locus-tag	class	description
I3J17_RS00275	COG1132	(ABC) transporter
I3J17_RS00350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J17_RS00380	COG1937	Protein conserved in bacteria
I3J17_RS00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J17_RS00395	COG2226	methyltransferase
I3J17_RS00410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J17_RS00420	COG0702	epimerase
I3J17_RS00430	COG0288	reversible hydration of carbon dioxide
I3J17_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS00480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J17_RS00535	COG1404	Belongs to the peptidase S8 family
I3J17_RS00535	COG4412	M6 family metalloprotease domain protein
I3J17_RS00535	COG1404	Belongs to the peptidase S8 family
I3J17_RS00535	COG4412	M6 family metalloprotease domain protein
I3J17_RS00575	COG0501	Belongs to the peptidase M48B family
I3J17_RS00620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS00625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS00645	COG2318	DinB family
I3J17_RS00655	COG1957	nucleoside hydrolase
I3J17_RS00675	COG1126	abc transporter atp-binding protein
I3J17_RS00680	COG0765	amino acid transport
I3J17_RS00685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J17_RS00695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J17_RS00695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J17_RS00710	COG2375	cellular response to nickel ion
I3J17_RS00710	COG1132	(ABC) transporter
I3J17_RS00775	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS00780	COG2267	carboxylic ester hydrolase activity
I3J17_RS00785	COG0387	Pfam Sodium calcium exchanger
I3J17_RS00795	COG2070	2-Nitropropane dioxygenase
I3J17_RS00800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J17_RS00810	COG0515	serine threonine protein kinase
I3J17_RS00810	COG2815	serine threonine protein kinase
I3J17_RS00820	COG0701	Predicted permease
I3J17_RS00865	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J17_RS00870	COG0010	Belongs to the arginase family
I3J17_RS00875	COG1335	isochorismatase
I3J17_RS00890	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3J17_RS00900	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS00940	COG2814	Major facilitator Superfamily
I3J17_RS00950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J17_RS00950	COG1796	DNA polymerase
I3J17_RS00960	COG3511	phospholipase C
I3J17_RS00980	COG1017	nitric oxide dioxygenase activity
I3J17_RS00980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J17_RS00985	COG1959	2 iron, 2 sulfur cluster binding
I3J17_RS00990	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J17_RS01025	COG1846	Transcriptional regulator
I3J17_RS01080	COG1131	(ABC) transporter
I3J17_RS01115	COG2376	Dihydroxyacetone kinase
I3J17_RS01120	COG1461	Dihydroxyacetone kinase
I3J17_RS01145	COG0363	glucosamine-6-phosphate deaminase activity
I3J17_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS01195	COG1486	melibiose metabolic process
I3J17_RS01280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I3J17_RS01285	COG1215	transferase activity, transferring glycosyl groups
I3J17_RS01305	COG1349	DNA-binding transcription factor activity
I3J17_RS01315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J17_RS01335	COG1940	carbohydrate kinase activity
I3J17_RS01350	COG0644	oxidoreductase
I3J17_RS01370	COG0395	ABC-type sugar transport system, permease component
I3J17_RS01375	COG1175	transmembrane transport
I3J17_RS01385	COG3345	alpha-galactosidase
I3J17_RS01405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J17_RS01415	COG0204	Acyl-transferase
I3J17_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
I3J17_RS01460	COG0671	phosphoesterase, PA-phosphatase related
I3J17_RS01465	COG1309	transcriptional regulator
I3J17_RS01490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J17_RS01505	COG2706	6-phosphogluconolactonase activity
I3J17_RS01520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J17_RS01555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J17_RS01635	COG0375	protein maturation
I3J17_RS01640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J17_RS01650	COG0298	carbon dioxide binding
I3J17_RS01660	COG0309	Hydrogenase expression formation protein (HypE)
I3J17_RS01700	COG0326	Molecular chaperone. Has ATPase activity
I3J17_RS01705	COG0463	Glycosyl transferase, family 2
I3J17_RS01740	COG2205	protein histidine kinase activity
I3J17_RS01745	COG0745	RESPONSE REGULATOR receiver
I3J17_RS01760	COG0577	efflux transmembrane transporter activity
I3J17_RS01760	COG1136	(ABC) transporter
I3J17_RS01765	COG0577	efflux transmembrane transporter activity
I3J17_RS01765	COG1136	(ABC) transporter
I3J17_RS01775	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J17_RS01790	COG1278	Cold shock
I3J17_RS01855	COG1674	ftsk spoiiie
I3J17_RS01860	COG1404	Belongs to the peptidase S8 family
I3J17_RS01865	COG0464	growth
I3J17_RS01870	COG4607	ABC-type enterochelin transport system periplasmic component
I3J17_RS01895	COG1132	(ABC) transporter
I3J17_RS01905	COG1120	ATPase activity
I3J17_RS01910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J17_RS02015	COG1902	pentaerythritol trinitrate reductase activity
I3J17_RS02020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS02030	COG1309	transcriptional regulator
I3J17_RS02045	COG0443	Heat shock 70 kDa protein
I3J17_RS02105	COG2072	flavoprotein involved in K transport
I3J17_RS02110	COG1132	(ABC) transporter
I3J17_RS02130	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS02145	COG3321	synthase
I3J17_RS02145	COG0604	alcohol dehydrogenase
I3J17_RS02150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J17_RS02205	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J17_RS02210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J17_RS02210	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J17_RS02220	COG2409	Drug exporters of the RND superfamily
I3J17_RS02240	COG2197	response regulator
I3J17_RS02245	COG4585	Histidine kinase
I3J17_RS02275	COG0477	Major facilitator Superfamily
I3J17_RS02290	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS02300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J17_RS02310	COG2124	cytochrome p450
I3J17_RS02325	COG2409	Drug exporters of the RND superfamily
I3J17_RS02335	COG1132	(ABC) transporter
I3J17_RS02340	COG1132	(ABC) transporter
I3J17_RS02340	COG2375	cellular response to nickel ion
I3J17_RS02360	COG1946	Acyl-CoA thioesterase
I3J17_RS02365	COG0386	Belongs to the glutathione peroxidase family
I3J17_RS02390	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS02400	COG0242	peptide deformylase activity
I3J17_RS02410	COG3442	glutamine amidotransferase
I3J17_RS02415	COG0205	6-phosphofructokinase activity
I3J17_RS02435	COG0142	geranyltranstransferase activity
I3J17_RS02440	COG0142	geranyltranstransferase activity
I3J17_RS02455	COG0204	Acyl-transferase
I3J17_RS02465	COG0829	nickel cation binding
I3J17_RS02470	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3J17_RS02480	COG0804	urea catabolic process
I3J17_RS02485	COG0832	Belongs to the urease beta subunit family
I3J17_RS02490	COG0831	urea catabolic process
I3J17_RS02500	COG0740	serine-type endopeptidase activity
I3J17_RS02520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3J17_RS02525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS02530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3J17_RS02565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J17_RS02575	COG1940	carbohydrate kinase activity
I3J17_RS02580	COG2188	Transcriptional regulator
I3J17_RS02595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J17_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS02630	COG0419	ATPase involved in DNA repair
I3J17_RS02630	COG0419	ATPase involved in DNA repair
I3J17_RS02635	COG0420	3'-5' exonuclease activity
I3J17_RS02640	COG0666	response to abiotic stimulus
I3J17_RS02650	COG1739	Uncharacterized protein family UPF0029
I3J17_RS02655	COG1832	CoA-binding protein
I3J17_RS02660	COG0110	maltose O-acetyltransferase activity
I3J17_RS02690	COG2124	cytochrome p450
I3J17_RS02715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J17_RS02725	COG1968	undecaprenyl-diphosphatase activity
I3J17_RS02740	COG2813	Specifically methylates the guanine in position
I3J17_RS02750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3J17_RS02765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I3J17_RS02820	COG0697	spore germination
I3J17_RS02885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J17_RS02885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3J17_RS02895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J17_RS02915	COG1716	ATPase activity
I3J17_RS02935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J17_RS02965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J17_RS02975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J17_RS02995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J17_RS03000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J17_RS03005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J17_RS03020	COG2018	Roadblock/LC7 domain
I3J17_RS03025	COG5002	protein histidine kinase activity
I3J17_RS03055	COG2814	Major facilitator Superfamily
I3J17_RS03060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I3J17_RS03065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J17_RS03070	COG1984	allophanate hydrolase subunit 2
I3J17_RS03100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J17_RS03105	COG2364	Membrane
I3J17_RS03115	COG2270	Major facilitator Superfamily
I3J17_RS03130	COG1216	Glycosyl transferase, family 2
I3J17_RS03150	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS03155	COG1309	transcriptional regulator
I3J17_RS03195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3J17_RS03200	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J17_RS03205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I3J17_RS03210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J17_RS03210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I3J17_RS03215	COG3201	nicotinamide mononucleotide transporter
I3J17_RS03230	COG1846	Transcriptional regulator
I3J17_RS03230	COG1940	carbohydrate kinase activity
I3J17_RS03235	COG0738	Major facilitator superfamily
I3J17_RS03245	COG2233	PERMEase
I3J17_RS03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J17_RS03270	COG1191	sigma factor activity
I3J17_RS03300	COG2390	Transcriptional regulator
I3J17_RS03305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J17_RS03315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J17_RS03330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3J17_RS03355	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J17_RS03360	COG0167	dihydroorotate dehydrogenase activity
I3J17_RS03365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J17_RS03370	COG0505	Belongs to the CarA family
I3J17_RS03380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J17_RS03385	COG0540	Belongs to the ATCase OTCase family
I3J17_RS03390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3J17_RS03400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J17_RS03405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I3J17_RS03410	COG0006	proline dipeptidase activity
I3J17_RS03420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3J17_RS03425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3J17_RS03430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J17_RS03435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I3J17_RS03440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J17_RS03445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J17_RS03450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I3J17_RS03455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3J17_RS03470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I3J17_RS03490	COG0124	histidyl-tRNA synthetase
I3J17_RS03500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J17_RS03505	COG1196	nuclear chromosome segregation
I3J17_RS03515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J17_RS03520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J17_RS03525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J17_RS03530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J17_RS03540	COG2255	four-way junction helicase activity
I3J17_RS03545	COG0632	four-way junction helicase activity
I3J17_RS03550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3J17_RS03555	COG0217	transcriptional regulatory protein
I3J17_RS03560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I3J17_RS03565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3J17_RS03575	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS03580	COG1560	Kdo2-lipid A biosynthetic process
I3J17_RS03585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J17_RS03605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J17_RS03610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I3J17_RS03615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J17_RS03665	COG0456	acetyltransferase
I3J17_RS03675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J17_RS03720	COG1648	precorrin-2 dehydrogenase activity
I3J17_RS03720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J17_RS03740	COG1464	Belongs to the NlpA lipoprotein family
I3J17_RS03745	COG2011	ABC-type metal ion transport system permease component
I3J17_RS03750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J17_RS03770	COG0584	glycerophosphoryl diester phosphodiesterase
I3J17_RS03775	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS03775	COG0204	Acyl-transferase
I3J17_RS03780	COG0477	Major facilitator Superfamily
I3J17_RS03790	COG0165	Argininosuccinate lyase
I3J17_RS03795	COG0137	argininosuccinate synthase activity
I3J17_RS03800	COG1438	arginine binding
I3J17_RS03805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J17_RS03810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3J17_RS03815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J17_RS03820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3J17_RS03825	COG2197	response regulator
I3J17_RS03830	COG4585	Histidine kinase
I3J17_RS03855	COG2838	Isocitrate dehydrogenase
I3J17_RS03865	COG0697	spore germination
I3J17_RS03875	COG1649	PFAM Uncharacterised BCR, COG1649
I3J17_RS03895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J17_RS03895	COG0072	phenylalanine-tRNA ligase activity
I3J17_RS03900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J17_RS03905	COG5002	protein histidine kinase activity
I3J17_RS03910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J17_RS03915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J17_RS03920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I3J17_RS03925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J17_RS03945	COG1404	Belongs to the peptidase S8 family
I3J17_RS03970	COG0174	glutamine synthetase
I3J17_RS03975	COG2186	Transcriptional regulator
I3J17_RS03980	COG1113	amino acid transport
I3J17_RS03985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J17_RS04005	COG4175	Glycine betaine
I3J17_RS04005	COG0517	IMP dehydrogenase activity
I3J17_RS04010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J17_RS04045	COG0805	protein transport
I3J17_RS04050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J17_RS04085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J17_RS04095	COG1609	Transcriptional regulator
I3J17_RS04100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J17_RS04105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I3J17_RS04120	COG4122	O-methyltransferase activity
I3J17_RS04125	COG1222	aaa ATPase
I3J17_RS04145	COG0517	IMP dehydrogenase activity
I3J17_RS04145	COG1994	Peptidase M50
I3J17_RS04155	COG2197	response regulator
I3J17_RS04170	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS04175	COG1410	methionine synthase
I3J17_RS04175	COG0646	methionine synthase
I3J17_RS04180	COG1414	Transcriptional regulator
I3J17_RS04185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J17_RS04190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J17_RS04195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J17_RS04200	COG2186	Transcriptional regulator
I3J17_RS04210	COG1129	ABC transporter
I3J17_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS04225	COG4948	Mandelate Racemase Muconate Lactonizing
I3J17_RS04235	COG0215	cysteine-tRNA ligase activity
I3J17_RS04255	COG0598	Magnesium transport protein CorA
I3J17_RS04265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS04270	COG0667	Aldo Keto reductase
I3J17_RS04300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J17_RS04330	COG1113	amino acid transport
I3J17_RS04335	COG2186	Transcriptional regulator
I3J17_RS04340	COG3265	gluconokinase activity
I3J17_RS04360	COG2149	membrane
I3J17_RS04375	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS04390	COG3876	Protein conserved in bacteria
I3J17_RS04425	COG2851	Citrate transporter
I3J17_RS04430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J17_RS04435	COG2188	Transcriptional regulator
I3J17_RS04440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J17_RS04450	COG2755	lipolytic protein G-D-S-L family
I3J17_RS04460	COG1725	Transcriptional regulator
I3J17_RS04485	COG4565	transcriptional regulatory protein
I3J17_RS04510	COG0596	Alpha beta hydrolase
I3J17_RS04515	COG3629	intracellular signal transduction
I3J17_RS04515	COG3903	Transcriptional regulator
I3J17_RS04530	COG0641	radical SAM
I3J17_RS04580	COG1799	cell septum assembly
I3J17_RS04585	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS04590	COG0477	Major facilitator Superfamily
I3J17_RS04595	COG0671	phosphoesterase, PA-phosphatase related
I3J17_RS04605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J17_RS04615	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS04635	COG1160	GTP binding
I3J17_RS04645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I3J17_RS04670	COG1056	cytidyltransferase-related domain
I3J17_RS04670	COG1051	belongs to the nudix hydrolase family
I3J17_RS04675	COG1187	pseudouridine synthase activity
I3J17_RS04680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3J17_RS04685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3J17_RS04700	COG0686	Belongs to the AlaDH PNT family
I3J17_RS04710	COG0494	nUDIX hydrolase
I3J17_RS04715	COG0504	CTP synthase activity
I3J17_RS04720	COG3387	PFAM Glycoside hydrolase 15-related
I3J17_RS04730	COG0297	glycogen (starch) synthase activity
I3J17_RS04735	COG0497	DNA recombination
I3J17_RS04740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J17_RS04760	COG1120	ATPase activity
I3J17_RS04765	COG0647	UMP catabolic process
I3J17_RS04800	COG2094	Belongs to the DNA glycosylase MPG family
I3J17_RS04810	COG1881	PFAM PEBP family protein
I3J17_RS04835	COG1119	ATPase activity
I3J17_RS04850	COG2197	response regulator
I3J17_RS04855	COG4585	Histidine kinase
I3J17_RS04865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I3J17_RS04875	COG1131	(ABC) transporter
I3J17_RS04875	COG0842	Transport permease protein
I3J17_RS04875	COG1716	ATPase activity
I3J17_RS04880	COG0560	Phosphoserine phosphatase
I3J17_RS04880	COG3830	Belongs to the UPF0237 family
I3J17_RS04895	COG2807	transmembrane transport
I3J17_RS04900	COG2186	Transcriptional regulator
I3J17_RS04905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J17_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS04925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I3J17_RS04945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I3J17_RS04950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J17_RS04960	COG1404	Belongs to the peptidase S8 family
I3J17_RS04995	COG3387	PFAM Glycoside hydrolase 15-related
I3J17_RS05035	COG1024	Enoyl-CoA hydratase
I3J17_RS05045	COG0488	(ABC) transporter
I3J17_RS05060	COG0235	Class ii aldolase
I3J17_RS05075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3J17_RS05080	COG1492	cobalamin metabolic process
I3J17_RS05095	COG1797	cobyrinic acid a,c-diamide synthase activity
I3J17_RS05125	COG0134	indole-3-glycerol-phosphate synthase activity
I3J17_RS05140	COG1917	Cupin 2, conserved barrel domain protein
I3J17_RS05145	COG5285	phytanoyl-CoA dioxygenase
I3J17_RS05150	COG1902	pentaerythritol trinitrate reductase activity
I3J17_RS05175	COG1414	Transcriptional regulator
I3J17_RS05180	COG4585	Histidine kinase
I3J17_RS05185	COG2197	response regulator
I3J17_RS05190	COG0768	penicillin binding
I3J17_RS05200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J17_RS05210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J17_RS05215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J17_RS05230	COG1802	Transcriptional regulator
I3J17_RS05245	COG0745	RESPONSE REGULATOR receiver
I3J17_RS05250	COG2205	protein histidine kinase activity
I3J17_RS05300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J17_RS05310	COG2171	N-acyltransferase activity
I3J17_RS05315	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J17_RS05320	COG0822	iron-sulfur transferase activity
I3J17_RS05325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J17_RS05330	COG0396	ATPase activity
I3J17_RS05340	COG0719	Fe-S assembly protein
I3J17_RS05355	COG1131	(ABC) transporter
I3J17_RS05385	COG0109	protoheme IX farnesyltransferase activity
I3J17_RS05395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3J17_RS05410	COG0363	glucosamine-6-phosphate deaminase activity
I3J17_RS05420	COG3402	PFAM membrane-flanked domain
I3J17_RS05425	COG0166	Belongs to the GPI family
I3J17_RS05435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J17_RS05440	COG0149	triose-phosphate isomerase activity
I3J17_RS05445	COG0126	phosphoglycerate kinase activity
I3J17_RS05450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J17_RS05460	COG1481	regulation of sporulation
I3J17_RS05465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J17_RS05470	COG1660	Displays ATPase and GTPase activities
I3J17_RS05475	COG0322	excinuclease ABC activity
I3J17_RS05500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J17_RS05500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3J17_RS05505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J17_RS05515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J17_RS05535	COG0556	nucleotide-excision repair
I3J17_RS05545	COG0584	glycerophosphoryl diester phosphodiesterase
I3J17_RS05550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J17_RS05560	COG2313	pseudouridylate synthase activity
I3J17_RS05590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J17_RS05595	COG0330	HflC and HflK could
I3J17_RS05615	COG0237	dephospho-CoA kinase activity
I3J17_RS05625	COG0539	negative regulation of cytoplasmic translation
I3J17_RS05630	COG2226	methyltransferase
I3J17_RS05630	COG0596	Alpha beta hydrolase
I3J17_RS05630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J17_RS05635	COG1643	Atp-dependent helicase
I3J17_RS05665	COG2050	protein possibly involved in aromatic compounds catabolism
I3J17_RS05685	COG0411	ABC transporter
I3J17_RS05735	COG0287	Prephenate dehydrogenase
I3J17_RS05735	COG1605	Chorismate mutase
I3J17_RS05750	COG1470	cell adhesion involved in biofilm formation
I3J17_RS05750	COG0366	Alpha amylase catalytic
I3J17_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS05775	COG1024	Enoyl-CoA hydratase
I3J17_RS05805	COG0183	Belongs to the thiolase family
I3J17_RS05810	COG1309	transcriptional regulator
I3J17_RS05820	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS05845	COG0070	glutamate synthase
I3J17_RS05845	COG0069	glutamate synthase activity
I3J17_RS05845	COG0067	glutamate synthase
I3J17_RS05880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J17_RS05885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J17_RS05890	COG2301	Belongs to the HpcH HpaI aldolase family
I3J17_RS05895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I3J17_RS05905	COG0159	tryptophan synthase activity
I3J17_RS05910	COG0133	tryptophan synthase activity
I3J17_RS05920	COG0134	indole-3-glycerol-phosphate synthase activity
I3J17_RS05940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J17_RS05945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J17_RS05960	COG0107	imidazoleglycerol-phosphate synthase activity
I3J17_RS05965	COG0251	oxidation-reduction process
I3J17_RS05970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I3J17_RS05975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3J17_RS05985	COG0131	Imidazoleglycerol-phosphate dehydratase
I3J17_RS05990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J17_RS05995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J17_RS06015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J17_RS06035	COG1432	Conserved Protein
I3J17_RS06045	COG0587	DNA-directed DNA polymerase activity
I3J17_RS06095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3J17_RS06110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J17_RS06115	COG3599	regulation of cell shape
I3J17_RS06125	COG1799	cell septum assembly
I3J17_RS06135	COG1496	oxidoreductase activity
I3J17_RS06145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J17_RS06150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J17_RS06160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J17_RS06165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J17_RS06170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J17_RS06175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3J17_RS06180	COG0768	penicillin binding
I3J17_RS06190	COG0275	rRNA processing
I3J17_RS06200	COG0714	Associated with various cellular activities
I3J17_RS06230	COG1121	(ABC) transporter
I3J17_RS06235	COG1511	domain protein
I3J17_RS06240	COG1309	transcriptional regulator
I3J17_RS06250	COG1233	COG1233 Phytoene dehydrogenase and related
I3J17_RS06265	COG0352	thiamine-phosphate diphosphorylase activity
I3J17_RS06285	COG2022	thiamine diphosphate biosynthetic process
I3J17_RS06285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J17_RS06295	COG2022	thiamine diphosphate biosynthetic process
I3J17_RS06305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I3J17_RS06310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J17_RS06315	COG2193	ferroxidase activity
I3J17_RS06320	COG0243	molybdopterin cofactor binding
I3J17_RS06325	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3J17_RS06335	COG0205	6-phosphofructokinase activity
I3J17_RS06340	COG2197	response regulator
I3J17_RS06370	COG1940	carbohydrate kinase activity
I3J17_RS06380	COG0003	Pfam Anion-transporting ATPase
I3J17_RS06405	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS06455	COG2205	protein histidine kinase activity
I3J17_RS06460	COG0745	RESPONSE REGULATOR receiver
I3J17_RS06470	COG1929	Belongs to the glycerate kinase type-1 family
I3J17_RS06475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J17_RS06480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3J17_RS06485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J17_RS06490	COG0723	plastoquinol--plastocyanin reductase activity
I3J17_RS06495	COG2010	Cytochrome c
I3J17_RS06500	COG1845	cytochrome c oxidase, subunit III
I3J17_RS06510	COG1376	ErfK ybiS ycfS ynhG family protein
I3J17_RS06520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J17_RS06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J17_RS06535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J17_RS06555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3J17_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J17_RS06570	COG2197	response regulator
I3J17_RS06575	COG4585	Histidine kinase
I3J17_RS06600	COG1132	(ABC) transporter
I3J17_RS06605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J17_RS06635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3J17_RS06645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3J17_RS06650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I3J17_RS06655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J17_RS06660	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J17_RS06670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J17_RS06700	COG1090	epimerase
I3J17_RS06715	COG0321	lipoyl(octanoyl) transferase activity
I3J17_RS06720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3J17_RS06770	COG0181	hydroxymethylbilane synthase activity
I3J17_RS06795	COG0673	inositol 2-dehydrogenase activity
I3J17_RS06805	COG0745	RESPONSE REGULATOR receiver
I3J17_RS06845	COG2197	response regulator
I3J17_RS06875	COG1175	transmembrane transport
I3J17_RS06880	COG3833	ABC-type maltose transport systems, permease component
I3J17_RS06885	COG0366	Alpha amylase catalytic
I3J17_RS06890	COG1609	Transcriptional regulator
I3J17_RS06910	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J17_RS06925	COG0494	nUDIX hydrolase
I3J17_RS06930	COG2154	pterin-4-alpha-carbinolamine dehydratase
I3J17_RS06955	COG1228	amidohydrolase
I3J17_RS06970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3J17_RS06985	COG0174	glutamine synthetase
I3J17_RS07020	COG2132	Multicopper oxidase
I3J17_RS07025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I3J17_RS07025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J17_RS07035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I3J17_RS07055	COG1994	Peptidase M50
I3J17_RS07090	COG5398	heme oxygenase
I3J17_RS07115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS07120	COG1120	ATPase activity
I3J17_RS07140	COG1834	amidinotransferase
I3J17_RS07155	COG2814	Major facilitator Superfamily
I3J17_RS07160	COG3540	Alkaline phosphatase
I3J17_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS07210	COG0395	ABC-type sugar transport system, permease component
I3J17_RS07220	COG1653	transport
I3J17_RS07225	COG1349	DNA-binding transcription factor activity
I3J17_RS07245	COG0789	Transcriptional regulator
I3J17_RS07260	COG3022	response to hydroperoxide
I3J17_RS07265	COG0800	Aldolase
I3J17_RS07285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J17_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS07305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I3J17_RS07310	COG2030	dehydratase
I3J17_RS07325	COG0183	Belongs to the thiolase family
I3J17_RS07345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS07355	COG2226	methyltransferase
I3J17_RS07360	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS07365	COG1309	transcriptional regulator
I3J17_RS07400	COG3845	ABC transporter
I3J17_RS07415	COG0183	Belongs to the thiolase family
I3J17_RS07420	COG2124	cytochrome p450
I3J17_RS07430	COG4122	O-methyltransferase activity
I3J17_RS07540	COG0582	viral genome integration into host DNA
I3J17_RS07565	COG0586	Pfam SNARE associated Golgi protein
I3J17_RS07575	COG1358	cellular component organization or biogenesis
I3J17_RS07620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3J17_RS07625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J17_RS07645	COG4585	Histidine kinase
I3J17_RS07650	COG2197	response regulator
I3J17_RS07655	COG0667	Aldo Keto reductase
I3J17_RS07660	COG0789	Transcriptional regulator
I3J17_RS07685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J17_RS07690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J17_RS07695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J17_RS07730	COG2130	NADP-dependent
I3J17_RS07785	COG1136	(ABC) transporter
I3J17_RS07795	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS07855	COG0842	Transport permease protein
I3J17_RS07855	COG1129	ABC transporter
I3J17_RS07890	COG1070	Carbohydrate kinase
I3J17_RS07905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J17_RS07910	COG0358	DNA primase activity
I3J17_RS07920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I3J17_RS07925	COG2949	membrane
I3J17_RS07945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J17_RS07965	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J17_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS07980	COG0531	amino acid
I3J17_RS07995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J17_RS07995	COG0574	Belongs to the PEP-utilizing enzyme family
I3J17_RS08035	COG0423	glycine-tRNA ligase activity
I3J17_RS08040	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J17_RS08040	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3J17_RS08045	COG3842	ATPase activity
I3J17_RS08050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J17_RS08060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J17_RS08065	COG1381	Involved in DNA repair and RecF pathway recombination
I3J17_RS08080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J17_RS08095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J17_RS08135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I3J17_RS08145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J17_RS08150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J17_RS08155	COG1234	tRNA 3'-trailer cleavage
I3J17_RS08160	COG0537	adenosine 5'-monophosphoramidase activity
I3J17_RS08165	COG4946	Tricorn protease homolog
I3J17_RS08165	COG0793	Belongs to the peptidase S41A family
I3J17_RS08185	COG0484	heat shock protein binding
I3J17_RS08190	COG1420	regulation of RNA biosynthetic process
I3J17_RS08215	COG0481	GTPase activity
I3J17_RS08220	COG0268	Binds directly to 16S ribosomal RNA
I3J17_RS08255	COG1307	EDD domain protein, DegV family
I3J17_RS08265	COG0495	leucyl-tRNA aminoacylation
I3J17_RS08275	COG0588	phosphoglycerate mutase activity
I3J17_RS08280	COG0799	negative regulation of ribosome biogenesis
I3J17_RS08290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3J17_RS08300	COG0501	Belongs to the peptidase M48B family
I3J17_RS08315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3J17_RS08325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J17_RS08340	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS08345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I3J17_RS08350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J17_RS08355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I3J17_RS08365	COG1530	ribonuclease E activity
I3J17_RS08385	COG0772	Belongs to the SEDS family
I3J17_RS08405	COG1077	Cell shape determining protein MreB Mrl
I3J17_RS08410	COG0105	UTP biosynthetic process
I3J17_RS08420	COG0285	dihydrofolate synthase activity
I3J17_RS08425	COG4585	Histidine kinase
I3J17_RS08430	COG0525	valine-tRNA ligase activity
I3J17_RS08440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I3J17_RS08445	COG0740	serine-type endopeptidase activity
I3J17_RS08450	COG0740	serine-type endopeptidase activity
I3J17_RS08455	COG0544	peptidyl-prolyl cis-trans isomerase activity
I3J17_RS08475	COG3594	Acyltransferase
I3J17_RS08480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J17_RS08495	COG0475	glutathione-regulated potassium exporter activity
I3J17_RS08510	COG4552	Acetyltransferase involved in intracellular survival and related
I3J17_RS08525	COG1113	amino acid transport
I3J17_RS08535	COG1113	amino acid transport
I3J17_RS08540	COG0588	phosphoglycerate mutase activity
I3J17_RS08550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J17_RS08560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J17_RS08565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J17_RS08635	COG0668	transmembrane transport
I3J17_RS08655	COG1175	transmembrane transport
I3J17_RS08660	COG0395	ABC-type sugar transport system, permease component
I3J17_RS08665	COG1486	melibiose metabolic process
I3J17_RS08680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J17_RS08725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J17_RS08755	COG0629	single-stranded DNA binding
I3J17_RS08795	COG1203	CRISPR-associated helicase, Cas3
I3J17_RS08805	COG1518	maintenance of DNA repeat elements
I3J17_RS08810	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I3J17_RS08820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J17_RS08850	COG0475	glutathione-regulated potassium exporter activity
I3J17_RS08860	COG0561	phosphatase activity
I3J17_RS08890	COG0494	nUDIX hydrolase
I3J17_RS08900	COG2954	triphosphatase activity
I3J17_RS08910	COG2197	response regulator
I3J17_RS08915	COG0105	UTP biosynthetic process
I3J17_RS08975	COG1131	(ABC) transporter
I3J17_RS08995	COG3962	Belongs to the TPP enzyme family
I3J17_RS09000	COG3718	enzyme involved in inositol metabolism
I3J17_RS09010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J17_RS09035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J17_RS09045	COG1595	DNA-templated transcription, initiation
I3J17_RS09060	COG0673	inositol 2-dehydrogenase activity
I3J17_RS09065	COG1609	Transcriptional regulator
I3J17_RS09080	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J17_RS09145	COG1674	ftsk spoiiie
I3J17_RS09165	COG3960	tartronate-semialdehyde synthase activity
I3J17_RS09175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J17_RS09190	COG1946	Acyl-CoA thioesterase
I3J17_RS09195	COG2124	cytochrome p450
I3J17_RS09205	COG1309	transcriptional regulator
I3J17_RS09210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J17_RS09225	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS09235	COG0076	glutamate decarboxylase activity
I3J17_RS09240	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3J17_RS09265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J17_RS09270	COG0589	response to stress
I3J17_RS09280	COG4977	sequence-specific DNA binding
I3J17_RS09285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3J17_RS09300	COG0745	RESPONSE REGULATOR receiver
I3J17_RS09340	COG0406	alpha-ribazole phosphatase activity
I3J17_RS09375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS09385	COG0154	amidase activity
I3J17_RS09395	COG0765	amino acid transport
I3J17_RS09400	COG0765	amino acid transport
I3J17_RS09405	COG1126	abc transporter atp-binding protein
I3J17_RS09475	COG0673	inositol 2-dehydrogenase activity
I3J17_RS09485	COG0706	membrane insertase activity
I3J17_RS09515	COG2733	membrane
I3J17_RS09525	COG1131	(ABC) transporter
I3J17_RS09540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J17_RS09550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J17_RS09580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J17_RS09590	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I3J17_RS09595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J17_RS09600	COG1263	PTS System
I3J17_RS09605	COG1263	PTS System
I3J17_RS09610	COG1234	tRNA 3'-trailer cleavage
I3J17_RS09625	COG1120	ATPase activity
I3J17_RS09630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS09635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J17_RS09645	COG1113	amino acid transport
I3J17_RS09655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I3J17_RS09665	COG1335	isochorismatase
I3J17_RS09705	COG0277	FAD linked oxidase domain protein
I3J17_RS09725	COG5002	protein histidine kinase activity
I3J17_RS09730	COG0745	RESPONSE REGULATOR receiver
I3J17_RS09735	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3J17_RS09760	COG3654	unkown
I3J17_RS09800	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J17_RS09805	COG0395	ABC-type sugar transport system, permease component
I3J17_RS09810	COG1175	transmembrane transport
I3J17_RS09825	COG1678	Uncharacterized ACR, COG1678
I3J17_RS09830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J17_RS09835	COG0776	regulation of translation
I3J17_RS09845	COG3973	AAA domain
I3J17_RS09870	COG0583	DNA-binding transcription factor activity
I3J17_RS09885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I3J17_RS09890	COG0793	Belongs to the peptidase S41A family
I3J17_RS09900	COG2884	Cell division ATP-binding protein ftsE
I3J17_RS09910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J17_RS09915	COG0515	serine threonine protein kinase
I3J17_RS09920	COG0515	serine threonine protein kinase
I3J17_RS09935	COG1175	transmembrane transport
I3J17_RS09940	COG0395	ABC-type sugar transport system, permease component
I3J17_RS09950	COG2902	Dehydrogenase
I3J17_RS09975	COG0653	protein targeting
I3J17_RS09985	COG3214	Protein conserved in bacteria
I3J17_RS09990	COG2197	response regulator
I3J17_RS09995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J17_RS10005	COG0823	Involved in the tonB-independent uptake of proteins
I3J17_RS10010	COG5002	protein histidine kinase activity
I3J17_RS10010	COG5000	phosphorelay sensor kinase activity
I3J17_RS10015	COG0745	RESPONSE REGULATOR receiver
I3J17_RS10020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I3J17_RS10030	COG2826	transposase and inactivated derivatives, IS30 family
I3J17_RS10055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3J17_RS10065	COG1482	cell wall glycoprotein biosynthetic process
I3J17_RS10075	COG2835	tetraacyldisaccharide 4'-kinase activity
I3J17_RS10080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J17_RS10115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J17_RS10120	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3J17_RS10120	COG0778	Nitroreductase
I3J17_RS10145	COG1316	TRANSCRIPTIONal
I3J17_RS10165	COG1316	TRANSCRIPTIONal
I3J17_RS10170	COG1607	acyl-coa hydrolase
I3J17_RS10175	COG1316	TRANSCRIPTIONal
I3J17_RS10180	COG0596	Alpha beta hydrolase
I3J17_RS10185	COG1309	transcriptional regulator
I3J17_RS10270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J17_RS10305	COG2205	protein histidine kinase activity
I3J17_RS10310	COG0745	RESPONSE REGULATOR receiver
I3J17_RS10315	COG3104	oligopeptide transport
I3J17_RS10340	COG1191	sigma factor activity
I3J17_RS10365	COG1228	amidohydrolase
I3J17_RS10395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I3J17_RS10455	COG1737	Transcriptional regulator
I3J17_RS10470	COG2755	lipolytic protein G-D-S-L family
I3J17_RS10475	COG0183	Belongs to the thiolase family
I3J17_RS10505	COG0577	efflux transmembrane transporter activity
I3J17_RS10505	COG1136	(ABC) transporter
I3J17_RS10510	COG1136	(ABC) transporter
I3J17_RS10510	COG0577	efflux transmembrane transporter activity
I3J17_RS10515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J17_RS10520	COG1252	NADH dehydrogenase
I3J17_RS10540	COG0148	phosphopyruvate hydratase activity
I3J17_RS10550	COG1652	LysM domain
I3J17_RS10580	COG2815	serine threonine protein kinase
I3J17_RS10580	COG0515	serine threonine protein kinase
I3J17_RS10605	COG1595	DNA-templated transcription, initiation
I3J17_RS10615	COG0577	efflux transmembrane transporter activity
I3J17_RS10620	COG1136	(ABC) transporter
I3J17_RS10635	COG0477	Major facilitator Superfamily
I3J17_RS10665	COG4585	Histidine kinase
I3J17_RS10675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I3J17_RS10680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J17_RS10685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3J17_RS10690	COG0193	aminoacyl-tRNA hydrolase activity
I3J17_RS10700	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3J17_RS10710	COG1309	transcriptional regulator
I3J17_RS10715	COG4106	trans-aconitate 2-methyltransferase activity
I3J17_RS10725	COG2197	response regulator
I3J17_RS10730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J17_RS10760	COG0488	(ABC) transporter
I3J17_RS10785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3J17_RS10790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J17_RS10800	COG0084	hydrolase, TatD family'
I3J17_RS10830	COG0442	prolyl-tRNA aminoacylation
I3J17_RS10850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J17_RS10855	COG3409	Peptidoglycan-binding domain 1 protein
I3J17_RS10880	COG0124	histidyl-tRNA synthetase
I3J17_RS10920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J17_RS10925	COG1122	ATPase activity
I3J17_RS10935	COG0310	cobalt ion transport
I3J17_RS10945	COG2409	Drug exporters of the RND superfamily
I3J17_RS10955	COG0793	Belongs to the peptidase S41A family
I3J17_RS10955	COG4946	Tricorn protease homolog
I3J17_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS10965	COG2267	carboxylic ester hydrolase activity
I3J17_RS10970	COG2072	flavoprotein involved in K transport
I3J17_RS11015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J17_RS11020	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J17_RS11020	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J17_RS11025	COG0315	cyclic pyranopterin monophosphate synthase activity
I3J17_RS11035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J17_RS11040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J17_RS11065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J17_RS11075	COG1970	mechanosensitive ion channel activity
I3J17_RS11090	COG3191	aminopeptidase activity
I3J17_RS11100	COG0477	Major facilitator Superfamily
I3J17_RS11120	COG3384	dioxygenase
I3J17_RS11125	COG1846	Transcriptional regulator
I3J17_RS11150	COG1648	precorrin-2 dehydrogenase activity
I3J17_RS11150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J17_RS11155	COG0181	hydroxymethylbilane synthase activity
I3J17_RS11160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I3J17_RS11165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I3J17_RS11180	COG1595	DNA-templated transcription, initiation
I3J17_RS11215	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J17_RS11240	COG0180	Tryptophanyl-tRNA synthetase
I3J17_RS11245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J17_RS11250	COG1252	NADH dehydrogenase
I3J17_RS11255	COG1595	DNA-templated transcription, initiation
I3J17_RS11260	COG2226	methyltransferase
I3J17_RS11280	COG0129	dihydroxy-acid dehydratase activity
I3J17_RS11290	COG0248	Ppx GppA phosphatase
I3J17_RS11310	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J17_RS11320	COG0671	phosphoesterase, PA-phosphatase related
I3J17_RS11325	COG1194	a g-specific adenine glycosylase
I3J17_RS11330	COG1595	DNA-templated transcription, initiation
I3J17_RS11340	COG0745	RESPONSE REGULATOR receiver
I3J17_RS11345	COG2205	protein histidine kinase activity
I3J17_RS11350	COG0739	heme binding
I3J17_RS11360	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J17_RS11375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J17_RS11395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I3J17_RS11405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J17_RS11410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I3J17_RS11425	COG2197	response regulator
I3J17_RS11440	COG0649	NAD binding
I3J17_RS11455	COG1174	glycine betaine transport
I3J17_RS11480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J17_RS11495	COG0302	gtp cyclohydrolase
I3J17_RS11510	COG0037	tRNA processing
I3J17_RS11520	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J17_RS11525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3J17_RS11540	COG0076	glutamate decarboxylase activity
I3J17_RS11555	COG2318	DinB family
I3J17_RS11560	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS11600	COG0110	maltose O-acetyltransferase activity
I3J17_RS11605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J17_RS11605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J17_RS11610	COG1132	(ABC) transporter
I3J17_RS11720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I3J17_RS11880	COG0305	Participates in initiation and elongation during chromosome replication
I3J17_RS11960	COG0791	NLP P60 protein
I3J17_RS12005	COG1061	Type III restriction enzyme res subunit
I3J17_RS12045	COG0477	Major facilitator Superfamily
I3J17_RS12055	COG0470	DNA polymerase III
I3J17_RS12060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3J17_RS12065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J17_RS12065	COG1754	DNA topoisomerase type I activity
I3J17_RS12075	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J17_RS12085	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I3J17_RS12090	COG2172	sigma factor antagonist activity
I3J17_RS12095	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J17_RS12100	COG1111	helicase
I3J17_RS12100	COG1205	dead DEAH box helicase
I3J17_RS12160	COG0659	secondary active sulfate transmembrane transporter activity
I3J17_RS12165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J17_RS12170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J17_RS12180	COG2267	carboxylic ester hydrolase activity
I3J17_RS12210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J17_RS12240	COG0003	Pfam Anion-transporting ATPase
I3J17_RS12250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J17_RS12255	COG1610	YqeY-like protein
I3J17_RS12260	COG1408	metallophosphoesterase
I3J17_RS12280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J17_RS12365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J17_RS12395	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I3J17_RS12410	COG2091	lysine biosynthetic process via aminoadipic acid
I3J17_RS12425	COG2124	cytochrome p450
I3J17_RS12450	COG1595	DNA-templated transcription, initiation
I3J17_RS12455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J17_RS12470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I3J17_RS12475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J17_RS12490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I3J17_RS12525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS12530	COG2319	Wd-40 repeat
I3J17_RS12530	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J17_RS12545	COG1802	Transcriptional regulator
I3J17_RS12550	COG0463	Glycosyl transferase, family 2
I3J17_RS12580	COG2124	cytochrome p450
I3J17_RS12590	COG4585	Histidine kinase
I3J17_RS12625	COG0477	Major facilitator Superfamily
I3J17_RS12630	COG0191	fructose-bisphosphate aldolase activity
I3J17_RS12635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J17_RS12650	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J17_RS12680	COG0542	response to heat
I3J17_RS12700	COG0789	Transcriptional regulator
I3J17_RS12705	COG0484	heat shock protein binding
I3J17_RS12710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3J17_RS12715	COG0443	Heat shock 70 kDa protein
I3J17_RS12720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J17_RS12725	COG2181	nitrate reductase activity
I3J17_RS12725	COG0247	lactate metabolic process
I3J17_RS12740	COG0717	Belongs to the dCTP deaminase family
I3J17_RS12790	COG0588	phosphoglycerate mutase activity
I3J17_RS12795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J17_RS12805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J17_RS12830	COG2409	Drug exporters of the RND superfamily
I3J17_RS12835	COG4585	Histidine kinase
I3J17_RS12840	COG2197	response regulator
I3J17_RS12855	COG4171	peptide transport system, permease
I3J17_RS12860	COG0601	transmembrane transport
I3J17_RS12865	COG4166	transmembrane transport
I3J17_RS12880	COG0019	diaminopimelate decarboxylase activity
I3J17_RS12885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J17_RS12890	COG0534	Mate efflux family protein
I3J17_RS12900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3J17_RS12950	COG3903	Transcriptional regulator
I3J17_RS12950	COG3629	intracellular signal transduction
I3J17_RS12975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J17_RS13035	COG0577	efflux transmembrane transporter activity
I3J17_RS13045	COG2197	response regulator
I3J17_RS13060	COG0436	Aminotransferase
I3J17_RS13080	COG1857	crispr-associated protein
I3J17_RS13185	COG2826	transposase and inactivated derivatives, IS30 family
I3J17_RS13225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J17_RS13230	COG2226	methyltransferase
I3J17_RS13240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J17_RS13320	COG3345	alpha-galactosidase
I3J17_RS13325	COG0598	Magnesium transport protein CorA
I3J17_RS13355	COG0431	NADPH-dependent FMN reductase
I3J17_RS13360	COG1672	PFAM Archaeal ATPase
I3J17_RS13360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J17_RS13385	COG0431	NADPH-dependent FMN reductase
I3J17_RS13405	COG0477	Major facilitator Superfamily
I3J17_RS13410	COG0745	RESPONSE REGULATOR receiver
I3J17_RS13440	COG0784	Response regulator, receiver
I3J17_RS13445	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS13450	COG1595	DNA-templated transcription, initiation
I3J17_RS13475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J17_RS13480	COG0587	DNA-directed DNA polymerase activity
I3J17_RS13510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J17_RS13540	COG0006	proline dipeptidase activity
I3J17_RS13560	COG1999	signal sequence binding
I3J17_RS13575	COG2837	iron assimilation
I3J17_RS13580	COG0077	Prephenate dehydratase
I3J17_RS13585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I3J17_RS13590	COG0561	phosphatase activity
I3J17_RS13625	COG1131	(ABC) transporter
I3J17_RS13635	COG0561	phosphatase activity
I3J17_RS13645	COG4988	ABC transporter
I3J17_RS13650	COG1294	oxidase, subunit
I3J17_RS13655	COG1271	oxidase subunit
I3J17_RS13660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3J17_RS13665	COG1609	Transcriptional regulator
I3J17_RS13680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I3J17_RS13700	COG0662	Cupin 2, conserved barrel domain protein
I3J17_RS13705	COG1950	PFAM Membrane protein of
I3J17_RS13710	COG0626	cystathionine gamma-synthase activity
I3J17_RS13745	COG0305	Participates in initiation and elongation during chromosome replication
I3J17_RS13755	COG0359	binds to the 23S rRNA
I3J17_RS13760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3J17_RS13765	COG0629	single-stranded DNA binding
I3J17_RS13770	COG0360	Binds together with S18 to 16S ribosomal RNA
I3J17_RS13795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J17_RS13815	COG0617	tRNA 3'-terminal CCA addition
I3J17_RS13830	COG2815	serine threonine protein kinase
I3J17_RS13830	COG0515	serine threonine protein kinase
I3J17_RS13835	COG1595	DNA-templated transcription, initiation
I3J17_RS13845	COG0492	ferredoxin-NADP+ reductase activity
I3J17_RS13850	COG3118	belongs to the thioredoxin family
I3J17_RS13865	COG1192	Involved in chromosome partitioning
I3J17_RS13870	COG0357	Ribosomal RNA small subunit methyltransferase G
I3J17_RS13880	COG0706	membrane insertase activity
I3J17_RS13885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I3J17_RS13890	COG0594	ribonuclease P activity
I3J17_RS13895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I3J17_RS13905	COG0592	DNA-directed DNA polymerase activity
I3J17_RS13910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3J17_RS13915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3J17_RS13920	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3J17_RS13930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J17_RS13950	COG0515	serine threonine protein kinase
I3J17_RS13965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS13975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J17_RS13980	COG2175	clavaminate synthase activity
I3J17_RS13985	COG0667	Aldo Keto reductase
I3J17_RS14000	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J17_RS14000	COG1672	PFAM Archaeal ATPase
I3J17_RS14005	COG1280	lysine exporter protein (LysE YggA)
I3J17_RS14010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J17_RS14015	COG1446	asparaginase
I3J17_RS14045	COG0705	Rhomboid family
I3J17_RS14045	COG0457	Tetratricopeptide repeat
I3J17_RS14060	COG3764	Sortase (surface protein transpeptidase)
I3J17_RS14075	COG3764	Sortase (surface protein transpeptidase)
I3J17_RS14080	COG3764	Sortase (surface protein transpeptidase)
I3J17_RS14085	COG0515	serine threonine protein kinase
I3J17_RS14090	COG0768	penicillin binding
I3J17_RS14105	COG1716	ATPase activity
I3J17_RS14110	COG1716	ATPase activity
I3J17_RS14120	COG0577	efflux transmembrane transporter activity
I3J17_RS14120	COG1136	(ABC) transporter
I3J17_RS14125	COG1136	(ABC) transporter
I3J17_RS14125	COG0577	efflux transmembrane transporter activity
I3J17_RS14150	COG4585	Histidine kinase
I3J17_RS14155	COG2197	response regulator
I3J17_RS14170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J17_RS14175	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS14180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J17_RS14185	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J17_RS14190	COG3396	Phenylacetate-CoA oxygenase
I3J17_RS14195	COG3460	Phenylacetate-CoA oxygenase
I3J17_RS14200	COG3396	Phenylacetate-CoA oxygenase
I3J17_RS14225	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J17_RS14230	COG1309	transcriptional regulator
I3J17_RS14235	COG1522	sequence-specific DNA binding
I3J17_RS14260	COG0303	'Molybdopterin
I3J17_RS14290	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J17_RS14290	COG1136	(ABC) transporter
I3J17_RS14305	COG0515	serine threonine protein kinase
I3J17_RS14310	COG0515	serine threonine protein kinase
I3J17_RS14335	COG0022	dehydrogenase e1 component
I3J17_RS14340	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J17_RS14355	COG2271	Major facilitator Superfamily
I3J17_RS14375	COG1362	aminopeptidase activity
I3J17_RS14385	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS14410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I3J17_RS14430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J17_RS14435	COG0745	RESPONSE REGULATOR receiver
I3J17_RS14440	COG2205	protein histidine kinase activity
I3J17_RS14445	COG2304	oxidoreductase activity
I3J17_RS14495	COG1191	sigma factor activity
I3J17_RS14500	COG1191	sigma factor activity
I3J17_RS14545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I3J17_RS14560	COG0433	COG0433 Predicted ATPase
I3J17_RS14565	COG2234	aminopeptidase activity
I3J17_RS14595	COG0477	Major facilitator Superfamily
I3J17_RS14660	COG3903	Transcriptional regulator
I3J17_RS14660	COG3629	intracellular signal transduction
I3J17_RS14690	COG2826	transposase and inactivated derivatives, IS30 family
I3J17_RS14730	COG0105	UTP biosynthetic process
I3J17_RS14740	COG1051	belongs to the nudix hydrolase family
I3J17_RS14745	COG0017	Asparaginyl-tRNA synthetase
I3J17_RS14770	COG0151	Belongs to the GarS family
I3J17_RS14785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J17_RS14795	COG2197	response regulator
I3J17_RS14830	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J17_RS14835	COG0047	phosphoribosylformylglycinamidine synthase activity
I3J17_RS14840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J17_RS14870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3J17_RS14905	COG1643	Atp-dependent helicase
I3J17_RS14915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3J17_RS14915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J17_RS14920	COG0785	Cytochrome C biogenesis protein
I3J17_RS14955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J17_RS14960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J17_RS14970	COG0513	Belongs to the DEAD box helicase family
I3J17_RS14980	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J17_RS15035	COG0741	lytic transglycosylase activity
I3J17_RS15035	COG1196	nuclear chromosome segregation
I3J17_RS15035	COG0739	heme binding
I3J17_RS15045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I3J17_RS15050	COG0579	oxidoreductase
I3J17_RS15145	COG0739	heme binding
I3J17_RS15145	COG0741	lytic transglycosylase activity
I3J17_RS15145	COG1196	nuclear chromosome segregation
I3J17_RS15150	COG0671	phosphoesterase, PA-phosphatase related
I3J17_RS15170	COG1937	Protein conserved in bacteria
I3J17_RS15180	COG0306	phosphate transporter
I3J17_RS15205	COG0494	nUDIX hydrolase
I3J17_RS15205	COG0406	alpha-ribazole phosphatase activity
I3J17_RS15215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3J17_RS15220	COG0456	acetyltransferase
I3J17_RS15240	COG0737	Belongs to the 5'-nucleotidase family
I3J17_RS15240	COG4085	toxin activity
I3J17_RS15240	COG1525	nuclease
I3J17_RS15250	COG2188	Transcriptional regulator
I3J17_RS15265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J17_RS15280	COG1609	Transcriptional regulator
I3J17_RS15285	COG0745	RESPONSE REGULATOR receiver
I3J17_RS15305	COG1309	transcriptional regulator
I3J17_RS15330	COG3485	protocatechuate 3,4-dioxygenase
I3J17_RS15345	COG1490	D-aminoacyl-tRNA deacylase activity
I3J17_RS15405	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS15430	COG2211	Major facilitator Superfamily
I3J17_RS15435	COG0588	phosphoglycerate mutase activity
I3J17_RS15450	COG5002	protein histidine kinase activity
I3J17_RS15465	COG1329	Transcriptional regulator
I3J17_RS15470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3J17_RS15475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I3J17_RS15485	COG0215	cysteine-tRNA ligase activity
I3J17_RS15490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J17_RS15500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I3J17_RS15510	COG3842	ATPase activity
I3J17_RS15525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J17_RS15590	COG0463	Glycosyl transferase, family 2
I3J17_RS15615	COG2182	Extracellular solute-binding protein
I3J17_RS15620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J17_RS15635	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J17_RS15640	COG0191	fructose-bisphosphate aldolase activity
I3J17_RS15665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3J17_RS15685	COG2197	response regulator
I3J17_RS15705	COG1605	Chorismate mutase
I3J17_RS15710	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS15720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I3J17_RS15725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I3J17_RS15800	COG1595	DNA-templated transcription, initiation
I3J17_RS15815	COG3973	AAA domain
I3J17_RS15825	COG1061	Type III restriction enzyme res subunit
I3J17_RS15860	COG1278	Cold shock
I3J17_RS15865	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J17_RS15870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3J17_RS15880	COG2814	Major facilitator Superfamily
I3J17_RS15900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J17_RS15910	COG2252	PERMEase
I3J17_RS15945	COG0667	Aldo Keto reductase
I3J17_RS15965	COG1122	ATPase activity
I3J17_RS16005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J17_RS16020	COG3629	intracellular signal transduction
I3J17_RS16020	COG3903	Transcriptional regulator
I3J17_RS16030	COG0463	Glycosyl transferase, family 2
I3J17_RS16070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J17_RS16080	COG0277	FAD linked oxidase domain protein
I3J17_RS16080	COG0247	lactate metabolic process
I3J17_RS16095	COG0745	RESPONSE REGULATOR receiver
I3J17_RS16100	COG2205	protein histidine kinase activity
I3J17_RS16115	COG0583	DNA-binding transcription factor activity
I3J17_RS16150	COG1136	(ABC) transporter
I3J17_RS16150	COG0577	efflux transmembrane transporter activity
I3J17_RS16155	COG0577	efflux transmembrane transporter activity
I3J17_RS16185	COG0726	polysaccharide deacetylase
I3J17_RS16230	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS16295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J17_RS16310	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS16330	COG0259	pyridoxamine-phosphate oxidase activity
I3J17_RS16340	COG4821	SIS domain
I3J17_RS16350	COG0596	Alpha beta hydrolase
I3J17_RS16350	COG2945	thiolester hydrolase activity
I3J17_RS16420	COG3397	chitin binding
I3J17_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS16435	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS16440	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS16460	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS16470	COG1917	Cupin 2, conserved barrel domain protein
I3J17_RS16470	COG4977	sequence-specific DNA binding
I3J17_RS16475	COG2271	Major facilitator Superfamily
I3J17_RS16480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J17_RS16495	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J17_RS16500	COG2814	Major facilitator Superfamily
I3J17_RS16500	COG0477	Major facilitator Superfamily
I3J17_RS16505	COG0456	acetyltransferase
I3J17_RS16515	COG1024	Enoyl-CoA hydratase
I3J17_RS16525	COG2072	flavoprotein involved in K transport
I3J17_RS16540	COG0259	pyridoxamine-phosphate oxidase activity
I3J17_RS16565	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS16575	COG0702	epimerase
I3J17_RS16595	COG1309	transcriptional regulator
I3J17_RS16615	COG1725	Transcriptional regulator
I3J17_RS16690	COG1136	(ABC) transporter
I3J17_RS16715	COG0596	Alpha beta hydrolase
I3J17_RS16720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J17_RS16825	COG0113	porphobilinogen synthase activity
I3J17_RS16845	COG0018	arginyl-trna synthetase
I3J17_RS16850	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I3J17_RS16865	COG0626	cystathionine gamma-synthase activity
I3J17_RS16870	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3J17_RS16910	COG1690	Belongs to the RtcB family
I3J17_RS16915	COG0402	S-adenosylhomocysteine deaminase activity
I3J17_RS16930	COG1742	UPF0060 membrane protein
I3J17_RS16940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J17_RS16955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J17_RS16960	COG0406	alpha-ribazole phosphatase activity
I3J17_RS16965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J17_RS16970	COG0785	Cytochrome C biogenesis protein
I3J17_RS16975	COG1333	cytochrome c biogenesis protein
I3J17_RS16980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J17_RS16990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J17_RS16995	COG0109	protoheme IX farnesyltransferase activity
I3J17_RS17000	COG0163	prenyltransferase activity
I3J17_RS17010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J17_RS17030	COG1823	symporter activity
I3J17_RS17035	COG1278	Cold shock
I3J17_RS17040	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
I3J17_RS17045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I3J17_RS17055	COG2226	methyltransferase
I3J17_RS17085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17095	COG0649	NAD binding
I3J17_RS17105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3J17_RS17110	COG1034	ATP synthesis coupled electron transport
I3J17_RS17115	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J17_RS17120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17125	COG0839	Belongs to the complex I subunit 6 family
I3J17_RS17130	COG0713	ATP synthesis coupled electron transport
I3J17_RS17135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J17_RS17145	COG1007	ATP synthesis coupled electron transport
I3J17_RS17150	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J17_RS17155	COG2936	dipeptidyl-peptidase activity
I3J17_RS17160	COG0142	geranyltranstransferase activity
I3J17_RS17185	COG2234	aminopeptidase activity
I3J17_RS17185	COG4935	Belongs to the peptidase S8 family
I3J17_RS17200	COG1733	regulation of RNA biosynthetic process
I3J17_RS17225	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3J17_RS17230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3J17_RS17230	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3J17_RS17245	COG4585	Histidine kinase
I3J17_RS17250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17260	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3J17_RS17270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3J17_RS17275	COG0839	Belongs to the complex I subunit 6 family
I3J17_RS17280	COG0713	ATP synthesis coupled electron transport
I3J17_RS17295	COG1007	ATP synthesis coupled electron transport
I3J17_RS17300	COG0501	Belongs to the peptidase M48B family
I3J17_RS17305	COG3304	Inner membrane component domain
I3J17_RS17315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J17_RS17320	COG1666	GTP binding
I3J17_RS17340	COG0702	epimerase
I3J17_RS17360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I3J17_RS17365	COG2030	dehydratase
I3J17_RS17375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3J17_RS17380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J17_RS17385	COG0436	Aminotransferase
I3J17_RS17395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J17_RS17405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I3J17_RS17410	COG0081	regulation of translation
I3J17_RS17415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I3J17_RS17420	COG0222	ribosome binding
I3J17_RS17425	COG0085	RNA polymerase activity
I3J17_RS17430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I3J17_RS17435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3J17_RS17440	COG0049	tRNA binding
I3J17_RS17445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3J17_RS17450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I3J17_RS17460	COG0051	transcription antitermination factor activity, RNA binding
I3J17_RS17465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3J17_RS17470	COG0088	Forms part of the polypeptide exit tunnel
I3J17_RS17475	COG0089	rRNA binding
I3J17_RS17480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I3J17_RS17485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I3J17_RS17490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I3J17_RS17495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I3J17_RS17500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I3J17_RS17505	COG0255	Belongs to the universal ribosomal protein uL29 family
I3J17_RS17510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3J17_RS17515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I3J17_RS17520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I3J17_RS17525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I3J17_RS17530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I3J17_RS17535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3J17_RS17540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I3J17_RS17545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3J17_RS17550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I3J17_RS17555	COG1841	ribosomal large subunit assembly
I3J17_RS17560	COG0200	Binds to the 23S rRNA
I3J17_RS17570	COG0563	adenylate kinase activity
I3J17_RS17580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3J17_RS17585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J17_RS17590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I3J17_RS17595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I3J17_RS17600	COG0202	RNA polymerase activity
I3J17_RS17605	COG0203	ribosomal protein L17
I3J17_RS17610	COG0101	tRNA pseudouridine synthase activity
I3J17_RS17620	COG0488	(ABC) transporter
I3J17_RS17625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I3J17_RS17630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3J17_RS17635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J17_RS17640	COG1072	(Pantothenic acid kinase))
I3J17_RS17645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J17_RS17650	COG0736	holo-[acyl-carrier-protein] synthase activity
I3J17_RS17670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J17_RS17680	COG0802	atpase or kinase
I3J17_RS17705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J17_RS17730	COG4941	Belongs to the sigma-70 factor family
I3J17_RS17740	COG0726	polysaccharide deacetylase
I3J17_RS17745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3J17_RS17750	COG0459	protein refolding
I3J17_RS17755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J17_RS17770	COG0583	DNA-binding transcription factor activity
I3J17_RS17780	COG2197	response regulator
I3J17_RS17785	COG1595	DNA-templated transcription, initiation
I3J17_RS17795	COG0516	GMP reductase activity
I3J17_RS17805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J17_RS17825	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS17845	COG0519	Catalyzes the synthesis of GMP from XMP
I3J17_RS17845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3J17_RS17870	COG2197	response regulator
I3J17_RS17890	COG0739	heme binding
I3J17_RS17900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS17900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS17915	COG0714	Associated with various cellular activities
I3J17_RS17925	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3J17_RS17930	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J17_RS17960	COG0138	bifunctional purine biosynthesis protein purh
I3J17_RS17975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I3J17_RS17990	COG0039	L-malate dehydrogenase activity
I3J17_RS18000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J17_RS18040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J17_RS18050	COG0754	glutathionylspermidine amidase activity
I3J17_RS18055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J17_RS18060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J17_RS18065	COG0180	Tryptophanyl-tRNA synthetase
I3J17_RS18090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J17_RS18095	COG1295	ribonuclease BN
I3J17_RS18100	COG1686	Belongs to the peptidase S11 family
I3J17_RS18110	COG1408	metallophosphoesterase
I3J17_RS18120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J17_RS18125	COG1053	succinate dehydrogenase
I3J17_RS18135	COG2009	succinate dehydrogenase
I3J17_RS18140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I3J17_RS18150	COG1595	DNA-templated transcription, initiation
I3J17_RS18165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS18165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS18180	COG0516	GMP reductase activity
I3J17_RS18180	COG0517	IMP dehydrogenase activity
I3J17_RS18195	COG1216	Glycosyl transferase, family 2
I3J17_RS18205	COG1083	cytidylyl-transferase
I3J17_RS18210	COG2089	acid synthase
I3J17_RS18220	COG1473	amidohydrolase
I3J17_RS18220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3J17_RS18225	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J17_RS18230	COG3845	ABC transporter
I3J17_RS18235	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J17_RS18240	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J17_RS18275	COG2814	Major facilitator Superfamily
I3J17_RS18280	COG0583	DNA-binding transcription factor activity
I3J17_RS18295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J17_RS18320	COG2205	protein histidine kinase activity
I3J17_RS18325	COG0745	RESPONSE REGULATOR receiver
I3J17_RS18330	COG1595	DNA-templated transcription, initiation
I3J17_RS18345	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS18350	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS18380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J17_RS18410	COG4770	biotin carboxylase activity
I3J17_RS18415	COG0424	maF-like protein
I3J17_RS18425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J17_RS18440	COG1024	Enoyl-CoA hydratase
I3J17_RS18450	COG2986	histidine ammonia-lyase
I3J17_RS18465	COG1064	alcohol dehydrogenase
I3J17_RS18485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J17_RS18525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J17_RS18545	COG2188	Transcriptional regulator
I3J17_RS18555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3J17_RS18565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J17_RS18595	COG1331	Highly conserved protein containing a thioredoxin domain
I3J17_RS18600	COG1309	transcriptional regulator
I3J17_RS18610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3J17_RS18650	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS18655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J17_RS18665	COG0728	peptidoglycan biosynthetic process
I3J17_RS18700	COG0492	ferredoxin-NADP+ reductase activity
I3J17_RS18760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I3J17_RS18775	COG1414	Transcriptional regulator
I3J17_RS18780	COG0251	oxidation-reduction process
I3J17_RS18785	COG2610	gluconate transmembrane transporter activity
I3J17_RS18810	COG2894	cell division
I3J17_RS18840	COG4585	Histidine kinase
I3J17_RS18845	COG2197	response regulator
I3J17_RS18865	COG2885	chlorophyll binding
I3J17_RS18890	COG0667	Aldo Keto reductase
I3J17_RS18895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J17_RS18900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J17_RS18915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J17_RS18920	COG0450	alkyl hydroperoxide reductase
I3J17_RS18935	COG1136	(ABC) transporter
I3J17_RS18955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J17_RS18975	COG0114	fumarate hydratase activity
I3J17_RS18985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J17_RS18985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3J17_RS19010	COG0778	Nitroreductase
I3J17_RS19015	COG1722	exodeoxyribonuclease VII activity
I3J17_RS19020	COG1570	exodeoxyribonuclease VII activity
I3J17_RS19025	COG0531	amino acid
I3J17_RS19030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3J17_RS19045	COG0012	GTP binding
I3J17_RS19095	COG1053	succinate dehydrogenase
I3J17_RS19115	COG1217	gtp-binding protein TYPA
I3J17_RS19120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS19125	COG4166	transmembrane transport
I3J17_RS19135	COG0444	Belongs to the ABC transporter superfamily
I3J17_RS19140	COG4608	Belongs to the ABC transporter superfamily
I3J17_RS19155	COG0601	transmembrane transport
I3J17_RS19160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS19165	COG0444	Belongs to the ABC transporter superfamily
I3J17_RS19170	COG4608	Belongs to the ABC transporter superfamily
I3J17_RS19185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J17_RS19225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J17_RS19230	COG1611	Belongs to the LOG family
I3J17_RS19235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J17_RS19245	COG0519	Catalyzes the synthesis of GMP from XMP
I3J17_RS19250	COG1024	Enoyl-CoA hydratase
I3J17_RS19265	COG1595	DNA-templated transcription, initiation
I3J17_RS19275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J17_RS19280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J17_RS19315	COG0598	Magnesium transport protein CorA
I3J17_RS19335	COG2095	MarC family integral membrane protein
I3J17_RS19345	COG1432	Conserved Protein
I3J17_RS19370	COG0513	Belongs to the DEAD box helicase family
I3J17_RS19400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J17_RS19400	COG0596	Alpha beta hydrolase
I3J17_RS19410	COG0747	negative chemotaxis
I3J17_RS19415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS19420	COG0601	transmembrane transport
I3J17_RS19475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J17_RS19515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J17_RS19555	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J17_RS19565	COG1615	UPF0182 protein
I3J17_RS19590	COG0753	catalase activity
I3J17_RS19600	COG0483	inositol monophosphate 1-phosphatase activity
I3J17_RS19610	COG2076	Multidrug Resistance protein
I3J17_RS19620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3J17_RS19630	COG2135	peptidase activity
I3J17_RS19640	COG1595	DNA-templated transcription, initiation
I3J17_RS19645	COG5662	AntiSigma factor
I3J17_RS19665	COG0242	peptide deformylase activity
I3J17_RS19690	COG2188	Transcriptional regulator
I3J17_RS19695	COG2182	Extracellular solute-binding protein
I3J17_RS19700	COG1175	transmembrane transport
I3J17_RS19705	COG0395	ABC-type sugar transport system, permease component
I3J17_RS19710	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J17_RS19715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3J17_RS19730	COG1597	lipid kinase activity
I3J17_RS19765	COG0142	geranyltranstransferase activity
I3J17_RS19785	COG5640	endopeptidase activity
I3J17_RS19795	COG0494	nUDIX hydrolase
I3J17_RS19815	COG4106	trans-aconitate 2-methyltransferase activity
I3J17_RS19820	COG1126	abc transporter atp-binding protein
I3J17_RS19840	COG0604	alcohol dehydrogenase
I3J17_RS19875	COG2255	four-way junction helicase activity
I3J17_RS19885	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J17_RS19885	COG0567	Dehydrogenase, E1 component
I3J17_RS19890	COG2205	protein histidine kinase activity
I3J17_RS19895	COG0745	RESPONSE REGULATOR receiver
I3J17_RS19905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J17_RS19910	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J17_RS19930	COG2205	protein histidine kinase activity
I3J17_RS19965	COG2318	DinB family
I3J17_RS19995	COG0768	penicillin binding
I3J17_RS20050	COG1793	dna ligase
I3J17_RS20055	COG1793	dna ligase
I3J17_RS20055	COG3285	dna ligase
I3J17_RS20060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J17_RS20065	COG2072	flavoprotein involved in K transport
I3J17_RS20085	COG0745	RESPONSE REGULATOR receiver
I3J17_RS20090	COG2205	protein histidine kinase activity
I3J17_RS20100	COG2124	cytochrome p450
I3J17_RS20105	COG0768	penicillin binding
I3J17_RS20110	COG0768	penicillin binding
I3J17_RS20115	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J17_RS20125	COG0747	negative chemotaxis
I3J17_RS20130	COG0456	acetyltransferase
I3J17_RS20135	COG0697	spore germination
I3J17_RS20175	COG2175	clavaminate synthase activity
I3J17_RS20180	COG0010	Belongs to the arginase family
I3J17_RS20185	COG0367	asparagine synthase
I3J17_RS20195	COG0768	penicillin binding
I3J17_RS20205	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J17_RS20215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J17_RS20225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J17_RS20235	COG2192	nodulation
I3J17_RS20255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J17_RS20260	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I3J17_RS20265	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS20275	COG1686	Belongs to the peptidase S11 family
I3J17_RS20280	COG2367	Beta-lactamase
I3J17_RS20420	COG0018	arginyl-trna synthetase
I3J17_RS20425	COG0019	diaminopimelate decarboxylase activity
I3J17_RS20430	COG0460	homoserine dehydrogenase
I3J17_RS20435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J17_RS20440	COG0083	homoserine kinase activity
I3J17_RS20455	COG1316	TRANSCRIPTIONal
I3J17_RS20460	COG0254	rRNA binding
I3J17_RS20465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J17_RS20470	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J17_RS20480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J17_RS20485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J17_RS20505	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J17_RS20510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I3J17_RS20515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3J17_RS20520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I3J17_RS20525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I3J17_RS20530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3J17_RS20535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3J17_RS20550	COG0494	nUDIX hydrolase
I3J17_RS20560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J17_RS20590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J17_RS20610	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J17_RS20620	COG2197	response regulator
I3J17_RS20625	COG4585	Histidine kinase
I3J17_RS20640	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J17_RS20655	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I3J17_RS20690	COG1131	(ABC) transporter
I3J17_RS20710	COG0183	Belongs to the thiolase family
I3J17_RS20725	COG0745	RESPONSE REGULATOR receiver
I3J17_RS20770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS20770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS20805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3J17_RS20810	COG0280	phosphate acetyltransferase
I3J17_RS20810	COG0857	belongs to the CobB CobQ family
I3J17_RS20815	COG0205	6-phosphofructokinase activity
I3J17_RS20825	COG1175	transmembrane transport
I3J17_RS20855	COG0181	hydroxymethylbilane synthase activity
I3J17_RS20860	COG4565	transcriptional regulatory protein
I3J17_RS20865	COG3290	protein histidine kinase activity
I3J17_RS20870	COG1301	dicarboxylic acid transport
I3J17_RS20885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3J17_RS20895	COG0366	Alpha amylase catalytic
I3J17_RS20900	COG0366	Alpha amylase catalytic
I3J17_RS20905	COG0058	SHG alpha-glucan phosphorylase activity
I3J17_RS20915	COG4585	Histidine kinase
I3J17_RS20920	COG2197	response regulator
I3J17_RS20955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J17_RS20965	COG1132	(ABC) transporter
I3J17_RS20970	COG1132	(ABC) transporter
I3J17_RS20985	COG1024	Enoyl-CoA hydratase
I3J17_RS21115	COG2856	Zn peptidase
I3J17_RS21125	COG1760	l-serine dehydratase
I3J17_RS21130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3J17_RS21135	COG0509	glycine decarboxylation via glycine cleavage system
I3J17_RS21140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I3J17_RS21160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS21165	COG0747	negative chemotaxis
I3J17_RS21170	COG0601	transmembrane transport
I3J17_RS21175	COG0444	Belongs to the ABC transporter superfamily
I3J17_RS21180	COG4608	Belongs to the ABC transporter superfamily
I3J17_RS21185	COG2860	membrane
I3J17_RS21210	COG0482	sulfurtransferase activity
I3J17_RS21220	COG1611	Belongs to the LOG family
I3J17_RS21225	COG4221	oxidoreductase activity
I3J17_RS21235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I3J17_RS21245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J17_RS21250	COG0154	amidase activity
I3J17_RS21260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3J17_RS21270	COG2409	Drug exporters of the RND superfamily
I3J17_RS21275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J17_RS21290	COG1672	PFAM Archaeal ATPase
I3J17_RS21290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3J17_RS21300	COG2133	pyrroloquinoline quinone binding
I3J17_RS21305	COG0667	Aldo Keto reductase
I3J17_RS21325	COG0440	acetolactate synthase activity
I3J17_RS21330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I3J17_RS21335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J17_RS21340	COG2508	Transcriptional regulator
I3J17_RS21340	COG2508	Transcriptional regulator
I3J17_RS21345	COG0506	proline dehydrogenase activity
I3J17_RS21350	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS21355	COG0640	Transcriptional regulator
I3J17_RS21415	COG1082	Xylose isomerase domain protein TIM barrel
I3J17_RS21430	COG0473	3-isopropylmalate dehydrogenase activity
I3J17_RS21435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J17_RS21450	COG3321	synthase
I3J17_RS21450	COG0604	alcohol dehydrogenase
I3J17_RS21460	COG0300	oxidoreductase activity
I3J17_RS21485	COG0831	urea catabolic process
I3J17_RS21485	COG0832	Belongs to the urease beta subunit family
I3J17_RS21495	COG0804	urea catabolic process
I3J17_RS21500	COG2957	Belongs to the agmatine deiminase family
I3J17_RS21510	COG0477	Major facilitator Superfamily
I3J17_RS21515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J17_RS21525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J17_RS21545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J17_RS21565	COG2018	Roadblock/LC7 domain
I3J17_RS21585	COG2018	Roadblock/LC7 domain
I3J17_RS21590	COG5002	protein histidine kinase activity
I3J17_RS21600	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J17_RS21605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3J17_RS21610	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I3J17_RS21640	COG1414	Transcriptional regulator
I3J17_RS21645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I3J17_RS21650	COG0066	3-isopropylmalate dehydratase activity
I3J17_RS21660	COG0776	regulation of translation
I3J17_RS21670	COG1920	GTP binding
I3J17_RS21680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J17_RS21685	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3J17_RS21700	COG0351	phosphomethylpyrimidine kinase
I3J17_RS21705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I3J17_RS21710	COG1461	Dihydroxyacetone kinase
I3J17_RS21720	COG0742	ribosomal rna small subunit methyltransferase
I3J17_RS21725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I3J17_RS21740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I3J17_RS21745	COG0571	ribonuclease III activity
I3J17_RS21750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J17_RS21755	COG2340	Cysteine-rich secretory protein family
I3J17_RS21760	COG1254	Belongs to the acylphosphatase family
I3J17_RS21775	COG1196	nuclear chromosome segregation
I3J17_RS21780	COG0477	Major facilitator Superfamily
I3J17_RS21785	COG4552	Acetyltransferase involved in intracellular survival and related
I3J17_RS21815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3J17_RS21825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J17_RS21835	COG0228	four-way junction DNA binding
I3J17_RS21840	COG1837	Belongs to the UPF0109 family
I3J17_RS21845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I3J17_RS21850	COG0336	Belongs to the RNA methyltransferase TrmD family
I3J17_RS21855	COG0335	large ribosomal subunit rRNA binding
I3J17_RS21860	COG0681	Belongs to the peptidase S26 family
I3J17_RS21875	COG0681	Belongs to the peptidase S26 family
I3J17_RS21885	COG0792	nuclease activity
I3J17_RS21900	COG1191	sigma factor activity
I3J17_RS21915	COG0052	Belongs to the universal ribosomal protein uS2 family
I3J17_RS21920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I3J17_RS21925	COG0528	UMP kinase activity
I3J17_RS21930	COG0233	cytoplasmic translational termination
I3J17_RS21935	COG0575	Belongs to the CDS family
I3J17_RS21940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3J17_RS21955	COG3842	ATPase activity
I3J17_RS21970	COG1136	(ABC) transporter
I3J17_RS21975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS21985	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS22000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J17_RS22025	COG3842	ATPase activity
I3J17_RS22030	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3J17_RS22035	COG1177	transmembrane transport
I3J17_RS22040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J17_RS22070	COG2508	Transcriptional regulator
I3J17_RS22085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3J17_RS22090	COG0750	zinc metalloprotease
I3J17_RS22095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I3J17_RS22110	COG0442	prolyl-tRNA aminoacylation
I3J17_RS22130	COG0779	Required for maturation of 30S ribosomal subunits
I3J17_RS22145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I3J17_RS22155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I3J17_RS22160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I3J17_RS22180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS22185	COG0601	transmembrane transport
I3J17_RS22190	COG0747	negative chemotaxis
I3J17_RS22195	COG0455	bacterial-type flagellum organization
I3J17_RS22215	COG3266	domain, Protein
I3J17_RS22220	COG1404	Belongs to the peptidase S8 family
I3J17_RS22235	COG1404	Belongs to the peptidase S8 family
I3J17_RS22250	COG1674	ftsk spoiiie
I3J17_RS22260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I3J17_RS22265	COG1185	polyribonucleotide nucleotidyltransferase activity
I3J17_RS22270	COG0612	Peptidase, M16
I3J17_RS22275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3J17_RS22295	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I3J17_RS22300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J17_RS22305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J17_RS22330	COG2770	Histidine kinase
I3J17_RS22330	COG2208	phosphoserine phosphatase activity
I3J17_RS22335	COG5002	protein histidine kinase activity
I3J17_RS22335	COG0784	Response regulator, receiver
I3J17_RS22345	COG1674	ftsk spoiiie
I3J17_RS22355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J17_RS22365	COG1546	Belongs to the CinA family
I3J17_RS22365	COG1058	Belongs to the CinA family
I3J17_RS22370	COG1396	sequence-specific DNA binding
I3J17_RS22375	COG0783	Belongs to the Dps family
I3J17_RS22380	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS22385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J17_RS22390	COG1201	RNA secondary structure unwinding
I3J17_RS22430	COG2137	regulation of response to DNA damage stimulus
I3J17_RS22445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J17_RS22450	COG0765	amino acid transport
I3J17_RS22455	COG0765	amino acid transport
I3J17_RS22460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J17_RS22465	COG1126	abc transporter atp-binding protein
I3J17_RS22470	COG0745	RESPONSE REGULATOR receiver
I3J17_RS22475	COG2205	protein histidine kinase activity
I3J17_RS22480	COG2358	TRAP transporter, solute receptor (TAXI family
I3J17_RS22485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J17_RS22505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I3J17_RS22515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3J17_RS22520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J17_RS22530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J17_RS22560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3J17_RS22565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3J17_RS22570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J17_RS22595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3J17_RS22625	COG1131	(ABC) transporter
I3J17_RS22630	COG2186	Transcriptional regulator
I3J17_RS22635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J17_RS22650	COG0187	DNA topoisomerase II activity
I3J17_RS22655	COG4565	transcriptional regulatory protein
I3J17_RS22660	COG3290	protein histidine kinase activity
I3J17_RS22670	COG0372	Belongs to the citrate synthase family
I3J17_RS22680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J17_RS22685	COG0612	Peptidase, M16
I3J17_RS22695	COG0739	heme binding
I3J17_RS22695	COG0741	lytic transglycosylase activity
I3J17_RS22695	COG1196	nuclear chromosome segregation
I3J17_RS22700	COG1802	Transcriptional regulator
I3J17_RS22705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J17_RS22710	COG0045	succinate-CoA ligase (ADP-forming) activity
I3J17_RS22710	COG1042	CoA-binding domain protein
I3J17_RS22710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J17_RS22725	COG1435	thymidine kinase activity
I3J17_RS22740	COG0702	epimerase
I3J17_RS22750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J17_RS22765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J17_RS22770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J17_RS22775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3J17_RS22835	COG2264	protein methyltransferase activity
I3J17_RS22845	COG3903	Transcriptional regulator
I3J17_RS22845	COG3629	intracellular signal transduction
I3J17_RS22865	COG2409	Drug exporters of the RND superfamily
I3J17_RS22920	COG0142	geranyltranstransferase activity
I3J17_RS22950	COG0494	nUDIX hydrolase
I3J17_RS22965	COG2264	protein methyltransferase activity
I3J17_RS22970	COG0483	inositol monophosphate 1-phosphatase activity
I3J17_RS22980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J17_RS22985	COG0531	amino acid
I3J17_RS22990	COG0569	domain protein
I3J17_RS23000	COG1136	(ABC) transporter
I3J17_RS23000	COG0577	efflux transmembrane transporter activity
I3J17_RS23035	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3J17_RS23035	COG1136	(ABC) transporter
I3J17_RS23045	COG0756	dUTP diphosphatase activity
I3J17_RS23070	COG2205	protein histidine kinase activity
I3J17_RS23075	COG0745	RESPONSE REGULATOR receiver
I3J17_RS23090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J17_RS23120	COG4689	acetoacetate decarboxylase
I3J17_RS23140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J17_RS23160	COG1799	cell septum assembly
I3J17_RS23180	COG2040	homocysteine
I3J17_RS23200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3J17_RS23210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J17_RS23215	COG1024	Enoyl-CoA hydratase
I3J17_RS23260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J17_RS23280	COG1522	sequence-specific DNA binding
I3J17_RS23285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J17_RS23295	COG1653	transport
I3J17_RS23300	COG1175	transmembrane transport
I3J17_RS23305	COG0395	ABC-type sugar transport system, permease component
I3J17_RS23310	COG1940	carbohydrate kinase activity
I3J17_RS23315	COG4213	ABC transporter substrate-binding protein
I3J17_RS23325	COG4214	carbohydrate transport
I3J17_RS23330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3J17_RS23335	COG0531	amino acid
I3J17_RS23345	COG1024	Enoyl-CoA hydratase
I3J17_RS23345	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J17_RS23350	COG0183	Belongs to the thiolase family
I3J17_RS23370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3J17_RS23375	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3J17_RS23385	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J17_RS23390	COG3253	May function as heme-dependent peroxidase
I3J17_RS23395	COG0596	Alpha beta hydrolase
I3J17_RS23410	COG3220	belongs to the UPF0276 family
I3J17_RS23430	COG1846	Transcriptional regulator
I3J17_RS23435	COG1764	response to oxidative stress
I3J17_RS23460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3J17_RS23465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3J17_RS23540	COG1175	transmembrane transport
I3J17_RS23575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J17_RS23580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3J17_RS23600	COG0529	Catalyzes the synthesis of activated sulfate
I3J17_RS23605	COG0175	sulfate reduction
I3J17_RS23625	COG3284	Transcriptional regulator
I3J17_RS23630	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS23670	COG3290	protein histidine kinase activity
I3J17_RS23700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J17_RS23725	COG1162	GTPase activity
I3J17_RS23755	COG0028	Belongs to the TPP enzyme family
I3J17_RS23775	COG1802	Transcriptional regulator
I3J17_RS23790	COG3842	ATPase activity
I3J17_RS23800	COG1840	ABC-type Fe3 transport system, periplasmic component
I3J17_RS23805	COG3835	regulator
I3J17_RS23820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3J17_RS23865	COG1609	Transcriptional regulator
I3J17_RS23875	COG0515	serine threonine protein kinase
I3J17_RS23885	COG1132	(ABC) transporter
I3J17_RS23890	COG1132	(ABC) transporter
I3J17_RS23895	COG2197	response regulator
I3J17_RS23910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS23925	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS23930	COG2345	Transcriptional regulator
I3J17_RS23945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J17_RS23980	COG0243	molybdopterin cofactor binding
I3J17_RS23995	COG1404	Belongs to the peptidase S8 family
I3J17_RS24015	COG3409	Peptidoglycan-binding domain 1 protein
I3J17_RS24030	COG2197	response regulator
I3J17_RS24035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J17_RS24040	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS24065	COG2351	hydroxyisourate hydrolase activity
I3J17_RS24095	COG1288	antiporter activity
I3J17_RS24110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J17_RS24120	COG0746	molybdenum cofactor guanylyltransferase activity
I3J17_RS24135	COG1414	Transcriptional regulator
I3J17_RS24140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J17_RS24145	COG4266	Belongs to the allantoicase family
I3J17_RS24160	COG4585	Histidine kinase
I3J17_RS24165	COG2197	response regulator
I3J17_RS24175	COG0673	inositol 2-dehydrogenase activity
I3J17_RS24180	COG2188	Transcriptional regulator
I3J17_RS24200	COG1940	carbohydrate kinase activity
I3J17_RS24210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J17_RS24230	COG1126	abc transporter atp-binding protein
I3J17_RS24235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J17_RS24240	COG0765	amino acid transport
I3J17_RS24245	COG0765	amino acid transport
I3J17_RS24255	COG0405	Gamma-glutamyltransferase
I3J17_RS24285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J17_RS24290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J17_RS24300	COG0095	Lipoate-protein ligase
I3J17_RS24305	COG0483	inositol monophosphate 1-phosphatase activity
I3J17_RS24320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3J17_RS24330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J17_RS24335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J17_RS24350	COG1929	Belongs to the glycerate kinase type-1 family
I3J17_RS24360	COG0688	phosphatidylethanolamine metabolic process
I3J17_RS24365	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS24380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS24380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3J17_RS24385	COG0604	alcohol dehydrogenase
I3J17_RS24440	COG2362	D-Aminopeptidase
I3J17_RS24445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J17_RS24455	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J17_RS24460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I3J17_RS24530	COG1063	alcohol dehydrogenase
I3J17_RS24580	COG1793	dna ligase
I3J17_RS24590	COG0656	L-ascorbic acid biosynthetic process
I3J17_RS24600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J17_RS24605	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I3J17_RS24620	COG3250	beta-galactosidase activity
I3J17_RS24630	COG3250	beta-galactosidase activity
I3J17_RS24640	COG1595	DNA-templated transcription, initiation
I3J17_RS24660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J17_RS24665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J17_RS24675	COG1940	carbohydrate kinase activity
I3J17_RS24680	COG1129	ABC transporter
I3J17_RS24685	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J17_RS24690	COG4213	ABC transporter substrate-binding protein
I3J17_RS24695	COG0673	inositol 2-dehydrogenase activity
I3J17_RS24715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3J17_RS24720	COG1082	Xylose isomerase domain protein TIM barrel
I3J17_RS24810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J17_RS24815	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J17_RS24820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J17_RS24835	COG0475	glutathione-regulated potassium exporter activity
I3J17_RS24925	COG3345	alpha-galactosidase
I3J17_RS24930	COG1609	Transcriptional regulator
I3J17_RS24960	COG3012	SEC-C Motif Domain Protein
I3J17_RS25000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3J17_RS25055	COG1793	dna ligase
I3J17_RS25095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J17_RS25100	COG0488	(ABC) transporter
I3J17_RS25115	COG1515	deoxyribonuclease V activity
I3J17_RS25120	COG3268	Saccharopine dehydrogenase
I3J17_RS25125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3J17_RS25130	COG0183	Belongs to the thiolase family
I3J17_RS25135	COG1024	Enoyl-CoA hydratase
I3J17_RS25135	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J17_RS25155	COG2936	dipeptidyl-peptidase activity
I3J17_RS25165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J17_RS25180	COG2183	response to ionizing radiation
I3J17_RS25210	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J17_RS25235	COG0371	Dehydrogenase
I3J17_RS25250	COG1134	teichoic acid transport
I3J17_RS25255	COG1562	ergosterol biosynthetic process
I3J17_RS25265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J17_RS25275	COG1657	PFAM Prenyltransferase squalene oxidase
I3J17_RS25305	COG2365	Tyrosine phosphatase family
I3J17_RS25315	COG0739	heme binding
I3J17_RS25315	COG0741	lytic transglycosylase activity
I3J17_RS25315	COG1196	nuclear chromosome segregation
I3J17_RS25325	COG1309	transcriptional regulator
I3J17_RS25330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J17_RS25365	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS25370	COG4948	Mandelate Racemase Muconate Lactonizing
I3J17_RS25375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J17_RS25385	COG1116	anion transmembrane transporter activity
I3J17_RS25430	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS25520	COG3511	phospholipase C
I3J17_RS25580	COG2850	peptidyl-arginine hydroxylation
I3J17_RS25585	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS25630	COG0673	inositol 2-dehydrogenase activity
I3J17_RS25670	COG0187	DNA topoisomerase II activity
I3J17_RS25680	COG2226	methyltransferase
I3J17_RS25700	COG0477	Major facilitator Superfamily
I3J17_RS25750	COG4981	capsule polysaccharide biosynthetic process
I3J17_RS25755	COG0500	methyltransferase
I3J17_RS25790	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS25835	COG0247	lactate metabolic process
I3J17_RS25840	COG1139	Iron-sulfur cluster binding protein
I3J17_RS25845	COG1556	Lactate utilization protein
I3J17_RS25870	COG2072	flavoprotein involved in K transport
I3J17_RS25895	COG0842	Transport permease protein
I3J17_RS25895	COG1129	ABC transporter
I3J17_RS25900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J17_RS25955	COG0667	Aldo Keto reductase
I3J17_RS25965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J17_RS25970	COG3251	PFAM MbtH domain protein
I3J17_RS25985	COG2318	DinB family
I3J17_RS25995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J17_RS26000	COG1051	belongs to the nudix hydrolase family
I3J17_RS26015	COG0395	ABC-type sugar transport system, permease component
I3J17_RS26020	COG1175	transmembrane transport
I3J17_RS26065	COG0248	Ppx GppA phosphatase
I3J17_RS26085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I3J17_RS26115	COG0745	RESPONSE REGULATOR receiver
I3J17_RS26120	COG2205	protein histidine kinase activity
I3J17_RS26155	COG3845	ABC transporter
I3J17_RS26165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3J17_RS26175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J17_RS26195	COG0297	glycogen (starch) synthase activity
I3J17_RS26250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J17_RS26265	COG3279	Response regulator of the LytR AlgR family
I3J17_RS26280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J17_RS26285	COG3275	phosphorelay sensor kinase activity
I3J17_RS26330	COG5001	Diguanylate cyclase
I3J17_RS26330	COG3300	MHYT domain
I3J17_RS26350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J17_RS26360	COG3360	Dodecin
I3J17_RS26365	COG2182	Extracellular solute-binding protein
I3J17_RS26370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3J17_RS26375	COG0121	glutamine amidotransferase
I3J17_RS26380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J17_RS26385	COG3572	ergothioneine biosynthetic process
I3J17_RS26400	COG0596	Alpha beta hydrolase
I3J17_RS26405	COG1609	Transcriptional regulator
I3J17_RS26415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J17_RS26420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J17_RS26450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J17_RS26465	COG2205	protein histidine kinase activity
I3J17_RS26470	COG0745	RESPONSE REGULATOR receiver
I3J17_RS26485	COG2755	lipolytic protein G-D-S-L family
I3J17_RS26485	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J17_RS26505	COG0579	oxidoreductase
I3J17_RS26510	COG0477	Major facilitator Superfamily
I3J17_RS26515	COG0154	amidase activity
I3J17_RS26520	COG2197	response regulator
I3J17_RS26540	COG4552	Acetyltransferase involved in intracellular survival and related
I3J17_RS26555	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J17_RS26560	COG1120	ATPase activity
I3J17_RS26565	COG2207	Transcriptional regulator
I3J17_RS26580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS26590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J17_RS26600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3J17_RS26640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J17_RS26660	COG2957	Belongs to the agmatine deiminase family
I3J17_RS26695	COG1174	glycine betaine transport
I3J17_RS26700	COG1174	glycine betaine transport
I3J17_RS26720	COG0477	Major facilitator Superfamily
I3J17_RS26725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3J17_RS26765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J17_RS26765	COG0574	Belongs to the PEP-utilizing enzyme family
I3J17_RS26785	COG1597	lipid kinase activity
I3J17_RS26790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J17_RS26795	COG3903	Transcriptional regulator
I3J17_RS26795	COG3629	intracellular signal transduction
I3J17_RS26830	COG1309	transcriptional regulator
I3J17_RS26850	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS26880	COG1131	(ABC) transporter
I3J17_RS26965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3J17_RS26970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J17_RS27005	COG3959	Transketolase, thiamine diphosphate binding domain
I3J17_RS27015	COG3424	synthase
I3J17_RS27025	COG0535	radical SAM domain protein
I3J17_RS27045	COG1376	ErfK ybiS ycfS ynhG family protein
I3J17_RS27050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J17_RS27070	COG0183	Belongs to the thiolase family
I3J17_RS27120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3J17_RS27125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3J17_RS27130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I3J17_RS27180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J17_RS27185	COG2326	polyphosphate kinase activity
I3J17_RS27215	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS27235	COG1413	lyase activity
I3J17_RS27255	COG0402	S-adenosylhomocysteine deaminase activity
I3J17_RS27270	COG0463	Glycosyl transferase, family 2
I3J17_RS27305	COG2124	cytochrome p450
I3J17_RS27330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I3J17_RS27330	COG1024	Enoyl-CoA hydratase
I3J17_RS27350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3J17_RS27375	COG2124	cytochrome p450
I3J17_RS27390	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J17_RS27410	COG1309	transcriptional regulator
I3J17_RS27420	COG1174	glycine betaine transport
I3J17_RS27425	COG1174	glycine betaine transport
I3J17_RS27440	COG3458	cephalosporin-C deacetylase activity
I3J17_RS27445	COG1125	glycine betaine transport
I3J17_RS27445	COG0517	IMP dehydrogenase activity
I3J17_RS27475	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS27480	COG1960	acyl-CoA dehydrogenase activity
I3J17_RS27490	COG0601	transmembrane transport
I3J17_RS27495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J17_RS27500	COG0444	Belongs to the ABC transporter superfamily
I3J17_RS27505	COG1124	(ABC) transporter
I3J17_RS27545	COG2124	cytochrome p450
I3J17_RS27550	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS27600	COG2376	Dihydroxyacetone kinase
I3J17_RS27605	COG2376	Dihydroxyacetone kinase
I3J17_RS27610	COG2130	NADP-dependent
I3J17_RS27615	COG1233	COG1233 Phytoene dehydrogenase and related
I3J17_RS27640	COG1233	COG1233 Phytoene dehydrogenase and related
I3J17_RS27645	COG1653	transport
I3J17_RS27660	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J17_RS27660	COG2172	sigma factor antagonist activity
I3J17_RS27660	COG2208	phosphoserine phosphatase activity
I3J17_RS27665	COG0542	response to heat
I3J17_RS27680	COG1846	Transcriptional regulator
I3J17_RS27725	COG0473	3-isopropylmalate dehydrogenase activity
I3J17_RS27760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J17_RS27765	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS27800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J17_RS27800	COG0438	transferase activity, transferring glycosyl groups
I3J17_RS27810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J17_RS27825	COG4310	Domain of unknown function (DUF2172)
I3J17_RS27835	COG1215	transferase activity, transferring glycosyl groups
I3J17_RS27850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I3J17_RS27880	COG2124	cytochrome p450
I3J17_RS27895	COG0142	geranyltranstransferase activity
I3J17_RS27900	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS27915	COG1012	belongs to the aldehyde dehydrogenase family
I3J17_RS27935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J17_RS27950	COG2018	Roadblock/LC7 domain
I3J17_RS27960	COG0156	8-amino-7-oxononanoate synthase activity
I3J17_RS27965	COG1063	alcohol dehydrogenase
I3J17_RS27990	COG2814	Major facilitator Superfamily
I3J17_RS28015	COG0475	glutathione-regulated potassium exporter activity
I3J17_RS28015	COG0569	domain protein
I3J17_RS28040	COG0019	diaminopimelate decarboxylase activity
I3J17_RS28065	COG1966	Carbon starvation protein
I3J17_RS28230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J17_RS28275	COG1121	(ABC) transporter
I3J17_RS28280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3J17_RS28300	COG0076	glutamate decarboxylase activity
I3J17_RS28315	COG1125	glycine betaine transport
I3J17_RS28315	COG0517	IMP dehydrogenase activity
I3J17_RS28320	COG1174	glycine betaine transport
I3J17_RS28325	COG1732	Glycine betaine
I3J17_RS28330	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
I3J17_RS28385	COG1228	amidohydrolase
I3J17_RS28390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J17_RS28400	COG2816	NAD+ diphosphatase activity
I3J17_RS28410	COG4552	Acetyltransferase involved in intracellular survival and related
I3J17_RS28420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J17_RS28445	COG1940	carbohydrate kinase activity
I3J17_RS28450	COG0363	glucosamine-6-phosphate deaminase activity
I3J17_RS28465	COG0546	phosphoglycolate phosphatase activity
I3J17_RS28505	COG0477	Major facilitator Superfamily
I3J17_RS28545	COG0110	maltose O-acetyltransferase activity
I3J17_RS28590	COG1024	Enoyl-CoA hydratase
I3J17_RS28620	COG0301	tRNA thio-modification
I3J17_RS28625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J17_RS28635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3J17_RS28655	COG0640	Transcriptional regulator
I3J17_RS28690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS28695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS28700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J17_RS28710	COG0431	NADPH-dependent FMN reductase
I3J17_RS28725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J17_RS28730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3J17_RS28760	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J17_RS28760	COG2319	Wd-40 repeat
I3J17_RS28855	COG2318	DinB family
I3J17_RS28905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J17_RS28930	COG1309	transcriptional regulator
I3J17_RS28940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3J17_RS28945	COG1725	Transcriptional regulator
I3J17_RS28970	COG3903	Transcriptional regulator
I3J17_RS28970	COG3629	intracellular signal transduction
I3J17_RS28985	COG0494	nUDIX hydrolase
I3J17_RS29025	COG3409	Peptidoglycan-binding domain 1 protein
I3J17_RS29040	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
I3J17_RS29055	COG2226	methyltransferase
I3J17_RS29090	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS29135	COG0477	Major facilitator Superfamily
I3J17_RS29215	COG2267	carboxylic ester hydrolase activity
I3J17_RS29225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3J17_RS29240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J17_RS29250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS29285	COG0698	ribose 5-phosphate isomerase
I3J17_RS29315	COG0488	(ABC) transporter
I3J17_RS29350	COG3757	hydrolase, family 25
I3J17_RS29350	COG3409	Peptidoglycan-binding domain 1 protein
I3J17_RS29370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J17_RS29385	COG2124	cytochrome p450
I3J17_RS29390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J17_RS29450	COG1132	(ABC) transporter
I3J17_RS29480	COG3397	chitin binding
I3J17_RS29490	COG0789	Transcriptional regulator
I3J17_RS29530	COG1011	Hydrolase
I3J17_RS29540	COG2124	cytochrome p450
I3J17_RS29585	COG1070	Carbohydrate kinase
I3J17_RS29590	COG0277	FAD linked oxidase domain protein
I3J17_RS29595	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS29600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J17_RS29635	COG3958	Transketolase
I3J17_RS29640	COG3959	Transketolase, thiamine diphosphate binding domain
I3J17_RS29795	COG1320	monovalent cation:proton antiporter activity
I3J17_RS29810	COG0651	ATP synthesis coupled electron transport
I3J17_RS29815	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J17_RS29820	COG2111	Na H antiporter
I3J17_RS29820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J17_RS29865	COG0583	DNA-binding transcription factor activity
I3J17_RS29880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3J17_RS29890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J17_RS29895	COG0436	Aminotransferase
I3J17_RS29915	COG0367	asparagine synthase
I3J17_RS29920	COG0010	Belongs to the arginase family
I3J17_RS29925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J17_RS29930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J17_RS29945	COG2201	protein-glutamate methylesterase activity
I3J17_RS29955	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS29980	COG2133	pyrroloquinoline quinone binding
I3J17_RS29980	COG5183	chlorophyll binding
I3J17_RS29985	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3J17_RS30015	COG3973	AAA domain
I3J17_RS30020	COG3409	Peptidoglycan-binding domain 1 protein
I3J17_RS30060	COG1335	isochorismatase
I3J17_RS30065	COG2319	Wd-40 repeat
I3J17_RS30065	COG4249	Peptidase C14 caspase catalytic subunit p20
I3J17_RS30100	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J17_RS30125	COG2124	cytochrome p450
I3J17_RS30235	COG1028	Short-chain dehydrogenase reductase Sdr
I3J17_RS30245	COG2124	cytochrome p450
I3J17_RS30280	COG4948	Mandelate Racemase Muconate Lactonizing
I3J17_RS30310	COG2205	protein histidine kinase activity
I3J17_RS30315	COG0745	RESPONSE REGULATOR receiver
I3J17_RS30330	COG1136	(ABC) transporter
I3J17_RS30330	COG0577	efflux transmembrane transporter activity
I3J17_RS30335	COG1136	(ABC) transporter
I3J17_RS30335	COG0577	efflux transmembrane transporter activity
I3J17_RS30385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J17_RS30395	COG2226	methyltransferase
I3J17_RS30405	COG0640	Transcriptional regulator
I3J17_RS30410	COG0346	lactoylglutathione lyase activity
I3J17_RS30415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J17_RS30420	COG2124	cytochrome p450
I3J17_RS30425	COG2124	cytochrome p450
I3J17_RS30430	COG1695	Transcriptional regulator
I3J17_RS30440	COG0436	Aminotransferase
I3J17_RS30445	COG0789	Transcriptional regulator
I3J17_RS30475	COG2124	cytochrome p450
I3J17_RS30550	COG3903	Transcriptional regulator
I3J17_RS30550	COG3629	intracellular signal transduction
I3J17_RS30560	COG1222	aaa ATPase
I3J17_RS30570	COG2197	response regulator
I3J17_RS30610	COG2304	oxidoreductase activity
I3J17_RS30625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I3J17_RS30635	COG0531	amino acid
I3J17_RS30670	COG0076	glutamate decarboxylase activity
I3J17_RS30690	COG2814	Major facilitator Superfamily
I3J17_RS30710	COG0604	alcohol dehydrogenase
I3J17_RS30710	COG3321	synthase
I3J17_RS30750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3J17_RS30765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J17_RS30770	COG2814	Major facilitator Superfamily
I3J17_RS30800	COG2197	response regulator
I3J17_RS30870	COG0318	PFAM AMP-dependent synthetase and ligase
I3J17_RS30875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3J17_RS30885	COG3547	Transposase (IS116 IS110 IS902 family)
I3J17_RS30930	COG2161	toxin-antitoxin pair type II binding
I3J17_RS30975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan