locus-tag	class	description
I3J19_RS00055	COG0475	glutathione-regulated potassium exporter activity
I3J19_RS00055	COG0569	domain protein
I3J19_RS00080	COG2814	Major facilitator Superfamily
I3J19_RS00105	COG1063	alcohol dehydrogenase
I3J19_RS00110	COG0156	8-amino-7-oxononanoate synthase activity
I3J19_RS00120	COG2018	Roadblock/LC7 domain
I3J19_RS00135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J19_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS00160	COG0531	amino acid
I3J19_RS00170	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS00175	COG0142	geranyltranstransferase activity
I3J19_RS00190	COG2124	cytochrome p450
I3J19_RS00220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J19_RS00245	COG4310	Domain of unknown function (DUF2172)
I3J19_RS00260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J19_RS00270	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS00270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J19_RS00305	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS00310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J19_RS00345	COG0473	3-isopropylmalate dehydrogenase activity
I3J19_RS00385	COG1846	Transcriptional regulator
I3J19_RS00400	COG0542	response to heat
I3J19_RS00405	COG2208	phosphoserine phosphatase activity
I3J19_RS00405	COG2172	sigma factor antagonist activity
I3J19_RS00405	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J19_RS00420	COG1653	transport
I3J19_RS00425	COG1233	COG1233 Phytoene dehydrogenase and related
I3J19_RS00450	COG1233	COG1233 Phytoene dehydrogenase and related
I3J19_RS00455	COG2130	NADP-dependent
I3J19_RS00460	COG2376	Dihydroxyacetone kinase
I3J19_RS00465	COG2376	Dihydroxyacetone kinase
I3J19_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS00525	COG2124	cytochrome p450
I3J19_RS00560	COG1124	(ABC) transporter
I3J19_RS00565	COG0444	Belongs to the ABC transporter superfamily
I3J19_RS00570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS00575	COG0601	transmembrane transport
I3J19_RS00585	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS00590	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS00620	COG0517	IMP dehydrogenase activity
I3J19_RS00620	COG1125	glycine betaine transport
I3J19_RS00625	COG3458	cephalosporin-C deacetylase activity
I3J19_RS00640	COG1174	glycine betaine transport
I3J19_RS00645	COG1174	glycine betaine transport
I3J19_RS00655	COG1309	transcriptional regulator
I3J19_RS00675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J19_RS00690	COG2124	cytochrome p450
I3J19_RS00715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J19_RS00735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J19_RS00735	COG1024	Enoyl-CoA hydratase
I3J19_RS00760	COG2124	cytochrome p450
I3J19_RS00795	COG0463	Glycosyl transferase, family 2
I3J19_RS00810	COG0402	S-adenosylhomocysteine deaminase activity
I3J19_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS00880	COG2326	polyphosphate kinase activity
I3J19_RS00885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J19_RS00935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J19_RS00940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J19_RS00945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J19_RS00995	COG0183	Belongs to the thiolase family
I3J19_RS01015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J19_RS01020	COG1376	ErfK ybiS ycfS ynhG family protein
I3J19_RS01040	COG0535	radical SAM domain protein
I3J19_RS01050	COG3424	synthase
I3J19_RS01060	COG3959	Transketolase, thiamine diphosphate binding domain
I3J19_RS01095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J19_RS01100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J19_RS01185	COG1131	(ABC) transporter
I3J19_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS01235	COG1309	transcriptional regulator
I3J19_RS01270	COG3903	Transcriptional regulator
I3J19_RS01270	COG3629	intracellular signal transduction
I3J19_RS01275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J19_RS01280	COG1597	lipid kinase activity
I3J19_RS01300	COG0574	Belongs to the PEP-utilizing enzyme family
I3J19_RS01300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J19_RS01340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J19_RS01345	COG0477	Major facilitator Superfamily
I3J19_RS01365	COG1174	glycine betaine transport
I3J19_RS01370	COG1174	glycine betaine transport
I3J19_RS01405	COG2957	Belongs to the agmatine deiminase family
I3J19_RS01425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J19_RS01465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J19_RS01475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J19_RS01485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS01500	COG2207	Transcriptional regulator
I3J19_RS01505	COG1120	ATPase activity
I3J19_RS01510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J19_RS01525	COG4552	Acetyltransferase involved in intracellular survival and related
I3J19_RS01545	COG2197	response regulator
I3J19_RS01550	COG0154	amidase activity
I3J19_RS01555	COG0477	Major facilitator Superfamily
I3J19_RS01560	COG0579	oxidoreductase
I3J19_RS01580	COG2755	lipolytic protein G-D-S-L family
I3J19_RS01580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J19_RS01595	COG0745	RESPONSE REGULATOR receiver
I3J19_RS01600	COG2205	protein histidine kinase activity
I3J19_RS01615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J19_RS01645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J19_RS01650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J19_RS01660	COG1609	Transcriptional regulator
I3J19_RS01665	COG0596	Alpha beta hydrolase
I3J19_RS01680	COG3572	ergothioneine biosynthetic process
I3J19_RS01685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J19_RS01690	COG0121	glutamine amidotransferase
I3J19_RS01695	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J19_RS01700	COG2182	Extracellular solute-binding protein
I3J19_RS01705	COG3360	Dodecin
I3J19_RS01715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J19_RS01735	COG5001	Diguanylate cyclase
I3J19_RS01735	COG3300	MHYT domain
I3J19_RS01780	COG3275	phosphorelay sensor kinase activity
I3J19_RS01785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J19_RS01800	COG3279	Response regulator of the LytR AlgR family
I3J19_RS01815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J19_RS01870	COG0297	glycogen (starch) synthase activity
I3J19_RS01890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J19_RS01900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J19_RS01910	COG3845	ABC transporter
I3J19_RS01945	COG2205	protein histidine kinase activity
I3J19_RS01950	COG0745	RESPONSE REGULATOR receiver
I3J19_RS01980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J19_RS02000	COG0248	Ppx GppA phosphatase
I3J19_RS02045	COG1175	transmembrane transport
I3J19_RS02050	COG0395	ABC-type sugar transport system, permease component
I3J19_RS02065	COG1051	belongs to the nudix hydrolase family
I3J19_RS02070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J19_RS02080	COG2318	DinB family
I3J19_RS02095	COG3251	PFAM MbtH domain protein
I3J19_RS02100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J19_RS02110	COG0667	Aldo Keto reductase
I3J19_RS02165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J19_RS02170	COG1129	ABC transporter
I3J19_RS02170	COG0842	Transport permease protein
I3J19_RS02195	COG2072	flavoprotein involved in K transport
I3J19_RS02220	COG1556	Lactate utilization protein
I3J19_RS02225	COG1139	Iron-sulfur cluster binding protein
I3J19_RS02230	COG0247	lactate metabolic process
I3J19_RS02275	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS02310	COG0500	methyltransferase
I3J19_RS02315	COG4981	capsule polysaccharide biosynthetic process
I3J19_RS02365	COG0477	Major facilitator Superfamily
I3J19_RS02385	COG2226	methyltransferase
I3J19_RS02395	COG0187	DNA topoisomerase II activity
I3J19_RS02435	COG0673	inositol 2-dehydrogenase activity
I3J19_RS02480	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS02485	COG2850	peptidyl-arginine hydroxylation
I3J19_RS02545	COG3511	phospholipase C
I3J19_RS02635	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS02680	COG1116	anion transmembrane transporter activity
I3J19_RS02690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J19_RS02695	COG4948	Mandelate Racemase Muconate Lactonizing
I3J19_RS02700	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS02735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J19_RS02740	COG1309	transcriptional regulator
I3J19_RS02750	COG0741	lytic transglycosylase activity
I3J19_RS02750	COG0739	heme binding
I3J19_RS02750	COG1196	nuclear chromosome segregation
I3J19_RS02760	COG2365	Tyrosine phosphatase family
I3J19_RS02790	COG1657	PFAM Prenyltransferase squalene oxidase
I3J19_RS02800	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J19_RS02810	COG1562	ergosterol biosynthetic process
I3J19_RS02815	COG1134	teichoic acid transport
I3J19_RS02830	COG0371	Dehydrogenase
I3J19_RS02855	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J19_RS02885	COG2183	response to ionizing radiation
I3J19_RS02900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J19_RS02910	COG2936	dipeptidyl-peptidase activity
I3J19_RS02930	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J19_RS02930	COG1024	Enoyl-CoA hydratase
I3J19_RS02935	COG0183	Belongs to the thiolase family
I3J19_RS02940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J19_RS02945	COG3268	Saccharopine dehydrogenase
I3J19_RS02950	COG1515	deoxyribonuclease V activity
I3J19_RS02965	COG0488	(ABC) transporter
I3J19_RS02970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J19_RS03010	COG1793	dna ligase
I3J19_RS03065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J19_RS03105	COG3012	SEC-C Motif Domain Protein
I3J19_RS03135	COG1609	Transcriptional regulator
I3J19_RS03140	COG3345	alpha-galactosidase
I3J19_RS03230	COG0475	glutathione-regulated potassium exporter activity
I3J19_RS03245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J19_RS03250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J19_RS03255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J19_RS03350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J19_RS03370	COG0673	inositol 2-dehydrogenase activity
I3J19_RS03375	COG4213	ABC transporter substrate-binding protein
I3J19_RS03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J19_RS03385	COG1129	ABC transporter
I3J19_RS03390	COG1940	carbohydrate kinase activity
I3J19_RS03400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J19_RS03405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J19_RS03425	COG1595	DNA-templated transcription, initiation
I3J19_RS03435	COG3250	beta-galactosidase activity
I3J19_RS03445	COG3250	beta-galactosidase activity
I3J19_RS03460	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J19_RS03465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J19_RS03475	COG0656	L-ascorbic acid biosynthetic process
I3J19_RS03485	COG1793	dna ligase
I3J19_RS03535	COG1063	alcohol dehydrogenase
I3J19_RS03605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J19_RS03610	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J19_RS03620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J19_RS03625	COG2362	D-Aminopeptidase
I3J19_RS03680	COG0604	alcohol dehydrogenase
I3J19_RS03685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS03685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS03700	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS03705	COG0688	phosphatidylethanolamine metabolic process
I3J19_RS03715	COG1929	Belongs to the glycerate kinase type-1 family
I3J19_RS03730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J19_RS03735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J19_RS03745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J19_RS03760	COG0483	inositol monophosphate 1-phosphatase activity
I3J19_RS03765	COG0095	Lipoate-protein ligase
I3J19_RS03775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J19_RS03780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J19_RS03810	COG0405	Gamma-glutamyltransferase
I3J19_RS03820	COG0765	amino acid transport
I3J19_RS03825	COG0765	amino acid transport
I3J19_RS03830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J19_RS03835	COG1126	abc transporter atp-binding protein
I3J19_RS03855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J19_RS03865	COG1940	carbohydrate kinase activity
I3J19_RS03885	COG2188	Transcriptional regulator
I3J19_RS03890	COG0673	inositol 2-dehydrogenase activity
I3J19_RS03900	COG2197	response regulator
I3J19_RS03905	COG4585	Histidine kinase
I3J19_RS03920	COG4266	Belongs to the allantoicase family
I3J19_RS03925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J19_RS03930	COG1414	Transcriptional regulator
I3J19_RS03945	COG0746	molybdenum cofactor guanylyltransferase activity
I3J19_RS03955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J19_RS03970	COG1288	antiporter activity
I3J19_RS04000	COG2351	hydroxyisourate hydrolase activity
I3J19_RS04025	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS04030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J19_RS04035	COG2197	response regulator
I3J19_RS04050	COG3409	Peptidoglycan-binding domain 1 protein
I3J19_RS04070	COG1404	Belongs to the peptidase S8 family
I3J19_RS04085	COG0243	molybdopterin cofactor binding
I3J19_RS04120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J19_RS04135	COG2345	Transcriptional regulator
I3J19_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS04155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS04170	COG2197	response regulator
I3J19_RS04175	COG1132	(ABC) transporter
I3J19_RS04180	COG1132	(ABC) transporter
I3J19_RS04190	COG0515	serine threonine protein kinase
I3J19_RS04200	COG1609	Transcriptional regulator
I3J19_RS04245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J19_RS04260	COG3835	regulator
I3J19_RS04265	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J19_RS04275	COG3842	ATPase activity
I3J19_RS04290	COG1802	Transcriptional regulator
I3J19_RS04310	COG0028	Belongs to the TPP enzyme family
I3J19_RS04340	COG1162	GTPase activity
I3J19_RS04365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J19_RS04395	COG3290	protein histidine kinase activity
I3J19_RS04435	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS04440	COG3284	Transcriptional regulator
I3J19_RS04460	COG0175	sulfate reduction
I3J19_RS04465	COG0529	Catalyzes the synthesis of activated sulfate
I3J19_RS04485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J19_RS04490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J19_RS04525	COG1175	transmembrane transport
I3J19_RS04600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J19_RS04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J19_RS04630	COG1764	response to oxidative stress
