0789	Transcriptional regulator
I3J16_RS20860	COG1349	DNA-binding transcription factor activity
I3J16_RS20865	COG1653	transport
I3J16_RS20875	COG0395	ABC-type sugar transport system, permease component
I3J16_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS20925	COG3540	Alkaline phosphatase
I3J16_RS20930	COG2814	Major facilitator Superfamily
I3J16_RS20945	COG1834	amidinotransferase
I3J16_RS20965	COG1120	ATPase activity
I3J16_RS20970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS20995	COG5398	heme oxygenase
I3J16_RS21030	COG1994	Peptidase M50
I3J16_RS21050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J16_RS21060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J16_RS21060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J16_RS21065	COG2132	Multicopper oxidase
I3J16_RS21100	COG0174	glutamine synthetase
I3J16_RS21115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J16_RS21130	COG1228	amidohydrolase
I3J16_RS21155	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J16_RS21160	COG0494	nUDIX hydrolase
I3J16_RS21175	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J16_RS21195	COG1609	Transcriptional regulator
I3J16_RS21200	COG0366	Alpha amylase catalytic
I3J16_RS21205	COG3833	ABC-type maltose transport systems, permease component
I3J16_RS21210	COG1175	transmembrane transport
I3J16_RS21240	COG2197	response regulator
I3J16_RS21280	COG0745	RESPONSE REGULATOR receiver
I3J16_RS21290	COG0673	inositol 2-dehydrogenase activity
I3J16_RS21315	COG0181	hydroxymethylbilane synthase activity
I3J16_RS21365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J16_RS21370	COG0321	lipoyl(octanoyl) transferase activity
I3J16_RS21385	COG1090	epimerase
I3J16_RS21415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J16_RS21425	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J16_RS21430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J16_RS21435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J16_RS21440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J16_RS21450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J16_RS21480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J16_RS21485	COG1132	(ABC) transporter
I3J16_RS21510	COG4585	Histidine kinase
I3J16_RS21515	COG2197	response regulator
I3J16_RS21520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J16_RS21530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J16_RS21550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J16_RS21560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J16_RS21565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J16_RS21575	COG1376	ErfK ybiS ycfS ynhG family protein
I3J16_RS21585	COG1845	cytochrome c oxidase, subunit III
I3J16_RS21590	COG2010	Cytochrome c
I3J16_RS21595	COG0723	plastoquinol--plastocyanin reductase activity
I3J16_RS21600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J16_RS21605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J16_RS21610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J16_RS21615	COG1929	Belongs to the glycerate kinase type-1 family
I3J16_RS21625	COG0745	RESPONSE REGULATOR receiver
I3J16_RS21630	COG2205	protein histidine kinase activity
I3J16_RS21680	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS21705	COG0003	Pfam Anion-transporting ATPase
I3J16_RS21715	COG1940	carbohydrate kinase activity
I3J16_RS21745	COG2197	response regulator
I3J16_RS21750	COG0205	6-phosphofructokinase activity
I3J16_RS21760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J16_RS21765	COG0243	molybdopterin cofactor binding
I3J16_RS21770	COG2193	ferroxidase activity
I3J16_RS21775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J16_RS21780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J16_RS21785	COG2815	serine threonine protein kinase
I3J16_RS21785	COG0515	serine threonine protein kinase
I3J16_RS21790	COG2022	thiamine diphosphate biosynthetic process
I3J16_RS21800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J16_RS21800	COG2022	thiamine diphosphate biosynthetic process
I3J16_RS21820	COG0352	thiamine-phosphate diphosphorylase activity
I3J16_RS21835	COG1233	COG1233 Phytoene dehydrogenase and related
I3J16_RS21845	COG1309	transcriptional regulator
I3J16_RS21850	COG1511	domain protein
I3J16_RS21855	COG1121	(ABC) transporter
I3J16_RS21885	COG0714	Associated with various cellular activities
I3J16_RS21895	COG0275	rRNA processing
I3J16_RS21905	COG0768	penicillin binding
I3J16_RS21910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J16_RS21915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J16_RS21920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J16_RS21925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J16_RS21935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J16_RS21940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J16_RS21950	COG1496	oxidoreductase activity
I3J16_RS21960	COG1799	cell septum assembly
I3J16_RS21970	COG3599	regulation of cell shape
I3J16_RS21975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J16_RS21990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J16_RS22040	COG0587	DNA-directed DNA polymerase activity
I3J16_RS22050	COG1432	Conserved Protein
I3J16_RS22070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J16_RS22090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J16_RS22095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J16_RS22100	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J16_RS22110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J16_RS22115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J16_RS22120	COG0251	oxidation-reduction process
I3J16_RS22125	COG0107	imidazoleglycerol-phosphate synthase activity
I3J16_RS22140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J16_RS22145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J16_RS22165	COG0134	indole-3-glycerol-phosphate synthase activity
I3J16_RS22175	COG0133	tryptophan synthase activity
I3J16_RS22180	COG0159	tryptophan synthase activity
I3J16_RS22190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J16_RS22195	COG2301	Belongs to the HpcH HpaI aldolase family
I3J16_RS22200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J16_RS22205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J16_RS22240	COG0069	glutamate synthase activity
I3J16_RS22240	COG0067	glutamate synthase
I3J16_RS22240	COG0070	glutamate synthase
I3J16_RS22265	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS22275	COG1309	transcriptional regulator
I3J16_RS22280	COG0183	Belongs to the thiolase family
I3J16_RS22310	COG1024	Enoyl-CoA hydratase
I3J16_RS22320	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS22335	COG1470	cell adhesion involved in biofilm formation
I3J16_RS22335	COG0366	Alpha amylase catalytic
I3J16_RS22350	COG1605	Chorismate mutase
I3J16_RS22350	COG0287	Prephenate dehydrogenase
I3J16_RS22400	COG0411	ABC transporter
I3J16_RS22420	COG2050	protein possibly involved in aromatic compounds catabolism
I3J16_RS22450	COG1643	Atp-dependent helicase
I3J16_RS22455	COG2226	methyltransferase
I3J16_RS22455	COG0596	Alpha beta hydrolase
I3J16_RS22455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J16_RS22460	COG0539	negative regulation of cytoplasmic translation
I3J16_RS22470	COG0237	dephospho-CoA kinase activity
I3J16_RS22490	COG0330	HflC and HflK could
I3J16_RS22495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J16_RS22525	COG2313	pseudouridylate synthase activity
I3J16_RS22535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J16_RS22540	COG0584	glycerophosphoryl diester phosphodiesterase
I3J16_RS22550	COG0556	nucleotide-excision repair
I3J16_RS22570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J16_RS22580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J16_RS22585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J16_RS22585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J16_RS22610	COG0322	excinuclease ABC activity
I3J16_RS22615	COG1660	Displays ATPase and GTPase activities
I3J16_RS22620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J16_RS22625	COG1481	regulation of sporulation
I3J16_RS22635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J16_RS22640	COG0126	phosphoglycerate kinase activity
I3J16_RS22645	COG0149	triose-phosphate isomerase activity
I3J16_RS22650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J16_RS22660	COG0166	Belongs to the GPI family
I3J16_RS22665	COG3402	PFAM membrane-flanked domain
I3J16_RS22675	COG0363	glucosamine-6-phosphate deaminase activity
I3J16_RS22690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J16_RS22700	COG0109	protoheme IX farnesyltransferase activity
I3J16_RS22730	COG1131	(ABC) transporter
I3J16_RS22745	COG0719	Fe-S assembly protein
I3J16_RS22755	COG0396	ATPase activity
I3J16_RS22760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J16_RS22765	COG0822	iron-sulfur transferase activity
I3J16_RS22770	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J16_RS22775	COG2171	N-acyltransferase activity
I3J16_RS22785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J16_RS22835	COG2205	protein histidine kinase activity
I3J16_RS22840	COG0745	RESPONSE REGULATOR receiver
I3J16_RS22855	COG1802	Transcriptional regulator
I3J16_RS22870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J16_RS22875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J16_RS22885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J16_RS22895	COG0768	penicillin binding
I3J16_RS22900	COG2197	response regulator
I3J16_RS22905	COG4585	Histidine kinase
I3J16_RS22910	COG1414	Transcriptional regulator
I3J16_RS22935	COG1902	pentaerythritol trinitrate reductase activity
I3J16_RS22940	COG5285	phytanoyl-CoA dioxygenase
I3J16_RS22945	COG1917	Cupin 2, conserved barrel domain protein
I3J16_RS22960	COG0134	indole-3-glycerol-phosphate synthase activity
I3J16_RS22990	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J16_RS23005	COG1492	cobalamin metabolic process
I3J16_RS23010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J16_RS23025	COG0235	Class ii aldolase
I3J16_RS23040	COG0488	(ABC) transporter
I3J16_RS23050	COG1024	Enoyl-CoA hydratase
I3J16_RS23090	COG3387	PFAM Glycoside hydrolase 15-related
I3J16_RS23125	COG1404	Belongs to the peptidase S8 family
I3J16_RS23135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J16_RS23140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J16_RS23160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J16_RS23175	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS23180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J16_RS23185	COG2186	Transcriptional regulator
I3J16_RS23190	COG2807	transmembrane transport
I3J16_RS23205	COG3830	Belongs to the UPF0237 family
I3J16_RS23205	COG0560	Phosphoserine phosphatase
I3J16_RS23210	COG1131	(ABC) transporter
I3J16_RS23210	COG1716	ATPase activity
I3J16_RS23210	COG0842	Transport permease protein
I3J16_RS23220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J16_RS23230	COG4585	Histidine kinase
I3J16_RS23235	COG2197	response regulator
I3J16_RS23250	COG1119	ATPase activity
I3J16_RS23275	COG1881	PFAM PEBP family protein
I3J16_RS23285	COG2094	Belongs to the DNA glycosylase MPG family
I3J16_RS23320	COG0647	UMP catabolic process
I3J16_RS23325	COG1120	ATPase activity
I3J16_RS23345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J16_RS23350	COG0497	DNA recombination
I3J16_RS23355	COG0297	glycogen (starch) synthase activity
I3J16_RS23365	COG3387	PFAM Glycoside hydrolase 15-related
I3J16_RS23370	COG0504	CTP synthase activity
I3J16_RS23375	COG0494	nUDIX hydrolase
I3J16_RS23385	COG0686	Belongs to the AlaDH PNT family
I3J16_RS23400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J16_RS23405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J16_RS23410	COG1187	pseudouridine synthase activity
I3J16_RS23415	COG1056	cytidyltransferase-related domain
I3J16_RS23415	COG1051	belongs to the nudix hydrolase family
I3J16_RS23440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J16_RS23450	COG1160	GTP binding
I3J16_RS23470	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS23480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J16_RS23490	COG0671	phosphoesterase, PA-phosphatase related
I3J16_RS23495	COG0477	Major facilitator Superfamily
I3J16_RS23500	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS23505	COG1799	cell septum assembly
I3J16_RS23555	COG0641	radical SAM
I3J16_RS23570	COG3629	intracellular signal transduction
I3J16_RS23570	COG3903	Transcriptional regulator
I3J16_RS23575	COG0596	Alpha beta hydrolase
I3J16_RS23600	COG4565	transcriptional regulatory protein
I3J16_RS23625	COG1725	Transcriptional regulator
I3J16_RS23635	COG2755	lipolytic protein G-D-S-L family
I3J16_RS23645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J16_RS23650	COG2188	Transcriptional regulator
I3J16_RS23655	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J16_RS23660	COG2851	Citrate transporter
I3J16_RS23695	COG3876	Protein conserved in bacteria
I3J16_RS23710	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS23725	COG2149	membrane
I3J16_RS23745	COG3265	gluconokinase activity
I3J16_RS23750	COG2186	Transcriptional regulator
I3J16_RS23755	COG1113	amino acid transport
I3J16_RS23785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J16_RS23815	COG0667	Aldo Keto reductase
I3J16_RS23820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS23830	COG0598	Magnesium transport protein CorA
I3J16_RS23850	COG0215	cysteine-tRNA ligase activity
I3J16_RS23860	COG4948	Mandelate Racemase Muconate Lactonizing
I3J16_RS23865	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS23875	COG1129	ABC transporter
I3J16_RS23885	COG2186	Transcriptional regulator
I3J16_RS23890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J16_RS23895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J16_RS23900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J16_RS23905	COG1414	Transcriptional regulator
I3J16_RS23910	COG1410	methionine synthase
I3J16_RS23910	COG0646	methionine synthase
I3J16_RS23915	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS23930	COG2197	response regulator
I3J16_RS23940	COG1994	Peptidase M50
I3J16_RS23940	COG0517	IMP dehydrogenase activity
I3J16_RS23960	COG1222	aaa ATPase
I3J16_RS23965	COG4122	O-methyltransferase activity
I3J16_RS23980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J16_RS23985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J16_RS23990	COG1609	Transcriptional regulator
I3J16_RS24000	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J16_RS24035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J16_RS24040	COG0805	protein transport
I3J16_RS24075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J16_RS24080	COG0517	IMP dehydrogenase activity
I3J16_RS24080	COG4175	Glycine betaine
I3J16_RS24100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J16_RS24105	COG1113	amino acid transport
I3J16_RS24110	COG2186	Transcriptional regulator
I3J16_RS24115	COG0174	glutamine synthetase
I3J16_RS24140	COG1404	Belongs to the peptidase S8 family
I3J16_RS24160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J16_RS24165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J16_RS24170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J16_RS24175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J16_RS24180	COG5002	protein histidine kinase activity
I3J16_RS24185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J16_RS24190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J16_RS24190	COG0072	phenylalanine-tRNA ligase activity
I3J16_RS24210	COG1649	PFAM Uncharacterised BCR, COG1649
I3J16_RS24220	COG0697	spore germination
I3J16_RS24230	COG2838	Isocitrate dehydrogenase
I3J16_RS24255	COG4585	Histidine kinase
I3J16_RS24260	COG2197	response regulator
I3J16_RS24265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J16_RS24270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J16_RS24275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J16_RS24280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J16_RS24285	COG1438	arginine binding
I3J16_RS24290	COG0137	argininosuccinate synthase activity
I3J16_RS24295	COG0165	Argininosuccinate lyase
I3J16_RS24305	COG0477	Major facilitator Superfamily
I3J16_RS24310	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS24310	COG0204	Acyl-transferase
I3J16_RS24315	COG0584	glycerophosphoryl diester phosphodiesterase
I3J16_RS24335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J16_RS24340	COG2011	ABC-type metal ion transport system permease component
I3J16_RS24345	COG1464	Belongs to the NlpA lipoprotein family
I3J16_RS24360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J16_RS24365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J16_RS24365	COG1648	precorrin-2 dehydrogenase activity
I3J16_RS24410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J16_RS24420	COG0456	acetyltransferase
I3J16_RS24470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J16_RS24475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J16_RS24480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J16_RS24500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J16_RS24505	COG1560	Kdo2-lipid A biosynthetic process
I3J16_RS24510	COG0438	transferase activity, transferring glycosyl groups
I3J16_RS24520	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J16_RS24525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J16_RS24530	COG0217	transcriptional regulatory protein
I3J16_RS24535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J16_RS24540	COG0632	four-way junction helicase activity
I3J16_RS24545	COG2255	four-way junction helicase activity
I3J16_RS24555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J16_RS24560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J16_RS24565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J16_RS24570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J16_RS24580	COG1196	nuclear chromosome segregation
I3J16_RS24585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J16_RS24595	COG0124	histidyl-tRNA synthetase
I3J16_RS24615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J16_RS24630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J16_RS24635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J16_RS24640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J16_RS24645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J16_RS24650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J16_RS24655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J16_RS24660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J16_RS24665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J16_RS24675	COG0006	proline dipeptidase activity
I3J16_RS24680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J16_RS24685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J16_RS24695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J16_RS24700	COG0540	Belongs to the ATCase OTCase family
I3J16_RS24705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J16_RS24715	COG0505	Belongs to the CarA family
I3J16_RS24720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J16_RS24725	COG0167	dihydroorotate dehydrogenase activity
I3J16_RS24730	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J16_RS24755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J16_RS24770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J16_RS24780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J16_RS24785	COG2390	Transcriptional regulator
I3J16_RS24815	COG1191	sigma factor activity
I3J16_RS24825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J16_RS24840	COG2233	PERMEase
I3J16_RS24850	COG0738	Major facilitator superfamily
I3J16_RS24855	COG1940	carbohydrate kinase activity
I3J16_RS24855	COG1846	Transcriptional regulator
I3J16_RS24870	COG3201	nicotinamide mononucleotide transporter
I3J16_RS24875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J16_RS24875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J16_RS24880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J16_RS24885	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J16_RS24890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J16_RS24930	COG1309	transcriptional regulator
I3J16_RS24935	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS24955	COG1216	Glycosyl transferase, family 2
I3J16_RS24970	COG2270	Major facilitator Superfamily
I3J16_RS24980	COG2364	Membrane
I3J16_RS24985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J16_RS25015	COG1984	allophanate hydrolase subunit 2
I3J16_RS25020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J16_RS25025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J16_RS25030	COG2814	Major facilitator Superfamily
I3J16_RS25060	COG5002	protein histidine kinase activity
I3J16_RS25065	COG2018	Roadblock/LC7 domain
I3J16_RS25080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J16_RS25085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J16_RS25090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J16_RS25110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J16_RS25120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J16_RS25150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J16_RS25170	COG1716	ATPase activity
I3J16_RS25190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J16_RS25200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J16_RS25200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J16_RS25265	COG0697	spore germination
I3J16_RS25320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J16_RS25335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J16_RS25345	COG2813	Specifically methylates the guanine in position
I3J16_RS25360	COG1968	undecaprenyl-diphosphatase activity
I3J16_RS25375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J16_RS25400	COG2124	cytochrome p450
I3J16_RS25430	COG0110	maltose O-acetyltransferase activity
I3J16_RS25435	COG1832	CoA-binding protein
I3J16_RS25440	COG1739	Uncharacterized protein family UPF0029
I3J16_RS25450	COG0666	response to abiotic stimulus
I3J16_RS25455	COG0420	3'-5' exonuclease activity
I3J16_RS25460	COG0419	ATPase involved in DNA repair
I3J16_RS25460	COG0419	ATPase involved in DNA repair
I3J16_RS25465	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS25495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J16_RS25510	COG2188	Transcriptional regulator
I3J16_RS25515	COG1940	carbohydrate kinase activity
I3J16_RS25525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J16_RS25560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J16_RS25565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS25570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J16_RS25590	COG0740	serine-type endopeptidase activity
I3J16_RS25600	COG0831	urea catabolic process
I3J16_RS25605	COG0832	Belongs to the urease beta subunit family
I3J16_RS25610	COG0804	urea catabolic process
I3J16_RS25620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J16_RS25625	COG0829	nickel cation binding
I3J16_RS25635	COG0204	Acyl-transferase
I3J16_RS25650	COG0142	geranyltranstransferase activity
I3J16_RS25655	COG0142	geranyltranstransferase activity
I3J16_RS25675	COG0205	6-phosphofructokinase activity
I3J16_RS25680	COG3442	glutamine amidotransferase
I3J16_RS25690	COG0242	peptide deformylase activity
I3J16_RS25700	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS25725	COG0386	Belongs to the glutathione peroxidase family
I3J16_RS25730	COG1946	Acyl-CoA thioesterase
I3J16_RS25750	COG1132	(ABC) transporter
I3J16_RS25750	COG2375	cellular response to nickel ion
I3J16_RS25755	COG1132	(ABC) transporter
I3J16_RS25765	COG2409	Drug exporters of the RND superfamily
I3J16_RS25780	COG2124	cytochrome p450
I3J16_RS25790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J16_RS25800	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS25815	COG0477	Major facilitator Superfamily
I3J16_RS25845	COG4585	Histidine kinase
I3J16_RS25850	COG2197	response regulator
I3J16_RS25870	COG2409	Drug exporters of the RND superfamily
I3J16_RS25880	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J16_RS25880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J16_RS25885	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J16_RS25940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J16_RS25945	COG0604	alcohol dehydrogenase
I3J16_RS25945	COG3321	synthase
I3J16_RS25960	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS25980	COG1132	(ABC) transporter
I3J16_RS25985	COG2072	flavoprotein involved in K transport
I3J16_RS26045	COG0443	Heat shock 70 kDa protein
I3J16_RS26060	COG1309	transcriptional regulator
I3J16_RS26070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS26075	COG1902	pentaerythritol trinitrate reductase activity
I3J16_RS26130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J16_RS26175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS26180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS26185	COG1120	ATPase activity
I3J16_RS26195	COG1132	(ABC) transporter
I3J16_RS26220	COG4607	ABC-type enterochelin transport system periplasmic component
I3J16_RS26225	COG0464	growth
I3J16_RS26230	COG1404	Belongs to the peptidase S8 family
I3J16_RS26235	COG1674	ftsk spoiiie
I3J16_RS26300	COG1278	Cold shock
I3J16_RS26315	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J16_RS26325	COG0577	efflux transmembrane transporter activity
I3J16_RS26325	COG1136	(ABC) transporter
I3J16_RS26330	COG0577	efflux transmembrane transporter activity
I3J16_RS26330	COG1136	(ABC) transporter
I3J16_RS26345	COG0745	RESPONSE REGULATOR receiver
I3J16_RS26350	COG2205	protein histidine kinase activity
I3J16_RS26385	COG0463	Glycosyl transferase, family 2
I3J16_RS26390	COG0326	Molecular chaperone. Has ATPase activity
I3J16_RS26430	COG0309	Hydrogenase expression formation protein (HypE)
I3J16_RS26440	COG0298	carbon dioxide binding
I3J16_RS26450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J16_RS26455	COG0375	protein maturation
I3J16_RS26535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J16_RS26570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J16_RS26585	COG2706	6-phosphogluconolactonase activity
I3J16_RS26600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J16_RS26625	COG1309	transcriptional regulator
I3J16_RS26630	COG0671	phosphoesterase, PA-phosphatase related
I3J16_RS26655	COG0584	glycerophosphoryl diester phosphodiesterase
I3J16_RS26675	COG0204	Acyl-transferase
I3J16_RS26685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J16_RS26705	COG3345	alpha-galactosidase
I3J16_RS26715	COG1175	transmembrane transport
I3J16_RS26720	COG0395	ABC-type sugar transport system, permease component
I3J16_RS26740	COG0644	oxidoreductase
I3J16_RS26755	COG1940	carbohydrate kinase activity
I3J16_RS26775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J16_RS26785	COG1349	DNA-binding transcription factor activity
I3J16_RS26805	COG1215	transferase activity, transferring glycosyl groups
I3J16_RS26810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J16_RS26895	COG1486	melibiose metabolic process
I3J16_RS26940	COG1012	belongs to the aldehyde dehydrogenase family
I3J16_RS26945	COG0363	glucosamine-6-phosphate deaminase activity
I3J16_RS26970	COG1461	Dihydroxyacetone kinase
I3J16_RS26975	COG2376	Dihydroxyacetone kinase
I3J16_RS27010	COG1131	(ABC) transporter
I3J16_RS27065	COG1846	Transcriptional regulator
I3J16_RS27100	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J16_RS27105	COG1959	2 iron, 2 sulfur cluster binding
I3J16_RS27110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J16_RS27110	COG1017	nitric oxide dioxygenase activity
I3J16_RS27130	COG3511	phospholipase C
I3J16_RS27140	COG1796	DNA polymerase
I3J16_RS27140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J16_RS27150	COG2814	Major facilitator Superfamily
I3J16_RS27190	COG1960	acyl-CoA dehydrogenase activity
I3J16_RS27200	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J16_RS27215	COG1335	isochorismatase
I3J16_RS27220	COG0010	Belongs to the arginase family
I3J16_RS27225	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J16_RS27270	COG0701	Predicted permease
I3J16_RS27280	COG2815	serine threonine protein kinase
I3J16_RS27280	COG0515	serine threonine protein kinase
I3J16_RS27290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J16_RS27295	COG2070	2-Nitropropane dioxygenase
I3J16_RS27305	COG0387	Pfam Sodium calcium exchanger
I3J16_RS27310	COG2267	carboxylic ester hydrolase activity
I3J16_RS27315	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS27380	COG2375	cellular response to nickel ion
I3J16_RS27380	COG1132	(ABC) transporter
I3J16_RS27395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J16_RS27395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J16_RS27405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J16_RS27410	COG0765	amino acid transport
I3J16_RS27415	COG1126	abc transporter atp-binding protein
I3J16_RS27435	COG1957	nucleoside hydrolase
I3J16_RS27445	COG2318	DinB family
I3J16_RS27465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS27470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J16_RS27515	COG0501	Belongs to the peptidase M48B family
I3J16_RS27555	COG4412	M6 family metalloprotease domain protein
I3J16_RS27555	COG1404	Belongs to the peptidase S8 family
I3J16_RS27555	COG1404	Belongs to the peptidase S8 family
I3J16_RS27555	COG4412	M6 family metalloprotease domain protein
I3J16_RS27610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J16_RS27625	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS27660	COG0288	reversible hydration of carbon dioxide
I3J16_RS27670	COG0702	epimerase
I3J16_RS27680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J16_RS27695	COG2226	methyltransferase
I3J16_RS27705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J16_RS27710	COG1937	Protein conserved in bacteria
I3J16_RS27740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J16_RS27805	COG0142	geranyltranstransferase activity
I3J16_RS27815	COG1132	(ABC) transporter
I3J16_RS27825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J16_RS28020	COG3321	synthase
I3J16_RS28020	COG0604	alcohol dehydrogenase
I3J16_RS28030	COG3321	synthase
I3J16_RS28030	COG0604	alcohol dehydrogenase
I3J16_RS28035	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J16_RS28215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J16_RS28260	COG2161	toxin-antitoxin pair type II binding
I3J16_RS28305	COG3547	Transposase (IS116 IS110 IS902 family)
I3J16_RS28315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J16_RS28320	COG0318	PFAM AMP-dependent synthetase and ligase
I3J16_RS28390	COG2197	response regulator
I3J16_RS28420	COG2814	Major facilitator Superfamily
I3J16_RS28425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J16_RS28440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J16_RS28480	COG3321	synthase
I3J16_RS28480	COG0604	alcohol dehydrogenase
I3J16_RS28500	COG2814	Major facilitator Superfamily
I3J16_RS28520	COG0076	glutamate decarboxylase activity
I3J16_RS28555	COG0531	amino acid
I3J16_RS28565	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J16_RS28580	COG2304	oxidoreductase activity
I3J16_RS28620	COG2197	response regulator
I3J16_RS28630	COG1222	aaa ATPase
I3J16_RS28640	COG3629	intracellular signal transduction
I3J16_RS28640	COG3903	Transcriptional regulator
I3J16_RS28715	COG2124	cytochrome p450
I3J16_RS28745	COG0789	Transcriptional regulator
I3J16_RS28750	COG0436	Aminotransferase
I3J16_RS28760	COG1695	Transcriptional regulator
I3J16_RS28765	COG2124	cytochrome p450
I3J16_RS28770	COG2124	cytochrome p450
I3J16_RS28775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J16_RS28780	COG0346	lactoylglutathione lyase activity
I3J16_RS28785	COG0640	Transcriptional regulator
I3J16_RS28795	COG2226	methyltransferase
I3J16_RS28805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J16_RS28855	COG0577	efflux transmembrane transporter activity
I3J16_RS28855	COG1136	(ABC) transporter
I3J16_RS28860	COG1136	(ABC) transporter
I3J16_RS28860	COG0577	efflux transmembrane transporter activity
I3J16_RS28875	COG0745	RESPONSE REGULATOR receiver
I3J16_RS28880	COG2205	protein histidine kinase activity
I3J16_RS28910	COG4948	Mandelate Racemase Muconate Lactonizing
I3J16_RS28945	COG2124	cytochrome p450
I3J16_RS28955	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS29065	COG2124	cytochrome p450
I3J16_RS29090	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J16_RS29125	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J16_RS29125	COG2319	Wd-40 repeat
I3J16_RS29130	COG1335	isochorismatase
I3J16_RS29170	COG3409	Peptidoglycan-binding domain 1 protein
I3J16_RS29175	COG3973	AAA domain
I3J16_RS29205	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J16_RS29210	COG5183	chlorophyll binding
I3J16_RS29210	COG2133	pyrroloquinoline quinone binding
I3J16_RS29235	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS29245	COG2201	protein-glutamate methylesterase activity
I3J16_RS29260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS29265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J16_RS29270	COG0010	Belongs to the arginase family
I3J16_RS29275	COG0367	asparagine synthase
I3J16_RS29295	COG0436	Aminotransferase
I3J16_RS29300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J16_RS29310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J16_RS29325	COG0583	DNA-binding transcription factor activity
I3J16_RS29370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J16_RS29370	COG2111	Na H antiporter
I3J16_RS29375	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J16_RS29380	COG0651	ATP synthesis coupled electron transport
I3J16_RS29395	COG1320	monovalent cation:proton antiporter activity
I3J16_RS29550	COG3959	Transketolase, thiamine diphosphate binding domain
I3J16_RS29555	COG3958	Transketolase
I3J16_RS29590	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J16_RS29595	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS29600	COG0277	FAD linked oxidase domain protein
I3J16_RS29605	COG1070	Carbohydrate kinase
I3J16_RS29650	COG2124	cytochrome p450
I3J16_RS29660	COG1011	Hydrolase
I3J16_RS29700	COG0789	Transcriptional regulator
I3J16_RS29710	COG3397	chitin binding
I3J16_RS29740	COG1132	(ABC) transporter
I3J16_RS29800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J16_RS29805	COG2124	cytochrome p450
I3J16_RS29820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J16_RS29840	COG3409	Peptidoglycan-binding domain 1 protein
I3J16_RS29840	COG3757	hydrolase, family 25
I3J16_RS29875	COG0488	(ABC) transporter
I3J16_RS29905	COG0698	ribose 5-phosphate isomerase
I3J16_RS29940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J16_RS29950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J16_RS29965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J16_RS29975	COG2267	carboxylic ester hydrolase activity
I3J16_RS30055	COG0477	Major facilitator Superfamily
I3J16_RS30100	COG1028	Short-chain dehydrogenase reductase Sdr
I3J16_RS30135	COG2226	methyltransferase
I3J16_RS30150	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J16_RS30165	COG3409	Peptidoglycan-binding domain 1 protein
I3J16_RS30205	COG0494	nUDIX hydrolase
I3J16_RS30220	COG3629	intracellular signal transduction
I3J16_RS30220	COG3903	Transcriptional regulator
I3J16_RS30245	COG1725	Transcriptional regulator
I3J16_RS30250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3J16_RS30260	COG1309	transcriptional regulator
I3J16_RS30285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J16_RS30335	COG2318	DinB family
I3J16_RS30430	COG2319	Wd-40 repeat
I3J16_RS30430	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J16_RS30460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J16_RS30465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J16_RS30480	COG0431	NADPH-dependent FMN reductase
I3J16_RS30490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS30495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS30500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J16_RS30535	COG0640	Transcriptional regulator
I3J16_RS30560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J16_RS30570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J16_RS30575	COG0301	tRNA thio-modification
I3J16_RS30605	COG1024	Enoyl-CoA hydratase
I3J16_RS30650	COG0110	maltose O-acetyltransferase activity
I3J16_RS30690	COG0477	Major facilitator Superfamily
I3J16_RS30730	COG0546	phosphoglycolate phosphatase activity
I3J16_RS30745	COG0363	glucosamine-6-phosphate deaminase activity
I3J16_RS30750	COG1940	carbohydrate kinase activity
I3J16_RS30775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J16_RS30785	COG4552	Acetyltransferase involved in intracellular survival and related
I3J16_RS30795	COG2816	NAD+ diphosphatase activity
I3J16_RS30805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J16_RS30810	COG1228	amidohydrolase
I3J16_RS30865	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J16_RS30870	COG1732	Glycine betaine
I3J16_RS30875	COG1174	glycine betaine transport
I3J16_RS30880	COG1125	glycine betaine transport
I3J16_RS30880	COG0517	IMP dehydrogenase activity
I3J16_RS30895	COG0076	glutamate decarboxylase activity
I3J16_RS30915	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J16_RS30920	COG1121	(ABC) transporter
I3J16_RS30965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J16_RS31110	COG1320	monovalent cation:proton antiporter activity
I3J16_RS31125	COG0651	ATP synthesis coupled electron transport
I3J16_RS31130	COG1006	Multisubunit Na H antiporter MnhC subunit