locus-tag	class	description
SCO0015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCO0037	COG1595	DNA-templated transcription, initiation
SCO0040	COG1819	glycosyl
SCO0046	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SCO0059	COG0604	alcohol dehydrogenase
SCO0062	COG1609	Transcriptional regulator
SCO0066	COG1175	transmembrane transport
SCO0067	COG0395	ABC-type sugar transport system, permease component
SCO0079	COG2814	Major facilitator Superfamily
SCO0087	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SCO0089	COG0583	DNA-binding transcription factor activity
SCO0091	COG3415	Transposase
SCO0091	COG2801	Transposase and inactivated derivatives
SCO0105	COG0726	polysaccharide deacetylase
SCO0106	COG3293	Transposase
SCO0111	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0118	COG3507	Belongs to the glycosyl hydrolase 43 family
SCO0121	COG1131	(ABC) transporter
SCO0122	COG2072	flavoprotein involved in K transport
SCO0125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SCO0125	COG2070	2-Nitropropane dioxygenase
SCO0126	COG0604	alcohol dehydrogenase
SCO0126	COG3321	synthase
SCO0130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCO0143	COG1309	transcriptional regulator
SCO0146	COG3547	Transposase (IS116 IS110 IS902 family)
SCO0148	COG3655	Transcriptional regulator
SCO0152	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCO0159	COG1595	DNA-templated transcription, initiation
SCO0166	COG2326	polyphosphate kinase activity
SCO0172	COG0589	response to stress
SCO0179	COG1063	alcohol dehydrogenase
SCO0180	COG0589	response to stress
SCO0184	COG3046	protein related to deoxyribodipyrimidine photolyase
SCO0185	COG0142	geranyltranstransferase activity
SCO0189	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SCO0190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SCO0208	COG0574	Belongs to the PEP-utilizing enzyme family
SCO0208	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCO0217	COG1140	nitrate reductase beta subunit
SCO0230	COG1309	transcriptional regulator
SCO0234	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0235	COG4221	oxidoreductase activity
SCO0237	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SCO0249	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO0252	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO0259	COG1063	alcohol dehydrogenase
SCO0261	COG0110	maltose O-acetyltransferase activity
SCO0272	COG0395	ABC-type sugar transport system, permease component
SCO0274	COG3345	alpha-galactosidase
SCO0275	COG1940	carbohydrate kinase activity
SCO0278	COG0494	nUDIX hydrolase
SCO0280	COG0494	nUDIX hydrolase
SCO0284	COG3345	alpha-galactosidase
SCO0285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCO0285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SCO0289	COG1609	Transcriptional regulator
SCO0291	COG1175	transmembrane transport
SCO0293	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO0294	COG0110	maltose O-acetyltransferase activity
SCO0298	COG0583	DNA-binding transcription factor activity
SCO0299	COG0667	Aldo Keto reductase
SCO0300	COG2072	flavoprotein involved in K transport
SCO0305	COG2319	Wd-40 repeat
SCO0306	COG1073	alpha beta
SCO0310	COG1309	transcriptional regulator
SCO0311	COG0318	PFAM AMP-dependent synthetase and ligase
SCO0314	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SCO0315	COG0019	diaminopimelate decarboxylase activity
SCO0316	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SCO0316	COG2508	Transcriptional regulator
SCO0322	COG0488	(ABC) transporter
SCO0330	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0338	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SCO0344	COG1802	Transcriptional regulator
SCO0345	COG1414	Transcriptional regulator
SCO0346	COG0179	Fumarylacetoacetate (FAA) hydrolase
SCO0348	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SCO0350	COG3618	amidohydrolase
SCO0352	COG1653	transport
SCO0356	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0358	COG4948	Mandelate Racemase Muconate Lactonizing
SCO0360	COG1609	Transcriptional regulator
SCO0362	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO0368	COG3415	Transposase
SCO0368	COG2801	Transposase and inactivated derivatives
SCO0369	COG3408	Glycogen debranching enzyme
SCO0374	COG1132	(ABC) transporter
SCO0375	COG0477	Major facilitator Superfamily
SCO0379	COG0753	catalase activity
SCO0382	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SCO0386	COG0367	asparagine synthase
SCO0393	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SCO0396	COG4310	Domain of unknown function (DUF2172)
SCO0398	COG1215	transferase activity, transferring glycosyl groups
SCO0401	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SCO0409	COG0739	heme binding
SCO0410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SCO0414	COG1595	DNA-templated transcription, initiation
SCO0421	COG2197	response regulator
SCO0422	COG4585	Histidine kinase
SCO0423	COG2409	Drug exporters of the RND superfamily
SCO0429	COG0667	Aldo Keto reductase
SCO0432	COG1404	Belongs to the peptidase S8 family
SCO0434	COG1263	PTS System
SCO0434	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SCO0435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SCO0438	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SCO0441	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SCO0443	COG1984	allophanate hydrolase subunit 2
SCO0452	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SCO0454	COG1175	transmembrane transport
SCO0455	COG0395	ABC-type sugar transport system, permease component
SCO0456	COG1609	Transcriptional regulator
SCO0461	COG0596	Alpha beta hydrolase
SCO0467	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SCO0469	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO0475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SCO0476	COG1120	ATPase activity
SCO0477	COG0346	lactoylglutathione lyase activity
SCO0479	COG0483	inositol monophosphate 1-phosphatase activity
SCO0488	COG3408	Glycogen debranching enzyme
SCO0490	COG2382	esterase
SCO0491	COG1132	(ABC) transporter
SCO0493	COG1132	(ABC) transporter
SCO0495	COG1120	ATPase activity
SCO0496	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO0497	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO0498	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SCO0504	COG0513	Belongs to the DEAD box helicase family
SCO0506	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SCO0508	COG1309	transcriptional regulator
SCO0509	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SCO0511	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0515	COG0666	response to abiotic stimulus
SCO0519	COG4221	oxidoreductase activity
SCO0522	COG4221	oxidoreductase activity
SCO0523	COG1522	sequence-specific DNA binding
SCO0524	COG3386	PFAM SMP-30 Gluconolaconase
SCO0527	COG1278	Cold shock
SCO0529	COG0673	inositol 2-dehydrogenase activity
SCO0530	COG2188	Transcriptional regulator
SCO0531	COG2182	Extracellular solute-binding protein
SCO0532	COG1175	transmembrane transport
SCO0533	COG0395	ABC-type sugar transport system, permease component
SCO0535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SCO0540	COG0395	ABC-type sugar transport system, permease component
SCO0541	COG1486	melibiose metabolic process
SCO0543	COG0739	heme binding
SCO0547	COG0604	alcohol dehydrogenase
SCO0547	COG3321	synthase
SCO0548	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO0549	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO0550	COG2340	Cysteine-rich secretory protein family
SCO0551	COG2205	protein histidine kinase activity
SCO0552	COG0745	RESPONSE REGULATOR receiver
SCO0557	COG0789	Transcriptional regulator
SCO0560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SCO0565	COG0142	geranyltranstransferase activity
SCO0568	COG0142	geranyltranstransferase activity
SCO0569	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SCO0570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SCO0571	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SCO0572	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SCO0575	COG3340	Belongs to the peptidase S51 family
SCO0576	COG2084	Dehydrogenase
SCO0577	COG1082	Xylose isomerase domain protein TIM barrel
SCO0578	COG0149	triose-phosphate isomerase activity
SCO0579	COG0698	ribose 5-phosphate isomerase
SCO0580	COG2376	Dihydroxyacetone kinase
SCO0582	COG2186	Transcriptional regulator
SCO0583	COG2124	cytochrome p450
SCO0584	COG2124	cytochrome p450
SCO0587	COG2018	Roadblock/LC7 domain
SCO0589	COG0583	DNA-binding transcription factor activity
SCO0595	COG0655	NAD(P)H dehydrogenase (quinone) activity
SCO0596	COG0783	Belongs to the Dps family
SCO0600	COG1191	sigma factor activity
SCO0601	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SCO0603	COG0505	Belongs to the CarA family
SCO0613	COG2235	arginine
SCO0617	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SCO0620	COG1937	Protein conserved in bacteria
SCO0621	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCO0628	COG1233	COG1233 Phytoene dehydrogenase and related
SCO0632	COG1595	DNA-templated transcription, initiation
SCO0636	COG0488	(ABC) transporter
SCO0643	COG3397	chitin binding
SCO0647	COG4221	oxidoreductase activity
SCO0659	COG1609	Transcriptional regulator
SCO0661	COG1175	transmembrane transport
SCO0662	COG0395	ABC-type sugar transport system, permease component
SCO0663	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SCO0668	COG0277	FAD linked oxidase domain protein
SCO0676	COG3290	protein histidine kinase activity
SCO0680	COG0477	Major facilitator Superfamily
SCO0686	COG1295	ribonuclease BN
SCO0687	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0689	COG2080	2 iron, 2 sulfur cluster binding
SCO0690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SCO0691	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SCO0700	COG1132	(ABC) transporter
SCO0710	COG0410	ABC transporter
SCO0711	COG2508	Transcriptional regulator
SCO0714	COG0673	inositol 2-dehydrogenase activity
SCO0728	COG1309	transcriptional regulator
SCO0734	COG1846	Transcriptional regulator
SCO0734	COG1940	carbohydrate kinase activity
SCO0735	COG0673	inositol 2-dehydrogenase activity
SCO0739	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0742	COG1132	(ABC) transporter
SCO0757	COG0248	Ppx GppA phosphatase
SCO0760	COG2890	protein-(glutamine-N5) methyltransferase activity
SCO0766	COG3250	beta-galactosidase activity
SCO0769	COG0667	Aldo Keto reductase
SCO0774	COG2124	cytochrome p450
SCO0777	COG0435	Glutathione S-transferase
SCO0781	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO0782	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SCO0789	COG1796	DNA polymerase
SCO0789	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SCO0798	COG2706	6-phosphogluconolactonase activity
SCO0800	COG1309	transcriptional regulator
SCO0802	COG1357	PFAM Pentapeptide repeats (8 copies)
SCO0803	COG1595	DNA-templated transcription, initiation
SCO0806	COG1609	Transcriptional regulator
SCO0808	COG1879	ABC-type sugar transport system periplasmic component
SCO0810	COG1172	Belongs to the binding-protein-dependent transport system permease family
SCO0811	COG1129	ABC transporter
SCO0812	COG4952	isomerase
SCO0813	COG3347	Dehydrogenase
SCO0813	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0814	COG1070	Carbohydrate kinase
SCO0815	COG0247	lactate metabolic process
SCO0816	COG1139	Iron-sulfur cluster binding protein
SCO0817	COG1556	Lactate utilization protein
SCO0818	COG0577	efflux transmembrane transporter activity
SCO0818	COG1136	(ABC) transporter
SCO0823	COG1725	Transcriptional regulator
SCO0824	COG1131	(ABC) transporter
SCO0828	COG3540	Alkaline phosphatase
SCO0836	COG0668	transmembrane transport
SCO0839	COG2409	Drug exporters of the RND superfamily
SCO0840	COG1846	Transcriptional regulator
SCO0841	COG0702	epimerase
SCO0852	COG0800	Aldolase
SCO0857	COG1309	transcriptional regulator
SCO0870	COG0784	Response regulator, receiver
SCO0871	COG4251	negative regulation of phosphorylation
SCO0879	COG1131	(ABC) transporter
SCO0883	COG0242	peptide deformylase activity
SCO0884	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCO0885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCO0886	COG1609	Transcriptional regulator
SCO0889	COG0583	DNA-binding transcription factor activity
SCO0890	COG4221	oxidoreductase activity
SCO0894	COG3976	FMN-binding domain protein
SCO0894	COG1053	succinate dehydrogenase
SCO0895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SCO0896	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SCO0898	COG3629	intracellular signal transduction
SCO0898	COG3903	Transcriptional regulator
SCO0899	COG0596	Alpha beta hydrolase
SCO0910	COG3572	ergothioneine biosynthetic process
SCO0911	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SCO0912	COG0121	glutamine amidotransferase
SCO0913	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SCO0914	COG2182	Extracellular solute-binding protein
SCO0915	COG3360	Dodecin
SCO0917	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO0922	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SCO0923	COG1053	succinate dehydrogenase
SCO0925	COG0583	DNA-binding transcription factor activity
SCO0927	COG0583	DNA-binding transcription factor activity
SCO0936	COG0726	polysaccharide deacetylase
SCO0938	COG0531	amino acid
SCO0945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SCO0950	COG0395	ABC-type sugar transport system, permease component
SCO0951	COG1175	transmembrane transport
SCO0952	COG1653	transport
SCO0953	COG1609	Transcriptional regulator
SCO0959	COG3537	Alpha-1,2-mannosidase
SCO0961	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SCO0962	COG0297	glycogen (starch) synthase activity
SCO0970	COG1028	Short-chain dehydrogenase reductase Sdr
SCO0971	COG0583	DNA-binding transcription factor activity
SCO0975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SCO0978	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SCO0983	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SCO0985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SCO0992	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SCO0993	COG1181	Belongs to the D-alanine--D-alanine ligase family
SCO0995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SCO0996	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SCO0997	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO0998	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SCO0999	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SCO1005	COG3547	Transposase (IS116 IS110 IS902 family)
SCO1012	COG1028	Short-chain dehydrogenase reductase Sdr
SCO1018	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SCO1019	COG0463	Glycosyl transferase, family 2
SCO1026	COG1349	DNA-binding transcription factor activity
SCO1028	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SCO1031	COG0577	efflux transmembrane transporter activity
SCO1032	COG1136	(ABC) transporter
SCO1039	COG1940	carbohydrate kinase activity
SCO1041	COG2813	Specifically methylates the guanine in position
SCO1045	COG2608	mercury ion transmembrane transporter activity
SCO1049	COG0673	inositol 2-dehydrogenase activity
SCO1050	COG0783	Belongs to the Dps family
SCO1055	COG1501	Belongs to the glycosyl hydrolase 31 family
SCO1056	COG1653	transport
SCO1057	COG1175	transmembrane transport
SCO1058	COG0395	ABC-type sugar transport system, permease component
SCO1059	COG2723	6-phospho-beta-galactosidase activity
SCO1062	COG3250	beta-galactosidase activity
SCO1063	COG0395	ABC-type sugar transport system, permease component
SCO1064	COG1175	transmembrane transport
SCO1066	COG1609	Transcriptional regulator
SCO1067	COG0738	Major facilitator superfamily
SCO1070	COG2197	response regulator
SCO1071	COG4585	Histidine kinase
SCO1073	COG0445	tRNA wobble uridine modification
SCO1075	COG1660	Displays ATPase and GTPase activities
SCO1081	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SCO1085	COG0204	Acyl-transferase
SCO1090	COG0584	glycerophosphoryl diester phosphodiesterase
SCO1094	COG1309	transcriptional regulator
SCO1102	COG0671	phosphoesterase, PA-phosphatase related
SCO1104	COG1309	transcriptional regulator
SCO1108	COG0640	Transcriptional regulator
SCO1109	COG1902	pentaerythritol trinitrate reductase activity
SCO1112	COG1960	acyl-CoA dehydrogenase activity
SCO1114	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SCO1120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCO1127	COG4221	oxidoreductase activity
SCO1130	COG3387	PFAM Glycoside hydrolase 15-related
SCO1132	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SCO1133	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SCO1134	COG2080	2 iron, 2 sulfur cluster binding
SCO1136	COG4565	transcriptional regulatory protein
SCO1137	COG3290	protein histidine kinase activity
SCO1141	COG0432	Pfam Uncharacterised protein family UPF0047
SCO1142	COG2072	flavoprotein involved in K transport
SCO1144	COG1132	(ABC) transporter
SCO1147	COG1132	(ABC) transporter
SCO1148	COG1132	(ABC) transporter
SCO1150	COG0254	rRNA binding
SCO1153	COG1946	Acyl-CoA thioesterase
SCO1155	COG2018	Roadblock/LC7 domain
SCO1167	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SCO1169	COG2115	Belongs to the xylose isomerase family
SCO1170	COG1070	Carbohydrate kinase
SCO1171	COG1940	carbohydrate kinase activity
SCO1174	COG1012	belongs to the aldehyde dehydrogenase family
SCO1175	COG0657	acetylesterase activity
SCO1176	COG0129	dihydroxy-acid dehydratase activity
SCO1180	COG0592	DNA-directed DNA polymerase activity
SCO1183	COG0714	Associated with various cellular activities
SCO1190	COG0477	Major facilitator Superfamily
SCO1194	COG0477	Major facilitator Superfamily
SCO1197	COG1960	acyl-CoA dehydrogenase activity
SCO1198	COG1960	acyl-CoA dehydrogenase activity
SCO1200	COG3800	Transcriptional regulator
SCO1200	COG1396	sequence-specific DNA binding
SCO1202	COG1793	dna ligase
SCO1204	COG1012	belongs to the aldehyde dehydrogenase family
SCO1206	COG3424	synthase
SCO1207	COG2124	cytochrome p450
SCO1209	COG1960	acyl-CoA dehydrogenase activity
SCO1211	COG0242	peptide deformylase activity
SCO1212	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SCO1213	COG3442	glutamine amidotransferase
SCO1214	COG0205	6-phosphofructokinase activity
SCO1217	COG3275	phosphorelay sensor kinase activity
SCO1218	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCO1220	COG3279	Response regulator of the LytR AlgR family
SCO1221	COG1522	sequence-specific DNA binding
SCO1222	COG1834	amidinotransferase
SCO1223	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SCO1225	COG0477	Major facilitator Superfamily
SCO1228	COG0204	Acyl-transferase
SCO1230	COG0596	Alpha beta hydrolase
SCO1231	COG0829	nickel cation binding
SCO1232	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SCO1234	COG0804	urea catabolic process
SCO1235	COG0832	Belongs to the urease beta subunit family
SCO1236	COG0831	urea catabolic process
SCO1237	COG2161	toxin-antitoxin pair type II binding
SCO1238	COG0740	serine-type endopeptidase activity
SCO1243	COG0156	8-amino-7-oxononanoate synthase activity
SCO1244	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SCO1245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SCO1246	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SCO1247	COG2226	methyltransferase
SCO1250	COG0456	acetyltransferase
SCO1254	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SCO1259	COG4585	Histidine kinase
SCO1260	COG2197	response regulator
SCO1261	COG1940	carbohydrate kinase activity
SCO1262	COG2188	Transcriptional regulator
SCO1263	COG1595	DNA-templated transcription, initiation
SCO1264	COG0596	Alpha beta hydrolase
SCO1264	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCO1266	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO1267	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO1268	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCO1269	COG0022	dehydrogenase e1 component
SCO1270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SCO1271	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCO1272	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO1273	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO1273	COG3320	Male sterility
SCO1278	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SCO1279	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SCO1281	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SCO1281	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SCO1289	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SCO1294	COG0626	cystathionine gamma-synthase activity
SCO1299	COG1522	sequence-specific DNA binding
SCO1300	COG0419	ATPase involved in DNA repair
SCO1301	COG0420	3'-5' exonuclease activity
SCO1302	COG1739	Uncharacterized protein family UPF0029
SCO1304	COG1832	CoA-binding protein
SCO1305	COG3864	Putative metallopeptidase domain
SCO1306	COG0714	Associated with various cellular activities
SCO1309	COG0640	Transcriptional regulator
SCO1314	COG0110	maltose O-acetyltransferase activity
SCO1321	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SCO1324	COG0183	Belongs to the thiolase family
SCO1326	COG1968	undecaprenyl-diphosphatase activity
SCO1327	COG2208	phosphoserine phosphatase activity
SCO1327	COG2770	Histidine kinase
SCO1335	COG1028	Short-chain dehydrogenase reductase Sdr
SCO1336	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SCO1338	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO1340	COG2318	DinB family
SCO1343	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SCO1352	COG0006	proline dipeptidase activity
SCO1356	COG0723	plastoquinol--plastocyanin reductase activity
SCO1359	COG0697	spore germination
SCO1367	COG1136	(ABC) transporter
SCO1370	COG2197	response regulator
SCO1371	COG0384	phenazine biosynthesis protein PhzF
SCO1376	COG1609	Transcriptional regulator
SCO1378	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SCO1378	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SCO1380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SCO1384	COG1716	ATPase activity
SCO1388	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SCO1391	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCO1393	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SCO1396	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SCO1398	COG3706	GGDEF domain
SCO1401	COG2018	Roadblock/LC7 domain
SCO1405	COG0326	Molecular chaperone. Has ATPase activity
SCO1411	COG2814	Major facilitator Superfamily
SCO1412	COG4336	lyase activity
SCO1418	COG2364	Membrane
SCO1420	COG2270	Major facilitator Superfamily
SCO1423	COG0463	Glycosyl transferase, family 2
SCO1428	COG1960	acyl-CoA dehydrogenase activity
SCO1438	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SCO1439	COG0140	phosphoribosyl-ATP diphosphatase activity
SCO1440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SCO1441	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SCO1441	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SCO1442	COG3201	nicotinamide mononucleotide transporter
SCO1448	COG2223	nitrite transmembrane transporter activity
SCO1450	COG2233	PERMEase
SCO1455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SCO1459	COG0531	amino acid
SCO1463	COG2390	Transcriptional regulator
SCO1464	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SCO1465	COG1653	transport
SCO1468	COG0515	serine threonine protein kinase
SCO1471	COG3415	Transposase
SCO1471	COG2801	Transposase and inactivated derivatives
SCO1473	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SCO1476	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SCO1478	COG1758	RNA polymerase activity
SCO1479	COG0194	GDP metabolic process
SCO1481	COG0284	orotidine-5'-phosphate decarboxylase activity
SCO1482	COG0167	dihydroorotate dehydrogenase activity
SCO1483	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SCO1484	COG0505	Belongs to the CarA family
SCO1486	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SCO1487	COG0540	Belongs to the ATCase OTCase family
SCO1488	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SCO1490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SCO1491	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SCO1492	COG0006	proline dipeptidase activity
SCO1494	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SCO1495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SCO1496	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SCO1498	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SCO1500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SCO1501	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SCO1505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SCO1508	COG0124	histidyl-tRNA synthetase
SCO1510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SCO1511	COG1196	nuclear chromosome segregation
SCO1513	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SCO1514	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SCO1515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SCO1516	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SCO1518	COG2255	four-way junction helicase activity
SCO1519	COG0632	four-way junction helicase activity
SCO1520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SCO1521	COG0217	transcriptional regulatory protein
SCO1522	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SCO1523	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SCO1525	COG0438	transferase activity, transferring glycosyl groups
SCO1526	COG1560	Kdo2-lipid A biosynthetic process
SCO1527	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SCO1531	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SCO1534	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SCO1537	COG0395	ABC-type sugar transport system, permease component
SCO1538	COG1175	transmembrane transport
SCO1545	COG0456	acetyltransferase
SCO1547	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SCO1553	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SCO1553	COG1648	precorrin-2 dehydrogenase activity
SCO1554	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SCO1557	COG1464	Belongs to the NlpA lipoprotein family
SCO1558	COG2011	ABC-type metal ion transport system permease component
SCO1559	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SCO1560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCO1565	COG0584	glycerophosphoryl diester phosphodiesterase
SCO1566	COG0204	Acyl-transferase
SCO1566	COG0318	PFAM AMP-dependent synthetase and ligase
SCO1567	COG0477	Major facilitator Superfamily
SCO1570	COG0165	Argininosuccinate lyase
SCO1576	COG1438	arginine binding
SCO1577	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SCO1578	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SCO1579	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SCO1580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SCO1588	COG0697	spore germination
SCO1590	COG1649	PFAM Uncharacterised BCR, COG1649
SCO1594	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCO1594	COG0072	phenylalanine-tRNA ligase activity
SCO1595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SCO1596	COG5002	protein histidine kinase activity
SCO1597	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SCO1598	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SCO1599	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SCO1600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SCO1603	COG3547	Transposase (IS116 IS110 IS902 family)
SCO1604	COG2318	DinB family
SCO1612	COG1012	belongs to the aldehyde dehydrogenase family
SCO1613	COG0174	glutamine synthetase
SCO1614	COG2186	Transcriptional regulator
SCO1615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SCO1620	COG4176	ABC-type proline glycine betaine transport system permease component
SCO1621	COG4175	Glycine betaine
SCO1621	COG0517	IMP dehydrogenase activity
SCO1622	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SCO1625	COG0564	pseudouridine synthase activity
SCO1632	COG0805	protein transport
SCO1633	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SCO1639	COG0545	Peptidyl-prolyl cis-trans isomerase
SCO1640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SCO1642	COG1609	Transcriptional regulator
SCO1643	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SCO1644	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SCO1647	COG4122	O-methyltransferase activity
SCO1648	COG1222	aaa ATPase
SCO1652	COG1994	Peptidase M50
SCO1652	COG0517	IMP dehydrogenase activity
SCO1654	COG2197	response regulator
SCO1655	COG4166	transmembrane transport
SCO1656	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCO1657	COG1410	methionine synthase
SCO1657	COG0646	methionine synthase
SCO1658	COG1414	Transcriptional regulator
SCO1659	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SCO1660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SCO1661	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SCO1663	COG0215	cysteine-tRNA ligase activity
SCO1666	COG0588	phosphoglycerate mutase activity
SCO1667	COG0598	Magnesium transport protein CorA
SCO1669	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO1670	COG0667	Aldo Keto reductase
SCO1677	COG3012	SEC-C Motif Domain Protein
SCO1679	COG3265	gluconokinase activity
SCO1681	COG1028	Short-chain dehydrogenase reductase Sdr
SCO1682	COG1063	alcohol dehydrogenase
SCO1686	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SCO1687	COG2149	membrane
SCO1697	COG0789	Transcriptional regulator
SCO1701	COG1960	acyl-CoA dehydrogenase activity
SCO1703	COG0640	Transcriptional regulator
SCO1707	COG3842	ATPase activity
SCO1710	COG2851	Citrate transporter
SCO1711	COG0243	molybdopterin cofactor binding
SCO1712	COG1309	transcriptional regulator
SCO1715	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SCO1716	COG2188	Transcriptional regulator
SCO1723	COG1595	DNA-templated transcription, initiation
SCO1725	COG2755	lipolytic protein G-D-S-L family
SCO1728	COG1725	Transcriptional regulator
SCO1737	COG0662	Cupin 2, conserved barrel domain protein
SCO1737	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SCO1739	COG0587	DNA-directed DNA polymerase activity
SCO1744	COG4585	Histidine kinase
SCO1745	COG2197	response regulator
SCO1749	COG1799	cell septum assembly
SCO1751	COG0477	Major facilitator Superfamily
SCO1753	COG0671	phosphoesterase, PA-phosphatase related
SCO1758	COG1160	GTP binding
SCO1760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SCO1765	COG3541	Predicted nucleotidyltransferase
SCO1767	COG0494	nUDIX hydrolase
SCO1768	COG1187	pseudouridine synthase activity
SCO1769	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SCO1770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SCO1773	COG0686	Belongs to the AlaDH PNT family
SCO1775	COG0494	nUDIX hydrolase
SCO1776	COG0504	CTP synthase activity
SCO1777	COG3387	PFAM Glycoside hydrolase 15-related
SCO1779	COG0438	transferase activity, transferring glycosyl groups
SCO1780	COG0497	DNA recombination
SCO1781	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SCO1785	COG1120	ATPase activity
SCO1786	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO1787	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO1788	COG0647	UMP catabolic process
SCO1792	COG2094	Belongs to the DNA glycosylase MPG family
SCO1794	COG1881	PFAM PEBP family protein
SCO1798	COG1119	ATPase activity
SCO1801	COG2197	response regulator
SCO1802	COG4585	Histidine kinase
SCO1803	COG4221	oxidoreductase activity
SCO1804	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SCO1806	COG0842	Transport permease protein
SCO1806	COG1131	(ABC) transporter
SCO1806	COG1716	ATPase activity
SCO1808	COG3830	Belongs to the UPF0237 family
SCO1808	COG0560	Phosphoserine phosphatase
SCO1813	COG2186	Transcriptional regulator
SCO1815	COG1028	Short-chain dehydrogenase reductase Sdr
SCO1818	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SCO1821	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SCO1822	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCO1824	COG1404	Belongs to the peptidase S8 family
SCO1827	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SCO1830	COG3387	PFAM Glycoside hydrolase 15-related
SCO1838	COG1024	Enoyl-CoA hydratase
SCO1840	COG0488	(ABC) transporter
SCO1844	COG0235	Class ii aldolase
SCO1847	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SCO1848	COG1492	cobalamin metabolic process
SCO1852	COG1797	cobyrinic acid a,c-diamide synthase activity
SCO1864	COG0456	acetyltransferase
SCO1865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SCO1866	COG1917	Cupin 2, conserved barrel domain protein
SCO1867	COG5285	phytanoyl-CoA dioxygenase
SCO1872	COG1414	Transcriptional regulator
SCO1875	COG0768	penicillin binding
SCO1876	COG1595	DNA-templated transcription, initiation
SCO1879	COG4677	pectinesterase activity
SCO1880	COG3866	Pectate lyase
SCO1881	COG2755	lipolytic protein G-D-S-L family
SCO1883	COG3507	Belongs to the glycosyl hydrolase 43 family
SCO1886	COG0395	ABC-type sugar transport system, permease component
SCO1887	COG1175	transmembrane transport
SCO1890	COG1802	Transcriptional regulator
SCO1895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCO1896	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCO1897	COG1349	DNA-binding transcription factor activity
SCO1901	COG1063	alcohol dehydrogenase
SCO1904	COG1309	transcriptional regulator
SCO1912	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCO1916	COG2171	N-acyltransferase activity
SCO1917	COG3226	Transcriptional regulator
SCO1918	COG2076	Multidrug Resistance protein
SCO1919	COG2151	metal-sulfur cluster biosynthetic enzyme
SCO1920	COG0822	iron-sulfur transferase activity
SCO1921	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SCO1922	COG0396	ATPase activity
SCO1924	COG0719	Fe-S assembly protein
SCO1927	COG2746	aminoglycoside 3-N-acetyltransferase activity
SCO1928	COG1131	(ABC) transporter
SCO1934	COG0109	protoheme IX farnesyltransferase activity
SCO1936	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SCO1939	COG0363	glucosamine-6-phosphate deaminase activity
SCO1942	COG0166	Belongs to the GPI family
SCO1944	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SCO1945	COG0149	triose-phosphate isomerase activity
SCO1946	COG0126	phosphoglycerate kinase activity
SCO1947	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SCO1950	COG1481	regulation of sporulation
SCO1951	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SCO1952	COG1660	Displays ATPase and GTPase activities
SCO1953	COG0322	excinuclease ABC activity
SCO1958	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SCO1961	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SCO1962	COG0387	Pfam Sodium calcium exchanger
SCO1966	COG0556	nucleotide-excision repair
SCO1968	COG0584	glycerophosphoryl diester phosphodiesterase
SCO1971	COG2313	pseudouridylate synthase activity
SCO1972	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SCO1972	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SCO1973	COG2226	methyltransferase
SCO1984	COG0402	S-adenosylhomocysteine deaminase activity
SCO1989	COG2267	carboxylic ester hydrolase activity
SCO1993	COG2226	methyltransferase
SCO1996	COG0237	dephospho-CoA kinase activity
SCO1999	COG2226	methyltransferase
SCO2000	COG1643	Atp-dependent helicase
SCO2005	COG2050	protein possibly involved in aromatic compounds catabolism
SCO2011	COG0411	ABC transporter
SCO2015	COG0737	Belongs to the 5'-nucleotidase family
SCO2019	COG0287	Prephenate dehydrogenase
SCO2019	COG1605	Chorismate mutase
SCO2021	COG2968	Membrane
SCO2022	COG2304	oxidoreductase activity
SCO2026	COG0067	glutamate synthase
SCO2026	COG0069	glutamate synthase activity
SCO2026	COG0070	glutamate synthase
SCO2032	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO2033	COG2301	Belongs to the HpcH HpaI aldolase family
SCO2034	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SCO2036	COG0159	tryptophan synthase activity
SCO2037	COG0133	tryptophan synthase activity
SCO2039	COG0134	indole-3-glycerol-phosphate synthase activity
SCO2044	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SCO2048	COG0107	imidazoleglycerol-phosphate synthase activity
SCO2049	COG0251	oxidation-reduction process
SCO2050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SCO2051	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SCO2052	COG0131	Imidazoleglycerol-phosphate dehydratase
SCO2053	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SCO2054	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SCO2058	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SCO2062	COG1432	Conserved Protein
SCO2064	COG0587	DNA-directed DNA polymerase activity
SCO2071	COG0025	NhaP-type Na H and K H
SCO2074	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SCO2076	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SCO2077	COG3599	regulation of cell shape
SCO2079	COG1799	cell septum assembly
SCO2081	COG1496	oxidoreductase activity
SCO2082	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SCO2083	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SCO2084	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SCO2086	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SCO2087	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SCO2089	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SCO2090	COG0768	penicillin binding
SCO2092	COG0275	rRNA processing
SCO2094	COG0714	Associated with various cellular activities
SCO2100	COG1309	transcriptional regulator
SCO2101	COG1233	COG1233 Phytoene dehydrogenase and related
SCO2104	COG0352	thiamine-phosphate diphosphorylase activity
SCO2106	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SCO2107	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SCO2107	COG2022	thiamine diphosphate biosynthetic process
SCO2109	COG2022	thiamine diphosphate biosynthetic process
SCO2110	COG0515	serine threonine protein kinase
SCO2110	COG2815	serine threonine protein kinase
SCO2111	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SCO2112	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SCO2113	COG2193	ferroxidase activity
SCO2115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SCO2118	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SCO2119	COG0205	6-phosphofructokinase activity
SCO2121	COG4585	Histidine kinase
SCO2126	COG1940	carbohydrate kinase activity
SCO2128	COG0003	Pfam Anion-transporting ATPase
SCO2131	COG1022	Amp-dependent synthetase and ligase
SCO2132	COG0438	transferase activity, transferring glycosyl groups
SCO2142	COG2205	protein histidine kinase activity
SCO2143	COG0745	RESPONSE REGULATOR receiver
SCO2145	COG1929	Belongs to the glycerate kinase type-1 family
SCO2146	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SCO2147	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SCO2148	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SCO2149	COG0723	plastoquinol--plastocyanin reductase activity
SCO2150	COG2010	Cytochrome c
SCO2151	COG1845	cytochrome c oxidase, subunit III
SCO2153	COG1376	ErfK ybiS ycfS ynhG family protein
SCO2155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SCO2156	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SCO2158	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCO2162	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SCO2164	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SCO2165	COG2197	response regulator
SCO2166	COG4585	Histidine kinase
SCO2170	COG2226	methyltransferase
SCO2171	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCO2175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SCO2177	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SCO2179	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SCO2180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCO2181	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCO2183	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SCO2190	COG1090	epimerase
SCO2193	COG0321	lipoyl(octanoyl) transferase activity
SCO2194	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SCO2198	COG0174	glutamine synthetase
SCO2200	COG0702	epimerase
SCO2201	COG1733	regulation of RNA biosynthetic process
SCO2202	COG0501	Belongs to the peptidase M48B family
SCO2213	COG0745	RESPONSE REGULATOR receiver
SCO2216	COG2197	response regulator
SCO2223	COG1309	transcriptional regulator
SCO2228	COG0366	Alpha amylase catalytic
SCO2229	COG3833	ABC-type maltose transport systems, permease component
SCO2230	COG1175	transmembrane transport
SCO2231	COG1653	transport
SCO2232	COG1609	Transcriptional regulator
SCO2234	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SCO2235	COG2161	toxin-antitoxin pair type II binding
SCO2236	COG4115	mRNA cleavage
SCO2238	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SCO2238	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SCO2241	COG0174	glutamine synthetase
SCO2254	COG2814	Major facilitator Superfamily
SCO2256	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SCO2260	COG1994	Peptidase M50
SCO2267	COG5398	heme oxygenase
SCO2268	COG0384	phenazine biosynthesis protein PhzF
SCO2272	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SCO2273	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO2274	COG1120	ATPase activity
SCO2276	COG2837	iron assimilation
SCO2277	COG0672	)-iron permease
SCO2281	COG2197	response regulator
SCO2283	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SCO2284	COG2814	Major facilitator Superfamily
SCO2286	COG3540	Alkaline phosphatase
SCO2287	COG1028	Short-chain dehydrogenase reductase Sdr
SCO2297	COG3022	response to hydroperoxide
SCO2298	COG0800	Aldolase
SCO2301	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SCO2304	COG2030	dehydratase
SCO2305	COG1131	(ABC) transporter
SCO2307	COG4585	Histidine kinase
SCO2308	COG2197	response regulator
SCO2310	COG0477	Major facilitator Superfamily
SCO2313	COG2247	cell wall binding repeat
SCO2313	COG0860	N-Acetylmuramoyl-L-alanine amidase
SCO2318	COG0438	transferase activity, transferring glycosyl groups
SCO2319	COG1309	transcriptional regulator
SCO2324	COG3845	ABC transporter
SCO2332	COG2267	carboxylic ester hydrolase activity
SCO2338	COG4122	O-methyltransferase activity
SCO2359	COG4585	Histidine kinase
SCO2360	COG0586	Pfam SNARE associated Golgi protein
SCO2362	COG1358	cellular component organization or biogenesis
SCO2371	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SCO2373	COG0477	Major facilitator Superfamily
SCO2374	COG1309	transcriptional regulator
SCO2377	COG0667	Aldo Keto reductase
SCO2378	COG0789	Transcriptional regulator
SCO2388	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCO2389	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO2390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO2396	COG1764	response to oxidative stress
SCO2397	COG2130	NADP-dependent
SCO2405	COG1129	ABC transporter
SCO2406	COG4214	carbohydrate transport
SCO2408	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SCO2415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SCO2420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SCO2427	COG3507	Belongs to the glycosyl hydrolase 43 family
SCO2428	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SCO2432	COG0395	ABC-type sugar transport system, permease component
SCO2433	COG1175	transmembrane transport
SCO2439	COG3386	PFAM SMP-30 Gluconolaconase
SCO2440	COG1414	Transcriptional regulator
SCO2442	COG2186	Transcriptional regulator
SCO2444	COG0318	PFAM AMP-dependent synthetase and ligase
SCO2445	COG0825	malonyl-CoA metabolic process
SCO2445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SCO2446	COG1404	Belongs to the peptidase S8 family
SCO2450	COG0515	serine threonine protein kinase
SCO2450	COG2815	serine threonine protein kinase
SCO2451	COG1077	Cell shape determining protein MreB Mrl
SCO2454	COG2409	Drug exporters of the RND superfamily
SCO2455	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SCO2456	COG3766	membrane
SCO2462	COG1070	Carbohydrate kinase
SCO2465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SCO2468	COG0358	DNA primase activity
SCO2470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SCO2473	COG0243	molybdopterin cofactor binding
SCO2475	COG0583	DNA-binding transcription factor activity
SCO2476	COG1028	Short-chain dehydrogenase reductase Sdr
SCO2487	COG2146	nitrite reductase [NAD(P)H] activity
SCO2487	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SCO2489	COG1309	transcriptional regulator
SCO2490	COG1028	Short-chain dehydrogenase reductase Sdr
SCO2493	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SCO2494	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCO2494	COG0574	Belongs to the PEP-utilizing enzyme family
SCO2499	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SCO2502	COG0477	Major facilitator Superfamily
SCO2504	COG0423	glycine-tRNA ligase activity
SCO2505	COG3443	Belongs to the bacterial solute-binding protein 9 family
SCO2505	COG0803	Belongs to the bacterial solute-binding protein 9 family
SCO2506	COG1121	(ABC) transporter
SCO2507	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SCO2509	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SCO2510	COG1381	Involved in DNA repair and RecF pathway recombination
SCO2517	COG2197	response regulator
SCO2519	COG2409	Drug exporters of the RND superfamily
SCO2528	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SCO2533	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SCO2535	COG2315	Protein conserved in bacteria
SCO2539	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SCO2540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCO2542	COG4948	Mandelate Racemase Muconate Lactonizing
SCO2543	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCO2546	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SCO2547	COG1234	tRNA 3'-trailer cleavage
SCO2548	COG0537	adenosine 5'-monophosphoramidase activity
SCO2549	COG4946	Tricorn protease homolog
SCO2549	COG0793	Belongs to the peptidase S41A family
SCO2554	COG0484	heat shock protein binding
SCO2555	COG1420	regulation of RNA biosynthetic process
SCO2562	COG0481	GTPase activity
SCO2563	COG0268	Binds directly to 16S ribosomal RNA
SCO2566	COG2353	YceI-like domain
SCO2567	COG1234	tRNA 3'-trailer cleavage
SCO2569	COG1307	EDD domain protein, DegV family
SCO2571	COG0495	leucyl-tRNA aminoacylation
SCO2573	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SCO2576	COG0406	alpha-ribazole phosphatase activity
SCO2577	COG0799	negative regulation of ribosome biogenesis
SCO2579	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SCO2582	COG0501	Belongs to the peptidase M48B family
SCO2585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SCO2587	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SCO2589	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SCO2590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SCO2592	COG0438	transferase activity, transferring glycosyl groups
SCO2594	COG0438	transferase activity, transferring glycosyl groups
SCO2595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SCO2596	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SCO2597	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SCO2598	COG0371	Dehydrogenase
SCO2599	COG1530	ribonuclease E activity
SCO2607	COG0772	Belongs to the SEDS family
SCO2608	COG0768	penicillin binding
SCO2611	COG1077	Cell shape determining protein MreB Mrl
SCO2612	COG0105	UTP biosynthetic process
SCO2614	COG0285	dihydrofolate synthase activity
SCO2615	COG0525	valine-tRNA ligase activity
SCO2617	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SCO2618	COG0740	serine-type endopeptidase activity
SCO2619	COG0740	serine-type endopeptidase activity
SCO2620	COG0544	peptidyl-prolyl cis-trans isomerase activity
SCO2622	COG3594	Acyltransferase
SCO2625	COG4552	Acetyltransferase involved in intracellular survival and related
SCO2628	COG1113	amino acid transport
SCO2630	COG1268	BioY protein
SCO2631	COG1113	amino acid transport
SCO2632	COG2801	Transposase and inactivated derivatives
SCO2632	COG3415	Transposase
SCO2633	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SCO2634	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SCO2646	COG0697	spore germination
SCO2647	COG1846	Transcriptional regulator
SCO2651	COG1028	Short-chain dehydrogenase reductase Sdr
SCO2652	COG1959	2 iron, 2 sulfur cluster binding
SCO2656	COG0668	transmembrane transport
SCO2658	COG1653	transport
SCO2659	COG1175	transmembrane transport
SCO2660	COG0395	ABC-type sugar transport system, permease component
SCO2661	COG1486	melibiose metabolic process
SCO2664	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SCO2666	COG0515	serine threonine protein kinase
SCO2670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SCO2674	COG0577	efflux transmembrane transporter activity
SCO2674	COG1136	(ABC) transporter
SCO2681	COG3903	Transcriptional regulator
SCO2681	COG3629	intracellular signal transduction
SCO2683	COG0629	single-stranded DNA binding
SCO2687	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SCO2693	COG2175	clavaminate synthase activity
SCO2695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SCO2696	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SCO2700	COG2304	oxidoreductase activity
SCO2706	COG0438	transferase activity, transferring glycosyl groups
SCO2707	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SCO2711	COG0438	transferase activity, transferring glycosyl groups
SCO2720	COG1022	Amp-dependent synthetase and ligase
SCO2723	COG1131	(ABC) transporter
SCO2729	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO2734	COG0583	DNA-binding transcription factor activity
SCO2737	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SCO2742	COG1595	DNA-templated transcription, initiation
SCO2746	COG1129	ABC transporter
SCO2747	COG1879	ABC-type sugar transport system periplasmic component
SCO2748	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCO2749	COG1869	D-ribose catabolic process
SCO2752	COG0673	inositol 2-dehydrogenase activity
SCO2758	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO2759	COG3547	Transposase (IS116 IS110 IS902 family)
SCO2766	COG2356	endonuclease I
SCO2769	COG3960	tartronate-semialdehyde synthase activity
SCO2773	COG1946	Acyl-CoA thioesterase
SCO2775	COG1309	transcriptional regulator
SCO2776	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SCO2779	COG1960	acyl-CoA dehydrogenase activity
SCO2783	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SCO2789	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SCO2790	COG0589	response to stress
SCO2792	COG4977	sequence-specific DNA binding
SCO2793	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SCO2797	COG0395	ABC-type sugar transport system, permease component
SCO2799	COG3693	PFAM glycoside hydrolase, family 10
SCO2799	COG3509	depolymerase
SCO2801	COG0745	RESPONSE REGULATOR receiver
SCO2803	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SCO2811	COG0640	Transcriptional regulator
SCO2813	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SCO2814	COG4106	trans-aconitate 2-methyltransferase activity
SCO2816	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO2824	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SCO2828	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SCO2829	COG0765	amino acid transport
SCO2830	COG0765	amino acid transport
SCO2831	COG1126	abc transporter atp-binding protein
SCO2833	COG3397	chitin binding
SCO2840	COG0583	DNA-binding transcription factor activity
SCO2845	COG2188	Transcriptional regulator
SCO2847	COG0673	inositol 2-dehydrogenase activity
SCO2848	COG4702	Belongs to the UPF0303 family
SCO2863	COG0556	nucleotide-excision repair
SCO2872	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SCO2873	COG0456	acetyltransferase
SCO2876	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO2885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO2894	COG4555	ABC transporter
SCO2897	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SCO2902	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SCO2904	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SCO2905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SCO2906	COG1263	PTS System
SCO2907	COG1263	PTS System
SCO2908	COG1234	tRNA 3'-trailer cleavage
SCO2914	COG1113	amino acid transport
SCO2916	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SCO2918	COG1335	isochorismatase
SCO2922	COG1714	RDD family
SCO2925	COG0277	FAD linked oxidase domain protein
SCO2927	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SCO2930	COG1174	glycine betaine transport
SCO2932	COG1174	glycine betaine transport
SCO2934	COG3480	Lon protease (S16) C-terminal proteolytic domain
SCO2938	COG0667	Aldo Keto reductase
SCO2940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SCO2943	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SCO2944	COG0395	ABC-type sugar transport system, permease component
SCO2948	COG1678	Uncharacterized ACR, COG1678
SCO2949	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SCO2950	COG0776	regulation of translation
SCO2952	COG3973	AAA domain
SCO2959	COG2223	nitrite transmembrane transporter activity
SCO2964	COG0583	DNA-binding transcription factor activity
SCO2966	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SCO2967	COG0793	Belongs to the peptidase S41A family
SCO2969	COG2884	Cell division ATP-binding protein ftsE
SCO2972	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SCO2973	COG0515	serine threonine protein kinase
SCO2974	COG0515	serine threonine protein kinase
SCO2979	COG1175	transmembrane transport
SCO2980	COG0395	ABC-type sugar transport system, permease component
SCO2982	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SCO2983	COG1216	Glycosyl transferase, family 2
SCO2986	COG1764	response to oxidative stress
SCO2987	COG1846	Transcriptional regulator
SCO2996	COG1134	teichoic acid transport
SCO2996	COG1388	LysM domain
SCO2997	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SCO2998	COG1216	Glycosyl transferase, family 2
SCO2998	COG1442	glycosyl transferase family 8
SCO2999	COG2902	Dehydrogenase
SCO3005	COG0653	protein targeting
SCO3007	COG3214	Protein conserved in bacteria
SCO3008	COG2197	response regulator
SCO3009	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SCO3011	COG0823	Involved in the tonB-independent uptake of proteins
SCO3012	COG5000	phosphorelay sensor kinase activity
SCO3012	COG5002	protein histidine kinase activity
SCO3013	COG0745	RESPONSE REGULATOR receiver
SCO3014	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SCO3018	COG0714	Associated with various cellular activities
SCO3023	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SCO3025	COG1482	cell wall glycoprotein biosynthetic process
SCO3027	COG2835	tetraacyldisaccharide 4'-kinase activity
SCO3028	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SCO3029	COG1620	l-lactate permease
SCO3036	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SCO3037	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SCO3037	COG0778	Nitroreductase
SCO3042	COG1316	TRANSCRIPTIONal
SCO3043	COG1316	TRANSCRIPTIONal
SCO3044	COG1316	TRANSCRIPTIONal
SCO3045	COG1316	TRANSCRIPTIONal
SCO3046	COG1316	TRANSCRIPTIONal
SCO3047	COG1316	TRANSCRIPTIONal
SCO3048	COG1316	TRANSCRIPTIONal
SCO3052	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SCO3062	COG2205	protein histidine kinase activity
SCO3063	COG0745	RESPONSE REGULATOR receiver
SCO3064	COG3104	oligopeptide transport
SCO3067	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO3068	COG1191	sigma factor activity
SCO3070	COG1228	amidohydrolase
SCO3072	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SCO3073	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SCO3078	COG2755	lipolytic protein G-D-S-L family
SCO3079	COG0183	Belongs to the thiolase family
SCO3089	COG1136	(ABC) transporter
SCO3090	COG1136	(ABC) transporter
SCO3090	COG0577	efflux transmembrane transporter activity
SCO3091	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SCO3092	COG1252	NADH dehydrogenase
SCO3096	COG0148	phosphopyruvate hydratase activity
SCO3110	COG0577	efflux transmembrane transporter activity
SCO3111	COG1136	(ABC) transporter
SCO3119	COG4585	Histidine kinase
SCO3122	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SCO3123	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SCO3124	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SCO3125	COG0193	aminoacyl-tRNA hydrolase activity
SCO3127	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SCO3129	COG1309	transcriptional regulator
SCO3130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO3132	COG4106	trans-aconitate 2-methyltransferase activity
SCO3134	COG2197	response regulator
SCO3136	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SCO3147	COG0488	(ABC) transporter
SCO3148	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SCO3149	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SCO3151	COG0084	hydrolase, TatD family'
SCO3157	COG0768	penicillin binding
SCO3159	COG0310	cobalt ion transport
SCO3161	COG1122	ATPase activity
SCO3162	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SCO3165	COG0442	prolyl-tRNA aminoacylation
SCO3166	COG2409	Drug exporters of the RND superfamily
SCO3168	COG4946	Tricorn protease homolog
SCO3168	COG0793	Belongs to the peptidase S41A family
SCO3171	COG2267	carboxylic ester hydrolase activity
SCO3172	COG2072	flavoprotein involved in K transport
SCO3174	COG0708	Exodeoxyribonuclease III
SCO3178	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO3179	COG0521	Mo-molybdopterin cofactor biosynthetic process
SCO3179	COG0315	cyclic pyranopterin monophosphate synthase activity
SCO3180	COG0315	cyclic pyranopterin monophosphate synthase activity
SCO3182	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SCO3183	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SCO3188	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SCO3196	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SCO3196	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SCO3196	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SCO3198	COG1349	DNA-binding transcription factor activity
SCO3199	COG0477	Major facilitator Superfamily
SCO3202	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SCO3203	COG1247	-acetyltransferase
SCO3204	COG3384	dioxygenase
SCO3205	COG1846	Transcriptional regulator
SCO3209	COG1414	Transcriptional regulator
SCO3210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SCO3211	COG0134	indole-3-glycerol-phosphate synthase activity
SCO3212	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SCO3213	COG0512	Glutamine amidotransferase of anthranilate synthase
SCO3213	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SCO3214	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SCO3216	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SCO3217	COG3629	intracellular signal transduction
SCO3217	COG3903	Transcriptional regulator
SCO3225	COG4585	Histidine kinase
SCO3226	COG2197	response regulator
SCO3231	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SCO3232	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SCO3234	COG0510	thiamine kinase activity
SCO3235	COG1132	(ABC) transporter
SCO3236	COG2175	clavaminate synthase activity
SCO3242	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SCO3246	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCO3248	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO3249	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO3250	COG0582	viral genome integration into host DNA
SCO3275	COG0789	Transcriptional regulator
SCO3276	COG0659	secondary active sulfate transmembrane transporter activity
SCO3279	COG0569	domain protein
SCO3279	COG0475	glutathione-regulated potassium exporter activity
SCO3284	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO3284	COG2208	phosphoserine phosphatase activity
SCO3284	COG2172	sigma factor antagonist activity
SCO3296	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO3297	COG1742	UPF0060 membrane protein
SCO3299	COG1690	Belongs to the RtcB family
SCO3303	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SCO3304	COG0018	arginyl-trna synthetase
SCO3305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SCO3306	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SCO3311	COG0113	porphobilinogen synthase activity
SCO3314	COG0604	alcohol dehydrogenase
SCO3314	COG3321	synthase
SCO3316	COG1028	Short-chain dehydrogenase reductase Sdr
SCO3317	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SCO3317	COG1648	precorrin-2 dehydrogenase activity
SCO3318	COG0181	hydroxymethylbilane synthase activity
SCO3319	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SCO3320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SCO3330	COG0123	including yeast histone deacetylase and acetoin utilization protein
SCO3331	COG2223	nitrite transmembrane transporter activity
SCO3333	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCO3334	COG0180	Tryptophanyl-tRNA synthetase
SCO3336	COG1335	isochorismatase
SCO3337	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SCO3339	COG0842	Transport permease protein
SCO3339	COG1129	ABC transporter
SCO3344	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO3344	COG0515	serine threonine protein kinase
SCO3345	COG0129	dihydroxy-acid dehydratase activity
SCO3347	COG1082	Xylose isomerase domain protein TIM barrel
SCO3348	COG0248	Ppx GppA phosphatase
SCO3352	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SCO3355	COG1194	a g-specific adenine glycosylase
SCO3356	COG1595	DNA-templated transcription, initiation
SCO3358	COG0745	RESPONSE REGULATOR receiver
SCO3359	COG2205	protein histidine kinase activity
SCO3368	COG0739	heme binding
SCO3376	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SCO3380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SCO3382	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SCO3383	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SCO3388	COG1660	Displays ATPase and GTPase activities
SCO3392	COG0649	NAD binding
SCO3397	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SCO3397	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SCO3400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SCO3403	COG0302	gtp cyclohydrolase
SCO3406	COG0037	tRNA processing
SCO3408	COG2027	D-alanyl-D-alanine carboxypeptidase
SCO3409	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SCO3411	COG0586	Pfam SNARE associated Golgi protein
SCO3412	COG0393	Putative heavy-metal-binding
SCO3413	COG0789	Transcriptional regulator
SCO3416	COG0076	glutamate decarboxylase activity
SCO3420	COG1012	belongs to the aldehyde dehydrogenase family
SCO3425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SCO3427	COG0254	rRNA binding
SCO3428	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SCO3429	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SCO3430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SCO3434	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SCO3434	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SCO3435	COG0583	DNA-binding transcription factor activity
SCO3436	COG0318	PFAM AMP-dependent synthetase and ligase
SCO3440	COG2132	Multicopper oxidase
SCO3443	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCO3444	COG3387	PFAM Glycoside hydrolase 15-related
SCO3450	COG1595	DNA-templated transcription, initiation
SCO3452	COG2226	methyltransferase
SCO3456	COG4134	Bacterial extracellular solute-binding protein
SCO3457	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SCO3458	COG0398	Pfam SNARE associated Golgi protein
SCO3460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCO3471	COG2273	Hydrolase Family 16
SCO3473	COG0800	Aldolase
SCO3475	COG4948	Mandelate Racemase Muconate Lactonizing
SCO3476	COG1028	Short-chain dehydrogenase reductase Sdr
SCO3478	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SCO3479	COG3250	beta-galactosidase activity
SCO3480	COG4948	Mandelate Racemase Muconate Lactonizing
SCO3482	COG0395	ABC-type sugar transport system, permease component
SCO3483	COG1175	transmembrane transport
SCO3484	COG1653	transport
SCO3485	COG1609	Transcriptional regulator
SCO3486	COG1012	belongs to the aldehyde dehydrogenase family
SCO3493	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO3495	COG0800	Aldolase
SCO3502	COG1028	Short-chain dehydrogenase reductase Sdr
SCO3503	COG0395	ABC-type sugar transport system, permease component
SCO3504	COG1175	transmembrane transport
SCO3505	COG2182	Extracellular solute-binding protein
SCO3506	COG1609	Transcriptional regulator
SCO3528	COG0305	Participates in initiation and elongation during chromosome replication
SCO3541	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SCO3542	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SCO3543	COG1754	DNA topoisomerase type I activity
SCO3543	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SCO3547	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SCO3548	COG2172	sigma factor antagonist activity
SCO3549	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO3550	COG1111	helicase
SCO3550	COG1205	dead DEAH box helicase
SCO3562	COG0659	secondary active sulfate transmembrane transporter activity
SCO3563	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SCO3564	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCO3566	COG2267	carboxylic ester hydrolase activity
SCO3568	COG0494	nUDIX hydrolase
SCO3572	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCO3574	COG0596	Alpha beta hydrolase
SCO3578	COG0003	Pfam Anion-transporting ATPase
SCO3580	COG4499	WXG100 protein secretion system (Wss), protein YukC
SCO3580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SCO3582	COG1408	metallophosphoesterase
SCO3589	COG2205	protein histidine kinase activity
SCO3590	COG0745	RESPONSE REGULATOR receiver
SCO3595	COG1181	Belongs to the D-alanine--D-alanine ligase family
SCO3596	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SCO3597	COG1234	tRNA 3'-trailer cleavage
SCO3602	COG0475	glutathione-regulated potassium exporter activity
SCO3603	COG3263	regulation of cellular component size
SCO3607	COG2268	Band 7 protein
SCO3608	COG1585	Membrane protein implicated in regulation of membrane protease activity
SCO3613	COG1595	DNA-templated transcription, initiation
SCO3618	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SCO3619	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SCO3622	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SCO3623	COG1802	Transcriptional regulator
SCO3629	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SCO3633	COG1131	(ABC) transporter
SCO3634	COG3559	Exporter of polyketide antibiotics
SCO3636	COG2124	cytochrome p450
SCO3638	COG2197	response regulator
SCO3639	COG4585	Histidine kinase
SCO3640	COG2197	response regulator
SCO3641	COG4585	Histidine kinase
SCO3645	COG3844	kynureninase activity
SCO3648	COG0477	Major facilitator Superfamily
SCO3649	COG0191	fructose-bisphosphate aldolase activity
SCO3650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SCO3653	COG2197	response regulator
SCO3654	COG4585	Histidine kinase
SCO3655	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SCO3661	COG0542	response to heat
SCO3667	COG4213	ABC transporter substrate-binding protein
SCO3668	COG0789	Transcriptional regulator
SCO3669	COG0484	heat shock protein binding
SCO3670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SCO3671	COG0443	Heat shock 70 kDa protein
SCO3672	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SCO3673	COG2181	nitrate reductase activity
SCO3673	COG0247	lactate metabolic process
SCO3677	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SCO3678	COG0717	Belongs to the dCTP deaminase family
SCO3690	COG0596	Alpha beta hydrolase
SCO3696	COG0640	Transcriptional regulator
SCO3697	COG2072	flavoprotein involved in K transport
SCO3698	COG0798	PFAM Bile acid sodium symporter
SCO3699	COG0640	Transcriptional regulator
SCO3700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SCO3701	COG0492	ferredoxin-NADP+ reductase activity
SCO3716	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SCO3717	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SCO3718	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SCO3721	COG0288	reversible hydration of carbon dioxide
SCO3730	COG0667	Aldo Keto reductase
SCO3731	COG1278	Cold shock
SCO3732	COG0513	Belongs to the DEAD box helicase family
SCO3739	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SCO3740	COG5002	protein histidine kinase activity
SCO3741	COG0745	RESPONSE REGULATOR receiver
SCO3744	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SCO3748	COG1278	Cold shock
SCO3750	COG4585	Histidine kinase
SCO3752	COG0577	efflux transmembrane transporter activity
SCO3752	COG1136	(ABC) transporter
SCO3755	COG1136	(ABC) transporter
SCO3755	COG0577	efflux transmembrane transporter activity
SCO3756	COG2197	response regulator
SCO3757	COG4585	Histidine kinase
SCO3758	COG3239	Fatty acid desaturase
SCO3773	COG0583	DNA-binding transcription factor activity
SCO3778	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SCO3779	COG1957	nucleoside hydrolase
SCO3780	COG0366	Alpha amylase catalytic
SCO3792	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCO3794	COG1215	transferase activity, transferring glycosyl groups
SCO3795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SCO3798	COG1741	Belongs to the pirin family
SCO3800	COG1960	acyl-CoA dehydrogenase activity
SCO3801	COG1362	aminopeptidase activity
SCO3815	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCO3816	COG0022	dehydrogenase e1 component
SCO3820	COG0515	serine threonine protein kinase
SCO3821	COG0515	serine threonine protein kinase
SCO3823	COG3321	synthase
SCO3823	COG1028	Short-chain dehydrogenase reductase Sdr
SCO3823	COG0604	alcohol dehydrogenase
SCO3832	COG1522	sequence-specific DNA binding
SCO3833	COG1309	transcriptional regulator
SCO3834	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO3843	COG1716	ATPase activity
SCO3844	COG1716	ATPase activity
SCO3847	COG0768	penicillin binding
SCO3848	COG0515	serine threonine protein kinase
SCO3849	COG3764	Sortase (surface protein transpeptidase)
SCO3850	COG3764	Sortase (surface protein transpeptidase)
SCO3855	COG0705	Rhomboid family
SCO3858	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SCO3860	COG0515	serine threonine protein kinase
SCO3869	COG2319	Wd-40 repeat
SCO3869	COG4249	Peptidase C14 caspase catalytic subunit p20
SCO3869	COG4249	Peptidase C14 caspase catalytic subunit p20
SCO3869	COG2319	Wd-40 repeat
SCO3873	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SCO3874	COG0187	DNA topoisomerase II activity
SCO3875	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SCO3876	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SCO3877	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SCO3878	COG0592	DNA-directed DNA polymerase activity
SCO3879	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SCO3880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SCO3881	COG0594	ribonuclease P activity
SCO3882	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SCO3883	COG0706	membrane insertase activity
SCO3885	COG0357	Ribosomal RNA small subunit methyltransferase G
SCO3886	COG1192	Involved in chromosome partitioning
SCO3889	COG3118	belongs to the thioredoxin family
SCO3890	COG0492	ferredoxin-NADP+ reductase activity
SCO3892	COG1595	DNA-templated transcription, initiation
SCO3896	COG0617	tRNA 3'-terminal CCA addition
SCO3901	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SCO3906	COG0360	Binds together with S18 to 16S ribosomal RNA
SCO3907	COG0629	single-stranded DNA binding
SCO3908	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SCO3909	COG0359	binds to the 23S rRNA
SCO3911	COG0305	Participates in initiation and elongation during chromosome replication
SCO3915	COG2814	Major facilitator Superfamily
SCO3920	COG0626	cystathionine gamma-synthase activity
SCO3921	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SCO3922	COG1950	PFAM Membrane protein of
SCO3923	COG0662	Cupin 2, conserved barrel domain protein
SCO3928	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SCO3932	COG2186	Transcriptional regulator
SCO3938	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SCO3943	COG1609	Transcriptional regulator
SCO3944	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SCO3945	COG1271	oxidase subunit
SCO3946	COG1294	oxidase, subunit
SCO3947	COG4988	ABC transporter
SCO3949	COG0739	heme binding
SCO3950	COG0561	phosphatase activity
SCO3953	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SCO3956	COG1131	(ABC) transporter
SCO3960	COG0561	phosphatase activity
SCO3961	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SCO3962	COG0077	Prephenate dehydratase
SCO3963	COG2837	iron assimilation
SCO3966	COG1999	signal sequence binding
SCO3970	COG0006	proline dipeptidase activity
SCO3974	COG0653	protein targeting
SCO3977	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCO3978	COG0604	alcohol dehydrogenase
SCO3978	COG3321	synthase
SCO3979	COG1309	transcriptional regulator
SCO4005	COG1595	DNA-templated transcription, initiation
SCO4006	COG0318	PFAM AMP-dependent synthetase and ligase
SCO4007	COG2814	Major facilitator Superfamily
SCO4008	COG1309	transcriptional regulator
SCO4009	COG0784	Response regulator, receiver
SCO4013	COG0768	penicillin binding
SCO4014	COG1733	regulation of RNA biosynthetic process
SCO4020	COG0745	RESPONSE REGULATOR receiver
SCO4021	COG2205	protein histidine kinase activity
SCO4023	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SCO4024	COG0477	Major facilitator Superfamily
SCO4026	COG3467	pyridoxamine 5'-phosphate
SCO4031	COG0477	Major facilitator Superfamily
SCO4034	COG1191	sigma factor activity
SCO4035	COG1191	sigma factor activity
SCO4041	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SCO4057	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SCO4068	COG0151	Belongs to the GarS family
SCO4071	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SCO4072	COG2197	response regulator
SCO4077	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SCO4078	COG0047	phosphoribosylformylglycinamidine synthase activity
SCO4079	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SCO4087	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SCO4089	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SCO4092	COG1643	Atp-dependent helicase
SCO4096	COG0513	Belongs to the DEAD box helicase family
SCO4098	COG0110	maltose O-acetyltransferase activity
SCO4104	COG2860	membrane
SCO4106	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SCO4106	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SCO4111	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SCO4113	COG0579	oxidoreductase
SCO4123	COG2197	response regulator
SCO4124	COG4585	Histidine kinase
SCO4132	COG1196	nuclear chromosome segregation
SCO4132	COG0739	heme binding
SCO4132	COG0741	lytic transglycosylase activity
SCO4133	COG0671	phosphoesterase, PA-phosphatase related
SCO4134	COG0277	FAD linked oxidase domain protein
SCO4136	COG1937	Protein conserved in bacteria
SCO4138	COG0306	phosphate transporter
SCO4139	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SCO4143	COG0494	nUDIX hydrolase
SCO4143	COG0406	alpha-ribazole phosphatase activity
SCO4145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SCO4151	COG0456	acetyltransferase
SCO4152	COG0737	Belongs to the 5'-nucleotidase family
SCO4153	COG1733	regulation of RNA biosynthetic process
SCO4156	COG0745	RESPONSE REGULATOR receiver
SCO4157	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCO4158	COG1609	Transcriptional regulator
SCO4159	COG0745	RESPONSE REGULATOR receiver
SCO4179	COG3485	protocatechuate 3,4-dioxygenase
SCO4180	COG0735	belongs to the Fur family
SCO4181	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SCO4182	COG1490	D-aminoacyl-tRNA deacylase activity
SCO4183	COG2801	Transposase and inactivated derivatives
SCO4183	COG3415	Transposase
SCO4186	COG4552	Acetyltransferase involved in intracellular survival and related
SCO4188	COG2188	Transcriptional regulator
SCO4190	COG2188	Transcriptional regulator
SCO4191	COG0546	phosphoglycolate phosphatase activity
SCO4196	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SCO4204	COG0438	transferase activity, transferring glycosyl groups
SCO4209	COG0588	phosphoglycerate mutase activity
SCO4211	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SCO4215	COG2188	Transcriptional regulator
SCO4223	COG3708	Transcriptional regulator
SCO4223	COG2207	Transcriptional regulator
SCO4229	COG5002	protein histidine kinase activity
SCO4232	COG1329	Transcriptional regulator
SCO4233	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SCO4234	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SCO4235	COG0215	cysteine-tRNA ligase activity
SCO4240	COG3842	ATPase activity
SCO4259	COG0464	growth
SCO4263	COG1672	PFAM Archaeal ATPase
SCO4263	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SCO4270	COG1309	transcriptional regulator
SCO4272	COG0494	nUDIX hydrolase
SCO4276	COG2197	response regulator
SCO4278	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SCO4283	COG1105	Belongs to the carbohydrate kinase PfkB family
SCO4285	COG1940	carbohydrate kinase activity
SCO4292	COG0463	Glycosyl transferase, family 2
SCO4295	COG1278	Cold shock
SCO4296	COG0459	protein refolding
SCO4303	COG1309	transcriptional regulator
SCO4304	COG1028	Short-chain dehydrogenase reductase Sdr
SCO4307	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SCO4316	COG3973	AAA domain
SCO4325	COG1278	Cold shock
SCO4326	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SCO4327	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SCO4329	COG2814	Major facilitator Superfamily
SCO4332	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SCO4334	COG2252	PERMEase
SCO4339	COG0667	Aldo Keto reductase
SCO4352	COG0667	Aldo Keto reductase
SCO4353	COG0667	Aldo Keto reductase
SCO4363	COG2197	response regulator
SCO4366	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SCO4367	COG0247	lactate metabolic process
SCO4367	COG0277	FAD linked oxidase domain protein
SCO4370	COG3415	Transposase
SCO4370	COG2801	Transposase and inactivated derivatives
SCO4371	COG2318	DinB family
SCO4377	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO4377	COG0515	serine threonine protein kinase
SCO4380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SCO4383	COG0318	PFAM AMP-dependent synthetase and ligase
SCO4387	COG0259	pyridoxamine-phosphate oxidase activity
SCO4391	COG1733	regulation of RNA biosynthetic process
SCO4393	COG4821	SIS domain
SCO4395	COG0596	Alpha beta hydrolase
SCO4395	COG2945	thiolester hydrolase activity
SCO4409	COG1595	DNA-templated transcription, initiation
SCO4414	COG2271	Major facilitator Superfamily
SCO4416	COG2072	flavoprotein involved in K transport
SCO4418	COG0259	pyridoxamine-phosphate oxidase activity
SCO4421	COG1309	transcriptional regulator
SCO4423	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO4423	COG0515	serine threonine protein kinase
SCO4426	COG3629	intracellular signal transduction
SCO4426	COG3903	Transcriptional regulator
SCO4429	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SCO4439	COG1686	Belongs to the peptidase S11 family
SCO4444	COG0386	Belongs to the glutathione peroxidase family
SCO4449	COG4257	antibiotic catabolic process
SCO4450	COG1309	transcriptional regulator
SCO4451	COG0477	Major facilitator Superfamily
SCO4452	COG4941	Belongs to the sigma-70 factor family
SCO4453	COG3795	YCII-related domain
SCO4461	COG3226	Transcriptional regulator
SCO4462	COG0738	Major facilitator superfamily
SCO4464	COG1535	isochorismatase
SCO4464	COG3433	isochorismatase activity
SCO4469	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SCO4470	COG0406	alpha-ribazole phosphatase activity
SCO4472	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCO4473	COG0785	Cytochrome C biogenesis protein
SCO4474	COG1333	cytochrome c biogenesis protein
SCO4475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SCO4482	COG0583	DNA-binding transcription factor activity
SCO4488	COG0515	serine threonine protein kinase
SCO4488	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO4490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SCO4491	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SCO4492	COG0163	prenyltransferase activity
SCO4494	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SCO4495	COG1573	uracil-dna glycosylase
SCO4498	COG1301	dicarboxylic acid transport
SCO4499	COG1309	transcriptional regulator
SCO4502	COG0183	Belongs to the thiolase family
SCO4505	COG1278	Cold shock
SCO4506	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SCO4507	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO4507	COG0515	serine threonine protein kinase
SCO4526	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SCO4550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SCO4556	COG2226	methyltransferase
SCO4560	COG0242	peptide deformylase activity
SCO4563	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4564	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4565	COG0649	NAD binding
SCO4567	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SCO4568	COG1034	ATP synthesis coupled electron transport
SCO4569	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SCO4570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4571	COG0839	Belongs to the complex I subunit 6 family
SCO4572	COG0713	ATP synthesis coupled electron transport
SCO4573	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SCO4575	COG1007	ATP synthesis coupled electron transport
SCO4577	COG0514	ATP-dependent DNA helicase (RecQ)
SCO4581	COG0561	phosphatase activity
SCO4583	COG0142	geranyltranstransferase activity
SCO4585	COG1131	(ABC) transporter
SCO4587	COG0655	NAD(P)H dehydrogenase (quinone) activity
SCO4593	COG0702	epimerase
SCO4594	COG1013	pyruvate-flavodoxin oxidoreductase activity
SCO4595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SCO4595	COG0674	pyruvate-flavodoxin oxidoreductase activity
SCO4598	COG4585	Histidine kinase
SCO4599	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4601	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4602	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SCO4603	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCO4605	COG0713	ATP synthesis coupled electron transport
SCO4606	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SCO4608	COG1007	ATP synthesis coupled electron transport
SCO4609	COG0501	Belongs to the peptidase M48B family
SCO4610	COG3304	Inner membrane component domain
SCO4613	COG2261	transglycosylase associated protein
SCO4614	COG1666	GTP binding
SCO4628	COG2188	Transcriptional regulator
SCO4629	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SCO4632	COG3629	intracellular signal transduction
SCO4632	COG3903	Transcriptional regulator
SCO4633	COG0702	epimerase
SCO4634	COG0402	S-adenosylhomocysteine deaminase activity
SCO4635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SCO4636	COG2030	dehydratase
SCO4641	COG0477	Major facilitator Superfamily
SCO4643	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SCO4644	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SCO4645	COG0436	Aminotransferase
SCO4646	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SCO4647	COG0250	Participates in transcription elongation, termination and antitermination
SCO4648	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SCO4649	COG0081	regulation of translation
SCO4652	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SCO4653	COG0222	ribosome binding
SCO4654	COG0085	RNA polymerase activity
SCO4655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SCO4658	COG0463	Glycosyl transferase, family 2
SCO4659	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SCO4660	COG0049	tRNA binding
SCO4661	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SCO4662	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SCO4666	COG0577	efflux transmembrane transporter activity
SCO4666	COG1136	(ABC) transporter
SCO4668	COG2197	response regulator
SCO4681	COG1028	Short-chain dehydrogenase reductase Sdr
SCO4683	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SCO4684	COG1278	Cold shock
SCO4685	COG0513	Belongs to the DEAD box helicase family
SCO4698	COG2801	Transposase and inactivated derivatives
SCO4698	COG3415	Transposase
SCO4701	COG0051	transcription antitermination factor activity, RNA binding
SCO4702	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SCO4703	COG0088	Forms part of the polypeptide exit tunnel
SCO4704	COG0089	rRNA binding
SCO4705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SCO4706	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SCO4707	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SCO4708	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SCO4709	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SCO4710	COG0255	Belongs to the universal ribosomal protein uL29 family
SCO4711	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SCO4712	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SCO4713	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SCO4714	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SCO4715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SCO4716	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SCO4717	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SCO4718	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SCO4719	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SCO4720	COG1841	ribosomal large subunit assembly
SCO4721	COG0200	Binds to the 23S rRNA
SCO4722	COG0201	protein transport
SCO4723	COG0563	adenylate kinase activity
SCO4725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SCO4726	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SCO4727	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SCO4728	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SCO4729	COG0202	RNA polymerase activity
SCO4730	COG0203	ribosomal protein L17
SCO4731	COG0101	tRNA pseudouridine synthase activity
SCO4734	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SCO4735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SCO4736	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SCO4738	COG1072	(Pantothenic acid kinase))
SCO4740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SCO4744	COG0736	holo-[acyl-carrier-protein] synthase activity
SCO4745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SCO4747	COG0802	atpase or kinase
SCO4750	COG1214	PFAM Peptidase M22, glycoprotease
SCO4750	COG0456	acetyltransferase
SCO4752	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SCO4755	COG1316	TRANSCRIPTIONal
SCO4757	COG4941	Belongs to the sigma-70 factor family
SCO4759	COG0726	polysaccharide deacetylase
SCO4760	COG0726	polysaccharide deacetylase
SCO4761	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SCO4762	COG0459	protein refolding
SCO4764	COG4221	oxidoreductase activity
SCO4766	COG0583	DNA-binding transcription factor activity
SCO4769	COG1595	DNA-templated transcription, initiation
SCO4771	COG0516	GMP reductase activity
SCO4776	COG0515	serine threonine protein kinase
SCO4776	COG2815	serine threonine protein kinase
SCO4777	COG0515	serine threonine protein kinase
SCO4779	COG0515	serine threonine protein kinase
SCO4780	COG1012	belongs to the aldehyde dehydrogenase family
SCO4785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SCO4785	COG0519	Catalyzes the synthesis of GMP from XMP
SCO4792	COG2197	response regulator
SCO4793	COG0791	NLP P60 protein
SCO4798	COG0739	heme binding
SCO4800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO4800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO4803	COG0714	Associated with various cellular activities
SCO4804	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SCO4805	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SCO4808	COG0045	succinate-CoA ligase (ADP-forming) activity
SCO4814	COG0138	bifunctional purine biosynthesis protein purh
SCO4816	COG3409	Peptidoglycan-binding domain 1 protein
SCO4824	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SCO4827	COG0039	L-malate dehydrogenase activity
SCO4828	COG1012	belongs to the aldehyde dehydrogenase family
SCO4830	COG0517	IMP dehydrogenase activity
SCO4830	COG4175	Glycine betaine
SCO4834	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO4835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO4836	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SCO4837	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SCO4839	COG0180	Tryptophanyl-tRNA synthetase
SCO4843	COG0671	phosphoesterase, PA-phosphatase related
SCO4846	COG1295	ribonuclease BN
SCO4847	COG1686	Belongs to the peptidase S11 family
SCO4849	COG1408	metallophosphoesterase
SCO4850	COG1309	transcriptional regulator
SCO4856	COG1053	succinate dehydrogenase
SCO4858	COG2009	succinate dehydrogenase
SCO4864	COG1595	DNA-templated transcription, initiation
SCO4866	COG1595	DNA-templated transcription, initiation
SCO4869	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO4869	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO4875	COG0463	Glycosyl transferase, family 2
SCO4878	COG1216	Glycosyl transferase, family 2
SCO4881	COG2089	acid synthase
SCO4883	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SCO4883	COG1473	amidohydrolase
SCO4884	COG1744	ABC transporter substrate-binding protein PnrA-like
SCO4885	COG1744	ABC transporter substrate-binding protein PnrA-like
SCO4886	COG3845	ABC transporter
SCO4888	COG1079	Belongs to the binding-protein-dependent transport system permease family
SCO4896	COG2814	Major facilitator Superfamily
SCO4897	COG0583	DNA-binding transcription factor activity
SCO4901	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SCO4906	COG2205	protein histidine kinase activity
SCO4907	COG0745	RESPONSE REGULATOR receiver
SCO4908	COG1595	DNA-templated transcription, initiation
SCO4911	COG0515	serine threonine protein kinase
SCO4912	COG1012	belongs to the aldehyde dehydrogenase family
SCO4913	COG1012	belongs to the aldehyde dehydrogenase family
SCO4916	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SCO4921	COG4770	biotin carboxylase activity
SCO4923	COG0424	maF-like protein
SCO4926	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SCO4928	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SCO4930	COG1024	Enoyl-CoA hydratase
SCO4932	COG2986	histidine ammonia-lyase
SCO4936	COG1136	(ABC) transporter
SCO4938	COG1595	DNA-templated transcription, initiation
SCO4939	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SCO4942	COG1309	transcriptional regulator
SCO4943	COG0667	Aldo Keto reductase
SCO4945	COG1064	alcohol dehydrogenase
SCO4946	COG1090	epimerase
SCO4948	COG1140	nitrate reductase beta subunit
SCO4951	COG0667	Aldo Keto reductase
SCO4956	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCO4960	COG1595	DNA-templated transcription, initiation
SCO4961	COG2255	four-way junction helicase activity
SCO4962	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SCO4965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SCO4967	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SCO4972	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SCO4974	COG0590	tRNA wobble adenosine to inosine editing
SCO4975	COG1331	Highly conserved protein containing a thioredoxin domain
SCO4977	COG1309	transcriptional regulator
SCO4979	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SCO4984	COG0436	Aminotransferase
SCO4986	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SCO4989	COG1414	Transcriptional regulator
SCO4990	COG0251	oxidation-reduction process
SCO4991	COG2610	gluconate transmembrane transporter activity
SCO5006	COG2894	cell division
SCO5026	COG2226	methyltransferase
SCO5028	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SCO5029	COG0741	lytic transglycosylase activity
SCO5031	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO5032	COG0450	alkyl hydroperoxide reductase
SCO5035	COG1136	(ABC) transporter
SCO5039	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SCO5042	COG0114	fumarate hydratase activity
SCO5044	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SCO5044	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SCO5049	COG0778	Nitroreductase
SCO5055	COG1722	exodeoxyribonuclease VII activity
SCO5056	COG1570	exodeoxyribonuclease VII activity
SCO5058	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SCO5061	COG0012	GTP binding
SCO5064	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SCO5066	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCO5069	COG0604	alcohol dehydrogenase
SCO5072	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO5076	COG0477	Major facilitator Superfamily
SCO5083	COG0477	Major facilitator Superfamily
SCO5084	COG2409	Drug exporters of the RND superfamily
SCO5085	COG3629	intracellular signal transduction
SCO5086	COG1028	Short-chain dehydrogenase reductase Sdr
SCO5087	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO5088	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO5089	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO5090	COG2867	negative regulation of translational initiation
SCO5092	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SCO5093	COG2318	DinB family
SCO5096	COG0583	DNA-binding transcription factor activity
SCO5097	COG0300	oxidoreductase activity
SCO5106	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SCO5107	COG1053	succinate dehydrogenase
SCO5111	COG1217	gtp-binding protein TYPA
SCO5112	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO5113	COG4166	transmembrane transport
SCO5115	COG0444	Belongs to the ABC transporter superfamily
SCO5116	COG4608	Belongs to the ABC transporter superfamily
SCO5118	COG0601	transmembrane transport
SCO5119	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO5120	COG0444	Belongs to the ABC transporter superfamily
SCO5121	COG4608	Belongs to the ABC transporter superfamily
SCO5126	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SCO5129	COG1131	(ABC) transporter
SCO5131	COG4585	Histidine kinase
SCO5132	COG2197	response regulator
SCO5139	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SCO5141	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SCO5143	COG0519	Catalyzes the synthesis of GMP from XMP
SCO5144	COG1024	Enoyl-CoA hydratase
SCO5147	COG1595	DNA-templated transcription, initiation
SCO5149	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCO5150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SCO5155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SCO5157	COG0598	Magnesium transport protein CorA
SCO5159	COG2814	Major facilitator Superfamily
SCO5161	COG0613	PHP domain protein
SCO5162	COG2095	MarC family integral membrane protein
SCO5164	COG1432	Conserved Protein
SCO5166	COG0513	Belongs to the DEAD box helicase family
SCO5179	COG0596	Alpha beta hydrolase
SCO5184	COG0210	DNA helicase
SCO5186	COG2816	NAD+ diphosphatase activity
SCO5192	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SCO5202	COG3480	Lon protease (S16) C-terminal proteolytic domain
SCO5204	COG1615	UPF0182 protein
SCO5208	COG0483	inositol monophosphate 1-phosphatase activity
SCO5210	COG2076	Multidrug Resistance protein
SCO5212	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SCO5214	COG2135	peptidase activity
SCO5216	COG1595	DNA-templated transcription, initiation
SCO5217	COG5662	AntiSigma factor
SCO5221	COG0242	peptide deformylase activity
SCO5223	COG2124	cytochrome p450
SCO5231	COG2188	Transcriptional regulator
SCO5232	COG2182	Extracellular solute-binding protein
SCO5233	COG1175	transmembrane transport
SCO5234	COG0395	ABC-type sugar transport system, permease component
SCO5235	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO5236	COG0363	glucosamine-6-phosphate deaminase activity
SCO5237	COG1028	Short-chain dehydrogenase reductase Sdr
SCO5241	COG1597	lipid kinase activity
SCO5249	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SCO5250	COG0142	geranyltranstransferase activity
SCO5257	COG4106	trans-aconitate 2-methyltransferase activity
SCO5258	COG1126	abc transporter atp-binding protein
SCO5261	COG0281	malic enzyme
SCO5262	COG0604	alcohol dehydrogenase
SCO5277	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SCO5281	COG0567	Dehydrogenase, E1 component
SCO5281	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCO5282	COG2205	protein histidine kinase activity
SCO5283	COG0745	RESPONSE REGULATOR receiver
SCO5285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SCO5294	COG0791	NLP P60 protein
SCO5294	COG3883	PFAM NLP P60 protein
SCO5296	COG1309	transcriptional regulator
SCO5304	COG2205	protein histidine kinase activity
SCO5308	COG3285	dna ligase
SCO5308	COG1793	dna ligase
SCO5309	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SCO5312	COG3467	pyridoxamine 5'-phosphate
SCO5315	COG2867	negative regulation of translational initiation
SCO5316	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO5317	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO5318	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCO5319	COG0662	Cupin 2, conserved barrel domain protein
SCO5320	COG2329	Antibiotic biosynthesis monooxygenase
SCO5321	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO5351	COG0745	RESPONSE REGULATOR receiver
SCO5352	COG0018	arginyl-trna synthetase
SCO5353	COG0019	diaminopimelate decarboxylase activity
SCO5354	COG0460	homoserine dehydrogenase
SCO5355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SCO5356	COG0083	homoserine kinase activity
SCO5358	COG1316	TRANSCRIPTIONal
SCO5359	COG0254	rRNA binding
SCO5360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SCO5361	COG2890	protein-(glutamine-N5) methyltransferase activity
SCO5364	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SCO5368	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SCO5369	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SCO5370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SCO5371	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SCO5372	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SCO5373	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SCO5374	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SCO5377	COG2197	response regulator
SCO5378	COG4585	Histidine kinase
SCO5385	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO5388	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SCO5395	COG1131	(ABC) transporter
SCO5399	COG0183	Belongs to the thiolase family
SCO5403	COG0745	RESPONSE REGULATOR receiver
SCO5415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO5415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO5416	COG4977	sequence-specific DNA binding
SCO5417	COG0604	alcohol dehydrogenase
SCO5417	COG3321	synthase
SCO5417	COG1028	Short-chain dehydrogenase reductase Sdr
SCO5424	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SCO5425	COG0857	belongs to the CobB CobQ family
SCO5425	COG0280	phosphate acetyltransferase
SCO5426	COG0205	6-phosphofructokinase activity
SCO5428	COG0395	ABC-type sugar transport system, permease component
SCO5430	COG1653	transport
SCO5433	COG3629	intracellular signal transduction
SCO5433	COG3903	Transcriptional regulator
SCO5434	COG4565	transcriptional regulatory protein
SCO5435	COG3290	protein histidine kinase activity
SCO5436	COG1301	dicarboxylic acid transport
SCO5438	COG3118	belongs to the thioredoxin family
SCO5438	COG0492	ferredoxin-NADP+ reductase activity
SCO5440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SCO5441	COG3281	Trehalose synthase
SCO5442	COG0366	Alpha amylase catalytic
SCO5443	COG0366	Alpha amylase catalytic
SCO5444	COG0058	SHG alpha-glucan phosphorylase activity
SCO5448	COG1132	(ABC) transporter
SCO5449	COG2274	protein secretion by the type I secretion system
SCO5450	COG1132	(ABC) transporter
SCO5451	COG1132	(ABC) transporter
SCO5452	COG1131	(ABC) transporter
SCO5454	COG4585	Histidine kinase
SCO5458	COG1376	ErfK ybiS ycfS ynhG family protein
SCO5463	COG0789	Transcriptional regulator
SCO5465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SCO5466	COG3409	Peptidoglycan-binding domain 1 protein
SCO5466	COG3757	hydrolase, family 25
SCO5468	COG0477	Major facilitator Superfamily
SCO5469	COG1760	l-serine dehydratase
SCO5470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SCO5471	COG0509	glycine decarboxylation via glycine cleavage system
SCO5472	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SCO5476	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO5477	COG4166	transmembrane transport
SCO5479	COG0444	Belongs to the ABC transporter superfamily
SCO5480	COG4608	Belongs to the ABC transporter superfamily
SCO5481	COG2860	membrane
SCO5488	COG0482	sulfurtransferase activity
SCO5491	COG1611	Belongs to the LOG family
SCO5492	COG4221	oxidoreductase activity
SCO5494	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SCO5498	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SCO5499	COG0154	amidase activity
SCO5501	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SCO5502	COG2409	Drug exporters of the RND superfamily
SCO5503	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO5506	COG2197	response regulator
SCO5508	COG2133	pyrroloquinoline quinone binding
SCO5509	COG0667	Aldo Keto reductase
SCO5511	COG5001	Diguanylate cyclase
SCO5513	COG0440	acetolactate synthase activity
SCO5514	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SCO5515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SCO5516	COG0477	Major facilitator Superfamily
SCO5518	COG2508	Transcriptional regulator
SCO5519	COG0506	proline dehydrogenase activity
SCO5520	COG1012	belongs to the aldehyde dehydrogenase family
SCO5522	COG0473	3-isopropylmalate dehydrogenase activity
SCO5523	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SCO5525	COG0831	urea catabolic process
SCO5525	COG0832	Belongs to the urease beta subunit family
SCO5526	COG0804	urea catabolic process
SCO5527	COG2957	Belongs to the agmatine deiminase family
SCO5529	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SCO5533	COG2353	YceI-like domain
SCO5535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SCO5539	COG2018	Roadblock/LC7 domain
SCO5543	COG2018	Roadblock/LC7 domain
SCO5544	COG5002	protein histidine kinase activity
SCO5546	COG0179	Fumarylacetoacetate (FAA) hydrolase
SCO5547	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SCO5552	COG1414	Transcriptional regulator
SCO5553	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SCO5554	COG0066	3-isopropylmalate dehydratase activity
SCO5556	COG0776	regulation of translation
SCO5557a	COG1920	GTP binding
SCO5559	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SCO5560	COG1181	Belongs to the D-alanine--D-alanine ligase family
SCO5563	COG0351	phosphomethylpyrimidine kinase
SCO5564	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SCO5565	COG1461	Dihydroxyacetone kinase
SCO5567	COG0742	ribosomal rna small subunit methyltransferase
SCO5568	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SCO5571	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SCO5572	COG0571	ribonuclease III activity
SCO5573	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SCO5574	COG1733	regulation of RNA biosynthetic process
SCO5576	COG1254	Belongs to the acylphosphatase family
SCO5577	COG1196	nuclear chromosome segregation
SCO5578	COG0477	Major facilitator Superfamily
SCO5585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SCO5587	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SCO5591	COG0228	four-way junction DNA binding
SCO5592	COG1837	Belongs to the UPF0109 family
SCO5593	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SCO5594	COG0336	Belongs to the RNA methyltransferase TrmD family
SCO5595	COG0335	large ribosomal subunit rRNA binding
SCO5596	COG0681	Belongs to the peptidase S26 family
SCO5598	COG0681	Belongs to the peptidase S26 family
SCO5599	COG0681	Belongs to the peptidase S26 family
SCO5602	COG0792	nuclease activity
SCO5611	COG1396	sequence-specific DNA binding
SCO5611	COG3800	Transcriptional regulator
SCO5621	COG1191	sigma factor activity
SCO5624	COG0052	Belongs to the universal ribosomal protein uS2 family
SCO5625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SCO5626	COG0528	UMP kinase activity
SCO5627	COG0233	cytoplasmic translational termination
SCO5628	COG0575	Belongs to the CDS family
SCO5629	COG3903	Transcriptional regulator
SCO5629	COG3629	intracellular signal transduction
SCO5641	COG2801	Transposase and inactivated derivatives
SCO5641	COG3415	Transposase
SCO5645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SCO5647	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SCO5648	COG3842	ATPase activity
SCO5655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SCO5657	COG1012	belongs to the aldehyde dehydrogenase family
SCO5662	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SCO5668	COG3842	ATPase activity
SCO5669	COG1176	ABC-type spermidine putrescine transport system, permease component I
SCO5670	COG1177	transmembrane transport
SCO5671	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SCO5678	COG2508	Transcriptional regulator
SCO5678	COG2508	Transcriptional regulator
SCO5679	COG1012	belongs to the aldehyde dehydrogenase family
SCO5684	COG2197	response regulator
SCO5687	COG4209	transmembrane transport
SCO5688	COG0395	ABC-type sugar transport system, permease component
SCO5694	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SCO5695	COG0750	zinc metalloprotease
SCO5696	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SCO5699	COG0442	prolyl-tRNA aminoacylation
SCO5703	COG0779	Required for maturation of 30S ribosomal subunits
SCO5706	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SCO5708	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SCO5709	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SCO5712	COG4608	Belongs to the ABC transporter superfamily
SCO5715	COG0601	transmembrane transport
SCO5716	COG0747	negative chemotaxis
SCO5717	COG0455	bacterial-type flagellum organization
SCO5722	COG1404	Belongs to the peptidase S8 family
SCO5731	COG1404	Belongs to the peptidase S8 family
SCO5734	COG1674	ftsk spoiiie
SCO5736	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SCO5737	COG1185	polyribonucleotide nucleotidyltransferase activity
SCO5738	COG0612	Peptidase, M16
SCO5739	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SCO5743	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SCO5744	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCO5745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SCO5747	COG2770	Histidine kinase
SCO5747	COG2208	phosphoserine phosphatase activity
SCO5748	COG2205	protein histidine kinase activity
SCO5748	COG0784	Response regulator, receiver
SCO5750	COG1674	ftsk spoiiie
SCO5752	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SCO5754	COG1058	Belongs to the CinA family
SCO5754	COG1546	Belongs to the CinA family
SCO5755	COG1396	sequence-specific DNA binding
SCO5756	COG0783	Belongs to the Dps family
SCO5760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SCO5761	COG1201	RNA secondary structure unwinding
SCO5762	COG1917	Cupin 2, conserved barrel domain protein
SCO5762	COG2207	Transcriptional regulator
SCO5767	COG0628	permease
SCO5769	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SCO5770	COG2137	regulation of response to DNA damage stimulus
SCO5771	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCO5774	COG0765	amino acid transport
SCO5775	COG0765	amino acid transport
SCO5776	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SCO5777	COG1126	abc transporter atp-binding protein
SCO5778	COG0745	RESPONSE REGULATOR receiver
SCO5779	COG2205	protein histidine kinase activity
SCO5784	COG3851	Histidine kinase
SCO5785	COG2197	response regulator
SCO5787	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SCO5791	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SCO5793	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SCO5794	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SCO5796	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SCO5803	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SCO5804	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SCO5805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SCO5808	COG0588	phosphoglycerate mutase activity
SCO5812	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SCO5819	COG2186	Transcriptional regulator
SCO5820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SCO5822	COG0187	DNA topoisomerase II activity
SCO5825	COG2197	response regulator
SCO5827	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCO5828	COG4565	transcriptional regulatory protein
SCO5829	COG3290	protein histidine kinase activity
SCO5832	COG0372	Belongs to the citrate synthase family
SCO5836	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SCO5837	COG0612	Peptidase, M16
SCO5840	COG1802	Transcriptional regulator
SCO5841	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SCO5845	COG1435	thymidine kinase activity
SCO5847	COG2188	Transcriptional regulator
SCO5849	COG2222	sugar isomerase
SCO5859	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SCO5862	COG0745	RESPONSE REGULATOR receiver
SCO5863	COG2205	protein histidine kinase activity
SCO5868	COG0756	dUTP diphosphatase activity
SCO5870	COG1136	(ABC) transporter
SCO5870	COG4591	ABC-type transport system involved in lipoprotein release permease component
SCO5876	COG0569	domain protein
SCO5877	COG3629	intracellular signal transduction
SCO5879	COG1960	acyl-CoA dehydrogenase activity
SCO5885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SCO5887	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO5888	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCO5889	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCO5890	COG0156	8-amino-7-oxononanoate synthase activity
SCO5891	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SCO5892	COG3321	synthase
SCO5892	COG0604	alcohol dehydrogenase
SCO5893	COG1088	dTDP-glucose 4,6-dehydratase activity
SCO5895	COG0500	methyltransferase
SCO5896	COG0574	Belongs to the PEP-utilizing enzyme family
SCO5896	COG3848	Pyruvate phosphate dikinase
SCO5900	COG0531	amino acid
SCO5901	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SCO5905	COG2409	Drug exporters of the RND superfamily
SCO5912	COG3291	Pkd domain containing protein
SCO5920	COG0513	Belongs to the DEAD box helicase family
SCO5921	COG1278	Cold shock
SCO5922	COG1028	Short-chain dehydrogenase reductase Sdr
SCO5923	COG3842	ATPase activity
SCO5924	COG1178	ABC-type Fe3 transport system permease component
SCO5926	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SCO5930	COG1051	belongs to the nudix hydrolase family
SCO5932	COG3693	PFAM glycoside hydrolase, family 10
SCO5940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SCO5941	COG0436	Aminotransferase
SCO5943	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SCO5945	COG0405	Gamma-glutamyltransferase
SCO5946	COG3619	membrane
SCO5953	COG2319	Wd-40 repeat
SCO5957	COG0477	Major facilitator Superfamily
SCO5958	COG1122	ATPase activity
SCO5960	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SCO5961	COG0310	cobalt ion transport
SCO5962	COG0789	Transcriptional regulator
SCO5963	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SCO5966	COG0277	FAD linked oxidase domain protein
SCO5966	COG0247	lactate metabolic process
SCO5967	COG1799	cell septum assembly
SCO5973	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SCO5975	COG2235	arginine
SCO5976	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SCO5977	COG0531	amino acid
SCO5979	COG1024	Enoyl-CoA hydratase
SCO5993	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCO5993	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SCO5994	COG0785	Cytochrome C biogenesis protein
SCO5996	COG2319	Wd-40 repeat
SCO5998	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SCO5999	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SCO6005	COG1653	transport
SCO6006	COG1175	transmembrane transport
SCO6007	COG0395	ABC-type sugar transport system, permease component
SCO6008	COG1940	carbohydrate kinase activity
SCO6009	COG4213	ABC transporter substrate-binding protein
SCO6011	COG4214	carbohydrate transport
SCO6012	COG3979	chitinase
SCO6013	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SCO6014	COG0531	amino acid
SCO6020	COG1316	TRANSCRIPTIONal
SCO6021	COG0438	transferase activity, transferring glycosyl groups
SCO6022	COG0438	transferase activity, transferring glycosyl groups
SCO6023	COG0438	transferase activity, transferring glycosyl groups
SCO6024	COG0438	transferase activity, transferring glycosyl groups
SCO6026	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO6026	COG1024	Enoyl-CoA hydratase
SCO6027	COG0183	Belongs to the thiolase family
SCO6028	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SCO6031	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SCO6032	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO6039	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCO6041	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SCO6042	COG3253	May function as heme-dependent peroxidase
SCO6045	COG3220	belongs to the UPF0276 family
SCO6047	COG1116	anion transmembrane transporter activity
SCO6051	COG0723	plastoquinol--plastocyanin reductase activity
SCO6051	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SCO6053	COG0330	HflC and HflK could
SCO6060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SCO6061	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCO6063	COG1174	glycine betaine transport
SCO6064	COG1174	glycine betaine transport
SCO6065	COG1732	Glycine betaine
SCO6071	COG1309	transcriptional regulator
SCO6075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SCO6077	COG3173	Aminoglycoside phosphotransferase
SCO6086	COG1175	transmembrane transport
SCO6089	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SCO6094	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SCO6095	COG1116	anion transmembrane transporter activity
SCO6099	COG0529	Catalyzes the synthesis of activated sulfate
SCO6100	COG0175	sulfate reduction
SCO6106	COG1960	acyl-CoA dehydrogenase activity
SCO6110	COG1940	carbohydrate kinase activity
SCO6115	COG1940	carbohydrate kinase activity
SCO6115	COG1846	Transcriptional regulator
SCO6117	COG3142	Participates in the control of copper homeostasis
SCO6118	COG4977	sequence-specific DNA binding
SCO6118	COG1917	Cupin 2, conserved barrel domain protein
SCO6120	COG2318	DinB family
SCO6131	COG2027	D-alanyl-D-alanine carboxypeptidase
SCO6134	COG0714	Associated with various cellular activities
SCO6137	COG2040	homocysteine
SCO6139	COG4585	Histidine kinase
SCO6140	COG2197	response regulator
SCO6147	COG0277	FAD linked oxidase domain protein
SCO6149	COG1162	GTPase activity
SCO6151	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SCO6155	COG0028	Belongs to the TPP enzyme family
SCO6159	COG1802	Transcriptional regulator
SCO6160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SCO6162	COG2197	response regulator
SCO6163	COG3851	Histidine kinase
SCO6169	COG3835	regulator
SCO6172	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SCO6173	COG2252	PERMEase
SCO6178	COG0726	polysaccharide deacetylase
SCO6179	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCO6180	COG2192	nodulation
SCO6182	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SCO6183	COG0859	PFAM glycosyl transferase family 9
SCO6184	COG0438	transferase activity, transferring glycosyl groups
SCO6185	COG0438	transferase activity, transferring glycosyl groups
SCO6186	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SCO6187	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SCO6187	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SCO6194	COG2197	response regulator
SCO6195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SCO6196	COG0318	PFAM AMP-dependent synthetase and ligase
SCO6201	COG3960	tartronate-semialdehyde synthase activity
SCO6204	COG0753	catalase activity
SCO6205	COG2084	Dehydrogenase
SCO6206	COG3622	Belongs to the hyi family
SCO6210	COG2351	hydroxyisourate hydrolase activity
SCO6212	COG2233	PERMEase
SCO6214	COG2233	PERMEase
SCO6218	COG0406	alpha-ribazole phosphatase activity
SCO6226	COG4264	IucA IucC family
SCO6229	COG3833	ABC-type maltose transport systems, permease component
SCO6230	COG1175	transmembrane transport
SCO6232	COG3250	beta-galactosidase activity
SCO6233	COG1609	Transcriptional regulator
SCO6239	COG1595	DNA-templated transcription, initiation
SCO6243	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SCO6246	COG1414	Transcriptional regulator
SCO6247	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SCO6248	COG4266	Belongs to the allantoicase family
SCO6249	COG1028	Short-chain dehydrogenase reductase Sdr
SCO6251	COG0431	NADPH-dependent FMN reductase
SCO6254	COG2197	response regulator
SCO6255	COG0673	inositol 2-dehydrogenase activity
SCO6256	COG2188	Transcriptional regulator
SCO6260	COG1940	carbohydrate kinase activity
SCO6262	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SCO6264	COG1028	Short-chain dehydrogenase reductase Sdr
SCO6267	COG0702	epimerase
SCO6269	COG1013	pyruvate-flavodoxin oxidoreductase activity
SCO6270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SCO6270	COG0674	pyruvate-flavodoxin oxidoreductase activity
SCO6271	COG4770	biotin carboxylase activity
SCO6274	COG0604	alcohol dehydrogenase
SCO6274	COG3321	synthase
SCO6277	COG0596	Alpha beta hydrolase
SCO6278	COG0477	Major facilitator Superfamily
SCO6284	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SCO6288	COG3629	intracellular signal transduction
SCO6289	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SCO6290	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCO6290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SCO6291	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCO6292	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCO6293	COG3938	Belongs to the proline racemase family
SCO6294	COG1802	Transcriptional regulator
SCO6295	COG1132	(ABC) transporter
SCO6297	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO6298	COG3246	L-lysine catabolic process to acetate
SCO6300	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO6303	COG0179	Fumarylacetoacetate (FAA) hydrolase
SCO6306	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO6320	COG0038	chloride channel
SCO6324	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCO6330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SCO6339	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO6344	COG0154	amidase activity
SCO6348	COG1470	cell adhesion involved in biofilm formation
SCO6348	COG0366	Alpha amylase catalytic
SCO6349	COG1609	Transcriptional regulator
SCO6355	COG0671	phosphoesterase, PA-phosphatase related
SCO6356	COG0671	phosphoesterase, PA-phosphatase related
SCO6357	COG0586	Pfam SNARE associated Golgi protein
SCO6362	COG4585	Histidine kinase
SCO6366	COG0577	efflux transmembrane transporter activity
SCO6366	COG1136	(ABC) transporter
SCO6367	COG1136	(ABC) transporter
SCO6369	COG2205	protein histidine kinase activity
SCO6374	COG0463	Glycosyl transferase, family 2
SCO6378	COG0671	phosphoesterase, PA-phosphatase related
SCO6379	COG0586	Pfam SNARE associated Golgi protein
SCO6384	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SCO6384	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SCO6385	COG0531	amino acid
SCO6391	COG3547	Transposase (IS116 IS110 IS902 family)
SCO6400	COG3547	Transposase (IS116 IS110 IS902 family)
SCO6401	COG2318	DinB family
SCO6407	COG0405	Gamma-glutamyltransferase
SCO6408	COG0542	response to heat
SCO6412	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SCO6415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SCO6416	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO6417	COG1953	Uracil, thiamine, allantoin
SCO6422	COG2197	response regulator
SCO6424	COG4585	Histidine kinase
SCO6426	COG1120	ATPase activity
SCO6429	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SCO6429	COG2308	Evidence 4 Homologs of previously reported genes of
SCO6434	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SCO6436	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCO6438	COG0019	diaminopimelate decarboxylase activity
SCO6439	COG1278	Cold shock
SCO6440	COG1891	lyase activity
SCO6443	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SCO6445	COG0483	inositol monophosphate 1-phosphatase activity
SCO6447	COG2249	NAD(P)H dehydrogenase (quinone) activity
SCO6450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SCO6452	COG0601	transmembrane transport
SCO6453	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO6454	COG0444	Belongs to the ABC transporter superfamily
SCO6455	COG1124	(ABC) transporter
SCO6459	COG0640	Transcriptional regulator
SCO6462	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SCO6464	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SCO6466	COG1929	Belongs to the glycerate kinase type-1 family
SCO6468	COG0688	phosphatidylethanolamine metabolic process
SCO6469	COG1960	acyl-CoA dehydrogenase activity
SCO6471	COG2301	Belongs to the HpcH HpaI aldolase family
SCO6472	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO6472	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO6473	COG0604	alcohol dehydrogenase
SCO6475	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO6479	COG0596	Alpha beta hydrolase
SCO6484	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO6484	COG2208	phosphoserine phosphatase activity
SCO6484	COG2172	sigma factor antagonist activity
SCO6486	COG2362	D-Aminopeptidase
SCO6487	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SCO6489	COG1619	proteins homologs of microcin C7 resistance protein MccF
SCO6495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO6498	COG3285	dna ligase
SCO6498	COG1793	dna ligase
SCO6511	COG1597	lipid kinase activity
SCO6515	COG0693	protein deglycase activity
SCO6517	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SCO6520	COG1191	sigma factor activity
SCO6528	COG0531	amino acid
SCO6534	COG1140	nitrate reductase beta subunit
SCO6540	COG2154	pterin-4-alpha-carbinolamine dehydratase
SCO6541	COG4106	trans-aconitate 2-methyltransferase activity
SCO6541	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SCO6542	COG3401	FG-GAP repeat protein
SCO6546	COG5297	Belongs to the glycosyl hydrolase family 6
SCO6546	COG4733	cellulase activity
SCO6548	COG5297	Belongs to the glycosyl hydrolase family 6
SCO6549	COG2226	methyltransferase
SCO6550	COG4221	oxidoreductase activity
SCO6551	COG0656	L-ascorbic acid biosynthetic process
SCO6553	COG0477	Major facilitator Superfamily
SCO6558	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SCO6560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SCO6561	COG3383	formate dehydrogenase (NAD+) activity
SCO6562	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SCO6564	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCO6567	COG1129	ABC transporter
SCO6568	COG1172	Belongs to the binding-protein-dependent transport system permease family
SCO6570	COG0673	inositol 2-dehydrogenase activity
SCO6581	COG2223	nitrite transmembrane transporter activity
SCO6583	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO6585	COG0045	succinate-CoA ligase (ADP-forming) activity
SCO6587	COG1012	belongs to the aldehyde dehydrogenase family
SCO6589	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SCO6601	COG2182	Extracellular solute-binding protein
SCO6602	COG1175	transmembrane transport
SCO6603	COG0395	ABC-type sugar transport system, permease component
SCO6604	COG2723	6-phospho-beta-galactosidase activity
SCO6608	COG5434	Belongs to the glycosyl hydrolase 28 family
SCO6608	COG4632	Exopolysaccharide biosynthesis protein
SCO6613	COG1733	regulation of RNA biosynthetic process
SCO6619	COG0300	oxidoreductase activity
SCO6633	COG3629	intracellular signal transduction
SCO6633	COG3903	Transcriptional regulator
SCO6640	COG1201	RNA secondary structure unwinding
SCO6644	COG0747	negative chemotaxis
SCO6645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO6647	COG1183	phosphatidylcholine synthase activity
SCO6651	COG0297	glycogen (starch) synthase activity
SCO6655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SCO6658	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SCO6659	COG0166	Belongs to the GPI family
SCO6662	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SCO6666	COG2409	Drug exporters of the RND superfamily
SCO6667	COG2197	response regulator
SCO6668	COG4585	Histidine kinase
SCO6670	COG1486	melibiose metabolic process
SCO6672	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SCO6681	COG0515	serine threonine protein kinase
SCO6683	COG1132	(ABC) transporter
SCO6684	COG1132	(ABC) transporter
SCO6685	COG2197	response regulator
SCO6690	COG0477	Major facilitator Superfamily
SCO6691	COG3511	phospholipase C
SCO6697	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SCO6698	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SCO6699	COG3485	protocatechuate 3,4-dioxygenase
SCO6700	COG3485	protocatechuate 3,4-dioxygenase
SCO6701	COG0183	Belongs to the thiolase family
SCO6705	COG1470	cell adhesion involved in biofilm formation
SCO6707	COG1793	dna ligase
SCO6718	COG1834	amidinotransferase
SCO6719	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SCO6720	COG0488	(ABC) transporter
SCO6726	COG1515	deoxyribonuclease V activity
SCO6729	COG3268	Saccharopine dehydrogenase
SCO6730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO6731	COG0183	Belongs to the thiolase family
SCO6732	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO6732	COG1024	Enoyl-CoA hydratase
SCO6734	COG1113	amino acid transport
SCO6739	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SCO6742	COG0488	(ABC) transporter
SCO6743	COG2183	response to ionizing radiation
SCO6748	COG1024	Enoyl-CoA hydratase
SCO6750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SCO6758	COG1134	teichoic acid transport
SCO6759	COG1562	ergosterol biosynthetic process
SCO6762	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SCO6764	COG1657	PFAM Prenyltransferase squalene oxidase
SCO6767	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SCO6768	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SCO6772	COG2365	Tyrosine phosphatase family
SCO6774	COG2755	lipolytic protein G-D-S-L family
SCO6777	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCO6781	COG1309	transcriptional regulator
SCO6785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SCO6786	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO6787	COG1960	acyl-CoA dehydrogenase activity
SCO6788	COG0183	Belongs to the thiolase family
SCO6789	COG1250	3-hydroxyacyl-CoA dehydrogenase
SCO6789	COG1024	Enoyl-CoA hydratase
SCO6790	COG1022	Amp-dependent synthetase and ligase
SCO6791	COG1960	acyl-CoA dehydrogenase activity
SCO6799	COG1063	alcohol dehydrogenase
SCO6800	COG0156	8-amino-7-oxononanoate synthase activity
SCO6801	COG0583	DNA-binding transcription factor activity
SCO6812	COG0640	Transcriptional regulator
SCO6813	COG0640	Transcriptional regulator
SCO6814	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SCO6815	COG0573	inorganic phosphate transmembrane transporter activity
SCO6818	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SCO6819	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SCO6820	COG3383	formate dehydrogenase (NAD+) activity
SCO6821	COG0504	CTP synthase activity
SCO6822	COG0477	Major facilitator Superfamily
SCO6824	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SCO6824	COG0028	Belongs to the TPP enzyme family
SCO6825	COG0586	Pfam SNARE associated Golgi protein
SCO6827	COG0604	alcohol dehydrogenase
SCO6827	COG1028	Short-chain dehydrogenase reductase Sdr
SCO6827	COG3321	synthase
SCO6830	COG0640	Transcriptional regulator
SCO6832	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO6832	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO6833	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SCO6834	COG0492	ferredoxin-NADP+ reductase activity
SCO6835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SCO6837	COG0798	PFAM Bile acid sodium symporter
SCO6838	COG2072	flavoprotein involved in K transport
SCO6843	COG0305	Participates in initiation and elongation during chromosome replication
SCO6865	COG0714	Associated with various cellular activities
SCO6928	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SCO6944	COG3387	PFAM Glycoside hydrolase 15-related
SCO6954	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SCO6954	COG2111	Na H antiporter
SCO6955	COG1006	Multisubunit Na H antiporter MnhC subunit
SCO6956	COG0651	ATP synthesis coupled electron transport
SCO6959	COG1320	monovalent cation:proton antiporter activity
SCO6962	COG0174	glutamine synthetase
SCO6966	COG2267	carboxylic ester hydrolase activity
SCO6967	COG0183	Belongs to the thiolase family
SCO6968	COG0318	PFAM AMP-dependent synthetase and ligase
SCO6974	COG2188	Transcriptional regulator
SCO6975	COG3962	Belongs to the TPP enzyme family
SCO6976	COG3718	enzyme involved in inositol metabolism
SCO6978	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCO6984	COG0673	inositol 2-dehydrogenase activity
SCO6986	COG1609	Transcriptional regulator
SCO6987	COG3548	integral membrane protein
SCO6988	COG0673	inositol 2-dehydrogenase activity
SCO6990	COG0385	Bile acid
SCO6993	COG2197	response regulator
SCO6998	COG2124	cytochrome p450
SCO7000	COG2838	Isocitrate dehydrogenase
SCO7001	COG0668	transmembrane transport
SCO7002	COG0531	amino acid
SCO7004	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SCO7008	COG1132	(ABC) transporter
SCO7010	COG0366	Alpha amylase catalytic
SCO7011	COG0395	ABC-type sugar transport system, permease component
SCO7012	COG1175	transmembrane transport
SCO7013	COG1653	transport
SCO7019	COG1874	Beta-galactosidase
SCO7019	COG0366	Alpha amylase catalytic
SCO7029	COG1175	transmembrane transport
SCO7031	COG1472	Belongs to the glycosyl hydrolase 3 family
SCO7034	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SCO7036	COG0137	argininosuccinate synthase activity
SCO7043	COG0640	Transcriptional regulator
SCO7044	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SCO7045	COG1993	acr, cog1993
SCO7046	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SCO7047	COG1968	undecaprenyl-diphosphatase activity
SCO7049	COG2066	Belongs to the glutaminase family
SCO7050	COG1686	Belongs to the peptidase S11 family
SCO7051	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SCO7054	COG1695	Transcriptional regulator
SCO7055	COG2226	methyltransferase
SCO7056	COG2188	Transcriptional regulator
SCO7057	COG3458	cephalosporin-C deacetylase activity
SCO7060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SCO7062	COG2890	protein-(glutamine-N5) methyltransferase activity
SCO7066	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCO7066	COG1902	pentaerythritol trinitrate reductase activity
SCO7072	COG1461	Dihydroxyacetone kinase
SCO7073	COG2376	Dihydroxyacetone kinase
SCO7075	COG0745	RESPONSE REGULATOR receiver
SCO7076	COG2205	protein histidine kinase activity
SCO7077	COG2409	Drug exporters of the RND superfamily
SCO7081	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SCO7086	COG0789	Transcriptional regulator
SCO7088	COG2197	response regulator
SCO7089	COG4585	Histidine kinase
SCO7090	COG2409	Drug exporters of the RND superfamily
SCO7094	COG1017	nitric oxide dioxygenase activity
SCO7094	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SCO7105	COG1595	DNA-templated transcription, initiation
SCO7109	COG1053	succinate dehydrogenase
SCO7111	COG1764	response to oxidative stress
SCO7112	COG1595	DNA-templated transcription, initiation
SCO7120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SCO7124	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SCO7128	COG0477	Major facilitator Superfamily
SCO7134	COG1672	PFAM Archaeal ATPase
SCO7134	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SCO7137	COG1672	PFAM Archaeal ATPase
SCO7137	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SCO7141	COG0778	Nitroreductase
SCO7144	COG1595	DNA-templated transcription, initiation
SCO7145	COG1846	Transcriptional regulator
SCO7146	COG0640	Transcriptional regulator
SCO7153	COG0477	Major facilitator Superfamily
SCO7154	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SCO7159	COG1289	transmembrane transporter activity
SCO7161	COG1028	Short-chain dehydrogenase reductase Sdr
SCO7163	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SCO7166	COG1175	transmembrane transport
SCO7168	COG2186	Transcriptional regulator
SCO7170	COG3507	Belongs to the glycosyl hydrolase 43 family
SCO7173	COG1672	PFAM Archaeal ATPase
SCO7173	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SCO7176	COG1404	Belongs to the peptidase S8 family
SCO7193	COG2837	iron assimilation
SCO7196	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SCO7197	COG1115	amino acid carrier protein
SCO7205	COG0596	Alpha beta hydrolase
SCO7213	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SCO7215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SCO7216	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCO7217	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SCO7230	COG0745	RESPONSE REGULATOR receiver
SCO7231	COG2205	protein histidine kinase activity
SCO7234	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SCO7236	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SCO7240	COG0515	serine threonine protein kinase
SCO7243	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SCO7244	COG0318	PFAM AMP-dependent synthetase and ligase
SCO7245	COG2267	carboxylic ester hydrolase activity
SCO7254	COG0673	inositol 2-dehydrogenase activity
SCO7264	COG0667	Aldo Keto reductase
SCO7267	COG0346	lactoylglutathione lyase activity
SCO7268	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SCO7270	COG0583	DNA-binding transcription factor activity
SCO7271	COG0667	Aldo Keto reductase
SCO7278	COG1191	sigma factor activity
SCO7279	COG1396	sequence-specific DNA binding
SCO7280	COG0740	serine-type endopeptidase activity
SCO7281	COG0740	serine-type endopeptidase activity
SCO7284	COG0328	RNA-DNA hybrid ribonuclease activity
SCO7286	COG0667	Aldo Keto reductase
SCO7290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SCO7291	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCO7291	COG0515	serine threonine protein kinase
SCO7292	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SCO7294	COG2340	Cysteine-rich secretory protein family
SCO7295	COG2197	response regulator
SCO7301	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCO7309	COG0477	Major facilitator Superfamily
SCO7311	COG1982	Orn Lys Arg decarboxylase major
SCO7319	COG1252	NADH dehydrogenase
SCO7322	COG2172	sigma factor antagonist activity
SCO7323	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO7324	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO7327	COG5002	protein histidine kinase activity
SCO7327	COG2205	protein histidine kinase activity
SCO7327	COG0784	Response regulator, receiver
SCO7331	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SCO7332	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SCO7335	COG0366	Alpha amylase catalytic
SCO7343	COG0181	hydroxymethylbilane synthase activity
SCO7345	COG1793	dna ligase
SCO7345	COG3285	dna ligase
SCO7350	COG2223	nitrite transmembrane transporter activity
SCO7351	COG2207	Transcriptional regulator
SCO7354	COG2208	phosphoserine phosphatase activity
SCO7356	COG0656	L-ascorbic acid biosynthetic process
SCO7360	COG0009	L-threonylcarbamoyladenylate synthase
SCO7370	COG1088	dTDP-glucose 4,6-dehydratase activity
SCO7374	COG0243	molybdopterin cofactor binding
SCO7375	COG0456	acetyltransferase
SCO7384	COG0475	glutathione-regulated potassium exporter activity
SCO7389	COG1028	Short-chain dehydrogenase reductase Sdr
SCO7400	COG1120	ATPase activity
SCO7405	COG0110	maltose O-acetyltransferase activity
SCO7409	COG0395	ABC-type sugar transport system, permease component
SCO7410	COG4209	transmembrane transport
SCO7411	COG1609	Transcriptional regulator
SCO7412	COG0028	Belongs to the TPP enzyme family
SCO7413	COG1028	Short-chain dehydrogenase reductase Sdr
SCO7425	COG2814	Major facilitator Superfamily
SCO7427	COG1959	2 iron, 2 sulfur cluster binding
SCO7432	COG5640	endopeptidase activity
SCO7433	COG0583	DNA-binding transcription factor activity
SCO7435	COG2814	Major facilitator Superfamily
SCO7438	COG0583	DNA-binding transcription factor activity
SCO7439	COG3340	Belongs to the peptidase S51 family
SCO7444	COG2124	cytochrome p450
SCO7455	COG1335	isochorismatase
SCO7459	COG1119	ATPase activity
SCO7461	COG5640	endopeptidase activity
SCO7470	COG2050	protein possibly involved in aromatic compounds catabolism
SCO7471	COG3396	Phenylacetate-CoA oxygenase
SCO7472	COG3460	Phenylacetate-CoA oxygenase
SCO7473	COG3396	Phenylacetate-CoA oxygenase
SCO7474	COG2151	metal-sulfur cluster biosynthetic enzyme
SCO7475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SCO7487	COG0395	ABC-type sugar transport system, permease component
SCO7490	COG1063	alcohol dehydrogenase
SCO7491	COG1082	Xylose isomerase domain protein TIM barrel
SCO7492	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SCO7500	COG1953	Uracil, thiamine, allantoin
SCO7501	COG3940	Belongs to the glycosyl hydrolase 43 family
SCO7502	COG1609	Transcriptional regulator
SCO7504	COG1175	transmembrane transport
SCO7505	COG0395	ABC-type sugar transport system, permease component
SCO7507	COG2175	clavaminate synthase activity
SCO7512	COG4977	sequence-specific DNA binding
SCO7513	COG2755	lipolytic protein G-D-S-L family
SCO7516	COG0326	Molecular chaperone. Has ATPase activity
SCO7517	COG2391	methyltransferase activity
SCO7518	COG3226	Transcriptional regulator
SCO7522	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SCO7523	COG0542	response to heat
SCO7531	COG2755	lipolytic protein G-D-S-L family
SCO7531	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SCO7533	COG0745	RESPONSE REGULATOR receiver
SCO7534	COG2205	protein histidine kinase activity
SCO7536	COG2409	Drug exporters of the RND superfamily
SCO7537	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SCO7540	COG0517	IMP dehydrogenase activity
SCO7540	COG0516	GMP reductase activity
SCO7547	COG3119	arylsulfatase activity
SCO7548	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SCO7550	COG0584	glycerophosphoryl diester phosphodiesterase
SCO7552	COG1309	transcriptional regulator
SCO7557	COG0395	ABC-type sugar transport system, permease component
SCO7561	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SCO7563	COG4533	DNA binding
SCO7564	COG0601	transmembrane transport
SCO7565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCO7566	COG0444	Belongs to the ABC transporter superfamily
SCO7567	COG4608	Belongs to the ABC transporter superfamily
SCO7573	COG1366	Belongs to the anti-sigma-factor antagonist family
SCO7583	COG4733	cellulase activity
SCO7586	COG1902	pentaerythritol trinitrate reductase activity
SCO7594	COG0667	Aldo Keto reductase
SCO7595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SCO7596	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCO7599	COG1737	Transcriptional regulator
SCO7600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SCO7602	COG1309	transcriptional regulator
SCO7607	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SCO7611	COG2045	Belongs to the ComB family
SCO7612	COG2353	YceI-like domain
SCO7622	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SCO7623	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SCO7626	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCO7629	COG4948	Mandelate Racemase Muconate Lactonizing
SCO7630	COG0406	alpha-ribazole phosphatase activity
SCO7632	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SCO7638	COG0148	phosphopyruvate hydratase activity
SCO7640	COG0583	DNA-binding transcription factor activity
SCO7648	COG2197	response regulator
SCO7649	COG4585	Histidine kinase
SCO7650	COG0596	Alpha beta hydrolase
SCO7652	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SCO7654	COG0667	Aldo Keto reductase
SCO7655	COG4989	oxidoreductase activity
SCO7660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SCO7661	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SCO7666	COG0604	alcohol dehydrogenase
SCO7670	COG1755	Isoprenylcysteine carboxyl methyltransferase
SCO7678	COG0601	transmembrane transport
SCO7680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SCO7681	COG1021	2,3-dihydroxybenzoate-AMP ligase
SCO7682	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SCO7682	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SCO7683	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SCO7683	COG2226	methyltransferase
SCO7683	COG3433	isochorismatase activity
SCO7687	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SCO7689	COG1132	(ABC) transporter
SCO7689	COG2375	cellular response to nickel ion
SCO7690	COG1132	(ABC) transporter
SCO7694	COG1309	transcriptional regulator
SCO7697	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
SCO7698	COG0789	Transcriptional regulator
SCO7699	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SCO7700	COG3170	Tfp pilus assembly protein FimV
SCO7701	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SCO7703	COG2807	transmembrane transport
SCO7708	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SCO7709	COG1846	Transcriptional regulator
SCO7711	COG4585	Histidine kinase
SCO7712	COG2197	response regulator
SCO7722	COG2318	DinB family
SCO7726	COG1335	isochorismatase
SCO7740	COG3547	Transposase (IS116 IS110 IS902 family)
SCO7741	COG0431	NADPH-dependent FMN reductase
SCO7746	COG3293	Transposase
SCO7748	COG2770	Histidine kinase
SCO7748	COG2208	phosphoserine phosphatase activity
SCO7760	COG1028	Short-chain dehydrogenase reductase Sdr
SCO7769	COG0702	epimerase
SCO7782	COG3547	Transposase (IS116 IS110 IS902 family)
SCO7803	COG2801	Transposase and inactivated derivatives
SCO7803	COG3415	Transposase
SCO7806	COG2226	methyltransferase
SCO7808	COG3547	Transposase (IS116 IS110 IS902 family)
SCO7809	COG1309	transcriptional regulator
SCO7813	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SCO7814	COG1028	Short-chain dehydrogenase reductase Sdr
SCO7822	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SCO7832	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCP1.148	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCP1.177	COG3046	protein related to deoxyribodipyrimidine photolyase
SCP1.202	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCP1.202	COG0574	Belongs to the PEP-utilizing enzyme family
SCP1.267	COG3345	alpha-galactosidase
SCP1.281	COG1472	Belongs to the glycosyl hydrolase 3 family
SCP1.99	COG3507	Belongs to the glycosyl hydrolase 43 family