I3J19_RS04635	COG1846	Transcriptional regulator
I3J19_RS04655	COG3220	belongs to the UPF0276 family
I3J19_RS04675	COG3253	May function as heme-dependent peroxidase
I3J19_RS04680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J19_RS04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J19_RS04695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J19_RS04715	COG0183	Belongs to the thiolase family
I3J19_RS04720	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J19_RS04720	COG1024	Enoyl-CoA hydratase
I3J19_RS04730	COG0531	amino acid
I3J19_RS04735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J19_RS04740	COG4214	carbohydrate transport
I3J19_RS04750	COG4213	ABC transporter substrate-binding protein
I3J19_RS04755	COG1940	carbohydrate kinase activity
I3J19_RS04760	COG0395	ABC-type sugar transport system, permease component
I3J19_RS04765	COG1175	transmembrane transport
I3J19_RS04770	COG1653	transport
I3J19_RS04780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J19_RS04785	COG1522	sequence-specific DNA binding
I3J19_RS04805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J19_RS04850	COG1024	Enoyl-CoA hydratase
I3J19_RS04855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J19_RS04865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J19_RS04885	COG2040	homocysteine
I3J19_RS04905	COG1799	cell septum assembly
I3J19_RS04925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J19_RS04945	COG4689	acetoacetate decarboxylase
I3J19_RS04975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J19_RS04990	COG0745	RESPONSE REGULATOR receiver
I3J19_RS04995	COG2205	protein histidine kinase activity
I3J19_RS05020	COG0756	dUTP diphosphatase activity
I3J19_RS05030	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J19_RS05030	COG1136	(ABC) transporter
I3J19_RS05065	COG1136	(ABC) transporter
I3J19_RS05065	COG0577	efflux transmembrane transporter activity
I3J19_RS05075	COG0569	domain protein
I3J19_RS05080	COG0531	amino acid
I3J19_RS05085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J19_RS05095	COG0483	inositol monophosphate 1-phosphatase activity
I3J19_RS05100	COG2264	protein methyltransferase activity
I3J19_RS05115	COG0494	nUDIX hydrolase
I3J19_RS05145	COG0142	geranyltranstransferase activity
I3J19_RS05200	COG2409	Drug exporters of the RND superfamily
I3J19_RS05220	COG3903	Transcriptional regulator
I3J19_RS05220	COG3629	intracellular signal transduction
I3J19_RS05230	COG2264	protein methyltransferase activity
I3J19_RS05290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J19_RS05295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS05300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J19_RS05315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J19_RS05325	COG0702	epimerase
I3J19_RS05340	COG1435	thymidine kinase activity
I3J19_RS05355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J19_RS05355	COG1042	CoA-binding domain protein
I3J19_RS05355	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J19_RS05360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J19_RS05365	COG1802	Transcriptional regulator
I3J19_RS05370	COG1196	nuclear chromosome segregation
I3J19_RS05370	COG0739	heme binding
I3J19_RS05370	COG0741	lytic transglycosylase activity
I3J19_RS05380	COG0612	Peptidase, M16
I3J19_RS05385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J19_RS05395	COG0372	Belongs to the citrate synthase family
I3J19_RS05405	COG3290	protein histidine kinase activity
I3J19_RS05410	COG4565	transcriptional regulatory protein
I3J19_RS05415	COG0187	DNA topoisomerase II activity
I3J19_RS05430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J19_RS05435	COG2186	Transcriptional regulator
I3J19_RS05440	COG1131	(ABC) transporter
I3J19_RS05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J19_RS05495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J19_RS05500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J19_RS05505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J19_RS05535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J19_RS05545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J19_RS05550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J19_RS05560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J19_RS05580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J19_RS05585	COG2358	TRAP transporter, solute receptor (TAXI family
I3J19_RS05590	COG2205	protein histidine kinase activity
I3J19_RS05595	COG0745	RESPONSE REGULATOR receiver
I3J19_RS05600	COG1126	abc transporter atp-binding protein
I3J19_RS05605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J19_RS05610	COG0765	amino acid transport
I3J19_RS05615	COG0765	amino acid transport
I3J19_RS05620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J19_RS05635	COG2137	regulation of response to DNA damage stimulus
I3J19_RS05675	COG1201	RNA secondary structure unwinding
I3J19_RS05680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J19_RS05685	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS05690	COG0783	Belongs to the Dps family
I3J19_RS05695	COG1396	sequence-specific DNA binding
I3J19_RS05700	COG1546	Belongs to the CinA family
I3J19_RS05700	COG1058	Belongs to the CinA family
I3J19_RS05710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J19_RS05720	COG1674	ftsk spoiiie
I3J19_RS05730	COG5002	protein histidine kinase activity
I3J19_RS05730	COG0784	Response regulator, receiver
I3J19_RS05735	COG2208	phosphoserine phosphatase activity
I3J19_RS05735	COG2770	Histidine kinase
I3J19_RS05760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J19_RS05765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J19_RS05770	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J19_RS05790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J19_RS05795	COG0612	Peptidase, M16
I3J19_RS05800	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J19_RS05805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J19_RS05815	COG1674	ftsk spoiiie
I3J19_RS05830	COG1404	Belongs to the peptidase S8 family
I3J19_RS05845	COG1404	Belongs to the peptidase S8 family
I3J19_RS05850	COG3266	domain, Protein
I3J19_RS05870	COG0455	bacterial-type flagellum organization
I3J19_RS05875	COG0747	negative chemotaxis
I3J19_RS05880	COG0601	transmembrane transport
I3J19_RS05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS05905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J19_RS05910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J19_RS05920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J19_RS05935	COG0779	Required for maturation of 30S ribosomal subunits
I3J19_RS05955	COG0442	prolyl-tRNA aminoacylation
I3J19_RS05970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J19_RS05975	COG0750	zinc metalloprotease
I3J19_RS05980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J19_RS05995	COG2508	Transcriptional regulator
I3J19_RS06025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J19_RS06030	COG1177	transmembrane transport
I3J19_RS06035	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J19_RS06040	COG3842	ATPase activity
I3J19_RS06065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J19_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS06090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS06095	COG1136	(ABC) transporter
I3J19_RS06110	COG3842	ATPase activity
I3J19_RS06125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J19_RS06130	COG0575	Belongs to the CDS family
I3J19_RS06135	COG0233	cytoplasmic translational termination
I3J19_RS06140	COG0528	UMP kinase activity
I3J19_RS06145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J19_RS06150	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J19_RS06165	COG1191	sigma factor activity
I3J19_RS06180	COG0792	nuclease activity
I3J19_RS06190	COG0681	Belongs to the peptidase S26 family
I3J19_RS06205	COG0681	Belongs to the peptidase S26 family
I3J19_RS06210	COG0335	large ribosomal subunit rRNA binding
I3J19_RS06215	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J19_RS06220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J19_RS06225	COG1837	Belongs to the UPF0109 family
I3J19_RS06230	COG0228	four-way junction DNA binding
I3J19_RS06240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J19_RS06250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J19_RS06280	COG4552	Acetyltransferase involved in intracellular survival and related
I3J19_RS06285	COG0477	Major facilitator Superfamily
I3J19_RS06290	COG1196	nuclear chromosome segregation
I3J19_RS06305	COG1254	Belongs to the acylphosphatase family
I3J19_RS06310	COG2340	Cysteine-rich secretory protein family
I3J19_RS06315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J19_RS06320	COG0571	ribonuclease III activity
I3J19_RS06325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J19_RS06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J19_RS06345	COG0742	ribosomal rna small subunit methyltransferase
I3J19_RS06355	COG1461	Dihydroxyacetone kinase
I3J19_RS06360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J19_RS06365	COG0351	phosphomethylpyrimidine kinase
I3J19_RS06380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J19_RS06385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J19_RS06395	COG1920	GTP binding
I3J19_RS06405	COG0776	regulation of translation
I3J19_RS06415	COG0066	3-isopropylmalate dehydratase activity
I3J19_RS06420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J19_RS06425	COG1414	Transcriptional regulator
I3J19_RS06455	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J19_RS06460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J19_RS06465	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J19_RS06475	COG5002	protein histidine kinase activity
I3J19_RS06480	COG2018	Roadblock/LC7 domain
I3J19_RS06500	COG2018	Roadblock/LC7 domain
I3J19_RS06520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J19_RS06540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J19_RS06550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J19_RS06555	COG0477	Major facilitator Superfamily
I3J19_RS06565	COG2957	Belongs to the agmatine deiminase family
I3J19_RS06570	COG0804	urea catabolic process
I3J19_RS06580	COG0831	urea catabolic process
I3J19_RS06580	COG0832	Belongs to the urease beta subunit family
I3J19_RS06605	COG0300	oxidoreductase activity
I3J19_RS06615	COG3321	synthase
I3J19_RS06615	COG0604	alcohol dehydrogenase
I3J19_RS06630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J19_RS06635	COG0473	3-isopropylmalate dehydrogenase activity
I3J19_RS06650	COG1082	Xylose isomerase domain protein TIM barrel
I3J19_RS06710	COG0640	Transcriptional regulator
I3J19_RS06715	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS06720	COG0506	proline dehydrogenase activity
I3J19_RS06725	COG2508	Transcriptional regulator
I3J19_RS06725	COG2508	Transcriptional regulator
I3J19_RS06730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J19_RS06735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J19_RS06740	COG0440	acetolactate synthase activity
I3J19_RS06760	COG0667	Aldo Keto reductase
I3J19_RS06765	COG2133	pyrroloquinoline quinone binding
I3J19_RS06775	COG1672	PFAM Archaeal ATPase
I3J19_RS06775	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J19_RS06790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J19_RS06795	COG2409	Drug exporters of the RND superfamily
I3J19_RS06805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J19_RS06815	COG0154	amidase activity
I3J19_RS06820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J19_RS06830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J19_RS06840	COG4221	oxidoreductase activity
I3J19_RS06845	COG1611	Belongs to the LOG family
I3J19_RS06855	COG0482	sulfurtransferase activity
I3J19_RS06880	COG2860	membrane
I3J19_RS06885	COG4608	Belongs to the ABC transporter superfamily
I3J19_RS06890	COG0444	Belongs to the ABC transporter superfamily
I3J19_RS06895	COG0601	transmembrane transport
I3J19_RS06900	COG0747	negative chemotaxis
I3J19_RS06905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS06925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J19_RS06930	COG0509	glycine decarboxylation via glycine cleavage system
I3J19_RS06935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J19_RS06940	COG1760	l-serine dehydratase
I3J19_RS06950	COG2856	Zn peptidase
I3J19_RS07080	COG1024	Enoyl-CoA hydratase
I3J19_RS07095	COG1132	(ABC) transporter
I3J19_RS07100	COG1132	(ABC) transporter
I3J19_RS07110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J19_RS07145	COG2197	response regulator
I3J19_RS07150	COG4585	Histidine kinase
I3J19_RS07160	COG0058	SHG alpha-glucan phosphorylase activity
I3J19_RS07165	COG0366	Alpha amylase catalytic
I3J19_RS07170	COG0366	Alpha amylase catalytic
I3J19_RS07180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J19_RS07195	COG1301	dicarboxylic acid transport
I3J19_RS07200	COG3290	protein histidine kinase activity
I3J19_RS07205	COG4565	transcriptional regulatory protein
I3J19_RS07210	COG0181	hydroxymethylbilane synthase activity
I3J19_RS07240	COG1175	transmembrane transport
I3J19_RS07250	COG0205	6-phosphofructokinase activity
I3J19_RS07255	COG0857	belongs to the CobB CobQ family
I3J19_RS07255	COG0280	phosphate acetyltransferase
I3J19_RS07260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J19_RS07295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS07295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS07340	COG0745	RESPONSE REGULATOR receiver
I3J19_RS07355	COG0183	Belongs to the thiolase family
I3J19_RS07375	COG1131	(ABC) transporter
I3J19_RS07410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J19_RS07425	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J19_RS07440	COG4585	Histidine kinase
I3J19_RS07445	COG2197	response regulator
I3J19_RS07455	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J19_RS07475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J19_RS07505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J19_RS07515	COG0494	nUDIX hydrolase
I3J19_RS07530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J19_RS07535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J19_RS07540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J19_RS07545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J19_RS07550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J19_RS07555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J19_RS07560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J19_RS07580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J19_RS07585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J19_RS07595	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J19_RS07600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J19_RS07605	COG0254	rRNA binding
I3J19_RS07610	COG1316	TRANSCRIPTIONal
I3J19_RS07625	COG0083	homoserine kinase activity
I3J19_RS07630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J19_RS07635	COG0460	homoserine dehydrogenase
I3J19_RS07640	COG0019	diaminopimelate decarboxylase activity
I3J19_RS07645	COG0018	arginyl-trna synthetase
I3J19_RS07785	COG2367	Beta-lactamase
I3J19_RS07790	COG1686	Belongs to the peptidase S11 family
I3J19_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS07805	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J19_RS07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J19_RS07830	COG2192	nodulation
I3J19_RS07840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J19_RS07850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J19_RS07860	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J19_RS07870	COG0768	penicillin binding
I3J19_RS07880	COG0367	asparagine synthase
I3J19_RS07885	COG0010	Belongs to the arginase family
I3J19_RS07890	COG2175	clavaminate synthase activity
I3J19_RS07930	COG0697	spore germination
I3J19_RS07935	COG0456	acetyltransferase
I3J19_RS07940	COG0747	negative chemotaxis
I3J19_RS07950	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J19_RS07955	COG0768	penicillin binding
I3J19_RS07960	COG0768	penicillin binding
I3J19_RS07965	COG2124	cytochrome p450
I3J19_RS07975	COG2205	protein histidine kinase activity
I3J19_RS07980	COG0745	RESPONSE REGULATOR receiver
I3J19_RS08000	COG2072	flavoprotein involved in K transport
I3J19_RS08005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J19_RS08010	COG3285	dna ligase
I3J19_RS08010	COG1793	dna ligase
I3J19_RS08015	COG1793	dna ligase
I3J19_RS08070	COG0768	penicillin binding
I3J19_RS08100	COG2318	DinB family
I3J19_RS08135	COG2205	protein histidine kinase activity
I3J19_RS08155	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J19_RS08160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J19_RS08170	COG0745	RESPONSE REGULATOR receiver
I3J19_RS08175	COG2205	protein histidine kinase activity
I3J19_RS08180	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J19_RS08180	COG0567	Dehydrogenase, E1 component
I3J19_RS08190	COG2255	four-way junction helicase activity
I3J19_RS08225	COG0604	alcohol dehydrogenase
I3J19_RS08245	COG1126	abc transporter atp-binding protein
I3J19_RS08250	COG4106	trans-aconitate 2-methyltransferase activity
I3J19_RS08270	COG0494	nUDIX hydrolase
I3J19_RS08280	COG5640	endopeptidase activity
I3J19_RS08300	COG0142	geranyltranstransferase activity
I3J19_RS08335	COG1597	lipid kinase activity
I3J19_RS08350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J19_RS08355	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J19_RS08360	COG0395	ABC-type sugar transport system, permease component
I3J19_RS08365	COG1175	transmembrane transport
I3J19_RS08370	COG2182	Extracellular solute-binding protein
I3J19_RS08375	COG2188	Transcriptional regulator
I3J19_RS08400	COG0242	peptide deformylase activity
I3J19_RS08420	COG5662	AntiSigma factor
I3J19_RS08425	COG1595	DNA-templated transcription, initiation
I3J19_RS08435	COG2135	peptidase activity
I3J19_RS08445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J19_RS08455	COG2076	Multidrug Resistance protein
I3J19_RS08465	COG0483	inositol monophosphate 1-phosphatase activity
I3J19_RS08475	COG0753	catalase activity
I3J19_RS08500	COG1615	UPF0182 protein
I3J19_RS08510	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J19_RS08550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J19_RS08590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J19_RS08645	COG0601	transmembrane transport
I3J19_RS08650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS08655	COG0747	negative chemotaxis
I3J19_RS08665	COG0596	Alpha beta hydrolase
I3J19_RS08665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J19_RS08695	COG0513	Belongs to the DEAD box helicase family
I3J19_RS08720	COG1432	Conserved Protein
I3J19_RS08730	COG2095	MarC family integral membrane protein
I3J19_RS08750	COG0598	Magnesium transport protein CorA
I3J19_RS08785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J19_RS08790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J19_RS08800	COG1595	DNA-templated transcription, initiation
I3J19_RS08815	COG1024	Enoyl-CoA hydratase
I3J19_RS08820	COG0519	Catalyzes the synthesis of GMP from XMP
I3J19_RS08830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J19_RS08835	COG1611	Belongs to the LOG family
I3J19_RS08840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J19_RS08880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J19_RS08895	COG4608	Belongs to the ABC transporter superfamily
I3J19_RS08900	COG0444	Belongs to the ABC transporter superfamily
I3J19_RS08905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS08910	COG0601	transmembrane transport
I3J19_RS08925	COG4608	Belongs to the ABC transporter superfamily
I3J19_RS08930	COG0444	Belongs to the ABC transporter superfamily
I3J19_RS08940	COG4166	transmembrane transport
I3J19_RS08945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J19_RS08950	COG1217	gtp-binding protein TYPA
I3J19_RS08970	COG1053	succinate dehydrogenase
I3J19_RS09020	COG0012	GTP binding
I3J19_RS09035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J19_RS09040	COG0531	amino acid
I3J19_RS09045	COG1570	exodeoxyribonuclease VII activity
I3J19_RS09050	COG1722	exodeoxyribonuclease VII activity
I3J19_RS09055	COG0778	Nitroreductase
I3J19_RS09080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J19_RS09080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J19_RS09090	COG0114	fumarate hydratase activity
I3J19_RS09110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J19_RS09130	COG1136	(ABC) transporter
I3J19_RS09145	COG0450	alkyl hydroperoxide reductase
I3J19_RS09150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J19_RS09165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J19_RS09170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J19_RS09175	COG0667	Aldo Keto reductase
I3J19_RS09200	COG2885	chlorophyll binding
I3J19_RS09220	COG2197	response regulator
I3J19_RS09225	COG4585	Histidine kinase
I3J19_RS09255	COG2894	cell division
I3J19_RS09280	COG2610	gluconate transmembrane transporter activity
I3J19_RS09285	COG0251	oxidation-reduction process
I3J19_RS09290	COG1414	Transcriptional regulator
I3J19_RS09305	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J19_RS09365	COG0492	ferredoxin-NADP+ reductase activity
I3J19_RS09400	COG0728	peptidoglycan biosynthetic process
I3J19_RS09410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J19_RS09415	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS09455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J19_RS09465	COG1309	transcriptional regulator
I3J19_RS09470	COG1331	Highly conserved protein containing a thioredoxin domain
I3J19_RS09500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J19_RS09510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J19_RS09520	COG2188	Transcriptional regulator
I3J19_RS09540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J19_RS09580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J19_RS09600	COG1064	alcohol dehydrogenase
I3J19_RS09615	COG2986	histidine ammonia-lyase
I3J19_RS09625	COG1024	Enoyl-CoA hydratase
I3J19_RS09640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J19_RS09650	COG0424	maF-like protein
I3J19_RS09655	COG4770	biotin carboxylase activity
I3J19_RS09685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J19_RS09715	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS09720	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS09735	COG1595	DNA-templated transcription, initiation
I3J19_RS09740	COG0745	RESPONSE REGULATOR receiver
I3J19_RS09745	COG2205	protein histidine kinase activity
I3J19_RS09770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J19_RS09785	COG0583	DNA-binding transcription factor activity
I3J19_RS09790	COG2814	Major facilitator Superfamily
I3J19_RS09825	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J19_RS09830	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J19_RS09835	COG3845	ABC transporter
I3J19_RS09840	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J19_RS09845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J19_RS09845	COG1473	amidohydrolase
I3J19_RS09855	COG2089	acid synthase
I3J19_RS09860	COG1083	cytidylyl-transferase
I3J19_RS09870	COG1216	Glycosyl transferase, family 2
I3J19_RS09885	COG0516	GMP reductase activity
I3J19_RS09885	COG0517	IMP dehydrogenase activity
I3J19_RS09900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS09900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS09915	COG1595	DNA-templated transcription, initiation
I3J19_RS09925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J19_RS09930	COG2009	succinate dehydrogenase
I3J19_RS09940	COG1053	succinate dehydrogenase
I3J19_RS09945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J19_RS09955	COG1408	metallophosphoesterase
I3J19_RS09965	COG1686	Belongs to the peptidase S11 family
I3J19_RS09970	COG1295	ribonuclease BN
I3J19_RS09975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J19_RS10000	COG0180	Tryptophanyl-tRNA synthetase
I3J19_RS10005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J19_RS10010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J19_RS10015	COG0754	glutathionylspermidine amidase activity
I3J19_RS10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J19_RS10065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J19_RS10075	COG0039	L-malate dehydrogenase activity
I3J19_RS10090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J19_RS10105	COG0138	bifunctional purine biosynthesis protein purh
I3J19_RS10135	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J19_RS10140	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J19_RS10150	COG0714	Associated with various cellular activities
I3J19_RS10165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS10165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J19_RS10175	COG0739	heme binding
I3J19_RS10195	COG2197	response regulator
I3J19_RS10220	COG0519	Catalyzes the synthesis of GMP from XMP
I3J19_RS10220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J19_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS10260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J19_RS10270	COG0516	GMP reductase activity
I3J19_RS10280	COG1595	DNA-templated transcription, initiation
I3J19_RS10285	COG2197	response regulator
I3J19_RS10295	COG0583	DNA-binding transcription factor activity
I3J19_RS10310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J19_RS10315	COG0459	protein refolding
I3J19_RS10320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J19_RS10325	COG0726	polysaccharide deacetylase
I3J19_RS10335	COG4941	Belongs to the sigma-70 factor family
I3J19_RS10360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J19_RS10385	COG0802	atpase or kinase
I3J19_RS10395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J19_RS10415	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J19_RS10420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J19_RS10425	COG1072	(Pantothenic acid kinase))
I3J19_RS10430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J19_RS10435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J19_RS10440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J19_RS10445	COG0488	(ABC) transporter
I3J19_RS10455	COG0101	tRNA pseudouridine synthase activity
I3J19_RS10460	COG0203	ribosomal protein L17
I3J19_RS10465	COG0202	RNA polymerase activity
I3J19_RS10470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J19_RS10475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J19_RS10480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J19_RS10485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J19_RS10495	COG0563	adenylate kinase activity
I3J19_RS10505	COG0200	Binds to the 23S rRNA
I3J19_RS10510	COG1841	ribosomal large subunit assembly
I3J19_RS10515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J19_RS10520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J19_RS10525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J19_RS10530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J19_RS10535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J19_RS10540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J19_RS10545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J19_RS10550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J19_RS10555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J19_RS10560	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J19_RS10565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J19_RS10570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J19_RS10575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J19_RS10580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J19_RS10585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J19_RS10590	COG0089	rRNA binding
I3J19_RS10595	COG0088	Forms part of the polypeptide exit tunnel
I3J19_RS10600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J19_RS10605	COG0051	transcription antitermination factor activity, RNA binding
I3J19_RS10615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J19_RS10620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J19_RS10625	COG0049	tRNA binding
I3J19_RS10630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J19_RS10635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J19_RS10640	COG0085	RNA polymerase activity
I3J19_RS10645	COG0222	ribosome binding
I3J19_RS10650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J19_RS10655	COG0081	regulation of translation
I3J19_RS10660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J19_RS10670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J19_RS10680	COG0436	Aminotransferase
I3J19_RS10685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J19_RS10690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J19_RS10700	COG2030	dehydratase
I3J19_RS10705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J19_RS10725	COG0702	epimerase
I3J19_RS10745	COG1666	GTP binding
I3J19_RS10750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J19_RS10760	COG3304	Inner membrane component domain
I3J19_RS10765	COG0501	Belongs to the peptidase M48B family
I3J19_RS10770	COG1007	ATP synthesis coupled electron transport
I3J19_RS10785	COG0713	ATP synthesis coupled electron transport
I3J19_RS10790	COG0839	Belongs to the complex I subunit 6 family
I3J19_RS10795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J19_RS10805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10820	COG4585	Histidine kinase
I3J19_RS10835	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J19_RS10835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J19_RS10840	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J19_RS10865	COG1733	regulation of RNA biosynthetic process
I3J19_RS10880	COG2234	aminopeptidase activity
I3J19_RS10880	COG4935	Belongs to the peptidase S8 family
I3J19_RS10905	COG0142	geranyltranstransferase activity
I3J19_RS10910	COG2936	dipeptidyl-peptidase activity
I3J19_RS10915	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J19_RS10920	COG1007	ATP synthesis coupled electron transport
I3J19_RS10930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J19_RS10935	COG0713	ATP synthesis coupled electron transport
I3J19_RS10940	COG0839	Belongs to the complex I subunit 6 family
I3J19_RS10945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J19_RS10955	COG1034	ATP synthesis coupled electron transport
I3J19_RS10960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J19_RS10970	COG0649	NAD binding
I3J19_RS10975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS10980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J19_RS11010	COG2226	methyltransferase
I3J19_RS11020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J19_RS11025	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J19_RS11030	COG1278	Cold shock
I3J19_RS11035	COG1823	symporter activity
I3J19_RS11055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J19_RS11065	COG0163	prenyltransferase activity
I3J19_RS11070	COG0109	protoheme IX farnesyltransferase activity
I3J19_RS11075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J19_RS11085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J19_RS11090	COG1333	cytochrome c biogenesis protein
I3J19_RS11095	COG0785	Cytochrome C biogenesis protein
I3J19_RS11100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J19_RS11105	COG0406	alpha-ribazole phosphatase activity
I3J19_RS11110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J19_RS11125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J19_RS11135	COG1742	UPF0060 membrane protein
I3J19_RS11150	COG0402	S-adenosylhomocysteine deaminase activity
I3J19_RS11155	COG1690	Belongs to the RtcB family
I3J19_RS11195	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J19_RS11200	COG0626	cystathionine gamma-synthase activity
I3J19_RS11215	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J19_RS11220	COG0018	arginyl-trna synthetase
I3J19_RS11240	COG0113	porphobilinogen synthase activity
I3J19_RS11345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J19_RS11350	COG0596	Alpha beta hydrolase
I3J19_RS11375	COG1136	(ABC) transporter
I3J19_RS11450	COG1725	Transcriptional regulator
I3J19_RS11470	COG1309	transcriptional regulator
I3J19_RS11490	COG0702	epimerase
I3J19_RS11500	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS11525	COG0259	pyridoxamine-phosphate oxidase activity
I3J19_RS11540	COG2072	flavoprotein involved in K transport
I3J19_RS11550	COG1024	Enoyl-CoA hydratase
I3J19_RS11560	COG0456	acetyltransferase
I3J19_RS11565	COG2814	Major facilitator Superfamily
I3J19_RS11565	COG0477	Major facilitator Superfamily
I3J19_RS11570	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J19_RS11585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J19_RS11590	COG2271	Major facilitator Superfamily
I3J19_RS11595	COG1917	Cupin 2, conserved barrel domain protein
I3J19_RS11595	COG4977	sequence-specific DNA binding
I3J19_RS11605	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS11625	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS11630	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS11640	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS11645	COG3397	chitin binding
I3J19_RS11715	COG0596	Alpha beta hydrolase
I3J19_RS11715	COG2945	thiolester hydrolase activity
I3J19_RS11725	COG4821	SIS domain
I3J19_RS11735	COG0259	pyridoxamine-phosphate oxidase activity
I3J19_RS11755	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS11770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J19_RS11835	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS11880	COG0726	polysaccharide deacetylase
I3J19_RS11910	COG0577	efflux transmembrane transporter activity
I3J19_RS11915	COG0577	efflux transmembrane transporter activity
I3J19_RS11915	COG1136	(ABC) transporter
I3J19_RS11950	COG0583	DNA-binding transcription factor activity
I3J19_RS11965	COG2205	protein histidine kinase activity
I3J19_RS11970	COG0745	RESPONSE REGULATOR receiver
I3J19_RS11985	COG0247	lactate metabolic process
I3J19_RS11985	COG0277	FAD linked oxidase domain protein
I3J19_RS11995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J19_RS12035	COG0463	Glycosyl transferase, family 2
I3J19_RS12045	COG3903	Transcriptional regulator
I3J19_RS12045	COG3629	intracellular signal transduction
I3J19_RS12060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J19_RS12100	COG1122	ATPase activity
I3J19_RS12120	COG0667	Aldo Keto reductase
I3J19_RS12155	COG2252	PERMEase
I3J19_RS12165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J19_RS12185	COG2814	Major facilitator Superfamily
I3J19_RS12195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J19_RS12200	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J19_RS12205	COG1278	Cold shock
I3J19_RS12240	COG1061	Type III restriction enzyme res subunit
I3J19_RS12250	COG3973	AAA domain
I3J19_RS12265	COG1595	DNA-templated transcription, initiation
I3J19_RS12340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J19_RS12345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J19_RS12355	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS12360	COG1605	Chorismate mutase
I3J19_RS12380	COG2197	response regulator
I3J19_RS12400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J19_RS12425	COG0191	fructose-bisphosphate aldolase activity
I3J19_RS12430	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J19_RS12445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J19_RS12450	COG2182	Extracellular solute-binding protein
I3J19_RS12475	COG0463	Glycosyl transferase, family 2
I3J19_RS12540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J19_RS12555	COG3842	ATPase activity
I3J19_RS12565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J19_RS12575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J19_RS12580	COG0215	cysteine-tRNA ligase activity
I3J19_RS12590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J19_RS12595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J19_RS12600	COG1329	Transcriptional regulator
I3J19_RS12615	COG5002	protein histidine kinase activity
I3J19_RS12630	COG0588	phosphoglycerate mutase activity
I3J19_RS12635	COG2211	Major facilitator Superfamily
I3J19_RS12660	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS12720	COG1490	D-aminoacyl-tRNA deacylase activity
I3J19_RS12735	COG3485	protocatechuate 3,4-dioxygenase
I3J19_RS12760	COG1309	transcriptional regulator
I3J19_RS12780	COG0745	RESPONSE REGULATOR receiver
I3J19_RS12785	COG1609	Transcriptional regulator
I3J19_RS12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J19_RS12815	COG2188	Transcriptional regulator
I3J19_RS12825	COG0737	Belongs to the 5'-nucleotidase family
I3J19_RS12825	COG1525	nuclease
I3J19_RS12825	COG4085	toxin activity
I3J19_RS12845	COG0456	acetyltransferase
I3J19_RS12850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J19_RS12860	COG0494	nUDIX hydrolase
I3J19_RS12860	COG0406	alpha-ribazole phosphatase activity
I3J19_RS12885	COG0306	phosphate transporter
I3J19_RS12895	COG1937	Protein conserved in bacteria
I3J19_RS12915	COG0671	phosphoesterase, PA-phosphatase related
I3J19_RS12920	COG1196	nuclear chromosome segregation
I3J19_RS12920	COG0741	lytic transglycosylase activity
I3J19_RS12920	COG0739	heme binding
I3J19_RS13015	COG0579	oxidoreductase
I3J19_RS13020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J19_RS13030	COG0741	lytic transglycosylase activity
I3J19_RS13030	COG1196	nuclear chromosome segregation
I3J19_RS13030	COG0739	heme binding
I3J19_RS13085	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J19_RS13095	COG0513	Belongs to the DEAD box helicase family
I3J19_RS13105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J19_RS13110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J19_RS13145	COG0785	Cytochrome C biogenesis protein
I3J19_RS13150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J19_RS13150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J19_RS13160	COG1643	Atp-dependent helicase
I3J19_RS13195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J19_RS13225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J19_RS13230	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J19_RS13235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J19_RS13270	COG2197	response regulator
I3J19_RS13280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J19_RS13295	COG0151	Belongs to the GarS family
I3J19_RS13320	COG0017	Asparaginyl-tRNA synthetase
I3J19_RS13325	COG1051	belongs to the nudix hydrolase family
I3J19_RS13335	COG0105	UTP biosynthetic process
I3J19_RS13375	COG2826	transposase and inactivated derivatives, IS30 family
I3J19_RS13405	COG3629	intracellular signal transduction
I3J19_RS13405	COG3903	Transcriptional regulator
I3J19_RS13470	COG0477	Major facilitator Superfamily
I3J19_RS13500	COG2234	aminopeptidase activity
I3J19_RS13505	COG0433	COG0433 Predicted ATPase
I3J19_RS13520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J19_RS13565	COG1191	sigma factor activity
I3J19_RS13570	COG1191	sigma factor activity
I3J19_RS13620	COG2304	oxidoreductase activity
I3J19_RS13625	COG2205	protein histidine kinase activity
I3J19_RS13630	COG0745	RESPONSE REGULATOR receiver
I3J19_RS13635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J19_RS13655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J19_RS13680	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS13690	COG1362	aminopeptidase activity
I3J19_RS13710	COG2271	Major facilitator Superfamily
I3J19_RS13725	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J19_RS13730	COG0022	dehydrogenase e1 component
I3J19_RS13755	COG0515	serine threonine protein kinase
I3J19_RS13760	COG0515	serine threonine protein kinase
I3J19_RS13775	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J19_RS13775	COG1136	(ABC) transporter
I3J19_RS13805	COG0303	'Molybdopterin
I3J19_RS13830	COG1522	sequence-specific DNA binding
I3J19_RS13835	COG1309	transcriptional regulator
I3J19_RS13840	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J19_RS13865	COG3396	Phenylacetate-CoA oxygenase
I3J19_RS13870	COG3460	Phenylacetate-CoA oxygenase
I3J19_RS13875	COG3396	Phenylacetate-CoA oxygenase
I3J19_RS13880	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J19_RS13885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J19_RS13890	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS13895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J19_RS13910	COG2197	response regulator
I3J19_RS13915	COG4585	Histidine kinase
I3J19_RS13940	COG1136	(ABC) transporter
I3J19_RS13940	COG0577	efflux transmembrane transporter activity
I3J19_RS13945	COG0577	efflux transmembrane transporter activity
I3J19_RS13945	COG1136	(ABC) transporter
I3J19_RS13955	COG1716	ATPase activity
I3J19_RS13960	COG1716	ATPase activity
I3J19_RS13975	COG0768	penicillin binding
I3J19_RS13980	COG0515	serine threonine protein kinase
I3J19_RS13985	COG3764	Sortase (surface protein transpeptidase)
I3J19_RS13990	COG3764	Sortase (surface protein transpeptidase)
I3J19_RS14005	COG3764	Sortase (surface protein transpeptidase)
I3J19_RS14020	COG0457	Tetratricopeptide repeat
I3J19_RS14020	COG0705	Rhomboid family
I3J19_RS14050	COG1446	asparaginase
I3J19_RS14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J19_RS14060	COG1280	lysine exporter protein (LysE YggA)
I3J19_RS14065	COG1672	PFAM Archaeal ATPase
I3J19_RS14065	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J19_RS14080	COG0667	Aldo Keto reductase
I3J19_RS14085	COG2175	clavaminate synthase activity
I3J19_RS14090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J19_RS14095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS14100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS14115	COG0515	serine threonine protein kinase
I3J19_RS14135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J19_RS14145	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J19_RS14150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J19_RS14155	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J19_RS14160	COG0592	DNA-directed DNA polymerase activity
I3J19_RS14170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J19_RS14175	COG0594	ribonuclease P activity
I3J19_RS14180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J19_RS14185	COG0706	membrane insertase activity
I3J19_RS14195	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J19_RS14200	COG1192	Involved in chromosome partitioning
I3J19_RS14215	COG3118	belongs to the thioredoxin family
I3J19_RS14220	COG0492	ferredoxin-NADP+ reductase activity
I3J19_RS14230	COG1595	DNA-templated transcription, initiation
I3J19_RS14235	COG0515	serine threonine protein kinase
I3J19_RS14235	COG2815	serine threonine protein kinase
I3J19_RS14250	COG0617	tRNA 3'-terminal CCA addition
I3J19_RS14270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J19_RS14295	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J19_RS14300	COG0629	single-stranded DNA binding
I3J19_RS14305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J19_RS14310	COG0359	binds to the 23S rRNA
I3J19_RS14320	COG0305	Participates in initiation and elongation during chromosome replication
I3J19_RS14355	COG0626	cystathionine gamma-synthase activity
I3J19_RS14360	COG1950	PFAM Membrane protein of
I3J19_RS14365	COG0662	Cupin 2, conserved barrel domain protein
I3J19_RS14385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J19_RS14400	COG1609	Transcriptional regulator
I3J19_RS14405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J19_RS14410	COG1271	oxidase subunit
I3J19_RS14415	COG1294	oxidase, subunit
I3J19_RS14420	COG4988	ABC transporter
I3J19_RS14430	COG0561	phosphatase activity
I3J19_RS14440	COG1131	(ABC) transporter
I3J19_RS14475	COG0561	phosphatase activity
I3J19_RS14480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J19_RS14485	COG0077	Prephenate dehydratase
I3J19_RS14490	COG2837	iron assimilation
I3J19_RS14505	COG1999	signal sequence binding
I3J19_RS14525	COG0006	proline dipeptidase activity
I3J19_RS14555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J19_RS14585	COG0587	DNA-directed DNA polymerase activity
I3J19_RS14590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J19_RS14615	COG1595	DNA-templated transcription, initiation
I3J19_RS14620	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS14625	COG0784	Response regulator, receiver
I3J19_RS14655	COG0745	RESPONSE REGULATOR receiver
I3J19_RS14660	COG0477	Major facilitator Superfamily
I3J19_RS14680	COG0431	NADPH-dependent FMN reductase
I3J19_RS14705	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J19_RS14705	COG1672	PFAM Archaeal ATPase
I3J19_RS14710	COG0431	NADPH-dependent FMN reductase
I3J19_RS14740	COG0598	Magnesium transport protein CorA
I3J19_RS14745	COG3345	alpha-galactosidase
I3J19_RS14825	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J19_RS14835	COG2226	methyltransferase
I3J19_RS14840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J19_RS14880	COG2826	transposase and inactivated derivatives, IS30 family
I3J19_RS14985	COG1857	crispr-associated protein
I3J19_RS15005	COG0436	Aminotransferase
I3J19_RS15020	COG2197	response regulator
I3J19_RS15030	COG0577	efflux transmembrane transporter activity
I3J19_RS15090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J19_RS15115	COG3629	intracellular signal transduction
I3J19_RS15115	COG3903	Transcriptional regulator
I3J19_RS15165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J19_RS15175	COG0534	Mate efflux family protein
I3J19_RS15180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J19_RS15185	COG0019	diaminopimelate decarboxylase activity
I3J19_RS15200	COG4166	transmembrane transport
I3J19_RS15205	COG0601	transmembrane transport
I3J19_RS15210	COG4171	peptide transport system, permease
I3J19_RS15225	COG2197	response regulator
I3J19_RS15230	COG4585	Histidine kinase
I3J19_RS15235	COG2409	Drug exporters of the RND superfamily
I3J19_RS15260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J19_RS15270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J19_RS15275	COG0588	phosphoglycerate mutase activity
I3J19_RS15325	COG0717	Belongs to the dCTP deaminase family
I3J19_RS15340	COG0247	lactate metabolic process
I3J19_RS15340	COG2181	nitrate reductase activity
I3J19_RS15345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J19_RS15350	COG0443	Heat shock 70 kDa protein
I3J19_RS15355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J19_RS15360	COG0484	heat shock protein binding
I3J19_RS15365	COG0789	Transcriptional regulator
I3J19_RS15385	COG0542	response to heat
I3J19_RS15415	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J19_RS15430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J19_RS15435	COG0191	fructose-bisphosphate aldolase activity
I3J19_RS15440	COG0477	Major facilitator Superfamily
I3J19_RS15475	COG4585	Histidine kinase
I3J19_RS15485	COG2124	cytochrome p450
I3J19_RS15515	COG0463	Glycosyl transferase, family 2
I3J19_RS15520	COG1802	Transcriptional regulator
I3J19_RS15535	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J19_RS15535	COG2319	Wd-40 repeat
I3J19_RS15540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS15575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J19_RS15590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J19_RS15595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J19_RS15610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J19_RS15615	COG1595	DNA-templated transcription, initiation
I3J19_RS15640	COG2124	cytochrome p450
I3J19_RS15655	COG2091	lysine biosynthetic process via aminoadipic acid
I3J19_RS15670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J19_RS15700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J19_RS15785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J19_RS15805	COG1408	metallophosphoesterase
I3J19_RS15810	COG1610	YqeY-like protein
I3J19_RS15815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J19_RS15825	COG0003	Pfam Anion-transporting ATPase
I3J19_RS15855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J19_RS15885	COG2267	carboxylic ester hydrolase activity
I3J19_RS15895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J19_RS15900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J19_RS15905	COG0659	secondary active sulfate transmembrane transporter activity
I3J19_RS15965	COG1205	dead DEAH box helicase
I3J19_RS15965	COG1111	helicase
I3J19_RS15970	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J19_RS15975	COG2172	sigma factor antagonist activity
I3J19_RS15980	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J19_RS15990	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J19_RS16000	COG1754	DNA topoisomerase type I activity
I3J19_RS16000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J19_RS16005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J19_RS16010	COG0470	DNA polymerase III
I3J19_RS16020	COG0477	Major facilitator Superfamily
I3J19_RS16060	COG1061	Type III restriction enzyme res subunit
I3J19_RS16105	COG0791	NLP P60 protein
I3J19_RS16185	COG0305	Participates in initiation and elongation during chromosome replication
I3J19_RS16345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J19_RS16455	COG1132	(ABC) transporter
I3J19_RS16460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J19_RS16460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J19_RS16465	COG0110	maltose O-acetyltransferase activity
I3J19_RS16505	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS16510	COG2318	DinB family
I3J19_RS16525	COG0076	glutamate decarboxylase activity
I3J19_RS16540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J19_RS16545	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J19_RS16555	COG0037	tRNA processing
I3J19_RS16570	COG0302	gtp cyclohydrolase
I3J19_RS16585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J19_RS16610	COG1174	glycine betaine transport
I3J19_RS16625	COG0649	NAD binding
I3J19_RS16640	COG2197	response regulator
I3J19_RS16655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J19_RS16660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J19_RS16670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J19_RS16690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J19_RS16705	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J19_RS16715	COG0739	heme binding
I3J19_RS16720	COG2205	protein histidine kinase activity
I3J19_RS16725	COG0745	RESPONSE REGULATOR receiver
I3J19_RS16735	COG1595	DNA-templated transcription, initiation
I3J19_RS16740	COG1194	a g-specific adenine glycosylase
I3J19_RS16745	COG0671	phosphoesterase, PA-phosphatase related
I3J19_RS16755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J19_RS16775	COG0248	Ppx GppA phosphatase
I3J19_RS16785	COG0129	dihydroxy-acid dehydratase activity
I3J19_RS16805	COG2226	methyltransferase
I3J19_RS16810	COG1595	DNA-templated transcription, initiation
I3J19_RS16815	COG1252	NADH dehydrogenase
I3J19_RS16820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J19_RS16825	COG0180	Tryptophanyl-tRNA synthetase
I3J19_RS16850	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J19_RS16885	COG1595	DNA-templated transcription, initiation
I3J19_RS16900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J19_RS16905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J19_RS16910	COG0181	hydroxymethylbilane synthase activity
I3J19_RS16915	COG1648	precorrin-2 dehydrogenase activity
I3J19_RS16915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J19_RS16940	COG1846	Transcriptional regulator
I3J19_RS16945	COG3384	dioxygenase
I3J19_RS16965	COG0477	Major facilitator Superfamily
I3J19_RS16975	COG3191	aminopeptidase activity
I3J19_RS16990	COG1970	mechanosensitive ion channel activity
I3J19_RS17000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J19_RS17025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J19_RS17030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J19_RS17040	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J19_RS17045	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J19_RS17045	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J19_RS17050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J19_RS17095	COG2072	flavoprotein involved in K transport
I3J19_RS17100	COG2267	carboxylic ester hydrolase activity
I3J19_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS17110	COG4946	Tricorn protease homolog
I3J19_RS17110	COG0793	Belongs to the peptidase S41A family
I3J19_RS17120	COG2409	Drug exporters of the RND superfamily
I3J19_RS17130	COG0310	cobalt ion transport
I3J19_RS17140	COG1122	ATPase activity
I3J19_RS17145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J19_RS17185	COG0124	histidyl-tRNA synthetase
I3J19_RS17210	COG3409	Peptidoglycan-binding domain 1 protein
I3J19_RS17215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J19_RS17235	COG0442	prolyl-tRNA aminoacylation
I3J19_RS17265	COG0084	hydrolase, TatD family'
I3J19_RS17275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J19_RS17280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J19_RS17305	COG0488	(ABC) transporter
I3J19_RS17335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J19_RS17340	COG2197	response regulator
I3J19_RS17350	COG4106	trans-aconitate 2-methyltransferase activity
I3J19_RS17355	COG1309	transcriptional regulator
I3J19_RS17365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J19_RS17375	COG0193	aminoacyl-tRNA hydrolase activity
I3J19_RS17380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J19_RS17385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J19_RS17390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J19_RS17400	COG4585	Histidine kinase
I3J19_RS17430	COG0477	Major facilitator Superfamily
I3J19_RS17445	COG1136	(ABC) transporter
I3J19_RS17450	COG0577	efflux transmembrane transporter activity
I3J19_RS17460	COG1595	DNA-templated transcription, initiation
I3J19_RS17485	COG2815	serine threonine protein kinase
I3J19_RS17485	COG0515	serine threonine protein kinase
I3J19_RS17515	COG1652	LysM domain
I3J19_RS17525	COG0148	phosphopyruvate hydratase activity
I3J19_RS17545	COG1252	NADH dehydrogenase
I3J19_RS17550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J19_RS17555	COG1136	(ABC) transporter
I3J19_RS17555	COG0577	efflux transmembrane transporter activity
I3J19_RS17560	COG1136	(ABC) transporter
I3J19_RS17560	COG0577	efflux transmembrane transporter activity
I3J19_RS17590	COG0183	Belongs to the thiolase family
I3J19_RS17595	COG2755	lipolytic protein G-D-S-L family
I3J19_RS17610	COG1737	Transcriptional regulator
I3J19_RS17670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J19_RS17700	COG1228	amidohydrolase
I3J19_RS17725	COG1191	sigma factor activity
I3J19_RS17750	COG3104	oligopeptide transport
I3J19_RS17755	COG0745	RESPONSE REGULATOR receiver
I3J19_RS17760	COG2205	protein histidine kinase activity
I3J19_RS17795	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J19_RS17880	COG1309	transcriptional regulator
I3J19_RS17885	COG0596	Alpha beta hydrolase
I3J19_RS17890	COG1316	TRANSCRIPTIONal
I3J19_RS17895	COG1607	acyl-coa hydrolase
I3J19_RS17900	COG1316	TRANSCRIPTIONal
I3J19_RS17920	COG1316	TRANSCRIPTIONal
I3J19_RS17945	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J19_RS17945	COG0778	Nitroreductase
I3J19_RS17950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J19_RS17985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J19_RS17990	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J19_RS18000	COG1482	cell wall glycoprotein biosynthetic process
I3J19_RS18010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J19_RS18035	COG2826	transposase and inactivated derivatives, IS30 family
I3J19_RS18045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J19_RS18050	COG0745	RESPONSE REGULATOR receiver
I3J19_RS18055	COG5002	protein histidine kinase activity
I3J19_RS18055	COG5000	phosphorelay sensor kinase activity
I3J19_RS18060	COG0823	Involved in the tonB-independent uptake of proteins
I3J19_RS18070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J19_RS18075	COG2197	response regulator
I3J19_RS18080	COG3214	Protein conserved in bacteria
I3J19_RS18090	COG0653	protein targeting
I3J19_RS18115	COG2902	Dehydrogenase
I3J19_RS18125	COG0395	ABC-type sugar transport system, permease component
I3J19_RS18130	COG1175	transmembrane transport
I3J19_RS18145	COG0515	serine threonine protein kinase
I3J19_RS18150	COG0515	serine threonine protein kinase
I3J19_RS18155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J19_RS18165	COG2884	Cell division ATP-binding protein ftsE
I3J19_RS18175	COG0793	Belongs to the peptidase S41A family
I3J19_RS18180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J19_RS18195	COG0583	DNA-binding transcription factor activity
I3J19_RS18220	COG3973	AAA domain
I3J19_RS18230	COG0776	regulation of translation
I3J19_RS18235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J19_RS18240	COG1678	Uncharacterized ACR, COG1678
I3J19_RS18255	COG1175	transmembrane transport
I3J19_RS18260	COG0395	ABC-type sugar transport system, permease component
I3J19_RS18265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J19_RS18305	COG3654	unkown
I3J19_RS18330	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J19_RS18335	COG0745	RESPONSE REGULATOR receiver
I3J19_RS18340	COG5002	protein histidine kinase activity
I3J19_RS18360	COG0277	FAD linked oxidase domain protein
I3J19_RS18400	COG1335	isochorismatase
I3J19_RS18410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J19_RS18420	COG1113	amino acid transport
I3J19_RS18430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J19_RS18435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS18440	COG1120	ATPase activity
I3J19_RS18455	COG1234	tRNA 3'-trailer cleavage
I3J19_RS18460	COG1263	PTS System
I3J19_RS18465	COG1263	PTS System
I3J19_RS18470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J19_RS18475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J19_RS18485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J19_RS18515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J19_RS18525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J19_RS18540	COG1131	(ABC) transporter
I3J19_RS18550	COG2733	membrane
I3J19_RS18580	COG0706	membrane insertase activity
I3J19_RS18590	COG0673	inositol 2-dehydrogenase activity
I3J19_RS18660	COG1126	abc transporter atp-binding protein
I3J19_RS18665	COG0765	amino acid transport
I3J19_RS18670	COG0765	amino acid transport
I3J19_RS18680	COG0154	amidase activity
I3J19_RS18690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS18725	COG0406	alpha-ribazole phosphatase activity
I3J19_RS18765	COG0745	RESPONSE REGULATOR receiver
I3J19_RS18780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J19_RS18785	COG4977	sequence-specific DNA binding
I3J19_RS18795	COG0589	response to stress
I3J19_RS18800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J19_RS18825	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J19_RS18830	COG0076	glutamate decarboxylase activity
I3J19_RS18840	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS18855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J19_RS18860	COG1309	transcriptional regulator
I3J19_RS18870	COG2124	cytochrome p450
I3J19_RS18875	COG1946	Acyl-CoA thioesterase
I3J19_RS18890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J19_RS18900	COG3960	tartronate-semialdehyde synthase activity
I3J19_RS18920	COG1674	ftsk spoiiie
I3J19_RS18985	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J19_RS19000	COG1609	Transcriptional regulator
I3J19_RS19005	COG0673	inositol 2-dehydrogenase activity
I3J19_RS19020	COG1595	DNA-templated transcription, initiation
I3J19_RS19030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J19_RS19055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J19_RS19065	COG3718	enzyme involved in inositol metabolism
I3J19_RS19070	COG3962	Belongs to the TPP enzyme family
I3J19_RS19090	COG1131	(ABC) transporter
I3J19_RS19150	COG0105	UTP biosynthetic process
I3J19_RS19155	COG2197	response regulator
I3J19_RS19165	COG2954	triphosphatase activity
I3J19_RS19175	COG0494	nUDIX hydrolase
I3J19_RS19205	COG0561	phosphatase activity
I3J19_RS19215	COG0475	glutathione-regulated potassium exporter activity
I3J19_RS19245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J19_RS19255	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J19_RS19260	COG1518	maintenance of DNA repeat elements
I3J19_RS19270	COG1203	CRISPR-associated helicase, Cas3
I3J19_RS19310	COG0629	single-stranded DNA binding
I3J19_RS19340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J19_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J19_RS19400	COG1486	melibiose metabolic process
I3J19_RS19405	COG0395	ABC-type sugar transport system, permease component
I3J19_RS19410	COG1175	transmembrane transport
I3J19_RS19430	COG0668	transmembrane transport
I3J19_RS19500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J19_RS19505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J19_RS19515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J19_RS19525	COG0588	phosphoglycerate mutase activity
I3J19_RS19530	COG1113	amino acid transport
I3J19_RS19540	COG1113	amino acid transport
I3J19_RS19555	COG4552	Acetyltransferase involved in intracellular survival and related
I3J19_RS19570	COG0475	glutathione-regulated potassium exporter activity
I3J19_RS19585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J19_RS19590	COG3594	Acyltransferase
I3J19_RS19610	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J19_RS19615	COG0740	serine-type endopeptidase activity
I3J19_RS19620	COG0740	serine-type endopeptidase activity
I3J19_RS19625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J19_RS19635	COG0525	valine-tRNA ligase activity
I3J19_RS19640	COG4585	Histidine kinase
I3J19_RS19645	COG0285	dihydrofolate synthase activity
I3J19_RS19655	COG0105	UTP biosynthetic process
I3J19_RS19660	COG1077	Cell shape determining protein MreB Mrl
I3J19_RS19680	COG0772	Belongs to the SEDS family
I3J19_RS19700	COG1530	ribonuclease E activity
I3J19_RS19710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J19_RS19715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J19_RS19720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J19_RS19725	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS19740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J19_RS19750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J19_RS19765	COG0501	Belongs to the peptidase M48B family
I3J19_RS19775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J19_RS19785	COG0799	negative regulation of ribosome biogenesis
I3J19_RS19790	COG0588	phosphoglycerate mutase activity
I3J19_RS19800	COG0495	leucyl-tRNA aminoacylation
I3J19_RS19810	COG1307	EDD domain protein, DegV family
I3J19_RS19845	COG0268	Binds directly to 16S ribosomal RNA
I3J19_RS19850	COG0481	GTPase activity
I3J19_RS19875	COG1420	regulation of RNA biosynthetic process
I3J19_RS19880	COG0484	heat shock protein binding
I3J19_RS19900	COG0793	Belongs to the peptidase S41A family
I3J19_RS19900	COG4946	Tricorn protease homolog
I3J19_RS19905	COG0537	adenosine 5'-monophosphoramidase activity
I3J19_RS19910	COG1234	tRNA 3'-trailer cleavage
I3J19_RS19915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J19_RS19920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J19_RS19930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J19_RS19970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J19_RS19985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J19_RS20000	COG1381	Involved in DNA repair and RecF pathway recombination
I3J19_RS20005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J19_RS20015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J19_RS20020	COG3842	ATPase activity
I3J19_RS20025	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J19_RS20025	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J19_RS20030	COG0423	glycine-tRNA ligase activity
I3J19_RS20070	COG0574	Belongs to the PEP-utilizing enzyme family
I3J19_RS20070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J19_RS20085	COG0531	amino acid
I3J19_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS20100	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J19_RS20120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J19_RS20140	COG2949	membrane
I3J19_RS20145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J19_RS20155	COG0358	DNA primase activity
I3J19_RS20160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J19_RS20175	COG1070	Carbohydrate kinase
I3J19_RS20210	COG0842	Transport permease protein
I3J19_RS20210	COG1129	ABC transporter
I3J19_RS20270	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS20280	COG1136	(ABC) transporter
I3J19_RS20335	COG2130	NADP-dependent
I3J19_RS20370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J19_RS20375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J19_RS20380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J19_RS20405	COG0789	Transcriptional regulator
I3J19_RS20410	COG0667	Aldo Keto reductase
I3J19_RS20415	COG2197	response regulator
I3J19_RS20420	COG4585	Histidine kinase
I3J19_RS20440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J19_RS20445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J19_RS20490	COG1358	cellular component organization or biogenesis
I3J19_RS20500	COG0586	Pfam SNARE associated Golgi protein
I3J19_RS20525	COG0582	viral genome integration into host DNA
I3J19_RS20635	COG4122	O-methyltransferase activity
I3J19_RS20645	COG2124	cytochrome p450
I3J19_RS20650	COG0183	Belongs to the thiolase family
I3J19_RS20665	COG3845	ABC transporter
I3J19_RS20700	COG1309	transcriptional regulator
I3J19_RS20705	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS20710	COG2226	methyltransferase
I3J19_RS20720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS20740	COG0183	Belongs to the thiolase family
I3J19_RS20755	COG2030	dehydratase
I3J19_RS20760	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J19_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS20780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J19_RS20800	COG0800	Aldolase
I3J19_RS20805	COG3022	response to hydroperoxide
I3J19_RS20820	COG0789	Transcriptional regulator
I3J19_RS20840	COG1349	DNA-binding transcription factor activity
I3J19_RS20845	COG1653	transport
I3J19_RS20855	COG0395	ABC-type sugar transport system, permease component
I3J19_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS20905	COG3540	Alkaline phosphatase
I3J19_RS20910	COG2814	Major facilitator Superfamily
I3J19_RS20925	COG1834	amidinotransferase
I3J19_RS20945	COG1120	ATPase activity
I3J19_RS20950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS20975	COG5398	heme oxygenase
I3J19_RS21010	COG1994	Peptidase M50
I3J19_RS21030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J19_RS21040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J19_RS21040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J19_RS21045	COG2132	Multicopper oxidase
I3J19_RS21080	COG0174	glutamine synthetase
I3J19_RS21095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J19_RS21110	COG1228	amidohydrolase
I3J19_RS21135	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J19_RS21140	COG0494	nUDIX hydrolase
I3J19_RS21155	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J19_RS21175	COG1609	Transcriptional regulator
I3J19_RS21180	COG0366	Alpha amylase catalytic
I3J19_RS21185	COG3833	ABC-type maltose transport systems, permease component
I3J19_RS21190	COG1175	transmembrane transport
I3J19_RS21220	COG2197	response regulator
I3J19_RS21260	COG0745	RESPONSE REGULATOR receiver
I3J19_RS21270	COG0673	inositol 2-dehydrogenase activity
I3J19_RS21295	COG0181	hydroxymethylbilane synthase activity
I3J19_RS21345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J19_RS21350	COG0321	lipoyl(octanoyl) transferase activity
I3J19_RS21365	COG1090	epimerase
I3J19_RS21395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J19_RS21405	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J19_RS21410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J19_RS21415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J19_RS21420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J19_RS21430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J19_RS21460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J19_RS21465	COG1132	(ABC) transporter
I3J19_RS21490	COG4585	Histidine kinase
I3J19_RS21495	COG2197	response regulator
I3J19_RS21500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J19_RS21510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J19_RS21530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J19_RS21540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J19_RS21545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J19_RS21555	COG1376	ErfK ybiS ycfS ynhG family protein
I3J19_RS21565	COG1845	cytochrome c oxidase, subunit III
I3J19_RS21570	COG2010	Cytochrome c
I3J19_RS21575	COG0723	plastoquinol--plastocyanin reductase activity
I3J19_RS21580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J19_RS21585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J19_RS21590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J19_RS21595	COG1929	Belongs to the glycerate kinase type-1 family
I3J19_RS21605	COG0745	RESPONSE REGULATOR receiver
I3J19_RS21610	COG2205	protein histidine kinase activity
I3J19_RS21660	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS21685	COG0003	Pfam Anion-transporting ATPase
I3J19_RS21695	COG1940	carbohydrate kinase activity
I3J19_RS21725	COG2197	response regulator
I3J19_RS21730	COG0205	6-phosphofructokinase activity
I3J19_RS21740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J19_RS21745	COG0243	molybdopterin cofactor binding
I3J19_RS21750	COG2193	ferroxidase activity
I3J19_RS21755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J19_RS21760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J19_RS21765	COG2815	serine threonine protein kinase
I3J19_RS21765	COG0515	serine threonine protein kinase
I3J19_RS21770	COG2022	thiamine diphosphate biosynthetic process
I3J19_RS21780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J19_RS21780	COG2022	thiamine diphosphate biosynthetic process
I3J19_RS21800	COG0352	thiamine-phosphate diphosphorylase activity
I3J19_RS21815	COG1233	COG1233 Phytoene dehydrogenase and related
I3J19_RS21825	COG1309	transcriptional regulator
I3J19_RS21830	COG1511	domain protein
I3J19_RS21835	COG1121	(ABC) transporter
I3J19_RS21865	COG0714	Associated with various cellular activities
I3J19_RS21875	COG0275	rRNA processing
I3J19_RS21885	COG0768	penicillin binding
I3J19_RS21890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J19_RS21895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J19_RS21900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J19_RS21905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J19_RS21915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J19_RS21920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J19_RS21930	COG1496	oxidoreductase activity
I3J19_RS21940	COG1799	cell septum assembly
I3J19_RS21950	COG3599	regulation of cell shape
I3J19_RS21955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J19_RS21970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J19_RS22020	COG0587	DNA-directed DNA polymerase activity
I3J19_RS22030	COG1432	Conserved Protein
I3J19_RS22050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J19_RS22070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J19_RS22075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J19_RS22080	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J19_RS22090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J19_RS22095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J19_RS22100	COG0251	oxidation-reduction process
I3J19_RS22105	COG0107	imidazoleglycerol-phosphate synthase activity
I3J19_RS22120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J19_RS22125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J19_RS22145	COG0134	indole-3-glycerol-phosphate synthase activity
I3J19_RS22155	COG0133	tryptophan synthase activity
I3J19_RS22160	COG0159	tryptophan synthase activity
I3J19_RS22170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J19_RS22175	COG2301	Belongs to the HpcH HpaI aldolase family
I3J19_RS22180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J19_RS22185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J19_RS22220	COG0070	glutamate synthase
I3J19_RS22220	COG0067	glutamate synthase
I3J19_RS22220	COG0069	glutamate synthase activity
I3J19_RS22245	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS22255	COG1309	transcriptional regulator
I3J19_RS22260	COG0183	Belongs to the thiolase family
I3J19_RS22290	COG1024	Enoyl-CoA hydratase
I3J19_RS22300	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS22315	COG1470	cell adhesion involved in biofilm formation
I3J19_RS22315	COG0366	Alpha amylase catalytic
I3J19_RS22330	COG1605	Chorismate mutase
I3J19_RS22330	COG0287	Prephenate dehydrogenase
I3J19_RS22380	COG0411	ABC transporter
I3J19_RS22400	COG2050	protein possibly involved in aromatic compounds catabolism
I3J19_RS22430	COG1643	Atp-dependent helicase
I3J19_RS22435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J19_RS22435	COG0596	Alpha beta hydrolase
I3J19_RS22435	COG2226	methyltransferase
I3J19_RS22440	COG0539	negative regulation of cytoplasmic translation
I3J19_RS22450	COG0237	dephospho-CoA kinase activity
I3J19_RS22470	COG0330	HflC and HflK could
I3J19_RS22475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J19_RS22505	COG2313	pseudouridylate synthase activity
I3J19_RS22515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J19_RS22520	COG0584	glycerophosphoryl diester phosphodiesterase
I3J19_RS22530	COG0556	nucleotide-excision repair
I3J19_RS22550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J19_RS22560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J19_RS22565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J19_RS22565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J19_RS22590	COG0322	excinuclease ABC activity
I3J19_RS22595	COG1660	Displays ATPase and GTPase activities
I3J19_RS22600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J19_RS22605	COG1481	regulation of sporulation
I3J19_RS22615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J19_RS22620	COG0126	phosphoglycerate kinase activity
I3J19_RS22625	COG0149	triose-phosphate isomerase activity
I3J19_RS22630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J19_RS22640	COG0166	Belongs to the GPI family
I3J19_RS22645	COG3402	PFAM membrane-flanked domain
I3J19_RS22655	COG0363	glucosamine-6-phosphate deaminase activity
I3J19_RS22670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J19_RS22680	COG0109	protoheme IX farnesyltransferase activity
I3J19_RS22710	COG1131	(ABC) transporter
I3J19_RS22725	COG0719	Fe-S assembly protein
I3J19_RS22735	COG0396	ATPase activity
I3J19_RS22740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J19_RS22745	COG0822	iron-sulfur transferase activity
I3J19_RS22750	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J19_RS22755	COG2171	N-acyltransferase activity
I3J19_RS22765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J19_RS22815	COG2205	protein histidine kinase activity
I3J19_RS22820	COG0745	RESPONSE REGULATOR receiver
I3J19_RS22835	COG1802	Transcriptional regulator
I3J19_RS22850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J19_RS22855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J19_RS22865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J19_RS22875	COG0768	penicillin binding
I3J19_RS22880	COG2197	response regulator
I3J19_RS22885	COG4585	Histidine kinase
I3J19_RS22890	COG1414	Transcriptional regulator
I3J19_RS22915	COG1902	pentaerythritol trinitrate reductase activity
I3J19_RS22920	COG5285	phytanoyl-CoA dioxygenase
I3J19_RS22925	COG1917	Cupin 2, conserved barrel domain protein
I3J19_RS22940	COG0134	indole-3-glycerol-phosphate synthase activity
I3J19_RS22970	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J19_RS22985	COG1492	cobalamin metabolic process
I3J19_RS22990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J19_RS23005	COG0235	Class ii aldolase
I3J19_RS23020	COG0488	(ABC) transporter
I3J19_RS23030	COG1024	Enoyl-CoA hydratase
I3J19_RS23070	COG3387	PFAM Glycoside hydrolase 15-related
I3J19_RS23105	COG1404	Belongs to the peptidase S8 family
I3J19_RS23115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J19_RS23120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J19_RS23140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J19_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS23160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J19_RS23165	COG2186	Transcriptional regulator
I3J19_RS23170	COG2807	transmembrane transport
I3J19_RS23185	COG0560	Phosphoserine phosphatase
I3J19_RS23185	COG3830	Belongs to the UPF0237 family
I3J19_RS23190	COG0842	Transport permease protein
I3J19_RS23190	COG1131	(ABC) transporter
I3J19_RS23190	COG1716	ATPase activity
I3J19_RS23200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J19_RS23210	COG4585	Histidine kinase
I3J19_RS23215	COG2197	response regulator
I3J19_RS23230	COG1119	ATPase activity
I3J19_RS23255	COG1881	PFAM PEBP family protein
I3J19_RS23265	COG2094	Belongs to the DNA glycosylase MPG family
I3J19_RS23300	COG0647	UMP catabolic process
I3J19_RS23305	COG1120	ATPase activity
I3J19_RS23325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J19_RS23330	COG0497	DNA recombination
I3J19_RS23335	COG0297	glycogen (starch) synthase activity
I3J19_RS23345	COG3387	PFAM Glycoside hydrolase 15-related
I3J19_RS23350	COG0504	CTP synthase activity
I3J19_RS23355	COG0494	nUDIX hydrolase
I3J19_RS23365	COG0686	Belongs to the AlaDH PNT family
I3J19_RS23380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J19_RS23385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J19_RS23390	COG1187	pseudouridine synthase activity
I3J19_RS23395	COG1056	cytidyltransferase-related domain
I3J19_RS23395	COG1051	belongs to the nudix hydrolase family
I3J19_RS23420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J19_RS23430	COG1160	GTP binding
I3J19_RS23450	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS23460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J19_RS23470	COG0671	phosphoesterase, PA-phosphatase related
I3J19_RS23475	COG0477	Major facilitator Superfamily
I3J19_RS23480	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS23485	COG1799	cell septum assembly
I3J19_RS23535	COG0641	radical SAM
I3J19_RS23550	COG3629	intracellular signal transduction
I3J19_RS23550	COG3903	Transcriptional regulator
I3J19_RS23555	COG0596	Alpha beta hydrolase
I3J19_RS23580	COG4565	transcriptional regulatory protein
I3J19_RS23605	COG1725	Transcriptional regulator
I3J19_RS23615	COG2755	lipolytic protein G-D-S-L family
I3J19_RS23625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J19_RS23630	COG2188	Transcriptional regulator
I3J19_RS23635	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J19_RS23640	COG2851	Citrate transporter
I3J19_RS23675	COG3876	Protein conserved in bacteria
I3J19_RS23690	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS23705	COG2149	membrane
I3J19_RS23725	COG3265	gluconokinase activity
I3J19_RS23730	COG2186	Transcriptional regulator
I3J19_RS23735	COG1113	amino acid transport
I3J19_RS23765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J19_RS23795	COG0667	Aldo Keto reductase
I3J19_RS23800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS23810	COG0598	Magnesium transport protein CorA
I3J19_RS23830	COG0215	cysteine-tRNA ligase activity
I3J19_RS23840	COG4948	Mandelate Racemase Muconate Lactonizing
I3J19_RS23845	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS23855	COG1129	ABC transporter
I3J19_RS23865	COG2186	Transcriptional regulator
I3J19_RS23870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J19_RS23875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J19_RS23880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J19_RS23885	COG1414	Transcriptional regulator
I3J19_RS23890	COG1410	methionine synthase
I3J19_RS23890	COG0646	methionine synthase
I3J19_RS23895	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS23910	COG2197	response regulator
I3J19_RS23920	COG0517	IMP dehydrogenase activity
I3J19_RS23920	COG1994	Peptidase M50
I3J19_RS23940	COG1222	aaa ATPase
I3J19_RS23945	COG4122	O-methyltransferase activity
I3J19_RS23960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J19_RS23965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J19_RS23970	COG1609	Transcriptional regulator
I3J19_RS23980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J19_RS24015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J19_RS24020	COG0805	protein transport
I3J19_RS24055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J19_RS24060	COG4175	Glycine betaine
I3J19_RS24060	COG0517	IMP dehydrogenase activity
I3J19_RS24080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J19_RS24085	COG1113	amino acid transport
I3J19_RS24090	COG2186	Transcriptional regulator
I3J19_RS24095	COG0174	glutamine synthetase
I3J19_RS24120	COG1404	Belongs to the peptidase S8 family
I3J19_RS24140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J19_RS24145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J19_RS24150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J19_RS24155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J19_RS24160	COG5002	protein histidine kinase activity
I3J19_RS24165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J19_RS24170	COG0072	phenylalanine-tRNA ligase activity
I3J19_RS24170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J19_RS24190	COG1649	PFAM Uncharacterised BCR, COG1649
I3J19_RS24200	COG0697	spore germination
I3J19_RS24210	COG2838	Isocitrate dehydrogenase
I3J19_RS24235	COG4585	Histidine kinase
I3J19_RS24240	COG2197	response regulator
I3J19_RS24245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J19_RS24250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J19_RS24255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J19_RS24260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J19_RS24265	COG1438	arginine binding
I3J19_RS24270	COG0137	argininosuccinate synthase activity
I3J19_RS24275	COG0165	Argininosuccinate lyase
I3J19_RS24285	COG0477	Major facilitator Superfamily
I3J19_RS24290	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS24290	COG0204	Acyl-transferase
I3J19_RS24295	COG0584	glycerophosphoryl diester phosphodiesterase
I3J19_RS24315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J19_RS24320	COG2011	ABC-type metal ion transport system permease component
I3J19_RS24325	COG1464	Belongs to the NlpA lipoprotein family
I3J19_RS24340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J19_RS24345	COG1648	precorrin-2 dehydrogenase activity
I3J19_RS24345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J19_RS24390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J19_RS24400	COG0456	acetyltransferase
I3J19_RS24450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J19_RS24455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J19_RS24460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J19_RS24480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J19_RS24485	COG1560	Kdo2-lipid A biosynthetic process
I3J19_RS24490	COG0438	transferase activity, transferring glycosyl groups
I3J19_RS24500	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J19_RS24505	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J19_RS24510	COG0217	transcriptional regulatory protein
I3J19_RS24515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J19_RS24520	COG0632	four-way junction helicase activity
I3J19_RS24525	COG2255	four-way junction helicase activity
I3J19_RS24535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J19_RS24540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J19_RS24545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J19_RS24550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J19_RS24560	COG1196	nuclear chromosome segregation
I3J19_RS24565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J19_RS24575	COG0124	histidyl-tRNA synthetase
I3J19_RS24595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J19_RS24610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J19_RS24615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J19_RS24620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J19_RS24625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J19_RS24630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J19_RS24635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J19_RS24640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J19_RS24645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J19_RS24655	COG0006	proline dipeptidase activity
I3J19_RS24660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J19_RS24665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J19_RS24675	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J19_RS24680	COG0540	Belongs to the ATCase OTCase family
I3J19_RS24685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J19_RS24695	COG0505	Belongs to the CarA family
I3J19_RS24700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J19_RS24705	COG0167	dihydroorotate dehydrogenase activity
I3J19_RS24710	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J19_RS24735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J19_RS24750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J19_RS24760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J19_RS24765	COG2390	Transcriptional regulator
I3J19_RS24795	COG1191	sigma factor activity
I3J19_RS24805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J19_RS24820	COG2233	PERMEase
I3J19_RS24830	COG0738	Major facilitator superfamily
I3J19_RS24835	COG1846	Transcriptional regulator
I3J19_RS24835	COG1940	carbohydrate kinase activity
I3J19_RS24850	COG3201	nicotinamide mononucleotide transporter
I3J19_RS24855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J19_RS24855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J19_RS24860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J19_RS24865	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J19_RS24870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J19_RS24910	COG1309	transcriptional regulator
I3J19_RS24915	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS24935	COG1216	Glycosyl transferase, family 2
I3J19_RS24950	COG2270	Major facilitator Superfamily
I3J19_RS24960	COG2364	Membrane
I3J19_RS24965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J19_RS24995	COG1984	allophanate hydrolase subunit 2
I3J19_RS25000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J19_RS25005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J19_RS25010	COG2814	Major facilitator Superfamily
I3J19_RS25040	COG5002	protein histidine kinase activity
I3J19_RS25045	COG2018	Roadblock/LC7 domain
I3J19_RS25060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J19_RS25065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J19_RS25070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J19_RS25090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J19_RS25100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J19_RS25130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J19_RS25150	COG1716	ATPase activity
I3J19_RS25170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J19_RS25180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J19_RS25180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J19_RS25245	COG0697	spore germination
I3J19_RS25300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J19_RS25315	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J19_RS25325	COG2813	Specifically methylates the guanine in position
I3J19_RS25340	COG1968	undecaprenyl-diphosphatase activity
I3J19_RS25355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J19_RS25380	COG2124	cytochrome p450
I3J19_RS25410	COG0110	maltose O-acetyltransferase activity
I3J19_RS25415	COG1832	CoA-binding protein
I3J19_RS25420	COG1739	Uncharacterized protein family UPF0029
I3J19_RS25430	COG0666	response to abiotic stimulus
I3J19_RS25435	COG0420	3'-5' exonuclease activity
I3J19_RS25440	COG0419	ATPase involved in DNA repair
I3J19_RS25440	COG0419	ATPase involved in DNA repair
I3J19_RS25445	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS25475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J19_RS25490	COG2188	Transcriptional regulator
I3J19_RS25495	COG1940	carbohydrate kinase activity
I3J19_RS25505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J19_RS25540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J19_RS25545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS25550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J19_RS25570	COG0740	serine-type endopeptidase activity
I3J19_RS25580	COG0831	urea catabolic process
I3J19_RS25585	COG0832	Belongs to the urease beta subunit family
I3J19_RS25590	COG0804	urea catabolic process
I3J19_RS25600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J19_RS25605	COG0829	nickel cation binding
I3J19_RS25615	COG0204	Acyl-transferase
I3J19_RS25630	COG0142	geranyltranstransferase activity
I3J19_RS25635	COG0142	geranyltranstransferase activity
I3J19_RS25655	COG0205	6-phosphofructokinase activity
I3J19_RS25660	COG3442	glutamine amidotransferase
I3J19_RS25670	COG0242	peptide deformylase activity
I3J19_RS25680	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS25705	COG0386	Belongs to the glutathione peroxidase family
I3J19_RS25710	COG1946	Acyl-CoA thioesterase
I3J19_RS25730	COG2375	cellular response to nickel ion
I3J19_RS25730	COG1132	(ABC) transporter
I3J19_RS25735	COG1132	(ABC) transporter
I3J19_RS25745	COG2409	Drug exporters of the RND superfamily
I3J19_RS25760	COG2124	cytochrome p450
I3J19_RS25770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J19_RS25780	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS25795	COG0477	Major facilitator Superfamily
I3J19_RS25825	COG4585	Histidine kinase
I3J19_RS25830	COG2197	response regulator
I3J19_RS25850	COG2409	Drug exporters of the RND superfamily
I3J19_RS25860	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J19_RS25860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J19_RS25865	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J19_RS25920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J19_RS25925	COG3321	synthase
I3J19_RS25925	COG0604	alcohol dehydrogenase
I3J19_RS25940	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS25960	COG1132	(ABC) transporter
I3J19_RS25965	COG2072	flavoprotein involved in K transport
I3J19_RS26025	COG0443	Heat shock 70 kDa protein
I3J19_RS26040	COG1309	transcriptional regulator
I3J19_RS26050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS26055	COG1902	pentaerythritol trinitrate reductase activity
I3J19_RS26110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J19_RS26155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS26160	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS26165	COG1120	ATPase activity
I3J19_RS26175	COG1132	(ABC) transporter
I3J19_RS26200	COG4607	ABC-type enterochelin transport system periplasmic component
I3J19_RS26205	COG0464	growth
I3J19_RS26210	COG1404	Belongs to the peptidase S8 family
I3J19_RS26215	COG1674	ftsk spoiiie
I3J19_RS26280	COG1278	Cold shock
I3J19_RS26295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J19_RS26305	COG0577	efflux transmembrane transporter activity
I3J19_RS26305	COG1136	(ABC) transporter
I3J19_RS26310	COG1136	(ABC) transporter
I3J19_RS26310	COG0577	efflux transmembrane transporter activity
I3J19_RS26325	COG0745	RESPONSE REGULATOR receiver
I3J19_RS26330	COG2205	protein histidine kinase activity
I3J19_RS26365	COG0463	Glycosyl transferase, family 2
I3J19_RS26370	COG0326	Molecular chaperone. Has ATPase activity
I3J19_RS26410	COG0309	Hydrogenase expression formation protein (HypE)
I3J19_RS26420	COG0298	carbon dioxide binding
I3J19_RS26430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J19_RS26435	COG0375	protein maturation
I3J19_RS26515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J19_RS26550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J19_RS26565	COG2706	6-phosphogluconolactonase activity
I3J19_RS26580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J19_RS26605	COG1309	transcriptional regulator
I3J19_RS26610	COG0671	phosphoesterase, PA-phosphatase related
I3J19_RS26635	COG0584	glycerophosphoryl diester phosphodiesterase
I3J19_RS26655	COG0204	Acyl-transferase
I3J19_RS26665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J19_RS26685	COG3345	alpha-galactosidase
I3J19_RS26695	COG1175	transmembrane transport
I3J19_RS26700	COG0395	ABC-type sugar transport system, permease component
I3J19_RS26720	COG0644	oxidoreductase
I3J19_RS26735	COG1940	carbohydrate kinase activity
I3J19_RS26755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J19_RS26765	COG1349	DNA-binding transcription factor activity
I3J19_RS26785	COG1215	transferase activity, transferring glycosyl groups
I3J19_RS26790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J19_RS26875	COG1486	melibiose metabolic process
I3J19_RS26920	COG1012	belongs to the aldehyde dehydrogenase family
I3J19_RS26925	COG0363	glucosamine-6-phosphate deaminase activity
I3J19_RS26950	COG1461	Dihydroxyacetone kinase
I3J19_RS26955	COG2376	Dihydroxyacetone kinase
I3J19_RS26990	COG1131	(ABC) transporter
I3J19_RS27045	COG1846	Transcriptional regulator
I3J19_RS27080	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J19_RS27085	COG1959	2 iron, 2 sulfur cluster binding
I3J19_RS27090	COG1017	nitric oxide dioxygenase activity
I3J19_RS27090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J19_RS27110	COG3511	phospholipase C
I3J19_RS27120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J19_RS27120	COG1796	DNA polymerase
I3J19_RS27130	COG2814	Major facilitator Superfamily
I3J19_RS27170	COG1960	acyl-CoA dehydrogenase activity
I3J19_RS27180	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J19_RS27195	COG1335	isochorismatase
I3J19_RS27200	COG0010	Belongs to the arginase family
I3J19_RS27205	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J19_RS27250	COG0701	Predicted permease
I3J19_RS27260	COG0515	serine threonine protein kinase
I3J19_RS27260	COG2815	serine threonine protein kinase
I3J19_RS27270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J19_RS27275	COG2070	2-Nitropropane dioxygenase
I3J19_RS27285	COG0387	Pfam Sodium calcium exchanger
I3J19_RS27290	COG2267	carboxylic ester hydrolase activity
I3J19_RS27295	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS27300	COG1024	Enoyl-CoA hydratase
I3J19_RS27360	COG2375	cellular response to nickel ion
I3J19_RS27360	COG1132	(ABC) transporter
I3J19_RS27375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J19_RS27375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J19_RS27385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J19_RS27390	COG0765	amino acid transport
I3J19_RS27395	COG1126	abc transporter atp-binding protein
I3J19_RS27415	COG1957	nucleoside hydrolase
I3J19_RS27425	COG2318	DinB family
I3J19_RS27445	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS27450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J19_RS27495	COG0501	Belongs to the peptidase M48B family
I3J19_RS27535	COG4412	M6 family metalloprotease domain protein
I3J19_RS27535	COG1404	Belongs to the peptidase S8 family
I3J19_RS27535	COG1404	Belongs to the peptidase S8 family
I3J19_RS27535	COG4412	M6 family metalloprotease domain protein
I3J19_RS27590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J19_RS27605	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS27640	COG0288	reversible hydration of carbon dioxide
I3J19_RS27650	COG0702	epimerase
I3J19_RS27660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J19_RS27675	COG2226	methyltransferase
I3J19_RS27685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J19_RS27690	COG1937	Protein conserved in bacteria
I3J19_RS27720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J19_RS27785	COG0142	geranyltranstransferase activity
I3J19_RS27795	COG1132	(ABC) transporter
I3J19_RS27805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J19_RS28000	COG3321	synthase
I3J19_RS28000	COG0604	alcohol dehydrogenase
I3J19_RS28015	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J19_RS28150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J19_RS28195	COG2161	toxin-antitoxin pair type II binding
I3J19_RS28240	COG3547	Transposase (IS116 IS110 IS902 family)
I3J19_RS28250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J19_RS28255	COG0318	PFAM AMP-dependent synthetase and ligase
I3J19_RS28325	COG2197	response regulator
I3J19_RS28355	COG2814	Major facilitator Superfamily
I3J19_RS28360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J19_RS28375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J19_RS28415	COG3321	synthase
I3J19_RS28415	COG0604	alcohol dehydrogenase
I3J19_RS28435	COG2814	Major facilitator Superfamily
I3J19_RS28455	COG0076	glutamate decarboxylase activity
I3J19_RS28490	COG0531	amino acid
I3J19_RS28500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J19_RS28515	COG2304	oxidoreductase activity
I3J19_RS28555	COG2197	response regulator
I3J19_RS28565	COG1222	aaa ATPase
I3J19_RS28575	COG3903	Transcriptional regulator
I3J19_RS28575	COG3629	intracellular signal transduction
I3J19_RS28650	COG2124	cytochrome p450
I3J19_RS28680	COG0789	Transcriptional regulator
I3J19_RS28685	COG0436	Aminotransferase
I3J19_RS28695	COG1695	Transcriptional regulator
I3J19_RS28700	COG2124	cytochrome p450
I3J19_RS28705	COG2124	cytochrome p450
I3J19_RS28710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J19_RS28715	COG0346	lactoylglutathione lyase activity
I3J19_RS28720	COG0640	Transcriptional regulator
I3J19_RS28730	COG2226	methyltransferase
I3J19_RS28740	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J19_RS28790	COG0577	efflux transmembrane transporter activity
I3J19_RS28790	COG1136	(ABC) transporter
I3J19_RS28795	COG0577	efflux transmembrane transporter activity
I3J19_RS28795	COG1136	(ABC) transporter
I3J19_RS28810	COG0745	RESPONSE REGULATOR receiver
I3J19_RS28815	COG2205	protein histidine kinase activity
I3J19_RS28845	COG4948	Mandelate Racemase Muconate Lactonizing
I3J19_RS28880	COG2124	cytochrome p450
I3J19_RS28890	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS29000	COG2124	cytochrome p450
I3J19_RS29025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J19_RS29060	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J19_RS29060	COG2319	Wd-40 repeat
I3J19_RS29065	COG1335	isochorismatase
I3J19_RS29105	COG3409	Peptidoglycan-binding domain 1 protein
I3J19_RS29110	COG3973	AAA domain
I3J19_RS29140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J19_RS29145	COG2133	pyrroloquinoline quinone binding
I3J19_RS29145	COG5183	chlorophyll binding
I3J19_RS29170	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS29180	COG2201	protein-glutamate methylesterase activity
I3J19_RS29195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS29200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J19_RS29205	COG0010	Belongs to the arginase family
I3J19_RS29210	COG0367	asparagine synthase
I3J19_RS29230	COG0436	Aminotransferase
I3J19_RS29235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J19_RS29245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J19_RS29260	COG0583	DNA-binding transcription factor activity
I3J19_RS29305	COG2111	Na H antiporter
I3J19_RS29305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J19_RS29310	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J19_RS29315	COG0651	ATP synthesis coupled electron transport
I3J19_RS29330	COG1320	monovalent cation:proton antiporter activity
I3J19_RS29485	COG3959	Transketolase, thiamine diphosphate binding domain
I3J19_RS29490	COG3958	Transketolase
I3J19_RS29525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J19_RS29530	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS29535	COG0277	FAD linked oxidase domain protein
I3J19_RS29540	COG1070	Carbohydrate kinase
I3J19_RS29585	COG2124	cytochrome p450
I3J19_RS29595	COG1011	Hydrolase
I3J19_RS29635	COG0789	Transcriptional regulator
I3J19_RS29645	COG3397	chitin binding
I3J19_RS29675	COG1132	(ABC) transporter
I3J19_RS29735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J19_RS29740	COG2124	cytochrome p450
I3J19_RS29755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J19_RS29775	COG3757	hydrolase, family 25
I3J19_RS29775	COG3409	Peptidoglycan-binding domain 1 protein
I3J19_RS29810	COG0488	(ABC) transporter
I3J19_RS29840	COG0698	ribose 5-phosphate isomerase
I3J19_RS29875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J19_RS29885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J19_RS29900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J19_RS29910	COG2267	carboxylic ester hydrolase activity
I3J19_RS29990	COG0477	Major facilitator Superfamily
I3J19_RS30035	COG1028	Short-chain dehydrogenase reductase Sdr
I3J19_RS30070	COG2226	methyltransferase
I3J19_RS30085	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J19_RS30100	COG3409	Peptidoglycan-binding domain 1 protein
I3J19_RS30140	COG0494	nUDIX hydrolase
I3J19_RS30155	COG3629	intracellular signal transduction
I3J19_RS30155	COG3903	Transcriptional regulator
I3J19_RS30180	COG1725	Transcriptional regulator
I3J19_RS30185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3J19_RS30195	COG1309	transcriptional regulator
I3J19_RS30220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J19_RS30270	COG2318	DinB family
I3J19_RS30365	COG2319	Wd-40 repeat
I3J19_RS30365	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J19_RS30395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J19_RS30400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J19_RS30415	COG0431	NADPH-dependent FMN reductase
I3J19_RS30425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS30430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS30435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J19_RS30470	COG0640	Transcriptional regulator
I3J19_RS30490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J19_RS30500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J19_RS30505	COG0301	tRNA thio-modification
I3J19_RS30535	COG1024	Enoyl-CoA hydratase
I3J19_RS30580	COG0110	maltose O-acetyltransferase activity
I3J19_RS30620	COG0477	Major facilitator Superfamily
I3J19_RS30660	COG0546	phosphoglycolate phosphatase activity
I3J19_RS30675	COG0363	glucosamine-6-phosphate deaminase activity
I3J19_RS30680	COG1940	carbohydrate kinase activity
I3J19_RS30705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J19_RS30715	COG4552	Acetyltransferase involved in intracellular survival and related
I3J19_RS30725	COG2816	NAD+ diphosphatase activity
I3J19_RS30735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J19_RS30740	COG1228	amidohydrolase
I3J19_RS30795	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J19_RS30800	COG1732	Glycine betaine
I3J19_RS30805	COG1174	glycine betaine transport
I3J19_RS30810	COG0517	IMP dehydrogenase activity
I3J19_RS30810	COG1125	glycine betaine transport
I3J19_RS30825	COG0076	glutamate decarboxylase activity
I3J19_RS30845	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J19_RS30850	COG1121	(ABC) transporter
I3J19_RS30895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs